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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PAX1_PAX9

Z-value: 0.79

Motif logo

Transcription factors associated with PAX1_PAX9

Gene Symbol	Gene ID	Gene Info
PAX1 Ensembl NCBI GeneCards UniProt	ENSG00000125813.9	PAX1
PAX9 Ensembl NCBI GeneCards UniProt	ENSG00000198807.8	PAX9

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PAX1	chr20_21961725_21961876	274939	0.015233	0.81	8.4e-03	Click!
PAX1	chr20_21698251_21698402	11465	0.305732	-0.78	1.3e-02	Click!
PAX1	chr20_22052219_22052370	365433	0.008806	-0.66	5.4e-02	Click!
PAX1	chr20_21662264_21662415	23958	0.261941	-0.66	5.5e-02	Click!
PAX1	chr20_21683536_21683700	2679	0.416922	-0.56	1.2e-01	Click!
PAX9	chr14_37116502_37116669	10188	0.177446	-0.58	1.0e-01	Click!
PAX9	chr14_37131505_37132074	10	0.976824	-0.56	1.2e-01	Click!
PAX9	chr14_37144898_37145049	13194	0.186371	-0.53	1.4e-01	Click!
PAX9	chr14_37117391_37117614	9271	0.179851	-0.46	2.1e-01	Click!
PAX9	chr14_37125375_37125526	1323	0.404544	-0.42	2.6e-01	Click!

Activity of the PAX1_PAX9 motif across conditions

Conditions sorted by the z-value of the PAX1_PAX9 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_198608305_198608501	0.70	PTPRC	protein tyrosine phosphatase, receptor type, C	111	0.98
chrX_128914480_128914899	0.68	SASH3	SAM and SH3 domain containing 3	729	0.68
chr17_62097753_62097982	0.65	ICAM2	intercellular adhesion molecule 2	44	0.97
chr9_137029602_137029922	0.63	ENSG00000221676	.	76	0.97
chr4_36257318_36257571	0.52	RP11-431M7.3		696	0.72
chr12_102321689_102321840	0.50	RP11-512N21.3		3267	0.22
chr15_86127194_86127729	0.48	RP11-815J21.2		4052	0.21
chr2_99953063_99953235	0.46	TXNDC9	thioredoxin domain containing 9	224	0.81
chr2_207629814_207630047	0.44	MDH1B	malate dehydrogenase 1B, NAD (soluble)	80	0.6
chr2_198160747_198160898	0.44	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	6421	0.18
chr17_79211950_79212101	0.43	ENTHD2	ENTH domain containing 2	627	0.46
chr20_47437784_47438180	0.43	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	6438	0.29
chr6_2999439_2999644	0.41	RP1-90J20.8		173	0.82
chr11_59538510_59538661	0.39	STX3	syntaxin 3	15660	0.13
chr20_52225525_52225734	0.39	ZNF217	zinc finger protein 217	198	0.95
chr19_40791502_40791751	0.39	AKT2	v-akt murine thymoma viral oncogene homolog 2	183	0.89
chr16_2689724_2689875	0.39	PDPK2		2634	0.14
chr21_46529839_46530147	0.38	PRED58		4880	0.17
chr18_74843066_74843217	0.38	MBP	myelin basic protein	499	0.88
chr19_1856293_1856444	0.37	CTB-31O20.8		3881	0.1
chr10_82223089_82223265	0.37	TSPAN14	tetraspanin 14	4119	0.25
chr6_41702064_41702224	0.36	TFEB	transcription factor EB	5	0.96
chr3_25824543_25824893	0.36	OXSM	3-oxoacyl-ACP synthase, mitochondrial	154	0.49
chr10_30723111_30723504	0.35	MAP3K8	mitogen-activated protein kinase kinase kinase 8	134	0.97
chr5_133747742_133748022	0.35	CDKN2AIPNL	CDKN2A interacting protein N-terminal like	293	0.89
chr5_140997567_140997853	0.35	AC008781.7		271	0.75
chr2_64957643_64958616	0.35	ENSG00000253082	.	45109	0.14
chr17_40400915_40401141	0.34	RP11-358B23.5		19577	0.1
chr8_101965285_101965580	0.34	YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta	137	0.95
chr1_1474981_1475180	0.34	TMEM240	transmembrane protein 240	657	0.54
chr7_150066210_150066658	0.34	REPIN1	replication initiator 1	474	0.45
chr3_9885443_9885670	0.33	RPUSD3	RNA pseudouridylate synthase domain containing 3	70	0.94
chr3_15247783_15248155	0.33	CAPN7	calpain 7	219	0.93
chr5_36875665_36875984	0.32	NIPBL	Nipped-B homolog (Drosophila)	1037	0.69
chr9_129183867_129184018	0.31	ENSG00000252985	.	5230	0.22
chr12_58335952_58336152	0.31	XRCC6BP1	XRCC6 binding protein 1	692	0.67
chr6_34856993_34857273	0.31	ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A	53	0.96
chr7_147792201_147792352	0.31	CNTNAP2	contactin associated protein-like 2	38500	0.22
chr20_4794261_4794412	0.30	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	1433	0.44
chr16_30006409_30006560	0.30	INO80E	INO80 complex subunit E	131	0.79
chr18_13612881_13613032	0.29	LDLRAD4	low density lipoprotein receptor class A domain containing 4	338	0.8
chr10_93559450_93559702	0.29	TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	1507	0.34
chr19_6801178_6801329	0.29	VAV1	vav 1 guanine nucleotide exchange factor	17124	0.13
chr19_52132706_52132857	0.29	SIGLEC5	sialic acid binding Ig-like lectin 5	807	0.48
chr14_103852201_103853000	0.29	MARK3	MAP/microtubule affinity-regulating kinase 3	24	0.98
chr5_100236594_100237334	0.29	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	1954	0.48
chr2_69921062_69921213	0.29	ENSG00000238708	.	26646	0.17
chr5_177591147_177591316	0.29	NHP2	NHP2 ribonucleoprotein	10263	0.17
chr16_88770281_88770566	0.28	RNF166	ring finger protein 166	398	0.64
chr6_30585634_30586241	0.27	MRPS18B	mitochondrial ribosomal protein S18B	313	0.67
chr5_154137578_154138162	0.27	LARP1	La ribonucleoprotein domain family, member 1	1136	0.49
chr5_126365438_126366192	0.26	MARCH3	membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase	685	0.77
chr9_4740769_4741101	0.26	AK3	adenylate kinase 3	292	0.91
chr7_50727890_50728167	0.25	GRB10	growth factor receptor-bound protein 10	33401	0.21
chr1_6684874_6685147	0.25	THAP3	THAP domain containing, apoptosis associated protein 3	84	0.95
chr18_22744503_22745506	0.25	ZNF521	zinc finger protein 521	59749	0.16
chr12_132413289_132413563	0.25	PUS1	pseudouridylate synthase 1	319	0.87
chr4_77996688_77997050	0.25	CCNI	cyclin I	273	0.93
chr7_3083802_3083953	0.25	CARD11	caspase recruitment domain family, member 11	298	0.93
chr9_90113946_90114123	0.24	DAPK1	death-associated protein kinase 1	114	0.98
chr17_39968419_39968821	0.24	LEPREL4	leprecan-like 4	169	0.65
chr2_74766675_74766942	0.24	DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	9345	0.07
chr13_67106963_67107114	0.24	ENSG00000238500	.	97870	0.09
chr6_37140750_37140901	0.24	PIM1	pim-1 oncogene	2846	0.25
chr22_24408267_24408637	0.24	CABIN1	calcineurin binding protein 1	584	0.65
chr8_26435531_26436419	0.23	DPYSL2	dihydropyrimidinase-like 2	54	0.98
chr21_36901341_36902041	0.23	ENSG00000211590	.	191322	0.03
chr22_39745597_39745764	0.23	SYNGR1	synaptogyrin 1	250	0.88
chr5_72251895_72252188	0.23	FCHO2	FCH domain only 2	143	0.97
chr18_33077197_33077498	0.23	INO80C	INO80 complex subunit C	216	0.79
chr11_67251391_67251565	0.23	AIP	aryl hydrocarbon receptor interacting protein	966	0.31
chrX_79830027_79830462	0.23	FAM46D	family with sequence similarity 46, member D	154279	0.04
chr13_110055389_110055540	0.22	MYO16-AS1	MYO16 antisense RNA 1	201633	0.03
chr14_23388119_23388349	0.22	RBM23	RNA binding motif protein 23	104	0.8
chr19_47989811_47989962	0.22	NAPA-AS1	NAPA antisense RNA 1	2321	0.19
chr17_14206700_14206851	0.22	HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	2375	0.39
chr2_54823751_54824124	0.22	SPTBN1	spectrin, beta, non-erythrocytic 1	38406	0.14
chr6_108581372_108582140	0.22	SNX3	sorting nexin 3	412	0.8
chr13_111364022_111364765	0.22	ING1	inhibitor of growth family, member 1	690	0.72
chr10_27389546_27389885	0.21	ANKRD26	ankyrin repeat domain 26	294	0.9
chr1_207496793_207497173	0.21	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	1847	0.46
chr19_52149205_52149440	0.21	SIGLEC5	sialic acid binding Ig-like lectin 5	524	0.49
chr6_26341940_26342091	0.21	ENSG00000252399	.	11249	0.09
chr6_6588687_6588838	0.21	LY86	lymphocyte antigen 86	140	0.95
chr16_3074363_3074588	0.21	HCFC1R1	host cell factor C1 regulator 1 (XPO1 dependent)	188	0.65
chr1_202776022_202776519	0.21	KDM5B	lysine (K)-specific demethylase 5B	157	0.93
chr7_93753483_93753634	0.21	BET1	Bet1 golgi vesicular membrane trafficking protein	119864	0.06
chr3_18486507_18486658	0.21	ENSG00000228956	.	66	0.7
chr14_62035309_62035460	0.21	RP11-47I22.3	Uncharacterized protein	1930	0.36
chr9_127025877_127026028	0.20	RP11-121A14.3		797	0.55
chr11_128422978_128423129	0.20	RP11-1007G5.2		27016	0.2
chr10_76345165_76345892	0.20	ENSG00000206756	.	34378	0.2
chr8_121824505_121824719	0.20	RP11-713M15.2		153	0.61
chr17_33814121_33814953	0.19	SLFN12L	schlafen family member 12-like	316	0.84
chr9_468840_468991	0.19	RP11-165F24.3		887	0.45
chr2_44222356_44222725	0.19	LRPPRC	leucine-rich pentatricopeptide repeat containing	575	0.82
chr2_68383846_68384031	0.19	WDR92	WD repeat domain 92	667	0.53
chr14_22447214_22447365	0.19	ENSG00000238634	.	163598	0.03
chr14_53618338_53618850	0.19	DDHD1	DDHD domain containing 1	1222	0.3
chr10_134364208_134364359	0.19	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	12640	0.21
chr12_120700998_120701172	0.18	PXN	paxillin	2478	0.18
chr20_62257208_62257699	0.18	GMEB2	glucocorticoid modulatory element binding protein 2	941	0.32
chr2_240187102_240187645	0.18	ENSG00000265215	.	39784	0.13
chr9_93573094_93573245	0.18	SYK	spleen tyrosine kinase	8960	0.33
chr2_98334930_98335281	0.17	ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	5082	0.19
chr16_58034790_58035185	0.17	USB1	U6 snRNA biogenesis 1	290	0.71
chr9_115571889_115572040	0.17	SNX30	sorting nexin family member 30	28901	0.18
chr15_73587715_73587866	0.17	RP11-272D12.2		39340	0.16
chr17_75452866_75453125	0.17	SEPT9	septin 9	547	0.72
chr2_26726429_26726904	0.17	OTOF	otoferlin	25756	0.17
chr19_37177817_37178305	0.17	ZNF567	zinc finger protein 567	469	0.78
chrX_154032790_154032975	0.17	MPP1	membrane protein, palmitoylated 1, 55kDa	790	0.52
chr7_7679826_7680046	0.17	RPA3	replication protein A3, 14kDa	279	0.94
chr5_179246588_179246964	0.17	SQSTM1	sequestosome 1	898	0.41
chr11_747907_748726	0.17	TALDO1	transaldolase 1	888	0.33
chr3_29185407_29185558	0.17	ENSG00000238470	.	132749	0.05
chr1_192777377_192777993	0.16	RGS2	regulator of G-protein signaling 2, 24kDa	486	0.87
chr2_86669408_86669754	0.16	KDM3A	lysine (K)-specific demethylase 3A	410	0.86
chr7_18461225_18461376	0.16	AC010082.2		9061	0.28
chr5_142600508_142600686	0.16	ARHGAP26	Rho GTPase activating protein 26	13832	0.24
chrX_73512588_73513347	0.16	ENSG00000199168	.	5775	0.15
chr15_76630019_76630254	0.16	ISL2	ISL LIM homeobox 2	1071	0.52
chr4_100742826_100743086	0.16	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	4953	0.27
chr15_41316618_41316840	0.16	RP11-540O11.4		32	0.97
chr19_1088228_1088379	0.16	POLR2E	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	7050	0.1
chr5_149792089_149792429	0.16	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	36	0.97
chr7_5230948_5231124	0.16	WIPI2	WD repeat domain, phosphoinositide interacting 2	1132	0.48
chr20_61549533_61549684	0.16	DIDO1	death inducer-obliterator 1	3850	0.18
chr10_105727511_105727782	0.16	SLK	STE20-like kinase	687	0.66
chrX_55186864_55187302	0.15	FAM104B	family with sequence similarity 104, member B	452	0.82
chr8_21817389_21817540	0.15	XPO7	exportin 7	6285	0.19
chr1_26758963_26759170	0.15	DHDDS	dehydrodolichyl diphosphate synthase	172	0.93
chr12_54753390_54753672	0.15	GPR84	G protein-coupled receptor 84	4727	0.09
chr2_109237700_109238010	0.15	LIMS1	LIM and senescent cell antigen-like domains 1	133	0.97
chr16_53983720_53983924	0.15	FTO	fat mass and obesity associated	15880	0.2
chr6_33393517_33393718	0.15	SYNGAP1	synaptic Ras GTPase activating protein 1	5585	0.11
chr2_86850787_86850979	0.15	RNF103	ring finger protein 103	95	0.91
chr12_107350126_107350477	0.15	C12orf23	chromosome 12 open reading frame 23	262	0.85
chr13_99911468_99911619	0.14	GPR18	G protein-coupled receptor 18	861	0.62
chr6_15268791_15268942	0.14	JARID2	jumonji, AT rich interactive domain 2	19723	0.17
chr5_79647576_79647767	0.14	ENSG00000206774	.	13980	0.17
chr17_77817111_77817406	0.14	CBX4	chromobox homolog 4	4030	0.19
chr11_27695896_27696047	0.14	BDNF-AS	BDNF antisense RNA	9164	0.23
chr9_115096689_115097200	0.14	PTBP3	polypyrimidine tract binding protein 3	997	0.57
chr17_77071312_77071553	0.14	ENGASE	endo-beta-N-acetylglucosaminidase	281	0.89
chr4_3533160_3533351	0.14	LRPAP1	low density lipoprotein receptor-related protein associated protein 1	1031	0.5
chr2_232062733_232062927	0.14	ARMC9	armadillo repeat containing 9	430	0.86
chr15_40475830_40476133	0.14	BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B	22713	0.12
chr8_142275255_142276084	0.14	RP11-10J21.3	Uncharacterized protein	11005	0.14
chr14_64319967_64320824	0.13	SYNE2	spectrin repeat containing, nuclear envelope 2	663	0.73
chr20_4707737_4707988	0.13	PRND	prion protein 2 (dublet)	5306	0.21
chr5_148725091_148725557	0.13	GRPEL2	GrpE-like 2, mitochondrial (E. coli)	259	0.87
chr17_81040457_81040608	0.13	METRNL	meteorin, glial cell differentiation regulator-like	1417	0.48
chr17_56410108_56410593	0.13	MIR142	microRNA 142	481	0.66
chr2_26569037_26569246	0.13	EPT1	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	124	0.84
chr21_46973241_46973392	0.13	SLC19A1	solute carrier family 19 (folate transporter), member 1	8991	0.23
chr1_22109491_22109642	0.13	USP48	ubiquitin specific peptidase 48	82	0.97
chr5_177632434_177632741	0.13	HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	1015	0.54
chr6_10412096_10412574	0.13	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	272	0.9
chr13_51795997_51796228	0.13	FAM124A	family with sequence similarity 124A	391	0.9
chr8_121822100_121822251	0.12	SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	2208	0.3
chr1_235323819_235324540	0.12	RBM34	RNA binding motif protein 34	356	0.84
chr12_78002829_78002980	0.12	AC073528.1		52336	0.19
chr17_27229464_27229953	0.12	DHRS13	dehydrogenase/reductase (SDR family) member 13	275	0.78
chr19_56826578_56826877	0.12	AC006116.17		104	0.79
chr3_150995573_150995821	0.12	P2RY14	purinergic receptor P2Y, G-protein coupled, 14	460	0.8
chr13_21140562_21140933	0.12	IFT88	intraflagellar transport 88 homolog (Chlamydomonas)	162	0.96
chr11_67186305_67186456	0.11	PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	2272	0.11
chr19_8478353_8478504	0.11	MARCH2	membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase	122	0.93
chr16_90172947_90173188	0.11	PRDM7	PR domain containing 7	30729	0.13
chr19_41222549_41222955	0.11	ADCK4	aarF domain containing kinase 4	38	0.76
chr15_90437690_90437846	0.11	AP3S2	adaptor-related protein complex 3, sigma 2 subunit	194	0.88
chr11_126138529_126138703	0.11	SRPR	signal recognition particle receptor (docking protein)	238	0.63
chr6_144461776_144461927	0.11	STX11	syntaxin 11	9812	0.24
chr1_161903850_161904001	0.11	OLFML2B	olfactomedin-like 2B	51097	0.14
chr6_113650155_113650306	0.11	ENSG00000222677	.	185959	0.03
chr15_49102623_49102987	0.11	CEP152	centrosomal protein 152kDa	14	0.57
chr9_93644008_93644159	0.11	SYK	spleen tyrosine kinase	54313	0.18
chr19_344917_345170	0.11	MIER2	mesoderm induction early response 1, family member 2	250	0.9
chr8_28972672_28972823	0.11	CTD-2647L4.1		4657	0.17
chr7_151038891_151039078	0.10	NUB1	negative regulator of ubiquitin-like proteins 1	86	0.96
chr16_2318513_2318889	0.10	RNPS1	RNA binding protein S1, serine-rich domain	288	0.64
chr6_21595977_21596233	0.10	SOX4	SRY (sex determining region Y)-box 4	2034	0.5
chr12_90693182_90693369	0.10	ENSG00000252823	.	545439	0.0
chr14_23387653_23388059	0.10	RBM23	RNA binding motif protein 23	482	0.48
chr11_47421524_47421704	0.10	ENSG00000264583	.	907	0.36
chr15_20980933_20981246	0.10	AC012414.1	Uncharacterized protein	23598	0.15
chr3_71111322_71111570	0.10	FOXP1	forkhead box P1	2631	0.43
chr21_46239564_46239715	0.10	SUMO3	small ubiquitin-like modifier 3	1595	0.28
chr16_68279313_68279519	0.10	PLA2G15	phospholipase A2, group XV	121	0.9
chrX_109247622_109247773	0.10	TMEM164	transmembrane protein 164	1354	0.53
chr15_34627235_34627720	0.09	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	1568	0.25
chr6_35268137_35268288	0.09	DEF6	differentially expressed in FDCP 6 homolog (mouse)	2583	0.26
chr13_98086771_98087714	0.09	RAP2A	RAP2A, member of RAS oncogene family	766	0.75
chr14_99697762_99697913	0.09	AL109767.1		31448	0.18
chr2_46925496_46926304	0.09	SOCS5	suppressor of cytokine signaling 5	191	0.95
chr14_60716792_60717657	0.09	PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A	75	0.97
chr8_56806111_56806262	0.09	RP11-318K15.2		32	0.97
chr10_99258721_99258937	0.09	UBTD1	ubiquitin domain containing 1	204	0.61
chr14_105885619_105886050	0.09	RP11-521B24.3		242	0.57

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.3	GO:0001821	histamine secretion(GO:0001821)
0.1	0.5	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.1	0.3	GO:2000192	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.1	0.2	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.1	0.2	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1	0.2	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.1	0.2	GO:0034088	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.1	0.1	GO:0002328	pro-B cell differentiation(GO:0002328)
0.1	0.2	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.2	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.2	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0045625	regulation of T-helper 1 cell differentiation(GO:0045625)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.6	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	0.1	GO:0032212	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.2	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.3	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.2	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.2	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.3	GO:0045577	regulation of B cell differentiation(GO:0045577)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.2	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.2	GO:0034643	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.1	GO:0005997	xylulose metabolic process(GO:0005997)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0070933	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.1	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.2	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0045047	protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0046184	aldehyde biosynthetic process(GO:0046184)
0.0	0.1	GO:0010915	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0090022	regulation of neutrophil chemotaxis(GO:0090022) regulation of neutrophil migration(GO:1902622)
0.0	0.1	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.3	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.0	0.0	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0032593	insulin-responsive compartment(GO:0032593)
0.1	0.6	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1	0.3	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.4	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.2	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.2	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.5	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.1	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.2	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.2	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.2	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.1	0.2	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.7	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.3	GO:0016615	malate dehydrogenase activity(GO:0016615)
0.0	0.5	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.2	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.2	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.2	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.2	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0016744	transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.0	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.0	GO:0008518	reduced folate carrier activity(GO:0008518)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.3	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.7	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.3	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.2	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.2	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.1	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE