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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for PBX1

Z-value: 0.88

Motif logo

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Transcription factors associated with PBX1

Gene Symbol Gene ID Gene Info
PBX1
ENSG00000185630.14 PBX homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr1_164532740_164533333PBX19940.6680700.901.0e-03Click!
chr1_164545287_164545502PBX1133520.2536670.845.1e-03Click!
chr1_164532131_164532342PBX11940.9655610.751.9e-02Click!
chr1_164530790_164530941PBX111770.6093210.752.0e-02Click!
chr1_164545611_164545762PBX1136440.2526920.732.6e-02Click!

Activity of the PBX1 motif across conditions

Conditions sorted by the z-value of the PBX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr5_54456456_54456818 0.39 GPX8
 glutathione peroxidase 8 (putative)
 639
 0.58
chrX_34673939_34674563 0.37 TMEM47
 transmembrane protein 47
 1154
 0.68
chr12_85305887_85306488 0.36 SLC6A15
 solute carrier family 6 (neutral amino acid transporter), member 15
 384
 0.92
chr7_28429293_28429606 0.35 CREB5
 cAMP responsive element binding protein 5
 19557
 0.28
chr9_134875172_134875430 0.35 MED27
 mediator complex subunit 27
 79952
 0.1
chr10_33620428_33620906 0.33 NRP1
 neuropilin 1
 2643
 0.37
chr2_3625481_3625934 0.33 ENSG00000252531
 .
 2453
 0.16
chr5_102202832_102203172 0.32 PAM
 peptidylglycine alpha-amidating monooxygenase
 1182
 0.66
chr7_46330968_46331124 0.32 ENSG00000239004
 .
 316009
 0.01
chr6_121756849_121757212 0.32 GJA1
 gap junction protein, alpha 1, 43kDa
 192
 0.94
chr8_19148668_19149118 0.31 SH2D4A
 SH2 domain containing 4A
 22235
 0.28
chr10_73725086_73725706 0.31 CHST3
 carbohydrate (chondroitin 6) sulfotransferase 3
 1273
 0.55
chr6_73263483_73264009 0.30 KCNQ5
 potassium voltage-gated channel, KQT-like subfamily, member 5
 67774
 0.12
chr11_12699031_12699547 0.30 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
 2239
 0.43
chr8_126557595_126557859 0.30 ENSG00000266452
 .
 100920
 0.08
chr14_55144332_55144669 0.29 SAMD4A
 sterile alpha motif domain containing 4A
 77051
 0.1
chr9_18474095_18474958 0.29 ADAMTSL1
 ADAMTS-like 1
 295
 0.95
chr18_53214040_53214242 0.29 TCF4
 transcription factor 4
 36141
 0.18
chr6_165722551_165723097 0.28 C6orf118
 chromosome 6 open reading frame 118
 272
 0.95
chr7_111002999_111003219 0.28 IMMP2L
 IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
 29862
 0.26
chr4_114899439_114899761 0.27 ARSJ
 arylsulfatase family, member J
 552
 0.84
chr2_74968036_74968578 0.27 SEMA4F
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
 86869
 0.07
chr15_35598532_35598857 0.27 ENSG00000265102
 .
 65871
 0.14
chr1_164532740_164533333 0.26 PBX1
 pre-B-cell leukemia homeobox 1
 994
 0.67
chr1_235904828_235905136 0.26 LYST
 lysosomal trafficking regulator
 10489
 0.24
chr4_183066487_183066672 0.26 AC108142.1
177
 0.77
chr2_190044545_190044696 0.26 COL5A2
 collagen, type V, alpha 2
 15
 0.98
chr3_87039220_87039752 0.24 VGLL3
 vestigial like 3 (Drosophila)
 366
 0.93
chr11_122072235_122072431 0.24 ENSG00000207994
 .
 49317
 0.12
chr4_177931083_177931234 0.24 ENSG00000222859
 .
 171438
 0.03
chr21_28215601_28215791 0.24 ADAMTS1
 ADAM metallopeptidase with thrombospondin type 1 motif, 1
 163
 0.97
chr5_42423266_42423460 0.24 GHR
 growth hormone receptor
 516
 0.88
chr4_30726767_30727321 0.24 PCDH7
 protocadherin 7
 3067
 0.38
chr1_51726454_51726959 0.24 RP11-296A18.6
5040
 0.16
chr7_78398482_78399243 0.24 MAGI2
 membrane associated guanylate kinase, WW and PDZ domain containing 2
 1534
 0.56
chr6_139116835_139117557 0.23 ECT2L
 epithelial cell transforming sequence 2 oncogene-like
 61
 0.98
chr5_174162455_174162926 0.23 MSX2
 msh homeobox 2
 11085
 0.25
chr13_38444595_38444746 0.23 TRPC4
 transient receptor potential cation channel, subfamily C, member 4
 108
 0.98
chr12_88971091_88971358 0.23 KITLG
 KIT ligand
 3014
 0.3
chr3_153840530_153840806 0.23 ARHGEF26
 Rho guanine nucleotide exchange factor (GEF) 26
 1439
 0.37
chr11_125929052_125929203 0.23 CDON
 cell adhesion associated, oncogene regulated
 3579
 0.26
chr12_14537227_14537378 0.23 ATF7IP
 activating transcription factor 7 interacting protein
 696
 0.76
chr10_33299780_33299931 0.23 ITGB1
 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
 5135
 0.26
chr7_54731814_54732170 0.23 ENSG00000200471
 .
 43274
 0.17
chr4_177192718_177192869 0.23 ASB5
 ankyrin repeat and SOCS box containing 5
 2420
 0.32
chrX_11456470_11456766 0.22 ARHGAP6
 Rho GTPase activating protein 6
 10725
 0.3
chr6_169652381_169652976 0.22 THBS2
 thrombospondin 2
 432
 0.89
chr20_14314803_14314963 0.22 FLRT3
 fibronectin leucine rich transmembrane protein 3
 3371
 0.3
chr13_38172711_38172913 0.22 POSTN
 periostin, osteoblast specific factor
 51
 0.99
chr15_72529055_72529849 0.22 PKM
 pyruvate kinase, muscle
 5288
 0.17
chrX_33228916_33229133 0.22 DMD
 dystrophin
 405
 0.92
chr2_221969079_221969387 0.22 EPHA4
 EPH receptor A4
 398047
 0.01
chr1_147148877_147149210 0.22 ACP6
 acid phosphatase 6, lysophosphatidic
 6425
 0.22
chr8_37556496_37556710 0.22 ZNF703
 zinc finger protein 703
 3334
 0.17
chr3_55513844_55514078 0.22 WNT5A
 wingless-type MMTV integration site family, member 5A
 1263
 0.55
chr11_35512807_35513203 0.22 PAMR1
 peptidase domain containing associated with muscle regeneration 1
 34146
 0.18
chr5_17021245_17021396 0.21 BASP1
 brain abundant, membrane attached signal protein 1
 44387
 0.15
chr12_31480010_31480161 0.21 FAM60A
 family with sequence similarity 60, member A
 93
 0.96
chr8_119016675_119016955 0.21 EXT1
 exostosin glycosyltransferase 1
 105838
 0.08
chr1_100112033_100112261 0.21 PALMD
 palmdelphin
 398
 0.9
chr1_95009725_95009876 0.21 F3
 coagulation factor III (thromboplastin, tissue factor)
 2444
 0.41
chr4_187646262_187646501 0.21 FAT1
 FAT atypical cadherin 1
 1372
 0.58
chr3_86992006_86992157 0.21 VGLL3
 vestigial like 3 (Drosophila)
 47771
 0.2
chr1_95388573_95389173 0.21 CNN3
 calponin 3, acidic
 2464
 0.27
chr3_29735259_29735935 0.21 RBMS3-AS2
 RBMS3 antisense RNA 2
 51297
 0.19
chr8_106743100_106743756 0.21 RP11-642D21.2
45435
 0.16
chr12_54089934_54090280 0.21 CALCOCO1
 calcium binding and coiled-coil domain 1
 18306
 0.14
chr3_55514769_55515136 0.21 WNT5A
 wingless-type MMTV integration site family, member 5A
 272
 0.94
chr7_112626035_112626431 0.21 C7orf60
 chromosome 7 open reading frame 60
 46262
 0.17
chr7_80377911_80378104 0.21 CD36
 CD36 molecule (thrombospondin receptor)
 75315
 0.12
chr3_116163075_116163431 0.21 LSAMP
 limbic system-associated membrane protein
 577
 0.84
chr1_19947101_19947252 0.21 NBL1
 neuroblastoma 1, DAN family BMP antagonist
 19872
 0.12
chr7_80546807_80546971 0.21 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 1610
 0.56
chr10_89307360_89307659 0.21 ENSG00000222192
 .
 15434
 0.21
chr8_89337580_89337731 0.21 RP11-586K2.1
1410
 0.42
chrX_28605228_28605520 0.21 IL1RAPL1
 interleukin 1 receptor accessory protein-like 1
 142
 0.98
chr16_80840676_80840857 0.20 CDYL2
 chromodomain protein, Y-like 2
 2540
 0.35
chr8_38205354_38205751 0.20 RP11-513D5.2
12053
 0.13
chr3_87383057_87383208 0.20 POU1F1
 POU class 1 homeobox 1
 57395
 0.15
chr20_17553764_17553929 0.20 DSTN
 destrin (actin depolymerizing factor)
 3119
 0.21
chr10_36184684_36184984 0.20 FZD8
 frizzled family receptor 8
 254472
 0.02
chr2_64876893_64877273 0.20 SERTAD2
 SERTA domain containing 2
 3964
 0.28
chr12_88972313_88972545 0.20 KITLG
 KIT ligand
 1809
 0.39
chr16_2177423_2177723 0.20 ENSG00000200059
 .
 4279
 0.06
chr2_235933296_235933447 0.20 SH3BP4
 SH3-domain binding protein 4
 29887
 0.26
chr6_169653692_169653887 0.20 THBS2
 thrombospondin 2
 350
 0.92
chr18_25751825_25751976 0.20 CDH2
 cadherin 2, type 1, N-cadherin (neuronal)
 5510
 0.36
chr3_120168336_120168615 0.20 FSTL1
 follistatin-like 1
 1363
 0.54
chr9_112813940_112814168 0.20 AKAP2
 A kinase (PRKA) anchor protein 2
 3078
 0.38
chr9_93058938_93059089 0.20 ENSG00000263967
 .
 273196
 0.02
chr10_65473071_65473288 0.20 REEP3
 receptor accessory protein 3
 192056
 0.03
chr22_40894900_40895196 0.20 RP4-591N18.2
22756
 0.15
chr22_39711605_39711921 0.19 ENSG00000209482
 .
 451
 0.66
chr17_69629060_69629258 0.19 ENSG00000222563
 .
 321850
 0.01
chr1_95390838_95390989 0.19 CNN3
 calponin 3, acidic
 424
 0.81
chr6_28641788_28642196 0.19 ENSG00000272278
 .
 25950
 0.18
chr13_40176110_40176261 0.19 LHFP
 lipoma HMGIC fusion partner
 1123
 0.55
chr18_57362819_57362970 0.19 RP11-2N1.2
797
 0.55
chr12_54391177_54391923 0.19 HOXC-AS2
 HOXC cluster antisense RNA 2
 981
 0.22
chr7_116167584_116167883 0.19 CAV1
 caveolin 1, caveolae protein, 22kDa
 1386
 0.37
chr2_111206913_111207281 0.19 RP13-1039J1.3
278
 0.91
chr11_27722222_27723091 0.19 BDNF
 brain-derived neurotrophic factor
 56
 0.98
chr7_134465998_134466492 0.19 CALD1
 caldesmon 1
 1816
 0.49
chr18_48571368_48571694 0.19 SMAD4
 SMAD family member 4
 202
 0.96
chr5_145318270_145318548 0.19 SH3RF2
 SH3 domain containing ring finger 2
 969
 0.66
chr11_101991103_101991395 0.19 YAP1
 Yes-associated protein 1
 8004
 0.18
chr21_35899555_35899706 0.19 RCAN1
 regulator of calcineurin 1
 369
 0.87
chr10_8201743_8201894 0.19 GATA3
 GATA binding protein 3
 105049
 0.08
chr10_8635845_8635996 0.19 ENSG00000212505
 .
 62874
 0.16
chr2_151339584_151339865 0.19 RND3
 Rho family GTPase 3
 2172
 0.49
chr6_3156631_3156782 0.19 TUBB2A
 tubulin, beta 2A class IIa
 1054
 0.43
chr19_20149056_20149207 0.19 ZNF682
 zinc finger protein 682
 883
 0.56
chr14_23447971_23448151 0.19 AJUBA
 ajuba LIM protein
 1115
 0.25
chr6_44424385_44424803 0.19 ENSG00000266619
 .
 21216
 0.17
chrX_45482024_45482567 0.19 ENSG00000207870
 .
 123399
 0.06
chr12_77457624_77458072 0.19 E2F7
 E2F transcription factor 7
 1482
 0.56
chr3_149298860_149299373 0.18 WWTR1
 WW domain containing transcription regulator 1
 5077
 0.23
chr1_20810069_20810220 0.18 CAMK2N1
 calcium/calmodulin-dependent protein kinase II inhibitor 1
 2569
 0.29
chr15_75942874_75943101 0.18 SNX33
 sorting nexin 33
 890
 0.37
chr15_40339032_40339183 0.18 SRP14
 signal recognition particle 14kDa (homologous Alu RNA binding protein)
 7718
 0.16
chr1_27425556_27426394 0.18 SLC9A1
 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
 54998
 0.1
chr8_42063953_42065062 0.18 PLAT
 plasminogen activator, tissue
 576
 0.71
chr11_121968787_121969071 0.18 ENSG00000207971
 .
 1623
 0.3
chr13_98826337_98826632 0.18 RNF113B
 ring finger protein 113B
 3035
 0.21
chr1_85064609_85064886 0.18 CTBS
 chitobiase, di-N-acetyl-
 24600
 0.17
chr11_27739578_27739815 0.18 BDNF
 brain-derived neurotrophic factor
 1598
 0.49
chr6_79314382_79314680 0.18 IRAK1BP1
 interleukin-1 receptor-associated kinase 1 binding protein 1
 262658
 0.02
chr1_209577581_209577868 0.18 ENSG00000230937
 .
 27754
 0.24
chr1_103571993_103572213 0.18 COL11A1
 collagen, type XI, alpha 1
 1631
 0.56
chr1_172110530_172111247 0.18 ENSG00000207949
 .
 2841
 0.22
chr8_141436376_141436676 0.18 TRAPPC9
 trafficking protein particle complex 9
 24503
 0.23
chr9_134554105_134554369 0.18 RAPGEF1
 Rap guanine nucleotide exchange factor (GEF) 1
 30992
 0.18
chr20_14317720_14318261 0.18 FLRT3
 fibronectin leucine rich transmembrane protein 3
 264
 0.94
chr4_74316638_74316988 0.18 AFP
 alpha-fetoprotein
 14849
 0.2
chr7_17411558_17411747 0.18 ENSG00000199473
 .
 1298
 0.57
chr12_90485372_90485572 0.18 ENSG00000252823
 .
 337636
 0.01
chr11_122037044_122037237 0.18 ENSG00000207994
 .
 14124
 0.17
chr17_16286606_16286915 0.18 RP11-138I1.4
777
 0.51
chr9_22683479_22683652 0.18 DMRTA1
 DMRT-like family A1
 236725
 0.02
chr14_35629027_35629224 0.18 KIAA0391
 KIAA0391
 37160
 0.15
chr11_6340007_6340271 0.18 PRKCDBP
 protein kinase C, delta binding protein
 1623
 0.33
chr5_35130063_35130359 0.17 PRLR
 prolactin receptor
 235
 0.95
chr18_18697894_18698383 0.17 ENSG00000251886
 .
 2329
 0.32
chr12_100628376_100628664 0.17 ENSG00000206790
 .
 23048
 0.11
chr2_224477610_224477904 0.17 SCG2
 secretogranin II
 10536
 0.31
chr4_177712658_177713139 0.17 VEGFC
 vascular endothelial growth factor C
 983
 0.71
chr16_65152808_65153250 0.17 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 2804
 0.44
chr3_159847220_159847374 0.17 IL12A-AS1
 IL12A antisense RNA 1
 77582
 0.09
chr8_20126437_20126669 0.17 LZTS1
 leucine zipper, putative tumor suppressor 1
 13750
 0.19
chr1_64096235_64096386 0.17 PGM1
 phosphoglucomutase 1
 7546
 0.2
chr3_171814831_171814982 0.17 FNDC3B
 fibronectin type III domain containing 3B
 29858
 0.23
chr4_110910630_110910781 0.17 ENSG00000207260
 .
 2776
 0.34
chr15_96878987_96879612 0.17 ENSG00000222651
 .
 2809
 0.21
chr4_144303651_144303881 0.17 GAB1
 GRB2-associated binding protein 1
 668
 0.76
chr22_46462951_46463814 0.17 RP6-109B7.4
2389
 0.16
chr6_52532294_52532590 0.17 RP1-152L7.5
2370
 0.29
chr2_30888986_30889287 0.17 CAPN13
 calpain 13
 141175
 0.05
chr3_99593001_99593152 0.17 FILIP1L
 filamin A interacting protein 1-like
 1872
 0.43
chr12_119617594_119617745 0.17 HSPB8
 heat shock 22kDa protein 8
 274
 0.89
chr8_89338361_89338512 0.17 RP11-586K2.1
629
 0.66
chr12_13025379_13025989 0.17 GPRC5A
 G protein-coupled receptor, family C, group 5, member A
 18032
 0.14
chr8_119120675_119121215 0.17 EXT1
 exostosin glycosyltransferase 1
 1708
 0.54
chrX_16840604_16840755 0.17 RBBP7
 retinoblastoma binding protein 7
 29509
 0.14
chr1_32168571_32169014 0.17 COL16A1
 collagen, type XVI, alpha 1
 976
 0.48
chr7_41737032_41737183 0.17 INHBA
 inhibin, beta A
 3100
 0.25
chr14_53416235_53416562 0.17 FERMT2
 fermitin family member 2
 888
 0.69
chr13_100635534_100635685 0.17 ZIC2
 Zic family member 2
 1583
 0.38
chr5_9047596_9047771 0.17 ENSG00000266415
 .
 6324
 0.29
chr11_93865075_93865400 0.17 PANX1
 pannexin 1
 3142
 0.34
chr3_61549164_61549336 0.17 PTPRG
 protein tyrosine phosphatase, receptor type, G
 1665
 0.55
chr17_36623721_36623872 0.17 ARHGAP23
 Rho GTPase activating protein 23
 4384
 0.19
chr13_50650853_50651004 0.17 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
 5379
 0.18
chr1_87244034_87244185 0.17 SH3GLB1
 SH3-domain GRB2-like endophilin B1
 73531
 0.09
chr18_74798828_74799607 0.17 MBP
 myelin basic protein
 18000
 0.27
chr15_81614829_81615120 0.16 STARD5
 StAR-related lipid transfer (START) domain containing 5
 1492
 0.33
chr19_54538995_54539193 0.16 VSTM1
 V-set and transmembrane domain containing 1
 22583
 0.08
chr12_78334342_78334902 0.16 NAV3
 neuron navigator 3
 25434
 0.27
chr3_156409477_156409860 0.16 TIPARP
 TCDD-inducible poly(ADP-ribose) polymerase
 10713
 0.23
chr10_61385710_61385861 0.16 SLC16A9
 solute carrier family 16, member 9
 84052
 0.11
chr6_121757423_121758012 0.16 GJA1
 gap junction protein, alpha 1, 43kDa
 879
 0.59
chr21_43085116_43085274 0.16 LINC00112
 long intergenic non-protein coding RNA 112
 51401
 0.12
chr22_37828954_37829105 0.16 ELFN2
 extracellular leucine-rich repeat and fibronectin type III domain containing 2
 5524
 0.16
chr1_183132842_183132993 0.16 LAMC2
 laminin, gamma 2
 22456
 0.18
chr14_50453745_50453978 0.16 C14orf182
 chromosome 14 open reading frame 182
 20377
 0.16
chr3_65941462_65941807 0.16 MAGI1-IT1
 MAGI1 intronic transcript 1 (non-protein coding)
 1401
 0.43
chr19_18655304_18655455 0.16 FKBP8
 FK506 binding protein 8, 38kDa
 492
 0.6
chr22_31033608_31033759 0.16 SLC35E4
 solute carrier family 35, member E4
 1173
 0.36
chr1_154597059_154597346 0.16 ADAR
 adenosine deaminase, RNA-specific
 3238
 0.19
chr22_46480425_46480827 0.16 FLJ27365
 hsa-mir-4763
 1257
 0.28
chr4_184880881_184881125 0.16 STOX2
 storkhead box 2
 409
 0.89
chr20_30292538_30292716 0.16 AL160175.1
16374
 0.12
chr7_137402579_137403024 0.16 DGKI
 diacylglycerol kinase, iota
 128481
 0.05
chr3_98619314_98619465 0.16 DCBLD2
 discoidin, CUB and LCCL domain containing 2
 626
 0.66
chr17_750320_750517 0.16 NXN
 nucleoredoxin
 16919
 0.14
chr7_27142394_27142575 0.16 HOXA2
 homeobox A2
 54
 0.93
chrX_114467670_114468385 0.16 LRCH2
 leucine-rich repeats and calponin homology (CH) domain containing 2
 601
 0.77
chr9_128728923_128729074 0.16 PBX3
 pre-B-cell leukemia homeobox 3
 101448
 0.08
chr17_79372410_79373082 0.16 RP11-1055B8.7
 BAH and coiled-coil domain-containing protein 1
 794
 0.45
chr6_35337873_35338102 0.16 PPARD
 peroxisome proliferator-activated receptor delta
 27585
 0.16
chr1_94701176_94701460 0.16 ARHGAP29
 Rho GTPase activating protein 29
 1803
 0.43

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 0.4 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.5 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.4 GO:0051503 adenine nucleotide transport(GO:0051503)
0.1 0.2 GO:0046449 allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1 0.3 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.2 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 0.2 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1 0.2 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.2 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 0.3 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 0.1 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.1 0.1 GO:0048343 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.1 0.2 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 0.2 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0014889 muscle atrophy(GO:0014889)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.3 GO:0032906 transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.0 0.1 GO:0060242 contact inhibition(GO:0060242)
0.0 0.3 GO:0060347 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.2 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:1903054 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.5 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0010755 regulation of plasminogen activation(GO:0010755) negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0051927 obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.0 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.1 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0 0.1 GO:0060841 venous blood vessel development(GO:0060841)
0.0 0.0 GO:0001743 optic placode formation(GO:0001743)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0 0.1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0 0.1 GO:0000492 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.0 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:0008049 male courtship behavior(GO:0008049)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.0 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.5 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.0 GO:0071698 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.0 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.3 GO:0030325 adrenal gland development(GO:0030325)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.0 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.1 GO:0032730 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0 0.1 GO:0007100 mitotic centrosome separation(GO:0007100)
0.0 0.1 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.3 GO:0001893 maternal placenta development(GO:0001893)
0.0 0.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0072070 loop of Henle development(GO:0072070)
0.0 0.1 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.1 GO:0048520 positive regulation of behavior(GO:0048520)
0.0 0.0 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.0 GO:0019511 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.1 GO:0043584 nose development(GO:0043584)
0.0 0.1 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.0 GO:0071462 cellular response to water stimulus(GO:0071462)
0.0 0.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.0 GO:1903519 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.0 GO:0060206 estrous cycle phase(GO:0060206)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.0 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.0 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.0 GO:0006573 valine metabolic process(GO:0006573)
0.0 0.0 GO:0042109 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0 0.0 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.0 GO:0009648 photoperiodism(GO:0009648)
0.0 0.0 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.0 GO:0043032 positive regulation of macrophage activation(GO:0043032)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.0 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.0 GO:0035625 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 0.0 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.0 GO:0042482 positive regulation of odontogenesis(GO:0042482)
0.0 0.0 GO:0050955 thermoception(GO:0050955)
0.0 0.2 GO:0043113 receptor clustering(GO:0043113)
0.0 0.0 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.0 GO:0071436 sodium ion export(GO:0071436)
0.0 0.0 GO:0051590 positive regulation of neurotransmitter transport(GO:0051590)
0.0 0.0 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0032230 positive regulation of synaptic transmission, GABAergic(GO:0032230)
0.0 0.1 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.1 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 0.1 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.1 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.1 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.1 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0 0.0 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.0 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.2 GO:0051353 positive regulation of oxidoreductase activity(GO:0051353)
0.0 0.0 GO:0015825 L-serine transport(GO:0015825)
0.0 0.0 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.1 GO:0008088 axo-dendritic transport(GO:0008088)
0.0 0.0 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.1 GO:0045885 obsolete positive regulation of survival gene product expression(GO:0045885)
0.0 0.1 GO:0030728 ovulation(GO:0030728)
0.0 0.1 GO:0030033 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.0 GO:0016246 RNA interference(GO:0016246)
0.0 0.0 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.0 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.0 GO:0051580 regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0 0.0 GO:2000189 regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.6 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.1 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.0 0.0 GO:0021860 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.0 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.0 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.4 GO:0007272 ensheathment of neurons(GO:0007272) axon ensheathment(GO:0008366)
0.0 0.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.0 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 0.0 GO:0045007 depurination(GO:0045007)
0.0 0.0 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0001660 fever generation(GO:0001660)
0.0 0.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.0 GO:0046113 nucleobase catabolic process(GO:0046113)
0.0 0.1 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.0 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.0 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.0 0.0 GO:0032455 nerve growth factor processing(GO:0032455)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.6 GO:0005916 fascia adherens(GO:0005916)
0.1 0.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.4 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.3 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.0 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0016585 obsolete chromatin remodeling complex(GO:0016585)
0.0 0.6 GO:0043197 dendritic spine(GO:0043197)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.0 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.0 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0031105 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0030686 90S preribosome(GO:0030686)
0.0 0.6 GO:0030426 growth cone(GO:0030426)
0.0 0.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 1.0 GO:0030016 myofibril(GO:0030016)
0.0 0.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.3 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0030172 troponin C binding(GO:0030172)
0.1 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.2 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 0.4 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.5 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.2 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.3 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.4 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.2 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.1 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.2 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.2 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0034190 apolipoprotein receptor binding(GO:0034190)
0.0 0.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.0 GO:0004946 bombesin receptor activity(GO:0004946)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 1.3 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.0 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.0 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.0 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.0 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.0 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0043395 proteoglycan binding(GO:0043394) heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.0 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0045502 dynein binding(GO:0045502)
0.0 0.0 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.0 0.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.8 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.1 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.0 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0 0.1 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.2 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.1 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME GABA B RECEPTOR ACTIVATION Genes involved in GABA B receptor activation
0.0 0.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions