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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PBX1

Z-value: 0.88

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Transcription factors associated with PBX1

Gene Symbol	Gene ID	Gene Info
PBX1 Ensembl NCBI GeneCards UniProt	ENSG00000185630.14	PBX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PBX1	chr1_164532740_164533333	994	0.668070	0.90	1.0e-03	Click!
PBX1	chr1_164545287_164545502	13352	0.253667	0.84	5.1e-03	Click!
PBX1	chr1_164532131_164532342	194	0.965561	0.75	1.9e-02	Click!
PBX1	chr1_164530790_164530941	1177	0.609321	0.75	2.0e-02	Click!
PBX1	chr1_164545611_164545762	13644	0.252692	0.73	2.6e-02	Click!

Activity of the PBX1 motif across conditions

Conditions sorted by the z-value of the PBX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_54456456_54456818	0.39	GPX8	glutathione peroxidase 8 (putative)	639	0.58
chrX_34673939_34674563	0.37	TMEM47	transmembrane protein 47	1154	0.68
chr12_85305887_85306488	0.36	SLC6A15	solute carrier family 6 (neutral amino acid transporter), member 15	384	0.92
chr7_28429293_28429606	0.35	CREB5	cAMP responsive element binding protein 5	19557	0.28
chr9_134875172_134875430	0.35	MED27	mediator complex subunit 27	79952	0.1
chr10_33620428_33620906	0.33	NRP1	neuropilin 1	2643	0.37
chr2_3625481_3625934	0.33	ENSG00000252531	.	2453	0.16
chr5_102202832_102203172	0.32	PAM	peptidylglycine alpha-amidating monooxygenase	1182	0.66
chr7_46330968_46331124	0.32	ENSG00000239004	.	316009	0.01
chr6_121756849_121757212	0.32	GJA1	gap junction protein, alpha 1, 43kDa	192	0.94
chr8_19148668_19149118	0.31	SH2D4A	SH2 domain containing 4A	22235	0.28
chr10_73725086_73725706	0.31	CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	1273	0.55
chr6_73263483_73264009	0.30	KCNQ5	potassium voltage-gated channel, KQT-like subfamily, member 5	67774	0.12
chr11_12699031_12699547	0.30	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	2239	0.43
chr8_126557595_126557859	0.30	ENSG00000266452	.	100920	0.08
chr14_55144332_55144669	0.29	SAMD4A	sterile alpha motif domain containing 4A	77051	0.1
chr9_18474095_18474958	0.29	ADAMTSL1	ADAMTS-like 1	295	0.95
chr18_53214040_53214242	0.29	TCF4	transcription factor 4	36141	0.18
chr6_165722551_165723097	0.28	C6orf118	chromosome 6 open reading frame 118	272	0.95
chr7_111002999_111003219	0.28	IMMP2L	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	29862	0.26
chr4_114899439_114899761	0.27	ARSJ	arylsulfatase family, member J	552	0.84
chr2_74968036_74968578	0.27	SEMA4F	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F	86869	0.07
chr15_35598532_35598857	0.27	ENSG00000265102	.	65871	0.14
chr1_164532740_164533333	0.26	PBX1	pre-B-cell leukemia homeobox 1	994	0.67
chr1_235904828_235905136	0.26	LYST	lysosomal trafficking regulator	10489	0.24
chr4_183066487_183066672	0.26	AC108142.1		177	0.77
chr2_190044545_190044696	0.26	COL5A2	collagen, type V, alpha 2	15	0.98
chr3_87039220_87039752	0.24	VGLL3	vestigial like 3 (Drosophila)	366	0.93
chr11_122072235_122072431	0.24	ENSG00000207994	.	49317	0.12
chr4_177931083_177931234	0.24	ENSG00000222859	.	171438	0.03
chr21_28215601_28215791	0.24	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	163	0.97
chr5_42423266_42423460	0.24	GHR	growth hormone receptor	516	0.88
chr4_30726767_30727321	0.24	PCDH7	protocadherin 7	3067	0.38
chr1_51726454_51726959	0.24	RP11-296A18.6		5040	0.16
chr7_78398482_78399243	0.24	MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	1534	0.56
chr6_139116835_139117557	0.23	ECT2L	epithelial cell transforming sequence 2 oncogene-like	61	0.98
chr5_174162455_174162926	0.23	MSX2	msh homeobox 2	11085	0.25
chr13_38444595_38444746	0.23	TRPC4	transient receptor potential cation channel, subfamily C, member 4	108	0.98
chr12_88971091_88971358	0.23	KITLG	KIT ligand	3014	0.3
chr3_153840530_153840806	0.23	ARHGEF26	Rho guanine nucleotide exchange factor (GEF) 26	1439	0.37
chr11_125929052_125929203	0.23	CDON	cell adhesion associated, oncogene regulated	3579	0.26
chr12_14537227_14537378	0.23	ATF7IP	activating transcription factor 7 interacting protein	696	0.76
chr10_33299780_33299931	0.23	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	5135	0.26
chr7_54731814_54732170	0.23	ENSG00000200471	.	43274	0.17
chr4_177192718_177192869	0.23	ASB5	ankyrin repeat and SOCS box containing 5	2420	0.32
chrX_11456470_11456766	0.22	ARHGAP6	Rho GTPase activating protein 6	10725	0.3
chr6_169652381_169652976	0.22	THBS2	thrombospondin 2	432	0.89
chr20_14314803_14314963	0.22	FLRT3	fibronectin leucine rich transmembrane protein 3	3371	0.3
chr13_38172711_38172913	0.22	POSTN	periostin, osteoblast specific factor	51	0.99
chr15_72529055_72529849	0.22	PKM	pyruvate kinase, muscle	5288	0.17
chrX_33228916_33229133	0.22	DMD	dystrophin	405	0.92
chr2_221969079_221969387	0.22	EPHA4	EPH receptor A4	398047	0.01
chr1_147148877_147149210	0.22	ACP6	acid phosphatase 6, lysophosphatidic	6425	0.22
chr8_37556496_37556710	0.22	ZNF703	zinc finger protein 703	3334	0.17
chr3_55513844_55514078	0.22	WNT5A	wingless-type MMTV integration site family, member 5A	1263	0.55
chr11_35512807_35513203	0.22	PAMR1	peptidase domain containing associated with muscle regeneration 1	34146	0.18
chr5_17021245_17021396	0.21	BASP1	brain abundant, membrane attached signal protein 1	44387	0.15
chr12_31480010_31480161	0.21	FAM60A	family with sequence similarity 60, member A	93	0.96
chr8_119016675_119016955	0.21	EXT1	exostosin glycosyltransferase 1	105838	0.08
chr1_100112033_100112261	0.21	PALMD	palmdelphin	398	0.9
chr1_95009725_95009876	0.21	F3	coagulation factor III (thromboplastin, tissue factor)	2444	0.41
chr4_187646262_187646501	0.21	FAT1	FAT atypical cadherin 1	1372	0.58
chr3_86992006_86992157	0.21	VGLL3	vestigial like 3 (Drosophila)	47771	0.2
chr1_95388573_95389173	0.21	CNN3	calponin 3, acidic	2464	0.27
chr3_29735259_29735935	0.21	RBMS3-AS2	RBMS3 antisense RNA 2	51297	0.19
chr8_106743100_106743756	0.21	RP11-642D21.2		45435	0.16
chr12_54089934_54090280	0.21	CALCOCO1	calcium binding and coiled-coil domain 1	18306	0.14
chr3_55514769_55515136	0.21	WNT5A	wingless-type MMTV integration site family, member 5A	272	0.94
chr7_112626035_112626431	0.21	C7orf60	chromosome 7 open reading frame 60	46262	0.17
chr7_80377911_80378104	0.21	CD36	CD36 molecule (thrombospondin receptor)	75315	0.12
chr3_116163075_116163431	0.21	LSAMP	limbic system-associated membrane protein	577	0.84
chr1_19947101_19947252	0.21	NBL1	neuroblastoma 1, DAN family BMP antagonist	19872	0.12
chr7_80546807_80546971	0.21	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	1610	0.56
chr10_89307360_89307659	0.21	ENSG00000222192	.	15434	0.21
chr8_89337580_89337731	0.21	RP11-586K2.1		1410	0.42
chrX_28605228_28605520	0.21	IL1RAPL1	interleukin 1 receptor accessory protein-like 1	142	0.98
chr16_80840676_80840857	0.20	CDYL2	chromodomain protein, Y-like 2	2540	0.35
chr8_38205354_38205751	0.20	RP11-513D5.2		12053	0.13
chr3_87383057_87383208	0.20	POU1F1	POU class 1 homeobox 1	57395	0.15
chr20_17553764_17553929	0.20	DSTN	destrin (actin depolymerizing factor)	3119	0.21
chr10_36184684_36184984	0.20	FZD8	frizzled family receptor 8	254472	0.02
chr2_64876893_64877273	0.20	SERTAD2	SERTA domain containing 2	3964	0.28
chr12_88972313_88972545	0.20	KITLG	KIT ligand	1809	0.39
chr16_2177423_2177723	0.20	ENSG00000200059	.	4279	0.06
chr2_235933296_235933447	0.20	SH3BP4	SH3-domain binding protein 4	29887	0.26
chr6_169653692_169653887	0.20	THBS2	thrombospondin 2	350	0.92
chr18_25751825_25751976	0.20	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	5510	0.36
chr3_120168336_120168615	0.20	FSTL1	follistatin-like 1	1363	0.54
chr9_112813940_112814168	0.20	AKAP2	A kinase (PRKA) anchor protein 2	3078	0.38
chr9_93058938_93059089	0.20	ENSG00000263967	.	273196	0.02
chr10_65473071_65473288	0.20	REEP3	receptor accessory protein 3	192056	0.03
chr22_40894900_40895196	0.20	RP4-591N18.2		22756	0.15
chr22_39711605_39711921	0.19	ENSG00000209482	.	451	0.66
chr17_69629060_69629258	0.19	ENSG00000222563	.	321850	0.01
chr1_95390838_95390989	0.19	CNN3	calponin 3, acidic	424	0.81
chr6_28641788_28642196	0.19	ENSG00000272278	.	25950	0.18
chr13_40176110_40176261	0.19	LHFP	lipoma HMGIC fusion partner	1123	0.55
chr18_57362819_57362970	0.19	RP11-2N1.2		797	0.55
chr12_54391177_54391923	0.19	HOXC-AS2	HOXC cluster antisense RNA 2	981	0.22
chr7_116167584_116167883	0.19	CAV1	caveolin 1, caveolae protein, 22kDa	1386	0.37
chr2_111206913_111207281	0.19	RP13-1039J1.3		278	0.91
chr11_27722222_27723091	0.19	BDNF	brain-derived neurotrophic factor	56	0.98
chr7_134465998_134466492	0.19	CALD1	caldesmon 1	1816	0.49
chr18_48571368_48571694	0.19	SMAD4	SMAD family member 4	202	0.96
chr5_145318270_145318548	0.19	SH3RF2	SH3 domain containing ring finger 2	969	0.66
chr11_101991103_101991395	0.19	YAP1	Yes-associated protein 1	8004	0.18
chr21_35899555_35899706	0.19	RCAN1	regulator of calcineurin 1	369	0.87
chr10_8201743_8201894	0.19	GATA3	GATA binding protein 3	105049	0.08
chr10_8635845_8635996	0.19	ENSG00000212505	.	62874	0.16
chr2_151339584_151339865	0.19	RND3	Rho family GTPase 3	2172	0.49
chr6_3156631_3156782	0.19	TUBB2A	tubulin, beta 2A class IIa	1054	0.43
chr19_20149056_20149207	0.19	ZNF682	zinc finger protein 682	883	0.56
chr14_23447971_23448151	0.19	AJUBA	ajuba LIM protein	1115	0.25
chr6_44424385_44424803	0.19	ENSG00000266619	.	21216	0.17
chrX_45482024_45482567	0.19	ENSG00000207870	.	123399	0.06
chr12_77457624_77458072	0.19	E2F7	E2F transcription factor 7	1482	0.56
chr3_149298860_149299373	0.18	WWTR1	WW domain containing transcription regulator 1	5077	0.23
chr1_20810069_20810220	0.18	CAMK2N1	calcium/calmodulin-dependent protein kinase II inhibitor 1	2569	0.29
chr15_75942874_75943101	0.18	SNX33	sorting nexin 33	890	0.37
chr15_40339032_40339183	0.18	SRP14	signal recognition particle 14kDa (homologous Alu RNA binding protein)	7718	0.16
chr1_27425556_27426394	0.18	SLC9A1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	54998	0.1
chr8_42063953_42065062	0.18	PLAT	plasminogen activator, tissue	576	0.71
chr11_121968787_121969071	0.18	ENSG00000207971	.	1623	0.3
chr13_98826337_98826632	0.18	RNF113B	ring finger protein 113B	3035	0.21
chr1_85064609_85064886	0.18	CTBS	chitobiase, di-N-acetyl-	24600	0.17
chr11_27739578_27739815	0.18	BDNF	brain-derived neurotrophic factor	1598	0.49
chr6_79314382_79314680	0.18	IRAK1BP1	interleukin-1 receptor-associated kinase 1 binding protein 1	262658	0.02
chr1_209577581_209577868	0.18	ENSG00000230937	.	27754	0.24
chr1_103571993_103572213	0.18	COL11A1	collagen, type XI, alpha 1	1631	0.56
chr1_172110530_172111247	0.18	ENSG00000207949	.	2841	0.22
chr8_141436376_141436676	0.18	TRAPPC9	trafficking protein particle complex 9	24503	0.23
chr9_134554105_134554369	0.18	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	30992	0.18
chr20_14317720_14318261	0.18	FLRT3	fibronectin leucine rich transmembrane protein 3	264	0.94
chr4_74316638_74316988	0.18	AFP	alpha-fetoprotein	14849	0.2
chr7_17411558_17411747	0.18	ENSG00000199473	.	1298	0.57
chr12_90485372_90485572	0.18	ENSG00000252823	.	337636	0.01
chr11_122037044_122037237	0.18	ENSG00000207994	.	14124	0.17
chr17_16286606_16286915	0.18	RP11-138I1.4		777	0.51
chr9_22683479_22683652	0.18	DMRTA1	DMRT-like family A1	236725	0.02
chr14_35629027_35629224	0.18	KIAA0391	KIAA0391	37160	0.15
chr11_6340007_6340271	0.18	PRKCDBP	protein kinase C, delta binding protein	1623	0.33
chr5_35130063_35130359	0.17	PRLR	prolactin receptor	235	0.95
chr18_18697894_18698383	0.17	ENSG00000251886	.	2329	0.32
chr12_100628376_100628664	0.17	ENSG00000206790	.	23048	0.11
chr2_224477610_224477904	0.17	SCG2	secretogranin II	10536	0.31
chr4_177712658_177713139	0.17	VEGFC	vascular endothelial growth factor C	983	0.71
chr16_65152808_65153250	0.17	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	2804	0.44
chr3_159847220_159847374	0.17	IL12A-AS1	IL12A antisense RNA 1	77582	0.09
chr8_20126437_20126669	0.17	LZTS1	leucine zipper, putative tumor suppressor 1	13750	0.19
chr1_64096235_64096386	0.17	PGM1	phosphoglucomutase 1	7546	0.2
chr3_171814831_171814982	0.17	FNDC3B	fibronectin type III domain containing 3B	29858	0.23
chr4_110910630_110910781	0.17	ENSG00000207260	.	2776	0.34
chr15_96878987_96879612	0.17	ENSG00000222651	.	2809	0.21
chr4_144303651_144303881	0.17	GAB1	GRB2-associated binding protein 1	668	0.76
chr22_46462951_46463814	0.17	RP6-109B7.4		2389	0.16
chr6_52532294_52532590	0.17	RP1-152L7.5		2370	0.29
chr2_30888986_30889287	0.17	CAPN13	calpain 13	141175	0.05
chr3_99593001_99593152	0.17	FILIP1L	filamin A interacting protein 1-like	1872	0.43
chr12_119617594_119617745	0.17	HSPB8	heat shock 22kDa protein 8	274	0.89
chr8_89338361_89338512	0.17	RP11-586K2.1		629	0.66
chr12_13025379_13025989	0.17	GPRC5A	G protein-coupled receptor, family C, group 5, member A	18032	0.14
chr8_119120675_119121215	0.17	EXT1	exostosin glycosyltransferase 1	1708	0.54
chrX_16840604_16840755	0.17	RBBP7	retinoblastoma binding protein 7	29509	0.14
chr1_32168571_32169014	0.17	COL16A1	collagen, type XVI, alpha 1	976	0.48
chr7_41737032_41737183	0.17	INHBA	inhibin, beta A	3100	0.25
chr14_53416235_53416562	0.17	FERMT2	fermitin family member 2	888	0.69
chr13_100635534_100635685	0.17	ZIC2	Zic family member 2	1583	0.38
chr5_9047596_9047771	0.17	ENSG00000266415	.	6324	0.29
chr11_93865075_93865400	0.17	PANX1	pannexin 1	3142	0.34
chr3_61549164_61549336	0.17	PTPRG	protein tyrosine phosphatase, receptor type, G	1665	0.55
chr17_36623721_36623872	0.17	ARHGAP23	Rho GTPase activating protein 23	4384	0.19
chr13_50650853_50651004	0.17	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	5379	0.18
chr1_87244034_87244185	0.17	SH3GLB1	SH3-domain GRB2-like endophilin B1	73531	0.09
chr18_74798828_74799607	0.17	MBP	myelin basic protein	18000	0.27
chr15_81614829_81615120	0.16	STARD5	StAR-related lipid transfer (START) domain containing 5	1492	0.33
chr19_54538995_54539193	0.16	VSTM1	V-set and transmembrane domain containing 1	22583	0.08
chr12_78334342_78334902	0.16	NAV3	neuron navigator 3	25434	0.27
chr3_156409477_156409860	0.16	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	10713	0.23
chr10_61385710_61385861	0.16	SLC16A9	solute carrier family 16, member 9	84052	0.11
chr6_121757423_121758012	0.16	GJA1	gap junction protein, alpha 1, 43kDa	879	0.59
chr21_43085116_43085274	0.16	LINC00112	long intergenic non-protein coding RNA 112	51401	0.12
chr22_37828954_37829105	0.16	ELFN2	extracellular leucine-rich repeat and fibronectin type III domain containing 2	5524	0.16
chr1_183132842_183132993	0.16	LAMC2	laminin, gamma 2	22456	0.18
chr14_50453745_50453978	0.16	C14orf182	chromosome 14 open reading frame 182	20377	0.16
chr3_65941462_65941807	0.16	MAGI1-IT1	MAGI1 intronic transcript 1 (non-protein coding)	1401	0.43
chr19_18655304_18655455	0.16	FKBP8	FK506 binding protein 8, 38kDa	492	0.6
chr22_31033608_31033759	0.16	SLC35E4	solute carrier family 35, member E4	1173	0.36
chr1_154597059_154597346	0.16	ADAR	adenosine deaminase, RNA-specific	3238	0.19
chr22_46480425_46480827	0.16	FLJ27365	hsa-mir-4763	1257	0.28
chr4_184880881_184881125	0.16	STOX2	storkhead box 2	409	0.89
chr20_30292538_30292716	0.16	AL160175.1		16374	0.12
chr7_137402579_137403024	0.16	DGKI	diacylglycerol kinase, iota	128481	0.05
chr3_98619314_98619465	0.16	DCBLD2	discoidin, CUB and LCCL domain containing 2	626	0.66
chr17_750320_750517	0.16	NXN	nucleoredoxin	16919	0.14
chr7_27142394_27142575	0.16	HOXA2	homeobox A2	54	0.93
chrX_114467670_114468385	0.16	LRCH2	leucine-rich repeats and calponin homology (CH) domain containing 2	601	0.77
chr9_128728923_128729074	0.16	PBX3	pre-B-cell leukemia homeobox 3	101448	0.08
chr17_79372410_79373082	0.16	RP11-1055B8.7	BAH and coiled-coil domain-containing protein 1	794	0.45
chr6_35337873_35338102	0.16	PPARD	peroxisome proliferator-activated receptor delta	27585	0.16
chr1_94701176_94701460	0.16	ARHGAP29	Rho GTPase activating protein 29	1803	0.43

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1	0.4	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.1	0.5	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.4	GO:0051503	adenine nucleotide transport(GO:0051503)
0.1	0.2	GO:0046449	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1	0.3	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.2	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.1	0.2	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1	0.2	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.2	GO:0033024	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1	0.3	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.2	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.1	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.1	0.1	GO:0048343	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.1	0.2	GO:0021569	rhombomere 3 development(GO:0021569)
0.1	0.2	GO:0002551	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.3	GO:0032906	transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.3	GO:0060347	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.2	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:1903054	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.2	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.5	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0010755	regulation of plasminogen activation(GO:0010755) negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.2	GO:0051927	obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.0	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.1	GO:0006531	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.1	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.2	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0060841	venous blood vessel development(GO:0060841)
0.0	0.0	GO:0001743	optic placode formation(GO:0001743)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.2	GO:0010799	regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0	0.1	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0	0.1	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0090206	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.5	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.2	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.0	GO:0071698	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.0	GO:0010996	response to auditory stimulus(GO:0010996)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.3	GO:0030325	adrenal gland development(GO:0030325)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0032730	regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.1	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.1	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.3	GO:0001893	maternal placenta development(GO:0001893)
0.0	0.2	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0072070	loop of Henle development(GO:0072070)
0.0	0.1	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0048520	positive regulation of behavior(GO:0048520)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.0	GO:0019511	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0043584	nose development(GO:0043584)
0.0	0.1	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.0	GO:0071462	cellular response to water stimulus(GO:0071462)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.0	GO:1903519	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.0	GO:0060206	estrous cycle phase(GO:0060206)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.0	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.0	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.0	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.0	GO:0009648	photoperiodism(GO:0009648)
0.0	0.0	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.0	GO:0043032	positive regulation of macrophage activation(GO:0043032)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.0	GO:0032224	positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.0	GO:0035625	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.0	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.0	GO:0042482	positive regulation of odontogenesis(GO:0042482)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.2	GO:0043113	receptor clustering(GO:0043113)
0.0	0.0	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0051590	positive regulation of neurotransmitter transport(GO:0051590)
0.0	0.0	GO:0030210	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0032230	positive regulation of synaptic transmission, GABAergic(GO:0032230)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.1	GO:0007263	nitric oxide mediated signal transduction(GO:0007263)
0.0	0.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.1	GO:0002069	columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.2	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.0	GO:0032148	activation of protein kinase B activity(GO:0032148)
0.0	0.2	GO:0051353	positive regulation of oxidoreductase activity(GO:0051353)
0.0	0.0	GO:0015825	L-serine transport(GO:0015825)
0.0	0.0	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.0	0.1	GO:0008088	axo-dendritic transport(GO:0008088)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.1	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.1	GO:0030728	ovulation(GO:0030728)
0.0	0.1	GO:0030033	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.0	GO:0016246	RNA interference(GO:0016246)
0.0	0.0	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.0	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.0	0.0	GO:0051580	regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0	0.0	GO:2000189	regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.6	GO:0030198	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0	0.1	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.0	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.0	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.4	GO:0007272	ensheathment of neurons(GO:0007272) axon ensheathment(GO:0008366)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.0	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.0	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0001660	fever generation(GO:0001660)
0.0	0.0	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0034384	high-density lipoprotein particle clearance(GO:0034384)
0.0	0.0	GO:0032455	nerve growth factor processing(GO:0032455)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.6	GO:0005916	fascia adherens(GO:0005916)
0.1	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	0.4	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1	0.2	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.3	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.3	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.3	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.3	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.2	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	1.1	GO:0005604	basement membrane(GO:0005604)
0.0	0.1	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.0	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.3	GO:0005811	lipid particle(GO:0005811)
0.0	0.2	GO:0005581	collagen trimer(GO:0005581)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.0	0.6	GO:0043197	dendritic spine(GO:0043197)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.0	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.0	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0030686	90S preribosome(GO:0030686)
0.0	0.6	GO:0030426	growth cone(GO:0030426)
0.0	0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	1.0	GO:0030016	myofibril(GO:0030016)
0.0	0.2	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.3	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.3	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.3	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0030172	troponin C binding(GO:0030172)
0.1	0.2	GO:0016842	amidine-lyase activity(GO:0016842)
0.1	0.2	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.1	0.4	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.2	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.5	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.5	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.3	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.7	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.2	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.2	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.3	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.3	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.3	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.4	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.2	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.3	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.4	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.0	0.2	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.1	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0034584	piRNA binding(GO:0034584)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0042056	chemoattractant activity(GO:0042056)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.2	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.1	GO:0001012	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	1.1	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	1.3	GO:0008201	heparin binding(GO:0008201)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0050694	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.0	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.0	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.0	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.0	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0043395	proteoglycan binding(GO:0043394) heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.0	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.0	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0045502	dynein binding(GO:0045502)
0.0	0.0	GO:0005415	nucleoside:sodium symporter activity(GO:0005415)
0.0	0.1	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.0	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.1	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	1.8	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.0	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.3	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.0	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.4	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	0.2	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.3	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.1	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	0.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	0.2	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.4	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.4	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.4	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.3	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.6	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.4	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	1.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.5	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	0.1	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0	0.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.0	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.1	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.1	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.2	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	0.2	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.1	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	0.3	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.0	0.3	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.1	REACTOME GABA B RECEPTOR ACTIVATION	Genes involved in GABA B receptor activation
0.0	0.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions