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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for PBX3

Z-value: 1.16

Motif logo

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Transcription factors associated with PBX3

Gene Symbol Gene ID Gene Info
PBX3
ENSG00000167081.12 PBX homeobox 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr9_128514663_128514814PBX342600.307116-0.932.8e-04Click!
chr9_128664438_128664589PBX3369630.227213-0.925.2e-04Click!
chr9_128524004_128524155PBX3136010.262021-0.917.2e-04Click!
chr9_128516456_128516607PBX360530.285353-0.881.9e-03Click!
chr9_128512019_128512257PBX316600.479975-0.872.6e-03Click!

Activity of the PBX3 motif across conditions

Conditions sorted by the z-value of the PBX3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_46612034_46612360 0.94 SLC38A1
 solute carrier family 38, member 1
 49287
 0.18
chr22_40298890_40299260 0.83 GRAP2
 GRB2-related adaptor protein 2
 1962
 0.3
chr7_150148386_150148563 0.76 GIMAP8
 GTPase, IMAP family member 8
 756
 0.63
chrX_135731409_135731662 0.72 CD40LG
 CD40 ligand
 1149
 0.47
chr13_24827167_24827318 0.72 SPATA13-AS1
 SPATA13 antisense RNA 1
 1335
 0.33
chr9_130539941_130540132 0.71 SH2D3C
 SH2 domain containing 3C
 984
 0.33
chr1_154927193_154927621 0.70 PBXIP1
 pre-B-cell leukemia homeobox interacting protein 1
 1173
 0.25
chr5_35859258_35859647 0.69 IL7R
 interleukin 7 receptor
 2458
 0.3
chr12_55362139_55362302 0.68 TESPA1
 thymocyte expressed, positive selection associated 1
 5118
 0.26
chr14_91866311_91866542 0.68 CCDC88C
 coiled-coil domain containing 88C
 17264
 0.22
chr6_149805654_149805958 0.65 ZC3H12D
 zinc finger CCCH-type containing 12D
 320
 0.87
chr1_156785806_156786457 0.64 SH2D2A
 SH2 domain containing 2A
 495
 0.51
chr19_39825870_39826313 0.64 GMFG
 glia maturation factor, gamma
 554
 0.58
chr16_21519015_21519166 0.62 ENSG00000265462
 .
 1634
 0.33
chr20_52199257_52199767 0.62 ZNF217
 zinc finger protein 217
 124
 0.96
chr17_75663137_75663644 0.62 SEPT9
 septin 9
 185395
 0.03
chr14_22969065_22969423 0.61 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 13073
 0.1
chr1_239883177_239883989 0.60 CHRM3
 cholinergic receptor, muscarinic 3
 740
 0.59
chr21_15917916_15918619 0.59 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 395
 0.89
chr17_76128814_76128979 0.58 TMC6
 transmembrane channel-like 6
 408
 0.73
chr14_22974481_22974956 0.57 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 18547
 0.09
chr10_129861850_129862130 0.56 PTPRE
 protein tyrosine phosphatase, receptor type, E
 16156
 0.26
chr5_177236761_177236962 0.56 FAM153A
 family with sequence similarity 153, member A
 26462
 0.14
chr6_159464766_159465080 0.56 TAGAP
 T-cell activation RhoGTPase activating protein
 1127
 0.51
chr13_99910339_99910626 0.56 GPR18
 G protein-coupled receptor 18
 146
 0.96
chr15_55547653_55548107 0.56 RAB27A
 RAB27A, member RAS oncogene family
 6647
 0.22
chr18_13383462_13383613 0.56 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 984
 0.5
chr11_102192518_102192994 0.55 BIRC3
 baculoviral IAP repeat containing 3
 3196
 0.22
chr5_175461188_175461339 0.55 THOC3
 THO complex 3
 420
 0.79
chr2_204801338_204802214 0.55 ICOS
 inducible T-cell co-stimulator
 273
 0.95
chr11_46354220_46354463 0.55 DGKZ
 diacylglycerol kinase, zeta
 114
 0.96
chr22_50631230_50631436 0.54 TRABD
 TraB domain containing
 110
 0.82
chr16_81748402_81748687 0.54 PLCG2
 phospholipase C, gamma 2 (phosphatidylinositol-specific)
 24158
 0.24
chr2_235362717_235362976 0.52 ARL4C
 ADP-ribosylation factor-like 4C
 42398
 0.22
chr6_35279100_35279566 0.50 DEF6
 differentially expressed in FDCP 6 homolog (mouse)
 1818
 0.34
chr22_40781561_40781851 0.50 RP5-1042K10.10
2515
 0.24
chr14_22471633_22471925 0.49 ENSG00000238634
 .
 139108
 0.04
chr11_65379543_65379824 0.49 MAP3K11
 mitogen-activated protein kinase kinase kinase 11
 911
 0.31
chr9_36142717_36143534 0.48 GLIPR2
 GLI pathogenesis-related 2
 6383
 0.2
chr1_117342787_117343202 0.48 CD2
 CD2 molecule
 45905
 0.14
chr2_182174449_182174635 0.48 ENSG00000266705
 .
 4163
 0.36
chr11_121329971_121330303 0.48 RP11-730K11.1
6415
 0.25
chr19_16479476_16479627 0.48 EPS15L1
 epidermal growth factor receptor pathway substrate 15-like 1
 6787
 0.16
chr19_18414393_18414628 0.47 LSM4
 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
 12559
 0.09
chr5_35859676_35859963 0.47 IL7R
 interleukin 7 receptor
 2825
 0.28
chr1_169665907_169666062 0.47 SELL
 selectin L
 14855
 0.19
chr11_118213949_118214100 0.47 CD3D
 CD3d molecule, delta (CD3-TCR complex)
 565
 0.54
chr2_206809495_206809646 0.47 ENSG00000201875
 .
 44216
 0.13
chr14_91707602_91707801 0.46 CTD-2547L24.3
 HCG1816139; Uncharacterized protein
 1402
 0.37
chrX_44203680_44203969 0.46 EFHC2
 EF-hand domain (C-terminal) containing 2
 906
 0.71
chr11_2323777_2324127 0.45 TSPAN32
 tetraspanin 32
 1
 0.92
chr17_28033493_28033909 0.44 RP11-82O19.1
54420
 0.07
chr1_21620200_21620457 0.44 RP5-1071N3.1
545
 0.47
chr13_31311093_31311268 0.44 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 1535
 0.52
chr7_5572395_5572659 0.44 ACTB
 actin, beta
 2187
 0.2
chr5_100116307_100116504 0.43 ENSG00000221263
 .
 35864
 0.2
chr6_119131761_119131953 0.43 MCM9
 minichromosome maintenance complex component 9
 18559
 0.24
chr14_22895521_22895672 0.43 ENSG00000251002
 .
 6123
 0.13
chr21_46337373_46337524 0.43 ITGB2
 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
 3250
 0.13
chr11_64216918_64217087 0.42 AP003774.4
 HCG1652096, isoform CRA_a; Uncharacterized protein; cDNA FLJ37045 fis, clone BRACE2012185
 456
 0.79
chr10_8446299_8446474 0.42 ENSG00000212505
 .
 252408
 0.02
chr17_4389201_4389708 0.41 RP13-580F15.2
194
 0.92
chr4_40203939_40204397 0.41 RHOH
 ras homolog family member H
 2204
 0.34
chr16_11677800_11677980 0.41 LITAF
 lipopolysaccharide-induced TNF factor
 2339
 0.3
chr16_30486681_30486832 0.41 ITGAL
 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
 1434
 0.16
chr1_207088744_207089040 0.41 FAIM3
 Fas apoptotic inhibitory molecule 3
 6320
 0.15
chr1_19804030_19804234 0.41 CAPZB
 capping protein (actin filament) muscle Z-line, beta
 6447
 0.18
chr12_55375935_55376187 0.41 TESPA1
 thymocyte expressed, positive selection associated 1
 439
 0.86
chr14_91834289_91834440 0.41 ENSG00000265856
 .
 34307
 0.17
chr16_68113033_68113320 0.41 NFATC3
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
 6071
 0.11
chr13_99960008_99960188 0.40 GPR183
 G protein-coupled receptor 183
 439
 0.84
chr1_145454503_145454819 0.40 TXNIP
 thioredoxin interacting protein
 15355
 0.1
chr2_69867626_69867777 0.39 AAK1
 AP2 associated kinase 1
 3085
 0.28
chr11_118094529_118095128 0.39 AMICA1
 adhesion molecule, interacts with CXADR antigen 1
 26
 0.97
chr10_70849708_70849969 0.39 SRGN
 serglycin
 1964
 0.33
chr1_19803053_19803337 0.39 CAPZB
 capping protein (actin filament) muscle Z-line, beta
 7384
 0.17
chr4_90227728_90227903 0.39 GPRIN3
 GPRIN family member 3
 1346
 0.6
chr17_143001_143152 0.39 RP11-1260E13.1
28107
 0.13
chr5_39200999_39201150 0.38 FYB
 FYN binding protein
 2055
 0.44
chr14_22865587_22865738 0.38 ENSG00000251002
 .
 36057
 0.11
chr1_111742376_111742661 0.38 DENND2D
 DENN/MADD domain containing 2D
 793
 0.38
chr16_85936780_85936931 0.38 IRF8
 interferon regulatory factor 8
 411
 0.88
chr10_5336313_5336469 0.38 AKR1C7P
 aldo-keto reductase family 1, member C7, pseudogene
 5958
 0.22
chr17_56421423_56421650 0.38 BZRAP1-AS1
 BZRAP1 antisense RNA 1
 6817
 0.11
chr14_22964891_22965136 0.37 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 8842
 0.1
chr7_99819175_99819326 0.37 ENSG00000222482
 .
 1507
 0.2
chr5_156698426_156698828 0.37 CYFIP2
 cytoplasmic FMR1 interacting protein 2
 2265
 0.23
chr5_39203555_39203988 0.37 FYB
 FYN binding protein
 642
 0.81
chr22_39547258_39547409 0.37 CBX7
 chromobox homolog 7
 1116
 0.46
chr3_185826921_185827162 0.36 ETV5
 ets variant 5
 140
 0.97
chr21_44166870_44167151 0.36 AP001627.1
5142
 0.26
chr4_2799841_2800188 0.36 SH3BP2
 SH3-domain binding protein 2
 277
 0.92
chr11_35194712_35194909 0.36 CD44
 CD44 molecule (Indian blood group)
 3308
 0.21
chrX_48793999_48794379 0.36 PIM2
 pim-2 oncogene
 17888
 0.08
chr19_14477270_14477421 0.36 CD97
 CD97 molecule
 14623
 0.15
chr5_66461571_66461722 0.36 MAST4
 microtubule associated serine/threonine kinase family member 4
 23384
 0.22
chr10_82220206_82220414 0.35 TSPAN14
 tetraspanin 14
 1252
 0.5
chr1_1136100_1136251 0.35 TNFRSF18
 tumor necrosis factor receptor superfamily, member 18
 4885
 0.08
chr2_96986640_96986853 0.35 AC021188.4
723
 0.57
chr2_197032904_197033284 0.35 STK17B
 serine/threonine kinase 17b
 2630
 0.28
chr18_9107105_9107411 0.35 NDUFV2
 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
 3178
 0.21
chr22_22089210_22089361 0.34 YPEL1
 yippee-like 1 (Drosophila)
 759
 0.55
chr19_22605163_22605314 0.34 ZNF98
 zinc finger protein 98
 79
 0.98
chr15_63798708_63798859 0.34 USP3
 ubiquitin specific peptidase 3
 1928
 0.4
chr2_240302618_240303103 0.34 HDAC4
 histone deacetylase 4
 19783
 0.17
chr14_99710276_99710624 0.34 AL109767.1
18835
 0.2
chr19_12512149_12512361 0.34 ZNF799
 zinc finger protein 799
 170
 0.92
chr3_30670169_30670603 0.34 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 22293
 0.26
chr16_27413508_27414237 0.34 IL21R
 interleukin 21 receptor
 377
 0.88
chrX_71321072_71321371 0.34 RGAG4
 retrotransposon gag domain containing 4
 30457
 0.14
chr5_137416910_137417200 0.34 WNT8A
 wingless-type MMTV integration site family, member 8A
 2526
 0.17
chr17_33541971_33542122 0.34 SLC35G3
 solute carrier family 35, member G3
 20634
 0.11
chr2_74432517_74432668 0.34 MTHFD2
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
 6849
 0.14
chr14_106950202_106950486 0.34 IGHVII-44-2
 immunoglobulin heavy variable (II)-44-2 (pseudogene)
 53
 0.89
chr8_91018652_91018803 0.34 DECR1
 2,4-dienoyl CoA reductase 1, mitochondrial
 4982
 0.24
chr13_99856162_99856313 0.34 ENSG00000201793
 .
 1725
 0.34
chr1_204941075_204941226 0.33 NFASC
 neurofascin
 9834
 0.21
chr12_66662591_66662742 0.33 RP11-335I12.2
11452
 0.15
chr2_27485345_27486489 0.33 SLC30A3
 solute carrier family 30 (zinc transporter), member 3
 178
 0.89
chr9_82185992_82186420 0.33 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 482
 0.9
chr14_75715883_75716034 0.33 RP11-293M10.2
10156
 0.15
chr7_50345819_50346403 0.33 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 1733
 0.5
chr16_23846602_23847146 0.33 PRKCB
 protein kinase C, beta
 448
 0.87
chr1_111423669_111423843 0.33 CD53
 CD53 molecule
 7980
 0.2
chr17_43487096_43487739 0.33 ARHGAP27
 Rho GTPase activating protein 27
 335
 0.82
chr7_21467616_21467934 0.33 SP4
 Sp4 transcription factor
 114
 0.97
chr6_126153129_126153280 0.33 NCOA7-AS1
 NCOA7 antisense RNA 1
 13200
 0.18
chr16_84582402_84582610 0.33 TLDC1
 TBC/LysM-associated domain containing 1
 5133
 0.21
chr1_168390803_168391087 0.32 ENSG00000207974
 .
 46183
 0.16
chr12_48551760_48551911 0.32 ASB8
 ankyrin repeat and SOCS box containing 8
 457
 0.75
chr19_6926549_6926700 0.32 RP11-1137G4.3
26598
 0.12
chr16_3116517_3116777 0.32 IL32
 interleukin 32
 834
 0.3
chr12_57441357_57441508 0.32 MYO1A
 myosin IA
 182
 0.9
chr22_17567910_17568443 0.32 IL17RA
 interleukin 17 receptor A
 2327
 0.26
chr2_128395227_128395389 0.32 LIMS2
 LIM and senescent cell antigen-like domains 2
 4398
 0.16
chr6_166954866_166955076 0.32 RPS6KA2
 ribosomal protein S6 kinase, 90kDa, polypeptide 2
 967
 0.56
chr4_6928559_6928859 0.31 TBC1D14
 TBC1 domain family, member 14
 16734
 0.16
chr1_26158794_26158945 0.31 RP1-317E23.7
244
 0.84
chr1_84902979_84903163 0.31 DNASE2B
 deoxyribonuclease II beta
 29158
 0.16
chr6_159074554_159074705 0.31 SYTL3
 synaptotagmin-like 3
 3583
 0.22
chr17_45297902_45298194 0.31 ENSG00000252088
 .
 40
 0.92
chr11_128566078_128566229 0.31 SENCR
 smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA
 235
 0.91
chr2_198651086_198651566 0.31 BOLL
 boule-like RNA-binding protein
 28
 0.98
chr9_117152254_117152405 0.31 AKNA
 AT-hook transcription factor
 1968
 0.35
chr14_100533458_100533776 0.31 EVL
 Enah/Vasp-like
 843
 0.55
chr15_74834439_74834753 0.31 ARID3B
 AT rich interactive domain 3B (BRIGHT-like)
 1078
 0.48
chr16_68403596_68403824 0.30 SMPD3
 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
 1198
 0.37
chr17_75606628_75606867 0.30 SEPT9
 septin 9
 128752
 0.05
chr19_42703347_42703984 0.30 ENSG00000265122
 .
 6435
 0.1
chr19_3036283_3036702 0.30 TLE2
 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
 6880
 0.13
chr17_43305439_43305590 0.30 CTD-2020K17.1
5925
 0.1
chr4_184642687_184643147 0.30 ENSG00000251739
 .
 15833
 0.17
chr18_24289152_24289303 0.30 ENSG00000265369
 .
 19734
 0.21
chr7_50351765_50352753 0.30 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 3941
 0.34
chrX_64917369_64917808 0.30 MSN
 moesin
 30051
 0.25
chr6_135450306_135450457 0.30 HBS1L
 HBS1-like (S. cerevisiae)
 26187
 0.17
chr5_39207439_39207590 0.30 FYB
 FYN binding protein
 4385
 0.32
chr9_95945997_95946357 0.30 WNK2
 WNK lysine deficient protein kinase 2
 1021
 0.58
chr10_126182799_126183006 0.29 LHPP
 phospholysine phosphohistidine inorganic pyrophosphate phosphatase
 32490
 0.16
chr2_106572142_106572293 0.29 AC009505.2
98584
 0.07
chr17_43302789_43303077 0.29 CTD-2020K17.1
3344
 0.12
chr17_17654361_17654512 0.29 RAI1-AS1
 RAI1 antisense RNA 1
 19699
 0.13
chrX_19815653_19816006 0.29 SH3KBP1
 SH3-domain kinase binding protein 1
 2040
 0.46
chr1_156933589_156933740 0.29 ARHGEF11
 Rho guanine nucleotide exchange factor (GEF) 11
 14858
 0.14
chr1_231113171_231113322 0.29 TTC13
 tetratricopeptide repeat domain 13
 1296
 0.3
chr14_20811572_20811723 0.29 RPPH1
 ribonuclease P RNA component H1
 81
 0.5
chr6_2222017_2222664 0.29 GMDS
 GDP-mannose 4,6-dehydratase
 23586
 0.28
chr16_1585013_1585440 0.29 TMEM204
 transmembrane protein 204
 1652
 0.19
chrX_153267742_153268222 0.29 IRAK1
 interleukin-1 receptor-associated kinase 1
 11715
 0.09
chr1_120642387_120642538 0.29 ENSG00000207149
 .
 27100
 0.19
chr21_45579276_45579734 0.28 AP001055.1
14075
 0.13
chr6_111180428_111180655 0.28 ENSG00000199360
 .
 2921
 0.21
chr19_22193781_22193932 0.28 ZNF208
 zinc finger protein 208
 105
 0.98
chr2_98279402_98280293 0.28 ACTR1B
 ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
 723
 0.38
chr1_89664664_89664873 0.28 GBP4
 guanylate binding protein 4
 153
 0.96
chr22_42831151_42831302 0.28 NFAM1
 NFAT activating protein with ITAM motif 1
 2825
 0.27
chr6_160241186_160241397 0.28 PNLDC1
 poly(A)-specific ribonuclease (PARN)-like domain containing 1
 19985
 0.12
chr8_24151584_24151953 0.28 ADAM28
 ADAM metallopeptidase domain 28
 144
 0.97
chr2_45168726_45169073 0.28 SIX3
 SIX homeobox 3
 3
 0.61
chr1_207997626_207997777 0.28 ENSG00000203709
 .
 21833
 0.22
chr17_72459271_72459541 0.28 CD300A
 CD300a molecule
 3149
 0.19
chr1_160614457_160614608 0.28 SLAMF1
 signaling lymphocytic activation molecule family member 1
 2279
 0.26
chr16_29611589_29612053 0.28 ENSG00000266758
 .
 1235
 0.4
chr6_90120799_90121205 0.28 RRAGD
 Ras-related GTP binding D
 787
 0.65
chr16_83760457_83760608 0.28 RP11-298D21.2
550
 0.74
chr16_89043094_89043288 0.28 CBFA2T3
 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
 210
 0.92
chr2_68966290_68966892 0.28 ARHGAP25
 Rho GTPase activating protein 25
 4577
 0.29
chr4_186706311_186706462 0.28 SORBS2
 sorbin and SH3 domain containing 2
 9320
 0.25
chr8_121744015_121744417 0.28 RP11-713M15.1
29277
 0.22
chr11_128595669_128596120 0.28 SENCR
 smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA
 29976
 0.16
chr9_66109751_66110085 0.28 ENSG00000202474
 .
 348344
 0.01
chr15_45005178_45005397 0.28 B2M
 beta-2-microglobulin
 1572
 0.31
chr2_197034753_197035766 0.27 STK17B
 serine/threonine kinase 17b
 465
 0.83
chr12_9948574_9948725 0.27 KLRF1
 killer cell lectin-like receptor subfamily F, member 1
 31428
 0.12
chr12_6570039_6570337 0.27 TAPBPL
 TAP binding protein-like
 8938
 0.09
chr19_21182444_21182737 0.27 ZNF430
 zinc finger protein 430
 20836
 0.19
chr10_26737911_26738372 0.27 APBB1IP
 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
 10787
 0.27
chr10_81947502_81948014 0.27 ANXA11
 annexin A11
 14981
 0.2
chr7_142180665_142180816 0.27 PRSS3P3
 protease, serine, 3 pseudogene 3
 191131
 0.02
chr4_99124752_99124919 0.27 ENSG00000200658
 .
 29900
 0.18

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.5 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.1 0.2 GO:0002540 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1 0.4 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.4 GO:1904035 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.1 0.4 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.1 0.3 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.2 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.2 GO:0019372 lipoxygenase pathway(GO:0019372)
0.1 0.2 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.1 0.5 GO:0045059 positive thymic T cell selection(GO:0045059)
0.1 0.2 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1 0.2 GO:0010815 bradykinin catabolic process(GO:0010815)
0.1 0.2 GO:1901419 regulation of response to alcohol(GO:1901419)
0.1 0.5 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.1 0.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.3 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.1 0.2 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.1 0.3 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.1 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.4 GO:0042832 defense response to protozoan(GO:0042832)
0.1 0.2 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.1 0.2 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 0.2 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.2 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0 0.1 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.2 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.0 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.1 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.2 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.0 0.1 GO:0048143 astrocyte activation(GO:0048143)
0.0 0.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.2 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.0 GO:0002691 regulation of cellular extravasation(GO:0002691)
0.0 0.4 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.2 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.2 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.3 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:0002830 positive regulation of type 2 immune response(GO:0002830)
0.0 0.2 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.5 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.0 GO:0090205 positive regulation of cholesterol metabolic process(GO:0090205)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.2 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.2 GO:0046033 AMP metabolic process(GO:0046033)
0.0 0.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.2 GO:0060263 regulation of respiratory burst(GO:0060263)
0.0 0.4 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.6 GO:0030101 natural killer cell activation(GO:0030101)
0.0 1.7 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.1 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.0 0.2 GO:0036230 granulocyte activation(GO:0036230)
0.0 0.1 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0071636 positive regulation of transforming growth factor beta production(GO:0071636)
0.0 0.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.2 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0046719 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.1 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0002478 antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0 0.6 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.0 0.1 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0 0.0 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.0 0.1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.4 GO:0045576 mast cell activation(GO:0045576)
0.0 0.1 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.2 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.3 GO:0009309 amine biosynthetic process(GO:0009309)
0.0 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.0 GO:0007343 egg activation(GO:0007343)
0.0 0.0 GO:0032621 interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0 0.1 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0045007 depurination(GO:0045007)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.2 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.0 0.2 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.0 GO:0046137 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.1 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.1 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.0 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.0 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.0 0.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.0 GO:0010310 regulation of hydrogen peroxide metabolic process(GO:0010310)
0.0 0.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.1 GO:0032747 interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0 0.0 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.1 GO:0050665 hydrogen peroxide biosynthetic process(GO:0050665)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.4 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0097191 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.0 0.0 GO:0048669 collateral sprouting in absence of injury(GO:0048669)
0.0 0.0 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.0 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.2 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.0 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.1 GO:0002286 T cell activation involved in immune response(GO:0002286)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.0 GO:0072131 kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0 0.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.0 GO:0014805 smooth muscle adaptation(GO:0014805)
0.0 0.0 GO:0014889 muscle atrophy(GO:0014889)
0.0 0.0 GO:0006222 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.1 GO:0006863 purine nucleobase transport(GO:0006863)
0.0 0.1 GO:0033151 V(D)J recombination(GO:0033151)
0.0 0.0 GO:0090382 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.0 GO:0014002 astrocyte development(GO:0014002)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.2 GO:0030903 notochord development(GO:0030903)
0.0 0.0 GO:0014742 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0 0.1 GO:0050655 dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.0 0.1 GO:0051547 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0 0.1 GO:1903077 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.0 GO:0042940 D-amino acid transport(GO:0042940)
0.0 0.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0010288 response to lead ion(GO:0010288)
0.0 0.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.0 GO:0060253 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) regulation of glial cell proliferation(GO:0060251) negative regulation of glial cell proliferation(GO:0060253)
0.0 0.0 GO:0072217 negative regulation of metanephros development(GO:0072217)
0.0 0.1 GO:0003057 regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0 0.0 GO:0032801 receptor catabolic process(GO:0032801)
0.0 0.1 GO:0072498 embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0 0.0 GO:0006681 galactosylceramide metabolic process(GO:0006681)
0.0 0.1 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 0.1 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.0 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.2 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.0 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0015669 gas transport(GO:0015669)
0.0 0.0 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.0 GO:0060437 lung growth(GO:0060437)
0.0 0.0 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.1 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.1 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.0 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.0 GO:2000644 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0 0.0 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.0 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.0 0.0 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0 0.3 GO:0032480 negative regulation of type I interferon production(GO:0032480)
0.0 0.0 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.0 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0045022 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.0 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.0 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0042088 T-helper 1 type immune response(GO:0042088)
0.0 0.0 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.0 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.0 0.0 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.0 GO:0010988 regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0 0.1 GO:0000085 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.2 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.5 GO:0000346 transcription export complex(GO:0000346)
0.1 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.2 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 0.4 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.1 0.2 GO:0000124 SAGA complex(GO:0000124)
0.1 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0033011 perinuclear theca(GO:0033011)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.3 GO:0046930 pore complex(GO:0046930)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.1 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.6 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.1 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.9 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.0 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.0 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.0 GO:0032009 early phagosome(GO:0032009)
0.0 0.0 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.0 GO:0001740 Barr body(GO:0001740)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.3 GO:1901567 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.1 0.6 GO:0005522 profilin binding(GO:0005522)
0.1 0.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.4 GO:0001727 lipid kinase activity(GO:0001727)
0.1 0.2 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 0.3 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 0.2 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.1 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.2 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 0.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 1.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.2 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.3 GO:0015288 porin activity(GO:0015288)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.2 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697)
0.0 1.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.3 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.1 GO:0004476 mannose-6-phosphate isomerase activity(GO:0004476)
0.0 0.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.8 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.1 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.2 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.1 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.0 GO:0032558 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.0 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.1 GO:0070402 NADPH binding(GO:0070402)
0.0 0.1 GO:0003701 obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.3 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.0 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.0 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.0 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.0 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.3 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.0 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.0 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.0 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345)
0.0 0.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.0 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.0 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.0 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.0 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.0 0.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.0 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.0 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.0 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.0 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.0 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.0 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.0 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.0 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.0 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.0 GO:0016803 ether hydrolase activity(GO:0016803)
0.0 0.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0051766 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.0 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.2 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.5 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.1 PID EPO PATHWAY EPO signaling pathway
0.0 0.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.2 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.1 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.2 PID CERAMIDE PATHWAY Ceramide signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 2.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.0 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.0 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.8 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.9 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.4 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.2 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.0 0.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.0 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.2 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.0 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.1 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.1 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.0 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.2 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.1 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.1 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.0 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.0 REACTOME SHC RELATED EVENTS Genes involved in SHC-related events
0.0 0.1 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing