Project
ENCODE: H3K4me3 ChIP-Seq of primary human cells
Navigation
Downloads
Logo

Results for PDX1

Z-value: 0.76

Motif logo

logo of

Transcription factors associated with PDX1

Gene Symbol Gene ID Gene Info
PDX1
ENSG00000139515.5 pancreatic and duodenal homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr13_28494142_28494415PDX11210.934648-0.531.4e-01Click!
chr13_28491022_28491173PDX130600.2011090.501.7e-01Click!
chr13_28493957_28494140PDX11090.944493-0.412.8e-01Click!
chr13_28493585_28493736PDX14970.716519-0.176.6e-01Click!

Activity of the PDX1 motif across conditions

Conditions sorted by the z-value of the PDX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_106239153_106239583 0.44 RP11-680E19.1
104326
 0.08
chr7_93550787_93551002 0.38 GNG11
 guanine nucleotide binding protein (G protein), gamma 11
 117
 0.96
chr12_78336292_78336638 0.33 NAV3
 neuron navigator 3
 23591
 0.28
chr16_54968513_54968925 0.32 IRX5
 iroquois homeobox 5
 2735
 0.43
chr12_49661445_49661747 0.32 TUBA1C
 tubulin, alpha 1c
 2732
 0.15
chr7_90012947_90013805 0.31 CLDN12
 claudin 12
 341
 0.9
chr6_56715748_56715936 0.31 DST
 dystonin
 907
 0.63
chr12_56917781_56918152 0.30 RBMS2
 RNA binding motif, single stranded interacting protein 2
 2183
 0.23
chr16_89990965_89991193 0.30 TUBB3
 Tubulin beta-3 chain
 1305
 0.26
chr10_33620428_33620906 0.29 NRP1
 neuropilin 1
 2643
 0.37
chr15_96878465_96878729 0.29 ENSG00000222651
 .
 2107
 0.24
chr8_42398666_42399077 0.28 SLC20A2
 solute carrier family 20 (phosphate transporter), member 2
 1802
 0.28
chr1_196577911_196578299 0.28 KCNT2
 potassium channel, subfamily T, member 2
 250
 0.94
chr21_17442999_17443232 0.27 ENSG00000252273
 .
 35286
 0.24
chr13_24146066_24146217 0.27 TNFRSF19
 tumor necrosis factor receptor superfamily, member 19
 1338
 0.59
chr10_6763782_6764322 0.27 PRKCQ
 protein kinase C, theta
 141789
 0.05
chr3_150089259_150089633 0.27 TSC22D2
 TSC22 domain family, member 2
 36676
 0.21
chr15_96878987_96879612 0.26 ENSG00000222651
 .
 2809
 0.21
chr17_2117226_2117470 0.26 SMG6
 SMG6 nonsense mediated mRNA decay factor
 295
 0.52
chr7_95107815_95108198 0.25 ASB4
 ankyrin repeat and SOCS box containing 4
 7207
 0.2
chr1_151964634_151965021 0.25 S100A10
 S100 calcium binding protein A10
 227
 0.9
chr13_95619763_95620412 0.25 ENSG00000252335
 .
 51402
 0.18
chr10_29010683_29010909 0.25 ENSG00000201001
 .
 38936
 0.14
chr3_112356169_112356393 0.25 CCDC80
 coiled-coil domain containing 80
 663
 0.77
chr22_36232810_36232961 0.24 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 3380
 0.35
chr11_65324098_65324348 0.24 LTBP3
 latent transforming growth factor beta binding protein 3
 1013
 0.31
chr10_119303944_119304573 0.24 EMX2OS
 EMX2 opposite strand/antisense RNA
 321
 0.88
chr3_87036535_87037613 0.23 VGLL3
 vestigial like 3 (Drosophila)
 2778
 0.42
chr4_41215270_41215769 0.23 APBB2
 amyloid beta (A4) precursor protein-binding, family B, member 2
 956
 0.59
chr4_95917210_95917447 0.23 BMPR1B
 bone morphogenetic protein receptor, type IB
 55
 0.99
chr5_148786412_148786563 0.23 ENSG00000208035
 .
 21994
 0.11
chr8_41165312_41165463 0.23 SFRP1
 secreted frizzled-related protein 1
 878
 0.57
chr11_126456116_126456330 0.23 KIRREL3-AS1
 KIRREL3 antisense RNA 1
 42381
 0.16
chr3_115342492_115342792 0.23 GAP43
 growth associated protein 43
 285
 0.94
chr11_31830603_31830754 0.23 PAX6
 paired box 6
 1175
 0.49
chr2_200446222_200446758 0.23 SATB2
 SATB homeobox 2
 110501
 0.07
chr5_3597777_3597928 0.23 IRX1
 iroquois homeobox 1
 1684
 0.41
chr18_25754335_25754486 0.22 CDH2
 cadherin 2, type 1, N-cadherin (neuronal)
 3000
 0.42
chr17_70113469_70114161 0.22 SOX9
 SRY (sex determining region Y)-box 9
 3346
 0.37
chr10_33621519_33621932 0.22 NRP1
 neuropilin 1
 1585
 0.49
chr11_121966638_121966789 0.22 ENSG00000207971
 .
 3839
 0.19
chr9_94710782_94711296 0.22 ROR2
 receptor tyrosine kinase-like orphan receptor 2
 123
 0.98
chr10_33622034_33622426 0.22 NRP1
 neuropilin 1
 1080
 0.63
chr2_203244162_203244384 0.22 BMPR2
 bone morphogenetic protein receptor, type II (serine/threonine kinase)
 2116
 0.28
chr20_36040358_36040543 0.22 SRC
 v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
 27897
 0.21
chr14_74300817_74300968 0.22 PTGR2
 prostaglandin reductase 2
 17655
 0.1
chr6_130686119_130686489 0.21 SAMD3
 sterile alpha motif domain containing 3
 266
 0.75
chr15_96881380_96881711 0.21 ENSG00000222651
 .
 5055
 0.17
chr15_60388257_60388408 0.21 FOXB1
 forkhead box B1
 91911
 0.09
chr13_84456002_84456225 0.21 SLITRK1
 SLIT and NTRK-like family, member 1
 415
 0.92
chr5_16713576_16713796 0.21 MYO10
 myosin X
 24810
 0.21
chr4_169553357_169553551 0.21 PALLD
 palladin, cytoskeletal associated protein
 686
 0.73
chr2_216283171_216283492 0.21 FN1
 fibronectin 1
 17459
 0.2
chr7_94025506_94025990 0.20 COL1A2
 collagen, type I, alpha 2
 1875
 0.46
chr14_52247052_52247252 0.20 RP11-280K24.4
15158
 0.18
chr11_24518160_24518510 0.20 LUZP2
 leucine zipper protein 2
 389
 0.91
chr13_95003800_95004010 0.20 ENSG00000212057
 .
 113739
 0.06
chr16_69854762_69854918 0.20 WWP2
 WW domain containing E3 ubiquitin protein ligase 2
 17800
 0.14
chr3_120215962_120216316 0.20 FSTL1
 follistatin-like 1
 46039
 0.16
chr7_98029134_98029377 0.20 BAIAP2L1
 BAI1-associated protein 2-like 1
 1125
 0.59
chr5_71406834_71406985 0.20 MAP1B
 microtubule-associated protein 1B
 3596
 0.33
chr14_36409550_36409712 0.20 RP11-116N8.1
42443
 0.16
chr8_42063953_42065062 0.20 PLAT
 plasminogen activator, tissue
 576
 0.71
chr8_42358808_42359006 0.20 SLC20A2
 solute carrier family 20 (phosphate transporter), member 2
 71
 0.97
chr7_80546522_80546706 0.19 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 1885
 0.51
chr11_31831142_31831293 0.19 PAX6
 paired box 6
 636
 0.72
chr7_129933276_129933885 0.19 CPA4
 carboxypeptidase A4
 461
 0.76
chrX_102585134_102585599 0.19 TCEAL7
 transcription elongation factor A (SII)-like 7
 209
 0.92
chr7_100777700_100777901 0.19 SERPINE1
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 7421
 0.1
chr11_122311916_122312418 0.19 ENSG00000252776
 .
 7751
 0.23
chr12_59311566_59311750 0.19 LRIG3
 leucine-rich repeats and immunoglobulin-like domains 3
 1669
 0.41
chr4_81191052_81191243 0.19 FGF5
 fibroblast growth factor 5
 3354
 0.31
chr11_12697523_12698245 0.19 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
 834
 0.75
chr3_44063258_44064101 0.18 ENSG00000252980
 .
 48900
 0.17
chr10_29228474_29228881 0.18 ENSG00000199402
 .
 65241
 0.13
chr4_71997150_71997347 0.18 SLC4A4
 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
 55755
 0.16
chr1_164529940_164530511 0.18 PBX1
 pre-B-cell leukemia homeobox 1
 1165
 0.61
chr9_100069620_100070257 0.18 CCDC180
 coiled-coil domain containing 180
 3
 0.98
chr7_116660690_116660934 0.18 ST7
 suppression of tumorigenicity 7
 481
 0.81
chr9_133722351_133722531 0.18 ABL1
 c-abl oncogene 1, non-receptor tyrosine kinase
 11988
 0.21
chr8_22023419_22024083 0.18 BMP1
 bone morphogenetic protein 1
 951
 0.4
chr18_53069042_53069242 0.18 TCF4
 transcription factor 4
 60
 0.98
chr7_110732102_110732377 0.18 LRRN3
 leucine rich repeat neuronal 3
 1140
 0.59
chr20_10844541_10844810 0.18 RP11-103J8.1
38257
 0.22
chr9_101014697_101014848 0.18 TBC1D2
 TBC1 domain family, member 2
 3090
 0.33
chr18_30310087_30311054 0.18 AC012123.1
 Uncharacterized protein
 39188
 0.17
chr13_61987939_61988245 0.18 PCDH20
 protocadherin 20
 1563
 0.57
chr3_110791913_110792064 0.18 PVRL3
 poliovirus receptor-related 3
 973
 0.53
chr5_92921648_92921875 0.18 ENSG00000237187
 .
 407
 0.85
chr16_17931379_17931530 0.17 XYLT1
 xylosyltransferase I
 366716
 0.01
chr10_102761690_102761841 0.17 LZTS2
 leucine zipper, putative tumor suppressor 2
 2155
 0.16
chr2_98962646_98962882 0.17 CNGA3
 cyclic nucleotide gated channel alpha 3
 113
 0.9
chrX_86773476_86773748 0.17 KLHL4
 kelch-like family member 4
 795
 0.74
chr15_37402857_37403086 0.17 MEIS2
 Meis homeobox 2
 9467
 0.23
chr12_91575190_91575391 0.17 DCN
 decorin
 537
 0.85
chr1_30179791_30179986 0.17 ENSG00000221126
 .
 62363
 0.15
chr13_27927443_27927612 0.17 ENSG00000252247
 .
 9644
 0.16
chr14_50996670_50996889 0.17 MAP4K5
 mitogen-activated protein kinase kinase kinase kinase 5
 2411
 0.26
chr6_116833589_116833880 0.17 TRAPPC3L
 trafficking protein particle complex 3-like
 228
 0.83
chr4_15471989_15472140 0.17 CC2D2A
 coiled-coil and C2 domain containing 2A
 427
 0.85
chr5_140864017_140864278 0.17 PCDHGC4
 protocadherin gamma subfamily C, 4
 594
 0.53
chr12_72724242_72724393 0.17 ENSG00000236333
 .
 55630
 0.15
chr15_63673071_63673237 0.17 CA12
 carbonic anhydrase XII
 880
 0.7
chr14_54687357_54687695 0.17 CDKN3
 cyclin-dependent kinase inhibitor 3
 176147
 0.03
chr10_49734913_49735076 0.17 ARHGAP22
 Rho GTPase activating protein 22
 2713
 0.31
chr6_116834038_116834189 0.17 TRAPPC3L
 trafficking protein particle complex 3-like
 607
 0.55
chr16_2315946_2316097 0.16 RNPS1
 RNA binding protein S1, serine-rich domain
 503
 0.49
chr9_69882113_69882264 0.16 ENSG00000206804
 .
 10705
 0.26
chr5_15620950_15621349 0.16 FBXL7
 F-box and leucine-rich repeat protein 7
 5058
 0.28
chr1_30559030_30559253 0.16 ENSG00000222787
 .
 201392
 0.03
chr8_33457544_33457712 0.16 DUSP26
 dual specificity phosphatase 26 (putative)
 4
 0.98
chr14_52822199_52822380 0.16 PTGER2
 prostaglandin E receptor 2 (subtype EP2), 53kDa
 41176
 0.18
chr6_82600909_82601087 0.16 ENSG00000206886
 .
 127257
 0.05
chr12_105651079_105651410 0.16 APPL2
 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
 21228
 0.19
chr22_18640512_18640663 0.16 USP18
 ubiquitin specific peptidase 18
 7921
 0.17
chr16_69959859_69960167 0.16 WWP2
 WW domain containing E3 ubiquitin protein ligase 2
 1120
 0.44
chr4_186853985_186854481 0.16 ENSG00000239034
 .
 13004
 0.21
chr9_18474095_18474958 0.16 ADAMTSL1
 ADAMTS-like 1
 295
 0.95
chr5_87780535_87780686 0.16 TMEM161B-AS1
 TMEM161B antisense RNA 1
 58098
 0.14
chr3_159483781_159484285 0.16 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 1141
 0.44
chr5_3197978_3198129 0.16 IRX1
 iroquois homeobox 1
 398115
 0.01
chr7_55142263_55142544 0.16 EGFR
 epidermal growth factor receptor
 35013
 0.22
chr21_17792302_17792515 0.16 ENSG00000207638
 .
 119001
 0.06
chr12_30906652_30906803 0.16 CAPRIN2
 caprin family member 2
 518
 0.86
chr4_95635906_95636061 0.16 BMPR1B
 bone morphogenetic protein receptor, type IB
 43136
 0.21
chr2_317550_317840 0.16 FAM150B
 family with sequence similarity 150, member B
 28844
 0.16
chr10_33630285_33630504 0.16 NRP1
 neuropilin 1
 5204
 0.3
chr12_120246427_120246712 0.16 CIT
 citron (rho-interacting, serine/threonine kinase 21)
 5382
 0.27
chr2_192416956_192417327 0.16 NABP1
 nucleic acid binding protein 1
 125721
 0.05
chr10_26846446_26846738 0.16 ENSG00000199733
 .
 48074
 0.17
chr11_19585849_19586032 0.15 ENSG00000265210
 .
 10917
 0.19
chr15_77710885_77711123 0.15 PEAK1
 pseudopodium-enriched atypical kinase 1
 1438
 0.39
chr17_48124761_48124984 0.15 ITGA3
 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
 8467
 0.14
chr7_151297260_151297484 0.15 PRKAG2
 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
 32067
 0.18
chr6_19691587_19692480 0.15 ENSG00000200957
 .
 49273
 0.18
chr14_53416976_53417370 0.15 FERMT2
 fermitin family member 2
 113
 0.98
chr11_8290078_8290567 0.15 LMO1
 LIM domain only 1 (rhombotin 1)
 59
 0.98
chr17_2151727_2151878 0.15 SMG6
 SMG6 nonsense mediated mRNA decay factor
 3596
 0.15
chr9_66699115_66699266 0.15 ENSG00000206946
 .
 13544
 0.3
chr10_25008347_25008498 0.15 ARHGAP21
 Rho GTPase activating protein 21
 2373
 0.41
chr6_37105124_37105275 0.15 PIM1
 pim-1 oncogene
 32780
 0.15
chr9_21555895_21556299 0.15 MIR31HG
 MIR31 host gene (non-protein coding)
 3571
 0.22
chr10_112296305_112296649 0.15 SMC3
 structural maintenance of chromosomes 3
 30972
 0.13
chr4_126311194_126311396 0.15 FAT4
 FAT atypical cadherin 4
 3796
 0.32
chr1_78474827_78475270 0.15 DNAJB4
 DnaJ (Hsp40) homolog, subfamily B, member 4
 4510
 0.17
chr6_140859694_140859893 0.15 ENSG00000221336
 .
 122057
 0.06
chr4_81192022_81192173 0.15 FGF5
 fibroblast growth factor 5
 4304
 0.29
chr1_52456055_52456657 0.15 RAB3B
 RAB3B, member RAS oncogene family
 80
 0.95
chr8_56901426_56901577 0.15 ENSG00000240905
 .
 8405
 0.16
chr7_134465735_134465936 0.15 CALD1
 caldesmon 1
 1406
 0.57
chr10_18453155_18453355 0.14 CACNB2
 calcium channel, voltage-dependent, beta 2 subunit
 23146
 0.25
chr3_111717643_111718087 0.14 TAGLN3
 transgelin 3
 171
 0.95
chr1_39877379_39877579 0.14 KIAA0754
 KIAA0754
 1328
 0.41
chr8_38855409_38855789 0.14 ADAM9
 ADAM metallopeptidase domain 9
 1094
 0.34
chr5_3560421_3560572 0.14 IRX1
 iroquois homeobox 1
 35672
 0.2
chr2_238318512_238318719 0.14 COL6A3
 collagen, type VI, alpha 3
 4176
 0.24
chr4_4576417_4576570 0.14 STX18-AS1
 STX18 antisense RNA 1 (head to head)
 32348
 0.18
chr15_39985088_39985239 0.14 RP11-37C7.3
89609
 0.07
chr15_52675291_52675442 0.14 MYO5A
 myosin VA (heavy chain 12, myoxin)
 31688
 0.19
chr1_170639404_170639633 0.14 PRRX1
 paired related homeobox 1
 6440
 0.31
chr5_58883529_58883730 0.14 PDE4D
 phosphodiesterase 4D, cAMP-specific
 1304
 0.62
chr15_96886136_96886425 0.14 ENSG00000222651
 .
 9790
 0.16
chr6_99796840_99797257 0.14 FAXC
 failed axon connections homolog (Drosophila)
 483
 0.83
chr1_215178346_215178497 0.14 KCNK2
 potassium channel, subfamily K, member 2
 777
 0.8
chr1_85873190_85873383 0.14 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 3106
 0.28
chr8_6456469_6456620 0.14 ANGPT2
 angiopoietin 2
 35614
 0.18
chr2_239337309_239337646 0.14 AC016999.2
1107
 0.42
chr2_202929676_202929827 0.14 AC079354.1
 uncharacterized protein KIAA2012
 8227
 0.16
chr7_129934048_129934199 0.14 CPA4
 carboxypeptidase A4
 1004
 0.45
chr3_61546098_61546562 0.14 PTPRG
 protein tyrosine phosphatase, receptor type, G
 1255
 0.64
chr3_105657205_105657471 0.14 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
 68942
 0.15
chr7_18549207_18549425 0.14 HDAC9
 histone deacetylase 9
 380
 0.92
chr10_128250315_128250594 0.14 ENSG00000221717
 .
 4821
 0.29
chr19_15361458_15361910 0.14 EPHX3
 epoxide hydrolase 3
 17438
 0.15
chr5_155409653_155409804 0.14 SGCD
 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
 112374
 0.07
chr6_9116214_9116470 0.14 SLC35B3
 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
 680548
 0.0
chr10_116474996_116475239 0.14 ABLIM1
 actin binding LIM protein 1
 30703
 0.21
chr12_79916269_79916420 0.14 ENSG00000243714
 .
 2606
 0.3
chr11_33399282_33399433 0.14 ENSG00000223134
 .
 23346
 0.23
chr5_171986318_171986532 0.14 AC027309.1
50011
 0.13
chr3_55521292_55522040 0.14 WNT5A-AS1
 WNT5A antisense RNA 1
 61
 0.83
chr4_87373379_87373575 0.13 MAPK10
 mitogen-activated protein kinase 10
 806
 0.74
chr19_1361544_1361801 0.13 MUM1
 melanoma associated antigen (mutated) 1
 5309
 0.1
chr10_119302142_119302346 0.13 EMX2
 empty spiracles homeobox 2
 265
 0.64
chr5_110252790_110252941 0.13 TSLP
 thymic stromal lymphopoietin
 152895
 0.04
chr7_130589596_130590032 0.13 ENSG00000226380
 .
 27516
 0.22
chr8_87188438_87188625 0.13 CTD-3118D11.3
4116
 0.24
chr1_182932139_182932350 0.13 ENSG00000264768
 .
 3534
 0.19
chr14_33776607_33776786 0.13 NPAS3
 neuronal PAS domain protein 3
 92178
 0.1
chr15_86162614_86163207 0.13 RP11-815J21.3
8010
 0.15
chr10_92679511_92679800 0.13 ANKRD1
 ankyrin repeat domain 1 (cardiac muscle)
 1378
 0.39
chr15_71054590_71054766 0.13 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 1091
 0.55
chr1_86079084_86079255 0.13 ENSG00000199934
 .
 21206
 0.18
chr11_126506918_126507382 0.13 RP11-115C10.1
15597
 0.26
chr9_18472965_18473116 0.13 ADAMTSL1
 ADAMTS-like 1
 852
 0.75
chr9_91791007_91791172 0.13 SHC3
 SHC (Src homology 2 domain containing) transforming protein 3
 2593
 0.36
chr5_2750019_2750705 0.13 IRX2
 iroquois homeobox 2
 1407
 0.43
chr10_102761020_102761171 0.13 LZTS2
 leucine zipper, putative tumor suppressor 2
 1485
 0.23
chr3_99989145_99989333 0.13 TBC1D23
 TBC1 domain family, member 23
 3203
 0.26
chr7_126848587_126848738 0.13 AC000099.1
6519
 0.26

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.3 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.3 GO:0022605 oogenesis stage(GO:0022605)
0.1 0.2 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.1 0.2 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.2 GO:0071504 cellular response to heparin(GO:0071504)
0.1 0.2 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.1 0.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.1 0.3 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.1 0.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 0.2 GO:0060013 righting reflex(GO:0060013)
0.1 0.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.2 GO:0009158 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.1 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.3 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.0 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.1 GO:0060676 ureteric bud formation(GO:0060676)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.0 GO:0033622 integrin activation(GO:0033622)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.0 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0048875 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.0 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.1 GO:0048343 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0 0.1 GO:0071694 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.0 GO:0060916 mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0 0.0 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.0 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.3 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.0 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.1 GO:0060174 limb bud formation(GO:0060174)
0.0 0.0 GO:0051014 actin filament severing(GO:0051014)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.0 GO:0061430 bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0 0.1 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.0 GO:0032060 bleb assembly(GO:0032060)
0.0 0.0 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.0 GO:1903053 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.0 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.2 GO:0098743 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.0 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.1 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.0 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.0 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.0 GO:0048808 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.0 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.0 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.0 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.0 0.0 GO:0051665 membrane raft localization(GO:0051665)
0.0 0.0 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.3 GO:0051101 regulation of DNA binding(GO:0051101)
0.0 0.1 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.3 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.0 GO:0009215 purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0 0.4 GO:0071377 cellular response to glucagon stimulus(GO:0071377)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.0 GO:0030426 growth cone(GO:0030426)
0.0 0.0 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.3 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.3 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.3 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.4 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.0 GO:0034711 inhibin binding(GO:0034711)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.3 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.1 GO:0070628 proteasome binding(GO:0070628)
0.0 0.0 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.0 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.0 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)
0.0 0.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.0 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.0 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.1 GO:0005523 tropomyosin binding(GO:0005523)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.0 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 PID BMP PATHWAY BMP receptor signaling
0.0 0.1 PID VEGFR1 PATHWAY VEGFR1 specific signals

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.1 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.0 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.0 REACTOME NEURONAL SYSTEM Genes involved in Neuronal System
0.0 0.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen