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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PDX1

Z-value: 0.76

Motif logo

Transcription factors associated with PDX1

Gene Symbol	Gene ID	Gene Info
PDX1 Ensembl NCBI GeneCards UniProt	ENSG00000139515.5	PDX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PDX1	chr13_28494142_28494415	121	0.934648	-0.53	1.4e-01	Click!
PDX1	chr13_28491022_28491173	3060	0.201109	0.50	1.7e-01	Click!
PDX1	chr13_28493957_28494140	109	0.944493	-0.41	2.8e-01	Click!
PDX1	chr13_28493585_28493736	497	0.716519	-0.17	6.6e-01	Click!

Activity of the PDX1 motif across conditions

Conditions sorted by the z-value of the PDX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_106239153_106239583	0.44	RP11-680E19.1		104326	0.08
chr7_93550787_93551002	0.38	GNG11	guanine nucleotide binding protein (G protein), gamma 11	117	0.96
chr12_78336292_78336638	0.33	NAV3	neuron navigator 3	23591	0.28
chr16_54968513_54968925	0.32	IRX5	iroquois homeobox 5	2735	0.43
chr12_49661445_49661747	0.32	TUBA1C	tubulin, alpha 1c	2732	0.15
chr7_90012947_90013805	0.31	CLDN12	claudin 12	341	0.9
chr6_56715748_56715936	0.31	DST	dystonin	907	0.63
chr12_56917781_56918152	0.30	RBMS2	RNA binding motif, single stranded interacting protein 2	2183	0.23
chr16_89990965_89991193	0.30	TUBB3	Tubulin beta-3 chain	1305	0.26
chr10_33620428_33620906	0.29	NRP1	neuropilin 1	2643	0.37
chr15_96878465_96878729	0.29	ENSG00000222651	.	2107	0.24
chr8_42398666_42399077	0.28	SLC20A2	solute carrier family 20 (phosphate transporter), member 2	1802	0.28
chr1_196577911_196578299	0.28	KCNT2	potassium channel, subfamily T, member 2	250	0.94
chr21_17442999_17443232	0.27	ENSG00000252273	.	35286	0.24
chr13_24146066_24146217	0.27	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	1338	0.59
chr10_6763782_6764322	0.27	PRKCQ	protein kinase C, theta	141789	0.05
chr3_150089259_150089633	0.27	TSC22D2	TSC22 domain family, member 2	36676	0.21
chr15_96878987_96879612	0.26	ENSG00000222651	.	2809	0.21
chr17_2117226_2117470	0.26	SMG6	SMG6 nonsense mediated mRNA decay factor	295	0.52
chr7_95107815_95108198	0.25	ASB4	ankyrin repeat and SOCS box containing 4	7207	0.2
chr1_151964634_151965021	0.25	S100A10	S100 calcium binding protein A10	227	0.9
chr13_95619763_95620412	0.25	ENSG00000252335	.	51402	0.18
chr10_29010683_29010909	0.25	ENSG00000201001	.	38936	0.14
chr3_112356169_112356393	0.25	CCDC80	coiled-coil domain containing 80	663	0.77
chr22_36232810_36232961	0.24	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	3380	0.35
chr11_65324098_65324348	0.24	LTBP3	latent transforming growth factor beta binding protein 3	1013	0.31
chr10_119303944_119304573	0.24	EMX2OS	EMX2 opposite strand/antisense RNA	321	0.88
chr3_87036535_87037613	0.23	VGLL3	vestigial like 3 (Drosophila)	2778	0.42
chr4_41215270_41215769	0.23	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	956	0.59
chr4_95917210_95917447	0.23	BMPR1B	bone morphogenetic protein receptor, type IB	55	0.99
chr5_148786412_148786563	0.23	ENSG00000208035	.	21994	0.11
chr8_41165312_41165463	0.23	SFRP1	secreted frizzled-related protein 1	878	0.57
chr11_126456116_126456330	0.23	KIRREL3-AS1	KIRREL3 antisense RNA 1	42381	0.16
chr3_115342492_115342792	0.23	GAP43	growth associated protein 43	285	0.94
chr11_31830603_31830754	0.23	PAX6	paired box 6	1175	0.49
chr2_200446222_200446758	0.23	SATB2	SATB homeobox 2	110501	0.07
chr5_3597777_3597928	0.23	IRX1	iroquois homeobox 1	1684	0.41
chr18_25754335_25754486	0.22	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	3000	0.42
chr17_70113469_70114161	0.22	SOX9	SRY (sex determining region Y)-box 9	3346	0.37
chr10_33621519_33621932	0.22	NRP1	neuropilin 1	1585	0.49
chr11_121966638_121966789	0.22	ENSG00000207971	.	3839	0.19
chr9_94710782_94711296	0.22	ROR2	receptor tyrosine kinase-like orphan receptor 2	123	0.98
chr10_33622034_33622426	0.22	NRP1	neuropilin 1	1080	0.63
chr2_203244162_203244384	0.22	BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	2116	0.28
chr20_36040358_36040543	0.22	SRC	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	27897	0.21
chr14_74300817_74300968	0.22	PTGR2	prostaglandin reductase 2	17655	0.1
chr6_130686119_130686489	0.21	SAMD3	sterile alpha motif domain containing 3	266	0.75
chr15_96881380_96881711	0.21	ENSG00000222651	.	5055	0.17
chr15_60388257_60388408	0.21	FOXB1	forkhead box B1	91911	0.09
chr13_84456002_84456225	0.21	SLITRK1	SLIT and NTRK-like family, member 1	415	0.92
chr5_16713576_16713796	0.21	MYO10	myosin X	24810	0.21
chr4_169553357_169553551	0.21	PALLD	palladin, cytoskeletal associated protein	686	0.73
chr2_216283171_216283492	0.21	FN1	fibronectin 1	17459	0.2
chr7_94025506_94025990	0.20	COL1A2	collagen, type I, alpha 2	1875	0.46
chr14_52247052_52247252	0.20	RP11-280K24.4		15158	0.18
chr11_24518160_24518510	0.20	LUZP2	leucine zipper protein 2	389	0.91
chr13_95003800_95004010	0.20	ENSG00000212057	.	113739	0.06
chr16_69854762_69854918	0.20	WWP2	WW domain containing E3 ubiquitin protein ligase 2	17800	0.14
chr3_120215962_120216316	0.20	FSTL1	follistatin-like 1	46039	0.16
chr7_98029134_98029377	0.20	BAIAP2L1	BAI1-associated protein 2-like 1	1125	0.59
chr5_71406834_71406985	0.20	MAP1B	microtubule-associated protein 1B	3596	0.33
chr14_36409550_36409712	0.20	RP11-116N8.1		42443	0.16
chr8_42063953_42065062	0.20	PLAT	plasminogen activator, tissue	576	0.71
chr8_42358808_42359006	0.20	SLC20A2	solute carrier family 20 (phosphate transporter), member 2	71	0.97
chr7_80546522_80546706	0.19	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	1885	0.51
chr11_31831142_31831293	0.19	PAX6	paired box 6	636	0.72
chr7_129933276_129933885	0.19	CPA4	carboxypeptidase A4	461	0.76
chrX_102585134_102585599	0.19	TCEAL7	transcription elongation factor A (SII)-like 7	209	0.92
chr7_100777700_100777901	0.19	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	7421	0.1
chr11_122311916_122312418	0.19	ENSG00000252776	.	7751	0.23
chr12_59311566_59311750	0.19	LRIG3	leucine-rich repeats and immunoglobulin-like domains 3	1669	0.41
chr4_81191052_81191243	0.19	FGF5	fibroblast growth factor 5	3354	0.31
chr11_12697523_12698245	0.19	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	834	0.75
chr3_44063258_44064101	0.18	ENSG00000252980	.	48900	0.17
chr10_29228474_29228881	0.18	ENSG00000199402	.	65241	0.13
chr4_71997150_71997347	0.18	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	55755	0.16
chr1_164529940_164530511	0.18	PBX1	pre-B-cell leukemia homeobox 1	1165	0.61
chr9_100069620_100070257	0.18	CCDC180	coiled-coil domain containing 180	3	0.98
chr7_116660690_116660934	0.18	ST7	suppression of tumorigenicity 7	481	0.81
chr9_133722351_133722531	0.18	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	11988	0.21
chr8_22023419_22024083	0.18	BMP1	bone morphogenetic protein 1	951	0.4
chr18_53069042_53069242	0.18	TCF4	transcription factor 4	60	0.98
chr7_110732102_110732377	0.18	LRRN3	leucine rich repeat neuronal 3	1140	0.59
chr20_10844541_10844810	0.18	RP11-103J8.1		38257	0.22
chr9_101014697_101014848	0.18	TBC1D2	TBC1 domain family, member 2	3090	0.33
chr18_30310087_30311054	0.18	AC012123.1	Uncharacterized protein	39188	0.17
chr13_61987939_61988245	0.18	PCDH20	protocadherin 20	1563	0.57
chr3_110791913_110792064	0.18	PVRL3	poliovirus receptor-related 3	973	0.53
chr5_92921648_92921875	0.18	ENSG00000237187	.	407	0.85
chr16_17931379_17931530	0.17	XYLT1	xylosyltransferase I	366716	0.01
chr10_102761690_102761841	0.17	LZTS2	leucine zipper, putative tumor suppressor 2	2155	0.16
chr2_98962646_98962882	0.17	CNGA3	cyclic nucleotide gated channel alpha 3	113	0.9
chrX_86773476_86773748	0.17	KLHL4	kelch-like family member 4	795	0.74
chr15_37402857_37403086	0.17	MEIS2	Meis homeobox 2	9467	0.23
chr12_91575190_91575391	0.17	DCN	decorin	537	0.85
chr1_30179791_30179986	0.17	ENSG00000221126	.	62363	0.15
chr13_27927443_27927612	0.17	ENSG00000252247	.	9644	0.16
chr14_50996670_50996889	0.17	MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5	2411	0.26
chr6_116833589_116833880	0.17	TRAPPC3L	trafficking protein particle complex 3-like	228	0.83
chr4_15471989_15472140	0.17	CC2D2A	coiled-coil and C2 domain containing 2A	427	0.85
chr5_140864017_140864278	0.17	PCDHGC4	protocadherin gamma subfamily C, 4	594	0.53
chr12_72724242_72724393	0.17	ENSG00000236333	.	55630	0.15
chr15_63673071_63673237	0.17	CA12	carbonic anhydrase XII	880	0.7
chr14_54687357_54687695	0.17	CDKN3	cyclin-dependent kinase inhibitor 3	176147	0.03
chr10_49734913_49735076	0.17	ARHGAP22	Rho GTPase activating protein 22	2713	0.31
chr6_116834038_116834189	0.17	TRAPPC3L	trafficking protein particle complex 3-like	607	0.55
chr16_2315946_2316097	0.16	RNPS1	RNA binding protein S1, serine-rich domain	503	0.49
chr9_69882113_69882264	0.16	ENSG00000206804	.	10705	0.26
chr5_15620950_15621349	0.16	FBXL7	F-box and leucine-rich repeat protein 7	5058	0.28
chr1_30559030_30559253	0.16	ENSG00000222787	.	201392	0.03
chr8_33457544_33457712	0.16	DUSP26	dual specificity phosphatase 26 (putative)	4	0.98
chr14_52822199_52822380	0.16	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	41176	0.18
chr6_82600909_82601087	0.16	ENSG00000206886	.	127257	0.05
chr12_105651079_105651410	0.16	APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	21228	0.19
chr22_18640512_18640663	0.16	USP18	ubiquitin specific peptidase 18	7921	0.17
chr16_69959859_69960167	0.16	WWP2	WW domain containing E3 ubiquitin protein ligase 2	1120	0.44
chr4_186853985_186854481	0.16	ENSG00000239034	.	13004	0.21
chr9_18474095_18474958	0.16	ADAMTSL1	ADAMTS-like 1	295	0.95
chr5_87780535_87780686	0.16	TMEM161B-AS1	TMEM161B antisense RNA 1	58098	0.14
chr3_159483781_159484285	0.16	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	1141	0.44
chr5_3197978_3198129	0.16	IRX1	iroquois homeobox 1	398115	0.01
chr7_55142263_55142544	0.16	EGFR	epidermal growth factor receptor	35013	0.22
chr21_17792302_17792515	0.16	ENSG00000207638	.	119001	0.06
chr12_30906652_30906803	0.16	CAPRIN2	caprin family member 2	518	0.86
chr4_95635906_95636061	0.16	BMPR1B	bone morphogenetic protein receptor, type IB	43136	0.21
chr2_317550_317840	0.16	FAM150B	family with sequence similarity 150, member B	28844	0.16
chr10_33630285_33630504	0.16	NRP1	neuropilin 1	5204	0.3
chr12_120246427_120246712	0.16	CIT	citron (rho-interacting, serine/threonine kinase 21)	5382	0.27
chr2_192416956_192417327	0.16	NABP1	nucleic acid binding protein 1	125721	0.05
chr10_26846446_26846738	0.16	ENSG00000199733	.	48074	0.17
chr11_19585849_19586032	0.15	ENSG00000265210	.	10917	0.19
chr15_77710885_77711123	0.15	PEAK1	pseudopodium-enriched atypical kinase 1	1438	0.39
chr17_48124761_48124984	0.15	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	8467	0.14
chr7_151297260_151297484	0.15	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	32067	0.18
chr6_19691587_19692480	0.15	ENSG00000200957	.	49273	0.18
chr14_53416976_53417370	0.15	FERMT2	fermitin family member 2	113	0.98
chr11_8290078_8290567	0.15	LMO1	LIM domain only 1 (rhombotin 1)	59	0.98
chr17_2151727_2151878	0.15	SMG6	SMG6 nonsense mediated mRNA decay factor	3596	0.15
chr9_66699115_66699266	0.15	ENSG00000206946	.	13544	0.3
chr10_25008347_25008498	0.15	ARHGAP21	Rho GTPase activating protein 21	2373	0.41
chr6_37105124_37105275	0.15	PIM1	pim-1 oncogene	32780	0.15
chr9_21555895_21556299	0.15	MIR31HG	MIR31 host gene (non-protein coding)	3571	0.22
chr10_112296305_112296649	0.15	SMC3	structural maintenance of chromosomes 3	30972	0.13
chr4_126311194_126311396	0.15	FAT4	FAT atypical cadherin 4	3796	0.32
chr1_78474827_78475270	0.15	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	4510	0.17
chr6_140859694_140859893	0.15	ENSG00000221336	.	122057	0.06
chr4_81192022_81192173	0.15	FGF5	fibroblast growth factor 5	4304	0.29
chr1_52456055_52456657	0.15	RAB3B	RAB3B, member RAS oncogene family	80	0.95
chr8_56901426_56901577	0.15	ENSG00000240905	.	8405	0.16
chr7_134465735_134465936	0.15	CALD1	caldesmon 1	1406	0.57
chr10_18453155_18453355	0.14	CACNB2	calcium channel, voltage-dependent, beta 2 subunit	23146	0.25
chr3_111717643_111718087	0.14	TAGLN3	transgelin 3	171	0.95
chr1_39877379_39877579	0.14	KIAA0754	KIAA0754	1328	0.41
chr8_38855409_38855789	0.14	ADAM9	ADAM metallopeptidase domain 9	1094	0.34
chr5_3560421_3560572	0.14	IRX1	iroquois homeobox 1	35672	0.2
chr2_238318512_238318719	0.14	COL6A3	collagen, type VI, alpha 3	4176	0.24
chr4_4576417_4576570	0.14	STX18-AS1	STX18 antisense RNA 1 (head to head)	32348	0.18
chr15_39985088_39985239	0.14	RP11-37C7.3		89609	0.07
chr15_52675291_52675442	0.14	MYO5A	myosin VA (heavy chain 12, myoxin)	31688	0.19
chr1_170639404_170639633	0.14	PRRX1	paired related homeobox 1	6440	0.31
chr5_58883529_58883730	0.14	PDE4D	phosphodiesterase 4D, cAMP-specific	1304	0.62
chr15_96886136_96886425	0.14	ENSG00000222651	.	9790	0.16
chr6_99796840_99797257	0.14	FAXC	failed axon connections homolog (Drosophila)	483	0.83
chr1_215178346_215178497	0.14	KCNK2	potassium channel, subfamily K, member 2	777	0.8
chr1_85873190_85873383	0.14	DDAH1	dimethylarginine dimethylaminohydrolase 1	3106	0.28
chr8_6456469_6456620	0.14	ANGPT2	angiopoietin 2	35614	0.18
chr2_239337309_239337646	0.14	AC016999.2		1107	0.42
chr2_202929676_202929827	0.14	AC079354.1	uncharacterized protein KIAA2012	8227	0.16
chr7_129934048_129934199	0.14	CPA4	carboxypeptidase A4	1004	0.45
chr3_61546098_61546562	0.14	PTPRG	protein tyrosine phosphatase, receptor type, G	1255	0.64
chr3_105657205_105657471	0.14	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	68942	0.15
chr7_18549207_18549425	0.14	HDAC9	histone deacetylase 9	380	0.92
chr10_128250315_128250594	0.14	ENSG00000221717	.	4821	0.29
chr19_15361458_15361910	0.14	EPHX3	epoxide hydrolase 3	17438	0.15
chr5_155409653_155409804	0.14	SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	112374	0.07
chr6_9116214_9116470	0.14	SLC35B3	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3	680548	0.0
chr10_116474996_116475239	0.14	ABLIM1	actin binding LIM protein 1	30703	0.21
chr12_79916269_79916420	0.14	ENSG00000243714	.	2606	0.3
chr11_33399282_33399433	0.14	ENSG00000223134	.	23346	0.23
chr5_171986318_171986532	0.14	AC027309.1		50011	0.13
chr3_55521292_55522040	0.14	WNT5A-AS1	WNT5A antisense RNA 1	61	0.83
chr4_87373379_87373575	0.13	MAPK10	mitogen-activated protein kinase 10	806	0.74
chr19_1361544_1361801	0.13	MUM1	melanoma associated antigen (mutated) 1	5309	0.1
chr10_119302142_119302346	0.13	EMX2	empty spiracles homeobox 2	265	0.64
chr5_110252790_110252941	0.13	TSLP	thymic stromal lymphopoietin	152895	0.04
chr7_130589596_130590032	0.13	ENSG00000226380	.	27516	0.22
chr8_87188438_87188625	0.13	CTD-3118D11.3		4116	0.24
chr1_182932139_182932350	0.13	ENSG00000264768	.	3534	0.19
chr14_33776607_33776786	0.13	NPAS3	neuronal PAS domain protein 3	92178	0.1
chr15_86162614_86163207	0.13	RP11-815J21.3		8010	0.15
chr10_92679511_92679800	0.13	ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	1378	0.39
chr15_71054590_71054766	0.13	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	1091	0.55
chr1_86079084_86079255	0.13	ENSG00000199934	.	21206	0.18
chr11_126506918_126507382	0.13	RP11-115C10.1		15597	0.26
chr9_18472965_18473116	0.13	ADAMTSL1	ADAMTS-like 1	852	0.75
chr9_91791007_91791172	0.13	SHC3	SHC (Src homology 2 domain containing) transforming protein 3	2593	0.36
chr5_2750019_2750705	0.13	IRX2	iroquois homeobox 2	1407	0.43
chr10_102761020_102761171	0.13	LZTS2	leucine zipper, putative tumor suppressor 2	1485	0.23
chr3_99989145_99989333	0.13	TBC1D23	TBC1 domain family, member 23	3203	0.26
chr7_126848587_126848738	0.13	AC000099.1		6519	0.26

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.3	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.3	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.3	GO:0022605	oogenesis stage(GO:0022605)
0.1	0.2	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.1	0.2	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.2	GO:0071504	cellular response to heparin(GO:0071504)
0.1	0.2	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.1	0.3	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.1	0.3	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.1	0.3	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.1	0.2	GO:0060013	righting reflex(GO:0060013)
0.1	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.2	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.2	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.2	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.3	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.1	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.3	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.1	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.5	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.1	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0033622	integrin activation(GO:0033622)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.0	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0048875	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.1	GO:0048343	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0	0.1	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.0	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.3	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0060174	limb bud formation(GO:0060174)
0.0	0.0	GO:0051014	actin filament severing(GO:0051014)
0.0	0.0	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.0	GO:0061430	bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0	0.1	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.0	GO:0048311	mitochondrion distribution(GO:0048311)
0.0	0.0	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.2	GO:0098743	cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0	0.0	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.2	GO:0035329	hippo signaling(GO:0035329)
0.0	0.0	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.0	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.0	GO:0048808	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.0	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.0	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.0	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.0	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.3	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.1	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.3	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0	0.0	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.4	GO:0071377	cellular response to glucagon stimulus(GO:0071377)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.3	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.2	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0005916	fascia adherens(GO:0005916)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.0	0.2	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.2	GO:0098878	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	1.0	GO:0030426	growth cone(GO:0030426)
0.0	0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.3	GO:0030131	clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.5	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.3	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1	0.3	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.2	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.2	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.3	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.4	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.0	GO:0034711	inhibin binding(GO:0034711)
0.0	0.3	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.2	GO:0043855	intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.3	GO:0005109	frizzled binding(GO:0005109)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.0	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.0	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.0	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.0	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.0	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0051378	serotonin binding(GO:0051378)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.0	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.0	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0005523	tropomyosin binding(GO:0005523)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.4	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.4	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.5	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.3	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.4	PID BMP PATHWAY	BMP receptor signaling
0.1	PID VEGFR1 PATHWAY	VEGFR1 specific signals

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.3	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.3	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.1	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.4	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.3	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.1	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.0	REACTOME SIGNALING BY ERBB4	Genes involved in Signaling by ERBB4
0.0	0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.1	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.1	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.0	REACTOME NEURONAL SYSTEM	Genes involved in Neuronal System
0.0	0.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.1	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen