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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for PITX2

Z-value: 1.47

Motif logo

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.11 paired like homeodomain 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr4_111557687_111558154PITX22560.954379-0.791.2e-02Click!
chr4_111557385_111557536PITX27160.790624-0.771.6e-02Click!
chr4_111532964_111533115PITX2111680.276361-0.761.9e-02Click!
chr4_111558170_111558322PITX2640.985579-0.752.1e-02Click!
chr4_111507244_111507551PITX2368100.189272-0.732.7e-02Click!

Activity of the PITX2 motif across conditions

Conditions sorted by the z-value of the PITX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr16_30484007_30484505 0.55 ITGAL
 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
 184
 0.81
chr19_2084975_2085126 0.54 MOB3A
 MOB kinase activator 3A
 341
 0.8
chr12_122287932_122288083 0.53 RP11-7M8.2
6158
 0.15
chr19_2084034_2084229 0.51 MOB3A
 MOB kinase activator 3A
 1260
 0.31
chr17_29640289_29640482 0.48 EVI2B
 ecotropic viral integration site 2B
 717
 0.57
chr5_130588828_130589214 0.46 CDC42SE2
 CDC42 small effector 2
 10681
 0.28
chr12_9911780_9911931 0.44 CD69
 CD69 molecule
 1642
 0.33
chr13_46751053_46751538 0.42 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
 5164
 0.18
chr10_101414814_101414965 0.41 RP11-483F11.7
1227
 0.38
chr19_8642522_8642673 0.41 MYO1F
 myosin IF
 136
 0.93
chr4_40201423_40201705 0.41 RHOH
 ras homolog family member H
 400
 0.87
chr1_226073126_226073382 0.40 TMEM63A
 transmembrane protein 63A
 3185
 0.16
chr9_117147390_117147560 0.40 AKNA
 AT-hook transcription factor
 2768
 0.28
chr7_73624740_73625015 0.39 LAT2
 linker for activation of T cells family, member 2
 524
 0.74
chr6_154568354_154568864 0.37 IPCEF1
 interaction protein for cytohesin exchange factors 1
 53
 0.99
chr1_209942353_209942874 0.36 TRAF3IP3
 TRAF3 interacting protein 3
 653
 0.63
chr16_11678677_11678828 0.35 LITAF
 lipopolysaccharide-induced TNF factor
 1477
 0.42
chr2_101916869_101917041 0.35 RNF149
 ring finger protein 149
 8203
 0.17
chr15_40599321_40599893 0.35 PLCB2
 phospholipase C, beta 2
 419
 0.68
chr1_244488212_244488377 0.34 C1orf100
 chromosome 1 open reading frame 100
 27643
 0.22
chr6_159465648_159465970 0.34 TAGAP
 T-cell activation RhoGTPase activating protein
 241
 0.93
chrX_118825241_118825467 0.34 SEPT6
 septin 6
 1438
 0.4
chr2_161993917_161994236 0.33 TANK
 TRAF family member-associated NFKB activator
 610
 0.79
chr1_175158346_175158497 0.33 KIAA0040
 KIAA0040
 3469
 0.33
chr5_95155660_95155831 0.33 GLRX
 glutaredoxin (thioltransferase)
 2670
 0.22
chr8_23083253_23083404 0.33 ENSG00000246582
 .
 594
 0.43
chr9_71590240_71590555 0.33 PRKACG
 protein kinase, cAMP-dependent, catalytic, gamma
 38642
 0.15
chr10_28622520_28622887 0.33 MPP7
 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
 712
 0.72
chr17_33863104_33863360 0.32 SLFN12L
 schlafen family member 12-like
 1648
 0.24
chr1_248069833_248069987 0.32 OR2W3
 olfactory receptor, family 2, subfamily W, member 3
 11021
 0.1
chr17_47818679_47819212 0.32 FAM117A
 family with sequence similarity 117, member A
 17056
 0.14
chr15_40366035_40366186 0.31 RP11-521C20.3
14923
 0.14
chr1_150849308_150849506 0.31 ARNT
 aryl hydrocarbon receptor nuclear translocator
 163
 0.93
chr17_33863414_33863594 0.31 SLFN12L
 schlafen family member 12-like
 1376
 0.29
chr4_170000682_170000833 0.31 RP11-483A20.3
69176
 0.1
chr2_24114630_24115019 0.31 ATAD2B
 ATPase family, AAA domain containing 2B
 24067
 0.18
chr18_9084010_9084262 0.30 NDUFV2
 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
 18492
 0.17
chr12_32113291_32114105 0.30 KIAA1551
 KIAA1551
 1345
 0.51
chr17_76776568_76776719 0.30 CYTH1
 cytohesin 1
 1711
 0.35
chr1_160766445_160766727 0.30 LY9
 lymphocyte antigen 9
 609
 0.72
chr12_50937322_50937473 0.30 DIP2B
 DIP2 disco-interacting protein 2 homolog B (Drosophila)
 38507
 0.16
chr3_32502059_32502315 0.30 CMTM6
 CKLF-like MARVEL transmembrane domain containing 6
 42713
 0.15
chr2_75067589_75067763 0.30 HK2
 hexokinase 2
 5379
 0.28
chr1_39499733_39499961 0.29 NDUFS5
 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
 7857
 0.18
chr2_106417256_106417407 0.29 NCK2
 NCK adaptor protein 2
 15684
 0.26
chr3_95425254_95425405 0.29 ENSG00000221477
 .
 460417
 0.01
chr12_51714054_51714205 0.29 BIN2
 bridging integrator 2
 3770
 0.19
chr6_167461487_167461638 0.29 FGFR1OP
 FGFR1 oncogene partner
 48666
 0.1
chr2_198071025_198071176 0.29 ANKRD44
 ankyrin repeat domain 44
 8338
 0.21
chr1_206749362_206749620 0.29 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 18998
 0.14
chr2_238605925_238606076 0.28 LRRFIP1
 leucine rich repeat (in FLII) interacting protein 1
 5018
 0.26
chr5_39274254_39274635 0.28 FYB
 FYN binding protein
 186
 0.97
chr19_59049459_59049613 0.28 ZBTB45
 zinc finger and BTB domain containing 45
 742
 0.4
chr18_66429429_66429580 0.28 RP11-106E15.1
7684
 0.22
chr20_3996304_3996483 0.28 RNF24
 ring finger protein 24
 164
 0.96
chr20_55975682_55975833 0.27 RP4-800J21.3
7639
 0.16
chr13_30949154_30949340 0.27 KATNAL1
 katanin p60 subunit A-like 1
 67626
 0.12
chr19_16441170_16441321 0.27 KLF2
 Kruppel-like factor 2
 5594
 0.16
chr14_93123309_93123460 0.27 RIN3
 Ras and Rab interactor 3
 4538
 0.3
chr17_29136154_29136502 0.27 CRLF3
 cytokine receptor-like factor 3
 15361
 0.12
chr17_28048860_28049057 0.27 RP11-82O19.1
39163
 0.1
chr8_131330583_131330734 0.27 ASAP1
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
 22525
 0.27
chr14_65006652_65007080 0.26 RP11-973N13.4
220
 0.6
chr3_50656380_50656531 0.26 MAPKAPK3
 mitogen-activated protein kinase-activated protein kinase 3
 1634
 0.31
chr1_150976139_150976311 0.26 FAM63A
 family with sequence similarity 63, member A
 2736
 0.12
chr7_72407870_72408021 0.26 RP11-313P13.5
12282
 0.1
chr11_64532141_64532616 0.26 SF1
 splicing factor 1
 2711
 0.16
chr1_117299964_117300188 0.26 CD2
 CD2 molecule
 2987
 0.29
chr1_246740599_246740764 0.26 CNST
 consortin, connexin sorting protein
 10865
 0.17
chr18_10290164_10290429 0.26 ENSG00000239031
 .
 99701
 0.08
chr5_126094875_126095026 0.25 ENSG00000252185
 .
 3841
 0.27
chr3_32997666_32997928 0.25 CCR4
 chemokine (C-C motif) receptor 4
 4731
 0.29
chr4_40211316_40211467 0.25 RHOH
 ras homolog family member H
 9427
 0.22
chrX_118813168_118813330 0.25 SEPT6
 septin 6
 13543
 0.17
chr16_21656376_21656527 0.25 ENSG00000207042
 .
 2836
 0.16
chr7_72705892_72706043 0.25 GTF2IRD2P1
 GTF2I repeat domain containing 2 pseudogene 1
 11824
 0.13
chr19_17377966_17378117 0.25 BABAM1
 BRISC and BRCA1 A complex member 1
 118
 0.9
chr2_71299479_71299745 0.25 NAGK
 N-acetylglucosamine kinase
 691
 0.54
chr6_90122617_90122768 0.25 RRAGD
 Ras-related GTP binding D
 703
 0.69
chr1_150976711_150976969 0.24 FAM63A
 family with sequence similarity 63, member A
 2121
 0.14
chrX_70331856_70332007 0.24 IL2RG
 interleukin 2 receptor, gamma
 27
 0.95
chr11_128171806_128172037 0.24 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 203368
 0.03
chr16_3627461_3627612 0.24 NLRC3
 NLR family, CARD domain containing 3
 135
 0.95
chr19_8567892_8568043 0.24 PRAM1
 PML-RARA regulated adaptor molecule 1
 29
 0.96
chr13_41554921_41555161 0.24 ELF1
 E74-like factor 1 (ets domain transcription factor)
 1377
 0.45
chr2_65173224_65173438 0.24 ENSG00000238696
 .
 37511
 0.12
chr2_197127548_197127913 0.24 AC020571.3
2573
 0.29
chrX_70415693_70415844 0.24 RP5-1091N2.9
2257
 0.22
chr10_14601825_14601976 0.24 FAM107B
 family with sequence similarity 107, member B
 3721
 0.3
chr15_64984890_64985206 0.24 AC100830.4
2192
 0.18
chr1_150540056_150540997 0.23 ENSG00000264508
 .
 1190
 0.22
chr1_198646318_198646469 0.23 RP11-553K8.5
10203
 0.25
chr19_54881402_54882266 0.23 LAIR1
 leukocyte-associated immunoglobulin-like receptor 1
 224
 0.88
chr11_65129750_65129901 0.23 RP11-867O8.5
5084
 0.11
chr6_2941043_2941270 0.23 SERPINB6
 serpin peptidase inhibitor, clade B (ovalbumin), member 6
 20405
 0.14
chr10_69146333_69146514 0.23 CTNNA3
 catenin (cadherin-associated protein), alpha 3
 206222
 0.03
chr1_239882649_239882800 0.23 CHRM3
 cholinergic receptor, muscarinic 3
 119
 0.79
chr19_14886284_14886435 0.23 EMR2
 egf-like module containing, mucin-like, hormone receptor-like 2
 1209
 0.4
chr11_118086318_118086469 0.23 AMICA1
 adhesion molecule, interacts with CXADR antigen 1
 787
 0.57
chr20_34331618_34331769 0.23 RBM39
 RNA binding motif protein 39
 1459
 0.29
chr14_35016119_35016807 0.23 ENSG00000206596
 .
 543
 0.71
chr22_51059908_51060313 0.22 ARSA
 arylsulfatase A
 6473
 0.1
chr12_76662658_76662809 0.22 ENSG00000223273
 .
 46798
 0.16
chr12_122065838_122066280 0.22 ORAI1
 ORAI calcium release-activated calcium modulator 1
 1338
 0.42
chr8_67341017_67341168 0.22 RRS1
 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
 171
 0.93
chr7_114566088_114566321 0.22 MDFIC
 MyoD family inhibitor domain containing
 3073
 0.4
chr10_6095725_6095937 0.22 IL2RA
 interleukin 2 receptor, alpha
 8422
 0.15
chr3_176916851_176917002 0.22 TBL1XR1
 transducin (beta)-like 1 X-linked receptor 1
 1665
 0.48
chr6_11727513_11727664 0.22 ADTRP
 androgen-dependent TFPI-regulating protein
 8301
 0.25
chr21_15921648_15921799 0.22 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 3059
 0.32
chr5_14582511_14582672 0.22 FAM105A
 family with sequence similarity 105, member A
 707
 0.77
chr19_55009541_55009776 0.22 LAIR2
 leukocyte-associated immunoglobulin-like receptor 2
 558
 0.61
chr9_132565219_132565403 0.22 TOR1B
 torsin family 1, member B (torsin B)
 121
 0.95
chr1_145382873_145383278 0.22 ENSG00000201558
 .
 318
 0.87
chr16_85793355_85793506 0.22 C16orf74
 chromosome 16 open reading frame 74
 8695
 0.11
chr10_30818638_30818892 0.22 ENSG00000239744
 .
 26068
 0.21
chr13_28001325_28001476 0.22 GTF3A
 general transcription factor IIIA
 2695
 0.24
chr10_26731274_26731437 0.21 APBB1IP
 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
 4001
 0.33
chr3_5231543_5231696 0.21 EDEM1
 ER degradation enhancer, mannosidase alpha-like 1
 1585
 0.26
chr2_106776864_106777181 0.21 UXS1
 UDP-glucuronate decarboxylase 1
 18
 0.98
chr12_50908112_50908263 0.21 DIP2B
 DIP2 disco-interacting protein 2 homolog B (Drosophila)
 9297
 0.23
chr16_89449371_89449542 0.21 RP1-168P16.2
29516
 0.11
chr14_91865794_91865945 0.21 CCDC88C
 coiled-coil domain containing 88C
 17821
 0.22
chr17_36452726_36452901 0.21 MRPL45
 mitochondrial ribosomal protein L45
 176
 0.94
chr17_41446028_41446236 0.21 ENSG00000188825
 .
 18653
 0.11
chr17_33376713_33376864 0.21 ENSG00000238858
 .
 4725
 0.13
chr22_40299734_40299885 0.21 GRAP2
 GRB2-related adaptor protein 2
 2696
 0.25
chr20_821090_821241 0.21 FAM110A
 family with sequence similarity 110, member A
 4120
 0.27
chr15_38854702_38854853 0.21 RASGRP1
 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
 2059
 0.32
chr1_45769094_45769262 0.21 HPDL
 4-hydroxyphenylpyruvate dioxygenase-like
 23367
 0.14
chrX_129225529_129225680 0.21 ELF4
 E74-like factor 4 (ets domain transcription factor)
 18732
 0.19
chr22_41033042_41033281 0.21 MKL1
 megakaryoblastic leukemia (translocation) 1
 466
 0.84
chr4_89534455_89534711 0.21 HERC3
 HECT and RLD domain containing E3 ubiquitin protein ligase 3
 7638
 0.19
chr21_34776986_34777191 0.21 IFNGR2
 interferon gamma receptor 2 (interferon gamma transducer 1)
 1316
 0.43
chr22_31139652_31139831 0.21 ENSG00000264661
 .
 12197
 0.17
chr1_28879171_28879359 0.20 TRNAU1AP
 tRNA selenocysteine 1 associated protein 1
 332
 0.8
chr19_6425167_6425318 0.20 KHSRP
 KH-type splicing regulatory protein
 437
 0.66
chr10_73529493_73529671 0.20 C10orf54
 chromosome 10 open reading frame 54
 3673
 0.23
chr15_34609507_34609658 0.20 SLC12A6
 solute carrier family 12 (potassium/chloride transporter), member 6
 1398
 0.29
chr12_47611625_47611801 0.20 PCED1B
 PC-esterase domain containing 1B
 1332
 0.49
chr15_75230580_75230787 0.20 COX5A
 cytochrome c oxidase subunit Va
 174
 0.92
chrX_123096191_123096863 0.20 STAG2
 stromal antigen 2
 493
 0.85
chr17_76771796_76772004 0.20 CYTH1
 cytohesin 1
 6454
 0.2
chr21_46300234_46300404 0.20 PTTG1IP
 pituitary tumor-transforming 1 interacting protein
 6567
 0.13
chr1_212461608_212461798 0.20 PPP2R5A
 protein phosphatase 2, regulatory subunit B', alpha
 2824
 0.24
chr19_10706452_10706725 0.20 SLC44A2
 solute carrier family 44 (choline transporter), member 2
 6545
 0.1
chr15_93458767_93458918 0.20 CHD2
 chromodomain helicase DNA binding protein 2
 11139
 0.19
chr11_60213804_60213975 0.20 MS4A1
 membrane-spanning 4-domains, subfamily A, member 1
 9336
 0.16
chr4_39429086_39429237 0.20 ENSG00000238797
 .
 14124
 0.11
chr19_54875923_54876565 0.20 LAIR1
 leukocyte-associated immunoglobulin-like receptor 1
 170
 0.91
chr1_231666043_231666200 0.20 TSNAX
 translin-associated factor X
 1720
 0.31
chr6_34283894_34284092 0.20 C6orf1
 chromosome 6 open reading frame 1
 66746
 0.09
chr14_77330807_77330958 0.20 ENSG00000223174
 .
 25724
 0.16
chr16_84603491_84603642 0.20 TLDC1
 TBC/LysM-associated domain containing 1
 15927
 0.16
chr4_1195622_1195773 0.20 SPON2
 spondin 2, extracellular matrix protein
 3179
 0.18
chrX_8150685_8150836 0.20 VCX2
 variable charge, X-linked 2
 11452
 0.28
chr7_99070141_99070303 0.20 ZNF789
 zinc finger protein 789
 242
 0.83
chr2_190442967_190443214 0.20 SLC40A1
 solute carrier family 40 (iron-regulated transporter), member 1
 2523
 0.35
chr15_80262648_80263745 0.20 BCL2A1
 BCL2-related protein A1
 315
 0.89
chr2_37762882_37763076 0.20 AC006369.2
64300
 0.12
chr20_2311261_2311412 0.19 TGM3
 transglutaminase 3
 34689
 0.16
chr12_58230016_58230207 0.19 RP11-620J15.1
764
 0.44
chr2_223290336_223290619 0.19 SGPP2
 sphingosine-1-phosphate phosphatase 2
 1241
 0.5
chr11_118213153_118213331 0.19 CD3D
 CD3d molecule, delta (CD3-TCR complex)
 104
 0.93
chr12_124155262_124155441 0.19 TCTN2
 tectonic family member 2
 309
 0.86
chr21_36420108_36421159 0.19 RUNX1
 runt-related transcription factor 1
 829
 0.77
chr19_46179944_46180134 0.19 ENSG00000207773
 .
 1853
 0.16
chr17_45570068_45570247 0.19 MRPL45P2
 mitochondrial ribosomal protein L45 pseudogene 2
 332
 0.88
chr1_243430515_243430666 0.19 SDCCAG8
 serologically defined colon cancer antigen 8
 11218
 0.19
chr2_136504991_136505142 0.19 UBXN4
 UBX domain protein 4
 5762
 0.21
chr12_94517592_94517768 0.19 PLXNC1
 plexin C1
 24819
 0.2
chr1_22351357_22351739 0.19 ENSG00000201273
 .
 14070
 0.09
chr21_47035540_47035741 0.19 PCBP3
 poly(rC) binding protein 3
 27968
 0.2
chr12_132469658_132469809 0.19 ENSG00000271905
 .
 16587
 0.15
chr13_40397451_40397602 0.19 ENSG00000212553
 .
 33838
 0.19
chr7_76828015_76828166 0.19 FGL2
 fibrinogen-like 2
 1053
 0.59
chrX_109708973_109709124 0.19 RGAG1
 retrotransposon gag domain containing 1
 15255
 0.23
chr6_53209536_53209824 0.19 ELOVL5
 ELOVL fatty acid elongase 5
 3907
 0.26
chr17_56419518_56419935 0.19 BZRAP1-AS1
 BZRAP1 antisense RNA 1
 5007
 0.12
chr8_65607910_65608061 0.19 RP11-1D12.1
39031
 0.2
chr12_65058254_65058405 0.19 RP11-338E21.3
9530
 0.14
chr19_59055180_59055577 0.19 TRIM28
 tripartite motif containing 28
 80
 0.82
chr17_78991849_78992000 0.19 AC127496.1
 Uncharacterized protein
 14789
 0.11
chr14_81629657_81629808 0.18 RP11-114N19.3
7026
 0.24
chr12_40012002_40012194 0.18 ABCD2
 ATP-binding cassette, sub-family D (ALD), member 2
 1455
 0.48
chr4_185741986_185742137 0.18 ACSL1
 acyl-CoA synthetase long-chain family member 1
 5127
 0.2
chr10_120891057_120891670 0.18 FAM45A
 family with sequence similarity 45, member A
 27734
 0.11
chr1_212927626_212927881 0.18 NSL1
 NSL1, MIS12 kinetochore complex component
 37170
 0.12
chr1_154581072_154581232 0.18 ADAR
 adenosine deaminase, RNA-specific
 470
 0.73
chr1_155946704_155947008 0.18 ARHGEF2
 Rho/Rac guanine nucleotide exchange factor (GEF) 2
 1095
 0.29
chr1_147994918_147995202 0.18 ENSG00000212456
 .
 914
 0.59
chr17_18966559_18966712 0.18 ENSG00000262074
 .
 814
 0.4
chr2_175456985_175457136 0.18 WIPF1
 WAS/WASL interacting protein family, member 1
 5433
 0.19
chrY_21906454_21906814 0.18 KDM5D
 lysine (K)-specific demethylase 5D
 13
 0.99
chr2_220117396_220117589 0.18 TUBA4A
 tubulin, alpha 4a
 223
 0.82
chr14_32366460_32366611 0.18 RP11-187E13.1
 Uncharacterized protein
 47524
 0.17
chr21_35885755_35885906 0.18 KCNE1
 potassium voltage-gated channel, Isk-related family, member 1
 1257
 0.46
chr19_4975873_4976024 0.18 KDM4B
 lysine (K)-specific demethylase 4B
 6805
 0.19
chr10_64915626_64915777 0.18 NRBF2
 nuclear receptor binding factor 2
 22616
 0.18
chr1_148766073_148766315 0.18 ENSG00000206968
 .
 908
 0.66

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1 0.1 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618)
0.1 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.2 GO:0051138 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0042494 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.2 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.3 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0072239 metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.2 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0016139 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0 0.2 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.2 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.0 0.2 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0032418 lysosome localization(GO:0032418)
0.0 0.1 GO:0046931 pore complex assembly(GO:0046931)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0010834 obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0 0.1 GO:0032025 response to cobalt ion(GO:0032025)
0.0 0.5 GO:0002448 mast cell mediated immunity(GO:0002448)
0.0 0.1 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.0 0.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.5 GO:0050798 activated T cell proliferation(GO:0050798)
0.0 0.1 GO:0050685 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.0 0.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.2 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:0016246 RNA interference(GO:0016246)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0072698 protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0009650 UV protection(GO:0009650)
0.0 0.3 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.5 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0009299 mRNA transcription(GO:0009299)
0.0 0.1 GO:0016553 base conversion or substitution editing(GO:0016553)
0.0 0.0 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.0 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.2 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.1 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.0 0.1 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.1 GO:0002507 tolerance induction(GO:0002507)
0.0 0.1 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0071230 cellular response to amino acid stimulus(GO:0071230)
0.0 0.1 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0 0.1 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.0 GO:0048478 replication fork protection(GO:0048478)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 0.1 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0 0.0 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.0 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0 0.0 GO:0046606 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0 0.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.0 GO:0007144 female meiosis I(GO:0007144)
0.0 0.0 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0007141 male meiosis I(GO:0007141)
0.0 0.1 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.1 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
0.0 0.0 GO:0070266 necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0 0.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.0 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.0 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.0 GO:0009173 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.0 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.0 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.1 GO:0032770 positive regulation of monooxygenase activity(GO:0032770)
0.0 0.0 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.0 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.0 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.0 GO:0045056 transcytosis(GO:0045056)
0.0 0.0 GO:0090201 negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0 0.0 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.0 GO:0032966 negative regulation of collagen biosynthetic process(GO:0032966)
0.0 0.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.1 GO:0032372 negative regulation of sterol transport(GO:0032372) negative regulation of cholesterol transport(GO:0032375)
0.0 0.2 GO:0051225 spindle assembly(GO:0051225)
0.0 0.0 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0032715 negative regulation of interleukin-6 production(GO:0032715)
0.0 0.1 GO:0048261 negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0 0.0 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.0 0.0 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 0.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.0 GO:0008216 spermidine metabolic process(GO:0008216)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.2 GO:0070552 BRISC complex(GO:0070552)
0.1 0.4 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.5 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.2 GO:0031105 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.0 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.0 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.0 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.2 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0005669 transcription factor TFIID complex(GO:0005669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.3 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.2 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.2 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.1 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.1 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.0 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.0 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.0 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.2 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0 0.2 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.1 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0017069 snRNA binding(GO:0017069)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.0 GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0 0.1 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.3 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.2 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.4 PID ATM PATHWAY ATM pathway
0.0 0.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.3 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.2 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME SIGNALING BY FGFR IN DISEASE Genes involved in Signaling by FGFR in disease
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.1 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.1 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.2 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.6 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.2 REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.4 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling