Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PITX2

Z-value: 1.47

Motif logo

Transcription factors associated with PITX2

Gene Symbol	Gene ID	Gene Info
PITX2 Ensembl NCBI GeneCards UniProt	ENSG00000164093.11	PITX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PITX2	chr4_111557687_111558154	256	0.954379	-0.79	1.2e-02	Click!
PITX2	chr4_111557385_111557536	716	0.790624	-0.77	1.6e-02	Click!
PITX2	chr4_111532964_111533115	11168	0.276361	-0.76	1.9e-02	Click!
PITX2	chr4_111558170_111558322	64	0.985579	-0.75	2.1e-02	Click!
PITX2	chr4_111507244_111507551	36810	0.189272	-0.73	2.7e-02	Click!

Activity of the PITX2 motif across conditions

Conditions sorted by the z-value of the PITX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_30484007_30484505	0.55	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	184	0.81
chr19_2084975_2085126	0.54	MOB3A	MOB kinase activator 3A	341	0.8
chr12_122287932_122288083	0.53	RP11-7M8.2		6158	0.15
chr19_2084034_2084229	0.51	MOB3A	MOB kinase activator 3A	1260	0.31
chr17_29640289_29640482	0.48	EVI2B	ecotropic viral integration site 2B	717	0.57
chr5_130588828_130589214	0.46	CDC42SE2	CDC42 small effector 2	10681	0.28
chr12_9911780_9911931	0.44	CD69	CD69 molecule	1642	0.33
chr13_46751053_46751538	0.42	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	5164	0.18
chr10_101414814_101414965	0.41	RP11-483F11.7		1227	0.38
chr19_8642522_8642673	0.41	MYO1F	myosin IF	136	0.93
chr4_40201423_40201705	0.41	RHOH	ras homolog family member H	400	0.87
chr1_226073126_226073382	0.40	TMEM63A	transmembrane protein 63A	3185	0.16
chr9_117147390_117147560	0.40	AKNA	AT-hook transcription factor	2768	0.28
chr7_73624740_73625015	0.39	LAT2	linker for activation of T cells family, member 2	524	0.74
chr6_154568354_154568864	0.37	IPCEF1	interaction protein for cytohesin exchange factors 1	53	0.99
chr1_209942353_209942874	0.36	TRAF3IP3	TRAF3 interacting protein 3	653	0.63
chr16_11678677_11678828	0.35	LITAF	lipopolysaccharide-induced TNF factor	1477	0.42
chr2_101916869_101917041	0.35	RNF149	ring finger protein 149	8203	0.17
chr15_40599321_40599893	0.35	PLCB2	phospholipase C, beta 2	419	0.68
chr1_244488212_244488377	0.34	C1orf100	chromosome 1 open reading frame 100	27643	0.22
chr6_159465648_159465970	0.34	TAGAP	T-cell activation RhoGTPase activating protein	241	0.93
chrX_118825241_118825467	0.34	SEPT6	septin 6	1438	0.4
chr2_161993917_161994236	0.33	TANK	TRAF family member-associated NFKB activator	610	0.79
chr1_175158346_175158497	0.33	KIAA0040	KIAA0040	3469	0.33
chr5_95155660_95155831	0.33	GLRX	glutaredoxin (thioltransferase)	2670	0.22
chr8_23083253_23083404	0.33	ENSG00000246582	.	594	0.43
chr9_71590240_71590555	0.33	PRKACG	protein kinase, cAMP-dependent, catalytic, gamma	38642	0.15
chr10_28622520_28622887	0.33	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	712	0.72
chr17_33863104_33863360	0.32	SLFN12L	schlafen family member 12-like	1648	0.24
chr1_248069833_248069987	0.32	OR2W3	olfactory receptor, family 2, subfamily W, member 3	11021	0.1
chr17_47818679_47819212	0.32	FAM117A	family with sequence similarity 117, member A	17056	0.14
chr15_40366035_40366186	0.31	RP11-521C20.3		14923	0.14
chr1_150849308_150849506	0.31	ARNT	aryl hydrocarbon receptor nuclear translocator	163	0.93
chr17_33863414_33863594	0.31	SLFN12L	schlafen family member 12-like	1376	0.29
chr4_170000682_170000833	0.31	RP11-483A20.3		69176	0.1
chr2_24114630_24115019	0.31	ATAD2B	ATPase family, AAA domain containing 2B	24067	0.18
chr18_9084010_9084262	0.30	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	18492	0.17
chr12_32113291_32114105	0.30	KIAA1551	KIAA1551	1345	0.51
chr17_76776568_76776719	0.30	CYTH1	cytohesin 1	1711	0.35
chr1_160766445_160766727	0.30	LY9	lymphocyte antigen 9	609	0.72
chr12_50937322_50937473	0.30	DIP2B	DIP2 disco-interacting protein 2 homolog B (Drosophila)	38507	0.16
chr3_32502059_32502315	0.30	CMTM6	CKLF-like MARVEL transmembrane domain containing 6	42713	0.15
chr2_75067589_75067763	0.30	HK2	hexokinase 2	5379	0.28
chr1_39499733_39499961	0.29	NDUFS5	NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)	7857	0.18
chr2_106417256_106417407	0.29	NCK2	NCK adaptor protein 2	15684	0.26
chr3_95425254_95425405	0.29	ENSG00000221477	.	460417	0.01
chr12_51714054_51714205	0.29	BIN2	bridging integrator 2	3770	0.19
chr6_167461487_167461638	0.29	FGFR1OP	FGFR1 oncogene partner	48666	0.1
chr2_198071025_198071176	0.29	ANKRD44	ankyrin repeat domain 44	8338	0.21
chr1_206749362_206749620	0.29	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	18998	0.14
chr2_238605925_238606076	0.28	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	5018	0.26
chr5_39274254_39274635	0.28	FYB	FYN binding protein	186	0.97
chr19_59049459_59049613	0.28	ZBTB45	zinc finger and BTB domain containing 45	742	0.4
chr18_66429429_66429580	0.28	RP11-106E15.1		7684	0.22
chr20_3996304_3996483	0.28	RNF24	ring finger protein 24	164	0.96
chr20_55975682_55975833	0.27	RP4-800J21.3		7639	0.16
chr13_30949154_30949340	0.27	KATNAL1	katanin p60 subunit A-like 1	67626	0.12
chr19_16441170_16441321	0.27	KLF2	Kruppel-like factor 2	5594	0.16
chr14_93123309_93123460	0.27	RIN3	Ras and Rab interactor 3	4538	0.3
chr17_29136154_29136502	0.27	CRLF3	cytokine receptor-like factor 3	15361	0.12
chr17_28048860_28049057	0.27	RP11-82O19.1		39163	0.1
chr8_131330583_131330734	0.27	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	22525	0.27
chr14_65006652_65007080	0.26	RP11-973N13.4		220	0.6
chr3_50656380_50656531	0.26	MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	1634	0.31
chr1_150976139_150976311	0.26	FAM63A	family with sequence similarity 63, member A	2736	0.12
chr7_72407870_72408021	0.26	RP11-313P13.5		12282	0.1
chr11_64532141_64532616	0.26	SF1	splicing factor 1	2711	0.16
chr1_117299964_117300188	0.26	CD2	CD2 molecule	2987	0.29
chr1_246740599_246740764	0.26	CNST	consortin, connexin sorting protein	10865	0.17
chr18_10290164_10290429	0.26	ENSG00000239031	.	99701	0.08
chr5_126094875_126095026	0.25	ENSG00000252185	.	3841	0.27
chr3_32997666_32997928	0.25	CCR4	chemokine (C-C motif) receptor 4	4731	0.29
chr4_40211316_40211467	0.25	RHOH	ras homolog family member H	9427	0.22
chrX_118813168_118813330	0.25	SEPT6	septin 6	13543	0.17
chr16_21656376_21656527	0.25	ENSG00000207042	.	2836	0.16
chr7_72705892_72706043	0.25	GTF2IRD2P1	GTF2I repeat domain containing 2 pseudogene 1	11824	0.13
chr19_17377966_17378117	0.25	BABAM1	BRISC and BRCA1 A complex member 1	118	0.9
chr2_71299479_71299745	0.25	NAGK	N-acetylglucosamine kinase	691	0.54
chr6_90122617_90122768	0.25	RRAGD	Ras-related GTP binding D	703	0.69
chr1_150976711_150976969	0.24	FAM63A	family with sequence similarity 63, member A	2121	0.14
chrX_70331856_70332007	0.24	IL2RG	interleukin 2 receptor, gamma	27	0.95
chr11_128171806_128172037	0.24	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	203368	0.03
chr16_3627461_3627612	0.24	NLRC3	NLR family, CARD domain containing 3	135	0.95
chr19_8567892_8568043	0.24	PRAM1	PML-RARA regulated adaptor molecule 1	29	0.96
chr13_41554921_41555161	0.24	ELF1	E74-like factor 1 (ets domain transcription factor)	1377	0.45
chr2_65173224_65173438	0.24	ENSG00000238696	.	37511	0.12
chr2_197127548_197127913	0.24	AC020571.3		2573	0.29
chrX_70415693_70415844	0.24	RP5-1091N2.9		2257	0.22
chr10_14601825_14601976	0.24	FAM107B	family with sequence similarity 107, member B	3721	0.3
chr15_64984890_64985206	0.24	AC100830.4		2192	0.18
chr1_150540056_150540997	0.23	ENSG00000264508	.	1190	0.22
chr1_198646318_198646469	0.23	RP11-553K8.5		10203	0.25
chr19_54881402_54882266	0.23	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	224	0.88
chr11_65129750_65129901	0.23	RP11-867O8.5		5084	0.11
chr6_2941043_2941270	0.23	SERPINB6	serpin peptidase inhibitor, clade B (ovalbumin), member 6	20405	0.14
chr10_69146333_69146514	0.23	CTNNA3	catenin (cadherin-associated protein), alpha 3	206222	0.03
chr1_239882649_239882800	0.23	CHRM3	cholinergic receptor, muscarinic 3	119	0.79
chr19_14886284_14886435	0.23	EMR2	egf-like module containing, mucin-like, hormone receptor-like 2	1209	0.4
chr11_118086318_118086469	0.23	AMICA1	adhesion molecule, interacts with CXADR antigen 1	787	0.57
chr20_34331618_34331769	0.23	RBM39	RNA binding motif protein 39	1459	0.29
chr14_35016119_35016807	0.23	ENSG00000206596	.	543	0.71
chr22_51059908_51060313	0.22	ARSA	arylsulfatase A	6473	0.1
chr12_76662658_76662809	0.22	ENSG00000223273	.	46798	0.16
chr12_122065838_122066280	0.22	ORAI1	ORAI calcium release-activated calcium modulator 1	1338	0.42
chr8_67341017_67341168	0.22	RRS1	RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)	171	0.93
chr7_114566088_114566321	0.22	MDFIC	MyoD family inhibitor domain containing	3073	0.4
chr10_6095725_6095937	0.22	IL2RA	interleukin 2 receptor, alpha	8422	0.15
chr3_176916851_176917002	0.22	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	1665	0.48
chr6_11727513_11727664	0.22	ADTRP	androgen-dependent TFPI-regulating protein	8301	0.25
chr21_15921648_15921799	0.22	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	3059	0.32
chr5_14582511_14582672	0.22	FAM105A	family with sequence similarity 105, member A	707	0.77
chr19_55009541_55009776	0.22	LAIR2	leukocyte-associated immunoglobulin-like receptor 2	558	0.61
chr9_132565219_132565403	0.22	TOR1B	torsin family 1, member B (torsin B)	121	0.95
chr1_145382873_145383278	0.22	ENSG00000201558	.	318	0.87
chr16_85793355_85793506	0.22	C16orf74	chromosome 16 open reading frame 74	8695	0.11
chr10_30818638_30818892	0.22	ENSG00000239744	.	26068	0.21
chr13_28001325_28001476	0.22	GTF3A	general transcription factor IIIA	2695	0.24
chr10_26731274_26731437	0.21	APBB1IP	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	4001	0.33
chr3_5231543_5231696	0.21	EDEM1	ER degradation enhancer, mannosidase alpha-like 1	1585	0.26
chr2_106776864_106777181	0.21	UXS1	UDP-glucuronate decarboxylase 1	18	0.98
chr12_50908112_50908263	0.21	DIP2B	DIP2 disco-interacting protein 2 homolog B (Drosophila)	9297	0.23
chr16_89449371_89449542	0.21	RP1-168P16.2		29516	0.11
chr14_91865794_91865945	0.21	CCDC88C	coiled-coil domain containing 88C	17821	0.22
chr17_36452726_36452901	0.21	MRPL45	mitochondrial ribosomal protein L45	176	0.94
chr17_41446028_41446236	0.21	ENSG00000188825	.	18653	0.11
chr17_33376713_33376864	0.21	ENSG00000238858	.	4725	0.13
chr22_40299734_40299885	0.21	GRAP2	GRB2-related adaptor protein 2	2696	0.25
chr20_821090_821241	0.21	FAM110A	family with sequence similarity 110, member A	4120	0.27
chr15_38854702_38854853	0.21	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	2059	0.32
chr1_45769094_45769262	0.21	HPDL	4-hydroxyphenylpyruvate dioxygenase-like	23367	0.14
chrX_129225529_129225680	0.21	ELF4	E74-like factor 4 (ets domain transcription factor)	18732	0.19
chr22_41033042_41033281	0.21	MKL1	megakaryoblastic leukemia (translocation) 1	466	0.84
chr4_89534455_89534711	0.21	HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	7638	0.19
chr21_34776986_34777191	0.21	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	1316	0.43
chr22_31139652_31139831	0.21	ENSG00000264661	.	12197	0.17
chr1_28879171_28879359	0.20	TRNAU1AP	tRNA selenocysteine 1 associated protein 1	332	0.8
chr19_6425167_6425318	0.20	KHSRP	KH-type splicing regulatory protein	437	0.66
chr10_73529493_73529671	0.20	C10orf54	chromosome 10 open reading frame 54	3673	0.23
chr15_34609507_34609658	0.20	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	1398	0.29
chr12_47611625_47611801	0.20	PCED1B	PC-esterase domain containing 1B	1332	0.49
chr15_75230580_75230787	0.20	COX5A	cytochrome c oxidase subunit Va	174	0.92
chrX_123096191_123096863	0.20	STAG2	stromal antigen 2	493	0.85
chr17_76771796_76772004	0.20	CYTH1	cytohesin 1	6454	0.2
chr21_46300234_46300404	0.20	PTTG1IP	pituitary tumor-transforming 1 interacting protein	6567	0.13
chr1_212461608_212461798	0.20	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	2824	0.24
chr19_10706452_10706725	0.20	SLC44A2	solute carrier family 44 (choline transporter), member 2	6545	0.1
chr15_93458767_93458918	0.20	CHD2	chromodomain helicase DNA binding protein 2	11139	0.19
chr11_60213804_60213975	0.20	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	9336	0.16
chr4_39429086_39429237	0.20	ENSG00000238797	.	14124	0.11
chr19_54875923_54876565	0.20	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	170	0.91
chr1_231666043_231666200	0.20	TSNAX	translin-associated factor X	1720	0.31
chr6_34283894_34284092	0.20	C6orf1	chromosome 6 open reading frame 1	66746	0.09
chr14_77330807_77330958	0.20	ENSG00000223174	.	25724	0.16
chr16_84603491_84603642	0.20	TLDC1	TBC/LysM-associated domain containing 1	15927	0.16
chr4_1195622_1195773	0.20	SPON2	spondin 2, extracellular matrix protein	3179	0.18
chrX_8150685_8150836	0.20	VCX2	variable charge, X-linked 2	11452	0.28
chr7_99070141_99070303	0.20	ZNF789	zinc finger protein 789	242	0.83
chr2_190442967_190443214	0.20	SLC40A1	solute carrier family 40 (iron-regulated transporter), member 1	2523	0.35
chr15_80262648_80263745	0.20	BCL2A1	BCL2-related protein A1	315	0.89
chr2_37762882_37763076	0.20	AC006369.2		64300	0.12
chr20_2311261_2311412	0.19	TGM3	transglutaminase 3	34689	0.16
chr12_58230016_58230207	0.19	RP11-620J15.1		764	0.44
chr2_223290336_223290619	0.19	SGPP2	sphingosine-1-phosphate phosphatase 2	1241	0.5
chr11_118213153_118213331	0.19	CD3D	CD3d molecule, delta (CD3-TCR complex)	104	0.93
chr12_124155262_124155441	0.19	TCTN2	tectonic family member 2	309	0.86
chr21_36420108_36421159	0.19	RUNX1	runt-related transcription factor 1	829	0.77
chr19_46179944_46180134	0.19	ENSG00000207773	.	1853	0.16
chr17_45570068_45570247	0.19	MRPL45P2	mitochondrial ribosomal protein L45 pseudogene 2	332	0.88
chr1_243430515_243430666	0.19	SDCCAG8	serologically defined colon cancer antigen 8	11218	0.19
chr2_136504991_136505142	0.19	UBXN4	UBX domain protein 4	5762	0.21
chr12_94517592_94517768	0.19	PLXNC1	plexin C1	24819	0.2
chr1_22351357_22351739	0.19	ENSG00000201273	.	14070	0.09
chr21_47035540_47035741	0.19	PCBP3	poly(rC) binding protein 3	27968	0.2
chr12_132469658_132469809	0.19	ENSG00000271905	.	16587	0.15
chr13_40397451_40397602	0.19	ENSG00000212553	.	33838	0.19
chr7_76828015_76828166	0.19	FGL2	fibrinogen-like 2	1053	0.59
chrX_109708973_109709124	0.19	RGAG1	retrotransposon gag domain containing 1	15255	0.23
chr6_53209536_53209824	0.19	ELOVL5	ELOVL fatty acid elongase 5	3907	0.26
chr17_56419518_56419935	0.19	BZRAP1-AS1	BZRAP1 antisense RNA 1	5007	0.12
chr8_65607910_65608061	0.19	RP11-1D12.1		39031	0.2
chr12_65058254_65058405	0.19	RP11-338E21.3		9530	0.14
chr19_59055180_59055577	0.19	TRIM28	tripartite motif containing 28	80	0.82
chr17_78991849_78992000	0.19	AC127496.1	Uncharacterized protein	14789	0.11
chr14_81629657_81629808	0.18	RP11-114N19.3		7026	0.24
chr12_40012002_40012194	0.18	ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	1455	0.48
chr4_185741986_185742137	0.18	ACSL1	acyl-CoA synthetase long-chain family member 1	5127	0.2
chr10_120891057_120891670	0.18	FAM45A	family with sequence similarity 45, member A	27734	0.11
chr1_212927626_212927881	0.18	NSL1	NSL1, MIS12 kinetochore complex component	37170	0.12
chr1_154581072_154581232	0.18	ADAR	adenosine deaminase, RNA-specific	470	0.73
chr1_155946704_155947008	0.18	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	1095	0.29
chr1_147994918_147995202	0.18	ENSG00000212456	.	914	0.59
chr17_18966559_18966712	0.18	ENSG00000262074	.	814	0.4
chr2_175456985_175457136	0.18	WIPF1	WAS/WASL interacting protein family, member 1	5433	0.19
chrY_21906454_21906814	0.18	KDM5D	lysine (K)-specific demethylase 5D	13	0.99
chr2_220117396_220117589	0.18	TUBA4A	tubulin, alpha 4a	223	0.82
chr14_32366460_32366611	0.18	RP11-187E13.1	Uncharacterized protein	47524	0.17
chr21_35885755_35885906	0.18	KCNE1	potassium voltage-gated channel, Isk-related family, member 1	1257	0.46
chr19_4975873_4976024	0.18	KDM4B	lysine (K)-specific demethylase 4B	6805	0.19
chr10_64915626_64915777	0.18	NRBF2	nuclear receptor binding factor 2	22616	0.18
chr1_148766073_148766315	0.18	ENSG00000206968	.	908	0.66

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1	0.1	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618)
0.1	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.2	GO:0051138	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.4	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.3	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.2	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.3	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0072239	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0	0.3	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.2	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.2	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0016139	glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0	0.2	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.2	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0032418	lysosome localization(GO:0032418)
0.0	0.1	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.1	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.5	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.3	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.5	GO:0050798	activated T cell proliferation(GO:0050798)
0.0	0.1	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.2	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.2	GO:0007080	mitotic metaphase plate congression(GO:0007080)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0072698	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.1	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.2	GO:0009650	UV protection(GO:0009650)
0.0	0.3	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.5	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.0	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.2	GO:0060736	prostate gland growth(GO:0060736)
0.0	0.1	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.3	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.1	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.2	GO:0071230	cellular response to amino acid stimulus(GO:0071230)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.2	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0006743	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.2	GO:0006044	N-acetylglucosamine metabolic process(GO:0006044)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.1	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.0	0.1	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.0	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.0	GO:0045586	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0	0.0	GO:0046606	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.0	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0007141	male meiosis I(GO:0007141)
0.0	0.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.0	GO:0070266	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.0	GO:0070933	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.0	GO:0009173	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.0	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.0	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.0	0.1	GO:0032770	positive regulation of monooxygenase activity(GO:0032770)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.0	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.0	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:0090201	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	0.0	GO:0046549	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.0	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.1	GO:0032372	negative regulation of sterol transport(GO:0032372) negative regulation of cholesterol transport(GO:0032375)
0.0	0.2	GO:0051225	spindle assembly(GO:0051225)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0032715	negative regulation of interleukin-6 production(GO:0032715)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.0	GO:0034379	very-low-density lipoprotein particle assembly(GO:0034379)
0.0	0.0	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.0	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.0	GO:0008216	spermidine metabolic process(GO:0008216)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.2	GO:0070552	BRISC complex(GO:0070552)
0.1	0.4	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.5	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.2	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.2	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.2	GO:0030897	HOPS complex(GO:0030897)
0.0	0.1	GO:0071817	MMXD complex(GO:0071817)
0.0	0.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.2	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.2	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.3	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.2	GO:0001673	male germ cell nucleus(GO:0001673)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.0	GO:0002139	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.0	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.0	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.2	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0070652	HAUS complex(GO:0070652)
0.0	0.2	GO:0005669	transcription factor TFIID complex(GO:0005669)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	0.3	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.2	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.3	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.4	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.0	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.2	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.2	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.4	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0043139	5'-3' DNA helicase activity(GO:0043139)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.5	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.2	GO:0045309	protein phosphorylated amino acid binding(GO:0045309)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0010340	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0	0.1	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.5	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.3	GO:0016675	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.0	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.3	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.1	GO:0016530	metallochaperone activity(GO:0016530)
0.0	0.2	GO:0019200	carbohydrate kinase activity(GO:0019200)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.2	GO:0016251	obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	0.1	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.1	GO:0017069	snRNA binding(GO:0017069)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.0	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0036041	long-chain fatty acid binding(GO:0036041)
0.0	0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
1.0	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.4	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3	PID S1P S1P1 PATHWAY	S1P1 pathway
0.5	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.4	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.2	PID TRAIL PATHWAY	TRAIL signaling pathway
0.2	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.4	PID ATM PATHWAY	ATM pathway
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.3	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.3	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.2	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	PID MYC PATHWAY	C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SIGNALING BY FGFR IN DISEASE	Genes involved in Signaling by FGFR in disease
0.0	0.4	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.5	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.3	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.1	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.1	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.0	0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.3	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.9	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.2	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.2	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.6	REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	Genes involved in RNA Polymerase II Pre-transcription Events
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.2	REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.0	0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.1	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.4	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling