Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PKNOX1_TGIF2

Z-value: 0.92

Motif logo

Transcription factors associated with PKNOX1_TGIF2

Gene Symbol	Gene ID	Gene Info
PKNOX1 Ensembl NCBI GeneCards UniProt	ENSG00000160199.10	PKNOX1
TGIF2 Ensembl NCBI GeneCards UniProt	ENSG00000118707.5	TGIF2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PKNOX1	chr21_44395763_44396208	1234	0.425688	0.23	5.4e-01	Click!
PKNOX1	chr21_44394961_44395127	293	0.888993	0.18	6.4e-01	Click!
PKNOX1	chr21_44395511_44395752	880	0.556819	0.01	9.8e-01	Click!
PKNOX1	chr21_44393727_44394254	630	0.687024	-0.00	9.9e-01	Click!
TGIF2	chr20_35202977_35203807	317	0.552898	0.40	2.9e-01	Click!
TGIF2	chr20_35201957_35202480	208	0.648461	0.30	4.3e-01	Click!
TGIF2	chr20_35203812_35203967	814	0.358401	0.25	5.2e-01	Click!
TGIF2	chr20_35204810_35204961	1810	0.204835	-0.09	8.3e-01	Click!

Activity of the PKNOX1_TGIF2 motif across conditions

Conditions sorted by the z-value of the PKNOX1_TGIF2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_50144599_50144750	0.39	RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	3215	0.28
chr19_1856469_1856846	0.39	CTB-31O20.8		3592	0.1
chrX_78621891_78622920	0.38	ITM2A	integral membrane protein 2A	451	0.91
chr17_17726041_17726867	0.37	SREBF1	sterol regulatory element binding transcription factor 1	478	0.73
chr7_104908860_104909472	0.37	SRPK2	SRSF protein kinase 2	296	0.92
chr8_60028293_60029059	0.36	RP11-25K19.1		2923	0.25
chr1_193154702_193155811	0.36	B3GALT2	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2	528	0.8
chr9_33446798_33447442	0.35	AQP3	aquaporin 3 (Gill blood group)	489	0.76
chr20_39677452_39677945	0.34	TOP1	topoisomerase (DNA) I	20240	0.19
chr3_132349108_132349259	0.34	UBA5	ubiquitin-like modifier activating enzyme 5	24107	0.16
chr20_58512577_58512765	0.33	PPP1R3D	protein phosphatase 1, regulatory subunit 3D	2681	0.21
chr4_157692249_157692489	0.33	RP11-154F14.2		70142	0.11
chr4_30725920_30726277	0.33	PCDH7	protocadherin 7	2121	0.46
chr21_35305075_35305226	0.33	LINC00649	long intergenic non-protein coding RNA 649	1632	0.32
chr6_64972397_64972548	0.31	RP11-349P19.1		115216	0.07
chr1_19278015_19278216	0.31	IFFO2	intermediate filament family orphan 2	4077	0.23
chr5_146257425_146257826	0.31	PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	580	0.82
chr11_46581548_46581763	0.31	AMBRA1	autophagy/beclin-1 regulator 1	31259	0.15
chr10_99442034_99442185	0.30	AVPI1	arginine vasopressin-induced 1	4971	0.16
chr17_64464860_64465690	0.29	RP11-4F22.2		52303	0.15
chr9_33447649_33448227	0.29	AQP3	aquaporin 3 (Gill blood group)	329	0.86
chr1_78468921_78469158	0.29	RP11-386I14.4		1199	0.35
chr13_22956879_22957030	0.29	ENSG00000253094	.	420330	0.01
chr6_82732214_82732365	0.29	ENSG00000223044	.	187868	0.03
chr18_55930027_55930178	0.28	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	41299	0.16
chr2_161994699_161994850	0.28	TANK	TRAF family member-associated NFKB activator	1308	0.52
chr3_31575511_31576107	0.27	STT3B	STT3B, subunit of the oligosaccharyltransferase complex (catalytic)	1527	0.55
chr13_28494142_28494415	0.27	PDX1	pancreatic and duodenal homeobox 1	121	0.93
chr4_54244645_54244895	0.27	FIP1L1	factor interacting with PAPOLA and CPSF1	764	0.7
chr1_108584009_108584286	0.26	ENSG00000264753	.	22754	0.22
chr22_25508803_25509083	0.26	CTA-221G9.11		284	0.93
chr16_27413508_27414237	0.26	IL21R	interleukin 21 receptor	377	0.88
chr12_54891563_54891796	0.26	NCKAP1L	NCK-associated protein 1-like	184	0.93
chr3_15482302_15482608	0.26	EAF1-AS1	EAF1 antisense RNA 1	354	0.48
chr17_18949450_18949786	0.25	GRAP	GRB2-related adaptor protein	692	0.54
chr14_93674231_93674490	0.25	UBR7	ubiquitin protein ligase E3 component n-recognin 7 (putative)	721	0.44
chr17_63060035_63060186	0.25	GNA13	guanine nucleotide binding protein (G protein), alpha 13	7153	0.19
chrX_72434024_72434767	0.25	NAP1L2	nucleosome assembly protein 1-like 2	273	0.94
chr19_42636826_42637026	0.25	CTC-378H22.1		219	0.52
chr18_54318050_54319471	0.25	TXNL1	thioredoxin-like 1	64	0.61
chr17_19031223_19031746	0.25	GRAPL	GRB2-related adaptor protein-like	636	0.51
chr10_54759512_54759663	0.24	ENSG00000201196	.	147220	0.05
chr16_30710458_30711178	0.24	SRCAP	Snf2-related CREBBP activator protein	356	0.48
chr17_74749100_74749251	0.24	ENSG00000200257	.	181	0.89
chr2_99955142_99955293	0.24	EIF5B	eukaryotic translation initiation factor 5B	1401	0.34
chr7_142425930_142426124	0.24	PRSS1	protease, serine, 1 (trypsin 1)	31292	0.16
chr21_45660106_45660362	0.24	ICOSLG	inducible T-cell co-stimulator ligand	489	0.69
chr1_26453661_26453812	0.24	PDIK1L	PDLIM1 interacting kinase 1 like	15396	0.1
chr1_185529229_185529380	0.24	ENSG00000207108	.	70356	0.11
chr9_92111480_92111784	0.24	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	715	0.59
chr11_64013126_64013464	0.24	PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B	7	0.62
chr1_40851828_40852273	0.24	SMAP2	small ArfGAP2	10457	0.17
chr1_161195725_161196723	0.23	TOMM40L	translocase of outer mitochondrial membrane 40 homolog (yeast)-like	130	0.84
chr18_28779454_28779605	0.23	DSC1	desmocollin 1	36710	0.15
chr1_208417858_208418217	0.23	PLXNA2	plexin A2	372	0.93
chr5_162930555_162931177	0.23	MAT2B	methionine adenosyltransferase II, beta	746	0.62
chr6_90896871_90897022	0.23	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	109515	0.06
chr18_18823015_18823269	0.23	GREB1L	growth regulation by estrogen in breast cancer-like	823	0.71
chr16_85673169_85673320	0.23	GSE1	Gse1 coiled-coil protein	14794	0.16
chr6_149386973_149387124	0.23	RP11-162J8.3		33339	0.2
chr6_27858007_27858288	0.23	HIST1H3J	histone cluster 1, H3j	423	0.61
chr10_35089896_35090047	0.23	PARD3	par-3 family cell polarity regulator	14278	0.22
chr9_18569385_18569536	0.22	ENSG00000264638	.	3844	0.33
chr20_48989399_48989550	0.22	ENSG00000244376	.	56546	0.13
chr1_17379619_17379770	0.22	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	971	0.54
chr2_4455409_4455560	0.22	ENSG00000215960	.	179376	0.03
chr1_228362327_228362478	0.22	IBA57	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)	151	0.92
chr7_75933552_75933703	0.22	HSPB1	heat shock 27kDa protein 1	733	0.62
chr1_16122451_16122602	0.22	FBLIM1	filamin binding LIM protein 1	31078	0.1
chr1_121159703_121159854	0.22	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	223841	0.02
chr6_139868311_139868622	0.22	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	172709	0.03
chr20_33867276_33867427	0.22	RP4-614O4.11		495	0.56
chr18_53296660_53296811	0.21	TCF4	transcription factor 4	1858	0.49
chr8_23145924_23146455	0.21	R3HCC1	R3H domain and coiled-coil containing 1	254	0.9
chr13_30528667_30528971	0.21	LINC00572	long intergenic non-protein coding RNA 572	28031	0.25
chr6_167536422_167536640	0.21	CCR6	chemokine (C-C motif) receptor 6	272	0.91
chr1_205462241_205462485	0.21	CDK18	cyclin-dependent kinase 18	11360	0.17
chr9_126234353_126234504	0.21	RP11-230L22.4		19735	0.22
chr18_22911937_22912088	0.21	ZNF521	zinc finger protein 521	19145	0.24
chr22_18640172_18640391	0.21	USP18	ubiquitin specific peptidase 18	7615	0.17
chr6_128580481_128581088	0.21	PTPRK	protein tyrosine phosphatase, receptor type, K	62542	0.14
chr15_80354539_80354690	0.21	ZFAND6	zinc finger, AN1-type domain 6	1848	0.41
chr1_22463869_22464020	0.20	WNT4	wingless-type MMTV integration site family, member 4	5515	0.23
chr12_89855825_89855993	0.20	POC1B	POC1 centriolar protein B	35125	0.15
chr10_73532392_73533248	0.20	C10orf54	chromosome 10 open reading frame 54	435	0.83
chr15_33300884_33301035	0.20	ENSG00000212415	.	38031	0.18
chr8_68514800_68514982	0.20	ENSG00000221660	.	108976	0.07
chr15_36872415_36872566	0.20	C15orf41	chromosome 15 open reading frame 41	441	0.9
chr2_11887384_11888228	0.20	LPIN1	lipin 1	1042	0.41
chr15_40532008_40532159	0.20	PAK6	p21 protein (Cdc42/Rac)-activated kinase 6	12	0.96
chr1_72470618_72470769	0.20	NEGR1	neuronal growth regulator 1	95920	0.09
chr1_201290547_201290698	0.20	PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	37791	0.13
chr4_52708225_52709084	0.20	DCUN1D4	DCN1, defective in cullin neddylation 1, domain containing 4	575	0.86
chr3_16522365_16522516	0.19	RFTN1	raftlin, lipid raft linker 1	1932	0.44
chr18_32660928_32661079	0.19	MAPRE2	microtubule-associated protein, RP/EB family, member 2	39389	0.2
chr17_38803171_38803349	0.19	SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	633	0.63
chr14_22988565_22988896	0.19	TRAJ15	T cell receptor alpha joining 15	9850	0.11
chr7_29233941_29234476	0.19	CHN2	chimerin 2	87	0.9
chr20_56275354_56275505	0.19	PMEPA1	prostate transmembrane protein, androgen induced 1	8543	0.26
chr10_25869445_25869596	0.19	ENSG00000222543	.	186747	0.03
chr10_134261699_134261957	0.19	C10orf91	chromosome 10 open reading frame 91	3135	0.24
chr17_40274740_40274891	0.19	HSPB9	heat shock protein, alpha-crystallin-related, B9	59	0.94
chr19_34717882_34718033	0.19	KIAA0355	KIAA0355	27485	0.19
chr1_208418253_208418520	0.19	PLXNA2	plexin A2	721	0.82
chr2_204801338_204802214	0.19	ICOS	inducible T-cell co-stimulator	273	0.95
chr14_100842881_100843420	0.19	WARS	tryptophanyl-tRNA synthetase	8	0.78
chr5_40685855_40686084	0.19	PTGER4	prostaglandin E receptor 4 (subtype EP4)	6369	0.22
chr4_78743157_78743308	0.19	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	2463	0.37
chr5_176237821_176238145	0.19	UNC5A	unc-5 homolog A (C. elegans)	505	0.84
chr17_72756037_72756203	0.19	SLC9A3R1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	2022	0.18
chr6_106961305_106961653	0.19	AIM1	absent in melanoma 1	1749	0.38
chr8_26249046_26249197	0.19	BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	1243	0.5
chr2_129365909_129366162	0.19	ENSG00000238379	.	163263	0.04
chr17_4762663_4762814	0.18	ENSG00000263599	.	16183	0.08
chr6_13761461_13761614	0.18	MCUR1	mitochondrial calcium uniporter regulator 1	40040	0.15
chr1_117910944_117911674	0.18	MAN1A2	mannosidase, alpha, class 1A, member 2	1238	0.61
chr8_119452205_119452425	0.18	SAMD12	sterile alpha motif domain containing 12	140806	0.05
chr12_92440588_92440837	0.18	C12orf79	chromosome 12 open reading frame 79	90085	0.08
chr8_59718017_59718168	0.18	ENSG00000201231	.	9019	0.29
chr22_27441616_27441767	0.18	ENSG00000200443	.	9841	0.32
chr12_14525729_14525880	0.18	ATF7IP	activating transcription factor 7 interacting protein	5497	0.26
chr15_71300550_71300701	0.18	LRRC49	leucine rich repeat containing 49	71751	0.1
chr1_27028870_27029082	0.18	ARID1A	AT rich interactive domain 1A (SWI-like)	6081	0.16
chr1_215020458_215020609	0.18	KCNK2	potassium channel, subfamily K, member 2	158665	0.04
chr4_34195647_34195839	0.18	ENSG00000263814	.	192716	0.03
chr22_31335429_31335580	0.18	MORC2	MORC family CW-type zinc finger 2	6623	0.16
chr7_45614612_45614823	0.18	ADCY1	adenylate cyclase 1 (brain)	596	0.84
chr5_139283271_139283734	0.18	NRG2	neuregulin 2	480	0.84
chr4_83956375_83957237	0.18	COPS4	COP9 signalosome subunit 4	428	0.82
chr1_4606573_4606724	0.18	AJAP1	adherens junctions associated protein 1	108144	0.08
chr16_89381066_89381217	0.18	AC137932.6		6400	0.14
chr2_229949087_229949238	0.18	PID1	phosphotyrosine interaction domain containing 1	147639	0.05
chr1_17541747_17541898	0.18	PADI1	peptidyl arginine deiminase, type I	10201	0.17
chr8_129005826_129005977	0.18	ENSG00000207110	.	5476	0.19
chr1_6453925_6454377	0.17	ACOT7	acyl-CoA thioesterase 7	300	0.65
chr11_77062251_77062402	0.17	PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	1994	0.4
chr2_23736447_23736598	0.17	AC011239.1	Uncharacterized protein	10692	0.3
chr1_9653728_9653879	0.17	TMEM201	transmembrane protein 201	3152	0.26
chr19_31830955_31831409	0.17	AC007796.1		8605	0.25
chr7_48675933_48676084	0.17	ABCA13	ATP-binding cassette, sub-family A (ABC1), member 13	128540	0.06
chr19_42626071_42626364	0.17	POU2F2	POU class 2 homeobox 2	515	0.63
chr17_16944854_16945024	0.17	MPRIP	myosin phosphatase Rho interacting protein	920	0.58
chr11_59473933_59474084	0.17	ENSG00000223223	.	152	0.93
chr7_127023381_127023532	0.17	ZNF800	zinc finger protein 800	8716	0.24
chr19_54676940_54677234	0.17	TMC4	transmembrane channel-like 4	143	0.89
chr14_56662445_56662672	0.17	PELI2	pellino E3 ubiquitin protein ligase family member 2	76731	0.11
chr12_118455272_118455463	0.17	RFC5	replication factor C (activator 1) 5, 36.5kDa	833	0.64
chr18_13567514_13567726	0.17	RP11-53B2.4		2586	0.2
chr16_56945671_56945822	0.17	HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	20214	0.11
chr18_30049396_30050442	0.17	GAREM	GRB2 associated, regulator of MAPK1	476	0.87
chr11_9272154_9272305	0.17	RP11-5L12.1		5173	0.21
chr3_58012091_58012242	0.17	FLNB	filamin B, beta	18039	0.25
chr11_62321822_62322177	0.17	AHNAK	AHNAK nucleoprotein	1708	0.18
chr11_44588275_44588433	0.16	CD82	CD82 molecule	1081	0.58
chr7_115850994_115851250	0.16	TES	testis derived transcript (3 LIM domains)	519	0.82
chr9_100748941_100749092	0.16	RP11-535C21.3		922	0.5
chr2_96812420_96812577	0.16	DUSP2	dual specificity phosphatase 2	1319	0.38
chr3_107317640_107318380	0.16	BBX	bobby sox homolog (Drosophila)	150	0.98
chr11_69079389_69079561	0.16	MYEOV	myeloma overexpressed	17850	0.27
chrX_118071502_118071653	0.16	LONRF3	LON peptidase N-terminal domain and ring finger 3	37004	0.2
chr16_88490951_88491102	0.16	ZNF469	zinc finger protein 469	2853	0.26
chr3_182983612_182983806	0.16	B3GNT5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	577	0.77
chr13_30267514_30267665	0.16	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	97764	0.08
chr19_30792538_30792689	0.16	ZNF536	zinc finger protein 536	70706	0.12
chr20_43150070_43150299	0.16	SERINC3	serine incorporator 3	467	0.76
chrX_22153236_22153476	0.16	PHEX	phosphate regulating endopeptidase homolog, X-linked	37534	0.16
chr16_57831320_57831471	0.16	KIFC3	kinesin family member C3	281	0.88
chr20_47757335_47757486	0.16	STAU1	staufen double-stranded RNA binding protein 1	33390	0.16
chr2_86114637_86114901	0.16	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	97	0.97
chr12_51015115_51015266	0.16	ENSG00000207136	.	11866	0.21
chr17_8907022_8907441	0.16	NTN1	netrin 1	17628	0.22
chr2_175197056_175197207	0.16	SP9	Sp9 transcription factor	2543	0.24
chr16_31076129_31076313	0.16	ZNF668	zinc finger protein 668	69	0.86
chr2_64441847_64441998	0.16	AC074289.1		7813	0.27
chr20_39786785_39786936	0.16	RP1-1J6.2		20217	0.18
chr5_153416653_153416804	0.16	FAM114A2	family with sequence similarity 114, member A2	142	0.95
chr4_40517752_40517903	0.16	RBM47	RNA binding motif protein 47	163	0.96
chrX_130020204_130020367	0.16	ENOX2	ecto-NOX disulfide-thiol exchanger 2	16893	0.28
chr8_62621050_62621416	0.16	ASPH	aspartate beta-hydroxylase	5851	0.24
chr12_53781982_53782414	0.16	SP1	Sp1 transcription factor	7112	0.13
chr10_126314631_126314782	0.16	FAM53B-AS1	FAM53B antisense RNA 1	77488	0.09
chr1_156785141_156785328	0.16	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	214	0.87
chr13_103251895_103252050	0.16	TPP2	tripeptidyl peptidase II	2599	0.29
chr4_31171719_31171870	0.16	RP11-619J20.1		376202	0.01
chr11_1909549_1909755	0.16	C11orf89	chromosome 11 open reading frame 89	2432	0.16
chr9_43133207_43133798	0.16	ANKRD20A3	ankyrin repeat domain 20 family, member A3	42	0.97
chr1_36173086_36173270	0.16	ENSG00000239859	.	1303	0.39
chr8_143443109_143443260	0.16	TSNARE1	t-SNARE domain containing 1	7060	0.23
chr21_36562046_36562197	0.16	RUNX1	runt-related transcription factor 1	140480	0.05
chr18_11487781_11487932	0.15	NPIPB1P	nuclear pore complex interacting protein family, member B1, pseudogene	151604	0.04
chr17_3289151_3289302	0.15	RP11-64J4.2		361	0.82
chr4_1228146_1228426	0.15	CTBP1	C-terminal binding protein 1	6214	0.15
chr18_68267310_68267461	0.15	GTSCR1	Gilles de la Tourette syndrome chromosome region, candidate 1	50562	0.17
chr5_112824477_112824726	0.15	MCC	mutated in colorectal cancers	74	0.97
chr2_131798149_131798300	0.15	ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	626	0.76
chr1_67893569_67893720	0.15	SERBP1	SERPINE1 mRNA binding protein 1	2411	0.31
chr8_1791296_1791447	0.15	ARHGEF10	Rho guanine nucleotide exchange factor (GEF) 10	17094	0.2
chr10_104420612_104420763	0.15	TRIM8	tripartite motif containing 8	16043	0.16
chr9_18689231_18689382	0.15	ENSG00000252960	.	38161	0.2
chr3_150059920_150060071	0.15	TSC22D2	TSC22 domain family, member 2	66127	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX1_TGIF2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0070295	renal water absorption(GO:0070295)
0.1	0.4	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1	0.3	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.1	0.3	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1	0.4	GO:0021535	cell migration in hindbrain(GO:0021535)
0.1	0.2	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.1	0.2	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.1	0.2	GO:0051832	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0032641	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:2000794	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.2	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.3	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.2	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.1	GO:0060197	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0046880	regulation of follicle-stimulating hormone secretion(GO:0046880)
0.0	0.2	GO:0006337	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0033261	obsolete regulation of S phase(GO:0033261)
0.0	0.0	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.0	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.2	GO:0007616	long-term memory(GO:0007616)
0.0	0.1	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.1	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.0	GO:0042482	positive regulation of odontogenesis(GO:0042482)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.2	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:0045217	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.1	GO:0018216	peptidyl-arginine methylation(GO:0018216)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.0	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.1	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.1	GO:0000090	mitotic anaphase(GO:0000090)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.0	GO:0048711	positive regulation of astrocyte differentiation(GO:0048711)
0.0	0.1	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.0	GO:0070293	renal absorption(GO:0070293)
0.0	0.0	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.0	GO:0032351	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0021799	cerebral cortex radially oriented cell migration(GO:0021799)
0.0	0.0	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.1	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.0	0.3	GO:0009267	cellular response to starvation(GO:0009267)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.5	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.1	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.0	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0045607	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.0	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.1	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.0	GO:0071883	adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.0	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.1	GO:0001706	endoderm formation(GO:0001706)
0.0	0.1	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.0	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0090598	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.2	GO:0009067	aspartate family amino acid biosynthetic process(GO:0009067)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.0	GO:1901722	regulation of cell proliferation involved in kidney development(GO:1901722)
0.0	0.2	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.0	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.0	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.0	GO:0040023	establishment of nucleus localization(GO:0040023)
0.0	0.1	GO:0006972	hyperosmotic response(GO:0006972)
0.0	0.0	GO:0021571	rhombomere 5 development(GO:0021571)
0.0	0.1	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.0	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0006105	succinate metabolic process(GO:0006105)
0.0	0.0	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.0	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.0	GO:2000095	regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.3	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.1	GO:0045257	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.2	GO:0071564	npBAF complex(GO:0071564)
0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	GO:0002141	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.1	GO:0033270	paranode region of axon(GO:0033270)
0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.3	GO:0001772	immunological synapse(GO:0001772)
0.1	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.1	GO:0042599	lamellar body(GO:0042599)
0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.1	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	GO:0008180	COP9 signalosome(GO:0008180)
0.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0008091	spectrin(GO:0008091)
0.1	GO:0005652	nuclear lamina(GO:0005652)
0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.2	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.1	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.2	GO:0046930	pore complex(GO:0046930)
0.1	GO:0005915	zonula adherens(GO:0005915)
0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	GO:0034451	centriolar satellite(GO:0034451)
0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0015254	glycerol channel activity(GO:0015254)
0.1	0.2	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.3	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.2	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.2	GO:0016273	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.2	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.4	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.0	GO:0051380	norepinephrine binding(GO:0051380)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.1	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.0	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.0	GO:0016307	phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.0	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.0	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.0	GO:0051379	alpha2-adrenergic receptor activity(GO:0004938) epinephrine binding(GO:0051379)
0.0	0.0	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.0	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.0	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.2	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.1	GO:0033549	MAP kinase phosphatase activity(GO:0033549)
0.0	0.0	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.0	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.4	GO:0001067	regulatory region DNA binding(GO:0000975) regulatory region nucleic acid binding(GO:0001067) transcription regulatory region DNA binding(GO:0044212)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.4	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.5	PID ATR PATHWAY	ATR signaling pathway
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	PID S1P S1P4 PATHWAY	S1P4 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.4	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.1	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.3	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.2	REACTOME PROLONGED ERK ACTIVATION EVENTS	Genes involved in Prolonged ERK activation events
0.0	0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.1	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated