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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for PKNOX2

Z-value: 1.06

Motif logo

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Transcription factors associated with PKNOX2

Gene Symbol Gene ID Gene Info
PKNOX2
ENSG00000165495.11 PBX/knotted 1 homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr11_125035186_125035397PKNOX26410.4747960.599.3e-02Click!
chr11_125039995_125040154PKNOX254240.1667720.571.1e-01Click!
chr11_125036574_125036725PKNOX219990.2448570.541.3e-01Click!
chr11_125036127_125036278PKNOX215520.2861290.511.6e-01Click!
chr11_125035763_125035964PKNOX212130.3347600.481.9e-01Click!

Activity of the PKNOX2 motif across conditions

Conditions sorted by the z-value of the PKNOX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_65530319_65530470 0.48 ENSG00000199135
 .
 6203
 0.2
chr1_66258257_66258503 0.44 PDE4B
 phosphodiesterase 4B, cAMP-specific
 183
 0.96
chrX_100334236_100334411 0.43 TMEM35
 transmembrane protein 35
 614
 0.68
chr9_19128575_19128726 0.40 PLIN2
 perilipin 2
 1076
 0.44
chr6_5498765_5499077 0.39 RP1-232P20.1
40613
 0.2
chr5_67577155_67577306 0.38 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 1095
 0.66
chr5_56112470_56113088 0.38 MAP3K1
 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
 1378
 0.44
chr16_68693087_68693238 0.37 RP11-615I2.2
13091
 0.13
chr1_21859764_21859915 0.36 ALPL
 alkaline phosphatase, liver/bone/kidney
 17933
 0.19
chr19_49121963_49122114 0.36 RPL18
 ribosomal protein L18
 346
 0.53
chr6_82732214_82732365 0.35 ENSG00000223044
 .
 187868
 0.03
chr1_95389567_95389941 0.34 CNN3
 calponin 3, acidic
 1583
 0.36
chr11_3043840_3044115 0.34 CARS-AS1
 CARS antisense RNA 1
 6647
 0.13
chr14_30054222_30054373 0.33 PRKD1
 protein kinase D1
 49383
 0.15
chr12_90272914_90273065 0.33 ENSG00000252823
 .
 125153
 0.06
chr16_89381066_89381217 0.33 AC137932.6
6400
 0.14
chr5_157714663_157714814 0.32 ENSG00000222626
 .
 310774
 0.01
chr2_47401669_47401853 0.31 CALM2
 calmodulin 2 (phosphorylase kinase, delta)
 1889
 0.37
chr20_47894397_47894608 0.31 ZNFX1
 zinc finger, NFX1-type containing 1
 76
 0.67
chr6_24910150_24910301 0.30 FAM65B
 family with sequence similarity 65, member B
 970
 0.62
chr1_109740352_109740715 0.30 ENSG00000238310
 .
 9937
 0.15
chr12_92440588_92440837 0.30 C12orf79
 chromosome 12 open reading frame 79
 90085
 0.08
chr14_92331424_92331867 0.30 TC2N
 tandem C2 domains, nuclear
 2228
 0.32
chr22_23282661_23282812 0.30 IGLJ7
 immunoglobulin lambda joining 7
 19174
 0.07
chr20_8380586_8380742 0.30 PLCB1-IT1
 PLCB1 intronic transcript 1 (non-protein coding)
 151292
 0.04
chr5_163147994_163148145 0.29 ENSG00000251998
 .
 75102
 0.12
chrX_100352542_100352928 0.29 CENPI
 centromere protein I
 443
 0.78
chr6_131255225_131255376 0.29 EPB41L2
 erythrocyte membrane protein band 4.1-like 2
 22325
 0.27
chr4_3529804_3529955 0.29 LRPAP1
 low density lipoprotein receptor-related protein associated protein 1
 4407
 0.19
chr7_99516388_99516774 0.28 TRIM4
 tripartite motif containing 4
 147
 0.91
chr4_141217305_141217524 0.28 ENSG00000252300
 .
 21148
 0.19
chr13_53419960_53420114 0.28 PCDH8
 protocadherin 8
 2603
 0.34
chr4_139813437_139813623 0.28 RP11-371F15.3
45605
 0.16
chr3_50298349_50298500 0.28 SEMA3B-AS1
 SEMA3B antisense RNA 1 (head to head)
 6379
 0.09
chr1_33804639_33805031 0.28 ENSG00000222112
 .
 2370
 0.19
chr6_82854353_82854866 0.27 ENSG00000223044
 .
 65548
 0.14
chr6_162052389_162052540 0.27 ENSG00000221021
 .
 16366
 0.31
chr19_46171409_46171560 0.27 GIPR
 gastric inhibitory polypeptide receptor
 18
 0.94
chr11_111741428_111741733 0.26 ALG9
 ALG9, alpha-1,2-mannosyltransferase
 8
 0.96
chr5_32175143_32175294 0.26 GOLPH3
 golgi phosphoprotein 3 (coat-protein)
 762
 0.67
chr4_178324604_178324755 0.25 AGA
 aspartylglucosaminidase
 36099
 0.14
chr8_37728655_37728889 0.25 RAB11FIP1
 RAB11 family interacting protein 1 (class I)
 6863
 0.15
chr1_117910944_117911674 0.25 MAN1A2
 mannosidase, alpha, class 1A, member 2
 1238
 0.61
chr13_109924709_109925156 0.25 MYO16-AS1
 MYO16 antisense RNA 1
 71101
 0.13
chr10_82215597_82215808 0.25 TSPAN14
 tetraspanin 14
 1591
 0.41
chr11_33756310_33756563 0.25 CD59
 CD59 molecule, complement regulatory protein
 1518
 0.33
chr4_779234_779385 0.24 RP11-440L14.1
3672
 0.15
chr18_8755384_8755651 0.24 SOGA2
 SOGA family member 2
 34155
 0.14
chr12_9216598_9216767 0.24 A2M-AS1
 A2M antisense RNA 1
 1091
 0.49
chr20_2802410_2802561 0.24 TMEM239
 transmembrane protein 239
 5506
 0.13
chr5_154229616_154229872 0.24 FAXDC2
 fatty acid hydroxylase domain containing 2
 419
 0.81
chr2_650542_650693 0.24 TMEM18
 transmembrane protein 18
 25158
 0.18
chr6_130453758_130453909 0.23 RP11-73O6.3
5508
 0.26
chr11_64013126_64013464 0.23 PPP1R14B
 protein phosphatase 1, regulatory (inhibitor) subunit 14B
 7
 0.62
chr5_158407500_158407684 0.23 CTD-2363C16.1
2422
 0.33
chr19_37328825_37329012 0.23 ZNF790
 zinc finger protein 790
 11
 0.97
chr2_97472579_97472810 0.23 ENSG00000264157
 .
 8679
 0.13
chr1_116293768_116293919 0.23 CASQ2
 calsequestrin 2 (cardiac muscle)
 17492
 0.24
chr11_118489320_118489642 0.23 PHLDB1
 pleckstrin homology-like domain, family B, member 1
 11123
 0.11
chr13_99967074_99967225 0.23 GPR183
 G protein-coupled receptor 183
 7490
 0.21
chr16_85590478_85590669 0.23 GSE1
 Gse1 coiled-coil protein
 54442
 0.13
chr20_43974638_43974789 0.22 SDC4
 syndecan 4
 2351
 0.19
chr2_33165553_33165704 0.22 ENSG00000206951
 .
 4890
 0.24
chr11_84028149_84028546 0.22 DLG2
 discs, large homolog 2 (Drosophila)
 35
 0.99
chr12_62654244_62654932 0.22 USP15
 ubiquitin specific peptidase 15
 379
 0.66
chr16_51180371_51180536 0.22 AC009166.5
2697
 0.32
chr5_1331289_1331440 0.22 CLPTM1L
 CLPTM1-like
 10489
 0.17
chr16_2880049_2880363 0.22 ZG16B
 zymogen granule protein 16B
 36
 0.94
chr9_130825291_130825442 0.22 NAIF1
 nuclear apoptosis inducing factor 1
 4234
 0.11
chr1_16122451_16122602 0.22 FBLIM1
 filamin binding LIM protein 1
 31078
 0.1
chr18_67425087_67425238 0.22 RP11-543H23.2
32951
 0.22
chr6_28949532_28949984 0.21 HCG15
 HLA complex group 15 (non-protein coding)
 4222
 0.13
chr2_163099011_163099583 0.21 FAP
 fibroblast activation protein, alpha
 261
 0.94
chr3_73597243_73597428 0.21 PDZRN3
 PDZ domain containing ring finger 3
 13434
 0.24
chr17_58157127_58157278 0.21 HEATR6
 HEAT repeat containing 6
 910
 0.49
chr11_46724199_46724350 0.21 ZNF408
 zinc finger protein 408
 1906
 0.21
chr7_150811251_150811777 0.21 AGAP3
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
 251
 0.86
chr1_55370578_55370729 0.21 RP11-67L3.4
17248
 0.14
chr22_42476102_42476312 0.21 SMDT1
 single-pass membrane protein with aspartate-rich tail 1
 508
 0.6
chr3_42728895_42729046 0.21 KLHL40
 kelch-like family member 40
 1959
 0.19
chr4_88140632_88141014 0.21 KLHL8
 kelch-like family member 8
 597
 0.81
chr17_26988932_26989176 0.21 SUPT6H
 suppressor of Ty 6 homolog (S. cerevisiae)
 55
 0.59
chr9_12575381_12575532 0.21 TYRP1
 tyrosinase-related protein 1
 109983
 0.07
chr9_118174215_118174366 0.21 DEC1
 deleted in esophageal cancer 1
 270193
 0.02
chr6_18397050_18397268 0.20 ENSG00000238458
 .
 5124
 0.24
chr12_81474615_81474766 0.20 ACSS3
 acyl-CoA synthetase short-chain family member 3
 2854
 0.32
chr18_30349192_30349343 0.20 AC012123.1
 Uncharacterized protein
 491
 0.81
chr5_7869806_7870194 0.20 MTRR
 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
 374
 0.74
chr3_194928852_194929003 0.20 ENSG00000206600
 .
 6589
 0.18
chr8_28560557_28560810 0.20 EXTL3-AS1
 EXTL3 antisense RNA 1
 1702
 0.31
chr11_18344438_18344755 0.20 GTF2H1
 general transcription factor IIH, polypeptide 1, 62kDa
 453
 0.61
chr6_39761310_39761623 0.20 DAAM2
 dishevelled associated activator of morphogenesis 2
 672
 0.79
chr8_29498654_29498805 0.20 ENSG00000221003
 .
 287392
 0.01
chr3_71112065_71112645 0.19 FOXP1
 forkhead box P1
 1722
 0.53
chr4_89741704_89741855 0.19 FAM13A
 family with sequence similarity 13, member A
 2573
 0.37
chr16_47178196_47178489 0.19 RP11-329J18.2
13
 0.88
chr7_132260236_132260613 0.19 PLXNA4
 plexin A4
 805
 0.75
chr11_74659771_74660083 0.19 XRRA1
 X-ray radiation resistance associated 1
 138
 0.75
chr3_151997671_151997822 0.19 MBNL1-AS1
 MBNL1 antisense RNA 1
 10402
 0.22
chr16_85768972_85769153 0.19 ENSG00000222190
 .
 6244
 0.13
chr17_12568958_12569229 0.19 MYOCD
 myocardin
 213
 0.95
chr4_111084991_111085142 0.19 ELOVL6
 ELOVL fatty acid elongase 6
 34743
 0.18
chr3_50297269_50297420 0.19 SEMA3B-AS1
 SEMA3B antisense RNA 1 (head to head)
 7459
 0.09
chr6_7312252_7312483 0.19 SSR1
 signal sequence receptor, alpha
 1040
 0.57
chrX_71288852_71289006 0.19 RGAG4
 retrotransposon gag domain containing 4
 62749
 0.1
chr12_51319016_51319581 0.19 METTL7A
 methyltransferase like 7A
 764
 0.59
chr17_76182522_76182694 0.19 TK1
 thymidine kinase 1, soluble
 503
 0.53
chr21_35305075_35305226 0.18 LINC00649
 long intergenic non-protein coding RNA 649
 1632
 0.32
chr2_160469080_160469419 0.18 AC009506.1
2558
 0.28
chr15_22514117_22514287 0.18 ENSG00000221641
 .
 922
 0.52
chr1_179199050_179199491 0.18 ABL2
 c-abl oncogene 2, non-receptor tyrosine kinase
 451
 0.82
chr15_61266463_61266614 0.18 RP11-39M21.1
206910
 0.02
chr9_136556754_136556905 0.18 SARDH
 sarcosine dehydrogenase
 11994
 0.18
chr5_14178346_14178639 0.18 TRIO
 trio Rho guanine nucleotide exchange factor
 5415
 0.35
chr1_231177146_231177297 0.18 FAM89A
 family with sequence similarity 89, member A
 1229
 0.43
chr1_180199493_180199788 0.18 LHX4
 LIM homeobox 4
 219
 0.95
chr20_42143535_42143824 0.18 L3MBTL1
 l(3)mbt-like 1 (Drosophila)
 513
 0.75
chr6_143037024_143037175 0.18 RP1-67K17.3
32481
 0.23
chr17_44668558_44668782 0.18 NSF
 N-ethylmaleimide-sensitive factor
 283
 0.9
chr11_72145394_72145582 0.18 CLPB
 ClpB caseinolytic peptidase B homolog (E. coli)
 62
 0.97
chr9_128288500_128288651 0.18 ENSG00000243845
 .
 13089
 0.21
chr11_65267780_65268262 0.18 SCYL1
 SCY1-like 1 (S. cerevisiae)
 24527
 0.09
chr17_73852253_73852511 0.18 WBP2
 WW domain binding protein 2
 206
 0.86
chr17_33868045_33868636 0.18 SLFN12L
 schlafen family member 12-like
 3460
 0.14
chr13_109809143_109809440 0.18 MYO16-AS1
 MYO16 antisense RNA 1
 44540
 0.18
chr6_2901280_2901469 0.18 SERPINB9
 serpin peptidase inhibitor, clade B (ovalbumin), member 9
 2140
 0.3
chr6_139868311_139868622 0.18 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 172709
 0.03
chr15_34620156_34620427 0.18 SLC12A6
 solute carrier family 12 (potassium/chloride transporter), member 6
 8754
 0.11
chr1_43826510_43826891 0.17 CDC20
 cell division cycle 20
 2016
 0.17
chr10_28822829_28823308 0.17 WAC
 WW domain containing adaptor with coiled-coil
 16
 0.97
chr1_79306379_79306727 0.17 ELTD1
 EGF, latrophilin and seven transmembrane domain containing 1
 77017
 0.11
chr19_49139505_49139656 0.17 DBP
 D site of albumin promoter (albumin D-box) binding protein
 1040
 0.28
chr16_29825122_29825273 0.17 PRRT2
 proline-rich transmembrane protein 2
 1633
 0.13
chr10_82232604_82232771 0.17 TSPAN14
 tetraspanin 14
 13629
 0.2
chr22_36753608_36753885 0.17 MYH9
 myosin, heavy chain 9, non-muscle
 7410
 0.2
chr13_34492968_34493208 0.17 ENSG00000263663
 .
 6959
 0.3
chr16_57835623_57835864 0.17 KIFC3
 kinesin family member C3
 618
 0.65
chr18_5237293_5237735 0.17 C18orf42
 chromosome 18 open reading frame 42
 40012
 0.18
chr16_70380861_70381493 0.17 DDX19A
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
 330
 0.6
chr11_2924254_2924405 0.17 SLC22A18
 solute carrier family 22, member 18
 15
 0.86
chr9_134297852_134298003 0.17 PRRC2B
 proline-rich coiled-coil 2B
 7550
 0.21
chr1_45267568_45268118 0.17 PLK3
 polo-like kinase 3
 1946
 0.13
chr18_73496416_73496569 0.17 SMIM21
 small integral membrane protein 21
 356834
 0.01
chr12_85304928_85305252 0.17 SLC6A15
 solute carrier family 6 (neutral amino acid transporter), member 15
 713
 0.8
chr2_122287274_122287589 0.17 RP11-204L24.2
567
 0.62
chr11_84148388_84148632 0.17 DLG2
 discs, large homolog 2 (Drosophila)
 120128
 0.07
chr2_67095961_67096112 0.17 MEIS1
 Meis homeobox 1
 359977
 0.01
chr1_151170363_151170514 0.17 PIP5K1A
 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
 13
 0.95
chr1_193073507_193073986 0.16 GLRX2
 glutaredoxin 2
 815
 0.53
chr17_44344782_44345197 0.16 RP11-259G18.1
211
 0.93
chr5_139726315_139726693 0.16 HBEGF
 heparin-binding EGF-like growth factor
 288
 0.85
chr1_161276676_161276935 0.16 MPZ
 myelin protein zero
 456
 0.72
chr7_99868283_99868434 0.16 GATS
1216
 0.3
chr6_164530063_164530741 0.16 ENSG00000266128
 .
 268809
 0.02
chr9_33446798_33447442 0.16 AQP3
 aquaporin 3 (Gill blood group)
 489
 0.76
chr6_24775111_24775564 0.16 GMNN
 geminin, DNA replication inhibitor
 171
 0.94
chr5_83220316_83220467 0.16 ENSG00000216125
 .
 49314
 0.18
chr1_40847174_40847476 0.16 SMAP2
 small ArfGAP2
 7005
 0.19
chr3_186743256_186743535 0.16 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 124
 0.97
chr7_75267461_75267701 0.16 HIP1
 huntingtin interacting protein 1
 26420
 0.17
chr4_30725920_30726277 0.16 PCDH7
 protocadherin 7
 2121
 0.46
chr15_75085209_75085360 0.16 CSK
 c-src tyrosine kinase
 101
 0.94
chr17_74323765_74323916 0.16 ENSG00000238418
 .
 3563
 0.13
chr10_111488296_111488447 0.16 ENSG00000272160
 .
 141245
 0.05
chr15_22482994_22483145 0.16 IGHV1OR15-4
 immunoglobulin heavy variable 1/OR15-4 (pseudogene)
 199
 0.91
chr11_104941226_104941560 0.16 CARD16
 caspase recruitment domain family, member 16
 25290
 0.15
chr12_121199647_121199798 0.16 RP11-173P15.7
327
 0.84
chr3_111849268_111849419 0.16 GCSAM
 germinal center-associated, signaling and motility
 2729
 0.22
chr6_127837776_127838009 0.16 SOGA3
 SOGA family member 3
 133
 0.97
chr1_27021420_27021612 0.16 RP5-968P14.2
894
 0.39
chr2_121199524_121199751 0.16 LINC01101
 long intergenic non-protein coding RNA 1101
 24060
 0.24
chr4_111007994_111008259 0.16 ENSG00000263940
 .
 30766
 0.21
chr13_101194913_101195273 0.16 RP11-151A6.4
3033
 0.25
chr3_71354045_71354526 0.16 FOXP1
 forkhead box P1
 374
 0.9
chr18_53296660_53296811 0.16 TCF4
 transcription factor 4
 1858
 0.49
chr15_52044209_52044706 0.16 CTD-2308G16.1
225
 0.69
chr1_202428982_202429290 0.16 PPP1R12B
 protein phosphatase 1, regulatory subunit 12B
 2735
 0.3
chr2_198243514_198243752 0.16 SF3B1
 splicing factor 3b, subunit 1, 155kDa
 20119
 0.14
chr8_59718017_59718168 0.16 ENSG00000201231
 .
 9019
 0.29
chr3_85442393_85442544 0.16 ENSG00000264084
 .
 7608
 0.34
chr7_42276328_42276548 0.16 GLI3
 GLI family zinc finger 3
 174
 0.98
chr6_45601331_45601597 0.16 ENSG00000252738
 .
 12377
 0.3
chr19_8387111_8387400 0.16 RPS28
 ribosomal protein S28
 871
 0.33
chr4_54243416_54243714 0.16 FIP1L1
 factor interacting with PAPOLA and CPSF1
 247
 0.94
chr7_130920122_130920273 0.16 MKLN1
 muskelin 1, intracellular mediator containing kelch motifs
 49624
 0.16
chr7_92860979_92861490 0.16 CCDC132
 coiled-coil domain containing 132
 419
 0.86
chr18_29522149_29522354 0.15 RP11-326K13.4
287
 0.76
chr4_68410033_68410229 0.15 CENPC
 centromere protein C
 1193
 0.53
chr1_244893030_244893263 0.15 DESI2
 desumoylating isopeptidase 2
 76093
 0.09
chr4_127701440_127701591 0.15 ENSG00000199862
 .
 247859
 0.02
chr5_50040216_50040933 0.15 PARP8
 poly (ADP-ribose) polymerase family, member 8
 77183
 0.12
chr17_8424688_8424839 0.15 ENSG00000252363
 .
 10320
 0.17
chr1_181002765_181003143 0.15 MR1
 major histocompatibility complex, class I-related
 113
 0.96
chr2_177029952_177030103 0.15 RP11-387A1.5
417
 0.62
chr8_23145924_23146455 0.15 R3HCC1
 R3H domain and coiled-coil containing 1
 254
 0.9
chr11_1909549_1909755 0.15 C11orf89
 chromosome 11 open reading frame 89
 2432
 0.16
chr15_38852027_38852178 0.15 RASGRP1
 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
 181
 0.95
chr7_6576295_6576446 0.15 GRID2IP
 glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein
 158
 0.94
chr9_45727635_45727849 0.15 FAM27A
 family with sequence similarity 27, member A
 635
 0.72
chr17_48797268_48797811 0.15 LUC7L3
 LUC7-like 3 (S. cerevisiae)
 531
 0.69

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.2 GO:0010716 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1 0.3 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.2 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.1 0.4 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 0.2 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 0.2 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.1 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0046618 drug export(GO:0046618)
0.0 0.2 GO:0045217 cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0 0.2 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.0 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.0 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.1 GO:0035588 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.1 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0023058 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.2 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.2 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 0.1 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.1 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.1 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.1 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.1 GO:0006863 purine nucleobase transport(GO:0006863)
0.0 0.0 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.0 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.0 GO:2000192 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.0 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.0 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0010915 regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0 0.0 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.0 0.0 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.3 GO:0034080 DNA replication-independent nucleosome assembly(GO:0006336) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:1901532 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101)
0.0 0.0 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.0 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.0 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.0 GO:0090116 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.0 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.0 GO:0006530 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.1 GO:0045909 positive regulation of vasodilation(GO:0045909)
0.0 0.1 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0 0.1 GO:0001660 fever generation(GO:0001660)
0.0 0.0 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.1 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0 0.1 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.2 GO:0070206 protein trimerization(GO:0070206)
0.0 0.0 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.2 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.0 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)
0.0 0.1 GO:0045240 dihydrolipoyl dehydrogenase complex(GO:0045240)
0.0 0.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.5 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.2 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0071565 nBAF complex(GO:0071565)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.0 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.0 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.2 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.2 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0015520 tetracycline:proton antiporter activity(GO:0015520)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0046030 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0 0.1 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.1 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0 0.0 GO:0043495 protein anchor(GO:0043495)
0.0 0.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.0 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.0 GO:0005113 patched binding(GO:0005113)
0.0 0.0 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.2 GO:0060590 ATPase regulator activity(GO:0060590)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0061630 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0033558 protein deacetylase activity(GO:0033558)
0.0 0.0 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.0 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.1 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0003711 obsolete transcription elongation regulator activity(GO:0003711)
0.0 0.0 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.0 GO:0000739 obsolete DNA strand annealing activity(GO:0000739)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.4 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.1 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.0 0.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.0 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.0 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12