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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PKNOX2

Z-value: 1.06

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Transcription factors associated with PKNOX2

Gene Symbol	Gene ID	Gene Info
PKNOX2 Ensembl NCBI GeneCards UniProt	ENSG00000165495.11	PKNOX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PKNOX2	chr11_125035186_125035397	641	0.474796	0.59	9.3e-02	Click!
PKNOX2	chr11_125039995_125040154	5424	0.166772	0.57	1.1e-01	Click!
PKNOX2	chr11_125036574_125036725	1999	0.244857	0.54	1.3e-01	Click!
PKNOX2	chr11_125036127_125036278	1552	0.286129	0.51	1.6e-01	Click!
PKNOX2	chr11_125035763_125035964	1213	0.334760	0.48	1.9e-01	Click!

Activity of the PKNOX2 motif across conditions

Conditions sorted by the z-value of the PKNOX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_65530319_65530470	0.48	ENSG00000199135	.	6203	0.2
chr1_66258257_66258503	0.44	PDE4B	phosphodiesterase 4B, cAMP-specific	183	0.96
chrX_100334236_100334411	0.43	TMEM35	transmembrane protein 35	614	0.68
chr9_19128575_19128726	0.40	PLIN2	perilipin 2	1076	0.44
chr6_5498765_5499077	0.39	RP1-232P20.1		40613	0.2
chr5_67577155_67577306	0.38	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	1095	0.66
chr5_56112470_56113088	0.38	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	1378	0.44
chr16_68693087_68693238	0.37	RP11-615I2.2		13091	0.13
chr1_21859764_21859915	0.36	ALPL	alkaline phosphatase, liver/bone/kidney	17933	0.19
chr19_49121963_49122114	0.36	RPL18	ribosomal protein L18	346	0.53
chr6_82732214_82732365	0.35	ENSG00000223044	.	187868	0.03
chr1_95389567_95389941	0.34	CNN3	calponin 3, acidic	1583	0.36
chr11_3043840_3044115	0.34	CARS-AS1	CARS antisense RNA 1	6647	0.13
chr14_30054222_30054373	0.33	PRKD1	protein kinase D1	49383	0.15
chr12_90272914_90273065	0.33	ENSG00000252823	.	125153	0.06
chr16_89381066_89381217	0.33	AC137932.6		6400	0.14
chr5_157714663_157714814	0.32	ENSG00000222626	.	310774	0.01
chr2_47401669_47401853	0.31	CALM2	calmodulin 2 (phosphorylase kinase, delta)	1889	0.37
chr20_47894397_47894608	0.31	ZNFX1	zinc finger, NFX1-type containing 1	76	0.67
chr6_24910150_24910301	0.30	FAM65B	family with sequence similarity 65, member B	970	0.62
chr1_109740352_109740715	0.30	ENSG00000238310	.	9937	0.15
chr12_92440588_92440837	0.30	C12orf79	chromosome 12 open reading frame 79	90085	0.08
chr14_92331424_92331867	0.30	TC2N	tandem C2 domains, nuclear	2228	0.32
chr22_23282661_23282812	0.30	IGLJ7	immunoglobulin lambda joining 7	19174	0.07
chr20_8380586_8380742	0.30	PLCB1-IT1	PLCB1 intronic transcript 1 (non-protein coding)	151292	0.04
chr5_163147994_163148145	0.29	ENSG00000251998	.	75102	0.12
chrX_100352542_100352928	0.29	CENPI	centromere protein I	443	0.78
chr6_131255225_131255376	0.29	EPB41L2	erythrocyte membrane protein band 4.1-like 2	22325	0.27
chr4_3529804_3529955	0.29	LRPAP1	low density lipoprotein receptor-related protein associated protein 1	4407	0.19
chr7_99516388_99516774	0.28	TRIM4	tripartite motif containing 4	147	0.91
chr4_141217305_141217524	0.28	ENSG00000252300	.	21148	0.19
chr13_53419960_53420114	0.28	PCDH8	protocadherin 8	2603	0.34
chr4_139813437_139813623	0.28	RP11-371F15.3		45605	0.16
chr3_50298349_50298500	0.28	SEMA3B-AS1	SEMA3B antisense RNA 1 (head to head)	6379	0.09
chr1_33804639_33805031	0.28	ENSG00000222112	.	2370	0.19
chr6_82854353_82854866	0.27	ENSG00000223044	.	65548	0.14
chr6_162052389_162052540	0.27	ENSG00000221021	.	16366	0.31
chr19_46171409_46171560	0.27	GIPR	gastric inhibitory polypeptide receptor	18	0.94
chr11_111741428_111741733	0.26	ALG9	ALG9, alpha-1,2-mannosyltransferase	8	0.96
chr5_32175143_32175294	0.26	GOLPH3	golgi phosphoprotein 3 (coat-protein)	762	0.67
chr4_178324604_178324755	0.25	AGA	aspartylglucosaminidase	36099	0.14
chr8_37728655_37728889	0.25	RAB11FIP1	RAB11 family interacting protein 1 (class I)	6863	0.15
chr1_117910944_117911674	0.25	MAN1A2	mannosidase, alpha, class 1A, member 2	1238	0.61
chr13_109924709_109925156	0.25	MYO16-AS1	MYO16 antisense RNA 1	71101	0.13
chr10_82215597_82215808	0.25	TSPAN14	tetraspanin 14	1591	0.41
chr11_33756310_33756563	0.25	CD59	CD59 molecule, complement regulatory protein	1518	0.33
chr4_779234_779385	0.24	RP11-440L14.1		3672	0.15
chr18_8755384_8755651	0.24	SOGA2	SOGA family member 2	34155	0.14
chr12_9216598_9216767	0.24	A2M-AS1	A2M antisense RNA 1	1091	0.49
chr20_2802410_2802561	0.24	TMEM239	transmembrane protein 239	5506	0.13
chr5_154229616_154229872	0.24	FAXDC2	fatty acid hydroxylase domain containing 2	419	0.81
chr2_650542_650693	0.24	TMEM18	transmembrane protein 18	25158	0.18
chr6_130453758_130453909	0.23	RP11-73O6.3		5508	0.26
chr11_64013126_64013464	0.23	PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B	7	0.62
chr5_158407500_158407684	0.23	CTD-2363C16.1		2422	0.33
chr19_37328825_37329012	0.23	ZNF790	zinc finger protein 790	11	0.97
chr2_97472579_97472810	0.23	ENSG00000264157	.	8679	0.13
chr1_116293768_116293919	0.23	CASQ2	calsequestrin 2 (cardiac muscle)	17492	0.24
chr11_118489320_118489642	0.23	PHLDB1	pleckstrin homology-like domain, family B, member 1	11123	0.11
chr13_99967074_99967225	0.23	GPR183	G protein-coupled receptor 183	7490	0.21
chr16_85590478_85590669	0.23	GSE1	Gse1 coiled-coil protein	54442	0.13
chr20_43974638_43974789	0.22	SDC4	syndecan 4	2351	0.19
chr2_33165553_33165704	0.22	ENSG00000206951	.	4890	0.24
chr11_84028149_84028546	0.22	DLG2	discs, large homolog 2 (Drosophila)	35	0.99
chr12_62654244_62654932	0.22	USP15	ubiquitin specific peptidase 15	379	0.66
chr16_51180371_51180536	0.22	AC009166.5		2697	0.32
chr5_1331289_1331440	0.22	CLPTM1L	CLPTM1-like	10489	0.17
chr16_2880049_2880363	0.22	ZG16B	zymogen granule protein 16B	36	0.94
chr9_130825291_130825442	0.22	NAIF1	nuclear apoptosis inducing factor 1	4234	0.11
chr1_16122451_16122602	0.22	FBLIM1	filamin binding LIM protein 1	31078	0.1
chr18_67425087_67425238	0.22	RP11-543H23.2		32951	0.22
chr6_28949532_28949984	0.21	HCG15	HLA complex group 15 (non-protein coding)	4222	0.13
chr2_163099011_163099583	0.21	FAP	fibroblast activation protein, alpha	261	0.94
chr3_73597243_73597428	0.21	PDZRN3	PDZ domain containing ring finger 3	13434	0.24
chr17_58157127_58157278	0.21	HEATR6	HEAT repeat containing 6	910	0.49
chr11_46724199_46724350	0.21	ZNF408	zinc finger protein 408	1906	0.21
chr7_150811251_150811777	0.21	AGAP3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	251	0.86
chr1_55370578_55370729	0.21	RP11-67L3.4		17248	0.14
chr22_42476102_42476312	0.21	SMDT1	single-pass membrane protein with aspartate-rich tail 1	508	0.6
chr3_42728895_42729046	0.21	KLHL40	kelch-like family member 40	1959	0.19
chr4_88140632_88141014	0.21	KLHL8	kelch-like family member 8	597	0.81
chr17_26988932_26989176	0.21	SUPT6H	suppressor of Ty 6 homolog (S. cerevisiae)	55	0.59
chr9_12575381_12575532	0.21	TYRP1	tyrosinase-related protein 1	109983	0.07
chr9_118174215_118174366	0.21	DEC1	deleted in esophageal cancer 1	270193	0.02
chr6_18397050_18397268	0.20	ENSG00000238458	.	5124	0.24
chr12_81474615_81474766	0.20	ACSS3	acyl-CoA synthetase short-chain family member 3	2854	0.32
chr18_30349192_30349343	0.20	AC012123.1	Uncharacterized protein	491	0.81
chr5_7869806_7870194	0.20	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	374	0.74
chr3_194928852_194929003	0.20	ENSG00000206600	.	6589	0.18
chr8_28560557_28560810	0.20	EXTL3-AS1	EXTL3 antisense RNA 1	1702	0.31
chr11_18344438_18344755	0.20	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa	453	0.61
chr6_39761310_39761623	0.20	DAAM2	dishevelled associated activator of morphogenesis 2	672	0.79
chr8_29498654_29498805	0.20	ENSG00000221003	.	287392	0.01
chr3_71112065_71112645	0.19	FOXP1	forkhead box P1	1722	0.53
chr4_89741704_89741855	0.19	FAM13A	family with sequence similarity 13, member A	2573	0.37
chr16_47178196_47178489	0.19	RP11-329J18.2		13	0.88
chr7_132260236_132260613	0.19	PLXNA4	plexin A4	805	0.75
chr11_74659771_74660083	0.19	XRRA1	X-ray radiation resistance associated 1	138	0.75
chr3_151997671_151997822	0.19	MBNL1-AS1	MBNL1 antisense RNA 1	10402	0.22
chr16_85768972_85769153	0.19	ENSG00000222190	.	6244	0.13
chr17_12568958_12569229	0.19	MYOCD	myocardin	213	0.95
chr4_111084991_111085142	0.19	ELOVL6	ELOVL fatty acid elongase 6	34743	0.18
chr3_50297269_50297420	0.19	SEMA3B-AS1	SEMA3B antisense RNA 1 (head to head)	7459	0.09
chr6_7312252_7312483	0.19	SSR1	signal sequence receptor, alpha	1040	0.57
chrX_71288852_71289006	0.19	RGAG4	retrotransposon gag domain containing 4	62749	0.1
chr12_51319016_51319581	0.19	METTL7A	methyltransferase like 7A	764	0.59
chr17_76182522_76182694	0.19	TK1	thymidine kinase 1, soluble	503	0.53
chr21_35305075_35305226	0.18	LINC00649	long intergenic non-protein coding RNA 649	1632	0.32
chr2_160469080_160469419	0.18	AC009506.1		2558	0.28
chr15_22514117_22514287	0.18	ENSG00000221641	.	922	0.52
chr1_179199050_179199491	0.18	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	451	0.82
chr15_61266463_61266614	0.18	RP11-39M21.1		206910	0.02
chr9_136556754_136556905	0.18	SARDH	sarcosine dehydrogenase	11994	0.18
chr5_14178346_14178639	0.18	TRIO	trio Rho guanine nucleotide exchange factor	5415	0.35
chr1_231177146_231177297	0.18	FAM89A	family with sequence similarity 89, member A	1229	0.43
chr1_180199493_180199788	0.18	LHX4	LIM homeobox 4	219	0.95
chr20_42143535_42143824	0.18	L3MBTL1	l(3)mbt-like 1 (Drosophila)	513	0.75
chr6_143037024_143037175	0.18	RP1-67K17.3		32481	0.23
chr17_44668558_44668782	0.18	NSF	N-ethylmaleimide-sensitive factor	283	0.9
chr11_72145394_72145582	0.18	CLPB	ClpB caseinolytic peptidase B homolog (E. coli)	62	0.97
chr9_128288500_128288651	0.18	ENSG00000243845	.	13089	0.21
chr11_65267780_65268262	0.18	SCYL1	SCY1-like 1 (S. cerevisiae)	24527	0.09
chr17_73852253_73852511	0.18	WBP2	WW domain binding protein 2	206	0.86
chr17_33868045_33868636	0.18	SLFN12L	schlafen family member 12-like	3460	0.14
chr13_109809143_109809440	0.18	MYO16-AS1	MYO16 antisense RNA 1	44540	0.18
chr6_2901280_2901469	0.18	SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	2140	0.3
chr6_139868311_139868622	0.18	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	172709	0.03
chr15_34620156_34620427	0.18	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	8754	0.11
chr1_43826510_43826891	0.17	CDC20	cell division cycle 20	2016	0.17
chr10_28822829_28823308	0.17	WAC	WW domain containing adaptor with coiled-coil	16	0.97
chr1_79306379_79306727	0.17	ELTD1	EGF, latrophilin and seven transmembrane domain containing 1	77017	0.11
chr19_49139505_49139656	0.17	DBP	D site of albumin promoter (albumin D-box) binding protein	1040	0.28
chr16_29825122_29825273	0.17	PRRT2	proline-rich transmembrane protein 2	1633	0.13
chr10_82232604_82232771	0.17	TSPAN14	tetraspanin 14	13629	0.2
chr22_36753608_36753885	0.17	MYH9	myosin, heavy chain 9, non-muscle	7410	0.2
chr13_34492968_34493208	0.17	ENSG00000263663	.	6959	0.3
chr16_57835623_57835864	0.17	KIFC3	kinesin family member C3	618	0.65
chr18_5237293_5237735	0.17	C18orf42	chromosome 18 open reading frame 42	40012	0.18
chr16_70380861_70381493	0.17	DDX19A	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A	330	0.6
chr11_2924254_2924405	0.17	SLC22A18	solute carrier family 22, member 18	15	0.86
chr9_134297852_134298003	0.17	PRRC2B	proline-rich coiled-coil 2B	7550	0.21
chr1_45267568_45268118	0.17	PLK3	polo-like kinase 3	1946	0.13
chr18_73496416_73496569	0.17	SMIM21	small integral membrane protein 21	356834	0.01
chr12_85304928_85305252	0.17	SLC6A15	solute carrier family 6 (neutral amino acid transporter), member 15	713	0.8
chr2_122287274_122287589	0.17	RP11-204L24.2		567	0.62
chr11_84148388_84148632	0.17	DLG2	discs, large homolog 2 (Drosophila)	120128	0.07
chr2_67095961_67096112	0.17	MEIS1	Meis homeobox 1	359977	0.01
chr1_151170363_151170514	0.17	PIP5K1A	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	13	0.95
chr1_193073507_193073986	0.16	GLRX2	glutaredoxin 2	815	0.53
chr17_44344782_44345197	0.16	RP11-259G18.1		211	0.93
chr5_139726315_139726693	0.16	HBEGF	heparin-binding EGF-like growth factor	288	0.85
chr1_161276676_161276935	0.16	MPZ	myelin protein zero	456	0.72
chr7_99868283_99868434	0.16	GATS		1216	0.3
chr6_164530063_164530741	0.16	ENSG00000266128	.	268809	0.02
chr9_33446798_33447442	0.16	AQP3	aquaporin 3 (Gill blood group)	489	0.76
chr6_24775111_24775564	0.16	GMNN	geminin, DNA replication inhibitor	171	0.94
chr5_83220316_83220467	0.16	ENSG00000216125	.	49314	0.18
chr1_40847174_40847476	0.16	SMAP2	small ArfGAP2	7005	0.19
chr3_186743256_186743535	0.16	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	124	0.97
chr7_75267461_75267701	0.16	HIP1	huntingtin interacting protein 1	26420	0.17
chr4_30725920_30726277	0.16	PCDH7	protocadherin 7	2121	0.46
chr15_75085209_75085360	0.16	CSK	c-src tyrosine kinase	101	0.94
chr17_74323765_74323916	0.16	ENSG00000238418	.	3563	0.13
chr10_111488296_111488447	0.16	ENSG00000272160	.	141245	0.05
chr15_22482994_22483145	0.16	IGHV1OR15-4	immunoglobulin heavy variable 1/OR15-4 (pseudogene)	199	0.91
chr11_104941226_104941560	0.16	CARD16	caspase recruitment domain family, member 16	25290	0.15
chr12_121199647_121199798	0.16	RP11-173P15.7		327	0.84
chr3_111849268_111849419	0.16	GCSAM	germinal center-associated, signaling and motility	2729	0.22
chr6_127837776_127838009	0.16	SOGA3	SOGA family member 3	133	0.97
chr1_27021420_27021612	0.16	RP5-968P14.2		894	0.39
chr2_121199524_121199751	0.16	LINC01101	long intergenic non-protein coding RNA 1101	24060	0.24
chr4_111007994_111008259	0.16	ENSG00000263940	.	30766	0.21
chr13_101194913_101195273	0.16	RP11-151A6.4		3033	0.25
chr3_71354045_71354526	0.16	FOXP1	forkhead box P1	374	0.9
chr18_53296660_53296811	0.16	TCF4	transcription factor 4	1858	0.49
chr15_52044209_52044706	0.16	CTD-2308G16.1		225	0.69
chr1_202428982_202429290	0.16	PPP1R12B	protein phosphatase 1, regulatory subunit 12B	2735	0.3
chr2_198243514_198243752	0.16	SF3B1	splicing factor 3b, subunit 1, 155kDa	20119	0.14
chr8_59718017_59718168	0.16	ENSG00000201231	.	9019	0.29
chr3_85442393_85442544	0.16	ENSG00000264084	.	7608	0.34
chr7_42276328_42276548	0.16	GLI3	GLI family zinc finger 3	174	0.98
chr6_45601331_45601597	0.16	ENSG00000252738	.	12377	0.3
chr19_8387111_8387400	0.16	RPS28	ribosomal protein S28	871	0.33
chr4_54243416_54243714	0.16	FIP1L1	factor interacting with PAPOLA and CPSF1	247	0.94
chr7_130920122_130920273	0.16	MKLN1	muskelin 1, intracellular mediator containing kelch motifs	49624	0.16
chr7_92860979_92861490	0.16	CCDC132	coiled-coil domain containing 132	419	0.86
chr18_29522149_29522354	0.15	RP11-326K13.4		287	0.76
chr4_68410033_68410229	0.15	CENPC	centromere protein C	1193	0.53
chr1_244893030_244893263	0.15	DESI2	desumoylating isopeptidase 2	76093	0.09
chr4_127701440_127701591	0.15	ENSG00000199862	.	247859	0.02
chr5_50040216_50040933	0.15	PARP8	poly (ADP-ribose) polymerase family, member 8	77183	0.12
chr17_8424688_8424839	0.15	ENSG00000252363	.	10320	0.17
chr1_181002765_181003143	0.15	MR1	major histocompatibility complex, class I-related	113	0.96
chr2_177029952_177030103	0.15	RP11-387A1.5		417	0.62
chr8_23145924_23146455	0.15	R3HCC1	R3H domain and coiled-coil containing 1	254	0.9
chr11_1909549_1909755	0.15	C11orf89	chromosome 11 open reading frame 89	2432	0.16
chr15_38852027_38852178	0.15	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	181	0.95
chr7_6576295_6576446	0.15	GRID2IP	glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein	158	0.94
chr9_45727635_45727849	0.15	FAM27A	family with sequence similarity 27, member A	635	0.72
chr17_48797268_48797811	0.15	LUC7L3	LUC7-like 3 (S. cerevisiae)	531	0.69

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.2	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1	0.3	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.1	0.4	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.2	GO:0000212	meiotic spindle organization(GO:0000212)
0.1	0.2	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	0.1	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.1	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.1	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.2	GO:0046618	drug export(GO:0046618)
0.0	0.2	GO:0045217	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.2	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.0	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.3	GO:0009086	methionine biosynthetic process(GO:0009086)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.1	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.1	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.2	GO:0023058	desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.2	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.1	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.2	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.2	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.1	GO:0006863	purine nucleobase transport(GO:0006863)
0.0	0.0	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.0	GO:2000192	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.0	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0010915	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0	0.0	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.3	GO:0034080	DNA replication-independent nucleosome assembly(GO:0006336) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641)
0.0	0.1	GO:1901532	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.0	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.2	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0031498	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.0	GO:0006530	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.1	GO:0045909	positive regulation of vasodilation(GO:0045909)
0.0	0.1	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.1	GO:0001660	fever generation(GO:0001660)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0006734	NADH metabolic process(GO:0006734)
0.0	0.1	GO:0006743	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.2	GO:0070206	protein trimerization(GO:0070206)
0.0	0.0	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.2	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.2	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0045240	dihydrolipoyl dehydrogenase complex(GO:0045240)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.5	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.2	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.2	GO:0071565	nBAF complex(GO:0071565)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.0	0.0	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0	0.1	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.2	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.3	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.2	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.1	0.2	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.2	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.4	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.4	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.2	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.4	GO:0000030	mannosyltransferase activity(GO:0000030)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.2	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.2	GO:0046030	inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0	0.1	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.0	0.1	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.0	GO:0043495	protein anchor(GO:0043495)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.0	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.2	GO:0060590	ATPase regulator activity(GO:0060590)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:0061630	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.2	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0033558	protein deacetylase activity(GO:0033558)
0.0	0.0	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.0	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.0	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.2	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.0	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.0	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.4	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.6	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.1	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.3	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling
0.2	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.3	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.3	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12