Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for POU2F2_POU3F1

Z-value: 0.74

Motif logo

Transcription factors associated with POU2F2_POU3F1

Gene Symbol	Gene ID	Gene Info
POU2F2 Ensembl NCBI GeneCards UniProt	ENSG00000028277.16	POU2F2
POU3F1 Ensembl NCBI GeneCards UniProt	ENSG00000185668.5	POU3F1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
POU2F2	chr19_42617987_42618295	2898	0.138953	-0.72	3.0e-02	Click!
POU2F2	chr19_42592755_42592969	6695	0.106865	-0.66	5.4e-02	Click!
POU2F2	chr19_42618337_42618532	2605	0.148628	-0.52	1.5e-01	Click!
POU2F2	chr19_42626536_42626691	119	0.926435	0.49	1.8e-01	Click!
POU2F2	chr19_42618636_42618787	2328	0.160988	-0.47	2.0e-01	Click!
POU3F1	chr1_38504855_38505006	7520	0.148058	-0.56	1.1e-01	Click!
POU3F1	chr1_38510021_38510235	2322	0.237855	-0.50	1.7e-01	Click!
POU3F1	chr1_38512756_38512948	402	0.815332	-0.43	2.5e-01	Click!
POU3F1	chr1_38512142_38512303	228	0.913864	-0.38	3.2e-01	Click!
POU3F1	chr1_38513049_38513583	866	0.543140	-0.35	3.5e-01	Click!

Activity of the POU2F2_POU3F1 motif across conditions

Conditions sorted by the z-value of the POU2F2_POU3F1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_40551802_40551953	0.40	LRRK2	leucine-rich repeat kinase 2	38669	0.17
chr20_47435196_47435347	0.34	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	9149	0.27
chr7_36763519_36763817	0.34	AOAH	acyloxyacyl hydrolase (neutrophil)	386	0.9
chr2_198756913_198757256	0.33	PLCL1	phospholipase C-like 1	82102	0.1
chr7_50351765_50352753	0.32	IKZF1	IKAROS family zinc finger 1 (Ikaros)	3941	0.34
chr17_8857533_8857684	0.31	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	11416	0.24
chrX_153190817_153191535	0.30	ARHGAP4	Rho GTPase activating protein 4	522	0.6
chrX_78407653_78407829	0.30	GPR174	G protein-coupled receptor 174	18728	0.29
chr19_41808988_41809179	0.30	CCDC97	coiled-coil domain containing 97	7011	0.11
chr11_118305386_118306890	0.30	RP11-770J1.4		217	0.83
chr11_6766362_6766695	0.26	GVINP1	GTPase, very large interferon inducible pseudogene 1	23417	0.11
chr8_27237031_27237182	0.26	PTK2B	protein tyrosine kinase 2 beta	1062	0.59
chr4_113209604_113209755	0.26	TIFA	TRAF-interacting protein with forkhead-associated domain	2620	0.23
chr9_95822109_95822464	0.26	SUSD3	sushi domain containing 3	1225	0.45
chr17_29641266_29641417	0.26	EVI2B	ecotropic viral integration site 2B	211	0.9
chr13_99911056_99911338	0.25	GPR18	G protein-coupled receptor 18	515	0.8
chr4_165040749_165040900	0.25	MARCH1	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	264317	0.02
chr5_56484038_56484189	0.25	GPBP1	GC-rich promoter binding protein 1	12340	0.23
chr3_71632242_71632973	0.25	FOXP1	forkhead box P1	297	0.91
chr5_10632325_10632658	0.24	ANKRD33B-AS1	ANKRD33B antisense RNA 1	4154	0.28
chr2_231586611_231586796	0.24	CAB39	calcium binding protein 39	8440	0.22
chr5_130883505_130884015	0.24	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	15034	0.29
chr21_15916676_15916915	0.23	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	1867	0.42
chr7_33078848_33079779	0.23	NT5C3A	5'-nucleotidase, cytosolic IIIA	1208	0.42
chr1_239883177_239883989	0.23	CHRM3	cholinergic receptor, muscarinic 3	740	0.59
chr11_34649048_34649199	0.23	EHF	ets homologous factor	3300	0.35
chr6_13397968_13398119	0.23	GFOD1	glucose-fructose oxidoreductase domain containing 1	10326	0.22
chr7_137620232_137620510	0.23	CREB3L2	cAMP responsive element binding protein 3-like 2	1735	0.39
chr1_6520196_6520500	0.22	TNFRSF25	tumor necrosis factor receptor superfamily, member 25	5342	0.12
chr18_22045724_22045875	0.22	HRH4	histamine receptor H4	5106	0.18
chr14_99701823_99701974	0.22	AL109767.1		27387	0.19
chr2_175456254_175456405	0.22	WIPF1	WAS/WASL interacting protein family, member 1	6012	0.19
chr7_26192485_26193339	0.22	NFE2L3	nuclear factor, erythroid 2-like 3	1052	0.53
chr9_274295_274630	0.22	DOCK8	dedicator of cytokinesis 8	1392	0.34
chrX_129218649_129218800	0.22	ELF4	E74-like factor 4 (ets domain transcription factor)	25612	0.18
chr15_69074948_69075145	0.21	ENSG00000265195	.	19218	0.22
chr1_169679248_169679951	0.21	SELL	selectin L	1240	0.48
chr9_34957337_34957488	0.20	KIAA1045	KIAA1045	72	0.97
chr18_60965137_60965288	0.20	RP11-28F1.2		16103	0.17
chr15_75080868_75081404	0.20	ENSG00000264386	.	38	0.76
chr22_27067492_27067685	0.20	CRYBA4	crystallin, beta A4	49660	0.13
chr3_141129590_141129741	0.20	ZBTB38	zinc finger and BTB domain containing 38	8005	0.24
chr17_73341947_73342237	0.20	RP11-16C1.3		1606	0.24
chr17_75878240_75878391	0.20	FLJ45079		344	0.91
chr17_58602582_58603600	0.20	APPBP2	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	393	0.59
chr2_192014047_192014198	0.20	STAT4	signal transducer and activator of transcription 4	1575	0.44
chr15_101786887_101787230	0.19	CHSY1	chondroitin sulfate synthase 1	5079	0.19
chr19_44123855_44124353	0.19	ZNF428	zinc finger protein 428	78	0.93
chr1_211780216_211780378	0.19	RP11-359E8.5		23230	0.15
chr7_138729622_138729773	0.19	ZC3HAV1L	zinc finger CCCH-type, antiviral 1-like	8922	0.21
chr2_233940706_233940970	0.19	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	15649	0.18
chr7_31851936_31852087	0.19	ENSG00000223070	.	18149	0.28
chr6_35570444_35570718	0.19	ENSG00000212579	.	49014	0.11
chr17_8801498_8801803	0.19	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	13174	0.21
chr10_11218203_11218399	0.19	RP3-323N1.2		4962	0.24
chr19_54873446_54873661	0.19	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	997	0.38
chr1_185663326_185663550	0.19	HMCN1	hemicentin 1	40245	0.17
chr2_182176845_182176996	0.19	ENSG00000266705	.	6541	0.33
chr3_151027973_151028124	0.19	GPR87	G protein-coupled receptor 87	6692	0.18
chr19_6801414_6802010	0.19	VAV1	vav 1 guanine nucleotide exchange factor	17583	0.13
chr20_52370448_52370599	0.18	ENSG00000238468	.	85226	0.09
chr10_14227081_14227239	0.18	RP11-397C18.2		110877	0.06
chrX_48776392_48776920	0.18	PIM2	pim-2 oncogene	355	0.76
chr19_47378667_47378818	0.18	AP2S1	adaptor-related protein complex 2, sigma 1 subunit	24493	0.14
chr1_29253817_29254129	0.18	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12882	0.18
chr14_73885671_73885822	0.18	NUMB	numb homolog (Drosophila)	8967	0.19
chr1_206729975_206731239	0.18	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	114	0.96
chr3_3214293_3214763	0.18	CRBN	cereblon	6830	0.19
chr14_35306917_35307068	0.18	ENSG00000251726	.	7574	0.17
chr8_66748492_66748643	0.18	PDE7A	phosphodiesterase 7A	2416	0.41
chr3_197875188_197875339	0.18	AC073135.3		38186	0.14
chr18_45018917_45019068	0.18	ENSG00000266582	.	112125	0.07
chr14_22747947_22748098	0.18	ENSG00000238634	.	137135	0.04
chr15_100050578_100050729	0.17	AC015660.1	HCG1993240; Serologically defined breast cancer antigen NY-BR-40; Uncharacterized protein	12075	0.22
chr11_9714574_9714725	0.17	ENSG00000201564	.	12178	0.18
chr2_230198282_230198433	0.17	PID1	phosphotyrosine interaction domain containing 1	62356	0.14
chr19_18507804_18508682	0.17	LRRC25	leucine rich repeat containing 25	178	0.89
chr19_16461941_16462107	0.17	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	10740	0.14
chr2_120687963_120688114	0.17	PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	686	0.74
chrX_1640522_1640673	0.17	P2RY8	purinergic receptor P2Y, G-protein coupled, 8	15403	0.2
chr2_198143570_198143721	0.17	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	23598	0.16
chr12_79960142_79960293	0.17	PAWR	PRKC, apoptosis, WT1, regulator	30097	0.18
chr2_113945705_113945856	0.17	PSD4	pleckstrin and Sec7 domain containing 4	8077	0.14
chrY_1590520_1590671	0.17	NA	NA	> 10⁶	NA
chr1_236056952_236057103	0.17	LYST	lysosomal trafficking regulator	10155	0.17
chr7_37448490_37448719	0.17	ENSG00000200113	.	10627	0.2
chr1_19789578_19789845	0.17	CAPZB	capping protein (actin filament) muscle Z-line, beta	20868	0.15
chr2_158977628_158977779	0.17	UPP2-IT1	UPP2 intronic transcript 1 (non-protein coding)	6766	0.22
chr11_121365458_121365609	0.17	RP11-730K11.1		41811	0.18
chr13_46750556_46750707	0.17	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	5828	0.17
chr3_172235814_172236037	0.16	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	5340	0.27
chr2_198064690_198065196	0.16	ANKRD44	ankyrin repeat domain 44	2181	0.29
chr10_59856470_59856621	0.16	ENSG00000238970	.	141976	0.05
chr7_36327271_36327770	0.16	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	9233	0.18
chr11_121298288_121298439	0.16	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	24549	0.21
chr7_25902012_25902163	0.16	ENSG00000199085	.	87519	0.1
chr4_35416147_35416298	0.16	ENSG00000206665	.	81298	0.12
chr8_90031831_90031982	0.16	RP11-586K2.1		319386	0.01
chr1_167059294_167059481	0.16	GPA33	glycoprotein A33 (transmembrane)	481	0.77
chr7_2550958_2551215	0.16	LFNG	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	1077	0.47
chr11_128595669_128596120	0.16	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	29976	0.16
chr14_106471583_106471884	0.16	IGHV1-3	immunoglobulin heavy variable 1-3	10	0.91
chr17_17603690_17604249	0.16	RAI1	retinoic acid induced 1	18160	0.17
chr6_70219788_70219939	0.16	ENSG00000265362	.	111402	0.07
chr7_7960072_7960471	0.16	ENSG00000201747	.	14121	0.18
chr2_201985007_201985268	0.16	CFLAR	CASP8 and FADD-like apoptosis regulator	1923	0.24
chr6_90066974_90067553	0.16	UBE2J1	ubiquitin-conjugating enzyme E2, J1	4696	0.23
chr10_97154601_97154752	0.15	SORBS1	sorbin and SH3 domain containing 1	20776	0.25
chr1_36270069_36270220	0.15	AGO4	argonaute RISC catalytic component 4	3629	0.22
chr1_15342375_15342526	0.15	KAZN	kazrin, periplakin interacting protein	70035	0.12
chrX_12989756_12990021	0.15	TMSB4X	thymosin beta 4, X-linked	3339	0.29
chr6_16687583_16687734	0.15	RP1-151F17.1		73711	0.11
chr3_146258052_146258203	0.15	PLSCR1	phospholipid scramblase 1	4181	0.23
chr22_36805845_36806656	0.15	MYH9	myosin, heavy chain 9, non-muscle	22187	0.14
chr20_49073623_49073774	0.15	ENSG00000244376	.	27678	0.17
chr6_170604225_170605407	0.15	FAM120B	family with sequence similarity 120B	407	0.83
chr12_57636595_57636960	0.15	NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	2302	0.16
chr14_51280034_51280250	0.15	RP11-286O18.1		8456	0.15
chr1_161523849_161524000	0.15	RP11-5K23.5		2944	0.16
chr6_42513326_42513477	0.15	UBR2	ubiquitin protein ligase E3 component n-recognin 2	18399	0.19
chr2_68995729_68995971	0.15	ARHGAP25	Rho GTPase activating protein 25	6083	0.26
chr14_73931285_73931436	0.15	ENSG00000251393	.	2231	0.24
chr1_25887785_25888064	0.15	LDLRAP1	low density lipoprotein receptor adaptor protein 1	17853	0.19
chr4_55809328_55809479	0.15	ENSG00000264332	.	67696	0.11
chr1_9711350_9712072	0.15	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	79	0.97
chr8_82066026_82066177	0.15	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	41798	0.19
chr3_39006420_39006571	0.15	SCN11A	sodium channel, voltage-gated, type XI, alpha subunit	14443	0.19
chr13_50810191_50810488	0.15	ENSG00000221198	.	127034	0.05
chr8_62604897_62605048	0.15	ASPH	aspartate beta-hydroxylase	2564	0.34
chr7_133116374_133116525	0.15	EXOC4	exocyst complex component 4	144767	0.05
chr11_40034818_40034969	0.15	ENSG00000221804	.	151749	0.04
chr18_9559122_9559273	0.15	RP11-881L2.1		28187	0.13
chr1_25889724_25889930	0.14	LDLRAP1	low density lipoprotein receptor adaptor protein 1	19756	0.18
chr11_47386705_47386856	0.14	MYBPC3	myosin binding protein C, cardiac	12527	0.09
chr6_43214536_43215130	0.14	TTBK1	tau tubulin kinase 1	894	0.48
chr1_221927643_221927794	0.14	DUSP10	dual specificity phosphatase 10	12200	0.29
chr20_33732566_33732717	0.14	EDEM2	ER degradation enhancer, mannosidase alpha-like 2	318	0.85
chr12_76658709_76658860	0.14	ENSG00000223273	.	50747	0.15
chr16_28235213_28235364	0.14	XPO6	exportin 6	12047	0.18
chr4_2939568_2939719	0.14	NOP14-AS1	NOP14 antisense RNA 1	265	0.88
chr9_97121768_97121919	0.14	HIATL1	hippocampus abundant transcript-like 1	14990	0.2
chr14_61793464_61793615	0.14	PRKCH	protein kinase C, eta	92	0.97
chr11_48041704_48041855	0.14	AC103828.1		4372	0.25
chr16_3265391_3265542	0.14	OR1F1	olfactory receptor, family 1, subfamily F, member 1	11219	0.1
chr16_50874988_50875494	0.14	ENSG00000199771	.	28245	0.15
chr14_35754560_35754711	0.14	ENSG00000265530	.	6057	0.23
chr20_55550076_55550227	0.14	ENSG00000251772	.	24992	0.22
chr15_52023462_52024365	0.14	LYSMD2	LysM, putative peptidoglycan-binding, domain containing 2	6405	0.15
chr1_161605235_161605386	0.14	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	3557	0.15
chr6_130848326_130848477	0.14	ENSG00000202438	.	46856	0.17
chr7_38392270_38392581	0.14	AMPH	amphiphysin	110288	0.07
chr1_235120289_235120440	0.14	ENSG00000239690	.	80431	0.1
chr3_172240144_172241280	0.14	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	553	0.83
chr8_141607200_141607468	0.14	AGO2	argonaute RISC catalytic component 2	8653	0.24
chrX_109351614_109351783	0.14	ENSG00000265584	.	26352	0.2
chr5_125785966_125786206	0.14	GRAMD3	GRAM domain containing 3	11951	0.22
chr20_48448748_48448899	0.14	ENSG00000252123	.	4294	0.19
chr12_15102775_15102926	0.14	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	779	0.6
chr17_40425804_40425955	0.14	AC003104.1		1178	0.32
chr16_17510234_17510944	0.13	XYLT1	xylosyltransferase I	54149	0.18
chr1_206900182_206900333	0.13	ENSG00000199349	.	21180	0.14
chr18_13465441_13465744	0.13	LDLRAD4	low density lipoprotein receptor class A domain containing 4	578	0.59
chr1_198896471_198896622	0.13	ENSG00000207759	.	68264	0.12
chr2_175357999_175358525	0.13	GPR155	G protein-coupled receptor 155	6440	0.21
chr1_81935804_81935955	0.13	RP5-837I24.6		34905	0.21
chr8_129289122_129289410	0.13	ENSG00000201782	.	56516	0.16
chr18_56307433_56307584	0.13	ALPK2	alpha-kinase 2	11319	0.15
chr17_76714885_76715036	0.13	CYTH1	cytohesin 1	1853	0.36
chr1_161154335_161154531	0.13	B4GALT3	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	7146	0.07
chr2_216922950_216923179	0.13	PECR	peroxisomal trans-2-enoyl-CoA reductase	23475	0.15
chr2_198006679_198006830	0.13	ANKRD44	ankyrin repeat domain 44	5874	0.27
chr15_101792013_101793187	0.13	CHSY1	chondroitin sulfate synthase 1	463	0.8
chr8_49416567_49416718	0.13	RP11-770E5.1		47485	0.19
chr7_130643743_130643906	0.13	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	25044	0.22
chr13_111108512_111108663	0.13	COL4A2-AS2	COL4A2 antisense RNA 2	7047	0.22
chr10_73512307_73512458	0.13	C10orf54	chromosome 10 open reading frame 54	5005	0.22
chr11_14666941_14667162	0.13	PDE3B	phosphodiesterase 3B, cGMP-inhibited	1674	0.36
chr8_55064954_55065105	0.13	ENSG00000251835	.	413	0.86
chr4_90222893_90223044	0.13	GPRIN3	GPRIN family member 3	6193	0.32
chr1_198651611_198651863	0.13	RP11-553K8.5		15547	0.24
chr19_6890241_6890675	0.13	EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	2868	0.21
chrX_147462452_147462756	0.13	AC002368.4		119531	0.06
chr3_45985242_45985393	0.13	CXCR6	chemokine (C-X-C motif) receptor 6	353	0.85
chr8_21776103_21776686	0.13	XPO7	exportin 7	786	0.64
chrX_118751905_118752056	0.13	NKRF	NFKB repressing factor	12122	0.15
chr6_11986707_11986858	0.13	RP11-456H18.1		5463	0.27
chr7_75085913_75086064	0.13	POM121C	POM121 transmembrane nucleoporin C	13995	0.12
chr2_168252602_168252753	0.13	XIRP2	xin actin-binding repeat containing 2	208884	0.03
chr3_53742016_53742167	0.12	CACNA1D	calcium channel, voltage-dependent, L type, alpha 1D subunit	41016	0.16
chr12_98912505_98912656	0.12	TMPO-AS1	TMPO antisense RNA 1	2380	0.2
chr14_52778923_52779116	0.12	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	2004	0.41
chr11_23251355_23251506	0.12	ENSG00000264478	.	241829	0.02
chr3_39302441_39302592	0.12	CX3CR1	chemokine (C-X3-C motif) receptor 1	19009	0.19
chr1_56111785_56112048	0.12	ENSG00000272051	.	161271	0.04
chr5_32583768_32584065	0.12	SUB1	SUB1 homolog (S. cerevisiae)	1689	0.49
chr14_99702038_99702570	0.12	AL109767.1		26981	0.19
chr6_15882568_15882719	0.12	DTNBP1	dystrobrevin binding protein 1	219370	0.02
chr2_32489606_32489792	0.12	NLRC4	NLR family, CARD domain containing 4	250	0.92
chr12_125405765_125405916	0.12	UBC	ubiquitin C	3926	0.19
chr1_181050920_181051071	0.12	IER5	immediate early response 5	6643	0.23

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU2F2_POU3F1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.3	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.2	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0061687	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0051832	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.1	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.0	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.1	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.0	GO:0009648	photoperiodism(GO:0009648)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.2	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.0	GO:0070574	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.0	GO:0002885	positive regulation of hypersensitivity(GO:0002885)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.1	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0072577	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.0	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0016045	detection of bacterium(GO:0016045)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0006244	pyrimidine nucleotide catabolic process(GO:0006244)
0.0	0.0	GO:0045409	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0042119	granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0	0.0	GO:0046643	regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0060134	prepulse inhibition(GO:0060134)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.1	GO:0001891	phagocytic cup(GO:0001891)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.7	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.0	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.0	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.0	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0046870	cadmium ion binding(GO:0046870)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.3	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.3	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.4	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.2	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.3	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle