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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for POU3F3_POU3F4

Z-value: 1.75

Motif logo

Transcription factors associated with POU3F3_POU3F4

Gene Symbol	Gene ID	Gene Info
POU3F3 Ensembl NCBI GeneCards UniProt	ENSG00000198914.2	POU3F3
POU3F4 Ensembl NCBI GeneCards UniProt	ENSG00000196767.4	POU3F4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
POU3F3	chr2_105471048_105471431	730	0.471155	-0.55	1.3e-01	Click!
POU3F3	chr2_105471431_105471582	463	0.684630	-0.53	1.4e-01	Click!
POU3F3	chr2_105473621_105473772	1727	0.260320	0.52	1.5e-01	Click!
POU3F3	chr2_105476021_105476172	4127	0.156010	-0.51	1.6e-01	Click!
POU3F3	chr2_105474864_105475015	2970	0.179506	-0.33	3.8e-01	Click!
POU3F4	chrX_82763168_82763319	26	0.962329	-0.51	1.6e-01	Click!
POU3F4	chrX_82762361_82762512	833	0.620699	-0.41	2.8e-01	Click!
POU3F4	chrX_82763349_82763500	155	0.908200	-0.36	3.4e-01	Click!
POU3F4	chrX_82762744_82762895	450	0.798138	-0.29	4.5e-01	Click!

Activity of the POU3F3_POU3F4 motif across conditions

Conditions sorted by the z-value of the POU3F3_POU3F4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_55863175_55863444	1.01	RP11-718I15.1		381	0.52
chr18_32287572_32287755	0.80	DTNA	dystrobrevin, alpha	2585	0.38
chr6_46375502_46375653	0.67	RCAN2	regulator of calcineurin 2	49136	0.16
chr18_48718913_48719435	0.64	MEX3C	mex-3 RNA binding family member C	3955	0.31
chr4_177254207_177254358	0.63	RP11-87F15.2		12673	0.21
chr1_112603472_112603623	0.61	KCND3	potassium voltage-gated channel, Shal-related subfamily, member 3	71770	0.11
chr7_51866473_51866624	0.61	ENSG00000242650	.	82194	0.12
chr12_85410552_85410703	0.60	TSPAN19	tetraspanin 19	747	0.74
chr3_174059484_174059635	0.58	NAALADL2	N-acetylated alpha-linked acidic dipeptidase-like 2	99218	0.09
chr19_52832897_52833072	0.57	ZNF610	zinc finger protein 610	6514	0.11
chr10_119119895_119120046	0.56	ENSG00000222197	.	2103	0.35
chr13_70755828_70755979	0.55	KLHL1	kelch-like family member 1	73312	0.12
chr2_191518131_191518282	0.55	NAB1	NGFI-A binding protein 1 (EGR1 binding protein 1)	245	0.94
chr10_52364321_52364493	0.55	ENSG00000238523	.	13935	0.15
chr12_39821314_39821465	0.54	KIF21A	kinesin family member 21A	15383	0.23
chr4_83787091_83787242	0.52	SEC31A	SEC31 homolog A (S. cerevisiae)	918	0.55
chr14_105479768_105479974	0.51	CDCA4	cell division cycle associated 4	7526	0.16
chr7_155168058_155168209	0.50	AC008060.7	HCG2000720; Hypothetical gene supported by AK054822; Uncharacterized protein	6638	0.18
chr10_53873012_53873163	0.49	PRKG1	protein kinase, cGMP-dependent, type I	66550	0.14
chr14_73885671_73885822	0.48	NUMB	numb homolog (Drosophila)	8967	0.19
chr6_91424739_91424890	0.47	MAP3K7	mitogen-activated protein kinase kinase kinase 7	128050	0.06
chr3_164285782_164285933	0.46	ENSG00000221755	.	226728	0.02
chr11_115065010_115065166	0.46	CADM1	cell adhesion molecule 1	46612	0.18
chr6_41604382_41604533	0.46	MDFI	MyoD family inhibitor	163	0.94
chr14_29242746_29242955	0.46	C14orf23	chromosome 14 open reading frame 23	849	0.55
chr1_93221952_93222251	0.46	EVI5	ecotropic viral integration site 5	35850	0.13
chr2_97452820_97452971	0.46	CNNM4	cyclin M4	1427	0.34
chr1_186415843_186415994	0.46	PDC	phosducin	281	0.89
chrX_26102260_26102411	0.46	MAGEB18	melanoma antigen family B, 18	54125	0.17
chr4_166405048_166405199	0.45	CPE	carboxypeptidase E	65745	0.13
chr2_202313137_202313288	0.45	TRAK2	trafficking protein, kinesin binding 2	3011	0.22
chr1_93443435_93443586	0.45	ENSG00000239710	.	2830	0.16
chr10_118924530_118925015	0.44	ENSG00000266782	.	2513	0.25
chr1_101587818_101587969	0.44	ENSG00000252765	.	10816	0.2
chr10_127685162_127685313	0.44	FANK1	fibronectin type III and ankyrin repeat domains 1	1251	0.5
chr7_87986606_87986757	0.43	STEAP4	STEAP family member 4	50475	0.15
chr5_114866886_114867037	0.43	FEM1C	fem-1 homolog c (C. elegans)	13630	0.22
chr3_173220593_173220744	0.43	NLGN1	neuroligin 1	81677	0.12
chr18_53089837_53090372	0.43	TCF4	transcription factor 4	361	0.89
chr2_181570330_181570481	0.42	ENSG00000264976	.	88472	0.1
chr4_126244718_126245045	0.42	FAT4	FAT atypical cadherin 4	7327	0.29
chr10_63979683_63979834	0.42	RTKN2	rhotekin 2	16264	0.26
chr8_59762363_59762514	0.42	ENSG00000201231	.	35327	0.22
chr17_68401721_68401883	0.42	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	236126	0.02
chr1_21409721_21409872	0.42	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	5905	0.27
chr2_43986075_43986259	0.42	ENSG00000252490	.	13322	0.19
chr1_51440088_51440239	0.41	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	4547	0.24
chr4_95175515_95175666	0.41	SMARCAD1	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	1145	0.65
chr3_194592423_194592920	0.41	FAM43A	family with sequence similarity 43, member A	186049	0.02
chr11_27335139_27335290	0.41	CCDC34	coiled-coil domain containing 34	49567	0.16
chr12_133770634_133770785	0.40	ZNF268	zinc finger protein 268	2626	0.19
chr4_22971290_22971441	0.40	GPR125	G protein-coupled receptor 125	453688	0.01
chr2_175709747_175709898	0.40	CHN1	chimerin 1	1311	0.54
chr7_97282168_97282319	0.40	ENSG00000199475	.	53671	0.15
chr13_74159314_74159465	0.40	ENSG00000206697	.	358105	0.01
chr3_29377379_29377667	0.40	ENSG00000216169	.	33389	0.18
chr4_161638888_161639039	0.40	ENSG00000221362	.	286147	0.01
chr8_70622919_70623070	0.40	RP11-102F4.2		2631	0.31
chr6_139454805_139454996	0.40	HECA	headcase homolog (Drosophila)	1349	0.54
chr20_34459115_34459914	0.39	ENSG00000201221	.	16067	0.13
chr3_60921693_60921844	0.39	ENSG00000212211	.	79491	0.12
chr3_81724848_81724999	0.39	GBE1	glucan (1,4-alpha-), branching enzyme 1	67857	0.14
chr10_3977780_3978372	0.39	KLF6	Kruppel-like factor 6	150603	0.04
chr2_208339912_208340104	0.39	CREB1	cAMP responsive element binding protein 1	54453	0.13
chr17_67056652_67056803	0.39	ABCA9	ATP-binding cassette, sub-family A (ABC1), member 9	320	0.9
chr3_79030262_79030413	0.39	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	37357	0.2
chr5_127036963_127037114	0.38	CTC-548H10.2		37317	0.19
chr10_128613788_128613939	0.38	ENSG00000202487	.	4487	0.28
chrX_136337073_136337224	0.38	GPR101	G protein-coupled receptor 101	223315	0.02
chr3_38247873_38248024	0.38	OXSR1	oxidative stress responsive 1	40952	0.12
chr10_90753077_90753312	0.38	ACTA2	actin, alpha 2, smooth muscle, aorta	2047	0.24
chr14_26016058_26016209	0.38	ENSG00000212270	.	259785	0.02
chr13_80614475_80614626	0.38	SPRY2	sprouty homolog 2 (Drosophila)	299244	0.01
chr9_89574254_89574405	0.38	GAS1	growth arrest-specific 1	12225	0.31
chr1_240669972_240670123	0.38	AL646016.1	Uncharacterized protein	26543	0.18
chr6_100909122_100909273	0.38	SIM1	single-minded family bHLH transcription factor 1	2356	0.39
chr15_38549534_38549685	0.37	SPRED1	sprouty-related, EVH1 domain containing 1	4227	0.36
chr7_105432133_105432284	0.37	ATXN7L1	ataxin 7-like 1	84715	0.1
chr1_189197213_189197364	0.37	ENSG00000252553	.	438098	0.01
chr5_104399872_104400023	0.37	ENSG00000252881	.	283857	0.01
chr10_70096270_70096993	0.37	PBLD	phenazine biosynthesis-like protein domain containing	3825	0.2
chr3_156405026_156405177	0.37	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	6146	0.24
chr18_29220350_29220501	0.37	ENSG00000252379	.	28916	0.13
chr8_131954085_131954236	0.37	RP11-737F9.1		6505	0.26
chr2_216298275_216298426	0.37	FN1	fibronectin 1	2440	0.3
chrY_23414698_23414849	0.37	CYorf17	chromosome Y open reading frame 17	133473	0.05
chr10_6780355_6780830	0.37	PRKCQ	protein kinase C, theta	158329	0.04
chr15_50151604_50151755	0.37	ATP8B4	ATPase, class I, type 8B, member 4	17213	0.21
chr4_167130026_167130177	0.37	ENSG00000266254	.	18816	0.28
chr5_158301830_158301981	0.37	CTD-2363C16.1		108109	0.07
chr14_81453709_81453897	0.36	CEP128	centrosomal protein 128kDa	27955	0.21
chr14_38888998_38889149	0.36	CLEC14A	C-type lectin domain family 14, member A	163499	0.04
chr5_168003477_168003628	0.36	PANK3	pantothenate kinase 3	2803	0.26
chr10_63402177_63402609	0.36	C10orf107	chromosome 10 open reading frame 107	20326	0.24
chr4_123719562_123719754	0.36	FGF2	fibroblast growth factor 2 (basic)	28205	0.16
chr10_19314438_19314589	0.36	MALRD1	MAM and LDL receptor class A domain containing 1	178266	0.03
chr13_99629621_99629906	0.36	DOCK9	dedicator of cytokinesis 9	481	0.85
chr14_45559377_45559745	0.35	ENSG00000212615	.	2115	0.2
chr5_67577391_67577649	0.35	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	1385	0.58
chr8_69986403_69986554	0.35	ENSG00000238808	.	36331	0.24
chr6_102835538_102835689	0.35	GRIK2	glutamate receptor, ionotropic, kainate 2	569368	0.0
chr6_143256936_143257087	0.35	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	9327	0.26
chr3_33061626_33061777	0.35	CCR4	chemokine (C-C motif) receptor 4	68635	0.09
chr15_80361249_80361400	0.35	ZFAND6	zinc finger, AN1-type domain 6	3582	0.28
chr2_29340749_29340907	0.35	CLIP4	CAP-GLY domain containing linker protein family, member 4	233	0.92
chr1_164290160_164290619	0.35	ENSG00000199849	.	30121	0.25
chr16_63376236_63376387	0.35	RP11-96H17.3		275417	0.02
chr6_13505550_13505701	0.35	GFOD1	glucose-fructose oxidoreductase domain containing 1	17731	0.14
chr7_83098669_83098820	0.34	AC079799.2		114274	0.07
chr7_136910239_136910390	0.34	hsa-mir-490	hsa-mir-490	43460	0.18
chr15_35950174_35950564	0.34	DPH6	diphthamine biosynthesis 6	111976	0.07
chrX_45625887_45626164	0.34	ENSG00000207725	.	19495	0.22
chr14_99712277_99712758	0.34	AL109767.1		16768	0.21
chr15_59344636_59344787	0.34	RNF111	ring finger protein 111	20888	0.16
chr10_55152331_55152482	0.33	ENSG00000252161	.	65551	0.15
chr18_29888572_29888839	0.33	RP11-344B2.2		21305	0.16
chr4_117414615_117414766	0.33	MTRNR2L13	MT-RNR2-like 13 (pseudogene)	194674	0.03
chr21_38831812_38831963	0.33	DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	29200	0.2
chr21_35304396_35305066	0.33	LINC00649	long intergenic non-protein coding RNA 649	1213	0.41
chr4_39570973_39571124	0.33	UGDH	UDP-glucose 6-dehydrogenase	41117	0.11
chr1_209558665_209558816	0.33	ENSG00000230937	.	46738	0.19
chr6_125364944_125365095	0.33	RNF217	ring finger protein 217	4339	0.31
chr12_118472279_118472430	0.33	RFC5	replication factor C (activator 1) 5, 36.5kDa	17820	0.18
chr5_172286846_172286997	0.33	ERGIC1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	25507	0.16
chr1_243687933_243688084	0.33	RP11-269F20.1		20826	0.27
chr8_41277096_41277247	0.33	ENSG00000238936	.	7003	0.23
chrX_31453419_31453570	0.33	ENSG00000252903	.	87185	0.1
chr1_182991327_182991478	0.33	LAMC1	laminin, gamma 1 (formerly LAMB2)	1193	0.49
chr5_110560941_110561277	0.33	CAMK4	calcium/calmodulin-dependent protein kinase IV	1325	0.51
chr2_106372613_106372764	0.33	NCK2	NCK adaptor protein 2	10500	0.29
chr1_38510289_38510696	0.32	POU3F1	POU class 3 homeobox 1	1958	0.27
chr2_230148069_230148220	0.32	PID1	phosphotyrosine interaction domain containing 1	12143	0.27
chr4_110217881_110218141	0.32	COL25A1	collagen, type XXV, alpha 1	5512	0.3
chr7_157225535_157225734	0.32	AC006372.6		80354	0.09
chr12_41084046_41084197	0.32	CNTN1	contactin 1	2123	0.46
chr4_68593746_68593897	0.32	UBA6-AS1	UBA6 antisense RNA 1 (head to head)	4041	0.2
chr5_30785800_30785951	0.32	CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	407982	0.01
chr10_60580536_60580825	0.32	BICC1	bicaudal C homolog 1 (Drosophila)	27385	0.23
chr12_111003570_111003721	0.32	PPTC7	PTC7 protein phosphatase homolog (S. cerevisiae)	17480	0.14
chr14_38613607_38613758	0.32	CTD-2058B24.2		49804	0.14
chr2_201248196_201249000	0.32	ENSG00000264798	.	3300	0.23
chr6_37483764_37484117	0.32	CCDC167	coiled-coil domain containing 167	16242	0.19
chr10_75912778_75912929	0.32	ADK	adenosine kinase	1866	0.31
chr2_213962198_213962349	0.32	IKZF2	IKAROS family zinc finger 2 (Helios)	51080	0.16
chr1_8741272_8741496	0.32	RERE	arginine-glutamic acid dipeptide (RE) repeats	21894	0.23
chr2_29850591_29850818	0.31	ENSG00000242699	.	53485	0.16
chr3_79625949_79626100	0.31	ENSG00000216116	.	7810	0.3
chr4_151600832_151601026	0.31	ENSG00000221235	.	39911	0.19
chr18_20558047_20558453	0.31	RBBP8	retinoblastoma binding protein 8	9445	0.15
chr18_70644965_70645116	0.31	NETO1	neuropilin (NRP) and tolloid (TLL)-like 1	109856	0.07
chr12_113797502_113797653	0.31	SLC8B1	solute carrier family 8 (sodium/lithium/calcium exchanger), member B1	279	0.85
chr1_192547268_192547419	0.31	RGS1	regulator of G-protein signaling 1	2440	0.31
chr6_14127798_14127949	0.31	CD83	CD83 molecule	10001	0.25
chr5_125703700_125704120	0.31	GRAMD3	GRAM domain containing 3	3095	0.37
chr2_32940890_32941041	0.31	TTC27	tetratricopeptide repeat domain 27	37020	0.2
chr21_35266767_35266918	0.31	ATP5O	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	14557	0.14
chr2_97593731_97594362	0.31	ENSG00000252845	.	28506	0.12
chr2_110376280_110376431	0.31	SOWAHC	sosondowah ankyrin repeat domain family member C	4444	0.21
chr1_25060751_25060902	0.31	CLIC4	chloride intracellular channel 4	11022	0.2
chr6_12280277_12280428	0.31	EDN1	endothelin 1	10244	0.3
chr20_53950807_53950958	0.31	ENSG00000252089	.	474531	0.01
chr9_33446798_33447442	0.31	AQP3	aquaporin 3 (Gill blood group)	489	0.76
chr1_76788853_76789004	0.31	ST6GALNAC3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	248524	0.02
chr3_121373349_121373500	0.31	ENSG00000243544	.	281	0.82
chr18_13275881_13276032	0.31	LDLRAD4	low density lipoprotein receptor class A domain containing 4	2146	0.32
chr4_110223153_110224430	0.31	COL25A1	collagen, type XXV, alpha 1	8	0.99
chr12_61131831_61131982	0.31	ENSG00000251822	.	374303	0.01
chr7_79063706_79063857	0.31	ENSG00000234456	.	18417	0.22
chr2_40049399_40049550	0.31	SLC8A1-AS1	SLC8A1 antisense RNA 1	35881	0.19
chrX_131763564_131763715	0.31	HS6ST2-AS1	HS6ST2 antisense RNA 1	38031	0.17
chr6_106549276_106549427	0.30	RP1-134E15.3		1336	0.46
chr3_24225373_24225524	0.30	THRB	thyroid hormone receptor, beta	18362	0.28
chr5_165288349_165288500	0.30	ENSG00000252794	.	251978	0.02
chr15_24112084_24112235	0.30	ENSG00000206616	.	89469	0.09
chr22_46462327_46462478	0.30	RP6-109B7.4		3369	0.13
chr16_75836248_75836399	0.30	ENSG00000199299	.	58732	0.12
chr1_154358065_154358416	0.30	IL6R	interleukin 6 receptor	19429	0.11
chr4_75224942_75225093	0.30	EREG	epiregulin	5843	0.21
chr13_79182716_79183828	0.30	POU4F1	POU class 4 homeobox 1	5599	0.19
chr7_25902294_25902669	0.30	ENSG00000199085	.	87125	0.1
chr4_20261154_20261305	0.30	SLIT2	slit homolog 2 (Drosophila)	4686	0.35
chr13_82572321_82572472	0.29	ENSG00000222486	.	732514	0.0
chr16_4146823_4146974	0.29	ADCY9	adenylate cyclase 9	17129	0.21
chr8_67524217_67524427	0.29	MYBL1	v-myb avian myeloblastosis viral oncogene homolog-like 1	820	0.61
chr7_54625683_54625834	0.29	GS1-18A18.1		1095	0.57
chr12_126874132_126874719	0.29	TMEM132B	transmembrane protein 132B	767383	0.0
chr5_100224849_100225000	0.29	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	13994	0.28
chr15_50977663_50977814	0.29	TRPM7	transient receptor potential cation channel, subfamily M, member 7	1230	0.45
chr3_107850710_107850861	0.29	CD47	CD47 molecule	40913	0.19
chrX_141646229_141646380	0.29	ENSG00000266319	.	48427	0.19
chr9_12772195_12772422	0.29	LURAP1L	leucine rich adaptor protein 1-like	2712	0.28
chr5_66445517_66445857	0.29	MAST4	microtubule associated serine/threonine kinase family member 4	7425	0.28
chr6_66722316_66722467	0.29	EYS	eyes shut homolog (Drosophila)	305273	0.01
chr10_60495190_60495341	0.29	BICC1	bicaudal C homolog 1 (Drosophila)	58030	0.16
chr12_78337025_78337244	0.29	NAV3	neuron navigator 3	22922	0.28
chr2_120041983_120042165	0.29	STEAP3-AS1	STEAP3 antisense RNA 1	35427	0.15
chr7_28133742_28133893	0.29	JAZF1	JAZF zinc finger 1	22514	0.2
chr12_55266839_55266990	0.29	MUCL1	mucin-like 1	18593	0.23
chr4_140808579_140808865	0.29	MAML3	mastermind-like 3 (Drosophila)	2484	0.4
chr9_123956593_123956744	0.29	RAB14	RAB14, member RAS oncogene family	7479	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU3F3_POU3F4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.1	0.4	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.1	0.4	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.1	0.4	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.3	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.2	GO:0010613	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.1	0.2	GO:0070295	renal water absorption(GO:0070295)
0.1	0.2	GO:0009822	alkaloid catabolic process(GO:0009822)
0.1	0.1	GO:0019049	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.2	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.1	0.4	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.1	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.1	0.1	GO:0060197	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.1	0.3	GO:0033084	regulation of immature T cell proliferation in thymus(GO:0033084)
0.1	0.3	GO:0010667	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1	0.3	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.1	0.2	GO:0016576	histone dephosphorylation(GO:0016576)
0.1	0.3	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.1	0.1	GO:0032674	interleukin-5 production(GO:0032634) regulation of interleukin-5 production(GO:0032674)
0.1	0.2	GO:0031223	auditory behavior(GO:0031223)
0.1	0.2	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1	0.2	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.1	0.2	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.3	GO:0034331	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.1	0.1	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.6	GO:0014037	Schwann cell differentiation(GO:0014037)
0.0	0.1	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0070254	mucus secretion(GO:0070254)
0.0	0.1	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.2	GO:0090218	positive regulation of lipid kinase activity(GO:0090218)
0.0	0.2	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0010159	specification of organ position(GO:0010159)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934)
0.0	0.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.3	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.2	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.2	GO:0055091	phospholipid homeostasis(GO:0055091)
0.0	0.0	GO:0060463	lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0	0.3	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.1	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.2	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.1	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.1	GO:1904251	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.1	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0	0.0	GO:0046532	regulation of photoreceptor cell differentiation(GO:0046532)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0003181	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.1	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.4	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.0	GO:0048520	positive regulation of behavior(GO:0048520)
0.0	0.1	GO:0006273	lagging strand elongation(GO:0006273)
0.0	0.3	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.4	GO:0042474	middle ear morphogenesis(GO:0042474)
0.0	0.0	GO:0032849	positive regulation of cellular pH reduction(GO:0032849)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0003214	cardiac left ventricle morphogenesis(GO:0003214)
0.0	0.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.4	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.0	GO:0002887	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.0	GO:0033025	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.6	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0045920	negative regulation of exocytosis(GO:0045920)
0.0	0.1	GO:0021873	forebrain neuroblast division(GO:0021873)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.2	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.2	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0055057	neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0	0.1	GO:0015742	alpha-ketoglutarate transport(GO:0015742)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.0	GO:0051284	negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.0	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.2	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.2	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0045780	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	0.1	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.0	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.0	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0031000	response to caffeine(GO:0031000)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.0	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.0	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.1	GO:0051894	positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0046337	phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0061117	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.1	GO:0001945	lymph vessel development(GO:0001945)
0.0	0.0	GO:0001743	optic placode formation(GO:0001743)
0.0	0.1	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.0	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.1	GO:0071800	podosome assembly(GO:0071800)
0.0	0.0	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.2	GO:0006949	syncytium formation(GO:0006949)
0.0	0.2	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0	0.1	GO:0048841	regulation of axon extension involved in axon guidance(GO:0048841)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0051963	regulation of synapse assembly(GO:0051963)
0.0	0.0	GO:0070977	organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0055075	potassium ion homeostasis(GO:0055075)
0.0	0.0	GO:0002911	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.0	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0021904	dorsal/ventral neural tube patterning(GO:0021904)
0.0	0.0	GO:0061213	positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0	0.0	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0060347	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.0	GO:2000400	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.2	GO:0000038	very long-chain fatty acid metabolic process(GO:0000038)
0.0	0.4	GO:0007602	phototransduction(GO:0007602)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.3	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.0	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.2	GO:0000737	DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309)
0.0	0.0	GO:0060117	auditory receptor cell development(GO:0060117)
0.0	0.0	GO:0060535	trachea morphogenesis(GO:0060439) trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0	0.1	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.0	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.0	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0021546	rhombomere development(GO:0021546)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.0	GO:0036315	cellular response to sterol(GO:0036315) cellular response to cholesterol(GO:0071397)
0.0	0.0	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0032119	sequestering of zinc ion(GO:0032119)
0.0	0.0	GO:0060457	negative regulation of digestive system process(GO:0060457)
0.0	0.0	GO:0090266	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.1	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.2	GO:0043488	regulation of mRNA stability(GO:0043488)
0.0	0.1	GO:0043113	receptor clustering(GO:0043113)
0.0	0.1	GO:0048240	sperm capacitation(GO:0048240)
0.0	0.0	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.0	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.0	GO:0032730	regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.0	GO:0032825	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.0	GO:0034244	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.0	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.1	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.0	GO:0019532	oxalate transport(GO:0019532)
0.0	0.4	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0	0.0	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0030325	adrenal gland development(GO:0030325)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.2	GO:0043259	laminin-10 complex(GO:0043259)
0.1	0.2	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.4	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.3	GO:0031941	filamentous actin(GO:0031941)
0.0	0.1	GO:0031045	dense core granule(GO:0031045)
0.0	0.2	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.2	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.2	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.4	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.2	GO:0043205	fibril(GO:0043205)
0.0	0.1	GO:0043256	laminin complex(GO:0043256)
0.0	0.1	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.0	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.1	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.0	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.2	GO:0000299	obsolete integral to membrane of membrane fraction(GO:0000299)
0.0	0.0	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.0	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.3	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0015254	glycerol channel activity(GO:0015254)
0.1	0.2	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.5	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.1	0.2	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.1	0.2	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.1	0.2	GO:0005113	patched binding(GO:0005113)
0.1	0.3	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.1	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.5	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.4	GO:0016595	glutamate binding(GO:0016595)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.3	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.2	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.2	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.2	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.2	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0031782	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.3	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.4	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.3	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.2	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.0	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.5	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.2	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.3	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.1	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.0	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.2	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.0	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.0	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.0	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.0	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.2	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.2	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.3	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.1	GO:0004083	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.4	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.2	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.0	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.0	GO:0034618	arginine binding(GO:0034618)
0.0	0.2	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.0	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.0	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.2	GO:0045296	cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.7	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.3	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.9	NABA COLLAGENS	Genes encoding collagen proteins
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.9	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.5	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.8	PID NOTCH PATHWAY	Notch signaling pathway
0.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.2	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.3	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	PID IL2 1PATHWAY	IL2-mediated signaling events
0.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	PID TCPTP PATHWAY	Signaling events mediated by TCPTP

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.6	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.3	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.3	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.2	REACTOME SIGNALLING BY NGF	Genes involved in Signalling by NGF
0.0	0.3	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.1	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.0	0.3	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.0	0.4	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.0	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.2	REACTOME PEPTIDE HORMONE BIOSYNTHESIS	Genes involved in Peptide hormone biosynthesis
0.0	0.5	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.0	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	0.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.2	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.0	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.0	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.1	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.0	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.3	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.2	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.1	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.3	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus