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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for POU3F3_POU3F4

Z-value: 1.75

Motif logo

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Transcription factors associated with POU3F3_POU3F4

Gene Symbol Gene ID Gene Info
POU3F3
ENSG00000198914.2 POU class 3 homeobox 3
POU3F4
ENSG00000196767.4 POU class 3 homeobox 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr2_105471048_105471431POU3F37300.471155-0.551.3e-01Click!
chr2_105471431_105471582POU3F34630.684630-0.531.4e-01Click!
chr2_105473621_105473772POU3F317270.2603200.521.5e-01Click!
chr2_105476021_105476172POU3F341270.156010-0.511.6e-01Click!
chr2_105474864_105475015POU3F329700.179506-0.333.8e-01Click!
chrX_82763168_82763319POU3F4260.962329-0.511.6e-01Click!
chrX_82762361_82762512POU3F48330.620699-0.412.8e-01Click!
chrX_82763349_82763500POU3F41550.908200-0.363.4e-01Click!
chrX_82762744_82762895POU3F44500.798138-0.294.5e-01Click!

Activity of the POU3F3_POU3F4 motif across conditions

Conditions sorted by the z-value of the POU3F3_POU3F4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr18_55863175_55863444 1.01 RP11-718I15.1
381
 0.52
chr18_32287572_32287755 0.80 DTNA
 dystrobrevin, alpha
 2585
 0.38
chr6_46375502_46375653 0.67 RCAN2
 regulator of calcineurin 2
 49136
 0.16
chr18_48718913_48719435 0.64 MEX3C
 mex-3 RNA binding family member C
 3955
 0.31
chr4_177254207_177254358 0.63 RP11-87F15.2
12673
 0.21
chr1_112603472_112603623 0.61 KCND3
 potassium voltage-gated channel, Shal-related subfamily, member 3
 71770
 0.11
chr7_51866473_51866624 0.61 ENSG00000242650
 .
 82194
 0.12
chr12_85410552_85410703 0.60 TSPAN19
 tetraspanin 19
 747
 0.74
chr3_174059484_174059635 0.58 NAALADL2
 N-acetylated alpha-linked acidic dipeptidase-like 2
 99218
 0.09
chr19_52832897_52833072 0.57 ZNF610
 zinc finger protein 610
 6514
 0.11
chr10_119119895_119120046 0.56 ENSG00000222197
 .
 2103
 0.35
chr13_70755828_70755979 0.55 KLHL1
 kelch-like family member 1
 73312
 0.12
chr2_191518131_191518282 0.55 NAB1
 NGFI-A binding protein 1 (EGR1 binding protein 1)
 245
 0.94
chr10_52364321_52364493 0.55 ENSG00000238523
 .
 13935
 0.15
chr12_39821314_39821465 0.54 KIF21A
 kinesin family member 21A
 15383
 0.23
chr4_83787091_83787242 0.52 SEC31A
 SEC31 homolog A (S. cerevisiae)
 918
 0.55
chr14_105479768_105479974 0.51 CDCA4
 cell division cycle associated 4
 7526
 0.16
chr7_155168058_155168209 0.50 AC008060.7
 HCG2000720; Hypothetical gene supported by AK054822; Uncharacterized protein
 6638
 0.18
chr10_53873012_53873163 0.49 PRKG1
 protein kinase, cGMP-dependent, type I
 66550
 0.14
chr14_73885671_73885822 0.48 NUMB
 numb homolog (Drosophila)
 8967
 0.19
chr6_91424739_91424890 0.47 MAP3K7
 mitogen-activated protein kinase kinase kinase 7
 128050
 0.06
chr3_164285782_164285933 0.46 ENSG00000221755
 .
 226728
 0.02
chr11_115065010_115065166 0.46 CADM1
 cell adhesion molecule 1
 46612
 0.18
chr6_41604382_41604533 0.46 MDFI
 MyoD family inhibitor
 163
 0.94
chr14_29242746_29242955 0.46 C14orf23
 chromosome 14 open reading frame 23
 849
 0.55
chr1_93221952_93222251 0.46 EVI5
 ecotropic viral integration site 5
 35850
 0.13
chr2_97452820_97452971 0.46 CNNM4
 cyclin M4
 1427
 0.34
chr1_186415843_186415994 0.46 PDC
 phosducin
 281
 0.89
chrX_26102260_26102411 0.46 MAGEB18
 melanoma antigen family B, 18
 54125
 0.17
chr4_166405048_166405199 0.45 CPE
 carboxypeptidase E
 65745
 0.13
chr2_202313137_202313288 0.45 TRAK2
 trafficking protein, kinesin binding 2
 3011
 0.22
chr1_93443435_93443586 0.45 ENSG00000239710
 .
 2830
 0.16
chr10_118924530_118925015 0.44 ENSG00000266782
 .
 2513
 0.25
chr1_101587818_101587969 0.44 ENSG00000252765
 .
 10816
 0.2
chr10_127685162_127685313 0.44 FANK1
 fibronectin type III and ankyrin repeat domains 1
 1251
 0.5
chr7_87986606_87986757 0.43 STEAP4
 STEAP family member 4
 50475
 0.15
chr5_114866886_114867037 0.43 FEM1C
 fem-1 homolog c (C. elegans)
 13630
 0.22
chr3_173220593_173220744 0.43 NLGN1
 neuroligin 1
 81677
 0.12
chr18_53089837_53090372 0.43 TCF4
 transcription factor 4
 361
 0.89
chr2_181570330_181570481 0.42 ENSG00000264976
 .
 88472
 0.1
chr4_126244718_126245045 0.42 FAT4
 FAT atypical cadherin 4
 7327
 0.29
chr10_63979683_63979834 0.42 RTKN2
 rhotekin 2
 16264
 0.26
chr8_59762363_59762514 0.42 ENSG00000201231
 .
 35327
 0.22
chr17_68401721_68401883 0.42 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
 236126
 0.02
chr1_21409721_21409872 0.42 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
 5905
 0.27
chr2_43986075_43986259 0.42 ENSG00000252490
 .
 13322
 0.19
chr1_51440088_51440239 0.41 CDKN2C
 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
 4547
 0.24
chr4_95175515_95175666 0.41 SMARCAD1
 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
 1145
 0.65
chr3_194592423_194592920 0.41 FAM43A
 family with sequence similarity 43, member A
 186049
 0.02
chr11_27335139_27335290 0.41 CCDC34
 coiled-coil domain containing 34
 49567
 0.16
chr12_133770634_133770785 0.40 ZNF268
 zinc finger protein 268
 2626
 0.19
chr4_22971290_22971441 0.40 GPR125
 G protein-coupled receptor 125
 453688
 0.01
chr2_175709747_175709898 0.40 CHN1
 chimerin 1
 1311
 0.54
chr7_97282168_97282319 0.40 ENSG00000199475
 .
 53671
 0.15
chr13_74159314_74159465 0.40 ENSG00000206697
 .
 358105
 0.01
chr3_29377379_29377667 0.40 ENSG00000216169
 .
 33389
 0.18
chr4_161638888_161639039 0.40 ENSG00000221362
 .
 286147
 0.01
chr8_70622919_70623070 0.40 RP11-102F4.2
2631
 0.31
chr6_139454805_139454996 0.40 HECA
 headcase homolog (Drosophila)
 1349
 0.54
chr20_34459115_34459914 0.39 ENSG00000201221
 .
 16067
 0.13
chr3_60921693_60921844 0.39 ENSG00000212211
 .
 79491
 0.12
chr3_81724848_81724999 0.39 GBE1
 glucan (1,4-alpha-), branching enzyme 1
 67857
 0.14
chr10_3977780_3978372 0.39 KLF6
 Kruppel-like factor 6
 150603
 0.04
chr2_208339912_208340104 0.39 CREB1
 cAMP responsive element binding protein 1
 54453
 0.13
chr17_67056652_67056803 0.39 ABCA9
 ATP-binding cassette, sub-family A (ABC1), member 9
 320
 0.9
chr3_79030262_79030413 0.39 ROBO1
 roundabout, axon guidance receptor, homolog 1 (Drosophila)
 37357
 0.2
chr5_127036963_127037114 0.38 CTC-548H10.2
37317
 0.19
chr10_128613788_128613939 0.38 ENSG00000202487
 .
 4487
 0.28
chrX_136337073_136337224 0.38 GPR101
 G protein-coupled receptor 101
 223315
 0.02
chr3_38247873_38248024 0.38 OXSR1
 oxidative stress responsive 1
 40952
 0.12
chr10_90753077_90753312 0.38 ACTA2
 actin, alpha 2, smooth muscle, aorta
 2047
 0.24
chr14_26016058_26016209 0.38 ENSG00000212270
 .
 259785
 0.02
chr13_80614475_80614626 0.38 SPRY2
 sprouty homolog 2 (Drosophila)
 299244
 0.01
chr9_89574254_89574405 0.38 GAS1
 growth arrest-specific 1
 12225
 0.31
chr1_240669972_240670123 0.38 AL646016.1
 Uncharacterized protein
 26543
 0.18
chr6_100909122_100909273 0.38 SIM1
 single-minded family bHLH transcription factor 1
 2356
 0.39
chr15_38549534_38549685 0.37 SPRED1
 sprouty-related, EVH1 domain containing 1
 4227
 0.36
chr7_105432133_105432284 0.37 ATXN7L1
 ataxin 7-like 1
 84715
 0.1
chr1_189197213_189197364 0.37 ENSG00000252553
 .
 438098
 0.01
chr5_104399872_104400023 0.37 ENSG00000252881
 .
 283857
 0.01
chr10_70096270_70096993 0.37 PBLD
 phenazine biosynthesis-like protein domain containing
 3825
 0.2
chr3_156405026_156405177 0.37 TIPARP
 TCDD-inducible poly(ADP-ribose) polymerase
 6146
 0.24
chr18_29220350_29220501 0.37 ENSG00000252379
 .
 28916
 0.13
chr8_131954085_131954236 0.37 RP11-737F9.1
6505
 0.26
chr2_216298275_216298426 0.37 FN1
 fibronectin 1
 2440
 0.3
chrY_23414698_23414849 0.37 CYorf17
 chromosome Y open reading frame 17
 133473
 0.05
chr10_6780355_6780830 0.37 PRKCQ
 protein kinase C, theta
 158329
 0.04
chr15_50151604_50151755 0.37 ATP8B4
 ATPase, class I, type 8B, member 4
 17213
 0.21
chr4_167130026_167130177 0.37 ENSG00000266254
 .
 18816
 0.28
chr5_158301830_158301981 0.37 CTD-2363C16.1
108109
 0.07
chr14_81453709_81453897 0.36 CEP128
 centrosomal protein 128kDa
 27955
 0.21
chr14_38888998_38889149 0.36 CLEC14A
 C-type lectin domain family 14, member A
 163499
 0.04
chr5_168003477_168003628 0.36 PANK3
 pantothenate kinase 3
 2803
 0.26
chr10_63402177_63402609 0.36 C10orf107
 chromosome 10 open reading frame 107
 20326
 0.24
chr4_123719562_123719754 0.36 FGF2
 fibroblast growth factor 2 (basic)
 28205
 0.16
chr10_19314438_19314589 0.36 MALRD1
 MAM and LDL receptor class A domain containing 1
 178266
 0.03
chr13_99629621_99629906 0.36 DOCK9
 dedicator of cytokinesis 9
 481
 0.85
chr14_45559377_45559745 0.35 ENSG00000212615
 .
 2115
 0.2
chr5_67577391_67577649 0.35 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 1385
 0.58
chr8_69986403_69986554 0.35 ENSG00000238808
 .
 36331
 0.24
chr6_102835538_102835689 0.35 GRIK2
 glutamate receptor, ionotropic, kainate 2
 569368
 0.0
chr6_143256936_143257087 0.35 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 9327
 0.26
chr3_33061626_33061777 0.35 CCR4
 chemokine (C-C motif) receptor 4
 68635
 0.09
chr15_80361249_80361400 0.35 ZFAND6
 zinc finger, AN1-type domain 6
 3582
 0.28
chr2_29340749_29340907 0.35 CLIP4
 CAP-GLY domain containing linker protein family, member 4
 233
 0.92
chr1_164290160_164290619 0.35 ENSG00000199849
 .
 30121
 0.25
chr16_63376236_63376387 0.35 RP11-96H17.3
275417
 0.02
chr6_13505550_13505701 0.35 GFOD1
 glucose-fructose oxidoreductase domain containing 1
 17731
 0.14
chr7_83098669_83098820 0.34 AC079799.2
114274
 0.07
chr7_136910239_136910390 0.34 hsa-mir-490
 hsa-mir-490
 43460
 0.18
chr15_35950174_35950564 0.34 DPH6
 diphthamine biosynthesis 6
 111976
 0.07
chrX_45625887_45626164 0.34 ENSG00000207725
 .
 19495
 0.22
chr14_99712277_99712758 0.34 AL109767.1
16768
 0.21
chr15_59344636_59344787 0.34 RNF111
 ring finger protein 111
 20888
 0.16
chr10_55152331_55152482 0.33 ENSG00000252161
 .
 65551
 0.15
chr18_29888572_29888839 0.33 RP11-344B2.2
21305
 0.16
chr4_117414615_117414766 0.33 MTRNR2L13
 MT-RNR2-like 13 (pseudogene)
 194674
 0.03
chr21_38831812_38831963 0.33 DYRK1A
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
 29200
 0.2
chr21_35304396_35305066 0.33 LINC00649
 long intergenic non-protein coding RNA 649
 1213
 0.41
chr4_39570973_39571124 0.33 UGDH
 UDP-glucose 6-dehydrogenase
 41117
 0.11
chr1_209558665_209558816 0.33 ENSG00000230937
 .
 46738
 0.19
chr6_125364944_125365095 0.33 RNF217
 ring finger protein 217
 4339
 0.31
chr12_118472279_118472430 0.33 RFC5
 replication factor C (activator 1) 5, 36.5kDa
 17820
 0.18
chr5_172286846_172286997 0.33 ERGIC1
 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
 25507
 0.16
chr1_243687933_243688084 0.33 RP11-269F20.1
20826
 0.27
chr8_41277096_41277247 0.33 ENSG00000238936
 .
 7003
 0.23
chrX_31453419_31453570 0.33 ENSG00000252903
 .
 87185
 0.1
chr1_182991327_182991478 0.33 LAMC1
 laminin, gamma 1 (formerly LAMB2)
 1193
 0.49
chr5_110560941_110561277 0.33 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 1325
 0.51
chr2_106372613_106372764 0.33 NCK2
 NCK adaptor protein 2
 10500
 0.29
chr1_38510289_38510696 0.32 POU3F1
 POU class 3 homeobox 1
 1958
 0.27
chr2_230148069_230148220 0.32 PID1
 phosphotyrosine interaction domain containing 1
 12143
 0.27
chr4_110217881_110218141 0.32 COL25A1
 collagen, type XXV, alpha 1
 5512
 0.3
chr7_157225535_157225734 0.32 AC006372.6
80354
 0.09
chr12_41084046_41084197 0.32 CNTN1
 contactin 1
 2123
 0.46
chr4_68593746_68593897 0.32 UBA6-AS1
 UBA6 antisense RNA 1 (head to head)
 4041
 0.2
chr5_30785800_30785951 0.32 CDH6
 cadherin 6, type 2, K-cadherin (fetal kidney)
 407982
 0.01
chr10_60580536_60580825 0.32 BICC1
 bicaudal C homolog 1 (Drosophila)
 27385
 0.23
chr12_111003570_111003721 0.32 PPTC7
 PTC7 protein phosphatase homolog (S. cerevisiae)
 17480
 0.14
chr14_38613607_38613758 0.32 CTD-2058B24.2
49804
 0.14
chr2_201248196_201249000 0.32 ENSG00000264798
 .
 3300
 0.23
chr6_37483764_37484117 0.32 CCDC167
 coiled-coil domain containing 167
 16242
 0.19
chr10_75912778_75912929 0.32 ADK
 adenosine kinase
 1866
 0.31
chr2_213962198_213962349 0.32 IKZF2
 IKAROS family zinc finger 2 (Helios)
 51080
 0.16
chr1_8741272_8741496 0.32 RERE
 arginine-glutamic acid dipeptide (RE) repeats
 21894
 0.23
chr2_29850591_29850818 0.31 ENSG00000242699
 .
 53485
 0.16
chr3_79625949_79626100 0.31 ENSG00000216116
 .
 7810
 0.3
chr4_151600832_151601026 0.31 ENSG00000221235
 .
 39911
 0.19
chr18_20558047_20558453 0.31 RBBP8
 retinoblastoma binding protein 8
 9445
 0.15
chr18_70644965_70645116 0.31 NETO1
 neuropilin (NRP) and tolloid (TLL)-like 1
 109856
 0.07
chr12_113797502_113797653 0.31 SLC8B1
 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
 279
 0.85
chr1_192547268_192547419 0.31 RGS1
 regulator of G-protein signaling 1
 2440
 0.31
chr6_14127798_14127949 0.31 CD83
 CD83 molecule
 10001
 0.25
chr5_125703700_125704120 0.31 GRAMD3
 GRAM domain containing 3
 3095
 0.37
chr2_32940890_32941041 0.31 TTC27
 tetratricopeptide repeat domain 27
 37020
 0.2
chr21_35266767_35266918 0.31 ATP5O
 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
 14557
 0.14
chr2_97593731_97594362 0.31 ENSG00000252845
 .
 28506
 0.12
chr2_110376280_110376431 0.31 SOWAHC
 sosondowah ankyrin repeat domain family member C
 4444
 0.21
chr1_25060751_25060902 0.31 CLIC4
 chloride intracellular channel 4
 11022
 0.2
chr6_12280277_12280428 0.31 EDN1
 endothelin 1
 10244
 0.3
chr20_53950807_53950958 0.31 ENSG00000252089
 .
 474531
 0.01
chr9_33446798_33447442 0.31 AQP3
 aquaporin 3 (Gill blood group)
 489
 0.76
chr1_76788853_76789004 0.31 ST6GALNAC3
 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
 248524
 0.02
chr3_121373349_121373500 0.31 ENSG00000243544
 .
 281
 0.82
chr18_13275881_13276032 0.31 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 2146
 0.32
chr4_110223153_110224430 0.31 COL25A1
 collagen, type XXV, alpha 1
 8
 0.99
chr12_61131831_61131982 0.31 ENSG00000251822
 .
 374303
 0.01
chr7_79063706_79063857 0.31 ENSG00000234456
 .
 18417
 0.22
chr2_40049399_40049550 0.31 SLC8A1-AS1
 SLC8A1 antisense RNA 1
 35881
 0.19
chrX_131763564_131763715 0.31 HS6ST2-AS1
 HS6ST2 antisense RNA 1
 38031
 0.17
chr6_106549276_106549427 0.30 RP1-134E15.3
1336
 0.46
chr3_24225373_24225524 0.30 THRB
 thyroid hormone receptor, beta
 18362
 0.28
chr5_165288349_165288500 0.30 ENSG00000252794
 .
 251978
 0.02
chr15_24112084_24112235 0.30 ENSG00000206616
 .
 89469
 0.09
chr22_46462327_46462478 0.30 RP6-109B7.4
3369
 0.13
chr16_75836248_75836399 0.30 ENSG00000199299
 .
 58732
 0.12
chr1_154358065_154358416 0.30 IL6R
 interleukin 6 receptor
 19429
 0.11
chr4_75224942_75225093 0.30 EREG
 epiregulin
 5843
 0.21
chr13_79182716_79183828 0.30 POU4F1
 POU class 4 homeobox 1
 5599
 0.19
chr7_25902294_25902669 0.30 ENSG00000199085
 .
 87125
 0.1
chr4_20261154_20261305 0.30 SLIT2
 slit homolog 2 (Drosophila)
 4686
 0.35
chr13_82572321_82572472 0.29 ENSG00000222486
 .
 732514
 0.0
chr16_4146823_4146974 0.29 ADCY9
 adenylate cyclase 9
 17129
 0.21
chr8_67524217_67524427 0.29 MYBL1
 v-myb avian myeloblastosis viral oncogene homolog-like 1
 820
 0.61
chr7_54625683_54625834 0.29 GS1-18A18.1
1095
 0.57
chr12_126874132_126874719 0.29 TMEM132B
 transmembrane protein 132B
 767383
 0.0
chr5_100224849_100225000 0.29 ST8SIA4
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
 13994
 0.28
chr15_50977663_50977814 0.29 TRPM7
 transient receptor potential cation channel, subfamily M, member 7
 1230
 0.45
chr3_107850710_107850861 0.29 CD47
 CD47 molecule
 40913
 0.19
chrX_141646229_141646380 0.29 ENSG00000266319
 .
 48427
 0.19
chr9_12772195_12772422 0.29 LURAP1L
 leucine rich adaptor protein 1-like
 2712
 0.28
chr5_66445517_66445857 0.29 MAST4
 microtubule associated serine/threonine kinase family member 4
 7425
 0.28
chr6_66722316_66722467 0.29 EYS
 eyes shut homolog (Drosophila)
 305273
 0.01
chr10_60495190_60495341 0.29 BICC1
 bicaudal C homolog 1 (Drosophila)
 58030
 0.16
chr12_78337025_78337244 0.29 NAV3
 neuron navigator 3
 22922
 0.28
chr2_120041983_120042165 0.29 STEAP3-AS1
 STEAP3 antisense RNA 1
 35427
 0.15
chr7_28133742_28133893 0.29 JAZF1
 JAZF zinc finger 1
 22514
 0.2
chr12_55266839_55266990 0.29 MUCL1
 mucin-like 1
 18593
 0.23
chr4_140808579_140808865 0.29 MAML3
 mastermind-like 3 (Drosophila)
 2484
 0.4
chr9_123956593_123956744 0.29 RAB14
 RAB14, member RAS oncogene family
 7479
 0.16

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of POU3F3_POU3F4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 0.4 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.1 0.4 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.1 0.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.3 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.1 GO:0060594 mammary gland specification(GO:0060594)
0.1 0.2 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.1 0.2 GO:0010613 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.1 0.2 GO:0070295 renal water absorption(GO:0070295)
0.1 0.2 GO:0009822 alkaloid catabolic process(GO:0009822)
0.1 0.1 GO:0019049 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.2 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 0.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 0.1 GO:0060197 cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.1 0.3 GO:0033084 regulation of immature T cell proliferation in thymus(GO:0033084)
0.1 0.3 GO:0010667 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1 0.3 GO:0042023 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.1 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 0.3 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.1 0.1 GO:0032674 interleukin-5 production(GO:0032634) regulation of interleukin-5 production(GO:0032674)
0.1 0.2 GO:0031223 auditory behavior(GO:0031223)
0.1 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 0.2 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1 0.3 GO:0034331 cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.1 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.6 GO:0014037 Schwann cell differentiation(GO:0014037)
0.0 0.1 GO:0014889 muscle atrophy(GO:0014889)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0070254 mucus secretion(GO:0070254)
0.0 0.1 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.2 GO:0090218 positive regulation of lipid kinase activity(GO:0090218)
0.0 0.2 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0010159 specification of organ position(GO:0010159)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.1 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.0 GO:0001705 ectoderm formation(GO:0001705)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.2 GO:0055091 phospholipid homeostasis(GO:0055091)
0.0 0.0 GO:0060463 lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0 0.3 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.1 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0006925 inflammatory cell apoptotic process(GO:0006925)
0.0 0.1 GO:1904251 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0 0.1 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0 0.0 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:0003181 atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0 0.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.4 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.0 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.0 GO:0048520 positive regulation of behavior(GO:0048520)
0.0 0.1 GO:0006273 lagging strand elongation(GO:0006273)
0.0 0.3 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.4 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.0 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.0 0.1 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0045007 depurination(GO:0045007)
0.0 0.0 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0003214 cardiac left ventricle morphogenesis(GO:0003214)
0.0 0.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.0 GO:0002887 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.0 GO:0033025 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0 0.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.0 0.1 GO:0021873 forebrain neuroblast division(GO:0021873)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0055057 neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0 0.1 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.1 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.0 GO:0051284 negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.1 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.0 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.0 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.0 0.1 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.1 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.0 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.0 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.0 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.1 GO:0031000 response to caffeine(GO:0031000)
0.0 0.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.0 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.0 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0032288 myelin assembly(GO:0032288)
0.0 0.1 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0046337 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.0 GO:0061117 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0 0.1 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.0 GO:0001743 optic placode formation(GO:0001743)
0.0 0.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.0 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0 0.1 GO:0071800 podosome assembly(GO:0071800)
0.0 0.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:0006949 syncytium formation(GO:0006949)
0.0 0.2 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0 0.1 GO:0048841 regulation of axon extension involved in axon guidance(GO:0048841)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0051963 regulation of synapse assembly(GO:0051963)
0.0 0.0 GO:0070977 organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0055075 potassium ion homeostasis(GO:0055075)
0.0 0.0 GO:0002911 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.0 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.0 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.0 0.0 GO:0061213 positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.0 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.0 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.1 GO:0060347 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.0 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.2 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.4 GO:0007602 phototransduction(GO:0007602)
0.0 0.1 GO:0009103 lipopolysaccharide biosynthetic process(GO:0009103)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.0 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.2 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309)
0.0 0.0 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.0 GO:0060535 trachea morphogenesis(GO:0060439) trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0 0.1 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.0 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0021546 rhombomere development(GO:0021546)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.0 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.0 GO:0036315 cellular response to sterol(GO:0036315) cellular response to cholesterol(GO:0071397)
0.0 0.0 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0032119 sequestering of zinc ion(GO:0032119)
0.0 0.0 GO:0060457 negative regulation of digestive system process(GO:0060457)
0.0 0.0 GO:0090266 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.2 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.1 GO:0043113 receptor clustering(GO:0043113)
0.0 0.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.0 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.0 GO:0032730 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0 0.0 GO:0032825 regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.0 GO:0034244 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.0 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.0 GO:0019532 oxalate transport(GO:0019532)
0.0 0.4 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0030325 adrenal gland development(GO:0030325)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.2 GO:0043259 laminin-10 complex(GO:0043259)
0.1 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.3 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0031045 dense core granule(GO:0031045)
0.0 0.2 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0032156 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.1 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0043205 fibril(GO:0043205)
0.0 0.1 GO:0043256 laminin complex(GO:0043256)
0.0 0.1 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0000299 obsolete integral to membrane of membrane fraction(GO:0000299)
0.0 0.0 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0031010 ISWI-type complex(GO:0031010)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.2 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.2 GO:0031705 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.1 0.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.2 GO:0005113 patched binding(GO:0005113)
0.1 0.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.5 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.4 GO:0016595 glutamate binding(GO:0016595)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.2 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.2 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.2 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.1 GO:0031782 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.3 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.0 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.2 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.0 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.0 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.0 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.1 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.0 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.2 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.0 GO:0019863 IgE binding(GO:0019863)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.0 GO:0034618 arginine binding(GO:0034618)
0.0 0.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.0 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.0 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.0 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.0 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.2 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.1 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.0 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME SIGNALLING BY NGF Genes involved in Signalling by NGF
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.1 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.0 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.0 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.1 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.0 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.1 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.1 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus