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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for POU4F1_POU4F3

Z-value: 1.20

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Transcription factors associated with POU4F1_POU4F3

Gene Symbol	Gene ID	Gene Info
POU4F1 Ensembl NCBI GeneCards UniProt	ENSG00000152192.6	POU4F1
POU4F3 Ensembl NCBI GeneCards UniProt	ENSG00000091010.4	POU4F3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
POU4F1	chr13_79182716_79183828	5599	0.193498	0.55	1.2e-01	Click!
POU4F1	chr13_79181751_79181902	4153	0.209565	0.53	1.4e-01	Click!
POU4F1	chr13_79182558_79182709	4960	0.199043	0.47	2.0e-01	Click!
POU4F1	chr13_79181975_79182128	4378	0.206092	0.45	2.2e-01	Click!
POU4F1	chr13_79176958_79177133	628	0.709557	-0.32	3.9e-01	Click!
POU4F3	chr5_145719881_145720125	1416	0.467441	0.79	1.1e-02	Click!
POU4F3	chr5_145724296_145724632	5877	0.231468	0.60	9.0e-02	Click!
POU4F3	chr5_145725536_145725687	7024	0.223641	0.38	3.2e-01	Click!
POU4F3	chr5_145725300_145725451	6788	0.225019	-0.08	8.4e-01	Click!

Activity of the POU4F1_POU4F3 motif across conditions

Conditions sorted by the z-value of the POU4F1_POU4F3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_116833589_116833880	1.15	TRAPPC3L	trafficking protein particle complex 3-like	228	0.83
chr12_91574306_91575101	0.70	DCN	decorin	50	0.99
chr7_18549761_18549974	0.65	HDAC9	histone deacetylase 9	931	0.71
chr9_22008020_22008450	0.62	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	717	0.61
chr17_46646430_46646725	0.62	HOXB3	homeobox B3	4808	0.08
chr18_811181_811332	0.61	YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	983	0.49
chr11_111849006_111849202	0.60	DIXDC1	DIX domain containing 1	1071	0.39
chr4_108746841_108747185	0.57	SGMS2	sphingomyelin synthase 2	649	0.76
chr2_18481003_18481326	0.56	ENSG00000212455	.	259165	0.02
chr1_162603392_162603656	0.55	DDR2	discoidin domain receptor tyrosine kinase 2	1264	0.48
chr2_36581700_36582677	0.53	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	881	0.74
chr6_100717098_100717249	0.51	RP1-121G13.2		157821	0.04
chr11_86085513_86085741	0.51	CCDC81	coiled-coil domain containing 81	151	0.96
chr9_89952337_89952906	0.51	ENSG00000212421	.	77256	0.11
chr1_88928130_88928341	0.50	ENSG00000239504	.	15562	0.29
chr11_68036812_68036963	0.50	C11orf24	chromosome 11 open reading frame 24	2528	0.3
chr10_49812568_49813319	0.48	ARHGAP22	Rho GTPase activating protein 22	54	0.98
chr6_47446841_47447070	0.48	CD2AP	CD2-associated protein	1430	0.42
chr12_52258184_52258357	0.48	ANKRD33	ankyrin repeat domain 33	23474	0.16
chr22_47241536_47241796	0.48	ENSG00000221672	.	2137	0.4
chr15_48010788_48011252	0.48	SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	334	0.93
chr15_63050120_63050513	0.47	TLN2	talin 2	473	0.82
chr9_97812256_97812766	0.47	ENSG00000207563	.	34979	0.12
chr13_80912266_80912417	0.46	SPRY2	sprouty homolog 2 (Drosophila)	1453	0.53
chr18_7572735_7572928	0.46	PTPRM	protein tyrosine phosphatase, receptor type, M	5014	0.33
chr7_82070146_82070432	0.46	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	2742	0.43
chr12_115119923_115120074	0.46	TBX3	T-box 3	1397	0.48
chr16_27590300_27590451	0.46	KIAA0556	KIAA0556	5147	0.22
chr5_141701461_141701673	0.46	SPRY4	sprouty homolog 4 (Drosophila)	2180	0.34
chr13_76213551_76213793	0.45	LMO7	LIM domain 7	3213	0.22
chr6_152701966_152702349	0.45	SYNE1-AS1	SYNE1 antisense RNA 1	476	0.79
chr3_114477857_114478359	0.44	ZBTB20	zinc finger and BTB domain containing 20	10	0.99
chr2_200446759_200446999	0.44	SATB2	SATB homeobox 2	110890	0.07
chr3_79815928_79816150	0.43	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	926	0.74
chr6_151597751_151597996	0.43	ENSG00000252431	.	3874	0.18
chr7_123389891_123390042	0.42	RP11-390E23.6		844	0.4
chr5_102202312_102202463	0.41	PAM	peptidylglycine alpha-amidating monooxygenase	567	0.87
chr12_71054468_71054762	0.41	PTPRB	protein tyrosine phosphatase, receptor type, B	23395	0.24
chr1_95389567_95389941	0.41	CNN3	calponin 3, acidic	1583	0.36
chr8_97468793_97469144	0.40	ENSG00000202095	.	25580	0.2
chr4_183413334_183413747	0.40	TENM3	teneurin transmembrane protein 3	43388	0.17
chr19_55678355_55678541	0.39	ENSG00000239137	.	91	0.81
chr6_72178134_72178480	0.39	ENSG00000207827	.	64983	0.11
chr4_157891142_157892336	0.38	PDGFC	platelet derived growth factor C	316	0.91
chr1_200148726_200148877	0.37	ENSG00000221403	.	34839	0.21
chr3_13080776_13080942	0.36	IQSEC1	IQ motif and Sec7 domain 1	33758	0.22
chr3_117454157_117454380	0.36	ENSG00000206889	.	191216	0.03
chrX_138909289_138909440	0.36	ATP11C	ATPase, class VI, type 11C	5083	0.25
chr2_26624476_26625174	0.36	DRC1	dynein regulatory complex subunit 1 homolog (Chlamydomonas)	41	0.98
chr7_12811096_12811403	0.36	ENSG00000199470	.	70735	0.11
chr17_8532417_8532568	0.36	MYH10	myosin, heavy chain 10, non-muscle	1543	0.44
chr1_61692922_61693140	0.36	RP4-802A10.1		102626	0.08
chr4_114897314_114897610	0.36	ARSJ	arylsulfatase family, member J	2690	0.37
chr1_196620715_196621368	0.35	CFH	complement factor H	33	0.98
chr2_242257443_242257594	0.35	HDLBP	high density lipoprotein binding protein	1042	0.41
chr9_84947315_84947575	0.35	SPATA31D1	SPATA31 subfamily D, member 1	343758	0.01
chrY_14922193_14922344	0.35	USP9Y	ubiquitin specific peptidase 9, Y-linked	36702	0.22
chr12_91572375_91572546	0.35	DCN	decorin	131	0.98
chr1_116089167_116089325	0.35	ENSG00000239984	.	59846	0.11
chr1_66737250_66737924	0.35	PDE4B	phosphodiesterase 4B, cAMP-specific	14257	0.29
chr6_169653692_169653887	0.35	THBS2	thrombospondin 2	350	0.92
chr11_100587578_100587729	0.35	CTD-2383M3.1		28967	0.17
chr6_127840298_127840479	0.34	SOGA3	SOGA family member 3	52	0.98
chr2_218193929_218194080	0.34	ENSG00000251982	.	77725	0.11
chr8_42072731_42073079	0.34	PLAT	plasminogen activator, tissue	7663	0.16
chr6_152002769_152002982	0.34	ESR1	estrogen receptor 1	8756	0.26
chr2_145787262_145787615	0.34	ENSG00000253036	.	305200	0.01
chr8_18870397_18870669	0.34	PSD3	pleckstrin and Sec7 domain containing 3	663	0.74
chr13_74862980_74863131	0.34	ENSG00000206617	.	296	0.95
chr15_57512191_57512484	0.34	TCF12	transcription factor 12	673	0.79
chr15_99788624_99789059	0.34	TTC23	tetratricopeptide repeat domain 23	895	0.51
chr6_140373176_140373387	0.33	ENSG00000252107	.	106550	0.08
chr11_9587935_9588242	0.33	WEE1	WEE1 G2 checkpoint kinase	7140	0.16
chr2_202987834_202988283	0.33	AC079354.3		6277	0.17
chr8_25317575_25317860	0.33	CDCA2	cell division cycle associated 2	1002	0.5
chr2_226896266_226896823	0.33	NYAP2	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	622947	0.0
chr10_63779003_63779237	0.33	ARID5B	AT rich interactive domain 5B (MRF1-like)	29850	0.22
chr7_66055880_66056152	0.33	KCTD7	potassium channel tetramerization domain containing 7	37852	0.16
chr19_39186934_39187210	0.32	CTB-186G2.4		2826	0.16
chr2_9348603_9349207	0.32	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	2011	0.46
chr15_52123506_52123657	0.32	TMOD3	tropomodulin 3 (ubiquitous)	1754	0.32
chr2_62934247_62934470	0.32	EHBP1	EH domain binding protein 1	31	0.98
chr9_96932049_96932529	0.32	ENSG00000199165	.	5945	0.16
chr18_9109419_9109570	0.32	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	5414	0.17
chr1_78471558_78472034	0.32	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	1258	0.34
chr2_33516384_33516581	0.32	LTBP1	latent transforming growth factor beta binding protein 1	233	0.94
chr18_53144293_53144444	0.31	ENSG00000264571	.	2084	0.31
chr15_37175433_37176047	0.31	ENSG00000212511	.	30899	0.23
chr21_18376217_18376955	0.31	ENSG00000239023	.	285269	0.01
chr6_109414275_109414426	0.31	SESN1	sestrin 1	1672	0.32
chr13_33476928_33477100	0.31	KL	klotho	113193	0.06
chr8_49831590_49831741	0.31	SNAI2	snail family zinc finger 2	2323	0.45
chr5_10596142_10596297	0.31	ANKRD33B	ankyrin repeat domain 33B	31639	0.16
chr1_8298719_8298899	0.30	ENSG00000200975	.	32152	0.15
chr17_79317268_79317735	0.30	TMEM105	transmembrane protein 105	13027	0.13
chr18_53253489_53253863	0.30	TCF4	transcription factor 4	326	0.93
chr15_70819174_70819403	0.30	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	175332	0.03
chr2_46928125_46928276	0.30	SOCS5	suppressor of cytokine signaling 5	1874	0.38
chr2_219471971_219472122	0.30	PLCD4	phospholipase C, delta 4	442	0.69
chr6_52925441_52925592	0.30	ICK	intestinal cell (MAK-like) kinase	1052	0.42
chr3_185462581_185462876	0.29	ENSG00000265470	.	22964	0.19
chr2_216298275_216298426	0.29	FN1	fibronectin 1	2440	0.3
chrX_17395799_17395950	0.29	NHS	Nance-Horan syndrome (congenital cataracts and dental anomalies)	2331	0.33
chr5_33794654_33794915	0.29	ENSG00000201623	.	93483	0.08
chr3_60921693_60921844	0.29	ENSG00000212211	.	79491	0.12
chr12_60131988_60132146	0.29	SLC16A7	solute carrier family 16 (monocarboxylate transporter), member 7	30773	0.24
chr7_151328064_151328292	0.29	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	1261	0.55
chr9_126270533_126270733	0.28	RP11-230L22.4		16470	0.24
chr3_191217380_191217807	0.28	PYDC2	pyrin domain containing 2	38641	0.2
chr4_77703399_77704071	0.28	RP11-359D14.3		19382	0.18
chr4_53966969_53967196	0.28	RP11-752D24.2		155226	0.04
chr3_189735394_189735583	0.28	ENSG00000265045	.	96235	0.07
chr15_77710162_77710461	0.28	PEAK1	pseudopodium-enriched atypical kinase 1	2131	0.32
chr1_64240383_64241287	0.28	ROR1	receptor tyrosine kinase-like orphan receptor 1	1121	0.63
chr7_28726429_28726958	0.28	CREB5	cAMP responsive element binding protein 5	1095	0.68
chr5_60598656_60599005	0.27	ZSWIM6	zinc finger, SWIM-type containing 6	29270	0.23
chr2_170591300_170591489	0.27	KLHL23	kelch-like family member 23	668	0.64
chr8_119086940_119087091	0.27	EXT1	exostosin glycosyltransferase 1	35638	0.24
chr1_215447400_215447702	0.27	KCNK2	potassium channel, subfamily K, member 2	190691	0.03
chr2_219435817_219435968	0.27	RQCD1	RCD1 required for cell differentiation1 homolog (S. pombe)	2294	0.17
chr11_46934289_46934467	0.27	LRP4	low density lipoprotein receptor-related protein 4	5795	0.19
chr16_24697486_24697909	0.27	TNRC6A	trinucleotide repeat containing 6A	43319	0.18
chr5_52707192_52707393	0.27	FST	follistatin	68947	0.13
chr8_11382556_11382707	0.27	RP11-148O21.3		29085	0.11
chr1_65730855_65731313	0.27	DNAJC6	DnaJ (Hsp40) homolog, subfamily C, member 6	647	0.77
chr17_57230413_57230606	0.27	SKA2	spindle and kinetochore associated complex subunit 2	1347	0.23
chr6_75913619_75913933	0.27	COL12A1	collagen, type XII, alpha 1	1268	0.52
chr17_38708496_38708766	0.27	CCR7	chemokine (C-C motif) receptor 7	8634	0.17
chr2_177418868_177419346	0.26	ENSG00000252027	.	110297	0.06
chr9_75169048_75169276	0.26	ENSG00000238402	.	27010	0.21
chr15_90543166_90543622	0.26	ZNF710	zinc finger protein 710	1230	0.4
chr17_3572880_3573031	0.26	EMC6	ER membrane protein complex subunit 6	839	0.33
chr3_9443823_9444009	0.26	SETD5-AS1	SETD5 antisense RNA 1	3653	0.18
chr17_7156412_7156575	0.26	ELP5	elongator acetyltransferase complex subunit 5	551	0.36
chr9_16704056_16704545	0.26	BNC2	basonuclin 2	780	0.71
chr20_17947911_17948977	0.26	SNX5	sorting nexin 5	657	0.53
chr2_24676770_24677172	0.26	NCOA1	nuclear receptor coactivator 1	37830	0.18
chr1_68149789_68149968	0.26	GADD45A	growth arrest and DNA-damage-inducible, alpha	866	0.65
chr11_18368890_18369041	0.26	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa	314	0.84
chr4_170147421_170147572	0.26	RP11-327O17.2		24551	0.22
chr6_113012091_113012242	0.26	ENSG00000252215	.	158782	0.04
chr8_38242197_38242597	0.25	LETM2	leucine zipper-EF-hand containing transmembrane protein 2	1328	0.3
chr10_76716977_76717128	0.25	RP11-77G23.5		66957	0.1
chr18_20558047_20558453	0.25	RBBP8	retinoblastoma binding protein 8	9445	0.15
chr1_17766506_17766801	0.25	RCC2	regulator of chromosome condensation 2	433	0.8
chr13_66190370_66190521	0.25	ENSG00000221685	.	247860	0.02
chr1_245329429_245329885	0.25	KIF26B	kinesin family member 26B	11370	0.2
chr2_50371104_50371319	0.25	NRXN1	neurexin 1	124800	0.06
chr8_15398472_15398721	0.25	TUSC3	tumor suppressor candidate 3	804	0.72
chr10_119122644_119122795	0.25	ENSG00000222197	.	4852	0.24
chr8_119120675_119121215	0.25	EXT1	exostosin glycosyltransferase 1	1708	0.54
chr17_14028855_14029146	0.25	ENSG00000252305	.	51448	0.12
chr8_118981794_118981945	0.25	EXT1	exostosin glycosyltransferase 1	140784	0.05
chr3_150130220_150130998	0.25	TSC22D2	TSC22 domain family, member 2	1813	0.47
chr15_38547811_38548278	0.25	SPRED1	sprouty-related, EVH1 domain containing 1	2662	0.42
chr20_45114435_45114586	0.25	ZNF334	zinc finger protein 334	20499	0.19
chr11_102039159_102039310	0.25	YAP1	Yes-associated protein 1	17578	0.19
chr10_117930701_117930852	0.24	GFRA1	GDNF family receptor alpha 1	84531	0.1
chr21_17792662_17793003	0.24	ENSG00000207638	.	118577	0.06
chr22_40673331_40673671	0.24	TNRC6B	trinucleotide repeat containing 6B	12494	0.23
chr6_75316769_75316920	0.24	ENSG00000264884	.	112715	0.07
chr18_20139314_20139465	0.24	ENSG00000206827	.	88156	0.09
chr14_100260565_100260825	0.24	EML1	echinoderm microtubule associated protein like 1	923	0.67
chr7_66120646_66120797	0.24	RP4-756H11.3		1148	0.52
chr3_25193430_25193657	0.24	RARB	retinoic acid receptor, beta	22280	0.26
chr4_74316638_74316988	0.24	AFP	alpha-fetoprotein	14849	0.2
chr8_124281132_124281572	0.24	ZHX1-C8ORF76	ZHX1-C8ORF76 readthrough	1725	0.21
chr6_49294723_49295128	0.24	ENSG00000252457	.	17596	0.27
chr20_18446613_18446764	0.24	DZANK1	double zinc ribbon and ankyrin repeat domains 1	663	0.48
chr6_27060216_27060434	0.24	ENSG00000222800	.	17434	0.13
chr5_54456050_54456451	0.24	GPX8	glutathione peroxidase 8 (putative)	252	0.86
chr18_60905231_60905454	0.24	ENSG00000238988	.	43444	0.14
chr11_82570104_82570255	0.24	PRCP	prolylcarboxypeptidase (angiotensinase C)	366	0.88
chr6_45448601_45449137	0.24	RUNX2	runt-related transcription factor 2	58647	0.13
chr7_44801800_44801951	0.24	ZMIZ2	zinc finger, MIZ-type containing 2	6071	0.17
chr2_151091538_151091758	0.24	RND3	Rho family GTPase 3	250248	0.02
chr17_46240634_46240785	0.24	ENSG00000221739	.	6836	0.12
chr7_80547175_80548098	0.24	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	863	0.76
chr2_67620410_67620561	0.24	ETAA1	Ewing tumor-associated antigen 1	3966	0.38
chr5_140940128_140940366	0.24	CTD-2024I7.13		2369	0.19
chr9_81217104_81217255	0.23	PSAT1	phosphoserine aminotransferase 1	305120	0.01
chr14_31464257_31464552	0.23	ENSG00000207952	.	19544	0.17
chr1_178836761_178836994	0.23	ANGPTL1	angiopoietin-like 1	1536	0.43
chr10_79397825_79398297	0.23	KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	66	0.98
chr12_109195839_109196070	0.23	ENSG00000264043	.	23907	0.13
chr10_89917929_89918366	0.23	ENSG00000200891	.	163695	0.04
chr18_55889348_55889572	0.23	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	657	0.77
chr15_88020923_88021173	0.23	ENSG00000207150	.	3528	0.4
chr14_95963717_95963868	0.23	RP11-1070N10.3	Uncharacterized protein	18681	0.14
chr11_89113858_89114276	0.23	NOX4	NADPH oxidase 4	109833	0.07
chr1_110693882_110694033	0.23	SLC6A17	solute carrier family 6 (neutral amino acid transporter), member 17	849	0.49
chr2_110366652_110366826	0.23	AC011753.5		3464	0.22
chr2_70518346_70518567	0.23	SNRPG	small nuclear ribonucleoprotein polypeptide G	1452	0.31
chr9_694286_694821	0.23	RP11-130C19.3		8998	0.22
chr3_106059964_106060303	0.23	ENSG00000200610	.	174611	0.04
chr21_34918443_34918594	0.23	GART	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	2721	0.18
chr11_108777750_108777901	0.23	ENSG00000201243	.	98419	0.08
chr17_35851874_35852313	0.23	DUSP14	dual specificity phosphatase 14	523	0.79
chr8_62621050_62621416	0.23	ASPH	aspartate beta-hydroxylase	5851	0.24
chr20_33907930_33908081	0.22	FAM83C	family with sequence similarity 83, member C	27801	0.09

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F1_POU4F3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.3	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2	0.5	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.1	0.4	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.5	GO:0060437	lung growth(GO:0060437)
0.1	0.4	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.1	0.3	GO:0071692	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.1	0.3	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.1	0.5	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.1	0.4	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.1	0.2	GO:0060596	mammary placode formation(GO:0060596)
0.1	0.2	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.1	0.2	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.1	0.2	GO:0010842	retina layer formation(GO:0010842)
0.1	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.1	GO:0045636	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.1	0.2	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.1	0.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.1	0.2	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.2	GO:0031394	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.2	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.4	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.5	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.2	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.2	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.2	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0060751	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.0	0.3	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.4	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.0	0.1	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0032641	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0032328	alanine transport(GO:0032328)
0.0	0.1	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0090195	chemokine secretion(GO:0090195) regulation of chemokine secretion(GO:0090196) positive regulation of chemokine secretion(GO:0090197)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0006188	IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.1	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.1	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.1	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.0	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.3	GO:0031000	response to caffeine(GO:0031000)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0045628	regulation of T-helper 2 cell differentiation(GO:0045628)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0007341	penetration of zona pellucida(GO:0007341)
0.0	0.1	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	0.3	GO:0043114	regulation of vascular permeability(GO:0043114)
0.0	0.1	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.2	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0072124	glomerular mesangial cell proliferation(GO:0072110) regulation of glomerular mesangial cell proliferation(GO:0072124)
0.0	0.2	GO:0006907	pinocytosis(GO:0006907)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.0	GO:1902337	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) regulation of apoptotic process involved in morphogenesis(GO:1902337) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747) regulation of apoptotic process involved in development(GO:1904748)
0.0	0.3	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.3	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	0.0	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.0	GO:0060998	regulation of dendritic spine development(GO:0060998)
0.0	0.0	GO:0044557	relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0	0.2	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.2	GO:0007616	long-term memory(GO:0007616)
0.0	0.1	GO:0032376	positive regulation of sterol transport(GO:0032373) positive regulation of cholesterol transport(GO:0032376)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0031033	myosin filament organization(GO:0031033)
0.0	0.3	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.5	GO:0048009	insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0	0.2	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.1	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.5	GO:0048010	vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0014056	acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.0	0.1	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.3	GO:0007340	acrosome reaction(GO:0007340)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.0	GO:0030146	obsolete diuresis(GO:0030146)
0.0	0.1	GO:0010560	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.4	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.3	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.2	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:2000144	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.1	GO:0048935	peripheral nervous system neuron development(GO:0048935)
0.0	0.0	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.0	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002)
0.0	0.1	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.1	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0032288	myelin assembly(GO:0032288)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.2	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.0	GO:0090036	regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.2	GO:0060079	excitatory postsynaptic potential(GO:0060079)
0.0	0.0	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.0	0.0	GO:0060298	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742) positive regulation of sarcomere organization(GO:0060298)
0.0	0.0	GO:0051014	actin filament severing(GO:0051014)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.0	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.2	GO:0050999	regulation of nitric-oxide synthase activity(GO:0050999)
0.0	0.0	GO:0051140	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.0	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.0	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.2	GO:0030520	intracellular estrogen receptor signaling pathway(GO:0030520)
0.0	0.1	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.0	0.5	GO:0007043	cell-cell junction assembly(GO:0007043)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.0	GO:0001696	gastric acid secretion(GO:0001696)
0.0	0.0	GO:0003148	outflow tract septum morphogenesis(GO:0003148)
0.0	0.0	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:1901983	regulation of histone acetylation(GO:0035065) regulation of protein acetylation(GO:1901983) regulation of peptidyl-lysine acetylation(GO:2000756)
0.0	0.1	GO:0042249	establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.0	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.3	GO:0007098	centrosome cycle(GO:0007098)
0.0	0.0	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.0	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.0	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.0	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.0	GO:0050686	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0001893	maternal placenta development(GO:0001893)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.2	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.4	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.3	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.2	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.2	GO:0032449	CBM complex(GO:0032449)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.3	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.4	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0098878	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.2	GO:0031941	filamentous actin(GO:0031941)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.5	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.3	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.2	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.0	GO:0044291	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.4	GO:0034704	calcium channel complex(GO:0034704)
0.0	0.1	GO:0043034	costamere(GO:0043034)
0.0	0.0	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.0	GO:0032432	actin filament bundle(GO:0032432)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.9	GO:0060076	excitatory synapse(GO:0060076)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0043205	fibril(GO:0043205)
0.0	0.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.1	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.0	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.8	GO:0001726	ruffle(GO:0001726)
0.0	0.9	GO:0034705	potassium channel complex(GO:0034705)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.2	0.7	GO:0030215	semaphorin receptor binding(GO:0030215)
0.2	0.5	GO:0016842	amidine-lyase activity(GO:0016842)
0.1	0.5	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.3	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.3	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	0.3	GO:0030172	troponin C binding(GO:0030172)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.1	GO:0070052	collagen V binding(GO:0070052)
0.1	0.4	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.1	0.2	GO:0034056	estrogen response element binding(GO:0034056)
0.1	0.3	GO:0008046	axon guidance receptor activity(GO:0008046)
0.1	0.4	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	1.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	0.2	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.3	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.2	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.4	GO:0046970	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.2	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.4	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.2	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.2	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.4	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.2	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.4	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.1	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.4	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.3	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.2	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.2	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0016595	glutamate binding(GO:0016595)
0.0	0.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.4	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.0	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.2	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.1	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	0.2	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.4	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.2	GO:0045296	cadherin binding(GO:0045296)
0.0	0.1	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0048185	activin binding(GO:0048185)
0.0	0.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.0	GO:0031544	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0034416	bisphosphoglycerate phosphatase activity(GO:0034416)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.2	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.7	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.1	GO:0090079	translation regulator activity, nucleic acid binding(GO:0090079)
0.0	0.0	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.0	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.0	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0008175	tRNA methyltransferase activity(GO:0008175)
0.0	0.1	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.2	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.0	GO:0016847	1-aminocyclopropane-1-carboxylate synthase activity(GO:0016847)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.2	GO:0030552	cAMP binding(GO:0030552)
0.0	0.0	GO:0005148	prolactin receptor binding(GO:0005148)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.4	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.3	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.6	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	PID ALK1 PATHWAY	ALK1 signaling events
0.8	PID FGF PATHWAY	FGF signaling pathway
1.1	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.4	PID AURORA A PATHWAY	Aurora A signaling
0.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.4	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.5	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	1.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.5	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.4	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.3	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.2	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.5	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.8	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.6	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.3	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	0.4	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.1	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.0	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.0	REACTOME HEMOSTASIS	Genes involved in Hemostasis
0.0	0.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.3	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.2	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.2	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	0.3	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis