Project
ENCODE: H3K4me3 ChIP-Seq of primary human cells
Navigation
Downloads
Logo

Results for POU4F1_POU4F3

Z-value: 1.20

Motif logo

logo of logo of

Transcription factors associated with POU4F1_POU4F3

Gene Symbol Gene ID Gene Info
POU4F1
ENSG00000152192.6 POU class 4 homeobox 1
POU4F3
ENSG00000091010.4 POU class 4 homeobox 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr13_79182716_79183828POU4F155990.1934980.551.2e-01Click!
chr13_79181751_79181902POU4F141530.2095650.531.4e-01Click!
chr13_79182558_79182709POU4F149600.1990430.472.0e-01Click!
chr13_79181975_79182128POU4F143780.2060920.452.2e-01Click!
chr13_79176958_79177133POU4F16280.709557-0.323.9e-01Click!
chr5_145719881_145720125POU4F314160.4674410.791.1e-02Click!
chr5_145724296_145724632POU4F358770.2314680.609.0e-02Click!
chr5_145725536_145725687POU4F370240.2236410.383.2e-01Click!
chr5_145725300_145725451POU4F367880.225019-0.088.4e-01Click!

Activity of the POU4F1_POU4F3 motif across conditions

Conditions sorted by the z-value of the POU4F1_POU4F3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_116833589_116833880 1.15 TRAPPC3L
 trafficking protein particle complex 3-like
 228
 0.83
chr12_91574306_91575101 0.70 DCN
 decorin
 50
 0.99
chr7_18549761_18549974 0.65 HDAC9
 histone deacetylase 9
 931
 0.71
chr9_22008020_22008450 0.62 CDKN2B
 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
 717
 0.61
chr17_46646430_46646725 0.62 HOXB3
 homeobox B3
 4808
 0.08
chr18_811181_811332 0.61 YES1
 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
 983
 0.49
chr11_111849006_111849202 0.60 DIXDC1
 DIX domain containing 1
 1071
 0.39
chr4_108746841_108747185 0.57 SGMS2
 sphingomyelin synthase 2
 649
 0.76
chr2_18481003_18481326 0.56 ENSG00000212455
 .
 259165
 0.02
chr1_162603392_162603656 0.55 DDR2
 discoidin domain receptor tyrosine kinase 2
 1264
 0.48
chr2_36581700_36582677 0.53 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 881
 0.74
chr6_100717098_100717249 0.51 RP1-121G13.2
157821
 0.04
chr11_86085513_86085741 0.51 CCDC81
 coiled-coil domain containing 81
 151
 0.96
chr9_89952337_89952906 0.51 ENSG00000212421
 .
 77256
 0.11
chr1_88928130_88928341 0.50 ENSG00000239504
 .
 15562
 0.29
chr11_68036812_68036963 0.50 C11orf24
 chromosome 11 open reading frame 24
 2528
 0.3
chr10_49812568_49813319 0.48 ARHGAP22
 Rho GTPase activating protein 22
 54
 0.98
chr6_47446841_47447070 0.48 CD2AP
 CD2-associated protein
 1430
 0.42
chr12_52258184_52258357 0.48 ANKRD33
 ankyrin repeat domain 33
 23474
 0.16
chr22_47241536_47241796 0.48 ENSG00000221672
 .
 2137
 0.4
chr15_48010788_48011252 0.48 SEMA6D
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
 334
 0.93
chr15_63050120_63050513 0.47 TLN2
 talin 2
 473
 0.82
chr9_97812256_97812766 0.47 ENSG00000207563
 .
 34979
 0.12
chr13_80912266_80912417 0.46 SPRY2
 sprouty homolog 2 (Drosophila)
 1453
 0.53
chr18_7572735_7572928 0.46 PTPRM
 protein tyrosine phosphatase, receptor type, M
 5014
 0.33
chr7_82070146_82070432 0.46 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 2742
 0.43
chr12_115119923_115120074 0.46 TBX3
 T-box 3
 1397
 0.48
chr16_27590300_27590451 0.46 KIAA0556
 KIAA0556
 5147
 0.22
chr5_141701461_141701673 0.46 SPRY4
 sprouty homolog 4 (Drosophila)
 2180
 0.34
chr13_76213551_76213793 0.45 LMO7
 LIM domain 7
 3213
 0.22
chr6_152701966_152702349 0.45 SYNE1-AS1
 SYNE1 antisense RNA 1
 476
 0.79
chr3_114477857_114478359 0.44 ZBTB20
 zinc finger and BTB domain containing 20
 10
 0.99
chr2_200446759_200446999 0.44 SATB2
 SATB homeobox 2
 110890
 0.07
chr3_79815928_79816150 0.43 ROBO1
 roundabout, axon guidance receptor, homolog 1 (Drosophila)
 926
 0.74
chr6_151597751_151597996 0.43 ENSG00000252431
 .
 3874
 0.18
chr7_123389891_123390042 0.42 RP11-390E23.6
844
 0.4
chr5_102202312_102202463 0.41 PAM
 peptidylglycine alpha-amidating monooxygenase
 567
 0.87
chr12_71054468_71054762 0.41 PTPRB
 protein tyrosine phosphatase, receptor type, B
 23395
 0.24
chr1_95389567_95389941 0.41 CNN3
 calponin 3, acidic
 1583
 0.36
chr8_97468793_97469144 0.40 ENSG00000202095
 .
 25580
 0.2
chr4_183413334_183413747 0.40 TENM3
 teneurin transmembrane protein 3
 43388
 0.17
chr19_55678355_55678541 0.39 ENSG00000239137
 .
 91
 0.81
chr6_72178134_72178480 0.39 ENSG00000207827
 .
 64983
 0.11
chr4_157891142_157892336 0.38 PDGFC
 platelet derived growth factor C
 316
 0.91
chr1_200148726_200148877 0.37 ENSG00000221403
 .
 34839
 0.21
chr3_13080776_13080942 0.36 IQSEC1
 IQ motif and Sec7 domain 1
 33758
 0.22
chr3_117454157_117454380 0.36 ENSG00000206889
 .
 191216
 0.03
chrX_138909289_138909440 0.36 ATP11C
 ATPase, class VI, type 11C
 5083
 0.25
chr2_26624476_26625174 0.36 DRC1
 dynein regulatory complex subunit 1 homolog (Chlamydomonas)
 41
 0.98
chr7_12811096_12811403 0.36 ENSG00000199470
 .
 70735
 0.11
chr17_8532417_8532568 0.36 MYH10
 myosin, heavy chain 10, non-muscle
 1543
 0.44
chr1_61692922_61693140 0.36 RP4-802A10.1
102626
 0.08
chr4_114897314_114897610 0.36 ARSJ
 arylsulfatase family, member J
 2690
 0.37
chr1_196620715_196621368 0.35 CFH
 complement factor H
 33
 0.98
chr2_242257443_242257594 0.35 HDLBP
 high density lipoprotein binding protein
 1042
 0.41
chr9_84947315_84947575 0.35 SPATA31D1
 SPATA31 subfamily D, member 1
 343758
 0.01
chrY_14922193_14922344 0.35 USP9Y
 ubiquitin specific peptidase 9, Y-linked
 36702
 0.22
chr12_91572375_91572546 0.35 DCN
 decorin
 131
 0.98
chr1_116089167_116089325 0.35 ENSG00000239984
 .
 59846
 0.11
chr1_66737250_66737924 0.35 PDE4B
 phosphodiesterase 4B, cAMP-specific
 14257
 0.29
chr6_169653692_169653887 0.35 THBS2
 thrombospondin 2
 350
 0.92
chr11_100587578_100587729 0.35 CTD-2383M3.1
28967
 0.17
chr6_127840298_127840479 0.34 SOGA3
 SOGA family member 3
 52
 0.98
chr2_218193929_218194080 0.34 ENSG00000251982
 .
 77725
 0.11
chr8_42072731_42073079 0.34 PLAT
 plasminogen activator, tissue
 7663
 0.16
chr6_152002769_152002982 0.34 ESR1
 estrogen receptor 1
 8756
 0.26
chr2_145787262_145787615 0.34 ENSG00000253036
 .
 305200
 0.01
chr8_18870397_18870669 0.34 PSD3
 pleckstrin and Sec7 domain containing 3
 663
 0.74
chr13_74862980_74863131 0.34 ENSG00000206617
 .
 296
 0.95
chr15_57512191_57512484 0.34 TCF12
 transcription factor 12
 673
 0.79
chr15_99788624_99789059 0.34 TTC23
 tetratricopeptide repeat domain 23
 895
 0.51
chr6_140373176_140373387 0.33 ENSG00000252107
 .
 106550
 0.08
chr11_9587935_9588242 0.33 WEE1
 WEE1 G2 checkpoint kinase
 7140
 0.16
chr2_202987834_202988283 0.33 AC079354.3
6277
 0.17
chr8_25317575_25317860 0.33 CDCA2
 cell division cycle associated 2
 1002
 0.5
chr2_226896266_226896823 0.33 NYAP2
 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
 622947
 0.0
chr10_63779003_63779237 0.33 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 29850
 0.22
chr7_66055880_66056152 0.33 KCTD7
 potassium channel tetramerization domain containing 7
 37852
 0.16
chr19_39186934_39187210 0.32 CTB-186G2.4
2826
 0.16
chr2_9348603_9349207 0.32 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 2011
 0.46
chr15_52123506_52123657 0.32 TMOD3
 tropomodulin 3 (ubiquitous)
 1754
 0.32
chr2_62934247_62934470 0.32 EHBP1
 EH domain binding protein 1
 31
 0.98
chr9_96932049_96932529 0.32 ENSG00000199165
 .
 5945
 0.16
chr18_9109419_9109570 0.32 NDUFV2
 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
 5414
 0.17
chr1_78471558_78472034 0.32 DNAJB4
 DnaJ (Hsp40) homolog, subfamily B, member 4
 1258
 0.34
chr2_33516384_33516581 0.32 LTBP1
 latent transforming growth factor beta binding protein 1
 233
 0.94
chr18_53144293_53144444 0.31 ENSG00000264571
 .
 2084
 0.31
chr15_37175433_37176047 0.31 ENSG00000212511
 .
 30899
 0.23
chr21_18376217_18376955 0.31 ENSG00000239023
 .
 285269
 0.01
chr6_109414275_109414426 0.31 SESN1
 sestrin 1
 1672
 0.32
chr13_33476928_33477100 0.31 KL
 klotho
 113193
 0.06
chr8_49831590_49831741 0.31 SNAI2
 snail family zinc finger 2
 2323
 0.45
chr5_10596142_10596297 0.31 ANKRD33B
 ankyrin repeat domain 33B
 31639
 0.16
chr1_8298719_8298899 0.30 ENSG00000200975
 .
 32152
 0.15
chr17_79317268_79317735 0.30 TMEM105
 transmembrane protein 105
 13027
 0.13
chr18_53253489_53253863 0.30 TCF4
 transcription factor 4
 326
 0.93
chr15_70819174_70819403 0.30 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 175332
 0.03
chr2_46928125_46928276 0.30 SOCS5
 suppressor of cytokine signaling 5
 1874
 0.38
chr2_219471971_219472122 0.30 PLCD4
 phospholipase C, delta 4
 442
 0.69
chr6_52925441_52925592 0.30 ICK
 intestinal cell (MAK-like) kinase
 1052
 0.42
chr3_185462581_185462876 0.29 ENSG00000265470
 .
 22964
 0.19
chr2_216298275_216298426 0.29 FN1
 fibronectin 1
 2440
 0.3
chrX_17395799_17395950 0.29 NHS
 Nance-Horan syndrome (congenital cataracts and dental anomalies)
 2331
 0.33
chr5_33794654_33794915 0.29 ENSG00000201623
 .
 93483
 0.08
chr3_60921693_60921844 0.29 ENSG00000212211
 .
 79491
 0.12
chr12_60131988_60132146 0.29 SLC16A7
 solute carrier family 16 (monocarboxylate transporter), member 7
 30773
 0.24
chr7_151328064_151328292 0.29 PRKAG2
 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
 1261
 0.55
chr9_126270533_126270733 0.28 RP11-230L22.4
16470
 0.24
chr3_191217380_191217807 0.28 PYDC2
 pyrin domain containing 2
 38641
 0.2
chr4_77703399_77704071 0.28 RP11-359D14.3
19382
 0.18
chr4_53966969_53967196 0.28 RP11-752D24.2
155226
 0.04
chr3_189735394_189735583 0.28 ENSG00000265045
 .
 96235
 0.07
chr15_77710162_77710461 0.28 PEAK1
 pseudopodium-enriched atypical kinase 1
 2131
 0.32
chr1_64240383_64241287 0.28 ROR1
 receptor tyrosine kinase-like orphan receptor 1
 1121
 0.63
chr7_28726429_28726958 0.28 CREB5
 cAMP responsive element binding protein 5
 1095
 0.68
chr5_60598656_60599005 0.27 ZSWIM6
 zinc finger, SWIM-type containing 6
 29270
 0.23
chr2_170591300_170591489 0.27 KLHL23
 kelch-like family member 23
 668
 0.64
chr8_119086940_119087091 0.27 EXT1
 exostosin glycosyltransferase 1
 35638
 0.24
chr1_215447400_215447702 0.27 KCNK2
 potassium channel, subfamily K, member 2
 190691
 0.03
chr2_219435817_219435968 0.27 RQCD1
 RCD1 required for cell differentiation1 homolog (S. pombe)
 2294
 0.17
chr11_46934289_46934467 0.27 LRP4
 low density lipoprotein receptor-related protein 4
 5795
 0.19
chr16_24697486_24697909 0.27 TNRC6A
 trinucleotide repeat containing 6A
 43319
 0.18
chr5_52707192_52707393 0.27 FST
 follistatin
 68947
 0.13
chr8_11382556_11382707 0.27 RP11-148O21.3
29085
 0.11
chr1_65730855_65731313 0.27 DNAJC6
 DnaJ (Hsp40) homolog, subfamily C, member 6
 647
 0.77
chr17_57230413_57230606 0.27 SKA2
 spindle and kinetochore associated complex subunit 2
 1347
 0.23
chr6_75913619_75913933 0.27 COL12A1
 collagen, type XII, alpha 1
 1268
 0.52
chr17_38708496_38708766 0.27 CCR7
 chemokine (C-C motif) receptor 7
 8634
 0.17
chr2_177418868_177419346 0.26 ENSG00000252027
 .
 110297
 0.06
chr9_75169048_75169276 0.26 ENSG00000238402
 .
 27010
 0.21
chr15_90543166_90543622 0.26 ZNF710
 zinc finger protein 710
 1230
 0.4
chr17_3572880_3573031 0.26 EMC6
 ER membrane protein complex subunit 6
 839
 0.33
chr3_9443823_9444009 0.26 SETD5-AS1
 SETD5 antisense RNA 1
 3653
 0.18
chr17_7156412_7156575 0.26 ELP5
 elongator acetyltransferase complex subunit 5
 551
 0.36
chr9_16704056_16704545 0.26 BNC2
 basonuclin 2
 780
 0.71
chr20_17947911_17948977 0.26 SNX5
 sorting nexin 5
 657
 0.53
chr2_24676770_24677172 0.26 NCOA1
 nuclear receptor coactivator 1
 37830
 0.18
chr1_68149789_68149968 0.26 GADD45A
 growth arrest and DNA-damage-inducible, alpha
 866
 0.65
chr11_18368890_18369041 0.26 GTF2H1
 general transcription factor IIH, polypeptide 1, 62kDa
 314
 0.84
chr4_170147421_170147572 0.26 RP11-327O17.2
24551
 0.22
chr6_113012091_113012242 0.26 ENSG00000252215
 .
 158782
 0.04
chr8_38242197_38242597 0.25 LETM2
 leucine zipper-EF-hand containing transmembrane protein 2
 1328
 0.3
chr10_76716977_76717128 0.25 RP11-77G23.5
66957
 0.1
chr18_20558047_20558453 0.25 RBBP8
 retinoblastoma binding protein 8
 9445
 0.15
chr1_17766506_17766801 0.25 RCC2
 regulator of chromosome condensation 2
 433
 0.8
chr13_66190370_66190521 0.25 ENSG00000221685
 .
 247860
 0.02
chr1_245329429_245329885 0.25 KIF26B
 kinesin family member 26B
 11370
 0.2
chr2_50371104_50371319 0.25 NRXN1
 neurexin 1
 124800
 0.06
chr8_15398472_15398721 0.25 TUSC3
 tumor suppressor candidate 3
 804
 0.72
chr10_119122644_119122795 0.25 ENSG00000222197
 .
 4852
 0.24
chr8_119120675_119121215 0.25 EXT1
 exostosin glycosyltransferase 1
 1708
 0.54
chr17_14028855_14029146 0.25 ENSG00000252305
 .
 51448
 0.12
chr8_118981794_118981945 0.25 EXT1
 exostosin glycosyltransferase 1
 140784
 0.05
chr3_150130220_150130998 0.25 TSC22D2
 TSC22 domain family, member 2
 1813
 0.47
chr15_38547811_38548278 0.25 SPRED1
 sprouty-related, EVH1 domain containing 1
 2662
 0.42
chr20_45114435_45114586 0.25 ZNF334
 zinc finger protein 334
 20499
 0.19
chr11_102039159_102039310 0.25 YAP1
 Yes-associated protein 1
 17578
 0.19
chr10_117930701_117930852 0.24 GFRA1
 GDNF family receptor alpha 1
 84531
 0.1
chr21_17792662_17793003 0.24 ENSG00000207638
 .
 118577
 0.06
chr22_40673331_40673671 0.24 TNRC6B
 trinucleotide repeat containing 6B
 12494
 0.23
chr6_75316769_75316920 0.24 ENSG00000264884
 .
 112715
 0.07
chr18_20139314_20139465 0.24 ENSG00000206827
 .
 88156
 0.09
chr14_100260565_100260825 0.24 EML1
 echinoderm microtubule associated protein like 1
 923
 0.67
chr7_66120646_66120797 0.24 RP4-756H11.3
1148
 0.52
chr3_25193430_25193657 0.24 RARB
 retinoic acid receptor, beta
 22280
 0.26
chr4_74316638_74316988 0.24 AFP
 alpha-fetoprotein
 14849
 0.2
chr8_124281132_124281572 0.24 ZHX1-C8ORF76
 ZHX1-C8ORF76 readthrough
 1725
 0.21
chr6_49294723_49295128 0.24 ENSG00000252457
 .
 17596
 0.27
chr20_18446613_18446764 0.24 DZANK1
 double zinc ribbon and ankyrin repeat domains 1
 663
 0.48
chr6_27060216_27060434 0.24 ENSG00000222800
 .
 17434
 0.13
chr5_54456050_54456451 0.24 GPX8
 glutathione peroxidase 8 (putative)
 252
 0.86
chr18_60905231_60905454 0.24 ENSG00000238988
 .
 43444
 0.14
chr11_82570104_82570255 0.24 PRCP
 prolylcarboxypeptidase (angiotensinase C)
 366
 0.88
chr6_45448601_45449137 0.24 RUNX2
 runt-related transcription factor 2
 58647
 0.13
chr7_44801800_44801951 0.24 ZMIZ2
 zinc finger, MIZ-type containing 2
 6071
 0.17
chr2_151091538_151091758 0.24 RND3
 Rho family GTPase 3
 250248
 0.02
chr17_46240634_46240785 0.24 ENSG00000221739
 .
 6836
 0.12
chr7_80547175_80548098 0.24 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 863
 0.76
chr2_67620410_67620561 0.24 ETAA1
 Ewing tumor-associated antigen 1
 3966
 0.38
chr5_140940128_140940366 0.24 CTD-2024I7.13
2369
 0.19
chr9_81217104_81217255 0.23 PSAT1
 phosphoserine aminotransferase 1
 305120
 0.01
chr14_31464257_31464552 0.23 ENSG00000207952
 .
 19544
 0.17
chr1_178836761_178836994 0.23 ANGPTL1
 angiopoietin-like 1
 1536
 0.43
chr10_79397825_79398297 0.23 KCNMA1
 potassium large conductance calcium-activated channel, subfamily M, alpha member 1
 66
 0.98
chr12_109195839_109196070 0.23 ENSG00000264043
 .
 23907
 0.13
chr10_89917929_89918366 0.23 ENSG00000200891
 .
 163695
 0.04
chr18_55889348_55889572 0.23 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
 657
 0.77
chr15_88020923_88021173 0.23 ENSG00000207150
 .
 3528
 0.4
chr14_95963717_95963868 0.23 RP11-1070N10.3
 Uncharacterized protein
 18681
 0.14
chr11_89113858_89114276 0.23 NOX4
 NADPH oxidase 4
 109833
 0.07
chr1_110693882_110694033 0.23 SLC6A17
 solute carrier family 6 (neutral amino acid transporter), member 17
 849
 0.49
chr2_110366652_110366826 0.23 AC011753.5
3464
 0.22
chr2_70518346_70518567 0.23 SNRPG
 small nuclear ribonucleoprotein polypeptide G
 1452
 0.31
chr9_694286_694821 0.23 RP11-130C19.3
8998
 0.22
chr3_106059964_106060303 0.23 ENSG00000200610
 .
 174611
 0.04
chr21_34918443_34918594 0.23 GART
 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
 2721
 0.18
chr11_108777750_108777901 0.23 ENSG00000201243
 .
 98419
 0.08
chr17_35851874_35852313 0.23 DUSP14
 dual specificity phosphatase 14
 523
 0.79
chr8_62621050_62621416 0.23 ASPH
 aspartate beta-hydroxylase
 5851
 0.24
chr20_33907930_33908081 0.22 FAM83C
 family with sequence similarity 83, member C
 27801
 0.09

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F1_POU4F3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 0.4 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.5 GO:0060437 lung growth(GO:0060437)
0.1 0.4 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.1 0.3 GO:0071692 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 0.3 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.1 0.5 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.4 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.1 0.2 GO:0060596 mammary placode formation(GO:0060596)
0.1 0.2 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.1 0.2 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.1 0.2 GO:0010842 retina layer formation(GO:0010842)
0.1 0.1 GO:0060594 mammary gland specification(GO:0060594)
0.1 0.1 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.1 0.2 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 0.1 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.1 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.2 GO:0031394 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.2 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.5 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.2 GO:0042023 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.2 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:0060751 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.0 0.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.4 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.1 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.1 GO:0032641 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0 0.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.1 GO:0032328 alanine transport(GO:0032328)
0.0 0.1 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0090195 chemokine secretion(GO:0090195) regulation of chemokine secretion(GO:0090196) positive regulation of chemokine secretion(GO:0090197)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0006188 IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.1 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.1 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.0 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.3 GO:0031000 response to caffeine(GO:0031000)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0045628 regulation of T-helper 2 cell differentiation(GO:0045628)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.0 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.0 GO:0060687 regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.0 0.3 GO:0043114 regulation of vascular permeability(GO:0043114)
0.0 0.1 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.2 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0072124 glomerular mesangial cell proliferation(GO:0072110) regulation of glomerular mesangial cell proliferation(GO:0072124)
0.0 0.2 GO:0006907 pinocytosis(GO:0006907)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.0 GO:1902337 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) regulation of apoptotic process involved in morphogenesis(GO:1902337) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747) regulation of apoptotic process involved in development(GO:1904748)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.3 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.0 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.0 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.0 GO:0060998 regulation of dendritic spine development(GO:0060998)
0.0 0.0 GO:0044557 relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.2 GO:0007616 long-term memory(GO:0007616)
0.0 0.1 GO:0032376 positive regulation of sterol transport(GO:0032373) positive regulation of cholesterol transport(GO:0032376)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0031033 myosin filament organization(GO:0031033)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.2 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.5 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.1 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.0 GO:0014056 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.0 0.1 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.3 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.0 GO:0030146 obsolete diuresis(GO:0030146)
0.0 0.1 GO:0010560 positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0 0.4 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.3 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.1 GO:0018243 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:2000144 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.1 GO:0048935 peripheral nervous system neuron development(GO:0048935)
0.0 0.0 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.0 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.0 0.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.0 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.1 GO:0008634 obsolete negative regulation of survival gene product expression(GO:0008634)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.1 GO:0009169 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.0 GO:0032288 myelin assembly(GO:0032288)
0.0 0.1 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.2 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.0 GO:0090036 regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.0 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.2 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.0 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.0 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.0 GO:0060298 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742) positive regulation of sarcomere organization(GO:0060298)
0.0 0.0 GO:0051014 actin filament severing(GO:0051014)
0.0 0.0 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.0 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0 0.0 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.2 GO:0050999 regulation of nitric-oxide synthase activity(GO:0050999)
0.0 0.0 GO:0051140 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.0 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.0 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.2 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 0.1 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.0 0.5 GO:0007043 cell-cell junction assembly(GO:0007043)
0.0 0.0 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.0 GO:0001696 gastric acid secretion(GO:0001696)
0.0 0.0 GO:0003148 outflow tract septum morphogenesis(GO:0003148)
0.0 0.0 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:1901983 regulation of histone acetylation(GO:0035065) regulation of protein acetylation(GO:1901983) regulation of peptidyl-lysine acetylation(GO:2000756)
0.0 0.1 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.0 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.3 GO:0007098 centrosome cycle(GO:0007098)
0.0 0.0 GO:0014721 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0 0.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.0 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.0 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.0 GO:0050686 negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0001893 maternal placenta development(GO:0001893)
0.0 0.1 GO:0070071 proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0 0.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.3 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.2 GO:0032449 CBM complex(GO:0032449)
0.0 0.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.1 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.2 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.3 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.0 GO:0044291 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0032156 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0034704 calcium channel complex(GO:0034704)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.0 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.0 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.9 GO:0060076 excitatory synapse(GO:0060076)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0043205 fibril(GO:0043205)
0.0 0.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.8 GO:0001726 ruffle(GO:0001726)
0.0 0.9 GO:0034705 potassium channel complex(GO:0034705)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.2 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 0.5 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.5 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.3 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 0.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.3 GO:0030172 troponin C binding(GO:0030172)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.1 GO:0070052 collagen V binding(GO:0070052)
0.1 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.4 GO:0046970 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0016595 glutamate binding(GO:0016595)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.0 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.2 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.2 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.0 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.4 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0048185 activin binding(GO:0048185)
0.0 0.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.0 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.0 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.1 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.0 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.7 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.0 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.1 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.1 GO:0090079 translation regulator activity, nucleic acid binding(GO:0090079)
0.0 0.0 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.0 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.0 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.0 GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity(GO:0016847)
0.0 0.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.0 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0030552 cAMP binding(GO:0030552)
0.0 0.0 GO:0005148 prolactin receptor binding(GO:0005148)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.1 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.0 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.8 PID FGF PATHWAY FGF signaling pathway
0.0 1.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling
0.0 0.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.1 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 1.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.1 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.1 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.0 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.0 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis