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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for POU4F2

Z-value: 0.93

Motif logo

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU class 4 homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr4_147559572_147559723POU4F23980.6993610.571.1e-01Click!
chr4_147559365_147559516POU4F26050.6002090.393.0e-01Click!

Activity of the POU4F2 motif across conditions

Conditions sorted by the z-value of the POU4F2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_130587727_130588114 0.53 ENSG00000226380
 .
 25622
 0.22
chr12_86229562_86230264 0.52 RASSF9
 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
 435
 0.89
chr18_55889704_55889927 0.48 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
 1012
 0.61
chr8_55294582_55295235 0.47 ENSG00000244107
 .
 38120
 0.17
chr14_29243474_29243665 0.46 C14orf23
 chromosome 14 open reading frame 23
 1568
 0.33
chr20_14315841_14316127 0.45 FLRT3
 fibronectin leucine rich transmembrane protein 3
 2270
 0.36
chr18_8707466_8707765 0.45 RP11-674N23.1
4
 0.73
chr3_98700853_98701271 0.45 ENSG00000207331
 .
 73759
 0.1
chr1_48484300_48484451 0.44 TRABD2B
 TraB domain containing 2B
 21808
 0.25
chr21_28215844_28216573 0.43 ADAMTS1
 ADAM metallopeptidase with thrombospondin type 1 motif, 1
 112
 0.98
chr8_37350646_37351319 0.41 RP11-150O12.6
23557
 0.24
chr16_27590300_27590451 0.41 KIAA0556
 KIAA0556
 5147
 0.22
chr4_77611462_77611724 0.41 AC107072.2
52817
 0.12
chr3_98624953_98625332 0.40 ENSG00000207331
 .
 2161
 0.28
chr12_3226358_3226555 0.39 TSPAN9-IT1
 TSPAN9 intronic transcript 1 (non-protein coding)
 32507
 0.17
chr15_49716998_49717158 0.38 FGF7
 fibroblast growth factor 7
 1621
 0.44
chr9_22239467_22239618 0.38 CDKN2B-AS1
 CDKN2B antisense RNA 1
 125865
 0.06
chr3_105657205_105657471 0.36 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
 68942
 0.15
chr5_169398359_169398694 0.36 FAM196B
 family with sequence similarity 196, member B
 9218
 0.26
chr18_7572556_7572707 0.35 PTPRM
 protein tyrosine phosphatase, receptor type, M
 4814
 0.33
chr15_99297407_99297593 0.34 ENSG00000264480
 .
 30155
 0.19
chr4_168818614_168818765 0.33 ANXA10
 annexin A10
 194977
 0.03
chr2_151335102_151335779 0.33 RND3
 Rho family GTPase 3
 6456
 0.35
chr7_1443631_1443991 0.33 MICALL2
 MICAL-like 2
 55151
 0.11
chr2_203882992_203883167 0.32 NBEAL1
 neurobeachin-like 1
 3477
 0.29
chr14_39961289_39961440 0.32 FBXO33
 F-box protein 33
 59660
 0.14
chr10_33622034_33622426 0.32 NRP1
 neuropilin 1
 1080
 0.63
chr20_48760619_48760901 0.31 TMEM189-UBE2V1
 TMEM189-UBE2V1 readthrough
 9414
 0.17
chr10_14730521_14730672 0.31 ENSG00000201766
 .
 25103
 0.19
chrX_135230667_135231011 0.31 FHL1
 four and a half LIM domains 1
 102
 0.97
chr7_134330319_134330562 0.30 BPGM
 2,3-bisphosphoglycerate mutase
 1120
 0.61
chr2_216484448_216484719 0.30 AC012462.1
183607
 0.03
chr11_106239153_106239583 0.30 RP11-680E19.1
104326
 0.08
chr3_75955654_75955867 0.30 ROBO2
 roundabout, axon guidance receptor, homolog 2 (Drosophila)
 86
 0.98
chr5_143138706_143138857 0.30 HMHB1
 histocompatibility (minor) HB-1
 52945
 0.16
chr5_141701461_141701673 0.29 SPRY4
 sprouty homolog 4 (Drosophila)
 2180
 0.34
chr8_66629390_66629680 0.29 RP11-707M3.3
2522
 0.31
chr16_64425240_64425489 0.29 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 668217
 0.0
chr9_21973547_21973827 0.29 CDKN2A
 cyclin-dependent kinase inhibitor 2A
 1170
 0.41
chr8_41165312_41165463 0.29 SFRP1
 secreted frizzled-related protein 1
 878
 0.57
chr10_6763782_6764322 0.29 PRKCQ
 protein kinase C, theta
 141789
 0.05
chr6_170596064_170596215 0.29 DLL1
 delta-like 1 (Drosophila)
 3422
 0.21
chr12_26266071_26266589 0.29 SSPN
 sarcospan
 8594
 0.18
chr3_41244711_41244955 0.29 CTNNB1
 catenin (cadherin-associated protein), beta 1, 88kDa
 3231
 0.41
chr11_2834821_2835116 0.28 KCNQ1-AS1
 KCNQ1 antisense RNA 1
 47830
 0.11
chr6_160457314_160457599 0.28 AIRN
 antisense of IGF2R non-protein coding RNA
 28760
 0.19
chr1_24621564_24621715 0.27 ENSG00000266511
 .
 15294
 0.15
chr12_52301279_52301690 0.27 ACVRL1
 activin A receptor type II-like 1
 282
 0.9
chr7_17720120_17720505 0.27 SNX13
 sorting nexin 13
 259779
 0.02
chr6_28442401_28443147 0.27 ZSCAN23
 zinc finger and SCAN domain containing 23
 31530
 0.13
chr6_69158334_69158485 0.27 ENSG00000266675
 .
 44922
 0.21
chr7_42145445_42145596 0.27 GLI3
 GLI family zinc finger 3
 121800
 0.07
chr1_116472827_116472978 0.26 SLC22A15
 solute carrier family 22, member 15
 46217
 0.16
chr9_9701186_9701337 0.26 ENSG00000265735
 .
 259201
 0.02
chr21_29050610_29050761 0.26 ADAMTS5
 ADAM metallopeptidase with thrombospondin type 1 motif, 5
 711853
 0.0
chr3_73085691_73085907 0.26 ENSG00000238959
 .
 8840
 0.16
chr5_134914483_134914805 0.26 CXCL14
 chemokine (C-X-C motif) ligand 14
 110
 0.67
chr16_82049841_82049992 0.26 SDR42E1
 short chain dehydrogenase/reductase family 42E, member 1
 4823
 0.21
chr5_78808053_78808300 0.26 HOMER1
 homer homolog 1 (Drosophila)
 441
 0.86
chr17_15301686_15301923 0.26 ENSG00000239888
 .
 9897
 0.2
chr12_47097195_47097346 0.26 SLC38A4
 solute carrier family 38, member 4
 65817
 0.15
chr15_33130691_33130971 0.25 FMN1
 formin 1
 49624
 0.13
chr6_7544134_7544343 0.25 DSP
 desmoplakin
 2388
 0.28
chr4_181928076_181928259 0.25 ENSG00000251742
 .
 828094
 0.0
chr9_22239273_22239447 0.25 CDKN2B-AS1
 CDKN2B antisense RNA 1
 125683
 0.06
chr17_42214986_42215221 0.25 ENSG00000212446
 .
 1746
 0.18
chr8_57122510_57122859 0.25 PLAG1
 pleiomorphic adenoma gene 1
 1154
 0.41
chr15_59663421_59663716 0.25 FAM81A
 family with sequence similarity 81, member A
 1324
 0.28
chr10_60275835_60276146 0.24 BICC1
 bicaudal C homolog 1 (Drosophila)
 3090
 0.38
chr11_131780111_131780399 0.24 NTM
 neurotrimin
 642
 0.77
chr9_108212044_108212195 0.24 FSD1L
 fibronectin type III and SPRY domain containing 1-like
 1715
 0.48
chr4_78093910_78094061 0.24 CCNG2
 cyclin G2
 14406
 0.22
chr21_36749606_36749887 0.24 RUNX1
 runt-related transcription factor 1
 328105
 0.01
chr1_68214173_68214559 0.24 ENSG00000238778
 .
 23970
 0.19
chr13_27936373_27936791 0.24 ENSG00000252247
 .
 18699
 0.15
chr10_116443956_116444184 0.23 ABLIM1
 actin binding LIM protein 1
 344
 0.91
chr11_85436820_85436971 0.23 SYTL2
 synaptotagmin-like 2
 616
 0.73
chr4_157691847_157691998 0.23 RP11-154F14.2
70589
 0.11
chr9_4137636_4137913 0.23 GLIS3
 GLIS family zinc finger 3
 7419
 0.28
chr1_100111779_100111966 0.23 PALMD
 palmdelphin
 123
 0.98
chr10_68587107_68587258 0.23 LRRTM3
 leucine rich repeat transmembrane neuronal 3
 98582
 0.09
chr7_70201396_70202343 0.23 AUTS2
 autism susceptibility candidate 2
 7744
 0.34
chrX_114859841_114860486 0.23 PLS3
 plastin 3
 13867
 0.21
chr9_18472965_18473116 0.22 ADAMTSL1
 ADAMTS-like 1
 852
 0.75
chr1_85247835_85247986 0.22 ENSG00000251899
 .
 10972
 0.25
chr3_112931196_112931871 0.22 BOC
 BOC cell adhesion associated, oncogene regulated
 124
 0.97
chr13_68202936_68203087 0.22 PCDH9
 protocadherin 9
 398543
 0.01
chr14_55569037_55569677 0.22 LGALS3
 lectin, galactoside-binding, soluble, 3
 21471
 0.19
chr5_21818159_21818310 0.22 ENSG00000221615
 .
 83914
 0.11
chr4_149087033_149087184 0.22 RP11-76G10.1
19486
 0.29
chr6_138430146_138430297 0.22 PERP
 PERP, TP53 apoptosis effector
 1573
 0.49
chr16_86599945_86600151 0.22 FOXC2
 forkhead box C2 (MFH-1, mesenchyme forkhead 1)
 809
 0.48
chr3_170807489_170807640 0.22 ENSG00000207963
 .
 16984
 0.23
chr3_58983787_58983938 0.21 C3orf67
 chromosome 3 open reading frame 67
 51855
 0.18
chr3_155570793_155570970 0.21 SLC33A1
 solute carrier family 33 (acetyl-CoA transporter), member 1
 399
 0.87
chr11_9587935_9588242 0.21 WEE1
 WEE1 G2 checkpoint kinase
 7140
 0.16
chr12_18841597_18841748 0.21 PLCZ1
 phospholipase C, zeta 1
 6299
 0.25
chr6_140065137_140065288 0.21 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 369455
 0.01
chr2_163171316_163171467 0.21 IFIH1
 interferon induced with helicase C domain 1
 3803
 0.25
chr4_89532288_89532605 0.21 HERC3
 HECT and RLD domain containing E3 ubiquitin protein ligase 3
 5501
 0.2
chr21_17909068_17909746 0.21 ENSG00000207638
 .
 2002
 0.33
chr1_229506200_229506351 0.20 ENSG00000252506
 .
 12600
 0.14
chr8_18870397_18870669 0.20 PSD3
 pleckstrin and Sec7 domain containing 3
 663
 0.74
chr15_96886136_96886425 0.20 ENSG00000222651
 .
 9790
 0.16
chr2_184434080_184434231 0.20 ENSG00000238306
 .
 380008
 0.01
chr21_34918443_34918594 0.20 GART
 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
 2721
 0.18
chr13_52218829_52218980 0.20 ENSG00000242893
 .
 50553
 0.11
chr15_101668711_101668940 0.20 RP11-505E24.2
42554
 0.16
chr22_45406041_45406799 0.20 PHF21B
 PHD finger protein 21B
 540
 0.81
chr11_127461004_127461155 0.19 ENSG00000223315
 .
 183333
 0.03
chr2_46561817_46561968 0.19 EPAS1
 endothelial PAS domain protein 1
 37351
 0.19
chr10_77648848_77649145 0.19 ENSG00000215921
 .
 65460
 0.13
chr7_28355289_28355446 0.19 CREB5
 cAMP responsive element binding protein 5
 16427
 0.26
chr2_39751073_39751342 0.19 AC007246.3
5391
 0.29
chr17_58821066_58821723 0.19 ENSG00000252534
 .
 5013
 0.22
chr3_112803505_112803695 0.19 ENSG00000238593
 .
 7772
 0.2
chr17_65240369_65240671 0.19 RP11-401F2.3
433
 0.62
chr1_164532131_164532342 0.19 PBX1
 pre-B-cell leukemia homeobox 1
 194
 0.97
chr6_113734377_113734528 0.19 ENSG00000222677
 .
 101737
 0.08
chr10_69831641_69832005 0.19 HERC4
 HECT and RLD domain containing E3 ubiquitin protein ligase 4
 2071
 0.33
chr7_73246766_73246917 0.19 CLDN4
 claudin 4
 1648
 0.31
chr6_108486676_108487297 0.19 OSTM1
 osteopetrosis associated transmembrane protein 1
 58
 0.78
chr12_56917781_56918152 0.19 RBMS2
 RNA binding motif, single stranded interacting protein 2
 2183
 0.23
chr4_183370400_183371073 0.19 TENM3
 teneurin transmembrane protein 3
 584
 0.84
chr7_32929941_32930760 0.19 KBTBD2
 kelch repeat and BTB (POZ) domain containing 2
 415
 0.87
chr8_59027426_59027596 0.18 FAM110B
 family with sequence similarity 110, member B
 120398
 0.07
chr2_52845575_52845726 0.18 ENSG00000264975
 .
 84103
 0.11
chr1_70672840_70672991 0.18 SRSF11
 serine/arginine-rich splicing factor 11
 1497
 0.3
chr2_163157606_163157781 0.18 IFIH1
 interferon induced with helicase C domain 1
 17501
 0.19
chr5_135470545_135470952 0.18 SMAD5-AS1
 SMAD5 antisense RNA 1
 169
 0.92
chr3_189509857_189510008 0.18 TP63
 tumor protein p63
 2342
 0.39
chr7_17701857_17702150 0.18 SNX13
 sorting nexin 13
 278088
 0.01
chr7_70048822_70048973 0.18 AUTS2
 autism susceptibility candidate 2
 145228
 0.05
chr21_24278413_24278564 0.18 ENSG00000263796
 .
 225496
 0.02
chr2_200446222_200446758 0.18 SATB2
 SATB homeobox 2
 110501
 0.07
chr7_150785302_150785601 0.18 AGAP3
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
 1297
 0.25
chr8_94931050_94931201 0.18 PDP1
 pyruvate dehyrogenase phosphatase catalytic subunit 1
 13
 0.98
chr13_24782412_24782563 0.18 SPATA13
 spermatogenesis associated 13
 43345
 0.13
chr4_14728626_14728777 0.18 ENSG00000202449
 .
 36367
 0.24
chr14_27067998_27068288 0.18 NOVA1-AS1
 NOVA1 antisense RNA 1 (head to head)
 525
 0.68
chr10_79265125_79265301 0.18 ENSG00000199592
 .
 81594
 0.1
chr11_103677106_103677422 0.17 ENSG00000264200
 .
 43370
 0.2
chr3_159484310_159484461 0.17 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 1493
 0.34
chr6_16737749_16737900 0.17 RP1-151F17.1
23545
 0.22
chr5_87780535_87780686 0.17 TMEM161B-AS1
 TMEM161B antisense RNA 1
 58098
 0.14
chr16_54968513_54968925 0.17 IRX5
 iroquois homeobox 5
 2735
 0.43
chr8_10568187_10568338 0.17 CTD-2135J3.3
18562
 0.12
chr12_104613330_104613526 0.17 TXNRD1
 thioredoxin reductase 1
 3869
 0.26
chr3_124421533_124421684 0.17 ENSG00000263775
 .
 5725
 0.16
chr2_37798390_37798541 0.17 AC006369.2
28814
 0.21
chr4_148657265_148657705 0.17 ARHGAP10
 Rho GTPase activating protein 10
 4271
 0.21
chr3_159483781_159484285 0.17 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 1141
 0.44
chr10_16992831_16993197 0.17 CUBN
 cubilin (intrinsic factor-cobalamin receptor)
 33180
 0.22
chr15_33154166_33154394 0.17 FMN1
 formin 1
 26175
 0.19
chr3_185446261_185446412 0.17 C3orf65
 chromosome 3 open reading frame 65
 15256
 0.21
chr9_111249319_111249470 0.17 ENSG00000222512
 .
 128185
 0.06
chr22_36232810_36232961 0.17 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 3380
 0.35
chr7_80542898_80543049 0.17 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 5526
 0.35
chr5_79542586_79542846 0.17 ENSG00000239159
 .
 7308
 0.19
chr5_109671354_109671505 0.17 ENSG00000221436
 .
 178187
 0.03
chr1_149378983_149379172 0.16 FCGR1C
 Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene
 9720
 0.13
chr20_19966352_19966503 0.16 NAA20
 N(alpha)-acetyltransferase 20, NatB catalytic subunit
 31333
 0.18
chr18_66505598_66505749 0.16 CCDC102B
 coiled-coil domain containing 102B
 1672
 0.41
chr2_233453880_233454031 0.16 AC073254.1
2577
 0.17
chr14_88738980_88739131 0.16 KCNK10
 potassium channel, subfamily K, member 10
 1800
 0.48
chr5_92918170_92918321 0.16 NR2F1
 nuclear receptor subfamily 2, group F, member 1
 798
 0.54
chr19_56332953_56333104 0.16 NLRP11
 NLR family, pyrin domain containing 11
 3425
 0.16
chrX_107680802_107681081 0.16 COL4A6
 collagen, type IV, alpha 6
 615
 0.74
chr15_101069679_101069830 0.16 CERS3
 ceramide synthase 3
 14722
 0.15
chr11_12696722_12697409 0.16 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
 15
 0.99
chr1_68686585_68686736 0.16 WLS
 wntless Wnt ligand secretion mediator
 10710
 0.23
chr18_59665868_59666178 0.16 RNF152
 ring finger protein 152
 104559
 0.07
chr1_203648008_203648159 0.16 ATP2B4
 ATPase, Ca++ transporting, plasma membrane 4
 3854
 0.27
chr17_35851593_35851869 0.16 DUSP14
 dual specificity phosphatase 14
 161
 0.96
chr1_191327786_191327937 0.16 RGS18
 regulator of G-protein signaling 18
 799726
 0.0
chr6_114181963_114182196 0.16 MARCKS
 myristoylated alanine-rich protein kinase C substrate
 3538
 0.24
chr6_125420988_125421372 0.16 TPD52L1
 tumor protein D52-like 1
 19015
 0.24
chr10_5005306_5005493 0.16 AKR1C1
 aldo-keto reductase family 1, member C1
 46
 0.92
chr3_58038318_58038519 0.16 FLNB
 filamin B, beta
 25638
 0.22
chr2_205529494_205529645 0.16 PARD3B
 par-3 family cell polarity regulator beta
 118846
 0.07
chr1_178027513_178027706 0.16 RASAL2
 RAS protein activator like 2
 35255
 0.22
chr15_74880905_74881056 0.16 CLK3
 CDC-like kinase 3
 19733
 0.14
chr15_96897591_96898313 0.15 AC087477.1
 Uncharacterized protein
 6535
 0.18
chr10_5045552_5046386 0.15 AKR1C2
 aldo-keto reductase family 1, member C2
 83
 0.93
chr17_69531749_69531900 0.15 ENSG00000222563
 .
 224515
 0.02
chr9_71790192_71790670 0.15 TJP2
 tight junction protein 2
 1221
 0.59
chr17_63550102_63550306 0.15 AXIN2
 axin 2
 4643
 0.32
chr5_123149834_123150053 0.15 CSNK1G3
 casein kinase 1, gamma 3
 225824
 0.02
chr3_197121898_197122049 0.15 ENSG00000238491
 .
 55551
 0.12
chr20_30309971_30310242 0.15 BCL2L1
 BCL2-like 1
 245
 0.84
chr4_152331570_152331721 0.15 FAM160A1
 family with sequence similarity 160, member A1
 1141
 0.61
chr18_53067170_53067321 0.15 TCF4
 transcription factor 4
 1321
 0.53
chr1_55183020_55183171 0.15 TTC4
 tetratricopeptide repeat domain 4
 1600
 0.36
chr3_98605225_98605614 0.15 DCBLD2
 discoidin, CUB and LCCL domain containing 2
 14596
 0.17
chr4_44656889_44657040 0.15 YIPF7
 Yip1 domain family, member 7
 3306
 0.24
chr2_179144221_179144372 0.15 OSBPL6
 oxysterol binding protein-like 6
 5358
 0.27
chr1_220527416_220527567 0.15 AC096644.1
 Uncharacterized protein
 80532
 0.09
chr10_74600201_74600352 0.15 OIT3
 oncoprotein induced transcript 3
 53063
 0.12
chr3_87036535_87037613 0.15 VGLL3
 vestigial like 3 (Drosophila)
 2778
 0.42
chr5_124820548_124820891 0.15 ENSG00000222107
 .
 133895
 0.06

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.1 0.3 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.3 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 0.2 GO:0071504 cellular response to heparin(GO:0071504)
0.1 0.2 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1 0.4 GO:0060347 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.1 0.1 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.1 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.1 0.2 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.1 0.1 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.1 GO:0072141 mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0 0.0 GO:0003160 endocardium development(GO:0003157) endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214)
0.0 0.1 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.1 GO:0045605 negative regulation of epidermal cell differentiation(GO:0045605)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.0 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.2 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.0 0.2 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.2 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.1 GO:0071681 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0 0.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus(GO:0002866)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.1 GO:0010662 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.1 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.2 GO:0048821 erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0 0.1 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.0 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.2 GO:0050812 acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0 0.1 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.0 GO:0051014 actin filament severing(GO:0051014)
0.0 0.3 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.0 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.0 0.0 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:0008038 neuron recognition(GO:0008038)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0046639 negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.0 GO:0060900 embryonic camera-type eye formation(GO:0060900)
0.0 0.1 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.0 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.1 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.1 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.1 GO:0002068 glandular epithelial cell development(GO:0002068)
0.0 0.0 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.0 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.0 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:1903053 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.0 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0060174 limb bud formation(GO:0060174)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.0 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.0 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.0 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.0 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.5 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.3 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.0 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.0 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0032589 neuron projection membrane(GO:0032589)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.3 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.2 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.2 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.3 GO:0045296 cadherin binding(GO:0045296)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.0 GO:0019863 IgE binding(GO:0019863)
0.0 0.0 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.2 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.0 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.0 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.0 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.0 GO:0070324 thyroid hormone binding(GO:0070324)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME SIGNALING BY FGFR IN DISEASE Genes involved in Signaling by FGFR in disease
0.0 0.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network