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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for POU4F2

Z-value: 0.93

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Transcription factors associated with POU4F2

Gene Symbol	Gene ID	Gene Info
POU4F2 Ensembl NCBI GeneCards UniProt	ENSG00000151615.3	POU4F2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
POU4F2	chr4_147559572_147559723	398	0.699361	0.57	1.1e-01	Click!
POU4F2	chr4_147559365_147559516	605	0.600209	0.39	3.0e-01	Click!

Activity of the POU4F2 motif across conditions

Conditions sorted by the z-value of the POU4F2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_130587727_130588114	0.53	ENSG00000226380	.	25622	0.22
chr12_86229562_86230264	0.52	RASSF9	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	435	0.89
chr18_55889704_55889927	0.48	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	1012	0.61
chr8_55294582_55295235	0.47	ENSG00000244107	.	38120	0.17
chr14_29243474_29243665	0.46	C14orf23	chromosome 14 open reading frame 23	1568	0.33
chr20_14315841_14316127	0.45	FLRT3	fibronectin leucine rich transmembrane protein 3	2270	0.36
chr18_8707466_8707765	0.45	RP11-674N23.1		4	0.73
chr3_98700853_98701271	0.45	ENSG00000207331	.	73759	0.1
chr1_48484300_48484451	0.44	TRABD2B	TraB domain containing 2B	21808	0.25
chr21_28215844_28216573	0.43	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	112	0.98
chr8_37350646_37351319	0.41	RP11-150O12.6		23557	0.24
chr16_27590300_27590451	0.41	KIAA0556	KIAA0556	5147	0.22
chr4_77611462_77611724	0.41	AC107072.2		52817	0.12
chr3_98624953_98625332	0.40	ENSG00000207331	.	2161	0.28
chr12_3226358_3226555	0.39	TSPAN9-IT1	TSPAN9 intronic transcript 1 (non-protein coding)	32507	0.17
chr15_49716998_49717158	0.38	FGF7	fibroblast growth factor 7	1621	0.44
chr9_22239467_22239618	0.38	CDKN2B-AS1	CDKN2B antisense RNA 1	125865	0.06
chr3_105657205_105657471	0.36	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	68942	0.15
chr5_169398359_169398694	0.36	FAM196B	family with sequence similarity 196, member B	9218	0.26
chr18_7572556_7572707	0.35	PTPRM	protein tyrosine phosphatase, receptor type, M	4814	0.33
chr15_99297407_99297593	0.34	ENSG00000264480	.	30155	0.19
chr4_168818614_168818765	0.33	ANXA10	annexin A10	194977	0.03
chr2_151335102_151335779	0.33	RND3	Rho family GTPase 3	6456	0.35
chr7_1443631_1443991	0.33	MICALL2	MICAL-like 2	55151	0.11
chr2_203882992_203883167	0.32	NBEAL1	neurobeachin-like 1	3477	0.29
chr14_39961289_39961440	0.32	FBXO33	F-box protein 33	59660	0.14
chr10_33622034_33622426	0.32	NRP1	neuropilin 1	1080	0.63
chr20_48760619_48760901	0.31	TMEM189-UBE2V1	TMEM189-UBE2V1 readthrough	9414	0.17
chr10_14730521_14730672	0.31	ENSG00000201766	.	25103	0.19
chrX_135230667_135231011	0.31	FHL1	four and a half LIM domains 1	102	0.97
chr7_134330319_134330562	0.30	BPGM	2,3-bisphosphoglycerate mutase	1120	0.61
chr2_216484448_216484719	0.30	AC012462.1		183607	0.03
chr11_106239153_106239583	0.30	RP11-680E19.1		104326	0.08
chr3_75955654_75955867	0.30	ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	86	0.98
chr5_143138706_143138857	0.30	HMHB1	histocompatibility (minor) HB-1	52945	0.16
chr5_141701461_141701673	0.29	SPRY4	sprouty homolog 4 (Drosophila)	2180	0.34
chr8_66629390_66629680	0.29	RP11-707M3.3		2522	0.31
chr16_64425240_64425489	0.29	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	668217	0.0
chr9_21973547_21973827	0.29	CDKN2A	cyclin-dependent kinase inhibitor 2A	1170	0.41
chr8_41165312_41165463	0.29	SFRP1	secreted frizzled-related protein 1	878	0.57
chr10_6763782_6764322	0.29	PRKCQ	protein kinase C, theta	141789	0.05
chr6_170596064_170596215	0.29	DLL1	delta-like 1 (Drosophila)	3422	0.21
chr12_26266071_26266589	0.29	SSPN	sarcospan	8594	0.18
chr3_41244711_41244955	0.29	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	3231	0.41
chr11_2834821_2835116	0.28	KCNQ1-AS1	KCNQ1 antisense RNA 1	47830	0.11
chr6_160457314_160457599	0.28	AIRN	antisense of IGF2R non-protein coding RNA	28760	0.19
chr1_24621564_24621715	0.27	ENSG00000266511	.	15294	0.15
chr12_52301279_52301690	0.27	ACVRL1	activin A receptor type II-like 1	282	0.9
chr7_17720120_17720505	0.27	SNX13	sorting nexin 13	259779	0.02
chr6_28442401_28443147	0.27	ZSCAN23	zinc finger and SCAN domain containing 23	31530	0.13
chr6_69158334_69158485	0.27	ENSG00000266675	.	44922	0.21
chr7_42145445_42145596	0.27	GLI3	GLI family zinc finger 3	121800	0.07
chr1_116472827_116472978	0.26	SLC22A15	solute carrier family 22, member 15	46217	0.16
chr9_9701186_9701337	0.26	ENSG00000265735	.	259201	0.02
chr21_29050610_29050761	0.26	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	711853	0.0
chr3_73085691_73085907	0.26	ENSG00000238959	.	8840	0.16
chr5_134914483_134914805	0.26	CXCL14	chemokine (C-X-C motif) ligand 14	110	0.67
chr16_82049841_82049992	0.26	SDR42E1	short chain dehydrogenase/reductase family 42E, member 1	4823	0.21
chr5_78808053_78808300	0.26	HOMER1	homer homolog 1 (Drosophila)	441	0.86
chr17_15301686_15301923	0.26	ENSG00000239888	.	9897	0.2
chr12_47097195_47097346	0.26	SLC38A4	solute carrier family 38, member 4	65817	0.15
chr15_33130691_33130971	0.25	FMN1	formin 1	49624	0.13
chr6_7544134_7544343	0.25	DSP	desmoplakin	2388	0.28
chr4_181928076_181928259	0.25	ENSG00000251742	.	828094	0.0
chr9_22239273_22239447	0.25	CDKN2B-AS1	CDKN2B antisense RNA 1	125683	0.06
chr17_42214986_42215221	0.25	ENSG00000212446	.	1746	0.18
chr8_57122510_57122859	0.25	PLAG1	pleiomorphic adenoma gene 1	1154	0.41
chr15_59663421_59663716	0.25	FAM81A	family with sequence similarity 81, member A	1324	0.28
chr10_60275835_60276146	0.24	BICC1	bicaudal C homolog 1 (Drosophila)	3090	0.38
chr11_131780111_131780399	0.24	NTM	neurotrimin	642	0.77
chr9_108212044_108212195	0.24	FSD1L	fibronectin type III and SPRY domain containing 1-like	1715	0.48
chr4_78093910_78094061	0.24	CCNG2	cyclin G2	14406	0.22
chr21_36749606_36749887	0.24	RUNX1	runt-related transcription factor 1	328105	0.01
chr1_68214173_68214559	0.24	ENSG00000238778	.	23970	0.19
chr13_27936373_27936791	0.24	ENSG00000252247	.	18699	0.15
chr10_116443956_116444184	0.23	ABLIM1	actin binding LIM protein 1	344	0.91
chr11_85436820_85436971	0.23	SYTL2	synaptotagmin-like 2	616	0.73
chr4_157691847_157691998	0.23	RP11-154F14.2		70589	0.11
chr9_4137636_4137913	0.23	GLIS3	GLIS family zinc finger 3	7419	0.28
chr1_100111779_100111966	0.23	PALMD	palmdelphin	123	0.98
chr10_68587107_68587258	0.23	LRRTM3	leucine rich repeat transmembrane neuronal 3	98582	0.09
chr7_70201396_70202343	0.23	AUTS2	autism susceptibility candidate 2	7744	0.34
chrX_114859841_114860486	0.23	PLS3	plastin 3	13867	0.21
chr9_18472965_18473116	0.22	ADAMTSL1	ADAMTS-like 1	852	0.75
chr1_85247835_85247986	0.22	ENSG00000251899	.	10972	0.25
chr3_112931196_112931871	0.22	BOC	BOC cell adhesion associated, oncogene regulated	124	0.97
chr13_68202936_68203087	0.22	PCDH9	protocadherin 9	398543	0.01
chr14_55569037_55569677	0.22	LGALS3	lectin, galactoside-binding, soluble, 3	21471	0.19
chr5_21818159_21818310	0.22	ENSG00000221615	.	83914	0.11
chr4_149087033_149087184	0.22	RP11-76G10.1		19486	0.29
chr6_138430146_138430297	0.22	PERP	PERP, TP53 apoptosis effector	1573	0.49
chr16_86599945_86600151	0.22	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	809	0.48
chr3_170807489_170807640	0.22	ENSG00000207963	.	16984	0.23
chr3_58983787_58983938	0.21	C3orf67	chromosome 3 open reading frame 67	51855	0.18
chr3_155570793_155570970	0.21	SLC33A1	solute carrier family 33 (acetyl-CoA transporter), member 1	399	0.87
chr11_9587935_9588242	0.21	WEE1	WEE1 G2 checkpoint kinase	7140	0.16
chr12_18841597_18841748	0.21	PLCZ1	phospholipase C, zeta 1	6299	0.25
chr6_140065137_140065288	0.21	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	369455	0.01
chr2_163171316_163171467	0.21	IFIH1	interferon induced with helicase C domain 1	3803	0.25
chr4_89532288_89532605	0.21	HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	5501	0.2
chr21_17909068_17909746	0.21	ENSG00000207638	.	2002	0.33
chr1_229506200_229506351	0.20	ENSG00000252506	.	12600	0.14
chr8_18870397_18870669	0.20	PSD3	pleckstrin and Sec7 domain containing 3	663	0.74
chr15_96886136_96886425	0.20	ENSG00000222651	.	9790	0.16
chr2_184434080_184434231	0.20	ENSG00000238306	.	380008	0.01
chr21_34918443_34918594	0.20	GART	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	2721	0.18
chr13_52218829_52218980	0.20	ENSG00000242893	.	50553	0.11
chr15_101668711_101668940	0.20	RP11-505E24.2		42554	0.16
chr22_45406041_45406799	0.20	PHF21B	PHD finger protein 21B	540	0.81
chr11_127461004_127461155	0.19	ENSG00000223315	.	183333	0.03
chr2_46561817_46561968	0.19	EPAS1	endothelial PAS domain protein 1	37351	0.19
chr10_77648848_77649145	0.19	ENSG00000215921	.	65460	0.13
chr7_28355289_28355446	0.19	CREB5	cAMP responsive element binding protein 5	16427	0.26
chr2_39751073_39751342	0.19	AC007246.3		5391	0.29
chr17_58821066_58821723	0.19	ENSG00000252534	.	5013	0.22
chr3_112803505_112803695	0.19	ENSG00000238593	.	7772	0.2
chr17_65240369_65240671	0.19	RP11-401F2.3		433	0.62
chr1_164532131_164532342	0.19	PBX1	pre-B-cell leukemia homeobox 1	194	0.97
chr6_113734377_113734528	0.19	ENSG00000222677	.	101737	0.08
chr10_69831641_69832005	0.19	HERC4	HECT and RLD domain containing E3 ubiquitin protein ligase 4	2071	0.33
chr7_73246766_73246917	0.19	CLDN4	claudin 4	1648	0.31
chr6_108486676_108487297	0.19	OSTM1	osteopetrosis associated transmembrane protein 1	58	0.78
chr12_56917781_56918152	0.19	RBMS2	RNA binding motif, single stranded interacting protein 2	2183	0.23
chr4_183370400_183371073	0.19	TENM3	teneurin transmembrane protein 3	584	0.84
chr7_32929941_32930760	0.19	KBTBD2	kelch repeat and BTB (POZ) domain containing 2	415	0.87
chr8_59027426_59027596	0.18	FAM110B	family with sequence similarity 110, member B	120398	0.07
chr2_52845575_52845726	0.18	ENSG00000264975	.	84103	0.11
chr1_70672840_70672991	0.18	SRSF11	serine/arginine-rich splicing factor 11	1497	0.3
chr2_163157606_163157781	0.18	IFIH1	interferon induced with helicase C domain 1	17501	0.19
chr5_135470545_135470952	0.18	SMAD5-AS1	SMAD5 antisense RNA 1	169	0.92
chr3_189509857_189510008	0.18	TP63	tumor protein p63	2342	0.39
chr7_17701857_17702150	0.18	SNX13	sorting nexin 13	278088	0.01
chr7_70048822_70048973	0.18	AUTS2	autism susceptibility candidate 2	145228	0.05
chr21_24278413_24278564	0.18	ENSG00000263796	.	225496	0.02
chr2_200446222_200446758	0.18	SATB2	SATB homeobox 2	110501	0.07
chr7_150785302_150785601	0.18	AGAP3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	1297	0.25
chr8_94931050_94931201	0.18	PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	13	0.98
chr13_24782412_24782563	0.18	SPATA13	spermatogenesis associated 13	43345	0.13
chr4_14728626_14728777	0.18	ENSG00000202449	.	36367	0.24
chr14_27067998_27068288	0.18	NOVA1-AS1	NOVA1 antisense RNA 1 (head to head)	525	0.68
chr10_79265125_79265301	0.18	ENSG00000199592	.	81594	0.1
chr11_103677106_103677422	0.17	ENSG00000264200	.	43370	0.2
chr3_159484310_159484461	0.17	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	1493	0.34
chr6_16737749_16737900	0.17	RP1-151F17.1		23545	0.22
chr5_87780535_87780686	0.17	TMEM161B-AS1	TMEM161B antisense RNA 1	58098	0.14
chr16_54968513_54968925	0.17	IRX5	iroquois homeobox 5	2735	0.43
chr8_10568187_10568338	0.17	CTD-2135J3.3		18562	0.12
chr12_104613330_104613526	0.17	TXNRD1	thioredoxin reductase 1	3869	0.26
chr3_124421533_124421684	0.17	ENSG00000263775	.	5725	0.16
chr2_37798390_37798541	0.17	AC006369.2		28814	0.21
chr4_148657265_148657705	0.17	ARHGAP10	Rho GTPase activating protein 10	4271	0.21
chr3_159483781_159484285	0.17	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	1141	0.44
chr10_16992831_16993197	0.17	CUBN	cubilin (intrinsic factor-cobalamin receptor)	33180	0.22
chr15_33154166_33154394	0.17	FMN1	formin 1	26175	0.19
chr3_185446261_185446412	0.17	C3orf65	chromosome 3 open reading frame 65	15256	0.21
chr9_111249319_111249470	0.17	ENSG00000222512	.	128185	0.06
chr22_36232810_36232961	0.17	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	3380	0.35
chr7_80542898_80543049	0.17	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	5526	0.35
chr5_79542586_79542846	0.17	ENSG00000239159	.	7308	0.19
chr5_109671354_109671505	0.17	ENSG00000221436	.	178187	0.03
chr1_149378983_149379172	0.16	FCGR1C	Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene	9720	0.13
chr20_19966352_19966503	0.16	NAA20	N(alpha)-acetyltransferase 20, NatB catalytic subunit	31333	0.18
chr18_66505598_66505749	0.16	CCDC102B	coiled-coil domain containing 102B	1672	0.41
chr2_233453880_233454031	0.16	AC073254.1		2577	0.17
chr14_88738980_88739131	0.16	KCNK10	potassium channel, subfamily K, member 10	1800	0.48
chr5_92918170_92918321	0.16	NR2F1	nuclear receptor subfamily 2, group F, member 1	798	0.54
chr19_56332953_56333104	0.16	NLRP11	NLR family, pyrin domain containing 11	3425	0.16
chrX_107680802_107681081	0.16	COL4A6	collagen, type IV, alpha 6	615	0.74
chr15_101069679_101069830	0.16	CERS3	ceramide synthase 3	14722	0.15
chr11_12696722_12697409	0.16	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	15	0.99
chr1_68686585_68686736	0.16	WLS	wntless Wnt ligand secretion mediator	10710	0.23
chr18_59665868_59666178	0.16	RNF152	ring finger protein 152	104559	0.07
chr1_203648008_203648159	0.16	ATP2B4	ATPase, Ca++ transporting, plasma membrane 4	3854	0.27
chr17_35851593_35851869	0.16	DUSP14	dual specificity phosphatase 14	161	0.96
chr1_191327786_191327937	0.16	RGS18	regulator of G-protein signaling 18	799726	0.0
chr6_114181963_114182196	0.16	MARCKS	myristoylated alanine-rich protein kinase C substrate	3538	0.24
chr6_125420988_125421372	0.16	TPD52L1	tumor protein D52-like 1	19015	0.24
chr10_5005306_5005493	0.16	AKR1C1	aldo-keto reductase family 1, member C1	46	0.92
chr3_58038318_58038519	0.16	FLNB	filamin B, beta	25638	0.22
chr2_205529494_205529645	0.16	PARD3B	par-3 family cell polarity regulator beta	118846	0.07
chr1_178027513_178027706	0.16	RASAL2	RAS protein activator like 2	35255	0.22
chr15_74880905_74881056	0.16	CLK3	CDC-like kinase 3	19733	0.14
chr15_96897591_96898313	0.15	AC087477.1	Uncharacterized protein	6535	0.18
chr10_5045552_5046386	0.15	AKR1C2	aldo-keto reductase family 1, member C2	83	0.93
chr17_69531749_69531900	0.15	ENSG00000222563	.	224515	0.02
chr9_71790192_71790670	0.15	TJP2	tight junction protein 2	1221	0.59
chr17_63550102_63550306	0.15	AXIN2	axin 2	4643	0.32
chr5_123149834_123150053	0.15	CSNK1G3	casein kinase 1, gamma 3	225824	0.02
chr3_197121898_197122049	0.15	ENSG00000238491	.	55551	0.12
chr20_30309971_30310242	0.15	BCL2L1	BCL2-like 1	245	0.84
chr4_152331570_152331721	0.15	FAM160A1	family with sequence similarity 160, member A1	1141	0.61
chr18_53067170_53067321	0.15	TCF4	transcription factor 4	1321	0.53
chr1_55183020_55183171	0.15	TTC4	tetratricopeptide repeat domain 4	1600	0.36
chr3_98605225_98605614	0.15	DCBLD2	discoidin, CUB and LCCL domain containing 2	14596	0.17
chr4_44656889_44657040	0.15	YIPF7	Yip1 domain family, member 7	3306	0.24
chr2_179144221_179144372	0.15	OSBPL6	oxysterol binding protein-like 6	5358	0.27
chr1_220527416_220527567	0.15	AC096644.1	Uncharacterized protein	80532	0.09
chr10_74600201_74600352	0.15	OIT3	oncoprotein induced transcript 3	53063	0.12
chr3_87036535_87037613	0.15	VGLL3	vestigial like 3 (Drosophila)	2778	0.42
chr5_124820548_124820891	0.15	ENSG00000222107	.	133895	0.06

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.1	0.3	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.4	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.3	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1	0.2	GO:0071504	cellular response to heparin(GO:0071504)
0.1	0.2	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1	0.4	GO:0060347	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.1	0.1	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.1	0.2	GO:0051182	coenzyme transport(GO:0051182)
0.1	0.2	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.1	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0072141	mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0	0.0	GO:0003160	endocardium development(GO:0003157) endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214)
0.0	0.1	GO:0033087	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.1	GO:0045605	negative regulation of epidermal cell differentiation(GO:0045605)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.3	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.0	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.2	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.0	0.2	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.2	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.2	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.1	GO:0071681	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.1	GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus(GO:0002866)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.2	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0010662	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.2	GO:0048821	erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.2	GO:0050812	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.1	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.0	GO:0051014	actin filament severing(GO:0051014)
0.0	0.3	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.0	GO:0072194	kidney smooth muscle tissue development(GO:0072194)
0.0	0.0	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.2	GO:0008038	neuron recognition(GO:0008038)
0.0	0.2	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.0	GO:0060900	embryonic camera-type eye formation(GO:0060900)
0.0	0.1	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.1	GO:0060736	prostate gland growth(GO:0060736)
0.0	0.0	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.1	GO:0097354	protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0	0.1	GO:0030299	intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0	0.1	GO:0002068	glandular epithelial cell development(GO:0002068)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.0	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.0	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.0	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.0	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.5	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.0	0.2	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.3	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.2	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.2	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.0	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.0	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.0	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0032589	neuron projection membrane(GO:0032589)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.3	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.2	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.3	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.3	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.2	GO:0004083	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.2	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.2	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.2	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.3	GO:0045296	cadherin binding(GO:0045296)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.0	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.2	GO:0051184	cofactor transporter activity(GO:0051184)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.0	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.0	GO:0070324	thyroid hormone binding(GO:0070324)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.4	PID NECTIN PATHWAY	Nectin adhesion pathway
0.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.4	NABA COLLAGENS	Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SIGNALING BY FGFR IN DISEASE	Genes involved in Signaling by FGFR in disease
0.0	0.0	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.9	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.4	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.2	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	0.3	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network