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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for POU6F1

Z-value: 1.32

Motif logo

Transcription factors associated with POU6F1

Gene Symbol	Gene ID	Gene Info
POU6F1 Ensembl NCBI GeneCards UniProt	ENSG00000184271.11	POU6F1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
POU6F1	chr12_51611354_51611505	48	0.962858	-0.54	1.3e-01	Click!
POU6F1	chr12_51611544_51611860	225	0.898800	-0.47	2.0e-01	Click!
POU6F1	chr12_51610572_51610723	830	0.510628	-0.46	2.1e-01	Click!
POU6F1	chr12_51610343_51610494	1059	0.412881	0.37	3.3e-01	Click!
POU6F1	chr12_51610880_51611170	452	0.747794	0.14	7.1e-01	Click!

Activity of the POU6F1 motif across conditions

Conditions sorted by the z-value of the POU6F1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_160766445_160766727	1.13	LY9	lymphocyte antigen 9	609	0.72
chr6_90790442_90790643	1.03	ENSG00000222078	.	79317	0.1
chrX_11778976_11779311	0.98	MSL3	male-specific lethal 3 homolog (Drosophila)	1396	0.58
chr19_6481304_6482171	0.96	DENND1C	DENN/MADD domain containing 1C	27	0.95
chr5_169720489_169720914	0.93	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	4530	0.26
chr2_233926827_233927087	0.91	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	1768	0.35
chr1_100820231_100820573	0.85	CDC14A	cell division cycle 14A	1897	0.33
chrX_78400540_78401325	0.85	GPR174	G protein-coupled receptor 174	25537	0.27
chr4_40201423_40201705	0.83	RHOH	ras homolog family member H	400	0.87
chrX_41779133_41779284	0.81	ENSG00000251807	.	606	0.77
chr12_54891959_54892179	0.80	NCKAP1L	NCK-associated protein 1-like	499	0.73
chr12_9912315_9912520	0.79	CD69	CD69 molecule	1080	0.47
chr10_73529493_73529671	0.76	C10orf54	chromosome 10 open reading frame 54	3673	0.23
chr5_130413183_130413334	0.75	HINT1	histidine triad nucleotide binding protein 1	85062	0.1
chr14_22977314_22977663	0.74	TRAJ15	T cell receptor alpha joining 15	21092	0.09
chrX_56590218_56591666	0.74	UBQLN2	ubiquilin 2	916	0.74
chr2_106392161_106392312	0.74	NCK2	NCK adaptor protein 2	30048	0.23
chr15_86235334_86235485	0.73	RP11-815J21.1		8931	0.12
chr6_35271134_35271290	0.72	DEF6	differentially expressed in FDCP 6 homolog (mouse)	5583	0.2
chr19_48747420_48747628	0.72	CARD8	caspase recruitment domain family, member 8	3204	0.16
chr14_55799126_55799413	0.71	RP11-665C16.5		6950	0.25
chr7_38386000_38386394	0.71	AMPH	amphiphysin	116516	0.06
chr1_9477600_9477751	0.70	ENSG00000252956	.	20162	0.21
chr2_158299843_158300108	0.70	CYTIP	cytohesin 1 interacting protein	679	0.68
chr2_136876136_136876323	0.69	CXCR4	chemokine (C-X-C motif) receptor 4	494	0.87
chr6_112078365_112078719	0.69	FYN	FYN oncogene related to SRC, FGR, YES	1775	0.47
chr11_102192518_102192994	0.69	BIRC3	baculoviral IAP repeat containing 3	3196	0.22
chr6_139458457_139458631	0.68	HECA	headcase homolog (Drosophila)	2295	0.39
chr2_102973306_102973457	0.68	IL18R1	interleukin 18 receptor 1	992	0.54
chr1_89664962_89665153	0.68	GBP4	guanylate binding protein 4	442	0.83
chr6_119398487_119399078	0.67	FAM184A	family with sequence similarity 184, member A	755	0.67
chr4_40209794_40209945	0.67	RHOH	ras homolog family member H	7905	0.22
chr7_38381792_38381992	0.66	AMPH	amphiphysin	120821	0.06
chr2_231193737_231193888	0.65	SP140L	SP140 nuclear body protein-like	1827	0.43
chr20_39769733_39769905	0.64	RP1-1J6.2		3176	0.25
chr7_38399403_38399654	0.63	AMPH	amphiphysin	103185	0.08
chr7_142344805_142344957	0.63	MTRNR2L6	MT-RNR2-like 6	29223	0.21
chr17_37933702_37934037	0.62	IKZF3	IKAROS family zinc finger 3 (Aiolos)	609	0.66
chr5_39201497_39202174	0.62	FYB	FYN binding protein	1294	0.59
chr10_30818195_30818576	0.61	ENSG00000239744	.	26448	0.21
chr2_182174133_182174359	0.60	ENSG00000266705	.	3867	0.36
chr1_160678018_160678169	0.58	CD48	CD48 molecule	3500	0.2
chr15_61013382_61013533	0.58	ENSG00000212625	.	15511	0.2
chr10_173487_173638	0.58	ZMYND11	zinc finger, MYND-type containing 11	6843	0.24
chr3_63954232_63954647	0.58	ATXN7	ataxin 7	1019	0.48
chr10_11208288_11208755	0.57	CELF2	CUGBP, Elav-like family member 2	1030	0.57
chr15_34620156_34620427	0.57	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	8754	0.11
chr17_80084198_80084349	0.57	CCDC57	coiled-coil domain containing 57	2159	0.16
chr3_112692076_112692299	0.56	CD200R1	CD200 receptor 1	1572	0.33
chr1_154303209_154303360	0.56	ATP8B2	ATPase, aminophospholipid transporter, class I, type 8B, member 2	2009	0.18
chr7_38393634_38393798	0.56	AMPH	amphiphysin	108997	0.07
chr11_128343021_128343263	0.55	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	32147	0.21
chr1_207509360_207509653	0.55	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	14370	0.25
chr1_6087488_6087778	0.55	KCNAB2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	276	0.91
chr12_739807_740337	0.55	RP11-218M22.1		15	0.97
chr12_50908828_50909000	0.54	DIP2B	DIP2 disco-interacting protein 2 homolog B (Drosophila)	10024	0.23
chr2_101558018_101558169	0.54	NPAS2	neuronal PAS domain protein 2	16469	0.19
chr2_133917317_133917468	0.54	AC011755.1	HCG2006742; Protein LOC100996685	42815	0.19
chr8_8727283_8727434	0.53	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	23797	0.18
chr11_2322790_2323148	0.53	C11orf21	chromosome 11 open reading frame 21	174	0.62
chr3_4536182_4536507	0.53	ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	1110	0.44
chr3_66444263_66444450	0.53	ENSG00000241587	.	70077	0.12
chr7_38343163_38343314	0.53	STARD3NL	STARD3 N-terminal like	125241	0.06
chr3_114017077_114017228	0.52	TIGIT	T cell immunoreceptor with Ig and ITIM domains	3318	0.23
chr14_99723235_99723386	0.52	AL109767.1		5975	0.23
chr7_150146102_150146542	0.52	GIMAP8	GTPase, IMAP family member 8	1396	0.39
chr6_114716123_114716274	0.52	RP3-399L15.3		30578	0.21
chr16_28172650_28172801	0.52	XPO6	exportin 6	8497	0.18
chr8_8655354_8655505	0.51	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	95726	0.07
chr9_130735579_130735768	0.51	FAM102A	family with sequence similarity 102, member A	7119	0.11
chr5_156617150_156617301	0.50	ITK	IL2-inducible T-cell kinase	9388	0.13
chrY_7144223_7144374	0.50	PRKY	protein kinase, Y-linked, pseudogene	1944	0.4
chr21_43640506_43640792	0.50	ENSG00000223262	.	634	0.47
chr7_144509813_144510191	0.50	TPK1	thiamin pyrophosphokinase 1	23144	0.23
chr12_92528336_92528532	0.50	C12orf79	chromosome 12 open reading frame 79	2363	0.27
chr14_61805647_61805798	0.49	PRKCH	protein kinase C, eta	5238	0.22
chr3_108549304_108549455	0.49	TRAT1	T cell receptor associated transmembrane adaptor 1	7760	0.27
chr4_150608043_150608194	0.49	ENSG00000202331	.	220594	0.02
chr2_219599622_219599773	0.49	TTLL4	tubulin tyrosine ligase-like family, member 4	2600	0.21
chr7_130610833_130610984	0.49	ENSG00000226380	.	48610	0.15
chr1_150542961_150543112	0.48	ENSG00000264584	.	1291	0.23
chr20_54993887_54994066	0.48	CASS4	Cas scaffolding protein family member 4	6659	0.14
chr7_38402576_38402839	0.48	AMPH	amphiphysin	100006	0.08
chr14_22984428_22984696	0.48	TRAJ15	T cell receptor alpha joining 15	14018	0.1
chr18_72662806_72662957	0.47	ZADH2	zinc binding alcohol dehydrogenase domain containing 2	254587	0.02
chr3_152002190_152002341	0.47	MBNL1-AS1	MBNL1 antisense RNA 1	14921	0.21
chrX_78407976_78408214	0.46	GPR174	G protein-coupled receptor 174	18374	0.29
chr18_2982488_2982849	0.46	LPIN2	lipin 2	203	0.93
chr8_66843424_66843611	0.46	PDE7A	phosphodiesterase 7A	89330	0.09
chr12_94805998_94806149	0.46	CCDC41	coiled-coil domain containing 41	47649	0.14
chr5_4638073_4638224	0.46	ENSG00000223007	.	488011	0.01
chr13_48795647_48795882	0.46	ITM2B	integral membrane protein 2B	11530	0.26
chr14_69821359_69821510	0.45	ERH	enhancer of rudimentary homolog (Drosophila)	43582	0.15
chr22_20905629_20905785	0.45	MED15	mediator complex subunit 15	130	0.95
chr8_13346130_13346281	0.45	DLC1	deleted in liver cancer 1	10545	0.24
chr17_63225008_63225159	0.45	RGS9	regulator of G-protein signaling 9	91491	0.08
chr6_109801994_109802145	0.45	ZBTB24	zinc finger and BTB domain containing 24	2371	0.18
chr18_72873277_72873679	0.45	ZADH2	zinc binding alcohol dehydrogenase domain containing 2	43990	0.18
chr1_206732541_206732911	0.44	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	2233	0.27
chr7_12601305_12601456	0.44	SCIN	scinderin	8932	0.23
chr6_90791046_90791197	0.44	ENSG00000222078	.	79896	0.1
chr6_22249892_22250043	0.44	RP3-404K8.2		10686	0.27
chr11_128589269_128589524	0.44	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	23478	0.17
chr7_151622563_151622783	0.44	ENSG00000222941	.	9261	0.14
chr1_158902534_158902685	0.43	PYHIN1	pyrin and HIN domain family, member 1	1251	0.51
chr9_100749769_100749920	0.43	RP11-535C21.3		94	0.96
chr6_112076140_112076291	0.43	FYN	FYN oncogene related to SRC, FGR, YES	4102	0.32
chr17_79258803_79259366	0.43	SLC38A10	solute carrier family 38, member 10	3020	0.17
chr1_39025698_39025869	0.43	ENSG00000200796	.	163452	0.04
chr3_18483093_18483271	0.43	SATB1	SATB homeobox 1	2917	0.27
chr6_45983691_45983842	0.43	CLIC5	chloride intracellular channel 5	180	0.95
chr7_50267269_50267784	0.42	IKZF1	IKAROS family zinc finger 1 (Ikaros)	76798	0.1
chr1_12445934_12446085	0.42	VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	23915	0.22
chr17_76767868_76768019	0.42	CYTH1	cytohesin 1	10411	0.19
chr6_143867244_143867395	0.42	PHACTR2	phosphatase and actin regulator 2	9337	0.16
chrX_106954029_106954352	0.42	TSC22D3	TSC22 domain family, member 3	5441	0.26
chr10_54571770_54571921	0.42	MBL2	mannose-binding lectin (protein C) 2, soluble	40385	0.17
chr5_67577391_67577649	0.42	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	1385	0.58
chr12_9908788_9909139	0.42	CD69	CD69 molecule	4534	0.18
chr12_14924776_14925101	0.42	HIST4H4	histone cluster 4, H4	873	0.43
chr6_149805124_149805364	0.41	ZC3H12D	zinc finger CCCH-type containing 12D	882	0.55
chr9_77635535_77635794	0.41	RP11-197P3.5		4712	0.19
chr6_45463753_45463944	0.41	RUNX2	runt-related transcription factor 2	73626	0.11
chr10_111769664_111769909	0.41	ADD3	adducin 3 (gamma)	2064	0.33
chr17_35285773_35285924	0.41	RP11-445F12.1		8073	0.14
chr3_37997723_37997874	0.41	CTDSPL	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	8272	0.16
chr2_214004488_214004639	0.41	IKZF2	IKAROS family zinc finger 2 (Helios)	8790	0.3
chrX_12969564_12969715	0.41	TMSB4X	thymosin beta 4, X-linked	23588	0.18
chr4_36243817_36244102	0.41	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1602	0.35
chr3_56949638_56949992	0.41	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	684	0.75
chr12_77165442_77165593	0.40	ZDHHC17	zinc finger, DHHC-type containing 17	7164	0.3
chr6_27106968_27108062	0.40	HIST1H4I	histone cluster 1, H4i	439	0.71
chr12_72523140_72523291	0.40	RP11-89M22.3		72058	0.12
chrX_48773434_48773585	0.40	PIM2	pim-2 oncogene	497	0.64
chr2_238603556_238603753	0.39	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	2672	0.32
chr2_44154306_44154579	0.39	LRPPRC	leucine-rich pentatricopeptide repeat containing	28019	0.17
chr6_118985728_118985996	0.39	CEP85L	centrosomal protein 85kDa-like	12179	0.29
chr12_19705618_19705769	0.39	AEBP2	AE binding protein 2	52630	0.17
chr14_38558504_38558837	0.39	CTD-2058B24.2		1693	0.48
chr9_125662893_125663901	0.39	RC3H2	ring finger and CCCH-type domains 2	3008	0.16
chr2_75067589_75067763	0.39	HK2	hexokinase 2	5379	0.28
chr1_100823462_100823613	0.39	CDC14A	cell division cycle 14A	5032	0.21
chr7_133906611_133906762	0.38	AC008154.4		62566	0.13
chr5_81074467_81075538	0.38	SSBP2	single-stranded DNA binding protein 2	27930	0.25
chr11_118178183_118178334	0.38	CD3E	CD3e molecule, epsilon (CD3-TCR complex)	2644	0.19
chr3_111043169_111043480	0.38	CD96	CD96 molecule	31758	0.24
chr7_76822766_76822966	0.38	FGL2	fibrinogen-like 2	6277	0.24
chr14_69281480_69282477	0.37	ZFP36L1	ZFP36 ring finger protein-like 1	18788	0.19
chr4_99525122_99525342	0.37	TSPAN5	tetraspanin 5	53554	0.14
chr2_11859670_11859821	0.37	AC012456.3		4603	0.15
chr5_20958214_20958365	0.37	CDH18	cadherin 18, type 2	382307	0.01
chr11_3856061_3856212	0.37	RHOG	ras homolog family member G	2961	0.14
chr9_101881575_101881851	0.37	TGFBR1	transforming growth factor, beta receptor 1	8344	0.21
chr6_139352039_139352190	0.37	ABRACL	ABRA C-terminal like	2135	0.38
chr13_46752006_46752233	0.37	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	4340	0.19
chr2_72438706_72438857	0.36	CYP26B1	cytochrome P450, family 26, subfamily B, polypeptide 1	63614	0.16
chr11_34212282_34212433	0.36	ENSG00000201867	.	1636	0.49
chr9_100667248_100667478	0.36	C9orf156	chromosome 9 open reading frame 156	7390	0.17
chr22_39238770_39238921	0.36	NPTXR	neuronal pentraxin receptor	1142	0.39
chrX_78620829_78620980	0.36	ITM2A	integral membrane protein 2A	1952	0.51
chr1_158902219_158902370	0.36	PYHIN1	pyrin and HIN domain family, member 1	936	0.62
chr4_90220151_90220996	0.35	GPRIN3	GPRIN family member 3	8588	0.31
chr3_111261315_111261845	0.35	CD96	CD96 molecule	583	0.82
chr7_151048885_151049126	0.35	NUB1	negative regulator of ubiquitin-like proteins 1	6574	0.16
chr17_75178097_75178354	0.35	SEC14L1	SEC14-like 1 (S. cerevisiae)	1106	0.55
chr7_37382144_37382404	0.35	ELMO1	engulfment and cell motility 1	93	0.97
chr14_24641513_24641917	0.35	REC8	REC8 meiotic recombination protein	105	0.89
chr3_114801119_114801270	0.35	ZBTB20	zinc finger and BTB domain containing 20	10972	0.32
chr13_24777878_24778029	0.35	ENSG00000252695	.	41398	0.13
chr14_39593348_39593499	0.35	GEMIN2	gem (nuclear organelle) associated protein 2	9442	0.18
chr13_41556565_41556847	0.35	ELF1	E74-like factor 1 (ets domain transcription factor)	288	0.92
chr1_103470741_103470892	0.35	COL11A1	collagen, type XI, alpha 1	77599	0.13
chr21_35885755_35885906	0.34	KCNE1	potassium voltage-gated channel, Isk-related family, member 1	1257	0.46
chr2_87813494_87813645	0.34	RP11-1399P15.1		36016	0.22
chr5_100116536_100116687	0.34	ENSG00000221263	.	35658	0.2
chr18_56282753_56282991	0.34	ALPK2	alpha-kinase 2	13317	0.15
chr1_215739347_215739498	0.34	KCTD3	potassium channel tetramerization domain containing 3	1313	0.59
chr1_237204411_237204562	0.34	RYR2	ryanodine receptor 2 (cardiac)	1019	0.63
chr1_169679248_169679951	0.34	SELL	selectin L	1240	0.48
chr2_101944298_101944469	0.34	ENSG00000264857	.	18471	0.16
chr14_22993528_22993679	0.34	TRAJ15	T cell receptor alpha joining 15	4977	0.12
chr7_65723704_65723855	0.34	TPST1	tyrosylprotein sulfotransferase 1	37188	0.16
chrX_135738768_135738919	0.34	CD40LG	CD40 ligand	8457	0.18
chrX_124428887_124429038	0.34	ENSG00000263886	.	7337	0.34
chr3_107844575_107844939	0.34	CD47	CD47 molecule	34885	0.22
chr1_209946189_209946340	0.34	TRAF3IP3	TRAF3 interacting protein 3	4304	0.16
chr7_56124875_56125026	0.34	ENSG00000206603	.	1892	0.19
chr7_130643743_130643906	0.34	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	25044	0.22
chr8_131204031_131204182	0.34	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	10998	0.24
chr9_74921921_74922072	0.34	ENSG00000252428	.	7242	0.27
chr12_12867727_12867916	0.34	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	2237	0.23
chr12_105076421_105076798	0.33	ENSG00000264295	.	91198	0.08
chr2_220113848_220114166	0.33	STK16	serine/threonine kinase 16	3389	0.09
chr5_130849992_130850161	0.33	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	6226	0.32
chr14_22182172_22182323	0.33	OR4E2	olfactory receptor, family 4, subfamily E, member 2	48950	0.13
chr3_74049848_74049999	0.33	ENSG00000212585	.	165280	0.04
chr10_3919669_3920010	0.33	KLF6	Kruppel-like factor 6	92366	0.09
chr3_170984257_170984408	0.33	TNIK	TRAF2 and NCK interacting kinase	40832	0.2
chr8_1920933_1921192	0.33	KBTBD11	kelch repeat and BTB (POZ) domain containing 11	982	0.66
chr10_70852755_70852906	0.33	SRGN	serglycin	4956	0.21

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0030011	maintenance of cell polarity(GO:0030011)
0.1	0.4	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.4	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.6	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.1	0.1	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.1	0.2	GO:0014808	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.1	0.4	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.1	0.4	GO:0002093	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.1	0.3	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.3	GO:0051712	positive regulation of killing of cells of other organism(GO:0051712)
0.1	0.3	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.1	0.2	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.1	0.2	GO:0051136	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.1	0.3	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.1	0.2	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.3	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.1	0.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.1	0.3	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.1	0.2	GO:0010508	positive regulation of autophagy(GO:0010508)
0.1	0.2	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.6	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.1	0.6	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.3	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	1.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.5	GO:0007141	male meiosis I(GO:0007141)
0.0	0.2	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.4	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.0	GO:0046949	fatty-acyl-CoA biosynthetic process(GO:0046949)
0.0	0.3	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.2	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.2	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	2.3	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.1	GO:0090009	primitive streak formation(GO:0090009)
0.0	0.1	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.4	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.2	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.3	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.1	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.2	GO:0042167	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.1	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.2	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.3	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.1	GO:0031342	negative regulation of leukocyte mediated cytotoxicity(GO:0001911) negative regulation of cell killing(GO:0031342)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.2	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0002335	mature B cell differentiation involved in immune response(GO:0002313) mature B cell differentiation(GO:0002335)
0.0	0.2	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.0	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.2	GO:0042953	lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:2000400	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.2	GO:0032148	activation of protein kinase B activity(GO:0032148)
0.0	0.0	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.3	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.0	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.0	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.0	GO:0045606	positive regulation of epidermal cell differentiation(GO:0045606)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0014805	smooth muscle adaptation(GO:0014805)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.2	GO:0045576	mast cell activation(GO:0045576)
0.0	0.0	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.1	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.0	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	1.1	GO:0016064	immunoglobulin mediated immune response(GO:0016064) B cell mediated immunity(GO:0019724)
0.0	0.0	GO:0046885	regulation of hormone biosynthetic process(GO:0046885)
0.0	0.1	GO:1903513	endoplasmic reticulum to cytosol transport(GO:1903513)
0.0	0.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.0	GO:0052306	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308) positive regulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052555) positive regulation by symbiont of host immune response(GO:0052556)
0.0	0.0	GO:0060413	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)
0.0	0.0	GO:0031442	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0061687	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0006012	galactose metabolic process(GO:0006012)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.0	GO:0003057	regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0	0.1	GO:0032418	lysosome localization(GO:0032418)
0.0	0.0	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.0	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0043330	response to exogenous dsRNA(GO:0043330)
0.0	0.0	GO:0048664	neuron fate determination(GO:0048664)
0.0	0.1	GO:0015919	peroxisomal membrane transport(GO:0015919)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.3	GO:0045762	positive regulation of cyclase activity(GO:0031281) positive regulation of adenylate cyclase activity(GO:0045762)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.0	GO:0097502	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.1	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.1	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0007140	male meiosis(GO:0007140)
0.0	0.0	GO:2000909	regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.0	0.0	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.4	GO:0019432	triglyceride biosynthetic process(GO:0019432)
0.0	0.0	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.0	GO:0060457	negative regulation of digestive system process(GO:0060457)
0.0	0.0	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.2	GO:0007632	visual behavior(GO:0007632)
0.0	0.0	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.0	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.0	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.0	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0	0.1	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0001958	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.3	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.0	0.0	GO:0045359	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.1	GO:1901998	antibiotic transport(GO:0042891) toxin transport(GO:1901998)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0052200	response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
0.0	0.1	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.0	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0072487	MSL complex(GO:0072487)
0.1	0.4	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.5	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.1	0.3	GO:0000800	lateral element(GO:0000800)
0.1	0.4	GO:0034451	centriolar satellite(GO:0034451)
0.1	0.2	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1	0.4	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.4	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.2	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.2	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.2	GO:0001950	obsolete plasma membrane enriched fraction(GO:0001950)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.5	GO:0032420	stereocilium(GO:0032420)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.3	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.3	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.2	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.5	GO:0016592	mediator complex(GO:0016592)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.0	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.2	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.0	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.0	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.1	GO:0030897	HOPS complex(GO:0030897)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.0	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.0	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.2	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	0.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.0	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.5	GO:0000794	condensed nuclear chromosome(GO:0000794)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	0.7	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	0.5	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.3	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.9	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	0.3	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.1	0.3	GO:0043422	protein kinase B binding(GO:0043422)
0.1	0.2	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.2	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.5	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.2	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.3	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.2	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.3	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.8	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.2	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.0	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.2	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.7	GO:0030295	protein kinase activator activity(GO:0030295)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.3	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.7	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	0.2	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0036041	long-chain fatty acid binding(GO:0036041)
0.0	0.0	GO:0004396	hexokinase activity(GO:0004396)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.2	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.5	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.2	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.3	GO:0017127	cholesterol transporter activity(GO:0017127)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.3	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	1.0	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.4	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.6	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.3	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.1	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0019209	kinase activator activity(GO:0019209)
0.0	0.0	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.2	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.0	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0004663	Rab geranylgeranyltransferase activity(GO:0004663)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0004437	obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0	1.2	GO:0017124	SH3 domain binding(GO:0017124)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.0	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.0	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0046965	retinoid X receptor binding(GO:0046965)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.0	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.0	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.0	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.0	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.4	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.3	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.0	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.0	GO:0008420	CTD phosphatase activity(GO:0008420)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.4	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.5	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	1.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	0.6	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.7	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.6	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.9	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.4	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.4	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.2	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.2	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.1	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	0.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.2	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.0	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	1.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	1.0	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	0.5	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.5	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.7	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.4	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.4	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0	1.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.4	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.6	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.2	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	1.6	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.2	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.2	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.3	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	1.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.2	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.2	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.3	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.8	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.1	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.2	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.3	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.1	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0	0.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.1	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	0.1	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.3	REACTOME AMYLOIDS	Genes involved in Amyloids