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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for PRRX1_ALX4_PHOX2A

Z-value: 0.51

Motif logo

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Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol Gene ID Gene Info
PRRX1
ENSG00000116132.7 paired related homeobox 1
ALX4
ENSG00000052850.5 ALX homeobox 4
PHOX2A
ENSG00000165462.5 paired like homeobox 2A

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr11_44266782_44266933ALX4648590.128077-0.742.3e-02Click!
chr11_44327749_44327900ALX438920.3484170.655.6e-02Click!
chr11_44326896_44327745ALX443960.3366410.646.3e-02Click!
chr11_44383183_44383459ALX4516050.169738-0.627.6e-02Click!
chr11_44332044_44332208ALX44100.9105510.571.1e-01Click!
chr11_71951481_71951632PHOX2A6800.533839-0.571.1e-01Click!
chr11_71955390_71955541PHOX2A2450.869181-0.137.3e-01Click!
chr11_71951210_71951424PHOX2A9190.405100-0.058.9e-01Click!
chr11_71950539_71951040PHOX2A14470.247984-0.059.0e-01Click!
chr1_170637427_170637622PRRX144460.329492-0.891.3e-03Click!
chr1_170588762_170588958PRRX1434150.173502-0.881.6e-03Click!
chr1_170637207_170637377PRRX142140.334181-0.881.7e-03Click!
chr1_170647677_170647828PRRX1146740.277214-0.863.2e-03Click!
chr1_170638728_170639131PRRX158510.310948-0.835.1e-03Click!

Activity of the PRRX1_ALX4_PHOX2A motif across conditions

Conditions sorted by the z-value of the PRRX1_ALX4_PHOX2A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_100722020_100722171 0.91 RP1-121G13.2
152899
 0.04
chr14_99707128_99707406 0.55 AL109767.1
22018
 0.2
chr1_192546230_192546423 0.54 RGS1
 regulator of G-protein signaling 1
 1423
 0.45
chr1_117301810_117301961 0.48 CD2
 CD2 molecule
 4796
 0.25
chr12_118796178_118796667 0.48 TAOK3
 TAO kinase 3
 488
 0.85
chr13_74806186_74806399 0.43 ENSG00000206617
 .
 57059
 0.16
chr14_22947593_22947744 0.43 TRAJ60
 T cell receptor alpha joining 60 (pseudogene)
 2372
 0.15
chr4_46115537_46115688 0.42 GABRG1
 gamma-aminobutyric acid (GABA) A receptor, gamma 1
 10486
 0.3
chr4_103448739_103448914 0.42 NFKB1
 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
 24294
 0.18
chr5_96294037_96294231 0.42 LNPEP
 leucyl/cystinyl aminopeptidase
 21
 0.98
chr3_63954232_63954647 0.40 ATXN7
 ataxin 7
 1019
 0.48
chr5_40685237_40685679 0.40 PTGER4
 prostaglandin E receptor 4 (subtype EP4)
 5858
 0.22
chr16_81748402_81748687 0.40 PLCG2
 phospholipase C, gamma 2 (phosphatidylinositol-specific)
 24158
 0.24
chr3_151961363_151961565 0.39 MBNL1
 muscleblind-like splicing regulator 1
 24365
 0.2
chr12_26967694_26967845 0.39 ITPR2
 inositol 1,4,5-trisphosphate receptor, type 2
 17945
 0.24
chr11_104838069_104839428 0.39 CASP4
 caspase 4, apoptosis-related cysteine peptidase
 1345
 0.45
chr7_50415328_50415483 0.38 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 48160
 0.16
chr10_82259532_82259683 0.38 RP11-137H2.4
36091
 0.14
chr10_8101958_8102217 0.37 GATA3
 GATA binding protein 3
 5318
 0.35
chr4_143488164_143488362 0.37 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 6441
 0.35
chr4_40201182_40201333 0.37 RHOH
 ras homolog family member H
 707
 0.72
chr1_198612556_198613143 0.37 PTPRC
 protein tyrosine phosphatase, receptor type, C
 4557
 0.28
chr13_67288038_67288189 0.36 ENSG00000238500
 .
 83205
 0.1
chr15_61963769_61963920 0.36 ENSG00000266349
 .
 72296
 0.13
chr3_18477156_18477307 0.35 SATB1
 SATB homeobox 1
 486
 0.83
chr6_82470488_82470639 0.35 ENSG00000206886
 .
 3178
 0.26
chr2_161993456_161993757 0.35 TANK
 TRAF family member-associated NFKB activator
 140
 0.97
chr4_101941691_101941842 0.35 EMCN-IT1
 EMCN intronic transcript 1 (non-protein coding)
 206329
 0.02
chr10_3989446_3989597 0.35 KLF6
 Kruppel-like factor 6
 162048
 0.04
chr11_14669296_14669647 0.34 PDE3B
 phosphodiesterase 3B, cGMP-inhibited
 4094
 0.26
chr2_165752618_165752769 0.34 ENSG00000223318
 .
 406
 0.84
chr3_43329409_43329595 0.34 SNRK
 SNF related kinase
 1424
 0.43
chr12_46611391_46611598 0.34 SLC38A1
 solute carrier family 38, member 1
 49990
 0.18
chr1_111212990_111213454 0.34 KCNA3
 potassium voltage-gated channel, shaker-related subfamily, member 3
 4433
 0.21
chr4_40210765_40210916 0.34 RHOH
 ras homolog family member H
 8876
 0.22
chr2_225809390_225809894 0.33 DOCK10
 dedicator of cytokinesis 10
 2140
 0.45
chrX_35788537_35788688 0.33 MAGEB16
 melanoma antigen family B, 16
 27847
 0.25
chr7_33078848_33079779 0.33 NT5C3A
 5'-nucleotidase, cytosolic IIIA
 1208
 0.42
chr20_43597121_43597440 0.33 STK4
 serine/threonine kinase 4
 2113
 0.25
chr10_30745504_30745655 0.32 MAP3K8
 mitogen-activated protein kinase kinase kinase 8
 17828
 0.21
chr5_44684027_44684178 0.32 ENSG00000263556
 .
 32190
 0.23
chr6_149641931_149642082 0.32 TAB2
 TGF-beta activated kinase 1/MAP3K7 binding protein 2
 182
 0.95
chr8_102506754_102506905 0.32 GRHL2
 grainyhead-like 2 (Drosophila)
 1843
 0.34
chr10_3514525_3515428 0.32 RP11-184A2.3
278283
 0.01
chr3_138524893_138525044 0.32 PIK3CB
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
 28626
 0.22
chr13_99957828_99957979 0.32 GPR183
 G protein-coupled receptor 183
 1756
 0.38
chr6_25040218_25040369 0.32 RP3-425P12.5
1774
 0.29
chr1_102637571_102637722 0.31 OLFM3
 olfactomedin 3
 175060
 0.04
chr3_45010992_45011143 0.31 ZDHHC3
 zinc finger, DHHC-type containing 3
 6591
 0.16
chr17_38018344_38018495 0.31 IKZF3
 IKAROS family zinc finger 3 (Aiolos)
 1960
 0.26
chr3_151922152_151922513 0.31 MBNL1
 muscleblind-like splicing regulator 1
 63497
 0.12
chr5_138942780_138942931 0.31 UBE2D2
 ubiquitin-conjugating enzyme E2D 2
 1241
 0.44
chr6_128580481_128581088 0.31 PTPRK
 protein tyrosine phosphatase, receptor type, K
 62542
 0.14
chr14_99726709_99727240 0.31 AL109767.1
2311
 0.33
chr16_81030456_81031156 0.31 CMC2
 C-x(9)-C motif containing 2
 1458
 0.31
chr11_6765821_6765972 0.30 GVINP1
 GTPase, very large interferon inducible pseudogene 1
 22785
 0.11
chr7_129620661_129620812 0.30 ENSG00000263557
 .
 4851
 0.14
chr6_112078365_112078719 0.30 FYN
 FYN oncogene related to SRC, FGR, YES
 1775
 0.47
chr7_110171741_110171892 0.30 AC073326.3
194065
 0.03
chr4_124343109_124343622 0.29 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 22242
 0.29
chr12_105035462_105035613 0.29 ENSG00000264295
 .
 50126
 0.15
chr21_32563083_32563234 0.29 TIAM1
 T-cell lymphoma invasion and metastasis 1
 60619
 0.14
chr12_92532725_92532888 0.29 C12orf79
 chromosome 12 open reading frame 79
 2009
 0.29
chr2_69029555_69029831 0.29 ARHGAP25
 Rho GTPase activating protein 25
 4670
 0.25
chr1_118989201_118989352 0.29 ENSG00000222209
 .
 182164
 0.03
chr2_109239146_109239415 0.29 LIMS1
 LIM and senescent cell antigen-like domains 1
 1558
 0.46
chr4_154411300_154411567 0.28 KIAA0922
 KIAA0922
 23932
 0.22
chr5_77901409_77901560 0.28 LHFPL2
 lipoma HMGIC fusion partner-like 2
 43164
 0.21
chr13_75900164_75900519 0.28 TBC1D4
 TBC1 domain family, member 4
 15326
 0.24
chr16_89449371_89449542 0.28 RP1-168P16.2
29516
 0.11
chr8_8727017_8727210 0.28 MFHAS1
 malignant fibrous histiocytoma amplified sequence 1
 24042
 0.18
chr1_211526219_211526370 0.28 TRAF5
 TNF receptor-associated factor 5
 6588
 0.27
chr7_7298568_7298818 0.28 C1GALT1
 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
 24742
 0.22
chr5_84331121_84331272 0.28 ENSG00000215953
 .
 492756
 0.01
chr13_84126063_84126363 0.28 ENSG00000222791
 .
 253911
 0.02
chr6_35568962_35570321 0.28 ENSG00000212579
 .
 49954
 0.1
chr3_128892694_128892845 0.28 CNBP
 CCHC-type zinc finger, nucleic acid binding protein
 9973
 0.13
chr1_84610455_84610717 0.28 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
 632
 0.82
chr14_102285064_102285215 0.27 CTD-2017C7.2
8481
 0.15
chr3_112693608_112694254 0.27 CD200R1
 CD200 receptor 1
 6
 0.97
chr15_27495001_27495152 0.27 GABRG3
 gamma-aminobutyric acid (GABA) A receptor, gamma 3
 21613
 0.2
chr2_197029492_197029688 0.27 STK17B
 serine/threonine kinase 17b
 6134
 0.21
chr8_66751055_66751459 0.27 PDE7A
 phosphodiesterase 7A
 274
 0.95
chr10_14690079_14690726 0.27 RP11-7C6.1
4339
 0.23
chr11_89271457_89271608 0.27 NOX4
 NADPH oxidase 4
 40177
 0.2
chr5_148726675_148726837 0.27 GRPEL2
 GrpE-like 2, mitochondrial (E. coli)
 1691
 0.25
chr1_29253817_29254129 0.27 EPB41
 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
 12882
 0.18
chrX_128914916_128915218 0.27 SASH3
 SAM and SH3 domain containing 3
 1107
 0.52
chr12_111868224_111868441 0.27 SH2B3
 SH2B adaptor protein 3
 4334
 0.21
chr10_55152331_55152482 0.27 ENSG00000252161
 .
 65551
 0.15
chr5_73730259_73730491 0.27 ENSG00000244326
 .
 116564
 0.06
chr3_169385047_169385198 0.27 MECOM
 MDS1 and EVI1 complex locus
 3864
 0.21
chr7_104907675_104908170 0.27 SRPK2
 SRSF protein kinase 2
 1540
 0.45
chr6_138192975_138193775 0.27 RP11-356I2.4
4005
 0.25
chr10_116285471_116285868 0.27 ABLIM1
 actin binding LIM protein 1
 925
 0.69
chr9_134603422_134603972 0.26 ENSG00000240853
 .
 2843
 0.28
chr6_24932242_24932425 0.26 FAM65B
 family with sequence similarity 65, member B
 3855
 0.28
chr13_113218720_113218871 0.26 TUBGCP3
 tubulin, gamma complex associated protein 3
 23644
 0.23
chr1_167483926_167484083 0.26 CD247
 CD247 molecule
 3771
 0.25
chr1_111744675_111744826 0.26 CHI3L2
 chitinase 3-like 2
 1357
 0.27
chr21_39875929_39876080 0.26 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 5597
 0.34
chrX_102942579_102943009 0.26 MORF4L2
 mortality factor 4 like 2
 172
 0.82
chr3_40518130_40518400 0.26 ZNF619
 zinc finger protein 619
 339
 0.84
chr12_57077777_57078354 0.26 PTGES3
 prostaglandin E synthase 3 (cytosolic)
 3881
 0.14
chr5_88667405_88667690 0.26 MEF2C-AS1
 MEF2C antisense RNA 1
 47077
 0.21
chr18_57572017_57572168 0.26 PMAIP1
 phorbol-12-myristate-13-acetate-induced protein 1
 4844
 0.29
chr1_32395224_32395375 0.26 PTP4A2
 protein tyrosine phosphatase type IVA, member 2
 8087
 0.18
chr20_62270981_62271132 0.26 CTD-3184A7.4
12453
 0.09
chr3_31575511_31576107 0.26 STT3B
 STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
 1527
 0.55
chr14_22977314_22977663 0.25 TRAJ15
 T cell receptor alpha joining 15
 21092
 0.09
chr6_54713491_54713642 0.25 FAM83B
 family with sequence similarity 83, member B
 1997
 0.36
chr2_162100666_162100830 0.25 AC009299.2
6925
 0.21
chr2_103035121_103035519 0.25 IL18RAP
 interleukin 18 receptor accessory protein
 171
 0.93
chr3_189932576_189932727 0.25 ENSG00000212489
 .
 49339
 0.13
chr6_106547996_106548204 0.25 RP1-134E15.3
85
 0.96
chr12_81614843_81614994 0.25 ENSG00000265227
 .
 62751
 0.12
chr5_23013128_23013556 0.25 CDH12
 cadherin 12, type 2 (N-cadherin 2)
 159611
 0.04
chr9_22667582_22667733 0.25 DMRTA1
 DMRT-like family A1
 220817
 0.02
chr1_56527776_56527927 0.25 PIGQP1
 phosphatidylinositol glycan anchor biosynthesis, class Q pseudogene 1
 122898
 0.06
chr20_35575234_35575857 0.25 SAMHD1
 SAM domain and HD domain 1
 4566
 0.25
chr1_198652510_198652661 0.25 RP11-553K8.5
16395
 0.24
chr11_96075064_96076300 0.25 MAML2
 mastermind-like 2 (Drosophila)
 662
 0.57
chr8_131273225_131273376 0.25 ASAP1
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
 14012
 0.28
chr4_111437212_111437424 0.24 RP11-380D23.1
3343
 0.3
chr2_158292578_158292753 0.24 CYTIP
 cytohesin 1 interacting protein
 3261
 0.28
chr1_114489881_114490100 0.24 HIPK1
 homeodomain interacting protein kinase 1
 3777
 0.17
chr3_63956535_63956875 0.24 ATXN7
 ataxin 7
 3285
 0.2
chr15_65592052_65592203 0.24 ENSG00000199568
 .
 3738
 0.15
chr18_830449_831025 0.24 YES1
 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
 18190
 0.15
chr2_204801338_204802214 0.24 ICOS
 inducible T-cell co-stimulator
 273
 0.95
chr18_67713592_67713743 0.24 RTTN
 rotatin
 25713
 0.25
chr7_104659627_104659839 0.24 KMT2E
 lysine (K)-specific methyltransferase 2E
 4825
 0.18
chr5_67580506_67580669 0.24 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 3609
 0.36
chrX_135861825_135862156 0.24 ARHGEF6
 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
 2257
 0.28
chr21_25801249_25801648 0.24 ENSG00000232512
 .
 671997
 0.0
chr7_7287223_7287567 0.24 C1GALT1
 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
 13444
 0.24
chr12_40076724_40077004 0.24 C12orf40
 chromosome 12 open reading frame 40
 56879
 0.14
chr1_12445934_12446085 0.24 VPS13D
 vacuolar protein sorting 13 homolog D (S. cerevisiae)
 23915
 0.22
chr5_37198039_37198190 0.24 C5orf42
 chromosome 5 open reading frame 42
 15610
 0.24
chr17_29647712_29648226 0.24 EVI2A
 ecotropic viral integration site 2A
 81
 0.95
chr11_63570647_63570807 0.24 ENSG00000264519
 .
 5184
 0.17
chr2_191929470_191929872 0.24 ENSG00000231858
 .
 43419
 0.12
chr3_114913699_114913850 0.23 ZBTB20
 zinc finger and BTB domain containing 20
 47656
 0.2
chr14_100547439_100547590 0.23 CTD-2376I20.1
6299
 0.15
chr16_86530318_86530469 0.23 FOXF1
 forkhead box F1
 13740
 0.21
chr7_124982277_124982428 0.23 POT1-AS1
 POT1 antisense RNA 1
 349290
 0.01
chr3_187456856_187457007 0.23 BCL6
 B-cell CLL/lymphoma 6
 1199
 0.52
chr6_10522420_10522571 0.23 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
 911
 0.58
chr13_68238536_68238687 0.23 PCDH9
 protocadherin 9
 434143
 0.01
chr1_160614457_160614608 0.23 SLAMF1
 signaling lymphocytic activation molecule family member 1
 2279
 0.26
chr2_197023764_197023994 0.23 STK17B
 serine/threonine kinase 17b
 2508
 0.29
chr21_33764461_33765016 0.23 URB1
 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
 597
 0.45
chr10_77531854_77532472 0.23 C10orf11
 chromosome 10 open reading frame 11
 10356
 0.22
chr16_53469656_53469844 0.23 RBL2
 retinoblastoma-like 2 (p130)
 219
 0.92
chr12_42492275_42492426 0.23 ENSG00000222884
 .
 18787
 0.22
chr6_19609542_19609693 0.23 ENSG00000200957
 .
 33143
 0.24
chr2_158299843_158300108 0.23 CYTIP
 cytohesin 1 interacting protein
 679
 0.68
chr17_64341332_64341625 0.23 ENSG00000244044
 .
 18669
 0.19
chr16_22383801_22383959 0.23 CDR2
 cerebellar degeneration-related protein 2, 62kDa
 2058
 0.22
chr7_133454612_133454763 0.23 EXOC4
 exocyst complex component 4
 160535
 0.04
chr5_118607055_118607314 0.23 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 2735
 0.27
chr17_40781310_40781461 0.23 FAM134C
 family with sequence similarity 134, member C
 18744
 0.08
chr11_82461800_82462168 0.23 FAM181B
 family with sequence similarity 181, member B
 17078
 0.25
chr5_39186752_39186903 0.22 FYB
 FYN binding protein
 16302
 0.26
chr7_37381672_37381823 0.22 ELMO1
 engulfment and cell motility 1
 620
 0.76
chr6_10409161_10409312 0.22 TFAP2A-AS1
 TFAP2A antisense RNA 1
 337
 0.8
chr14_22977019_22977170 0.22 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 20923
 0.09
chr4_154418637_154418870 0.22 KIAA0922
 KIAA0922
 31252
 0.2
chr9_92444951_92445102 0.22 GADD45G
 growth arrest and DNA-damage-inducible, gamma
 225073
 0.02
chr1_198651611_198651863 0.22 RP11-553K8.5
15547
 0.24
chr2_158295494_158296053 0.22 CYTIP
 cytohesin 1 interacting protein
 153
 0.96
chr10_17548651_17548924 0.22 ST8SIA6
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
 52458
 0.13
chr3_111258341_111258694 0.22 CD96
 CD96 molecule
 2339
 0.39
chr10_22282945_22283096 0.22 DNAJC1
 DnaJ (Hsp40) homolog, subfamily C, member 1
 9308
 0.27
chr1_234747019_234747378 0.22 IRF2BP2
 interferon regulatory factor 2 binding protein 2
 1927
 0.32
chr3_136677766_136677917 0.22 IL20RB
 interleukin 20 receptor beta
 990
 0.56
chr4_76051776_76051927 0.21 RP11-44F21.2
91817
 0.09
chr5_96000350_96000501 0.21 CAST
 calpastatin
 1668
 0.37
chr3_152005414_152005684 0.21 MBNL1
 muscleblind-like splicing regulator 1
 11645
 0.21
chr20_52205540_52206428 0.21 ZNF217
 zinc finger protein 217
 4394
 0.22
chr1_89737700_89738180 0.21 GBP5
 guanylate binding protein 5
 547
 0.77
chr15_71389366_71389517 0.21 THSD4
 thrombospondin, type I, domain containing 4
 150
 0.97
chr2_27273737_27274028 0.21 AGBL5
 ATP/GTP binding protein-like 5
 6
 0.9
chr20_57232821_57232972 0.21 STX16
 syntaxin 16
 5833
 0.18
chr12_9912992_9913534 0.21 CD69
 CD69 molecule
 234
 0.92
chrX_13103844_13104411 0.21 FAM9C
 family with sequence similarity 9, member C
 41326
 0.19
chr9_82427530_82428232 0.21 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 106200
 0.08
chr15_93427252_93427403 0.21 CHD2
 chromodomain helicase DNA binding protein 2
 801
 0.63
chr10_17701952_17702103 0.21 STAM
 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
 15763
 0.14
chr6_143264540_143264691 0.21 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 1723
 0.46
chr5_49965541_49965784 0.21 PARP8
 poly (ADP-ribose) polymerase family, member 8
 2271
 0.47
chr14_61814123_61814302 0.21 PRKCH
 protein kinase C, eta
 397
 0.87
chr1_241714712_241714945 0.21 KMO
 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
 17107
 0.2
chr19_13841985_13842408 0.21 CCDC130
 coiled-coil domain containing 130
 378
 0.8
chr6_119212181_119212332 0.21 ASF1A
 anti-silencing function 1A histone chaperone
 3128
 0.28
chr12_132671196_132671356 0.21 GALNT9
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
 19061
 0.17
chr3_195276037_195276188 0.21 AC091633.3
2693
 0.22
chr14_91863541_91863979 0.21 CCDC88C
 coiled-coil domain containing 88C
 19930
 0.21
chr5_56794860_56795362 0.21 ACTBL2
 actin, beta-like 2
 16475
 0.22
chr13_99992298_99992449 0.21 ENSG00000207719
 .
 16012
 0.19

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.3 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1 0.2 GO:0042494 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1 0.2 GO:0010761 fibroblast migration(GO:0010761)
0.1 0.4 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1 0.2 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.1 0.3 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.1 0.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 0.2 GO:0060789 hair follicle placode formation(GO:0060789)
0.1 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 0.2 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 0.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.2 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.1 GO:1900121 regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.2 GO:0035608 protein deglutamylation(GO:0035608)
0.0 0.1 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.2 GO:1904035 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.1 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.4 GO:0006911 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.0 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.2 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.2 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 0.0 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.2 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.0 0.1 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.3 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0032632 interleukin-3 production(GO:0032632)
0.0 0.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.3 GO:0050856 regulation of T cell receptor signaling pathway(GO:0050856)
0.0 0.4 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.1 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.2 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0046719 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.1 GO:0010523 negative regulation of calcium ion transport into cytosol(GO:0010523)
0.0 0.1 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.6 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0044380 protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.0 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.0 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.1 GO:0071635 negative regulation of transforming growth factor beta production(GO:0071635)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.5 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.0 0.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.1 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0009215 purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0 0.0 GO:0060916 mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0 0.0 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.2 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.1 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0072133 kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.0 GO:0090311 regulation of protein deacetylation(GO:0090311) positive regulation of protein deacetylation(GO:0090312)
0.0 0.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0048935 peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.0 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0 0.0 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.0 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.0 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0 0.0 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.0 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.1 GO:0055064 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.0 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0 0.3 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.1 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.1 GO:0098926 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.2 GO:0000018 regulation of DNA recombination(GO:0000018)
0.0 0.1 GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.1 GO:0051828 entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0 0.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.2 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.0 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.0 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.1 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.0 0.1 GO:0010165 response to X-ray(GO:0010165)
0.0 0.4 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.1 GO:0036465 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.0 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.0 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.3 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.0 GO:0051665 membrane raft localization(GO:0051665)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.0 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0 0.0 GO:0090205 positive regulation of cholesterol metabolic process(GO:0090205)
0.0 0.0 GO:0044321 cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.1 GO:0031529 ruffle organization(GO:0031529)
0.0 0.0 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.0 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.2 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0042827 platelet dense granule(GO:0042827)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.2 GO:0016580 Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0 0.1 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.0 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.0 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0001950 obsolete plasma membrane enriched fraction(GO:0001950)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.0 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.0 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.0 GO:1903561 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.4 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.2 GO:0001846 opsonin binding(GO:0001846)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.1 GO:0070513 death domain binding(GO:0070513)
0.0 0.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.6 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.0 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0004516 nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0 0.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.0 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.0 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.3 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.0 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.0 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.2 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
0.0 0.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.0 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0051766 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.1 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.0 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.0 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.0 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.0 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.4 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.3 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.3 PID EPO PATHWAY EPO signaling pathway
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.5 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.3 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.7 PID FOXO PATHWAY FoxO family signaling
0.0 0.1 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.4 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.1 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.1 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.1 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.6 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.9 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.0 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.2 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.1 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.0 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.1 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.1 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis