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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PRRX1_ALX4_PHOX2A

Z-value: 0.51

Motif logo

Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol	Gene ID	Gene Info
PRRX1 Ensembl NCBI GeneCards UniProt	ENSG00000116132.7	PRRX1
ALX4 Ensembl NCBI GeneCards UniProt	ENSG00000052850.5	ALX4
PHOX2A Ensembl NCBI GeneCards UniProt	ENSG00000165462.5	PHOX2A

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ALX4	chr11_44266782_44266933	64859	0.128077	-0.74	2.3e-02	Click!
ALX4	chr11_44327749_44327900	3892	0.348417	0.65	5.6e-02	Click!
ALX4	chr11_44326896_44327745	4396	0.336641	0.64	6.3e-02	Click!
ALX4	chr11_44383183_44383459	51605	0.169738	-0.62	7.6e-02	Click!
ALX4	chr11_44332044_44332208	410	0.910551	0.57	1.1e-01	Click!
PHOX2A	chr11_71951481_71951632	680	0.533839	-0.57	1.1e-01	Click!
PHOX2A	chr11_71955390_71955541	245	0.869181	-0.13	7.3e-01	Click!
PHOX2A	chr11_71951210_71951424	919	0.405100	-0.05	8.9e-01	Click!
PHOX2A	chr11_71950539_71951040	1447	0.247984	-0.05	9.0e-01	Click!
PRRX1	chr1_170637427_170637622	4446	0.329492	-0.89	1.3e-03	Click!
PRRX1	chr1_170588762_170588958	43415	0.173502	-0.88	1.6e-03	Click!
PRRX1	chr1_170637207_170637377	4214	0.334181	-0.88	1.7e-03	Click!
PRRX1	chr1_170647677_170647828	14674	0.277214	-0.86	3.2e-03	Click!
PRRX1	chr1_170638728_170639131	5851	0.310948	-0.83	5.1e-03	Click!

Activity of the PRRX1_ALX4_PHOX2A motif across conditions

Conditions sorted by the z-value of the PRRX1_ALX4_PHOX2A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_100722020_100722171	0.91	RP1-121G13.2		152899	0.04
chr14_99707128_99707406	0.55	AL109767.1		22018	0.2
chr1_192546230_192546423	0.54	RGS1	regulator of G-protein signaling 1	1423	0.45
chr1_117301810_117301961	0.48	CD2	CD2 molecule	4796	0.25
chr12_118796178_118796667	0.48	TAOK3	TAO kinase 3	488	0.85
chr13_74806186_74806399	0.43	ENSG00000206617	.	57059	0.16
chr14_22947593_22947744	0.43	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	2372	0.15
chr4_46115537_46115688	0.42	GABRG1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	10486	0.3
chr4_103448739_103448914	0.42	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	24294	0.18
chr5_96294037_96294231	0.42	LNPEP	leucyl/cystinyl aminopeptidase	21	0.98
chr3_63954232_63954647	0.40	ATXN7	ataxin 7	1019	0.48
chr5_40685237_40685679	0.40	PTGER4	prostaglandin E receptor 4 (subtype EP4)	5858	0.22
chr16_81748402_81748687	0.40	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	24158	0.24
chr3_151961363_151961565	0.39	MBNL1	muscleblind-like splicing regulator 1	24365	0.2
chr12_26967694_26967845	0.39	ITPR2	inositol 1,4,5-trisphosphate receptor, type 2	17945	0.24
chr11_104838069_104839428	0.39	CASP4	caspase 4, apoptosis-related cysteine peptidase	1345	0.45
chr7_50415328_50415483	0.38	IKZF1	IKAROS family zinc finger 1 (Ikaros)	48160	0.16
chr10_82259532_82259683	0.38	RP11-137H2.4		36091	0.14
chr10_8101958_8102217	0.37	GATA3	GATA binding protein 3	5318	0.35
chr4_143488164_143488362	0.37	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	6441	0.35
chr4_40201182_40201333	0.37	RHOH	ras homolog family member H	707	0.72
chr1_198612556_198613143	0.37	PTPRC	protein tyrosine phosphatase, receptor type, C	4557	0.28
chr13_67288038_67288189	0.36	ENSG00000238500	.	83205	0.1
chr15_61963769_61963920	0.36	ENSG00000266349	.	72296	0.13
chr3_18477156_18477307	0.35	SATB1	SATB homeobox 1	486	0.83
chr6_82470488_82470639	0.35	ENSG00000206886	.	3178	0.26
chr2_161993456_161993757	0.35	TANK	TRAF family member-associated NFKB activator	140	0.97
chr4_101941691_101941842	0.35	EMCN-IT1	EMCN intronic transcript 1 (non-protein coding)	206329	0.02
chr10_3989446_3989597	0.35	KLF6	Kruppel-like factor 6	162048	0.04
chr11_14669296_14669647	0.34	PDE3B	phosphodiesterase 3B, cGMP-inhibited	4094	0.26
chr2_165752618_165752769	0.34	ENSG00000223318	.	406	0.84
chr3_43329409_43329595	0.34	SNRK	SNF related kinase	1424	0.43
chr12_46611391_46611598	0.34	SLC38A1	solute carrier family 38, member 1	49990	0.18
chr1_111212990_111213454	0.34	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	4433	0.21
chr4_40210765_40210916	0.34	RHOH	ras homolog family member H	8876	0.22
chr2_225809390_225809894	0.33	DOCK10	dedicator of cytokinesis 10	2140	0.45
chrX_35788537_35788688	0.33	MAGEB16	melanoma antigen family B, 16	27847	0.25
chr7_33078848_33079779	0.33	NT5C3A	5'-nucleotidase, cytosolic IIIA	1208	0.42
chr20_43597121_43597440	0.33	STK4	serine/threonine kinase 4	2113	0.25
chr10_30745504_30745655	0.32	MAP3K8	mitogen-activated protein kinase kinase kinase 8	17828	0.21
chr5_44684027_44684178	0.32	ENSG00000263556	.	32190	0.23
chr6_149641931_149642082	0.32	TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	182	0.95
chr8_102506754_102506905	0.32	GRHL2	grainyhead-like 2 (Drosophila)	1843	0.34
chr10_3514525_3515428	0.32	RP11-184A2.3		278283	0.01
chr3_138524893_138525044	0.32	PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	28626	0.22
chr13_99957828_99957979	0.32	GPR183	G protein-coupled receptor 183	1756	0.38
chr6_25040218_25040369	0.32	RP3-425P12.5		1774	0.29
chr1_102637571_102637722	0.31	OLFM3	olfactomedin 3	175060	0.04
chr3_45010992_45011143	0.31	ZDHHC3	zinc finger, DHHC-type containing 3	6591	0.16
chr17_38018344_38018495	0.31	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1960	0.26
chr3_151922152_151922513	0.31	MBNL1	muscleblind-like splicing regulator 1	63497	0.12
chr5_138942780_138942931	0.31	UBE2D2	ubiquitin-conjugating enzyme E2D 2	1241	0.44
chr6_128580481_128581088	0.31	PTPRK	protein tyrosine phosphatase, receptor type, K	62542	0.14
chr14_99726709_99727240	0.31	AL109767.1		2311	0.33
chr16_81030456_81031156	0.31	CMC2	C-x(9)-C motif containing 2	1458	0.31
chr11_6765821_6765972	0.30	GVINP1	GTPase, very large interferon inducible pseudogene 1	22785	0.11
chr7_129620661_129620812	0.30	ENSG00000263557	.	4851	0.14
chr6_112078365_112078719	0.30	FYN	FYN oncogene related to SRC, FGR, YES	1775	0.47
chr7_110171741_110171892	0.30	AC073326.3		194065	0.03
chr4_124343109_124343622	0.29	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	22242	0.29
chr12_105035462_105035613	0.29	ENSG00000264295	.	50126	0.15
chr21_32563083_32563234	0.29	TIAM1	T-cell lymphoma invasion and metastasis 1	60619	0.14
chr12_92532725_92532888	0.29	C12orf79	chromosome 12 open reading frame 79	2009	0.29
chr2_69029555_69029831	0.29	ARHGAP25	Rho GTPase activating protein 25	4670	0.25
chr1_118989201_118989352	0.29	ENSG00000222209	.	182164	0.03
chr2_109239146_109239415	0.29	LIMS1	LIM and senescent cell antigen-like domains 1	1558	0.46
chr4_154411300_154411567	0.28	KIAA0922	KIAA0922	23932	0.22
chr5_77901409_77901560	0.28	LHFPL2	lipoma HMGIC fusion partner-like 2	43164	0.21
chr13_75900164_75900519	0.28	TBC1D4	TBC1 domain family, member 4	15326	0.24
chr16_89449371_89449542	0.28	RP1-168P16.2		29516	0.11
chr8_8727017_8727210	0.28	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	24042	0.18
chr1_211526219_211526370	0.28	TRAF5	TNF receptor-associated factor 5	6588	0.27
chr7_7298568_7298818	0.28	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	24742	0.22
chr5_84331121_84331272	0.28	ENSG00000215953	.	492756	0.01
chr13_84126063_84126363	0.28	ENSG00000222791	.	253911	0.02
chr6_35568962_35570321	0.28	ENSG00000212579	.	49954	0.1
chr3_128892694_128892845	0.28	CNBP	CCHC-type zinc finger, nucleic acid binding protein	9973	0.13
chr1_84610455_84610717	0.28	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	632	0.82
chr14_102285064_102285215	0.27	CTD-2017C7.2		8481	0.15
chr3_112693608_112694254	0.27	CD200R1	CD200 receptor 1	6	0.97
chr15_27495001_27495152	0.27	GABRG3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	21613	0.2
chr2_197029492_197029688	0.27	STK17B	serine/threonine kinase 17b	6134	0.21
chr8_66751055_66751459	0.27	PDE7A	phosphodiesterase 7A	274	0.95
chr10_14690079_14690726	0.27	RP11-7C6.1		4339	0.23
chr11_89271457_89271608	0.27	NOX4	NADPH oxidase 4	40177	0.2
chr5_148726675_148726837	0.27	GRPEL2	GrpE-like 2, mitochondrial (E. coli)	1691	0.25
chr1_29253817_29254129	0.27	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12882	0.18
chrX_128914916_128915218	0.27	SASH3	SAM and SH3 domain containing 3	1107	0.52
chr12_111868224_111868441	0.27	SH2B3	SH2B adaptor protein 3	4334	0.21
chr10_55152331_55152482	0.27	ENSG00000252161	.	65551	0.15
chr5_73730259_73730491	0.27	ENSG00000244326	.	116564	0.06
chr3_169385047_169385198	0.27	MECOM	MDS1 and EVI1 complex locus	3864	0.21
chr7_104907675_104908170	0.27	SRPK2	SRSF protein kinase 2	1540	0.45
chr6_138192975_138193775	0.27	RP11-356I2.4		4005	0.25
chr10_116285471_116285868	0.27	ABLIM1	actin binding LIM protein 1	925	0.69
chr9_134603422_134603972	0.26	ENSG00000240853	.	2843	0.28
chr6_24932242_24932425	0.26	FAM65B	family with sequence similarity 65, member B	3855	0.28
chr13_113218720_113218871	0.26	TUBGCP3	tubulin, gamma complex associated protein 3	23644	0.23
chr1_167483926_167484083	0.26	CD247	CD247 molecule	3771	0.25
chr1_111744675_111744826	0.26	CHI3L2	chitinase 3-like 2	1357	0.27
chr21_39875929_39876080	0.26	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	5597	0.34
chrX_102942579_102943009	0.26	MORF4L2	mortality factor 4 like 2	172	0.82
chr3_40518130_40518400	0.26	ZNF619	zinc finger protein 619	339	0.84
chr12_57077777_57078354	0.26	PTGES3	prostaglandin E synthase 3 (cytosolic)	3881	0.14
chr5_88667405_88667690	0.26	MEF2C-AS1	MEF2C antisense RNA 1	47077	0.21
chr18_57572017_57572168	0.26	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	4844	0.29
chr1_32395224_32395375	0.26	PTP4A2	protein tyrosine phosphatase type IVA, member 2	8087	0.18
chr20_62270981_62271132	0.26	CTD-3184A7.4		12453	0.09
chr3_31575511_31576107	0.26	STT3B	STT3B, subunit of the oligosaccharyltransferase complex (catalytic)	1527	0.55
chr14_22977314_22977663	0.25	TRAJ15	T cell receptor alpha joining 15	21092	0.09
chr6_54713491_54713642	0.25	FAM83B	family with sequence similarity 83, member B	1997	0.36
chr2_162100666_162100830	0.25	AC009299.2		6925	0.21
chr2_103035121_103035519	0.25	IL18RAP	interleukin 18 receptor accessory protein	171	0.93
chr3_189932576_189932727	0.25	ENSG00000212489	.	49339	0.13
chr6_106547996_106548204	0.25	RP1-134E15.3		85	0.96
chr12_81614843_81614994	0.25	ENSG00000265227	.	62751	0.12
chr5_23013128_23013556	0.25	CDH12	cadherin 12, type 2 (N-cadherin 2)	159611	0.04
chr9_22667582_22667733	0.25	DMRTA1	DMRT-like family A1	220817	0.02
chr1_56527776_56527927	0.25	PIGQP1	phosphatidylinositol glycan anchor biosynthesis, class Q pseudogene 1	122898	0.06
chr20_35575234_35575857	0.25	SAMHD1	SAM domain and HD domain 1	4566	0.25
chr1_198652510_198652661	0.25	RP11-553K8.5		16395	0.24
chr11_96075064_96076300	0.25	MAML2	mastermind-like 2 (Drosophila)	662	0.57
chr8_131273225_131273376	0.25	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	14012	0.28
chr4_111437212_111437424	0.24	RP11-380D23.1		3343	0.3
chr2_158292578_158292753	0.24	CYTIP	cytohesin 1 interacting protein	3261	0.28
chr1_114489881_114490100	0.24	HIPK1	homeodomain interacting protein kinase 1	3777	0.17
chr3_63956535_63956875	0.24	ATXN7	ataxin 7	3285	0.2
chr15_65592052_65592203	0.24	ENSG00000199568	.	3738	0.15
chr18_830449_831025	0.24	YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	18190	0.15
chr2_204801338_204802214	0.24	ICOS	inducible T-cell co-stimulator	273	0.95
chr18_67713592_67713743	0.24	RTTN	rotatin	25713	0.25
chr7_104659627_104659839	0.24	KMT2E	lysine (K)-specific methyltransferase 2E	4825	0.18
chr5_67580506_67580669	0.24	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	3609	0.36
chrX_135861825_135862156	0.24	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	2257	0.28
chr21_25801249_25801648	0.24	ENSG00000232512	.	671997	0.0
chr7_7287223_7287567	0.24	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	13444	0.24
chr12_40076724_40077004	0.24	C12orf40	chromosome 12 open reading frame 40	56879	0.14
chr1_12445934_12446085	0.24	VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	23915	0.22
chr5_37198039_37198190	0.24	C5orf42	chromosome 5 open reading frame 42	15610	0.24
chr17_29647712_29648226	0.24	EVI2A	ecotropic viral integration site 2A	81	0.95
chr11_63570647_63570807	0.24	ENSG00000264519	.	5184	0.17
chr2_191929470_191929872	0.24	ENSG00000231858	.	43419	0.12
chr3_114913699_114913850	0.23	ZBTB20	zinc finger and BTB domain containing 20	47656	0.2
chr14_100547439_100547590	0.23	CTD-2376I20.1		6299	0.15
chr16_86530318_86530469	0.23	FOXF1	forkhead box F1	13740	0.21
chr7_124982277_124982428	0.23	POT1-AS1	POT1 antisense RNA 1	349290	0.01
chr3_187456856_187457007	0.23	BCL6	B-cell CLL/lymphoma 6	1199	0.52
chr6_10522420_10522571	0.23	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	911	0.58
chr13_68238536_68238687	0.23	PCDH9	protocadherin 9	434143	0.01
chr1_160614457_160614608	0.23	SLAMF1	signaling lymphocytic activation molecule family member 1	2279	0.26
chr2_197023764_197023994	0.23	STK17B	serine/threonine kinase 17b	2508	0.29
chr21_33764461_33765016	0.23	URB1	URB1 ribosome biogenesis 1 homolog (S. cerevisiae)	597	0.45
chr10_77531854_77532472	0.23	C10orf11	chromosome 10 open reading frame 11	10356	0.22
chr16_53469656_53469844	0.23	RBL2	retinoblastoma-like 2 (p130)	219	0.92
chr12_42492275_42492426	0.23	ENSG00000222884	.	18787	0.22
chr6_19609542_19609693	0.23	ENSG00000200957	.	33143	0.24
chr2_158299843_158300108	0.23	CYTIP	cytohesin 1 interacting protein	679	0.68
chr17_64341332_64341625	0.23	ENSG00000244044	.	18669	0.19
chr16_22383801_22383959	0.23	CDR2	cerebellar degeneration-related protein 2, 62kDa	2058	0.22
chr7_133454612_133454763	0.23	EXOC4	exocyst complex component 4	160535	0.04
chr5_118607055_118607314	0.23	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	2735	0.27
chr17_40781310_40781461	0.23	FAM134C	family with sequence similarity 134, member C	18744	0.08
chr11_82461800_82462168	0.23	FAM181B	family with sequence similarity 181, member B	17078	0.25
chr5_39186752_39186903	0.22	FYB	FYN binding protein	16302	0.26
chr7_37381672_37381823	0.22	ELMO1	engulfment and cell motility 1	620	0.76
chr6_10409161_10409312	0.22	TFAP2A-AS1	TFAP2A antisense RNA 1	337	0.8
chr14_22977019_22977170	0.22	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	20923	0.09
chr4_154418637_154418870	0.22	KIAA0922	KIAA0922	31252	0.2
chr9_92444951_92445102	0.22	GADD45G	growth arrest and DNA-damage-inducible, gamma	225073	0.02
chr1_198651611_198651863	0.22	RP11-553K8.5		15547	0.24
chr2_158295494_158296053	0.22	CYTIP	cytohesin 1 interacting protein	153	0.96
chr10_17548651_17548924	0.22	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	52458	0.13
chr3_111258341_111258694	0.22	CD96	CD96 molecule	2339	0.39
chr10_22282945_22283096	0.22	DNAJC1	DnaJ (Hsp40) homolog, subfamily C, member 1	9308	0.27
chr1_234747019_234747378	0.22	IRF2BP2	interferon regulatory factor 2 binding protein 2	1927	0.32
chr3_136677766_136677917	0.22	IL20RB	interleukin 20 receptor beta	990	0.56
chr4_76051776_76051927	0.21	RP11-44F21.2		91817	0.09
chr5_96000350_96000501	0.21	CAST	calpastatin	1668	0.37
chr3_152005414_152005684	0.21	MBNL1	muscleblind-like splicing regulator 1	11645	0.21
chr20_52205540_52206428	0.21	ZNF217	zinc finger protein 217	4394	0.22
chr1_89737700_89738180	0.21	GBP5	guanylate binding protein 5	547	0.77
chr15_71389366_71389517	0.21	THSD4	thrombospondin, type I, domain containing 4	150	0.97
chr2_27273737_27274028	0.21	AGBL5	ATP/GTP binding protein-like 5	6	0.9
chr20_57232821_57232972	0.21	STX16	syntaxin 16	5833	0.18
chr12_9912992_9913534	0.21	CD69	CD69 molecule	234	0.92
chrX_13103844_13104411	0.21	FAM9C	family with sequence similarity 9, member C	41326	0.19
chr9_82427530_82428232	0.21	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	106200	0.08
chr15_93427252_93427403	0.21	CHD2	chromodomain helicase DNA binding protein 2	801	0.63
chr10_17701952_17702103	0.21	STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	15763	0.14
chr6_143264540_143264691	0.21	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	1723	0.46
chr5_49965541_49965784	0.21	PARP8	poly (ADP-ribose) polymerase family, member 8	2271	0.47
chr14_61814123_61814302	0.21	PRKCH	protein kinase C, eta	397	0.87
chr1_241714712_241714945	0.21	KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	17107	0.2
chr19_13841985_13842408	0.21	CCDC130	coiled-coil domain containing 130	378	0.8
chr6_119212181_119212332	0.21	ASF1A	anti-silencing function 1A histone chaperone	3128	0.28
chr12_132671196_132671356	0.21	GALNT9	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)	19061	0.17
chr3_195276037_195276188	0.21	AC091633.3		2693	0.22
chr14_91863541_91863979	0.21	CCDC88C	coiled-coil domain containing 88C	19930	0.21
chr5_56794860_56795362	0.21	ACTBL2	actin, beta-like 2	16475	0.22
chr13_99992298_99992449	0.21	ENSG00000207719	.	16012	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.3	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.2	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1	0.2	GO:0010761	fibroblast migration(GO:0010761)
0.1	0.4	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.2	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.3	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0060789	hair follicle placode formation(GO:0060789)
0.1	0.2	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1	0.2	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	0.2	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.2	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.2	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.1	GO:1900121	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.2	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.2	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.4	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.0	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.2	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.0	0.1	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.3	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.3	GO:0050856	regulation of T cell receptor signaling pathway(GO:0050856)
0.0	0.4	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.2	GO:0043383	negative T cell selection(GO:0043383)
0.0	0.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0046719	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0010523	negative regulation of calcium ion transport into cytosol(GO:0010523)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.6	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.3	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.0	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.1	GO:0071635	negative regulation of transforming growth factor beta production(GO:0071635)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.5	GO:0070303	negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.0	0.2	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	1.1	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.0	GO:0046532	regulation of photoreceptor cell differentiation(GO:0046532)
0.0	0.2	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.3	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0072133	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.0	GO:0090311	regulation of protein deacetylation(GO:0090311) positive regulation of protein deacetylation(GO:0090312)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0048935	peripheral nervous system neuron development(GO:0048935)
0.0	0.1	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.0	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0	0.0	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.0	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.0	GO:0045410	positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.2	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.0	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.3	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.1	GO:0098926	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.2	GO:0000018	regulation of DNA recombination(GO:0000018)
0.0	0.1	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.1	GO:0031954	positive regulation of protein autophosphorylation(GO:0031954)
0.0	0.1	GO:0051828	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.2	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.2	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.2	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.2	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.0	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.1	GO:0010165	response to X-ray(GO:0010165)
0.0	0.4	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0	0.1	GO:0009435	NAD biosynthetic process(GO:0009435)
0.0	0.1	GO:0036465	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.3	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.1	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.0	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.0	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.0	GO:0044321	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.1	GO:0031529	ruffle organization(GO:0031529)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.0	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.2	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.3	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.3	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.2	GO:0016580	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.0	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0061200	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.0	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0001950	obsolete plasma membrane enriched fraction(GO:0001950)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.0	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.0	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	1.4	GO:0009897	external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.2	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.2	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.3	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.2	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.9	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.5	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.4	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.4	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0070513	death domain binding(GO:0070513)
0.0	0.3	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.2	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0008469	histone-arginine N-methyltransferase activity(GO:0008469)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.2	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.6	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.1	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.0	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0033265	choline binding(GO:0033265)
0.0	0.0	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.2	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.0	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.4	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.5	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.0	0.4	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0	0.0	GO:0034584	piRNA binding(GO:0034584)
0.0	0.0	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.0	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.2	GO:0043499	obsolete eukaryotic cell surface binding(GO:0043499)
0.0	0.8	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.0	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.1	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0035591	signaling adaptor activity(GO:0035591)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.0	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.0	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.0	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0016681	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
1.4	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.8	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.4	PID IL3 PATHWAY	IL3-mediated signaling events
0.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.3	PID EPO PATHWAY	EPO signaling pathway
0.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.3	PID IL2 1PATHWAY	IL2-mediated signaling events
0.5	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.3	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.7	PID FOXO PATHWAY	FoxO family signaling
0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.8	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.4	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	PID ALK1 PATHWAY	ALK1 signaling events
0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.2	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.4	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.1	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.2	PID IL27 PATHWAY	IL27-mediated signaling events
0.2	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.1	PID IL12 2PATHWAY	IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.8	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.6	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.3	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.7	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.9	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.4	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.0	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	0.6	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.1	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.3	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0	0.2	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.1	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.3	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.3	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.0	0.0	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.2	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.1	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.3	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.0	0.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.1	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.1	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis