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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for RAD21_SMC3

Z-value: 1.50

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Transcription factors associated with RAD21_SMC3

Gene Symbol	Gene ID	Gene Info
RAD21 Ensembl NCBI GeneCards UniProt	ENSG00000164754.8	RAD21 cohesin complex component
SMC3 Ensembl NCBI GeneCards UniProt	ENSG00000108055.9	structural maintenance of chromosomes 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr8_117887202_117887456	RAD21	224	0.523990	0.62	7.5e-02	Click!
chr8_117883179_117883330	RAD21	3345	0.190759	-0.25	5.1e-01	Click!
chr8_117892142_117892293	RAD21	5112	0.171511	0.24	5.3e-01	Click!
chr8_117884616_117884915	RAD21	1834	0.240314	-0.21	5.8e-01	Click!
chr8_117902849_117903000	RAD21	15819	0.148365	0.19	6.2e-01	Click!
chr10_112296305_112296649	SMC3	30972	0.132365	-0.56	1.1e-01	Click!
chr10_112295759_112296296	SMC3	31422	0.131407	-0.47	2.1e-01	Click!
chr10_112327463_112328125	SMC3	345	0.864914	0.41	2.7e-01	Click!
chr10_112327217_112327415	SMC3	133	0.956732	0.28	4.7e-01	Click!
chr10_112326670_112327053	SMC3	588	0.721803	0.22	5.6e-01	Click!

Activity of the RAD21_SMC3 motif across conditions

Conditions sorted by the z-value of the RAD21_SMC3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_510720_510899	0.84	AC005775.2		2996	0.12
chr14_103571364_103571515	0.75	EXOC3L4	exocyst complex component 3-like 4	2414	0.25
chr19_4872699_4872850	0.71	ENSG00000264899	.	3950	0.13
chr16_23848456_23848777	0.69	PRKCB	protein kinase C, beta	72	0.98
chr10_90595544_90595695	0.68	ANKRD22	ankyrin repeat domain 22	15956	0.16
chr10_81903584_81903735	0.65	PLAC9	placenta-specific 9	11182	0.18
chr19_7744309_7744460	0.64	CTD-3214H19.16		997	0.26
chr11_728044_728195	0.64	AP006621.9		1072	0.28
chr20_30410751_30410929	0.64	MYLK2	myosin light chain kinase 2	3664	0.17
chr3_114582845_114583026	0.63	ZBTB20	zinc finger and BTB domain containing 20	104817	0.08
chr12_94543457_94543730	0.63	PLXNC1	plexin C1	1094	0.57
chr17_63133333_63133484	0.60	RGS9	regulator of G-protein signaling 9	158	0.97
chr1_33520793_33520944	0.59	AK2	adenylate kinase 2	18275	0.16
chr19_41076676_41076827	0.58	SHKBP1	SH3KBP1 binding protein 1	6006	0.15
chr1_152161161_152161312	0.58	FLG-AS1	FLG antisense RNA 1	591	0.7
chr10_82295880_82296244	0.57	RP11-137H2.4		364	0.84
chr19_42210710_42210868	0.56	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	1715	0.23
chr5_39217983_39218134	0.56	FYB	FYN binding protein	1607	0.52
chrX_40737289_40737555	0.56	MED14	mediator complex subunit 14	142639	0.04
chr16_46663412_46663563	0.53	SHCBP1	SHC SH2-domain binding protein 1	7949	0.18
chr17_43212649_43212800	0.53	ACBD4	acyl-CoA binding domain containing 4	290	0.8
chr17_63096707_63096868	0.53	RGS9	regulator of G-protein signaling 9	36779	0.14
chr10_4891951_4892102	0.52	AKR1E2	aldo-keto reductase family 1, member E2	10050	0.23
chr1_40265403_40265603	0.52	RP1-118J21.25		10855	0.13
chr6_13278547_13278698	0.52	RP1-257A7.4		4331	0.22
chr6_36259031_36259182	0.52	PNPLA1	patatin-like phospholipase domain containing 1	20869	0.16
chr14_102990897_102991048	0.52	ANKRD9	ankyrin repeat domain 9	14836	0.15
chr7_142937826_142938131	0.50	GSTK1	glutathione S-transferase kappa 1	3208	0.14
chr22_37595607_37595758	0.50	SSTR3	somatostatin receptor 3	11323	0.12
chr11_57226259_57226422	0.49	RTN4RL2	reticulon 4 receptor-like 2	1682	0.2
chr19_47808671_47808977	0.48	C5AR1	complement component 5a receptor 1	4307	0.16
chr1_26648089_26648240	0.48	UBXN11	UBX domain protein 11	3310	0.14
chr12_54399885_54400449	0.46	HOXC8	homeobox C8	2665	0.09
chr10_70853201_70853352	0.46	SRGN	serglycin	5402	0.21
chr6_159463785_159463936	0.46	TAGAP	T-cell activation RhoGTPase activating protein	2190	0.31
chr20_36919775_36919926	0.45	BPI	bactericidal/permeability-increasing protein	12675	0.15
chr11_65149415_65150138	0.45	SLC25A45	solute carrier family 25, member 45	68	0.95
chr12_131303541_131303831	0.44	ENSG00000238822	.	3788	0.22
chr20_31886970_31887121	0.44	BPIFB1	BPI fold containing family B, member 1	16104	0.16
chr11_111802560_111802798	0.44	ENSG00000238965	.	3555	0.13
chr22_42062744_42062895	0.43	ENSG00000207457	.	12896	0.1
chr11_67381317_67381845	0.43	NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	5884	0.1
chr5_118670778_118671030	0.43	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	2034	0.35
chr2_176944534_176944961	0.42	EVX2	even-skipped homeobox 2	3894	0.12
chr22_24819614_24820020	0.42	ADORA2A	adenosine A2a receptor	218	0.94
chr18_75362846_75362997	0.42	ENSG00000252260	.	212602	0.02
chr11_113906864_113907142	0.42	ZBTB16	zinc finger and BTB domain containing 16	23312	0.18
chrX_48774424_48774575	0.42	PIM2	pim-2 oncogene	1487	0.23
chr19_11647018_11647169	0.41	CNN1	calponin 1, basic, smooth muscle	2439	0.14
chr8_124934794_124934968	0.41	FER1L6	fer-1-like 6 (C. elegans)	33344	0.2
chr3_16925560_16925711	0.40	PLCL2	phospholipase C-like 2	817	0.73
chr6_136547532_136547683	0.40	RP13-143G15.4		874	0.62
chr17_76133551_76133702	0.40	TMC6	transmembrane channel-like 6	5138	0.12
chr14_104367537_104367688	0.40	C14orf2	chromosome 14 open reading frame 2	20219	0.13
chrX_40403109_40403372	0.40	ENSG00000238730	.	8425	0.22
chr15_85114143_85114405	0.39	LINC00933	long intergenic non-protein coding RNA 933	119	0.76
chr17_36762681_36762941	0.39	SRCIN1	SRC kinase signaling inhibitor 1	628	0.62
chr8_57470509_57470758	0.39	RP11-17A4.2		68976	0.13
chr7_27219071_27219572	0.39	RP1-170O19.20	Uncharacterized protein	311	0.56
chr22_22292451_22292602	0.38	LL22NC03-86G7.1		83	0.83
chr1_150533351_150533580	0.38	ADAMTSL4-AS1	ADAMTSL4 antisense RNA 1	504	0.58
chr13_46734728_46734988	0.37	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	7796	0.17
chr2_114006851_114007002	0.36	ENSG00000189223	.	1417	0.35
chr22_24836933_24837084	0.36	ADORA2A	adenosine A2a receptor	8200	0.18
chr19_2475398_2475867	0.36	GADD45B	growth arrest and DNA-damage-inducible, beta	493	0.74
chr13_34116896_34117047	0.36	STARD13	StAR-related lipid transfer (START) domain containing 13	192204	0.03
chr16_89307277_89307470	0.36	RP11-46C24.6		12273	0.11
chr16_81771661_81771865	0.36	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	939	0.7
chr10_95576079_95576230	0.35	LGI1	leucine-rich, glioma inactivated 1	58476	0.12
chr4_185185188_185185495	0.35	ENSG00000221523	.	3243	0.26
chr4_185926512_185926756	0.35	HELT	helt bHLH transcription factor	13361	0.23
chr11_62078778_62078929	0.35	SCGB1D4	secretoglobin, family 1D, member 4	12317	0.11
chr2_96930696_96931115	0.34	TMEM127	transmembrane protein 127	827	0.4
chr13_53542376_53542527	0.34	OLFM4	olfactomedin 4	60443	0.14
chr21_42741228_42741619	0.34	MX2	myxovirus (influenza virus) resistance 2 (mouse)	589	0.77
chr10_74454418_74454598	0.34	MCU	mitochondrial calcium uniporter	2131	0.29
chr3_196411919_196412186	0.34	ENSG00000201441	.	23783	0.11
chrX_152200996_152201209	0.34	PNMA3	paraneoplastic Ma antigen 3	23664	0.12
chr9_139923953_139924104	0.34	ABCA2	ATP-binding cassette, sub-family A (ABC1), member 2	1288	0.16
chr21_38362274_38362496	0.33	HLCS	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	139	0.95
chr19_39902575_39902778	0.33	PLEKHG2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	549	0.52
chr9_130547259_130547434	0.33	CDK9	cyclin-dependent kinase 9	612	0.4
chr22_37656956_37657107	0.32	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	16543	0.14
chr19_16293563_16293744	0.32	FAM32A	family with sequence similarity 32, member A	2538	0.18
chr8_131314714_131314865	0.32	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	38394	0.21
chr2_131090199_131090350	0.32	IMP4	IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)	9524	0.15
chr22_32061724_32061875	0.32	PISD	phosphatidylserine decarboxylase	3381	0.25
chr12_29360340_29360491	0.31	FAR2	fatty acyl CoA reductase 2	16183	0.25
chr11_64637195_64637670	0.31	EHD1	EH-domain containing 1	5706	0.11
chr2_231852070_231852221	0.31	SPATA3	spermatogenesis associated 3	8691	0.16
chrX_118863929_118864080	0.31	SOWAHD	sosondowah ankyrin repeat domain family member D	28572	0.13
chr6_134495232_134495950	0.31	SGK1	serum/glucocorticoid regulated kinase 1	411	0.86
chr6_138725225_138725500	0.31	HEBP2	heme binding protein 2	6	0.98
chrX_108956393_108956544	0.31	ACSL4	acyl-CoA synthetase long-chain family member 4	19974	0.21
chr16_57452807_57452958	0.31	CCL17	chemokine (C-C motif) ligand 17	14203	0.12
chr5_79603471_79603622	0.30	ENSG00000251828	.	1359	0.41
chr19_16493858_16494419	0.30	ENSG00000243745	.	15632	0.14
chr12_6647009_6647306	0.30	RP5-940J5.9		379	0.66
chr19_14545137_14545294	0.30	PKN1	protein kinase N1	910	0.44
chr20_56172175_56172326	0.30	ZBP1	Z-DNA binding protein 1	13071	0.21
chr7_75622802_75623087	0.30	POR	P450 (cytochrome) oxidoreductase	11715	0.16
chr2_68978993_68979334	0.30	ARHGAP25	Rho GTPase activating protein 25	17149	0.23
chr1_154971510_154971950	0.30	ZBTB7B	zinc finger and BTB domain containing 7B	3397	0.09
chrX_43609757_43609908	0.30	MAOA	monoamine oxidase A	94284	0.09
chr1_249101479_249101630	0.30	SH3BP5L	SH3-binding domain protein 5-like	9718	0.16
chr1_47903418_47903665	0.29	FOXD2	forkhead box D2	1852	0.27
chr12_94543061_94543212	0.29	PLXNC1	plexin C1	637	0.76
chr3_52305451_52305846	0.29	ENSG00000199150	.	3269	0.11
chr19_46272674_46272825	0.29	SIX5	SIX homeobox 5	265	0.73
chr16_66864896_66865106	0.29	NAE1	NEDD8 activating enzyme E1 subunit 1	101	0.95
chr1_202968488_202968639	0.29	TMEM183A	transmembrane protein 183A	7951	0.12
chr17_76418239_76418390	0.29	AC061992.1	Uncharacterized protein	4095	0.17
chr10_105127693_105127877	0.28	TAF5	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	61	0.96
chr19_42302858_42303009	0.28	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	1848	0.24
chr8_23315005_23315175	0.28	ENTPD4	ectonucleoside triphosphate diphosphohydrolase 4	70	0.97
chr1_95320110_95320311	0.28	ENSG00000237416	.	772	0.66
chrX_52964079_52964300	0.28	FAM156A	family with sequence similarity 156, member A	21340	0.17
chr14_75981526_75981933	0.27	BATF	basic leucine zipper transcription factor, ATF-like	7039	0.21
chr11_8008537_8008688	0.27	EIF3F	eukaryotic translation initiation factor 3, subunit F	175	0.92
chr6_159125269_159125420	0.27	SYTL3	synaptotagmin-like 3	41149	0.13
chr19_49138973_49139430	0.27	DBP	D site of albumin promoter (albumin D-box) binding protein	1308	0.22
chr1_212838734_212839243	0.27	ENSG00000207491	.	26618	0.12
chrX_54666271_54666506	0.27	GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	109713	0.06
chr2_24713646_24713947	0.27	NCOA1	nuclear receptor coactivator 1	1005	0.64
chr9_81310465_81310616	0.27	PSAT1	phosphoserine aminotransferase 1	398481	0.01
chr2_152204695_152204846	0.27	TNFAIP6	tumor necrosis factor, alpha-induced protein 6	9336	0.17
chr1_2126776_2126927	0.27	C1orf86	chromosome 1 open reading frame 86	638	0.58
chr16_75032327_75032816	0.26	ZNRF1	zinc and ring finger 1, E3 ubiquitin protein ligase	357	0.89
chr19_41847643_41847794	0.26	TGFB1	transforming growth factor, beta 1	217	0.87
chr3_49943854_49944005	0.26	CTD-2330K9.3	Uncharacterized protein	2509	0.14
chr11_48131630_48131789	0.26	ENSG00000263693	.	13375	0.23
chr11_20408753_20408968	0.26	PRMT3	protein arginine methyltransferase 3	216	0.95
chr22_17652535_17653083	0.26	CECR5	cat eye syndrome chromosome region, candidate 5	6632	0.16
chr12_124377548_124377699	0.26	DNAH10	dynein, axonemal, heavy chain 10	15237	0.11
chr7_137583870_137584060	0.26	CREB3L2	cAMP responsive element binding protein 3-like 2	29050	0.18
chr11_723305_723456	0.26	AP006621.9		3667	0.1
chr14_50053552_50053772	0.26	RN7SL1	RNA, 7SL, cytoplasmic 1	364	0.55
chr17_38474976_38475621	0.26	RARA	retinoic acid receptor, alpha	761	0.52
chr14_105189941_105190399	0.26	ADSSL1	adenylosuccinate synthase like 1	353	0.81
chr11_2172831_2172982	0.26	IGF2	insulin-like growth factor 2 (somatomedin A)	2073	0.18
chr4_17550872_17551165	0.26	ENSG00000238536	.	20458	0.13
chr13_96130880_96131359	0.26	CLDN10	claudin 10	45261	0.16
chr17_78997611_78997870	0.26	BAIAP2	BAI1-associated protein 2	11210	0.12
chr9_19048749_19049283	0.26	RRAGA	Ras-related GTP binding A	356	0.81
chr2_28825128_28825469	0.26	PLB1	phospholipase B1	512	0.83
chr16_2390815_2390992	0.26	ABCA3	ATP-binding cassette, sub-family A (ABC1), member 3	156	0.92
chrX_153978145_153979054	0.25	GAB3	GRB2-associated binding protein 3	733	0.55
chr9_132244274_132244823	0.25	ENSG00000264298	.	3713	0.27
chr1_155942046_155942197	0.25	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	10	0.95
chr10_90343073_90343515	0.25	RNLS	renalase, FAD-dependent amine oxidase	324	0.86
chr22_17587383_17587676	0.25	CECR6	cat eye syndrome chromosome region, candidate 6	14614	0.14
chr1_149860084_149860235	0.25	HIST2H2AB	histone cluster 2, H2ab	693	0.28
chr3_128564835_128565137	0.25	RP11-723O4.2		19461	0.16
chr9_32572122_32572855	0.25	NDUFB6	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa	669	0.62
chr17_71817273_71817424	0.25	SDK2	sidekick cell adhesion molecule 2	177120	0.03
chr1_9202388_9202539	0.25	ENSG00000207865	.	9373	0.17
chr14_103589198_103589361	0.25	TNFAIP2	tumor necrosis factor, alpha-induced protein 2	519	0.76
chr11_45864761_45864912	0.25	CRY2	cryptochrome 2 (photolyase-like)	3833	0.19
chr4_141174038_141174780	0.24	SCOC	short coiled-coil protein	4031	0.26
chr10_134364622_134364773	0.24	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	13054	0.21
chr12_124018329_124018683	0.24	RILPL1	Rab interacting lysosomal protein-like 1	241	0.89
chr15_41198500_41199127	0.24	VPS18	vacuolar protein sorting 18 homolog (S. cerevisiae)	12148	0.11
chr16_67580972_67581123	0.24	FAM65A	family with sequence similarity 65, member A	2750	0.12
chr5_43105962_43106287	0.24	ZNF131	zinc finger protein 131	14861	0.18
chr1_145589458_145589609	0.24	NUDT17	nudix (nucleoside diphosphate linked moiety X)-type motif 17	94	0.94
chr16_30441543_30441841	0.24	DCTPP1	dCTP pyrophosphatase 1	296	0.74
chr6_26596047_26596198	0.24	ABT1	activator of basal transcription 1	1058	0.52
chr8_41685722_41686425	0.24	ENSG00000241834	.	11784	0.18
chr11_104914891_104915295	0.24	CARD16	caspase recruitment domain family, member 16	941	0.54
chr2_37502502_37502653	0.24	PRKD3	protein kinase D3	830	0.57
chr1_221055703_221055854	0.24	HLX	H2.0-like homeobox	1194	0.46
chr5_176882439_176883305	0.24	DBN1	drebrin 1	6518	0.1
chr7_148663870_148664057	0.24	ENSG00000252316	.	3556	0.17
chr1_11779431_11780126	0.24	AGTRAP	angiotensin II receptor-associated protein	16363	0.11
chr16_67193901_67194322	0.24	TRADD	TNFRSF1A-associated via death domain	90	0.63
chr8_22551556_22552015	0.24	EGR3	early growth response 3	970	0.44
chr17_74117442_74118068	0.24	EXOC7	exocyst complex component 7	98	0.95
chr3_136732781_136732932	0.24	IL20RB-AS1	IL20RB antisense RNA 1	31818	0.19
chr7_43878481_43878681	0.24	MRPS24	mitochondrial ribosomal protein S24	30575	0.14
chr6_44225465_44225616	0.23	SLC35B2	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2	249	0.84
chr9_100955406_100955634	0.23	CORO2A	coronin, actin binding protein, 2A	598	0.77
chr19_17416354_17416505	0.23	MRPL34	mitochondrial ribosomal protein L34	48	0.92
chr12_52417641_52417792	0.23	NR4A1	nuclear receptor subfamily 4, group A, member 1	1100	0.39
chr8_134307720_134307932	0.23	NDRG1	N-myc downstream regulated 1	953	0.67
chr13_78052035_78052755	0.23	SCEL	sciellin	57414	0.14
chr19_6481304_6482171	0.23	DENND1C	DENN/MADD domain containing 1C	27	0.95
chr5_179517510_179517661	0.23	RNF130	ring finger protein 130	18467	0.19
chr15_75077997_75078148	0.23	CSK	c-src tyrosine kinase	2813	0.16
chr2_238330261_238330412	0.23	AC112721.1	Uncharacterized protein	3583	0.24
chr1_152432501_152432949	0.23	CRNN	cornulin	45986	0.09
chr17_7146487_7146682	0.23	GABARAP	GABA(A) receptor-associated protein	495	0.51
chr6_110026512_110026663	0.23	FIG4	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	3664	0.28
chr2_25015571_25015910	0.22	CENPO	centromere protein O	274	0.69
chr8_25041176_25041327	0.22	DOCK5	dedicator of cytokinesis 5	987	0.56
chr19_43032396_43032749	0.22	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	26	0.98
chr17_7340388_7340539	0.22	RP11-104H15.9		379	0.55
chr2_113384253_113384510	0.22	SLC20A1	solute carrier family 20 (phosphate transporter), member 1	19053	0.16
chr3_63964903_63965338	0.22	ATXN7	ataxin 7	11700	0.14
chr1_21619720_21620176	0.22	RP5-1071N3.1		165	0.91
chr7_155137689_155137840	0.22	BLACE	B-cell acute lymphoblastic leukemia expressed	22865	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RAD21_SMC3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.2	0.5	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.1	0.3	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.1	0.3	GO:0009191	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.1	0.3	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.1	0.2	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.1	0.2	GO:0006167	AMP biosynthetic process(GO:0006167)
0.1	0.2	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.1	0.2	GO:0051503	adenine nucleotide transport(GO:0051503)
0.1	0.2	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.2	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.2	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0050961	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.3	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.0	0.2	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.2	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.2	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.1	GO:1903115	regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0	0.3	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0042635	positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0	0.2	GO:0060023	soft palate development(GO:0060023)
0.0	0.2	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.2	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.2	GO:0036473	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.1	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.8	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.0	0.2	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.3	GO:0032770	positive regulation of monooxygenase activity(GO:0032770)
0.0	0.1	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0	0.2	GO:1903078	positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0	0.1	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.1	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.1	GO:1901984	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0060996	dendritic spine development(GO:0060996)
0.0	0.1	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.1	GO:0060263	regulation of respiratory burst(GO:0060263)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.0	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.0	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.3	GO:0045408	regulation of interleukin-6 biosynthetic process(GO:0045408)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.3	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.2	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.1	GO:0048342	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0	0.1	GO:0005997	xylulose metabolic process(GO:0005997)
0.0	0.1	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.1	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.2	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.1	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.0	0.1	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.2	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.1	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.0	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.0	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.1	GO:0019317	fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0	0.1	GO:0031111	negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0	0.0	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.0	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.0	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.0	GO:1903959	regulation of anion transmembrane transport(GO:1903959)
0.0	0.1	GO:0060317	cardiac epithelial to mesenchymal transition(GO:0060317)
0.0	0.0	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.0	GO:0032627	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.0	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.2	GO:0021522	spinal cord motor neuron differentiation(GO:0021522)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.0	GO:0042661	regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0	0.0	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.1	GO:0006386	transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386)
0.0	0.0	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.0	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.0	GO:0072162	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.0	GO:0006012	galactose metabolic process(GO:0006012)
0.0	0.0	GO:0033345	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.0	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.2	GO:0006336	DNA replication-independent nucleosome assembly(GO:0006336) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641)
0.0	0.0	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0045008	depyrimidination(GO:0045008)
0.0	0.0	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.1	GO:0001967	suckling behavior(GO:0001967)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.1	0.2	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.2	GO:0042599	lamellar body(GO:0042599)
0.0	0.2	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.3	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.3	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.4	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.2	GO:0000931	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	0.1	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.0	GO:0000125	PCAF complex(GO:0000125)
0.0	0.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.3	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.3	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.0	GO:0008537	proteasome activator complex(GO:0008537)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.2	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0071817	MMXD complex(GO:0071817)
0.0	0.1	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.0	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0	0.2	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.1	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.1	GO:0071547	piP-body(GO:0071547)
0.0	0.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.2	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	0.1	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0000782	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0	0.0	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.0	GO:0031428	box C/D snoRNP complex(GO:0031428)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.5	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.1	0.2	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.1	0.3	GO:0032552	deoxyribonucleotide binding(GO:0032552)
0.1	0.2	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.1	0.2	GO:0001849	complement component C1q binding(GO:0001849)
0.1	0.2	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.1	0.2	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.3	GO:0009374	biotin binding(GO:0009374)
0.0	0.3	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.2	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.2	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.2	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.2	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.2	GO:0070513	death domain binding(GO:0070513)
0.0	0.3	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.4	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.2	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.3	GO:0017069	snRNA binding(GO:0017069)
0.0	0.1	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.2	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0032052	bile acid binding(GO:0032052)
0.0	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.4	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.1	GO:0032138	single base insertion or deletion binding(GO:0032138)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.6	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.2	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0	0.2	GO:0016986	obsolete transcription initiation factor activity(GO:0016986)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.2	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.3	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.1	GO:0016744	transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0	0.0	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.1	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.0	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.0	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.0	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0070567	cytidylyltransferase activity(GO:0070567)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	0.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.6	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.1	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.1	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.3	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.5	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.6	PID FOXO PATHWAY	FoxO family signaling
0.0	0.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.3	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.2	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.0	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.1	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.3	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.7	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.5	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.2	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.5	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.6	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	REACTOME GAB1 SIGNALOSOME	Genes involved in GAB1 signalosome
0.3	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.4	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.3	REACTOME PI3K EVENTS IN ERBB4 SIGNALING	Genes involved in PI3K events in ERBB4 signaling
0.3	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.1	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.4	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival

Results for RAD21_SMC3

Z-value: 1.50

Motif logo

Transcription factors associated with RAD21_SMC3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the RAD21_SMC3 motif across conditions

Conditions sorted by the z-value of the RAD21_SMC3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RAD21_SMC3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: