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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RARB

Z-value: 1.32

Motif logo

Transcription factors associated with RARB

Gene Symbol	Gene ID	Gene Info
RARB Ensembl NCBI GeneCards UniProt	ENSG00000077092.14	RARB

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
RARB	chr3_25496127_25496278	3599	0.335449	-0.89	1.2e-03	Click!
RARB	chr3_25497685_25497836	2041	0.437538	-0.86	3.1e-03	Click!
RARB	chr3_25469781_25469984	80	0.983222	-0.86	3.2e-03	Click!
RARB	chr3_25465504_25465718	4143	0.319253	-0.86	3.3e-03	Click!
RARB	chr3_25495752_25495903	3974	0.324844	-0.85	3.9e-03	Click!

Activity of the RARB motif across conditions

Conditions sorted by the z-value of the RARB motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_98334070_98334346	0.86	ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	4185	0.2
chr14_22961374_22961769	0.84	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	5400	0.11
chr2_173327465_173327877	0.82	AC078883.3		3069	0.24
chrX_70330282_70330478	0.81	IL2RG	interleukin 2 receptor, gamma	368	0.76
chr6_143189309_143189460	0.77	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	31200	0.22
chr6_152504718_152504928	0.73	SYNE1	spectrin repeat containing, nuclear envelope 1	15324	0.29
chr3_183273082_183273407	0.73	KLHL6	kelch-like family member 6	233	0.92
chr14_22950797_22950948	0.72	TRAJ55	T cell receptor alpha joining 55 (pseudogene)	186	0.79
chr17_76127167_76127361	0.71	TMC8	transmembrane channel-like 8	395	0.51
chr13_52397765_52397916	0.68	RP11-327P2.5		19407	0.17
chrX_11780001_11780185	0.66	MSL3	male-specific lethal 3 homolog (Drosophila)	2346	0.44
chr6_128221812_128222507	0.66	THEMIS	thymocyte selection associated	56	0.99
chr3_16329814_16329965	0.65	OXNAD1	oxidoreductase NAD-binding domain containing 1	19141	0.15
chr2_120687736_120687954	0.65	PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	493	0.83
chr14_22949623_22949774	0.64	ENSG00000251002	.	580	0.49
chr9_139990412_139990681	0.64	ENSG00000199411	.	1749	0.12
chr17_59981888_59982128	0.63	INTS2	integrator complex subunit 2	22779	0.17
chr19_23984835_23985137	0.63	RP11-255H23.2		11412	0.19
chr3_196368779_196369009	0.62	PIGX	phosphatidylinositol glycan anchor biosynthesis, class X	2248	0.2
chr10_73843197_73843461	0.60	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	4757	0.26
chrX_48772131_48772362	0.60	PIM2	pim-2 oncogene	766	0.45
chr22_37680309_37680627	0.59	CYTH4	cytohesin 4	1940	0.3
chrX_78202204_78202379	0.58	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	1373	0.61
chr2_175460517_175460758	0.58	WIPF1	WAS/WASL interacting protein family, member 1	1856	0.33
chr3_121378552_121379115	0.58	HCLS1	hematopoietic cell-specific Lyn substrate 1	912	0.5
chr21_15917471_15917848	0.58	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	1003	0.63
chr1_151129872_151130112	0.58	SCNM1	sodium channel modifier 1	852	0.29
chr22_39639623_39639926	0.55	PDGFB	platelet-derived growth factor beta polypeptide	753	0.58
chr13_99959249_99959863	0.55	GPR183	G protein-coupled receptor 183	103	0.97
chr6_90788160_90788311	0.54	ENSG00000222078	.	77010	0.1
chr19_42061527_42061721	0.54	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	5738	0.18
chrX_78406189_78406340	0.54	GPR174	G protein-coupled receptor 174	20205	0.29
chr4_40202563_40202865	0.53	RHOH	ras homolog family member H	750	0.7
chr5_130881605_130881983	0.53	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	13068	0.29
chr7_138779169_138779413	0.53	ZC3HAV1	zinc finger CCCH-type, antiviral 1	14809	0.2
chr13_75890123_75890274	0.53	TBC1D4	TBC1 domain family, member 4	25469	0.22
chr8_8727283_8727434	0.52	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	23797	0.18
chr10_14606149_14606418	0.52	FAM107B	family with sequence similarity 107, member B	7746	0.26
chr2_87830138_87830289	0.52	RP11-1399P15.1		52660	0.16
chr11_128387865_128388196	0.51	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	4066	0.27
chr7_138778953_138779104	0.50	ZC3HAV1	zinc finger CCCH-type, antiviral 1	15015	0.2
chr2_120988902_120989053	0.50	TMEM185B	transmembrane protein 185B	7993	0.17
chr5_130849992_130850161	0.50	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	6226	0.32
chr3_107844575_107844939	0.50	CD47	CD47 molecule	34885	0.22
chr18_56105832_56106078	0.49	ENSG00000207778	.	12351	0.17
chr2_112177530_112177803	0.49	ENSG00000266139	.	98998	0.09
chr19_10449910_10450285	0.48	ICAM3	intercellular adhesion molecule 3	198	0.86
chr3_109525427_109525578	0.47	ENSG00000265956	.	203827	0.03
chr16_27414444_27414647	0.47	IL21R	interleukin 21 receptor	122	0.97
chr2_213976639_213976790	0.47	IKZF2	IKAROS family zinc finger 2 (Helios)	36639	0.21
chr5_156611761_156611912	0.47	ITK	IL2-inducible T-cell kinase	3999	0.16
chr5_79484995_79485498	0.47	ENSG00000239159	.	50162	0.12
chr14_22996017_22996172	0.47	TRAJ15	T cell receptor alpha joining 15	2486	0.17
chr1_32718292_32718517	0.46	LCK	lymphocyte-specific protein tyrosine kinase	1529	0.2
chr12_123560353_123560523	0.46	PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	204	0.94
chr3_152000711_152000862	0.45	MBNL1-AS1	MBNL1 antisense RNA 1	13442	0.21
chr6_15340960_15341111	0.45	ENSG00000201519	.	16332	0.2
chrX_153361307_153361458	0.44	MECP2	methyl CpG binding protein 2 (Rett syndrome)	1054	0.45
chr12_22485870_22486021	0.44	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	1152	0.64
chr6_154567141_154567292	0.44	IPCEF1	interaction protein for cytohesin exchange factors 1	774	0.79
chr15_26095881_26096079	0.43	ENSG00000266517	.	2008	0.32
chrX_78417451_78417673	0.43	GPR174	G protein-coupled receptor 174	8907	0.32
chr9_138981896_138982047	0.43	NACC2	NACC family member 2, BEN and BTB (POZ) domain containing	5160	0.22
chr20_62199083_62199345	0.43	HELZ2	helicase with zinc finger 2, transcriptional coactivator	213	0.88
chr13_74807358_74807666	0.43	ENSG00000206617	.	55839	0.16
chr17_10603321_10603720	0.43	ADPRM	ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent	2609	0.18
chr1_154300198_154300512	0.42	ATP8B2	ATPase, aminophospholipid transporter, class I, type 8B, member 2	79	0.94
chr11_122722660_122722811	0.42	CRTAM	cytotoxic and regulatory T cell molecule	10276	0.21
chr1_39684129_39684368	0.42	RP11-416A14.1		12064	0.17
chr5_40515444_40515595	0.42	ENSG00000199552	.	139546	0.05
chr14_99735608_99735969	0.42	BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	1777	0.38
chr3_195267203_195267354	0.41	PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	2898	0.21
chr1_198632029_198632471	0.41	RP11-553K8.5		3940	0.29
chr11_128379892_128380047	0.41	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	4680	0.27
chr2_225265820_225265971	0.41	FAM124B	family with sequence similarity 124B	816	0.76
chr2_227703538_227703689	0.41	RHBDD1	rhomboid domain containing 1	1349	0.49
chr2_231090336_231091061	0.40	SP140	SP140 nuclear body protein	219	0.54
chr2_201331503_201331739	0.40	SPATS2L	spermatogenesis associated, serine-rich 2-like	26249	0.16
chr8_21769513_21769765	0.40	DOK2	docking protein 2, 56kDa	1535	0.4
chr5_14676474_14676736	0.40	FAM105B	family with sequence similarity 105, member B	5054	0.24
chr13_79967234_79967432	0.40	ENSG00000252496	.	3567	0.23
chr1_156785458_156785677	0.39	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	119	0.91
chr7_123603687_123603838	0.39	SPAM1	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	16008	0.19
chr17_66196156_66196600	0.39	AMZ2	archaelysin family metallopeptidase 2	47337	0.11
chr12_3861008_3861159	0.39	EFCAB4B	EF-hand calcium binding domain 4B	1180	0.56
chr10_70444201_70444500	0.39	RP11-119F7.5		13907	0.15
chr2_109237700_109238010	0.39	LIMS1	LIM and senescent cell antigen-like domains 1	133	0.97
chr3_128507459_128507964	0.39	ENSG00000244232	.	3721	0.22
chr16_87241773_87241924	0.39	RP11-899L11.3		7673	0.23
chr6_11852612_11852763	0.39	ADTRP	androgen-dependent TFPI-regulating protein	45408	0.18
chr17_4618141_4618477	0.39	ARRB2	arrestin, beta 2	575	0.53
chr1_158978812_158979065	0.38	IFI16	interferon, gamma-inducible protein 16	153	0.96
chr2_99386487_99386649	0.38	ENSG00000201070	.	12305	0.21
chr15_63483779_63483976	0.38	RAB8B	RAB8B, member RAS oncogene family	2072	0.34
chr2_143886988_143887259	0.38	ARHGAP15	Rho GTPase activating protein 15	240	0.95
chr7_87318553_87318704	0.38	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	23936	0.21
chr4_90224526_90224677	0.38	GPRIN3	GPRIN family member 3	4560	0.34
chr15_61012992_61013143	0.38	ENSG00000212625	.	15901	0.2
chr12_15112961_15113206	0.38	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	1117	0.46
chr2_212476372_212476523	0.38	ENSG00000199585	.	76069	0.13
chr15_81584764_81585010	0.37	IL16	interleukin 16	4367	0.24
chr1_12533236_12533387	0.37	VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	5293	0.24
chr14_99710942_99711195	0.37	AL109767.1		18217	0.2
chr7_104584232_104584453	0.37	ENSG00000251911	.	27392	0.16
chr21_46332173_46332515	0.37	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	969	0.4
chr1_9882638_9884014	0.37	CLSTN1	calsyntenin 1	716	0.65
chr19_50002038_50002189	0.36	ENSG00000200530	.	1136	0.16
chr19_50062782_50062933	0.36	NOSIP	nitric oxide synthase interacting protein	1030	0.27
chr5_141467902_141468053	0.36	NDFIP1	Nedd4 family interacting protein 1	20093	0.2
chr1_160547631_160547822	0.36	CD84	CD84 molecule	1537	0.33
chr21_30204306_30204701	0.36	N6AMT1	N-6 adenine-specific DNA methyltransferase 1 (putative)	53190	0.14
chr19_18414393_18414628	0.36	LSM4	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)	12559	0.09
chr14_100534053_100534268	0.36	EVL	Enah/Vasp-like	1386	0.36
chr1_12230241_12230523	0.36	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	3322	0.2
chr3_71351252_71351403	0.35	FOXP1	forkhead box P1	2584	0.35
chr1_100866151_100866481	0.35	ENSG00000216067	.	21985	0.18
chr9_36485594_36485745	0.35	RNF38	ring finger protein 38	84474	0.09
chrX_40430227_40430433	0.35	ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	9816	0.21
chr11_14722182_14722400	0.35	PDE3B	phosphodiesterase 3B, cGMP-inhibited	56914	0.14
chr14_22947593_22947744	0.35	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	2372	0.15
chr2_106392629_106392859	0.35	NCK2	NCK adaptor protein 2	30556	0.23
chr17_56404642_56404793	0.35	BZRAP1	benzodiazepine receptor (peripheral) associated protein 1	728	0.47
chr7_92744983_92745334	0.35	SAMD9	sterile alpha motif domain containing 9	2117	0.37
chr1_207088744_207089040	0.35	FAIM3	Fas apoptotic inhibitory molecule 3	6320	0.15
chr6_128214596_128214747	0.35	THEMIS	thymocyte selection associated	7432	0.31
chr9_117353596_117353986	0.34	ATP6V1G1	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1	3765	0.18
chr1_160635203_160635434	0.34	RP11-404F10.2		5250	0.17
chr13_46753268_46753419	0.34	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	3116	0.21
chr7_26704596_26704975	0.34	C7orf71	chromosome 7 open reading frame 71	27295	0.23
chr22_44391651_44392034	0.34	PARVB	parvin, beta	3249	0.27
chr19_16482178_16482409	0.34	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	9529	0.15
chr1_24832184_24832335	0.34	RCAN3	RCAN family member 3	1798	0.32
chr6_36171723_36172059	0.34	BRPF3	bromodomain and PHD finger containing, 3	300	0.89
chr14_32672059_32672251	0.33	ENSG00000202337	.	320	0.8
chr14_99737865_99738043	0.33	BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	93	0.97
chr6_154983150_154983301	0.33	SCAF8	SR-related CTD-associated factor 8	71234	0.12
chr19_17136985_17137234	0.33	CPAMD8	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	516	0.7
chr5_103287875_103288026	0.33	ENSG00000201910	.	146625	0.05
chr2_191883276_191883427	0.33	AC067945.2		671	0.6
chrX_56792324_56792475	0.33	ENSG00000204272	.	36707	0.23
chr1_111162215_111162656	0.32	KCNA2	potassium voltage-gated channel, shaker-related subfamily, member 2	11661	0.19
chr5_171610252_171610403	0.32	STK10	serine/threonine kinase 10	5063	0.21
chr15_37350605_37350756	0.32	ENSG00000206676	.	7549	0.24
chr11_128566255_128566406	0.32	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	412	0.82
chr13_100072035_100072186	0.32	ENSG00000266207	.	33613	0.16
chr11_128380151_128380303	0.32	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	4938	0.27
chr1_29253197_29253478	0.32	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12246	0.18
chr2_8655557_8655708	0.32	AC011747.7		160264	0.04
chr1_198632521_198632794	0.32	RP11-553K8.5		3533	0.3
chr3_18484841_18485200	0.32	SATB1	SATB homeobox 1	1345	0.38
chr2_68964970_68965234	0.31	ARHGAP25	Rho GTPase activating protein 25	3088	0.33
chr11_118743547_118743698	0.31	CXCR5	chemokine (C-X-C motif) receptor 5	10853	0.1
chr7_129546585_129546878	0.31	UBE2H	ubiquitin-conjugating enzyme E2H	44436	0.1
chr1_160548800_160549253	0.31	CD84	CD84 molecule	237	0.91
chr10_26727488_26728306	0.31	APBB1IP	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	543	0.85
chr2_219762346_219762497	0.31	WNT10A	wingless-type MMTV integration site family, member 10A	15538	0.1
chr18_12838026_12838271	0.31	PTPN2	protein tyrosine phosphatase, non-receptor type 2	1325	0.51
chr21_26945811_26946271	0.31	ENSG00000234883	.	251	0.92
chr18_60198500_60198651	0.30	ZCCHC2	zinc finger, CCHC domain containing 2	7723	0.28
chr10_135203313_135203500	0.30	RP11-108K14.8	Mitochondrial GTPase 1	932	0.33
chr5_79032666_79032916	0.30	CMYA5	cardiomyopathy associated 5	47091	0.16
chr3_4867321_4867754	0.30	ENSG00000239126	.	52849	0.14
chr2_86080820_86081072	0.30	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	13831	0.17
chr7_2559806_2560865	0.30	LFNG	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	839	0.55
chr20_5574610_5574761	0.30	GPCPD1	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	16987	0.24
chrX_147463091_147463259	0.30	AC002368.4		118960	0.06
chr12_55376808_55376997	0.29	TESPA1	thymocyte expressed, positive selection associated 1	1280	0.52
chr11_67008860_67009245	0.29	KDM2A	lysine (K)-specific demethylase 2A	1534	0.28
chr20_47443528_47443935	0.29	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	689	0.79
chr1_226921103_226921254	0.29	ITPKB	inositol-trisphosphate 3-kinase B	3981	0.28
chr16_49497467_49497618	0.29	C16orf78	chromosome 16 open reading frame 78	89808	0.09
chr4_71862773_71862924	0.29	DCK	deoxycytidine kinase	3493	0.32
chr6_10529624_10529892	0.29	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	1169	0.49
chr9_21444522_21444673	0.29	IFNA1	interferon, alpha 1	4157	0.18
chr9_82239099_82239364	0.29	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	28277	0.28
chr1_207090442_207090593	0.29	FAIM3	Fas apoptotic inhibitory molecule 3	4695	0.16
chr7_76541809_76541980	0.29	ENSG00000231183	.	1472	0.46
chr1_9690042_9690512	0.29	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	21513	0.15
chr9_114836879_114837030	0.29	RP11-4O1.2		36944	0.14
chr11_128161993_128162144	0.29	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	213221	0.02
chr20_3137726_3137992	0.29	UBOX5	U-box domain containing 5	2663	0.16
chr6_152506299_152506551	0.28	SYNE1	spectrin repeat containing, nuclear envelope 1	16926	0.28
chr11_94801551_94801758	0.28	ENDOD1	endonuclease domain containing 1	21320	0.19
chr2_10523080_10523233	0.28	HPCAL1	hippocalcin-like 1	36991	0.15
chr8_22301822_22301996	0.28	PPP3CC	protein phosphatase 3, catalytic subunit, gamma isozyme	3031	0.21
chr17_35860978_35861129	0.28	DUSP14	dual specificity phosphatase 14	8928	0.19
chr17_80063977_80064793	0.28	CCDC57	coiled-coil domain containing 57	4659	0.1
chr10_17726067_17726351	0.28	ENSG00000251959	.	5022	0.18
chr1_160174806_160174972	0.28	PEA15	phosphoprotein enriched in astrocytes 15	238	0.51
chr4_109571201_109571501	0.28	OSTC	oligosaccharyltransferase complex subunit (non-catalytic)	389	0.83
chr6_144980546_144980779	0.28	UTRN	utrophin	318	0.95
chr6_45465042_45465193	0.28	RUNX2	runt-related transcription factor 2	74895	0.11
chr15_32634653_32635232	0.28	ENSG00000221444	.	50731	0.09
chr10_5333412_5333586	0.28	AKR1C7P	aldo-keto reductase family 1, member C7, pseudogene	3066	0.27
chr10_111817998_111818272	0.27	ADD3	adducin 3 (gamma)	50413	0.13
chr10_90519770_90519921	0.27	LIPN	lipase, family member N	1318	0.44
chrX_70328757_70329094	0.27	IL2RG	interleukin 2 receptor, gamma	193	0.89
chr16_67399178_67399329	0.27	LRRC36	leucine rich repeat containing 36	17947	0.09
chr12_15104110_15104261	0.27	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	100	0.96
chr9_77635535_77635794	0.27	RP11-197P3.5		4712	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RARB

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.4	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.4	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.6	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.3	GO:0072239	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.1	0.3	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	1.0	GO:0043368	positive T cell selection(GO:0043368)
0.1	0.7	GO:0002467	germinal center formation(GO:0002467)
0.1	0.3	GO:0010508	positive regulation of autophagy(GO:0010508)
0.1	0.2	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.1	0.3	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.8	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.1	0.3	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.1	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0007386	compartment pattern specification(GO:0007386)
0.1	0.2	GO:0019372	lipoxygenase pathway(GO:0019372)
0.1	0.2	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.1	0.2	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.1	0.2	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1	0.3	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.1	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.2	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.6	GO:0030224	monocyte differentiation(GO:0030224)
0.0	0.1	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.0	0.4	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.2	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.2	GO:0051458	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.5	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0032291	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:1900121	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0070933	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.3	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.4	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0016242	regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.5	GO:0030101	natural killer cell activation(GO:0030101)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.0	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.0	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.1	GO:0061756	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	0.1	GO:0046325	negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0010587	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0002329	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.2	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.0	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.1	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.4	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.1	GO:0002834	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.1	GO:0042953	lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0	0.1	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.4	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0	0.2	GO:0034383	low-density lipoprotein particle clearance(GO:0034383)
0.0	0.5	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.3	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.1	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.0	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.1	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.2	GO:0042423	catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:1902019	regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0	0.1	GO:0070076	histone lysine demethylation(GO:0070076)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.2	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.1	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0034391	smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0031659	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.0	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.4	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.1	GO:1904181	positive regulation of mitochondrial depolarization(GO:0051901) positive regulation of membrane depolarization(GO:1904181)
0.0	0.1	GO:0003057	regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0	0.1	GO:0050884	neuromuscular process controlling posture(GO:0050884)
0.0	0.1	GO:0002230	positive regulation of defense response to virus by host(GO:0002230)
0.0	0.1	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0009180	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.0	GO:0003085	negative regulation of systemic arterial blood pressure(GO:0003085)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0002246	wound healing involved in inflammatory response(GO:0002246) inflammatory response to wounding(GO:0090594)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:0021894	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.4	GO:0043966	histone H3 acetylation(GO:0043966)
0.0	0.7	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.0	0.1	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.0	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.0	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.0	0.0	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0043666	regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0043101	purine-containing compound salvage(GO:0043101)
0.0	0.0	GO:0015669	gas transport(GO:0015669)
0.0	0.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0001662	behavioral fear response(GO:0001662)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.2	GO:0030838	positive regulation of actin filament polymerization(GO:0030838)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.0	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.0	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.1	GO:0045176	apical protein localization(GO:0045176)
0.0	0.2	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0	0.0	GO:0032119	sequestering of zinc ion(GO:0032119)
0.0	0.0	GO:0042508	tyrosine phosphorylation of Stat1 protein(GO:0042508)
0.0	0.0	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.1	GO:0016180	snRNA processing(GO:0016180)
0.0	0.0	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.0	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.0	0.0	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.0	GO:1902803	regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.0	GO:1902170	cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:0009191	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.3	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.0	GO:0032372	negative regulation of sterol transport(GO:0032372) negative regulation of cholesterol transport(GO:0032375)
0.0	0.1	GO:0051828	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.0	GO:0043620	regulation of DNA-templated transcription in response to stress(GO:0043620)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.0	0.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.0	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.1	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.1	GO:0006386	transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386)
0.0	0.1	GO:0032607	interferon-alpha production(GO:0032607) regulation of interferon-alpha production(GO:0032647) positive regulation of interferon-alpha production(GO:0032727)
0.0	0.1	GO:0032092	positive regulation of protein binding(GO:0032092)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.0	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0032981	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.1	GO:0001706	endoderm formation(GO:0001706)
0.0	0.0	GO:0032715	negative regulation of interleukin-6 production(GO:0032715)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0072487	MSL complex(GO:0072487)
0.1	0.4	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.3	GO:0043218	compact myelin(GO:0043218)
0.1	0.3	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	0.3	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.4	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.4	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.4	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0044217	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.8	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.2	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	0.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0001741	XY body(GO:0001741)
0.0	0.2	GO:0046930	pore complex(GO:0046930)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)
0.0	0.0	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.3	GO:0098636	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	0.1	GO:0030677	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.1	GO:0032039	integrator complex(GO:0032039)
0.0	0.1	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.2	0.5	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.4	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.6	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1	0.3	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1	0.3	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.1	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	0.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	0.4	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1	0.3	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.5	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	1.4	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.5	GO:0005522	profilin binding(GO:0005522)
0.1	0.2	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1	0.2	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1	0.2	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.1	0.3	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.1	0.2	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.3	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.3	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.2	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.2	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.2	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.2	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.3	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.2	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.4	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.2	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.2	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.2	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.4	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.0	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.0	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.2	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.1	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.3	GO:0043499	obsolete eukaryotic cell surface binding(GO:0043499)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0032395	MHC class II receptor activity(GO:0032395)
0.0	0.3	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.3	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0032405	MutLalpha complex binding(GO:0032405)
0.0	0.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.0	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0046970	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.2	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.2	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.0	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.4	GO:0101005	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.1	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0008967	phosphoglycolate phosphatase activity(GO:0008967)
0.0	0.0	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0015166	polyol transmembrane transporter activity(GO:0015166)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.0	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0004977	melanocortin receptor activity(GO:0004977)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.5	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	2.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.4	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.3	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.4	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.8	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.5	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.3	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.0	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.4	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.0	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.2	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	0.0	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	0.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.3	PID RHOA PATHWAY	RhoA signaling pathway
0.0	0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.2	PID IL23 PATHWAY	IL23-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	0.1	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1	0.8	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	1.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.2	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.4	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.4	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.3	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.4	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.1	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.2	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.6	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.3	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.2	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.4	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.3	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.0	0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.0	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.0	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	1.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.1	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.2	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus