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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RBPJ

Z-value: 0.45

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Transcription factors associated with RBPJ

Gene Symbol Gene ID Gene Info
RBPJ
ENSG00000168214.16 RBPJ

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
RBPJchr4_26321348_263225612310.964158-0.703.6e-02Click!
RBPJchr4_26208180_26208331431780.209272-0.646.2e-02Click!
RBPJchr4_26095849_26096000691530.1335670.637.1e-02Click!
RBPJchr4_26301131_26301282200780.283044-0.627.3e-02Click!
RBPJchr4_26325438_2632558910210.699475-0.618.1e-02Click!

Activity of the RBPJ motif across conditions

Conditions sorted by the z-value of the RBPJ motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_119953003_119953290 0.19 TRIM29
 tripartite motif containing 29
 38462
 0.18
chr11_119954900_119955051 0.12 TRIM29
 tripartite motif containing 29
 36633
 0.19
chr11_119954548_119954699 0.12 TRIM29
 tripartite motif containing 29
 36985
 0.19
chr5_63461313_63462499 0.09 RNF180
 ring finger protein 180
 83
 0.99
chr2_54682726_54683239 0.08 SPTBN1
 spectrin, beta, non-erythrocytic 1
 440
 0.88
chr7_99128907_99129569 0.08 FAM200A
 family with sequence similarity 200, member A
 20519
 0.09
chr6_27205685_27206711 0.07 PRSS16
 protease, serine, 16 (thymus)
 9282
 0.19
chrX_84499187_84500398 0.07 ZNF711
 zinc finger protein 711
 21
 0.94
chr19_10218994_10219145 0.06 ENSG00000209645
 .
 742
 0.32
chr9_96108355_96109117 0.06 C9orf129
 chromosome 9 open reading frame 129
 40
 0.98
chr18_7116438_7116788 0.06 LAMA1
 laminin, alpha 1
 1200
 0.55
chr21_46875019_46875466 0.06 COL18A1
 collagen, type XVIII, alpha 1
 161
 0.95
chr19_9524094_9524245 0.06 ZNF266
 zinc finger protein 266
 5588
 0.18
chr13_78493097_78493683 0.06 EDNRB
 endothelin receptor type B
 424
 0.48
chr4_17618154_17618319 0.06 MED28
 mediator complex subunit 28
 1982
 0.25
chr3_64672065_64672629 0.06 ADAMTS9
 ADAM metallopeptidase with thrombospondin type 1 motif, 9
 1008
 0.5
chrX_130036036_130037401 0.06 ENOX2
 ecto-NOX disulfide-thiol exchanger 2
 460
 0.9
chr19_12502733_12502884 0.06 CTD-3105H18.4
8307
 0.12
chr3_140769768_140770253 0.06 SPSB4
 splA/ryanodine receptor domain and SOCS box containing 4
 234
 0.95
chr4_176922498_176923243 0.06 GPM6A
 glycoprotein M6A
 613
 0.78
chr3_71586010_71586190 0.06 ENSG00000221264
 .
 5140
 0.23
chr21_46530236_46530387 0.06 PRED58
4562
 0.17
chr2_105275388_105275738 0.05 ENSG00000207249
 .
 74129
 0.1
chr21_35897414_35897754 0.05 RCAN1
 regulator of calcineurin 1
 102
 0.97
chr6_41605286_41606011 0.05 MDFI
 MyoD family inhibitor
 528
 0.74
chr8_145689855_145691101 0.05 CYHR1
 cysteine/histidine-rich 1
 60
 0.88
chr1_234041439_234041955 0.05 SLC35F3
 solute carrier family 35, member F3
 1018
 0.65
chr12_122460681_122461523 0.05 BCL7A
 B-cell CLL/lymphoma 7A
 1310
 0.49
chr2_159825200_159826543 0.05 TANC1
 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
 688
 0.73
chr2_177392551_177392702 0.05 ENSG00000252027
 .
 136778
 0.04
chr1_173175995_173176483 0.05 TNFSF4
 tumor necrosis factor (ligand) superfamily, member 4
 213
 0.96
chr4_30718989_30719310 0.05 PCDH7
 protocadherin 7
 2888
 0.4
chr8_146156057_146156445 0.05 ZNF16
 zinc finger protein 16
 19730
 0.14
chr4_118904778_118905073 0.05 NDST3
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
 50575
 0.19
chr19_11891380_11891531 0.05 ZNF441
 zinc finger protein 441
 13548
 0.11
chr9_8718682_8718836 0.05 PTPRD
 protein tyrosine phosphatase, receptor type, D
 15135
 0.22
chr16_31438814_31439148 0.05 COX6A2
 cytochrome c oxidase subunit VIa polypeptide 2
 768
 0.46
chr14_104582609_104583337 0.05 ENSG00000207568
 .
 769
 0.59
chr6_24779816_24779967 0.05 GMNN
 geminin, DNA replication inhibitor
 2797
 0.21
chr6_72129322_72130506 0.05 ENSG00000207827
 .
 16590
 0.22
chr16_3273990_3274238 0.05 ZNF200
 zinc finger protein 200
 10956
 0.1
chr4_57973648_57973950 0.05 ENSG00000238541
 .
 1288
 0.36
chr18_25754690_25754841 0.05 CDH2
 cadherin 2, type 1, N-cadherin (neuronal)
 2645
 0.44
chr19_58132756_58132907 0.05 ZNF134
 zinc finger protein 134
 7207
 0.1
chrX_47272886_47273037 0.05 ENSG00000221459
 .
 24913
 0.14
chr13_24607852_24608071 0.05 SPATA13
 spermatogenesis associated 13
 54017
 0.13
chr19_12637235_12637523 0.05 CTD-2192J16.21
6408
 0.12
chr20_2260809_2260960 0.05 TGM3
 transglutaminase 3
 15763
 0.23
chr3_133710186_133710337 0.05 SLCO2A1
 solute carrier organic anion transporter family, member 2A1
 38497
 0.17
chr22_20119477_20120671 0.05 ZDHHC8
 zinc finger, DHHC-type containing 8
 603
 0.53
chr9_128652555_128652706 0.05 PBX3
 pre-B-cell leukemia homeobox 3
 25080
 0.27
chr2_182675706_182676117 0.04 ENSG00000221023
 .
 72578
 0.09
chr1_223351484_223351635 0.04 TLR5
 toll-like receptor 5
 34935
 0.22
chr16_69140450_69141374 0.04 HAS3
 hyaluronan synthase 3
 400
 0.81
chr17_5086107_5086258 0.04 ZNF594
 zinc finger protein 594
 1510
 0.3
chr18_908458_909079 0.04 RP11-672L10.3
1087
 0.42
chr2_28565345_28565858 0.04 AC093690.1
32275
 0.15
chr12_122884907_122885085 0.04 CLIP1
 CAP-GLY domain containing linker protein 1
 435
 0.86
chr4_11652300_11652527 0.04 HS3ST1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
 221024
 0.02
chr19_58050211_58050362 0.04 ZNF550
 zinc finger protein 550
 9075
 0.1
chr19_12256353_12256531 0.04 ZNF625
 zinc finger protein 625
 2175
 0.18
chr4_187648163_187648374 0.04 FAT1
 FAT atypical cadherin 1
 392
 0.92
chr6_79902044_79902327 0.04 HMGN3-AS1
 HMGN3 antisense RNA 1
 41250
 0.16
chr4_186130212_186131033 0.04 KIAA1430
 KIAA1430
 36
 0.92
chr18_21198891_21199952 0.04 ANKRD29
 ankyrin repeat domain 29
 30065
 0.14
chr10_25836306_25836457 0.04 ENSG00000222543
 .
 153608
 0.04
chr10_115860454_115861476 0.04 ENSG00000253066
 .
 10208
 0.2
chr12_133780930_133781187 0.04 AC226150.4
 Uncharacterized protein
 6714
 0.13
chr11_66153976_66154134 0.04 ENSG00000202317
 .
 6865
 0.08
chr11_119953470_119953621 0.04 TRIM29
 tripartite motif containing 29
 38063
 0.18
chr11_8615266_8616201 0.04 STK33
 serine/threonine kinase 33
 26
 0.97
chr2_105475725_105475876 0.04 POU3F3
 POU class 3 homeobox 3
 3831
 0.16
chr10_72217935_72218559 0.04 NODAL
 nodal growth differentiation factor
 10540
 0.17
chr13_88329839_88330831 0.04 SLITRK5
 SLIT and NTRK-like family, member 5
 4837
 0.33
chr3_46263422_46263573 0.04 CCR1
 chemokine (C-C motif) receptor 1
 13610
 0.2
chr19_58774047_58774198 0.04 CTD-3138B18.6
3879
 0.12
chr19_46572119_46572325 0.04 IGFL4
 IGF-like family member 4
 8130
 0.15
chr19_58265433_58265584 0.04 ZNF776
 zinc finger protein 776
 3336
 0.12
chrX_19140154_19140583 0.04 GPR64
 G protein-coupled receptor 64
 211
 0.97
chr5_180277181_180277332 0.04 ZFP62
 ZFP62 zinc finger protein
 10407
 0.16
chr19_460012_460518 0.04 SHC2
 SHC (Src homology 2 domain containing) transforming protein 2
 731
 0.5
chr5_68788670_68789791 0.04 OCLN
 occludin
 612
 0.62
chr13_20175736_20176974 0.04 MPHOSPH8
 M-phase phosphoprotein 8
 31433
 0.18
chr1_218672576_218672996 0.04 C1orf143
 chromosome 1 open reading frame 143
 10652
 0.26
chr19_52469059_52469210 0.04 ZNF350
 zinc finger protein 350
 8972
 0.12
chr19_58945059_58945210 0.04 ZNF132
 zinc finger protein 132
 6455
 0.08
chr12_120142120_120142271 0.04 RP1-127H14.3
 Uncharacterized protein
 4622
 0.19
chr8_61193398_61193986 0.04 CA8
 carbonic anhydrase VIII
 279
 0.95
chr19_12016806_12016962 0.04 ZNF69
 zinc finger protein 69
 18214
 0.1
chr2_145210039_145210510 0.04 ZEB2
 zinc finger E-box binding homeobox 2
 22137
 0.25
chr19_11833281_11833438 0.04 CTC-499B15.6
8239
 0.13
chr12_32135997_32136148 0.04 KIAA1551
 KIAA1551
 20649
 0.22
chr18_64307786_64307937 0.04 ENSG00000221536
 .
 12877
 0.26
chr1_178063691_178064117 0.04 RASAL2
 RAS protein activator like 2
 628
 0.84
chr21_48087065_48088237 0.04 PRMT2
 protein arginine methyltransferase 2
 23396
 0.22
chr19_58773538_58773689 0.04 CTD-3138B18.6
4388
 0.11
chr7_5634981_5635198 0.04 FSCN1
 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
 772
 0.6
chr21_16424202_16424355 0.04 NRIP1
 nuclear receptor interacting protein 1
 12848
 0.26
chr7_93519153_93519436 0.04 TFPI2
 tissue factor pathway inhibitor 2
 188
 0.88
chr5_123985243_123985413 0.04 RP11-436H11.2
79196
 0.08
chr2_153325586_153326000 0.04 FMNL2
 formin-like 2
 134042
 0.05
chr9_99521835_99521986 0.04 ZNF510
 zinc finger protein 510
 18418
 0.24
chr6_72206174_72206487 0.03 ENSG00000212099
 .
 42349
 0.17
chr2_232479090_232479920 0.03 C2orf57
 chromosome 2 open reading frame 57
 21930
 0.15
chr12_133779073_133779476 0.03 AC226150.4
 Uncharacterized protein
 8498
 0.13
chr19_58689540_58689691 0.03 ZNF274
 zinc finger protein 274
 4781
 0.15
chr10_60273912_60274168 0.03 BICC1
 bicaudal C homolog 1 (Drosophila)
 1140
 0.65
chr12_102225232_102225392 0.03 GNPTAB
 N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
 596
 0.63
chr2_103235205_103235939 0.03 SLC9A2
 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
 594
 0.82
chr2_121103939_121104858 0.03 INHBB
 inhibin, beta B
 679
 0.78
chr13_45146605_45146867 0.03 TSC22D1
 TSC22 domain family, member 1
 3656
 0.33
chr19_2933699_2933850 0.03 AC006277.2
6969
 0.12
chr10_18655851_18656002 0.03 CACNB2
 calcium channel, voltage-dependent, beta 2 subunit
 26260
 0.24
chr12_13492233_13492384 0.03 C12orf36
 chromosome 12 open reading frame 36
 37056
 0.18
chr16_74734045_74735115 0.03 MLKL
 mixed lineage kinase domain-like
 108
 0.97
chr19_11892320_11892471 0.03 ZNF441
 zinc finger protein 441
 14488
 0.11
chr16_72459537_72459688 0.03 ENSG00000207514
 .
 49009
 0.17
chr2_48476024_48476175 0.03 ENSG00000201010
 .
 31385
 0.2
chr13_107572015_107572438 0.03 ENSG00000239050
 .
 55148
 0.17
chr15_83679247_83679398 0.03 C15orf40
 chromosome 15 open reading frame 40
 1015
 0.36
chr1_224686385_224686769 0.03 WDR26
 WD repeat domain 26
 61842
 0.11
chr3_141131899_141132175 0.03 ZBTB38
 zinc finger and BTB domain containing 38
 10377
 0.23
chr1_81137188_81137522 0.03 ENSG00000266033
 .
 342182
 0.01
chr19_9639561_9639712 0.03 ZNF426
 zinc finger protein 426
 7609
 0.17
chr16_3432968_3433133 0.03 MTRNR2L4
 MT-RNR2-like 4
 10767
 0.11
chr5_4082877_4083178 0.03 CTD-2012M11.3
482725
 0.01
chr19_44514850_44515001 0.03 ZNF230
 zinc finger protein 230
 4073
 0.12
chr5_149524115_149524266 0.03 PDGFRB
 platelet-derived growth factor receptor, beta polypeptide
 7190
 0.15
chr3_158508847_158509075 0.03 RP11-379F4.8
8625
 0.16
chr5_180278006_180278157 0.03 ZFP62
 ZFP62 zinc finger protein
 9582
 0.17
chr3_119030384_119030661 0.03 ARHGAP31-AS1
 ARHGAP31 antisense RNA 1
 11085
 0.16
chr9_110013679_110013830 0.03 RAD23B
 RAD23 homolog B (S. cerevisiae)
 31664
 0.23
chr17_5085116_5085307 0.03 ZNF594
 zinc finger protein 594
 2481
 0.2
chr5_159797706_159797884 0.03 C1QTNF2
 C1q and tumor necrosis factor related protein 2
 147
 0.95
chr6_10586335_10586486 0.03 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
 431
 0.84
chr10_98455004_98455155 0.03 PIK3AP1
 phosphoinositide-3-kinase adaptor protein 1
 25192
 0.18
chr5_58958074_58958460 0.03 ENSG00000202601
 .
 41262
 0.2
chr15_75339241_75339413 0.03 PPCDC
 phosphopantothenoylcysteine decarboxylase
 3711
 0.2
chr11_12063788_12063939 0.03 DKK3
 dickkopf WNT signaling pathway inhibitor 3
 32547
 0.2
chr7_41740779_41741576 0.03 INHBA
 inhibin, beta A
 970
 0.56
chr1_236046770_236047092 0.03 LYST
 lysosomal trafficking regulator
 59
 0.97
chr5_124079913_124080218 0.03 ZNF608
 zinc finger protein 608
 149
 0.94
chr17_47987589_47988019 0.03 ENSG00000199492
 .
 55736
 0.08
chr17_60885608_60885921 0.03 MARCH10
 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
 59
 0.98
chr10_91274995_91275346 0.03 SLC16A12
 solute carrier family 16, member 12
 20143
 0.18
chr16_3108546_3109349 0.03 RP11-473M20.7
139
 0.86
chr1_21900562_21900713 0.03 ALPL
 alkaline phosphatase, liver/bone/kidney
 334
 0.87
chr5_9544908_9545592 0.03 SEMA5A
 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
 937
 0.56
chr8_21914018_21914169 0.03 DMTN
 dematin actin binding protein
 323
 0.82
chr6_15297900_15298051 0.03 ENSG00000201367
 .
 17176
 0.18
chr15_58767167_58767318 0.03 ALDH1A2
 aldehyde dehydrogenase 1 family, member A2
 1130
 0.49
chr11_47586558_47587254 0.03 PTPMT1
 protein tyrosine phosphatase, mitochondrial 1
 76
 0.59
chr1_205343234_205343399 0.03 LEMD1-AS1
 LEMD1 antisense RNA 1
 936
 0.53
chr4_156681206_156681472 0.03 GUCY1B3
 guanylate cyclase 1, soluble, beta 3
 728
 0.72
chr9_34047108_34047259 0.03 UBAP2
 ubiquitin associated protein 2
 1700
 0.27
chr21_36594684_36594936 0.03 RUNX1
 runt-related transcription factor 1
 173169
 0.04
chr19_2933350_2933631 0.03 AC006277.2
6685
 0.12
chr7_50321625_50321823 0.03 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 22600
 0.25
chr4_70108820_70108971 0.03 UGT2B11
 UDP glucuronosyltransferase 2 family, polypeptide B11
 28446
 0.16
chr19_58772914_58773185 0.03 CTD-3138B18.6
4952
 0.11
chr8_1993393_1993636 0.03 MYOM2
 myomesin 2
 330
 0.93
chr19_58370756_58370907 0.03 ZNF587
 zinc finger protein 587
 3494
 0.13
chr18_42044646_42044797 0.03 SETBP1
 SET binding protein 1
 215417
 0.02
chr19_20117293_20117444 0.03 ZNF682
 zinc finger protein 682
 703
 0.66
chr19_38229308_38229579 0.03 ZNF607
 zinc finger protein 607
 18752
 0.15
chr6_142699302_142699594 0.03 GPR126
 G protein-coupled receptor 126
 12001
 0.29
chr19_35448920_35449083 0.03 ZNF792
 zinc finger protein 792
 2606
 0.2
chr14_65184455_65184704 0.03 PLEKHG3
 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
 2158
 0.36
chr19_12541727_12541878 0.03 CTD-3105H18.16
 Uncharacterized protein
 10094
 0.11
chr6_28504701_28505374 0.03 GPX5
 glutathione peroxidase 5 (epididymal androgen-related protein)
 11248
 0.17
chr9_124414074_124414751 0.03 DAB2IP
 DAB2 interacting protein
 539
 0.84
chr4_149137803_149137954 0.03 RP11-76G10.1
70256
 0.13
chr1_15251371_15251898 0.03 KAZN
 kazrin, periplakin interacting protein
 1008
 0.7
chrX_19687578_19687729 0.03 SH3KBP1
 SH3-domain kinase binding protein 1
 827
 0.76
chr6_7469002_7469180 0.03 RP3-512B11.3
72480
 0.09
chr5_80716043_80716194 0.03 ACOT12
 acyl-CoA thioesterase 12
 26120
 0.23
chr3_14853690_14853962 0.03 FGD5
 FYVE, RhoGEF and PH domain containing 5
 6643
 0.24
chr15_62402344_62402495 0.03 C2CD4A
 C2 calcium-dependent domain containing 4A
 43243
 0.13
chr10_95333061_95333288 0.03 FFAR4
 free fatty acid receptor 4
 6735
 0.17
chr1_247201400_247201551 0.03 ZNF695
 zinc finger protein 695
 30080
 0.15
chr2_144499859_144500010 0.03 RP11-434H14.1
1071
 0.59
chr4_184826206_184826847 0.03 STOX2
 storkhead box 2
 17
 0.99
chr2_95880533_95880684 0.03 ZNF2
 zinc finger protein 2
 49046
 0.12
chr6_113953461_113953992 0.03 ENSG00000266650
 .
 29609
 0.21
chr5_92924582_92924758 0.03 ENSG00000237187
 .
 3316
 0.26
chr16_72882732_72883241 0.03 ENSG00000251868
 .
 27095
 0.17
chr6_90796198_90796349 0.03 ENSG00000222078
 .
 85048
 0.09
chr14_74222749_74222900 0.03 ELMSAN1
 ELM2 and Myb/SANT-like domain containing 1
 1105
 0.36
chr12_49392080_49393040 0.03 RP11-386G11.5
379
 0.49
chr2_220251514_220252585 0.03 DNPEP
 aspartyl aminopeptidase
 19
 0.94
chr19_58861430_58861581 0.03 A1BG-AS1
 A1BG antisense RNA 1
 1831
 0.13
chr9_112889621_112889772 0.03 AKAP2
 A kinase (PRKA) anchor protein 2
 1915
 0.45
chr7_36195246_36195841 0.03 EEPD1
 endonuclease/exonuclease/phosphatase family domain containing 1
 2666
 0.32
chr4_139941093_139941244 0.03 ENSG00000264953
 .
 2435
 0.22
chr9_12775957_12776199 0.03 LURAP1L
 leucine rich adaptor protein 1-like
 1058
 0.54
chr20_55363223_55363386 0.03 ENSG00000207158
 .
 2161
 0.37
chr5_159738704_159739455 0.03 CCNJL
 cyclin J-like
 404
 0.84
chr10_110225810_110226152 0.03 ENSG00000222436
 .
 475087
 0.01
chr9_129467466_129467647 0.03 ENSG00000266403
 .
 13056
 0.21
chr1_15575745_15575896 0.03 FHAD1
 forkhead-associated (FHA) phosphopeptide binding domain 1
 2044
 0.36

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of RBPJ

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.0 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)