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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RELA

Z-value: 0.63

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Transcription factors associated with RELA

Gene Symbol	Gene ID	Gene Info
RELA Ensembl NCBI GeneCards UniProt	ENSG00000173039.14	RELA

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
RELA	chr11_65429318_65430091	195	0.869044	-0.42	2.6e-01	Click!
RELA	chr11_65430100_65430433	2	0.946657	-0.23	5.5e-01	Click!
RELA	chr11_65430663_65431111	322	0.764562	-0.18	6.5e-01	Click!
RELA	chr11_65431137_65431406	706	0.461078	0.07	8.7e-01	Click!

Activity of the RELA motif across conditions

Conditions sorted by the z-value of the RELA motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_8000859_8001010	0.47	TNFRSF9	tumor necrosis factor receptor superfamily, member 9	8	0.98
chr22_30475055_30475206	0.32	HORMAD2	HORMA domain containing 2	1033	0.38
chrX_40429955_40430133	0.30	ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	10102	0.21
chr20_4795121_4795462	0.26	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	478	0.82
chr12_42958835_42958986	0.24	PRICKLE1	prickle homolog 1 (Drosophila)	24568	0.21
chr14_94425760_94425911	0.24	ASB2	ankyrin repeat and SOCS box containing 2	2068	0.26
chr7_128578118_128579002	0.22	IRF5	interferon regulatory factor 5	289	0.89
chr6_20202498_20202689	0.22	RP11-239H6.2		9725	0.23
chr15_69083910_69084061	0.22	ENSG00000265195	.	10279	0.23
chr4_100738641_100738957	0.21	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	796	0.72
chrX_53741093_53741244	0.21	HUWE1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	27495	0.23
chr20_5296763_5297139	0.21	PROKR2	prokineticin receptor 2	427	0.87
chr10_65021596_65021747	0.21	JMJD1C	jumonji domain containing 1C	7155	0.29
chr2_38265076_38265999	0.21	RMDN2-AS1	RMDN2 antisense RNA 1	2053	0.33
chr2_214108249_214108400	0.21	SPAG16	sperm associated antigen 16	40789	0.21
chr20_50141923_50142074	0.21	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	17260	0.25
chr17_47572677_47573321	0.20	NGFR	nerve growth factor receptor	344	0.86
chr3_71833354_71833608	0.19	PROK2	prokineticin 2	731	0.68
chr2_113932280_113932569	0.19	AC016683.5		490	0.59
chr14_66694537_66694688	0.18	ENSG00000200860	.	50259	0.19
chr5_150473764_150473973	0.18	TNIP1	TNFAIP3 interacting protein 1	730	0.68
chr8_126964027_126964178	0.18	ENSG00000206695	.	50907	0.19
chr9_123690633_123691433	0.18	TRAF1	TNF receptor-associated factor 1	14	0.98
chrX_9979270_9979421	0.18	WWC3	WWC family member 3	4257	0.22
chr5_49962630_49963750	0.18	PARP8	poly (ADP-ribose) polymerase family, member 8	201	0.97
chr2_219745053_219745526	0.18	WNT10A	wingless-type MMTV integration site family, member 10A	204	0.9
chr15_45409056_45409207	0.17	DUOX2	dual oxidase 2	2589	0.14
chr13_46739755_46739906	0.17	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	2824	0.22
chr1_9688741_9688898	0.17	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	22971	0.15
chr6_138028959_138029110	0.17	ENSG00000216097	.	9051	0.27
chr3_142800787_142800938	0.17	CHST2	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	37311	0.15
chr15_31638589_31638828	0.17	KLF13	Kruppel-like factor 13	6572	0.32
chr16_28996496_28996848	0.16	LAT	linker for activation of T cells	11	0.94
chr2_164608573_164608724	0.16	FIGN	fidgetin	16126	0.31
chr17_72735282_72735631	0.16	RAB37	RAB37, member RAS oncogene family	2085	0.18
chr14_22994691_22994955	0.16	TRAJ15	T cell receptor alpha joining 15	3757	0.14
chr7_30766706_30766866	0.16	INMT	indolethylamine N-methyltransferase	24965	0.16
chr4_105982370_105982725	0.16	ENSG00000252136	.	44597	0.16
chr12_62996165_62996975	0.16	RP11-631N16.2		38	0.9
chr1_112159044_112159195	0.16	RAP1A	RAP1A, member of RAS oncogene family	3280	0.23
chr2_10548224_10548465	0.16	HPCAL1	hippocalcin-like 1	11803	0.19
chr19_54672117_54672268	0.16	TMC4	transmembrane channel-like 4	4255	0.08
chr2_10169297_10169448	0.16	KLF11	Kruppel-like factor 11	13604	0.13
chr19_45271245_45271464	0.15	ENSG00000253027	.	3147	0.15
chr1_93443435_93443586	0.15	ENSG00000239710	.	2830	0.16
chr3_195913428_195913625	0.15	ENSG00000222335	.	15694	0.13
chr16_68798920_68799109	0.15	ENSG00000200558	.	22631	0.14
chr5_1105065_1105874	0.15	SLC12A7	solute carrier family 12 (potassium/chloride transporter), member 7	6681	0.19
chr8_37751638_37751789	0.15	RAB11FIP1	RAB11 family interacting protein 1 (class I)	5259	0.15
chr15_31555832_31555983	0.15	KLF13	Kruppel-like factor 13	63151	0.13
chr9_123688442_123688941	0.15	TRAF1	TNF receptor-associated factor 1	2356	0.33
chr9_139927070_139927409	0.14	FUT7	fucosyltransferase 7 (alpha (1,3) fucosyltransferase)	223	0.78
chr6_3876229_3876380	0.14	FAM50B	family with sequence similarity 50, member B	26682	0.18
chr13_74807358_74807666	0.14	ENSG00000206617	.	55839	0.16
chr17_46187551_46187761	0.14	SNX11	sorting nexin 11	1655	0.23
chr17_38024211_38024362	0.14	ZPBP2	zona pellucida binding protein 2	131	0.95
chr17_66286056_66286766	0.14	SLC16A6	solute carrier family 16, member 6	846	0.47
chr16_89690039_89690304	0.14	DPEP1	dipeptidase 1 (renal)	3171	0.14
chrX_123373984_123374135	0.14	ENSG00000252693	.	42466	0.19
chr10_90753077_90753312	0.14	ACTA2	actin, alpha 2, smooth muscle, aorta	2047	0.24
chr7_36640832_36640983	0.14	AOAH-IT1	AOAH intronic transcript 1 (non-protein coding)	1181	0.5
chr1_150737104_150737638	0.14	CTSS	cathepsin S	897	0.5
chr21_30464791_30465071	0.13	MAP3K7CL	MAP3K7 C-terminal like	356	0.83
chr5_134879321_134879990	0.13	NEUROG1	neurogenin 1	8016	0.18
chr1_147229260_147229411	0.13	RP11-433J22.2		91	0.97
chr3_131105945_131106096	0.13	NUDT16	nudix (nucleoside diphosphate linked moiety X)-type motif 16	5391	0.18
chr20_34674700_34674851	0.13	EPB41L1	erythrocyte membrane protein band 4.1-like 1	4651	0.22
chr15_86127194_86127729	0.13	RP11-815J21.2		4052	0.21
chr11_121323015_121324255	0.13	RP11-730K11.1		7	0.95
chr21_40275169_40275320	0.13	ENSG00000272015	.	8535	0.29
chr1_31227757_31227908	0.13	LAPTM5	lysosomal protein transmembrane 5	2835	0.23
chr1_199997854_199998005	0.13	NR5A2	nuclear receptor subfamily 5, group A, member 2	918	0.55
chr14_90798758_90798909	0.13	NRDE2	NRDE-2, necessary for RNA interference, domain containing	352	0.89
chr7_74057672_74058172	0.13	GTF2I	general transcription factor IIi	14089	0.22
chr1_166459489_166459697	0.13	FAM78B	family with sequence similarity 78, member B	323387	0.01
chr9_134143747_134144006	0.13	FAM78A	family with sequence similarity 78, member A	2004	0.31
chr12_120679359_120679510	0.12	PXN	paxillin	8530	0.12
chrX_128915626_128915992	0.12	SASH3	SAM and SH3 domain containing 3	1849	0.35
chr11_27435035_27435186	0.12	CCDC34	coiled-coil domain containing 34	49695	0.12
chr17_38480138_38480579	0.12	RARA	retinoic acid receptor, alpha	5821	0.12
chr14_77499378_77500437	0.12	IRF2BPL	interferon regulatory factor 2 binding protein-like	4873	0.22
chr11_114217713_114217864	0.12	RP11-64D24.2		9505	0.18
chr15_81586254_81586487	0.12	IL16	interleukin 16	2884	0.28
chr20_47441337_47441845	0.12	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	2829	0.36
chr10_6243545_6244657	0.12	RP11-414H17.5		555	0.52
chr12_22695256_22695407	0.12	C2CD5	C2 calcium-dependent domain containing 5	1856	0.46
chrX_48793999_48794379	0.12	PIM2	pim-2 oncogene	17888	0.08
chrX_41301243_41301541	0.12	NYX	nyctalopin	5295	0.25
chr7_26333293_26333815	0.11	SNX10	sorting nexin 10	880	0.67
chr1_65430726_65432146	0.11	JAK1	Janus kinase 1	751	0.73
chr6_106808594_106809355	0.11	RP11-404H14.1		1382	0.42
chr9_134604865_134605016	0.11	ENSG00000240853	.	4086	0.24
chr8_144512945_144513817	0.11	MAFA	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	805	0.48
chr21_39867301_39867487	0.11	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	2951	0.4
chr4_17809379_17809707	0.11	DCAF16	DDB1 and CUL4 associated factor 16	2838	0.25
chr6_1014051_1014202	0.11	AL033381.1	Uncharacterized protein; cDNA FLJ34594 fis, clone KIDNE2009109	66038	0.14
chr22_42815517_42815668	0.11	NFAM1	NFAT activating protein with ITAM motif 1	12809	0.19
chr6_132113440_132113591	0.11	ENSG00000266807	.	203	0.94
chr9_132650035_132650502	0.11	FNBP1	formin binding protein 1	31321	0.13
chr3_16156075_16156226	0.11	GALNT15	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15	60006	0.14
chr15_41234314_41234975	0.11	CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)	10516	0.12
chr2_33537454_33537605	0.11	LTBP1	latent transforming growth factor beta binding protein 1	10932	0.2
chr10_3848477_3848747	0.11	KLF6	Kruppel-like factor 6	21139	0.22
chr18_59519452_59519603	0.11	RNF152	ring finger protein 152	41465	0.22
chr17_67322489_67323211	0.11	ABCA5	ATP-binding cassette, sub-family A (ABC1), member 5	381	0.89
chr11_69457554_69457705	0.11	CCND1	cyclin D1	1655	0.41
chr1_226922169_226922483	0.11	ITPKB	inositol-trisphosphate 3-kinase B	2833	0.32
chr12_111842372_111842523	0.11	SH2B3	SH2B adaptor protein 3	1305	0.45
chr1_37945353_37945703	0.11	ZC3H12A	zinc finger CCCH-type containing 12A	1763	0.28
chr19_50400390_50400724	0.11	IL4I1	interleukin 4 induced 1	345	0.67
chr1_143743180_143744039	0.11	RP6-206I17.4		23905	0.15
chr6_72155810_72156092	0.11	ENSG00000207827	.	42627	0.16
chr12_111115977_111116128	0.11	HVCN1	hydrogen voltage-gated channel 1	10462	0.16
chr15_42349005_42349667	0.11	PLA2G4E	phospholipase A2, group IVE	5948	0.18
chr18_59619511_59619683	0.10	RNF152	ring finger protein 152	58133	0.16
chr19_10341031_10341948	0.10	ENSG00000264266	.	400	0.34
chr15_91807157_91807528	0.10	SV2B	synaptic vesicle glycoprotein 2B	38242	0.2
chr8_142138821_142140144	0.10	RP11-809O17.1		578	0.46
chr2_219744680_219744914	0.10	WNT10A	wingless-type MMTV integration site family, member 10A	288	0.85
chr22_22005684_22006266	0.10	ENSG00000212102	.	1295	0.23
chr8_59717634_59717850	0.10	ENSG00000201231	.	9369	0.29
chr6_37592383_37592534	0.10	MDGA1	MAM domain containing glycosylphosphatidylinositol anchor 1	21692	0.22
chr17_56230401_56230552	0.10	OR4D1	olfactory receptor, family 4, subfamily D, member 1	2018	0.26
chr6_75458992_75459143	0.10	ENSG00000264884	.	29508	0.26
chr17_7152312_7152463	0.10	CTDNEP1	CTD nuclear envelope phosphatase 1	1729	0.12
chr10_91093714_91093865	0.10	IFIT3	interferon-induced protein with tetratricopeptide repeats 3	1548	0.3
chr7_139930052_139930405	0.10	ENSG00000199283	.	11442	0.17
chr18_42306038_42306201	0.10	SETBP1	SET binding protein 1	28990	0.26
chr12_56881156_56881307	0.10	GLS2	glutaminase 2 (liver, mitochondrial)	671	0.58
chr14_93427433_93427584	0.10	CHGA	chromogranin A (parathyroid secretory protein 1)	37987	0.18
chr1_154300198_154300512	0.10	ATP8B2	ATPase, aminophospholipid transporter, class I, type 8B, member 2	79	0.94
chr19_1074414_1074782	0.10	HMHA1	histocompatibility (minor) HA-1	2844	0.13
chr18_72912801_72912952	0.10	ZADH2	zinc binding alcohol dehydrogenase domain containing 2	4592	0.28
chr19_46283149_46283300	0.10	DMPK	dystrophia myotonica-protein kinase	575	0.52
chr1_247354543_247354824	0.10	MIR3916	microRNA 3916	8815	0.14
chr9_92218215_92218814	0.10	GADD45G	growth arrest and DNA-damage-inducible, gamma	1414	0.56
chr21_45564255_45564539	0.10	C21orf33	chromosome 21 open reading frame 33	8396	0.15
chr20_43597999_43598419	0.10	STK4	serine/threonine kinase 4	3042	0.19
chr10_63595750_63596410	0.10	ARID5B	AT rich interactive domain 5B (MRF1-like)	64979	0.13
chr4_113205771_113206741	0.10	TIFA	TRAF-interacting protein with forkhead-associated domain	803	0.58
chr2_145116612_145116763	0.10	GTDC1	glycosyltransferase-like domain containing 1	26604	0.24
chr7_4817960_4818111	0.10	AP5Z1	adaptor-related protein complex 5, zeta 1 subunit	2771	0.22
chr1_51442471_51443647	0.10	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	7443	0.21
chr2_47796814_47797322	0.10	KCNK12	potassium channel, subfamily K, member 12	1010	0.5
chr2_106363775_106364396	0.10	NCK2	NCK adaptor protein 2	1897	0.48
chr1_167599991_167600483	0.10	RP3-455J7.4		326	0.69
chr19_38908265_38908571	0.09	RASGRP4	RAS guanyl releasing protein 4	8384	0.09
chr9_117145261_117145418	0.09	AKNA	AT-hook transcription factor	4904	0.23
chr2_192058910_192059074	0.09	STAT4	signal transducer and activator of transcription 4	42670	0.15
chr5_149461865_149462126	0.09	CSF1R	colony stimulating factor 1 receptor	3995	0.18
chr18_2656091_2657266	0.09	SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	792	0.58
chr8_28205045_28205788	0.09	ZNF395	zinc finger protein 395	3667	0.19
chr19_49839028_49839359	0.09	CD37	CD37 molecule	472	0.63
chr10_79050334_79050485	0.09	RP11-328K22.1		23290	0.23
chr22_33278140_33278291	0.09	TIMP3	TIMP metallopeptidase inhibitor 3	80528	0.1
chr20_47884918_47885071	0.09	ZNFX1	zinc finger, NFX1-type containing 1	2766	0.18
chr20_3888044_3888195	0.09	ENSG00000199024	.	10022	0.14
chr1_36816210_36816695	0.09	STK40	serine/threonine kinase 40	10489	0.13
chr2_234293590_234293937	0.09	DGKD	diacylglycerol kinase, delta 130kDa	828	0.57
chr6_144017218_144017369	0.09	PHACTR2	phosphatase and actin regulator 2	18088	0.25
chr4_152331308_152331459	0.09	FAM160A1	family with sequence similarity 160, member A1	879	0.7
chr12_806850_807001	0.09	NINJ2	ninjurin 2	33980	0.14
chr19_39106930_39107372	0.09	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	1413	0.27
chr2_201987300_201987657	0.09	CFLAR	CASP8 and FADD-like apoptosis regulator	278	0.87
chr20_1309605_1309756	0.09	SDCBP2	syndecan binding protein (syntenin) 2	203	0.91
chr6_15309152_15309303	0.09	ENSG00000201367	.	5924	0.22
chr11_71826248_71826399	0.09	ANAPC15	anaphase promoting complex subunit 15	2497	0.13
chr9_114792415_114792566	0.09	RP11-4O1.2		6100	0.22
chr17_37793084_37793352	0.09	STARD3	StAR-related lipid transfer (START) domain containing 3	100	0.94
chr1_27070439_27070710	0.09	ARID1A	AT rich interactive domain 1A (SWI-like)	14703	0.13
chr7_29283709_29283860	0.09	AC004593.3		35198	0.16
chrX_39473449_39473600	0.09	ENSG00000263730	.	46946	0.2
chrX_30594869_30596024	0.09	CXorf21	chromosome X open reading frame 21	515	0.84
chr15_45027870_45028221	0.09	TRIM69	tripartite motif containing 69	515	0.75
chr1_203259093_203259633	0.09	BTG2	BTG family, member 2	15301	0.16
chr9_37036694_37037719	0.09	PAX5	paired box 5	3103	0.27
chr7_74194192_74194343	0.09	NCF1	neutrophil cytosolic factor 1	2654	0.28
chr20_11435441_11435592	0.09	ENSG00000222281	.	364223	0.01
chr11_14468343_14468494	0.09	ENSG00000251991	.	32020	0.18
chr1_182583862_182584759	0.09	RGS16	regulator of G-protein signaling 16	10767	0.21
chr19_35940283_35940434	0.09	FFAR2	free fatty acid receptor 2	259	0.87
chr9_72725675_72725941	0.09	MAMDC2-AS1	MAMDC2 antisense RNA 1	2968	0.33
chr3_33800152_33800303	0.08	PDCD6IP	programmed cell death 6 interacting protein	39617	0.18
chrX_76776329_76776480	0.08	FGF16	fibroblast growth factor 16	66756	0.13
chr16_16119769_16119920	0.08	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	16131	0.23
chr12_70132575_70133879	0.08	RAB3IP	RAB3A interacting protein	47	0.95
chr16_3095827_3096553	0.08	MMP25	matrix metallopeptidase 25	492	0.51
chr2_28904176_28904327	0.08	ENSG00000222232	.	2591	0.25
chr20_25037809_25038550	0.08	ACSS1	acyl-CoA synthetase short-chain family member 1	639	0.73
chr9_110187375_110187686	0.08	ENSG00000263459	.	8360	0.24
chr3_9745623_9746706	0.08	CPNE9	copine family member IX	654	0.62
chr7_5183512_5184010	0.08	ZNF890P	zinc finger protein 890, pseudogene	16335	0.17
chr7_44679217_44679482	0.08	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	15288	0.18
chr15_91373266_91373417	0.08	CTD-3094K11.1		9613	0.13
chrX_48794595_48794842	0.08	PIM2	pim-2 oncogene	18417	0.08
chr20_35463892_35464165	0.08	SOGA1	suppressor of glucose, autophagy associated 1	19344	0.15
chr13_20175736_20176974	0.08	MPHOSPH8	M-phase phosphoprotein 8	31433	0.18
chr11_35325325_35325476	0.08	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	2325	0.31
chr2_43452698_43453520	0.08	ZFP36L2	ZFP36 ring finger protein-like 2	639	0.76
chr4_103421804_103422645	0.08	AF213884.2		252	0.5

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RELA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0070254	mucus secretion(GO:0070254)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.0	GO:0052167	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.0	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0055075	potassium ion homeostasis(GO:0055075)
0.0	0.0	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.0	GO:1903521	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.0	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.2	GO:0043303	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0	0.1	GO:0046475	glycerophospholipid catabolic process(GO:0046475)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.0	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.2	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	GO:0071942	XPC complex(GO:0071942)
0.2	GO:0001772	immunological synapse(GO:0001772)
0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	GO:0001740	Barr body(GO:0001740)
0.1	GO:0002102	podosome(GO:0002102)
0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	GO:0005826	actomyosin contractile ring(GO:0005826)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0048406	nerve growth factor binding(GO:0048406)
0.2	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0	GO:0019863	IgE binding(GO:0019863)
0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	GO:0034648	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1	GO:0050786	RAGE receptor binding(GO:0050786)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.6	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.2	PID CD40 PATHWAY	CD40/CD40L signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.1	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation