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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for REST

Z-value: 0.41

Motif logo

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
ENSG00000084093.11 REST

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
RESTchr4_57773669_577739222800.912776-0.551.3e-01Click!
RESTchr4_57737524_57737675364760.1245220.541.3e-01Click!
RESTchr4_57773435_577736245460.775427-0.501.7e-01Click!
RESTchr4_57775517_5777606117140.365889-0.314.1e-01Click!
RESTchr4_57737703_57737910362690.1250700.314.2e-01Click!

Activity of the REST motif across conditions

Conditions sorted by the z-value of the REST motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr21_42218839_42219216 0.31 DSCAM
Down syndrome cell adhesion molecule
38
0.99
chr3_9745623_9746706 0.28 CPNE9
copine family member IX
654
0.62
chr1_31331684_31331943 0.26 RP1-65J11.5

808
0.58
chr1_1899902_1900053 0.25 C1orf222
chromosome 1 open reading frame 222
2012
0.25
chr10_50606076_50606780 0.25 DRGX
dorsal root ganglia homeobox
2931
0.27
chr14_58332211_58332467 0.24 SLC35F4
solute carrier family 35, member F4
441
0.87
chr2_51259112_51259522 0.23 NRXN1
neurexin 1
3
0.99
chr19_10806604_10806755 0.22 QTRT1
queuine tRNA-ribosyltransferase 1
5448
0.12
chr20_33814974_33815173 0.21 MMP24
matrix metallopeptidase 24 (membrane-inserted)
616
0.6
chr1_20916301_20916452 0.20 CDA
cytidine deaminase
935
0.55
chr1_43201434_43201585 0.19 CLDN19
claudin 19
4302
0.16
chr16_2510179_2510910 0.17 C16orf59
chromosome 16 open reading frame 59
67
0.92
chr10_89419474_89420355 0.17 RP11-57C13.3

154
0.8
chr5_6687085_6687491 0.17 PAPD7
PAP associated domain containing 7
27430
0.2
chr7_948384_949423 0.17 ADAP1
ArfGAP with dual PH domains 1
4189
0.17
chr2_47798093_47798638 0.17 KCNK12
potassium channel, subfamily K, member 12
287
0.86
chr6_43252045_43252196 0.17 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
13616
0.13
chr16_30662970_30663539 0.17 PRR14
proline rich 14
743
0.43
chr15_72612091_72612308 0.16 CELF6
CUGBP, Elav-like family member 6
24
0.97
chr19_11592760_11593066 0.16 ELAVL3
ELAV like neuron-specific RNA binding protein 3
1065
0.31
chr3_131245838_131246060 0.16 RP11-517B11.4

9274
0.2
chr8_57358039_57358590 0.15 RP11-17A4.2

52
0.69
chr1_17896482_17896633 0.15 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
10491
0.26
chr8_145752569_145752720 0.15 LRRC24
leucine rich repeat containing 24
228
0.77
chr19_55728419_55728773 0.14 PTPRH
protein tyrosine phosphatase, receptor type, H
7772
0.08
chr16_89992729_89992956 0.14 TUBB3
Tubulin beta-3 chain
3068
0.14
chr1_155973189_155973340 0.14 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
3597
0.12
chr13_114540399_114540680 0.14 GAS6
growth arrest-specific 6
1522
0.45
chr5_54516767_54517029 0.13 MCIDAS
multiciliate differentiation and DNA synthesis associated cell cycle protein
6245
0.13
chr11_101453394_101453891 0.12 TRPC6
transient receptor potential cation channel, subfamily C, member 6
592
0.84
chr20_43273137_43273288 0.12 ADA
adenosine deaminase
7120
0.14
chr11_89785091_89785242 0.12 TRIM49C
tripartite motif containing 49C
20892
0.22
chr19_8305457_8305834 0.12 CTD-3020H12.4

1113
0.43
chr20_62528184_62528335 0.11 DNAJC5
DnaJ (Hsp40) homolog, subfamily C, member 5
1724
0.16
chr16_68269517_68269668 0.11 ESRP2
epithelial splicing regulatory protein 2
443
0.6
chr14_24906611_24906867 0.11 SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
3518
0.13
chr14_75926184_75926335 0.11 JDP2
Jun dimerization protein 2
27422
0.16
chr3_49169788_49170138 0.11 LAMB2
laminin, beta 2 (laminin S)
490
0.65
chr5_168727419_168727744 0.11 SLIT3
slit homolog 3 (Drosophila)
132
0.98
chr7_87258351_87258502 0.10 RUNDC3B
RUN domain containing 3B
495
0.81
chr6_36975031_36975182 0.10 FGD2
FYVE, RhoGEF and PH domain containing 2
1683
0.34
chr5_32232128_32232279 0.10 ENSG00000199731
.
2778
0.29
chr3_8783281_8783432 0.10 CAV3
caveolin 3
7804
0.14
chr22_20008729_20009650 0.10 TANGO2
transport and golgi organization 2 homolog (Drosophila)
511
0.64
chr5_162992519_162993506 0.10 MAT2B
methionine adenosyltransferase II, beta
60392
0.11
chr1_27183643_27183794 0.09 SFN
stratifin
5915
0.11
chr11_73093533_73093684 0.09 RELT
RELT tumor necrosis factor receptor
5895
0.15
chr8_142083713_142083864 0.09 DENND3
DENN/MADD domain containing 3
43589
0.14
chr8_142141679_142142152 0.09 RP11-809O17.1

1855
0.33
chr5_172659939_172660230 0.09 NKX2-5
NK2 homeobox 5
2125
0.3
chr1_27720013_27720164 0.09 GPR3
G protein-coupled receptor 3
940
0.45
chr1_109727416_109727567 0.09 ENSG00000238310
.
22979
0.13
chr11_3876946_3878257 0.08 STIM1
stromal interaction molecule 1
189
0.59
chr5_140802398_140802934 0.08 PCDHGA11
protocadherin gamma subfamily A, 11
1871
0.13
chr2_71126740_71126891 0.08 VAX2
ventral anterior homeobox 2
905
0.46
chr7_45614270_45614575 0.08 ADCY1
adenylate cyclase 1 (brain)
301
0.94
chr17_4837485_4837705 0.08 GP1BA
glycoprotein Ib (platelet), alpha polypeptide
2003
0.12
chr6_17101754_17102792 0.08 STMND1
stathmin domain containing 1
216
0.97
chr5_176921947_176922464 0.08 RP11-1334A24.6

209
0.86
chr19_574628_574849 0.08 BSG
basigin (Ok blood group)
309
0.77
chr17_45730071_45730411 0.07 KPNB1
karyopherin (importin) beta 1
1679
0.27
chr22_19566633_19566784 0.07 CLDN5
claudin 5
51640
0.11
chr2_176969688_176969839 0.07 HOXD11
homeobox D11
2251
0.13
chr22_17601345_17601496 0.07 CECR6
cat eye syndrome chromosome region, candidate 6
723
0.48
chr13_44360118_44360459 0.07 ENOX1
ecto-NOX disulfide-thiol exchanger 1
756
0.77
chr16_69345315_69346083 0.07 VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
440
0.7
chr22_50356186_50356903 0.07 PIM3
pim-3 oncogene
2383
0.28
chr7_155251163_155251329 0.07 EN2
engrailed homeobox 2
422
0.85
chr16_73024055_73024442 0.07 ENSG00000221799
.
5492
0.24
chr22_50683947_50684307 0.07 TUBGCP6
tubulin, gamma complex associated protein 6
746
0.42
chr11_125773182_125774068 0.07 PUS3
pseudouridylate synthase 3
509
0.49
chr17_78233745_78234253 0.07 RNF213
ring finger protein 213
666
0.65
chr15_80244332_80244483 0.06 BCL2A1
BCL2-related protein A1
19104
0.14
chr12_30353916_30354159 0.06 ENSG00000251781
.
105420
0.08
chr14_51561527_51561763 0.06 TRIM9
tripartite motif containing 9
149
0.96
chr3_157155512_157155783 0.06 PTX3
pentraxin 3, long
1069
0.63
chr19_8553014_8553200 0.06 HNRNPM
heterogeneous nuclear ribonucleoprotein M
2065
0.21
chr4_23890798_23891066 0.06 PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
726
0.8
chr2_36877136_36877393 0.06 FEZ2
fasciculation and elongation protein zeta 2 (zygin II)
4034
0.28
chr1_201430589_201431038 0.06 PHLDA3
pleckstrin homology-like domain, family A, member 3
7499
0.16
chr7_27275476_27275737 0.05 EVX1
even-skipped homeobox 1
6558
0.1
chr19_41168930_41169840 0.05 NUMBL
numb homolog (Drosophila)-like
19444
0.11
chr15_69222833_69223294 0.05 NOX5
NADPH oxidase, EF-hand calcium binding domain 5
90
0.69
chr5_16179066_16179217 0.05 MARCH11
membrane-associated ring finger (C3HC4) 11
743
0.56
chr6_123317343_123317959 0.05 CLVS2
clavesin 2
183
0.97
chr2_98962891_98963586 0.05 AC092675.4

220
0.79
chr3_51989723_51989962 0.05 GPR62
G protein-coupled receptor 62
512
0.56
chr1_186649228_186649406 0.05 PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
242
0.96
chr7_44529962_44530754 0.04 NUDCD3
NudC domain containing 3
121
0.96
chr14_106331520_106331671 0.04 IGHJ1
immunoglobulin heavy joining 1
73
0.4
chr16_2089839_2089990 0.04 SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
6642
0.06
chr8_22224818_22225894 0.04 SLC39A14
solute carrier family 39 (zinc transporter), member 14
305
0.9
chr17_73805350_73805708 0.04 UNK
unkempt family zinc finger
10291
0.09
chr3_120626761_120627590 0.04 STXBP5L
syntaxin binding protein 5-like
14
0.99
chr8_599967_600118 0.04 ERICH1
glutamate-rich 1
23615
0.22
chr21_46902407_46902673 0.04 COL18A1
collagen, type XVIII, alpha 1
7649
0.21
chr11_12028918_12029069 0.04 DKK3
dickkopf WNT signaling pathway inhibitor 3
1137
0.63
chr16_11295551_11295900 0.04 RMI2
RecQ mediated genome instability 2
47781
0.08
chr6_26751971_26752122 0.04 ZNF322
zinc finger protein 322
92066
0.07
chr12_71833793_71834525 0.04 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
344
0.86
chr22_50709343_50709501 0.04 MAPK11
mitogen-activated protein kinase 11
600
0.52
chr2_73518392_73518872 0.04 EGR4
early growth response 4
2197
0.23
chr3_96531977_96533205 0.04 EPHA6
EPH receptor A6
834
0.76
chr1_159906129_159906280 0.04 IGSF9
immunoglobulin superfamily, member 9
9182
0.1
chr1_33116851_33117688 0.03 RBBP4
retinoblastoma binding protein 4
181
0.89
chr4_102711575_102712644 0.03 BANK1
B-cell scaffold protein with ankyrin repeats 1
222
0.96
chr7_27282525_27283078 0.03 EVX1
even-skipped homeobox 1
186
0.53
chr2_200322083_200322803 0.03 SATB2-AS1
SATB2 antisense RNA 1
20
0.87
chr15_79382979_79383271 0.03 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
10
0.98
chr9_136738514_136738665 0.03 VAV2
vav 2 guanine nucleotide exchange factor
118814
0.05
chr19_16396913_16397119 0.03 CTD-2562J15.6

7370
0.17
chr19_40926642_40927702 0.03 SERTAD1
SERTA domain containing 1
4760
0.11
chr16_3043150_3043301 0.03 LA16c-380H5.2

11877
0.06
chr2_149401643_149402183 0.03 EPC2
enhancer of polycomb homolog 2 (Drosophila)
96
0.98
chr10_70165992_70166978 0.03 RUFY2
RUN and FYVE domain containing 2
461
0.8
chr1_206255126_206255277 0.03 ENSG00000252692
.
5892
0.18
chr17_40611024_40612223 0.03 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
536
0.62
chr16_1463725_1464471 0.03 UNKL
unkempt family zinc finger-like
594
0.51
chr13_109924709_109925156 0.03 MYO16-AS1
MYO16 antisense RNA 1
71101
0.13
chr7_27190300_27190534 0.03 HOXA-AS3
HOXA cluster antisense RNA 3
746
0.34
chr18_74779548_74779839 0.03 MBP
myelin basic protein
37524
0.2
chr11_116658098_116658624 0.03 ZNF259
zinc finger protein 259
334
0.79
chr20_56286148_56286403 0.03 PMEPA1
prostate transmembrane protein, androgen induced 1
266
0.95
chr17_32570563_32570714 0.03 CCL2
chemokine (C-C motif) ligand 2
11666
0.13
chr8_9413349_9414633 0.03 RP11-375N15.2

39
0.92
chr10_91294704_91295240 0.03 SLC16A12
solute carrier family 16, member 12
341
0.89
chr2_42990357_42990508 0.03 OXER1
oxoeicosanoid (OXE) receptor 1
969
0.61
chr19_17345728_17346858 0.03 OCEL1
occludin/ELL domain containing 1
7228
0.08
chrX_118459285_118459436 0.03 RP5-1139I1.2

68198
0.08
chr6_33558398_33558549 0.03 LINC00336
long intergenic non-protein coding RNA 336
2642
0.19
chr15_75495247_75495814 0.03 C15orf39
chromosome 15 open reading frame 39
984
0.42
chr7_132335536_132335698 0.03 AC009365.3

2064
0.31
chr7_99159760_99160460 0.02 ZNF655
zinc finger protein 655
3625
0.14
chr8_146156566_146156813 0.02 ZNF16
zinc finger protein 16
19292
0.14
chr6_52977565_52977716 0.02 RP11-506E9.3

13304
0.12
chr20_62517126_62517277 0.02 DNAJC5
DnaJ (Hsp40) homolog, subfamily C, member 5
9317
0.07
chr9_35605722_35606427 0.02 TESK1
testis-specific kinase 1
707
0.45
chr2_18479767_18479918 0.02 ENSG00000212455
.
257843
0.02
chr12_15881266_15881472 0.02 EPS8
epidermal growth factor receptor pathway substrate 8
170
0.97
chr16_22584462_22584656 0.02 RP11-368J21.3

26274
0.17
chr5_178017459_178017882 0.02 COL23A1
collagen, type XXIII, alpha 1
114
0.97
chr19_10229600_10230538 0.02 EIF3G
eukaryotic translation initiation factor 3, subunit G
471
0.6
chr10_95326560_95326711 0.02 FFAR4
free fatty acid receptor 4
196
0.93
chr1_17616214_17616365 0.02 ENSG00000266634
.
11905
0.15
chr16_89788705_89789477 0.02 ZNF276
zinc finger protein 276
1139
0.28
chr4_55143470_55143900 0.02 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
33943
0.22
chrX_118893537_118893849 0.02 SOWAHD
sosondowah ankyrin repeat domain family member D
1117
0.45
chr18_657791_658473 0.02 C18orf56
chromosome 18 open reading frame 56
137
0.73
chr19_33859506_33859657 0.02 CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
4655
0.22
chr19_708502_708753 0.02 PALM
paralemmin
326
0.8
chr2_43232297_43232448 0.02 ENSG00000207087
.
86260
0.1
chr7_1552899_1553062 0.02 AC102953.6

3917
0.17
chr9_81054275_81054473 0.02 PSAT1
phosphoserine aminotransferase 1
142315
0.05
chr9_29213961_29214112 0.02 ENSG00000215939
.
325083
0.01
chr17_2308923_2309089 0.02 MNT
MAX network transcriptional repressor
4594
0.13
chr20_44639888_44640039 0.02 MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
2416
0.19
chr2_8468645_8468796 0.02 AC011747.7

347176
0.01
chr6_10882168_10882319 0.02 GCM2
glial cells missing homolog 2 (Drosophila)
69
0.72
chr15_66124802_66125877 0.02 ENSG00000252715
.
10483
0.18
chr11_64110647_64110798 0.02 CCDC88B
coiled-coil domain containing 88B
924
0.33
chr8_145734508_145735192 0.02 MFSD3
major facilitator superfamily domain containing 3
393
0.6
chr11_746807_747224 0.02 TALDO1
transaldolase 1
314
0.74
chr1_204380536_204380863 0.01 PPP1R15B
protein phosphatase 1, regulatory subunit 15B
220
0.93
chr8_8820769_8821105 0.01 ENSG00000207244
.
1852
0.35
chr19_17649756_17650554 0.01 FAM129C
family with sequence similarity 129, member C
12042
0.1
chr7_98028694_98029033 0.01 BAIAP2L1
BAI1-associated protein 2-like 1
1517
0.48
chr18_31803030_31803198 0.01 NOL4
nucleolar protein 4
55
0.68
chr21_44013306_44013463 0.01 AP001625.6

31340
0.14
chr2_230195712_230195863 0.01 PID1
phosphotyrosine interaction domain containing 1
59786
0.15
chr17_73872840_73872991 0.01 TRIM47
tripartite motif containing 47
430
0.42
chr9_124988280_124988557 0.01 LHX6
LIM homeobox 6
1447
0.33
chr8_143809061_143809726 0.01 CTD-2292P10.2

285
0.66
chr9_131038025_131038209 0.01 GOLGA2
golgin A2
102
0.73
chr2_75072423_75073024 0.01 HK2
hexokinase 2
10426
0.25
chr7_128337244_128337509 0.01 ENSG00000201041
.
117
0.79
chr19_34973467_34973843 0.01 WTIP
Wilms tumor 1 interacting protein
222
0.92
chr10_47767707_47767858 0.01 ANXA8L2
annexin A8-like 2
20746
0.17
chr20_61846294_61847306 0.01 YTHDF1
YTH domain family, member 1
691
0.57
chr8_43046584_43046788 0.01 HGSNAT
heparan-alpha-glucosaminide N-acetyltransferase
11254
0.22
chr4_113778484_113778635 0.01 RP11-119H12.6

24927
0.19
chr5_179740873_179741196 0.01 GFPT2
glutamine-fructose-6-phosphate transaminase 2
17614
0.17
chr22_37921660_37921818 0.01 CARD10
caspase recruitment domain family, member 10
6190
0.14
chr1_149871196_149871937 0.01 BOLA1
bolA family member 1
387
0.67
chr17_70511481_70511655 0.01 ENSG00000200783
.
148723
0.04
chr7_138720144_138720977 0.01 ZC3HAV1L
zinc finger CCCH-type, antiviral 1-like
215
0.95
chr11_18405572_18406024 0.01 ENSG00000264603
.
3536
0.15
chr6_158423816_158423967 0.01 SYNJ2-IT1
SYNJ2 intronic transcript 1 (non-protein coding)
1752
0.37
chr10_48276074_48276225 0.01 ANXA8
annexin A8
20796
0.13
chr20_35484644_35484795 0.01 SOGA1
suppressor of glucose, autophagy associated 1
3557
0.21
chr1_89536224_89536375 0.01 GBP1
guanylate binding protein 1, interferon-inducible
5256
0.19
chr19_46366604_46366815 0.01 SYMPK
symplekin
161
0.8
chr19_13231168_13231373 0.01 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
2119
0.16
chr5_77840590_77840741 0.01 LHFPL2
lipoma HMGIC fusion partner-like 2
4309
0.35
chr7_5820371_5821002 0.01 RNF216
ring finger protein 216
565
0.76
chr2_129166329_129166512 0.01 ENSG00000238379
.
36352
0.19
chr3_75690482_75691208 0.01 ENSG00000221795
.
10931
0.2
chr3_37670033_37670331 0.01 ENSG00000239105
.
55478
0.15
chr8_82753589_82754405 0.01 SNX16
sorting nexin 16
196
0.96
chr5_115151846_115152134 0.01 CDO1
cysteine dioxygenase type 1
661
0.69
chr11_280225_280457 0.01 NLRP6
NLR family, pyrin domain containing 6
1771
0.15

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0009886 post-embryonic morphogenesis(GO:0009886)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.1 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.0 0.2 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.1 GO:0046087 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0 0.1 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0007616 long-term memory(GO:0007616)
0.0 0.0 GO:0000103 sulfate assimilation(GO:0000103)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.0 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels