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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for RFX3_RFX2

Z-value: 1.68

Motif logo

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Transcription factors associated with RFX3_RFX2

Gene Symbol Gene ID Gene Info
RFX3
ENSG00000080298.11 regulatory factor X3
RFX2
ENSG00000087903.8 regulatory factor X2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_6060606_6060757RFX233870.184856-0.655.9e-02Click!
chr19_6109831_6110198RFX24430.583370-0.627.3e-02Click!
chr19_6060334_6060560RFX231530.191533-0.627.3e-02Click!
chr19_6061582_6061733RFX243630.166615-0.581.0e-01Click!
chr19_6023295_6023446RFX2151330.1304330.571.1e-01Click!
chr9_3241640_3241791RFX3154840.2980430.674.7e-02Click!
chr9_3342385_3342536RFX343040.3559890.501.7e-01Click!
chr9_3525532_3525838RFX32980.9419620.491.8e-01Click!
chr9_3398052_3398553RFX327060.398440-0.452.2e-01Click!
chr9_3507919_3508070RFX3179890.248199-0.422.5e-01Click!

Activity of the RFX3_RFX2 motif across conditions

Conditions sorted by the z-value of the RFX3_RFX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr20_36888706_36889089 0.98 KIAA1755
 KIAA1755
 277
 0.53
chr5_16713576_16713796 0.96 MYO10
 myosin X
 24810
 0.21
chr17_60885608_60885921 0.91 MARCH10
 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
 59
 0.98
chr17_45785766_45785998 0.85 TBKBP1
 TBK1 binding protein 1
 13252
 0.13
chr11_8040357_8041136 0.82 TUB
 tubby bipartite transcription factor
 45
 0.96
chr12_80794329_80794553 0.78 PTPRQ
 protein tyrosine phosphatase, receptor type, Q
 5333
 0.26
chr14_23355781_23356199 0.78 REM2
 RAS (RAD and GEM)-like GTP binding 2
 3559
 0.1
chr7_134468265_134468416 0.72 CALD1
 caldesmon 1
 3911
 0.34
chr19_14048794_14049313 0.71 PODNL1
 podocan-like 1
 144
 0.92
chr10_80008606_80008848 0.67 ENSG00000201393
 .
 118537
 0.06
chr1_44031509_44031896 0.67 PTPRF
 protein tyrosine phosphatase, receptor type, F
 20955
 0.18
chr6_112823116_112823311 0.67 ENSG00000239095
 .
 25285
 0.2
chr16_89990965_89991193 0.65 TUBB3
 Tubulin beta-3 chain
 1305
 0.26
chr5_176873858_176874453 0.59 PRR7
 proline rich 7 (synaptic)
 327
 0.6
chr14_90989296_90989447 0.58 ENSG00000252748
 .
 42114
 0.16
chr14_69052548_69052699 0.58 CTD-2325P2.4
42539
 0.18
chr9_86886547_86886817 0.56 RP11-380F14.2
6452
 0.29
chr6_161664088_161664497 0.55 AGPAT4
 1-acylglycerol-3-phosphate O-acyltransferase 4
 30759
 0.25
chrX_53078377_53078712 0.55 GPR173
 G protein-coupled receptor 173
 79
 0.97
chr17_65524931_65525141 0.54 CTD-2653B5.1
4439
 0.23
chr12_48576703_48577574 0.54 C12orf68
 chromosome 12 open reading frame 68
 228
 0.88
chrX_10584505_10584656 0.53 MID1
 midline 1 (Opitz/BBB syndrome)
 3879
 0.32
chr5_174486834_174487088 0.53 ENSG00000266890
 .
 308224
 0.01
chr20_17816826_17817060 0.52 ENSG00000221220
 .
 6284
 0.24
chr9_94579821_94580301 0.51 ROR2
 receptor tyrosine kinase-like orphan receptor 2
 131101
 0.05
chr2_8818889_8820001 0.50 AC011747.7
259
 0.7
chr4_140823783_140824037 0.50 MAML3
 mastermind-like 3 (Drosophila)
 11789
 0.28
chr7_73448257_73448408 0.48 ELN
 elastin
 5814
 0.21
chr2_5979840_5979991 0.48 DKFZP761K2322
 HCG1990367; Putative uncharacterized protein DKFZp761K2322; Putative uncharacterized protein FLJ30594; Uncharacterized protein; cDNA FLJ30594 fis, clone BRAWH2008903
 131797
 0.05
chr18_21562271_21562511 0.47 TTC39C
 tetratricopeptide repeat domain 39C
 10346
 0.18
chr8_74282720_74282947 0.47 RP11-434I12.2
14137
 0.25
chr2_187713432_187714439 0.46 ZSWIM2
 zinc finger, SWIM-type containing 2
 38
 0.99
chr1_84630171_84630563 0.46 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
 3
 0.99
chr4_140737608_140737759 0.46 ENSG00000252233
 .
 22096
 0.23
chr15_65341843_65342117 0.45 SLC51B
 solute carrier family 51, beta subunit
 4272
 0.15
chr17_64187141_64188685 0.45 CEP112
 centrosomal protein 112kDa
 60
 0.98
chr11_101918104_101918467 0.45 C11orf70
 chromosome 11 open reading frame 70
 96
 0.96
chr22_20143038_20143223 0.45 AC006547.14
 uncharacterized protein LOC388849
 4731
 0.11
chr4_96102666_96102817 0.44 BMPR1B
 bone morphogenetic protein receptor, type IB
 77235
 0.13
chr17_19314379_19314710 0.44 RNF112
 ring finger protein 112
 37
 0.95
chr17_76950200_76950351 0.44 LGALS3BP
 lectin, galactoside-binding, soluble, 3 binding protein
 23130
 0.12
chr1_205283210_205283468 0.43 NUAK2
 NUAK family, SNF1-like kinase, 2
 7544
 0.17
chr5_139418008_139418169 0.43 NRG2
 neuregulin 2
 4566
 0.2
chr3_49055259_49056395 0.43 DALRD3
 DALR anticodon binding domain containing 3
 170
 0.84
chr1_85928394_85928655 0.43 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 1743
 0.41
chr2_175870043_175870550 0.43 CHN1
 chimerin 1
 199
 0.93
chr4_170189368_170189538 0.42 SH3RF1
 SH3 domain containing ring finger 1
 1655
 0.5
chr15_57109701_57109852 0.41 ZNF280D
 zinc finger protein 280D
 83492
 0.1
chr1_111214730_111214881 0.41 KCNA3
 potassium voltage-gated channel, shaker-related subfamily, member 3
 2850
 0.25
chr10_43818085_43818364 0.41 ENSG00000221468
 .
 19010
 0.18
chr10_26829653_26829804 0.40 ENSG00000199733
 .
 31210
 0.22
chr1_54940257_54940662 0.40 ENSG00000265404
 .
 29882
 0.15
chr12_122110363_122110677 0.40 MORN3
 MORN repeat containing 3
 2960
 0.25
chr11_132934198_132934477 0.40 OPCML
 opioid binding protein/cell adhesion molecule-like
 120674
 0.06
chr19_5293472_5293908 0.39 PTPRS
 protein tyrosine phosphatase, receptor type, S
 427
 0.88
chr8_42010434_42011226 0.39 AP3M2
 adaptor-related protein complex 3, mu 2 subunit
 168
 0.83
chr5_61389807_61390019 0.39 ENSG00000251983
 .
 52579
 0.18
chr8_120428169_120429285 0.39 NOV
 nephroblastoma overexpressed
 181
 0.96
chr11_132813791_132813979 0.39 OPCML
 opioid binding protein/cell adhesion molecule-like
 222
 0.96
chr11_45921095_45921634 0.39 MAPK8IP1
 mitogen-activated protein kinase 8 interacting protein 1
 3263
 0.15
chr10_6316976_6317295 0.39 ENSG00000238366
 .
 29341
 0.16
chr7_158766053_158766279 0.38 ENSG00000231419
 .
 34946
 0.21
chrX_47175743_47175914 0.38 ENSG00000266158
 .
 35366
 0.1
chr10_103599730_103600193 0.38 KCNIP2
 Kv channel interacting protein 2
 332
 0.86
chr3_196729783_196730213 0.38 MFI2-AS1
 MFI2 antisense RNA 1
 5
 0.97
chr22_41110494_41110716 0.37 MCHR1
 melanin-concentrating hormone receptor 1
 35328
 0.15
chr9_19493377_19493724 0.37 RP11-363E7.4
40343
 0.16
chr19_10678474_10679697 0.37 CDKN2D
 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
 569
 0.54
chr14_24838154_24838623 0.37 NFATC4
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
 15
 0.95
chr1_155043063_155043480 0.37 EFNA4
 ephrin-A4
 7034
 0.08
chr15_84748384_84748959 0.36 EFTUD1P1
 elongation factor Tu GTP binding domain containing 1 pseudogene 1
 249
 0.94
chr20_291107_291258 0.36 ZCCHC3
 zinc finger, CCHC domain containing 3
 13445
 0.11
chr7_157361164_157361701 0.36 ENSG00000207960
 .
 5682
 0.22
chr1_204034501_204034712 0.35 SOX13
 SRY (sex determining region Y)-box 13
 8126
 0.2
chr19_46919550_46919940 0.35 CCDC8
 coiled-coil domain containing 8
 2904
 0.19
chr1_242097620_242097936 0.34 EXO1
 exonuclease 1
 55436
 0.13
chr16_72965340_72965833 0.34 ENSG00000221799
 .
 53170
 0.13
chr5_111890138_111890295 0.34 EPB41L4A-AS2
 EPB41L4A antisense RNA 2 (head to head)
 134936
 0.05
chr6_132268739_132268890 0.34 RP11-69I8.3
3272
 0.26
chr22_43539145_43539583 0.34 MCAT
 malonyl CoA:ACP acyltransferase (mitochondrial)
 6
 0.97
chr12_56131718_56132374 0.34 GDF11
 growth differentiation factor 11
 5018
 0.09
chr1_203445281_203445432 0.34 PRELP
 proline/arginine-rich end leucine-rich repeat protein
 400
 0.87
chr1_33546320_33546691 0.33 ADC
 arginine decarboxylase
 209
 0.94
chrX_102809591_102809942 0.33 TCEAL4
 transcription elongation factor A (SII)-like 4
 21393
 0.13
chr8_145027093_145027557 0.33 PLEC
 plectin
 763
 0.48
chr5_122181350_122181750 0.33 SNX24
 sorting nexin 24
 229
 0.93
chr1_244175541_244175807 0.33 ZBTB18
 zinc finger and BTB domain containing 18
 38911
 0.17
chr1_179050699_179051584 0.33 TOR3A
 torsin family 3, member A
 64
 0.98
chr10_79006464_79006615 0.32 RP11-328K22.1
67160
 0.12
chr7_1181998_1182149 0.32 C7orf50
 chromosome 7 open reading frame 50
 4177
 0.16
chr4_186853773_186853924 0.31 ENSG00000239034
 .
 13389
 0.21
chr8_102092961_102093560 0.31 ENSG00000202360
 .
 56927
 0.13
chr6_3179788_3179988 0.31 TUBB2A
 tubulin, beta 2A class IIa
 22128
 0.13
chr17_37388032_37388399 0.30 STAC2
 SH3 and cysteine rich domain 2
 6090
 0.15
chr4_186125321_186125752 0.30 SNX25
 sorting nexin 25
 145
 0.75
chr18_43206329_43206480 0.30 SLC14A2
 solute carrier family 14 (urea transporter), member 2
 11638
 0.2
chr2_242606070_242606221 0.30 ATG4B
 autophagy related 4B, cysteine peptidase
 134
 0.93
chr17_46089516_46089790 0.30 RP11-6N17.10
16091
 0.08
chr6_164506356_164506803 0.30 ENSG00000266128
 .
 244986
 0.02
chr12_94580654_94580885 0.30 RP11-74K11.2
949
 0.61
chr3_158288685_158288908 0.30 RP11-538P18.2
59
 0.64
chr1_173638556_173639045 0.30 ANKRD45
 ankyrin repeat domain 45
 201
 0.93
chr1_15573540_15574233 0.30 FHAD1
 forkhead-associated (FHA) phosphopeptide binding domain 1
 110
 0.97
chr18_44526809_44527253 0.30 KATNAL2
 katanin p60 subunit A-like 2
 213
 0.91
chr8_144302159_144302531 0.29 GPIHBP1
 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
 7277
 0.14
chr15_42066837_42067403 0.29 MAPKBP1
 mitogen-activated protein kinase binding protein 1
 220
 0.9
chr4_87280706_87281702 0.29 MAPK10
 mitogen-activated protein kinase 10
 12
 0.98
chr7_136795005_136795156 0.29 hsa-mir-490
 hsa-mir-490
 53937
 0.17
chr12_109548691_109549386 0.29 RP11-968O1.5
15
 0.96
chr15_92237487_92237638 0.29 ENSG00000238981
 .
 141047
 0.05
chr13_24554384_24554726 0.29 SPATA13
 spermatogenesis associated 13
 611
 0.77
chr11_8832007_8832297 0.29 ST5
 suppression of tumorigenicity 5
 44
 0.97
chr21_44061431_44061649 0.29 AP001626.2
9814
 0.18
chr19_38705050_38705201 0.29 DPF1
 D4, zinc and double PHD fingers family 1
 8688
 0.1
chr22_37448126_37448435 0.29 KCTD17
 potassium channel tetramerization domain containing 17
 70
 0.94
chr12_7037386_7038830 0.28 ATN1
 atrophin 1
 632
 0.41
chr9_82278752_82279150 0.28 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 11443
 0.33
chr19_47249862_47250221 0.28 STRN4
 striatin, calmodulin binding protein 4
 97
 0.53
chr6_32119881_32120041 0.28 PRRT1
 proline-rich transmembrane protein 1
 82
 0.9
chr2_220083227_220083846 0.28 ABCB6
 ATP-binding cassette, sub-family B (MDR/TAP), member 6
 136
 0.88
chr19_52193570_52193969 0.27 ENSG00000207550
 .
 2096
 0.15
chr17_39560147_39560298 0.27 AC003958.2
1547
 0.2
chr16_57662077_57662305 0.27 GPR56
 G protein-coupled receptor 56
 21
 0.97
chr6_43612507_43612686 0.27 RSPH9
 radial spoke head 9 homolog (Chlamydomonas)
 187
 0.91
chr1_179783744_179784035 0.27 RP11-12M5.3
2670
 0.26
chrX_70365452_70365975 0.27 NLGN3
 neuroligin 3
 1001
 0.39
chr3_156874639_156874950 0.27 CCNL1
 cyclin L1
 3208
 0.18
chr3_45068445_45068596 0.26 CLEC3B
 C-type lectin domain family 3, member B
 845
 0.58
chr7_50850197_50851001 0.26 GRB10
 growth factor receptor-bound protein 10
 335
 0.93
chr8_22860264_22860415 0.26 PEBP4
 phosphatidylethanolamine-binding protein 4
 2826
 0.17
chr7_129781517_129782004 0.26 RP11-775D22.2
182
 0.94
chr16_2892196_2892619 0.26 ZG16B
 zymogen granule protein 16B
 12038
 0.08
chr8_142141364_142141568 0.25 RP11-809O17.1
1406
 0.4
chr6_28979234_28979409 0.25 ZNF311
 zinc finger protein 311
 6284
 0.13
chr1_148532242_148532716 0.25 NBPF15
 neuroblastoma breakpoint family, member 15
 28364
 0.22
chr1_198650996_198651147 0.25 RP11-553K8.5
14881
 0.25
chr12_48690908_48691108 0.25 H1FNT
 H1 histone family, member N, testis-specific
 31755
 0.12
chr3_38080498_38081224 0.25 DLEC1
 deleted in lung and esophageal cancer 1
 165
 0.94
chr19_48948815_48949184 0.24 GRWD1
 glutamate-rich WD repeat containing 1
 31
 0.95
chr16_67564286_67564635 0.24 FAM65A
 family with sequence similarity 65, member A
 766
 0.44
chr19_47353649_47354096 0.24 AP2S1
 adaptor-related protein complex 2, sigma 1 subunit
 151
 0.95
chr1_15852991_15853242 0.24 DNAJC16
 DnaJ (Hsp40) homolog, subfamily C, member 16
 192
 0.89
chr14_75777417_75777662 0.24 FOS
 FBJ murine osteosarcoma viral oncogene homolog
 30643
 0.14
chr17_70338672_70338823 0.24 SOX9
 SRY (sex determining region Y)-box 9
 221586
 0.02
chr2_174855935_174856086 0.24 SP3
 Sp3 transcription factor
 25580
 0.26
chr5_140893341_140893614 0.24 DIAPH1
 diaphanous-related formin 1
 12237
 0.09
chr12_58146355_58146506 0.24 CDK4
 cyclin-dependent kinase 4
 126
 0.88
chr17_41176429_41177125 0.23 VAT1
 vesicle amine transport 1
 362
 0.51
chr15_40762663_40763059 0.23 CHST14
 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
 299
 0.8
chr16_4049606_4049757 0.23 ADCY9
 adenylate cyclase 9
 10680
 0.18
chr19_19729670_19729882 0.23 PBX4
 pre-B-cell leukemia homeobox 4
 51
 0.96
chr12_2921492_2921671 0.23 RP4-816N1.6
34
 0.71
chr8_6407769_6407977 0.23 ANGPT2
 angiopoietin 2
 12692
 0.26
chr3_57529834_57530279 0.22 DNAH12
 dynein, axonemal, heavy chain 12
 12
 0.96
chr3_125321989_125322196 0.22 OSBPL11
 oxysterol binding protein-like 11
 8158
 0.22
chr22_25506820_25506976 0.22 CTA-221G9.11
1761
 0.41
chr1_144573049_144573284 0.22 ENSG00000201699
 .
 39128
 0.14
chr16_30568785_30569715 0.22 ZNF764
 zinc finger protein 764
 334
 0.43
chr6_35181325_35181573 0.22 SCUBE3
 signal peptide, CUB domain, EGF-like 3
 741
 0.69
chr2_132285357_132286129 0.22 CCDC74A
 coiled-coil domain containing 74A
 290
 0.91
chr10_120101830_120102206 0.22 FAM204A
 family with sequence similarity 204, member A
 186
 0.97
chr7_48075055_48075727 0.22 C7orf57
 chromosome 7 open reading frame 57
 274
 0.91
chr5_61708037_61708393 0.22 IPO11
 importin 11
 273
 0.91
chr8_22462053_22462924 0.22 CCAR2
 cell cycle and apoptosis regulator 2
 63
 0.94
chr1_201600215_201600366 0.22 NAV1
 neuron navigator 1
 7689
 0.16
chr17_7117806_7118379 0.22 DLG4
 discs, large homolog 4 (Drosophila)
 861
 0.31
chr9_34620609_34620827 0.21 DCTN3
 dynactin 3 (p22)
 203
 0.86
chr14_57046308_57046738 0.21 TMEM260
 transmembrane protein 260
 12
 0.99
chr14_59628263_59628414 0.21 DAAM1
 dishevelled associated activator of morphogenesis 1
 27060
 0.26
chr7_5184079_5184242 0.21 ZNF890P
 zinc finger protein 890, pseudogene
 16734
 0.17
chr18_380848_380999 0.21 RP11-720L2.2
43493
 0.16
chr21_39286916_39287067 0.21 KCNJ6
 potassium inwardly-rectifying channel, subfamily J, member 6
 1434
 0.51
chr17_60947671_60947822 0.21 MARCH10
 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
 62041
 0.12
chr2_130901985_130902795 0.21 CCDC74B
 coiled-coil domain containing 74B
 177
 0.9
chr2_3200081_3200232 0.20 TSSC1-IT1
 TSSC1 intronic transcript 1 (non-protein coding)
 105080
 0.07
chr21_33952233_33952384 0.20 TCP10L
 t-complex 10-like
 5535
 0.15
chr12_51818248_51818602 0.20 RP11-607P23.1
30
 0.62
chr8_145024226_145024570 0.20 PLEC
 plectin
 646
 0.55
chr17_76320400_76320721 0.20 SOCS3
 suppressor of cytokine signaling 3
 35595
 0.11
chr1_183440636_183441395 0.20 SMG7
 SMG7 nonsense mediated mRNA decay factor
 491
 0.83
chrX_71351813_71352291 0.20 RGAG4
 retrotransposon gag domain containing 4
 294
 0.84
chr7_1576476_1576960 0.20 MAFK
 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
 1626
 0.3
chr5_148521385_148522083 0.20 ABLIM3
 actin binding LIM protein family, member 3
 124
 0.96
chr1_172352648_172352805 0.20 DNM3
 dynamin 3
 4568
 0.19
chr2_178482857_178483675 0.20 TTC30A
 tetratricopeptide repeat domain 30A
 428
 0.84
chr11_47600251_47600536 0.20 KBTBD4
 kelch repeat and BTB (POZ) domain containing 4
 52
 0.64
chr3_138047908_138048749 0.19 NME9
 NME/NM23 family member 9
 123
 0.97
chr12_106736611_106736853 0.19 POLR3B
 polymerase (RNA) III (DNA directed) polypeptide B
 14704
 0.19
chr14_59931736_59932162 0.19 GPR135
 G protein-coupled receptor 135
 111
 0.97
chr9_35828652_35829114 0.19 FAM221B
 family with sequence similarity 221, member B
 154
 0.7
chr8_22084641_22084931 0.19 PHYHIP
 phytanoyl-CoA 2-hydroxylase interacting protein
 420
 0.76
chr10_31891715_31891977 0.19 ENSG00000222412
 .
 153218
 0.04
chr19_56826038_56826226 0.18 ZSCAN5A
 zinc finger and SCAN domain containing 5A
 25
 0.51
chr9_140024279_140024727 0.18 ENSG00000238824
 .
 6443
 0.06
chr6_139644906_139645379 0.18 TXLNB
 taxilin beta
 31866
 0.17
chr6_30640170_30640817 0.18 DHX16
 DEAH (Asp-Glu-Ala-His) box polypeptide 16
 272
 0.78
chr19_37803327_37803721 0.18 HKR1
 HKR1, GLI-Kruppel zinc finger family member
 215
 0.93
chr21_44061692_44061930 0.18 AP001626.2
9543
 0.18
chr2_3286362_3286843 0.18 TSSC1-IT1
 TSSC1 intronic transcript 1 (non-protein coding)
 18634
 0.24
chr18_47833726_47834243 0.18 ENSG00000251997
 .
 11388
 0.15

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 0.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.2 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.1 0.3 GO:0006591 ornithine metabolic process(GO:0006591)
0.1 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.3 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.4 GO:0032717 negative regulation of interleukin-8 production(GO:0032717)
0.1 0.5 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:2000188 regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.8 GO:0050766 positive regulation of phagocytosis(GO:0050766)
0.0 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.2 GO:0050655 dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.0 0.3 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.2 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.5 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477)
0.0 0.2 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.0 0.1 GO:0048548 regulation of pinocytosis(GO:0048548)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:1901538 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.2 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.4 GO:0008038 neuron recognition(GO:0008038)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.3 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.1 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.1 GO:0051299 centrosome separation(GO:0051299)
0.0 0.0 GO:0019322 pentose biosynthetic process(GO:0019322)
0.0 0.0 GO:0060632 regulation of microtubule-based movement(GO:0060632)
0.0 0.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.0 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.4 GO:0000080 mitotic G1 phase(GO:0000080)
0.0 0.0 GO:0060058 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.0 GO:0071503 response to heparin(GO:0071503)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:2000178 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.0 GO:0021932 hindbrain radial glia guided cell migration(GO:0021932)
0.0 0.1 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.0 0.0 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.1 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.0 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.0 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:0016236 macroautophagy(GO:0016236)
0.0 0.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.0 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.0 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0015871 choline transport(GO:0015871)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.3 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.2 GO:0001741 XY body(GO:0001741)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.0 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.0 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.3 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.1 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.4 GO:0004985 opioid receptor activity(GO:0004985)
0.1 0.4 GO:0051636 obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.1 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.2 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0097493 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.2 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.3 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.4 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.0 GO:0032142 single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0 0.4 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.1 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.1 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.1 GO:0046978 TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0 0.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.0 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.0 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.7 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.3 PID IGF1 PATHWAY IGF1 pathway
0.0 0.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 ST GA12 PATHWAY G alpha 12 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.1 REACTOME GABA RECEPTOR ACTIVATION Genes involved in GABA receptor activation