Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RFX3_RFX2

Z-value: 1.68

Motif logo

Transcription factors associated with RFX3_RFX2

Gene Symbol	Gene ID	Gene Info
RFX3 Ensembl NCBI GeneCards UniProt	ENSG00000080298.11	RFX3
RFX2 Ensembl NCBI GeneCards UniProt	ENSG00000087903.8	RFX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
RFX2	chr19_6060606_6060757	3387	0.184856	-0.65	5.9e-02	Click!
RFX2	chr19_6109831_6110198	443	0.583370	-0.62	7.3e-02	Click!
RFX2	chr19_6060334_6060560	3153	0.191533	-0.62	7.3e-02	Click!
RFX2	chr19_6061582_6061733	4363	0.166615	-0.58	1.0e-01	Click!
RFX2	chr19_6023295_6023446	15133	0.130433	0.57	1.1e-01	Click!
RFX3	chr9_3241640_3241791	15484	0.298043	0.67	4.7e-02	Click!
RFX3	chr9_3342385_3342536	4304	0.355989	0.50	1.7e-01	Click!
RFX3	chr9_3525532_3525838	298	0.941962	0.49	1.8e-01	Click!
RFX3	chr9_3398052_3398553	2706	0.398440	-0.45	2.2e-01	Click!
RFX3	chr9_3507919_3508070	17989	0.248199	-0.42	2.5e-01	Click!

Activity of the RFX3_RFX2 motif across conditions

Conditions sorted by the z-value of the RFX3_RFX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr20_36888706_36889089	0.98	KIAA1755	KIAA1755	277	0.53
chr5_16713576_16713796	0.96	MYO10	myosin X	24810	0.21
chr17_60885608_60885921	0.91	MARCH10	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	59	0.98
chr17_45785766_45785998	0.85	TBKBP1	TBK1 binding protein 1	13252	0.13
chr11_8040357_8041136	0.82	TUB	tubby bipartite transcription factor	45	0.96
chr12_80794329_80794553	0.78	PTPRQ	protein tyrosine phosphatase, receptor type, Q	5333	0.26
chr14_23355781_23356199	0.78	REM2	RAS (RAD and GEM)-like GTP binding 2	3559	0.1
chr7_134468265_134468416	0.72	CALD1	caldesmon 1	3911	0.34
chr19_14048794_14049313	0.71	PODNL1	podocan-like 1	144	0.92
chr10_80008606_80008848	0.67	ENSG00000201393	.	118537	0.06
chr1_44031509_44031896	0.67	PTPRF	protein tyrosine phosphatase, receptor type, F	20955	0.18
chr6_112823116_112823311	0.67	ENSG00000239095	.	25285	0.2
chr16_89990965_89991193	0.65	TUBB3	Tubulin beta-3 chain	1305	0.26
chr5_176873858_176874453	0.59	PRR7	proline rich 7 (synaptic)	327	0.6
chr14_90989296_90989447	0.58	ENSG00000252748	.	42114	0.16
chr14_69052548_69052699	0.58	CTD-2325P2.4		42539	0.18
chr9_86886547_86886817	0.56	RP11-380F14.2		6452	0.29
chr6_161664088_161664497	0.55	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4	30759	0.25
chrX_53078377_53078712	0.55	GPR173	G protein-coupled receptor 173	79	0.97
chr17_65524931_65525141	0.54	CTD-2653B5.1		4439	0.23
chr12_48576703_48577574	0.54	C12orf68	chromosome 12 open reading frame 68	228	0.88
chrX_10584505_10584656	0.53	MID1	midline 1 (Opitz/BBB syndrome)	3879	0.32
chr5_174486834_174487088	0.53	ENSG00000266890	.	308224	0.01
chr20_17816826_17817060	0.52	ENSG00000221220	.	6284	0.24
chr9_94579821_94580301	0.51	ROR2	receptor tyrosine kinase-like orphan receptor 2	131101	0.05
chr2_8818889_8820001	0.50	AC011747.7		259	0.7
chr4_140823783_140824037	0.50	MAML3	mastermind-like 3 (Drosophila)	11789	0.28
chr7_73448257_73448408	0.48	ELN	elastin	5814	0.21
chr2_5979840_5979991	0.48	DKFZP761K2322	HCG1990367; Putative uncharacterized protein DKFZp761K2322; Putative uncharacterized protein FLJ30594; Uncharacterized protein; cDNA FLJ30594 fis, clone BRAWH2008903	131797	0.05
chr18_21562271_21562511	0.47	TTC39C	tetratricopeptide repeat domain 39C	10346	0.18
chr8_74282720_74282947	0.47	RP11-434I12.2		14137	0.25
chr2_187713432_187714439	0.46	ZSWIM2	zinc finger, SWIM-type containing 2	38	0.99
chr1_84630171_84630563	0.46	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	3	0.99
chr4_140737608_140737759	0.46	ENSG00000252233	.	22096	0.23
chr15_65341843_65342117	0.45	SLC51B	solute carrier family 51, beta subunit	4272	0.15
chr17_64187141_64188685	0.45	CEP112	centrosomal protein 112kDa	60	0.98
chr11_101918104_101918467	0.45	C11orf70	chromosome 11 open reading frame 70	96	0.96
chr22_20143038_20143223	0.45	AC006547.14	uncharacterized protein LOC388849	4731	0.11
chr4_96102666_96102817	0.44	BMPR1B	bone morphogenetic protein receptor, type IB	77235	0.13
chr17_19314379_19314710	0.44	RNF112	ring finger protein 112	37	0.95
chr17_76950200_76950351	0.44	LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	23130	0.12
chr1_205283210_205283468	0.43	NUAK2	NUAK family, SNF1-like kinase, 2	7544	0.17
chr5_139418008_139418169	0.43	NRG2	neuregulin 2	4566	0.2
chr3_49055259_49056395	0.43	DALRD3	DALR anticodon binding domain containing 3	170	0.84
chr1_85928394_85928655	0.43	DDAH1	dimethylarginine dimethylaminohydrolase 1	1743	0.41
chr2_175870043_175870550	0.43	CHN1	chimerin 1	199	0.93
chr4_170189368_170189538	0.42	SH3RF1	SH3 domain containing ring finger 1	1655	0.5
chr15_57109701_57109852	0.41	ZNF280D	zinc finger protein 280D	83492	0.1
chr1_111214730_111214881	0.41	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	2850	0.25
chr10_43818085_43818364	0.41	ENSG00000221468	.	19010	0.18
chr10_26829653_26829804	0.40	ENSG00000199733	.	31210	0.22
chr1_54940257_54940662	0.40	ENSG00000265404	.	29882	0.15
chr12_122110363_122110677	0.40	MORN3	MORN repeat containing 3	2960	0.25
chr11_132934198_132934477	0.40	OPCML	opioid binding protein/cell adhesion molecule-like	120674	0.06
chr19_5293472_5293908	0.39	PTPRS	protein tyrosine phosphatase, receptor type, S	427	0.88
chr8_42010434_42011226	0.39	AP3M2	adaptor-related protein complex 3, mu 2 subunit	168	0.83
chr5_61389807_61390019	0.39	ENSG00000251983	.	52579	0.18
chr8_120428169_120429285	0.39	NOV	nephroblastoma overexpressed	181	0.96
chr11_132813791_132813979	0.39	OPCML	opioid binding protein/cell adhesion molecule-like	222	0.96
chr11_45921095_45921634	0.39	MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	3263	0.15
chr10_6316976_6317295	0.39	ENSG00000238366	.	29341	0.16
chr7_158766053_158766279	0.38	ENSG00000231419	.	34946	0.21
chrX_47175743_47175914	0.38	ENSG00000266158	.	35366	0.1
chr10_103599730_103600193	0.38	KCNIP2	Kv channel interacting protein 2	332	0.86
chr3_196729783_196730213	0.38	MFI2-AS1	MFI2 antisense RNA 1	5	0.97
chr22_41110494_41110716	0.37	MCHR1	melanin-concentrating hormone receptor 1	35328	0.15
chr9_19493377_19493724	0.37	RP11-363E7.4		40343	0.16
chr19_10678474_10679697	0.37	CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	569	0.54
chr14_24838154_24838623	0.37	NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	15	0.95
chr1_155043063_155043480	0.37	EFNA4	ephrin-A4	7034	0.08
chr15_84748384_84748959	0.36	EFTUD1P1	elongation factor Tu GTP binding domain containing 1 pseudogene 1	249	0.94
chr20_291107_291258	0.36	ZCCHC3	zinc finger, CCHC domain containing 3	13445	0.11
chr7_157361164_157361701	0.36	ENSG00000207960	.	5682	0.22
chr1_204034501_204034712	0.35	SOX13	SRY (sex determining region Y)-box 13	8126	0.2
chr19_46919550_46919940	0.35	CCDC8	coiled-coil domain containing 8	2904	0.19
chr1_242097620_242097936	0.34	EXO1	exonuclease 1	55436	0.13
chr16_72965340_72965833	0.34	ENSG00000221799	.	53170	0.13
chr5_111890138_111890295	0.34	EPB41L4A-AS2	EPB41L4A antisense RNA 2 (head to head)	134936	0.05
chr6_132268739_132268890	0.34	RP11-69I8.3		3272	0.26
chr22_43539145_43539583	0.34	MCAT	malonyl CoA:ACP acyltransferase (mitochondrial)	6	0.97
chr12_56131718_56132374	0.34	GDF11	growth differentiation factor 11	5018	0.09
chr1_203445281_203445432	0.34	PRELP	proline/arginine-rich end leucine-rich repeat protein	400	0.87
chr1_33546320_33546691	0.33	ADC	arginine decarboxylase	209	0.94
chrX_102809591_102809942	0.33	TCEAL4	transcription elongation factor A (SII)-like 4	21393	0.13
chr8_145027093_145027557	0.33	PLEC	plectin	763	0.48
chr5_122181350_122181750	0.33	SNX24	sorting nexin 24	229	0.93
chr1_244175541_244175807	0.33	ZBTB18	zinc finger and BTB domain containing 18	38911	0.17
chr1_179050699_179051584	0.33	TOR3A	torsin family 3, member A	64	0.98
chr10_79006464_79006615	0.32	RP11-328K22.1		67160	0.12
chr7_1181998_1182149	0.32	C7orf50	chromosome 7 open reading frame 50	4177	0.16
chr4_186853773_186853924	0.31	ENSG00000239034	.	13389	0.21
chr8_102092961_102093560	0.31	ENSG00000202360	.	56927	0.13
chr6_3179788_3179988	0.31	TUBB2A	tubulin, beta 2A class IIa	22128	0.13
chr17_37388032_37388399	0.30	STAC2	SH3 and cysteine rich domain 2	6090	0.15
chr4_186125321_186125752	0.30	SNX25	sorting nexin 25	145	0.75
chr18_43206329_43206480	0.30	SLC14A2	solute carrier family 14 (urea transporter), member 2	11638	0.2
chr2_242606070_242606221	0.30	ATG4B	autophagy related 4B, cysteine peptidase	134	0.93
chr17_46089516_46089790	0.30	RP11-6N17.10		16091	0.08
chr6_164506356_164506803	0.30	ENSG00000266128	.	244986	0.02
chr12_94580654_94580885	0.30	RP11-74K11.2		949	0.61
chr3_158288685_158288908	0.30	RP11-538P18.2		59	0.64
chr1_173638556_173639045	0.30	ANKRD45	ankyrin repeat domain 45	201	0.93
chr1_15573540_15574233	0.30	FHAD1	forkhead-associated (FHA) phosphopeptide binding domain 1	110	0.97
chr18_44526809_44527253	0.30	KATNAL2	katanin p60 subunit A-like 2	213	0.91
chr8_144302159_144302531	0.29	GPIHBP1	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	7277	0.14
chr15_42066837_42067403	0.29	MAPKBP1	mitogen-activated protein kinase binding protein 1	220	0.9
chr4_87280706_87281702	0.29	MAPK10	mitogen-activated protein kinase 10	12	0.98
chr7_136795005_136795156	0.29	hsa-mir-490	hsa-mir-490	53937	0.17
chr12_109548691_109549386	0.29	RP11-968O1.5		15	0.96
chr15_92237487_92237638	0.29	ENSG00000238981	.	141047	0.05
chr13_24554384_24554726	0.29	SPATA13	spermatogenesis associated 13	611	0.77
chr11_8832007_8832297	0.29	ST5	suppression of tumorigenicity 5	44	0.97
chr21_44061431_44061649	0.29	AP001626.2		9814	0.18
chr19_38705050_38705201	0.29	DPF1	D4, zinc and double PHD fingers family 1	8688	0.1
chr22_37448126_37448435	0.29	KCTD17	potassium channel tetramerization domain containing 17	70	0.94
chr12_7037386_7038830	0.28	ATN1	atrophin 1	632	0.41
chr9_82278752_82279150	0.28	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	11443	0.33
chr19_47249862_47250221	0.28	STRN4	striatin, calmodulin binding protein 4	97	0.53
chr6_32119881_32120041	0.28	PRRT1	proline-rich transmembrane protein 1	82	0.9
chr2_220083227_220083846	0.28	ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6	136	0.88
chr19_52193570_52193969	0.27	ENSG00000207550	.	2096	0.15
chr17_39560147_39560298	0.27	AC003958.2		1547	0.2
chr16_57662077_57662305	0.27	GPR56	G protein-coupled receptor 56	21	0.97
chr6_43612507_43612686	0.27	RSPH9	radial spoke head 9 homolog (Chlamydomonas)	187	0.91
chr1_179783744_179784035	0.27	RP11-12M5.3		2670	0.26
chrX_70365452_70365975	0.27	NLGN3	neuroligin 3	1001	0.39
chr3_156874639_156874950	0.27	CCNL1	cyclin L1	3208	0.18
chr3_45068445_45068596	0.26	CLEC3B	C-type lectin domain family 3, member B	845	0.58
chr7_50850197_50851001	0.26	GRB10	growth factor receptor-bound protein 10	335	0.93
chr8_22860264_22860415	0.26	PEBP4	phosphatidylethanolamine-binding protein 4	2826	0.17
chr7_129781517_129782004	0.26	RP11-775D22.2		182	0.94
chr16_2892196_2892619	0.26	ZG16B	zymogen granule protein 16B	12038	0.08
chr8_142141364_142141568	0.25	RP11-809O17.1		1406	0.4
chr6_28979234_28979409	0.25	ZNF311	zinc finger protein 311	6284	0.13
chr1_148532242_148532716	0.25	NBPF15	neuroblastoma breakpoint family, member 15	28364	0.22
chr1_198650996_198651147	0.25	RP11-553K8.5		14881	0.25
chr12_48690908_48691108	0.25	H1FNT	H1 histone family, member N, testis-specific	31755	0.12
chr3_38080498_38081224	0.25	DLEC1	deleted in lung and esophageal cancer 1	165	0.94
chr19_48948815_48949184	0.24	GRWD1	glutamate-rich WD repeat containing 1	31	0.95
chr16_67564286_67564635	0.24	FAM65A	family with sequence similarity 65, member A	766	0.44
chr19_47353649_47354096	0.24	AP2S1	adaptor-related protein complex 2, sigma 1 subunit	151	0.95
chr1_15852991_15853242	0.24	DNAJC16	DnaJ (Hsp40) homolog, subfamily C, member 16	192	0.89
chr14_75777417_75777662	0.24	FOS	FBJ murine osteosarcoma viral oncogene homolog	30643	0.14
chr17_70338672_70338823	0.24	SOX9	SRY (sex determining region Y)-box 9	221586	0.02
chr2_174855935_174856086	0.24	SP3	Sp3 transcription factor	25580	0.26
chr5_140893341_140893614	0.24	DIAPH1	diaphanous-related formin 1	12237	0.09
chr12_58146355_58146506	0.24	CDK4	cyclin-dependent kinase 4	126	0.88
chr17_41176429_41177125	0.23	VAT1	vesicle amine transport 1	362	0.51
chr15_40762663_40763059	0.23	CHST14	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	299	0.8
chr16_4049606_4049757	0.23	ADCY9	adenylate cyclase 9	10680	0.18
chr19_19729670_19729882	0.23	PBX4	pre-B-cell leukemia homeobox 4	51	0.96
chr12_2921492_2921671	0.23	RP4-816N1.6		34	0.71
chr8_6407769_6407977	0.23	ANGPT2	angiopoietin 2	12692	0.26
chr3_57529834_57530279	0.22	DNAH12	dynein, axonemal, heavy chain 12	12	0.96
chr3_125321989_125322196	0.22	OSBPL11	oxysterol binding protein-like 11	8158	0.22
chr22_25506820_25506976	0.22	CTA-221G9.11		1761	0.41
chr1_144573049_144573284	0.22	ENSG00000201699	.	39128	0.14
chr16_30568785_30569715	0.22	ZNF764	zinc finger protein 764	334	0.43
chr6_35181325_35181573	0.22	SCUBE3	signal peptide, CUB domain, EGF-like 3	741	0.69
chr2_132285357_132286129	0.22	CCDC74A	coiled-coil domain containing 74A	290	0.91
chr10_120101830_120102206	0.22	FAM204A	family with sequence similarity 204, member A	186	0.97
chr7_48075055_48075727	0.22	C7orf57	chromosome 7 open reading frame 57	274	0.91
chr5_61708037_61708393	0.22	IPO11	importin 11	273	0.91
chr8_22462053_22462924	0.22	CCAR2	cell cycle and apoptosis regulator 2	63	0.94
chr1_201600215_201600366	0.22	NAV1	neuron navigator 1	7689	0.16
chr17_7117806_7118379	0.22	DLG4	discs, large homolog 4 (Drosophila)	861	0.31
chr9_34620609_34620827	0.21	DCTN3	dynactin 3 (p22)	203	0.86
chr14_57046308_57046738	0.21	TMEM260	transmembrane protein 260	12	0.99
chr14_59628263_59628414	0.21	DAAM1	dishevelled associated activator of morphogenesis 1	27060	0.26
chr7_5184079_5184242	0.21	ZNF890P	zinc finger protein 890, pseudogene	16734	0.17
chr18_380848_380999	0.21	RP11-720L2.2		43493	0.16
chr21_39286916_39287067	0.21	KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	1434	0.51
chr17_60947671_60947822	0.21	MARCH10	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	62041	0.12
chr2_130901985_130902795	0.21	CCDC74B	coiled-coil domain containing 74B	177	0.9
chr2_3200081_3200232	0.20	TSSC1-IT1	TSSC1 intronic transcript 1 (non-protein coding)	105080	0.07
chr21_33952233_33952384	0.20	TCP10L	t-complex 10-like	5535	0.15
chr12_51818248_51818602	0.20	RP11-607P23.1		30	0.62
chr8_145024226_145024570	0.20	PLEC	plectin	646	0.55
chr17_76320400_76320721	0.20	SOCS3	suppressor of cytokine signaling 3	35595	0.11
chr1_183440636_183441395	0.20	SMG7	SMG7 nonsense mediated mRNA decay factor	491	0.83
chrX_71351813_71352291	0.20	RGAG4	retrotransposon gag domain containing 4	294	0.84
chr7_1576476_1576960	0.20	MAFK	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K	1626	0.3
chr5_148521385_148522083	0.20	ABLIM3	actin binding LIM protein family, member 3	124	0.96
chr1_172352648_172352805	0.20	DNM3	dynamin 3	4568	0.19
chr2_178482857_178483675	0.20	TTC30A	tetratricopeptide repeat domain 30A	428	0.84
chr11_47600251_47600536	0.20	KBTBD4	kelch repeat and BTB (POZ) domain containing 4	52	0.64
chr3_138047908_138048749	0.19	NME9	NME/NM23 family member 9	123	0.97
chr12_106736611_106736853	0.19	POLR3B	polymerase (RNA) III (DNA directed) polypeptide B	14704	0.19
chr14_59931736_59932162	0.19	GPR135	G protein-coupled receptor 135	111	0.97
chr9_35828652_35829114	0.19	FAM221B	family with sequence similarity 221, member B	154	0.7
chr8_22084641_22084931	0.19	PHYHIP	phytanoyl-CoA 2-hydroxylase interacting protein	420	0.76
chr10_31891715_31891977	0.19	ENSG00000222412	.	153218	0.04
chr19_56826038_56826226	0.18	ZSCAN5A	zinc finger and SCAN domain containing 5A	25	0.51
chr9_140024279_140024727	0.18	ENSG00000238824	.	6443	0.06
chr6_139644906_139645379	0.18	TXLNB	taxilin beta	31866	0.17
chr6_30640170_30640817	0.18	DHX16	DEAH (Asp-Glu-Ala-His) box polypeptide 16	272	0.78
chr19_37803327_37803721	0.18	HKR1	HKR1, GLI-Kruppel zinc finger family member	215	0.93
chr21_44061692_44061930	0.18	AP001626.2		9543	0.18
chr2_3286362_3286843	0.18	TSSC1-IT1	TSSC1 intronic transcript 1 (non-protein coding)	18634	0.24
chr18_47833726_47834243	0.18	ENSG00000251997	.	11388	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.1	0.3	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.2	GO:0097501	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.1	0.3	GO:0006591	ornithine metabolic process(GO:0006591)
0.1	0.3	GO:0007258	JUN phosphorylation(GO:0007258)
0.1	0.3	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.1	0.4	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.1	0.5	GO:0035082	axoneme assembly(GO:0035082)
0.1	0.3	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:2000188	regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.8	GO:0050766	positive regulation of phagocytosis(GO:0050766)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.2	GO:0050655	dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.0	0.3	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.2	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.2	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.5	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.2	GO:0006477	protein sulfation(GO:0006477)
0.0	0.2	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.3	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002)
0.0	0.1	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:1901538	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.2	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.4	GO:0008038	neuron recognition(GO:0008038)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.3	GO:1905037	autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0051299	centrosome separation(GO:0051299)
0.0	0.0	GO:0019322	pentose biosynthetic process(GO:0019322)
0.0	0.0	GO:0060632	regulation of microtubule-based movement(GO:0060632)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.0	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.4	GO:0000080	mitotic G1 phase(GO:0000080)
0.0	0.0	GO:0060058	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.0	GO:0071503	response to heparin(GO:0071503)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.0	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.0	0.1	GO:0043570	maintenance of DNA repeat elements(GO:0043570)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.1	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0	0.2	GO:0030032	lamellipodium assembly(GO:0030032)
0.0	0.0	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.0	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.2	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.1	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.1	GO:0016236	macroautophagy(GO:0016236)
0.0	0.1	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.0	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0015871	choline transport(GO:0015871)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.3	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.2	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.5	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.0	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.0	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.2	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.1	0.3	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.1	0.3	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.1	0.2	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.1	0.2	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.4	GO:0004985	opioid receptor activity(GO:0004985)
0.1	0.4	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.1	0.5	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.3	GO:0016417	S-acyltransferase activity(GO:0016417)
0.1	0.3	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.2	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.2	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0	0.1	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.2	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.5	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.3	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.4	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.2	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.2	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.0	GO:0032142	single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0	0.4	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.4	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.1	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.1	GO:0046978	TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.0	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.0	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.0	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.5	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.7	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.3	PID IGF1 PATHWAY	IGF1 pathway
0.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	ST GA12 PATHWAY	G alpha 12 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.3	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.3	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.3	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	REACTOME GABA RECEPTOR ACTIVATION	Genes involved in GABA receptor activation