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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RUNX3_BCL11A

Z-value: 1.28

Motif logo

Transcription factors associated with RUNX3_BCL11A

Gene Symbol	Gene ID	Gene Info
RUNX3 Ensembl NCBI GeneCards UniProt	ENSG00000020633.14	RUNX3
BCL11A Ensembl NCBI GeneCards UniProt	ENSG00000119866.16	BCL11A

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
BCL11A	chr2_60784499_60784860	3977	0.289631	0.87	2.1e-03	Click!
BCL11A	chr2_60756957_60757205	23459	0.199334	0.82	7.0e-03	Click!
BCL11A	chr2_60783649_60784435	3340	0.308308	0.61	7.8e-02	Click!
BCL11A	chr2_60757710_60758018	22676	0.201763	0.55	1.3e-01	Click!
BCL11A	chr2_60774340_60774491	6125	0.258308	0.49	1.8e-01	Click!
RUNX3	chr1_25247095_25247246	8442	0.232048	-0.61	7.9e-02	Click!
RUNX3	chr1_25253994_25254145	1543	0.448490	0.60	8.8e-02	Click!
RUNX3	chr1_25252382_25252533	3155	0.292404	0.60	9.1e-02	Click!
RUNX3	chr1_25255138_25255978	54	0.980403	0.58	1.0e-01	Click!
RUNX3	chr1_25252115_25252332	3389	0.283851	0.57	1.1e-01	Click!

Activity of the RUNX3_BCL11A motif across conditions

Conditions sorted by the z-value of the RUNX3_BCL11A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_116285976_116286984	0.64	ABLIM1	actin binding LIM protein 1	114	0.98
chr14_91882732_91883366	0.50	CCDC88C	coiled-coil domain containing 88C	641	0.78
chr12_2800154_2801438	0.48	CACNA1C-AS1	CACNA1C antisense RNA 1	430	0.83
chrX_12974492_12974668	0.44	TMSB4X	thymosin beta 4, X-linked	18647	0.19
chr1_1148809_1149188	0.43	TNFRSF4	tumor necrosis factor receptor superfamily, member 4	514	0.56
chr21_40139305_40139870	0.42	ETS2	v-ets avian erythroblastosis virus E26 oncogene homolog 2	37644	0.21
chr19_39029395_39029671	0.42	AC067969.2		1765	0.24
chr2_173327465_173327877	0.41	AC078883.3		3069	0.24
chr9_116635130_116635281	0.39	ZNF618	zinc finger protein 618	3357	0.34
chr16_85649875_85650315	0.39	GSE1	Gse1 coiled-coil protein	3137	0.26
chr2_191929470_191929872	0.38	ENSG00000231858	.	43419	0.12
chr4_84034184_84034613	0.36	PLAC8	placenta-specific 8	1470	0.48
chr19_13215586_13215874	0.35	LYL1	lymphoblastic leukemia derived sequence 1	1755	0.21
chr14_92301921_92302175	0.34	TC2N	tandem C2 domains, nuclear	736	0.7
chr12_47609308_47609580	0.34	PCED1B	PC-esterase domain containing 1B	608	0.77
chr19_16477276_16478284	0.34	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	5016	0.17
chr3_39402780_39403041	0.34	SLC25A38	solute carrier family 25, member 38	21929	0.13
chr5_39203555_39203988	0.32	FYB	FYN binding protein	642	0.81
chr13_41707065_41707565	0.32	KBTBD6	kelch repeat and BTB (POZ) domain containing 6	433	0.79
chr9_92092302_92093120	0.32	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	2094	0.37
chr20_8194475_8194883	0.31	PLCB1-IT1	PLCB1 intronic transcript 1 (non-protein coding)	34672	0.21
chr19_42703347_42703984	0.31	ENSG00000265122	.	6435	0.1
chr17_29640754_29641122	0.31	EVI2B	ecotropic viral integration site 2B	164	0.93
chrX_57313067_57313960	0.31	FAAH2	fatty acid amide hydrolase 2	374	0.92
chr1_117301083_117301385	0.30	CD2	CD2 molecule	4145	0.26
chrX_118815979_118816490	0.30	SEPT6	septin 6	10558	0.17
chr16_29674660_29674967	0.30	QPRT	quinolinate phosphoribosyltransferase	213	0.51
chr12_109027255_109027564	0.30	SELPLG	selectin P ligand	261	0.87
chrX_70842641_70842792	0.30	ENSG00000264855	.	2989	0.24
chr1_232054576_232054868	0.29	DISC1-IT1	DISC1 intronic transcript 1 (non-protein coding)	6858	0.32
chr16_88844628_88844779	0.29	PIEZO1	piezo-type mechanosensitive ion channel component 1	6916	0.09
chr1_85328555_85328706	0.29	LPAR3	lysophosphatidic acid receptor 3	3212	0.32
chr1_117298667_117299007	0.28	CD2	CD2 molecule	1748	0.4
chr2_202097823_202098101	0.28	CASP8	caspase 8, apoptosis-related cysteine peptidase	204	0.94
chr5_75700712_75700863	0.28	IQGAP2	IQ motif containing GTPase activating protein 2	538	0.86
chrX_129225814_129226276	0.28	ELF4	E74-like factor 4 (ets domain transcription factor)	18291	0.19
chr12_10021470_10021931	0.28	CLEC2B	C-type lectin domain family 2, member B	1035	0.4
chr2_54809030_54809206	0.27	SPTBN1	spectrin, beta, non-erythrocytic 1	23587	0.17
chr1_209941174_209941325	0.27	TRAF3IP3	TRAF3 interacting protein 3	584	0.67
chr13_114549320_114549471	0.27	GAS6	growth arrest-specific 6	661	0.76
chr14_71465889_71466177	0.26	PCNX	pecanex homolog (Drosophila)	13715	0.29
chr2_158295494_158296053	0.26	CYTIP	cytohesin 1 interacting protein	153	0.96
chr7_26333293_26333815	0.26	SNX10	sorting nexin 10	880	0.67
chr20_47439188_47439680	0.26	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	4986	0.3
chr9_131831774_131831925	0.26	DOLPP1	dolichyldiphosphatase 1	11530	0.11
chr1_26644827_26645344	0.26	UBXN11	UBX domain protein 11	231	0.76
chr22_17599001_17599302	0.25	CECR6	cat eye syndrome chromosome region, candidate 6	2992	0.19
chr8_134072568_134072719	0.25	SLA	Src-like-adaptor	40	0.98
chr4_148602160_148602311	0.25	PRMT10	protein arginine methyltransferase 10 (putative)	3041	0.27
chr1_175178431_175178668	0.24	KIAA0040	KIAA0040	16470	0.25
chr14_51288219_51288370	0.24	RP11-286O18.1		304	0.55
chr20_49136153_49136645	0.24	PTPN1	protein tyrosine phosphatase, non-receptor type 1	9479	0.17
chr3_113250860_113251011	0.24	SIDT1	SID1 transmembrane family, member 1	208	0.94
chr9_78639191_78639342	0.24	PCSK5	proprotein convertase subtilisin/kexin type 5	71627	0.13
chr20_33732797_33732980	0.24	EDEM2	ER degradation enhancer, mannosidase alpha-like 2	71	0.96
chr16_68306988_68307276	0.24	SLC7A6	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6	250	0.81
chr20_47441910_47442200	0.24	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	2365	0.4
chr18_43914231_43915043	0.24	RNF165	ring finger protein 165	450	0.89
chr19_41813133_41813284	0.24	CCDC97	coiled-coil domain containing 97	2886	0.15
chr2_7866064_7866235	0.23	ENSG00000221255	.	149177	0.05
chr8_27238127_27238372	0.23	PTK2B	protein tyrosine kinase 2 beta	81	0.98
chr18_67612600_67612814	0.23	CD226	CD226 molecule	1948	0.47
chr17_38018541_38018728	0.23	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1745	0.28
chr15_40745675_40745826	0.23	RP11-64K12.9		1088	0.32
chr5_118676780_118676931	0.23	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	7985	0.22
chr15_85141845_85142241	0.23	ZSCAN2	zinc finger and SCAN domain containing 2	2174	0.19
chr11_75081153_75081345	0.23	ARRB1	arrestin, beta 1	18376	0.12
chr19_47611961_47612112	0.23	SAE1	SUMO1 activating enzyme subunit 1	4495	0.17
chr16_88768022_88768436	0.23	RNF166	ring finger protein 166	1218	0.22
chr13_41579433_41579584	0.23	ELF1	E74-like factor 1 (ets domain transcription factor)	13942	0.19
chr3_30653748_30654209	0.23	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	5885	0.32
chr4_169680634_169680785	0.23	PALLD	palladin, cytoskeletal associated protein	47399	0.14
chr13_41372571_41372761	0.23	SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	5372	0.18
chr5_39176975_39177210	0.23	FYB	FYN binding protein	26037	0.23
chr1_55678186_55678720	0.23	USP24	ubiquitin specific peptidase 24	2309	0.34
chr1_114413652_114413958	0.23	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	515	0.69
chr5_133446207_133446358	0.23	TCF7	transcription factor 7 (T-cell specific, HMG-box)	4120	0.26
chr5_40683713_40683958	0.23	PTGER4	prostaglandin E receptor 4 (subtype EP4)	4235	0.24
chr1_36923329_36923682	0.23	MRPS15	mitochondrial ribosomal protein S15	6533	0.14
chr5_99606023_99606303	0.23	ENSG00000207077	.	116787	0.07
chr3_150324103_150324270	0.23	SELT	Selenoprotein T	3063	0.23
chr8_29954088_29954370	0.23	LEPROTL1	leptin receptor overlapping transcript-like 1	1064	0.45
chr8_75201254_75201405	0.23	JPH1	junctophilin 1	32234	0.16
chr4_154354700_154355154	0.22	KIAA0922	KIAA0922	32571	0.17
chr12_113416849_113417235	0.22	OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	697	0.66
chr17_73840046_73840332	0.22	UNC13D	unc-13 homolog D (C. elegans)	226	0.84
chr15_67390777_67391884	0.22	SMAD3	SMAD family member 3	313	0.93
chr5_156698426_156698828	0.22	CYFIP2	cytoplasmic FMR1 interacting protein 2	2265	0.23
chr16_68318190_68318689	0.22	ENSG00000252026	.	218	0.84
chr3_18767122_18767494	0.22	ENSG00000228956	.	19928	0.29
chr17_73064038_73064189	0.22	SLC16A5	solute carrier family 16 (monocarboxylate transporter), member 5	19709	0.07
chr10_126428666_126428902	0.22	FAM53B	family with sequence similarity 53, member B	2755	0.24
chr14_22947996_22948147	0.22	ENSG00000251002	.	2207	0.16
chr5_75839071_75839222	0.22	IQGAP2	IQ motif containing GTPase activating protein 2	4088	0.29
chr6_10529624_10529892	0.22	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	1169	0.49
chrX_42793717_42793868	0.22	MAOA	monoamine oxidase A	721675	0.0
chr3_142227777_142228000	0.22	RP11-383G6.3		36709	0.13
chr6_150954320_150954515	0.22	RP11-136K14.2		8604	0.22
chr19_35492875_35493026	0.21	GRAMD1A	GRAM domain containing 1A	1590	0.22
chr12_51019673_51019824	0.21	ENSG00000207136	.	7308	0.22
chr5_171601000_171601151	0.21	STK10	serine/threonine kinase 10	14315	0.19
chr9_128586328_128586530	0.21	PBX3	pre-B-cell leukemia homeobox 3	41121	0.2
chr16_50776896_50777610	0.21	RP11-327F22.1		527	0.39
chr6_30798000_30798388	0.21	ENSG00000202241	.	33833	0.07
chr2_192058733_192058884	0.21	STAT4	signal transducer and activator of transcription 4	42486	0.15
chr15_70851080_70851231	0.21	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	143465	0.05
chr17_75663137_75663644	0.21	SEPT9	septin 9	185395	0.03
chr20_13228054_13228205	0.21	RP5-1077I2.3		2113	0.33
chr17_66352660_66353063	0.21	ARSG	arylsulfatase G	65202	0.09
chr2_198131130_198131281	0.21	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	36038	0.14
chr21_16507528_16507679	0.21	NRIP1	nuclear receptor interacting protein 1	70282	0.13
chr14_65165620_65165918	0.21	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	5051	0.25
chr14_22966536_22967037	0.21	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	10615	0.1
chr8_11663519_11663931	0.21	FDFT1	farnesyl-diphosphate farnesyltransferase 1	1727	0.27
chr18_43784563_43784787	0.21	C18orf25	chromosome 18 open reading frame 25	30675	0.18
chr5_100067523_100067876	0.21	ENSG00000207269	.	1063	0.67
chr7_50348888_50349341	0.21	IKZF1	IKAROS family zinc finger 1 (Ikaros)	796	0.76
chr6_135409102_135409253	0.20	HBS1L	HBS1-like (S. cerevisiae)	15017	0.21
chr9_139635971_139636180	0.20	LCN10	lipocalin 10	1280	0.21
chr13_108457167_108457318	0.20	FAM155A-IT1	FAM155A intronic transcript 1 (non-protein coding)	30557	0.22
chr15_40599321_40599893	0.20	PLCB2	phospholipase C, beta 2	419	0.68
chr9_134603422_134603972	0.20	ENSG00000240853	.	2843	0.28
chr14_91833633_91833915	0.20	ENSG00000265856	.	33717	0.17
chr2_235397304_235397485	0.20	ARL4C	ADP-ribosylation factor-like 4C	7850	0.33
chr15_75072904_75073055	0.20	CSK	c-src tyrosine kinase	1419	0.29
chr18_67565113_67565264	0.20	CD226	CD226 molecule	49467	0.18
chr3_3234132_3234283	0.20	CRBN	cereblon	12813	0.2
chr17_7462231_7462382	0.20	TNFSF13	tumor necrosis factor (ligand) superfamily, member 13	202	0.78
chr14_102342635_102343008	0.20	PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	7053	0.2
chr6_108489604_108489769	0.20	NR2E1	nuclear receptor subfamily 2, group E, member 1	281	0.9
chr5_67551667_67551899	0.20	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	16057	0.26
chr22_19792659_19792810	0.20	TBX1	T-box 1	48508	0.1
chr19_8274834_8275489	0.20	CERS4	ceramide synthase 4	643	0.68
chr9_7935667_7935818	0.20	TMEM261	transmembrane protein 261	135675	0.06
chr3_15578534_15578685	0.20	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	15351	0.14
chrX_144503620_144503771	0.20	SPANXN1	SPANX family, member N1	175347	0.03
chr7_26192485_26193339	0.20	NFE2L3	nuclear factor, erythroid 2-like 3	1052	0.53
chr22_50524316_50524467	0.20	MLC1	megalencephalic leukoencephalopathy with subcortical cysts 1	60	0.96
chr20_31116427_31116578	0.20	C20orf112	chromosome 20 open reading frame 112	7698	0.18
chr17_72755530_72755949	0.20	SLC9A3R1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	2403	0.16
chr8_130983839_130984300	0.20	FAM49B	family with sequence similarity 49, member B	833	0.63
chr21_43844485_43844636	0.20	ENSG00000252619	.	6858	0.14
chr11_3880339_3880818	0.19	STIM1	stromal interaction molecule 1	3166	0.13
chr5_40407299_40407450	0.19	ENSG00000265615	.	86954	0.1
chr3_31481429_31481580	0.19	ENSG00000238727	.	44075	0.19
chr12_125405924_125406261	0.19	UBC	ubiquitin C	4178	0.19
chr4_38511545_38511706	0.19	RP11-617D20.1		114571	0.06
chr2_139211862_139212013	0.19	SPOPL	speckle-type POZ protein-like	47434	0.2
chr10_30818638_30818892	0.19	ENSG00000239744	.	26068	0.21
chr15_64795611_64796094	0.19	ZNF609	zinc finger protein 609	4361	0.19
chr16_50780900_50781420	0.19	CYLD	cylindromatosis (turban tumor syndrome)	2300	0.18
chr6_11330937_11331205	0.19	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	51461	0.16
chr2_235362717_235362976	0.19	ARL4C	ADP-ribosylation factor-like 4C	42398	0.22
chr9_115918189_115918351	0.19	SLC31A2	solute carrier family 31 (copper transporter), member 2	5048	0.23
chr1_54751269_54751420	0.19	RP5-997D24.3		266	0.91
chr5_134761441_134761660	0.19	C5orf20	chromosome 5 open reading frame 20	21488	0.12
chr20_35258352_35258894	0.19	SLA2	Src-like-adaptor 2	15661	0.12
chr7_2738603_2738843	0.19	AMZ1	archaelysin family metallopeptidase 1	10887	0.21
chr11_67038920_67039071	0.19	ADRBK1	adrenergic, beta, receptor kinase 1	5043	0.13
chr17_75451832_75452118	0.19	SEPT9	septin 9	473	0.77
chr6_90145242_90145393	0.19	ANKRD6	ankyrin repeat domain 6	2385	0.29
chrX_4209642_4209793	0.19	ENSG00000264861	.	291824	0.01
chr6_22221737_22221888	0.19	RP3-404K8.2		38841	0.2
chr16_57577463_57577729	0.19	GPR114	G protein-coupled receptor 114	995	0.47
chr20_55975682_55975833	0.19	RP4-800J21.3		7639	0.16
chr5_43037958_43038653	0.19	AC025171.1		3372	0.18
chr1_150976711_150976969	0.19	FAM63A	family with sequence similarity 63, member A	2121	0.14
chrX_96855091_96855242	0.19	DIAPH2-AS1	DIAPH2 antisense RNA 1	17092	0.31
chr10_14603489_14603761	0.19	FAM107B	family with sequence similarity 107, member B	5446	0.27
chr15_70550912_70551174	0.19	ENSG00000200216	.	65468	0.14
chr3_128717575_128717726	0.18	EFCC1	EF-hand and coiled-coil domain containing 1	2822	0.2
chr10_6585169_6585583	0.18	PRKCQ	protein kinase C, theta	36825	0.22
chr4_2283428_2283729	0.18	ZFYVE28	zinc finger, FYVE domain containing 28	5864	0.13
chr12_104855264_104855415	0.18	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	4560	0.31
chr2_99346083_99347252	0.18	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	44	0.98
chr12_32639229_32639410	0.18	FGD4	FYVE, RhoGEF and PH domain containing 4	413	0.87
chr17_65822638_65823477	0.18	BPTF	bromodomain PHD finger transcription factor	799	0.61
chr16_53552293_53552836	0.18	AKTIP	AKT interacting protein	14241	0.21
chr10_3917179_3917448	0.18	KLF6	Kruppel-like factor 6	89840	0.09
chr1_19253687_19254204	0.18	IFFO2	intermediate filament family orphan 2	15459	0.16
chr1_16470894_16471177	0.18	RP11-276H7.2		10671	0.12
chr7_107201320_107201637	0.18	COG5	component of oligomeric golgi complex 5	2901	0.18
chr21_36412378_36412763	0.18	RUNX1	runt-related transcription factor 1	8892	0.33
chr4_84029715_84029866	0.18	PLAC8	placenta-specific 8	1206	0.55
chr2_182170467_182170618	0.18	ENSG00000266705	.	163	0.98
chr10_666285_666436	0.18	RP11-809C18.3		8218	0.17
chr7_50306566_50306717	0.18	IKZF1	IKAROS family zinc finger 1 (Ikaros)	37683	0.2
chr2_25704888_25705039	0.18	AC104699.1		60977	0.13
chr22_37544094_37544245	0.18	IL2RB	interleukin 2 receptor, beta	1861	0.22
chr18_77161034_77161555	0.18	NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	902	0.67
chr20_43598945_43599305	0.18	STK4	serine/threonine kinase 4	3958	0.17
chr5_176784624_176784924	0.18	RGS14	regulator of G-protein signaling 14	64	0.95
chr13_51287948_51288226	0.17	DLEU7-AS1	DLEU7 antisense RNA 1	93905	0.08
chr16_31365954_31366231	0.17	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	363	0.8
chr7_7960484_7960678	0.17	ENSG00000201747	.	14431	0.18
chr16_50778328_50778504	0.17	RP11-327F22.1		1690	0.19
chr16_10940725_10940876	0.17	TVP23A	trans-golgi network vesicle protein 23 homolog A (S. cerevisiae)	28158	0.13
chr2_44347613_44347791	0.17	ENSG00000252599	.	34332	0.15
chr7_116712743_116713170	0.17	ST7-AS2	ST7 antisense RNA 2	1822	0.35
chr14_70161983_70162134	0.17	SRSF5	serine/arginine-rich splicing factor 5	31559	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.3	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.1	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.1	0.3	GO:0051024	positive regulation of immunoglobulin secretion(GO:0051024)
0.1	0.2	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.3	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.1	0.2	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.3	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.1	0.2	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.0	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.2	GO:0045911	positive regulation of isotype switching(GO:0045830) positive regulation of DNA recombination(GO:0045911)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.2	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.4	GO:0031648	protein destabilization(GO:0031648)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.2	GO:0001787	natural killer cell proliferation(GO:0001787)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.3	GO:0036230	granulocyte activation(GO:0036230)
0.0	0.1	GO:0002423	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.0	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.1	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.2	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.0	GO:0070293	renal absorption(GO:0070293)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:1903960	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.0	GO:0015911	plasma membrane long-chain fatty acid transport(GO:0015911)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.5	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.2	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.1	GO:0002639	positive regulation of immunoglobulin production(GO:0002639)
0.0	0.1	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.0	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:1901798	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0042695	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.0	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0003057	regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0	0.2	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.0	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.1	GO:0045655	regulation of monocyte differentiation(GO:0045655)
0.0	0.0	GO:0046543	development of secondary female sexual characteristics(GO:0046543)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.0	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.0	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.1	GO:0050655	dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.0	0.0	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0	0.1	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.3	GO:0007032	endosome organization(GO:0007032)
0.0	0.0	GO:0045410	positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0	0.1	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0	0.0	GO:0055022	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.0	GO:0010826	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.1	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.2	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.0	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.0	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.0	0.0	GO:0045136	development of secondary sexual characteristics(GO:0045136)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.2	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.0	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.0	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.0	GO:0010922	positive regulation of phosphatase activity(GO:0010922) positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0009136	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.1	GO:0006825	copper ion transport(GO:0006825)
0.0	0.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0007549	dosage compensation(GO:0007549)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.0	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.0	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0	0.1	GO:2000399	negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399)
0.0	0.1	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.1	GO:0032367	intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367)
0.0	0.0	GO:0048570	notochord morphogenesis(GO:0048570)
0.0	0.0	GO:0009648	photoperiodism(GO:0009648)
0.0	0.0	GO:0002068	glandular epithelial cell development(GO:0002068)
0.0	0.1	GO:0061756	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.0	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.4	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0001914	regulation of T cell mediated cytotoxicity(GO:0001914)
0.0	0.0	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0000303	response to superoxide(GO:0000303)
0.0	0.1	GO:1901224	activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:1901862	negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
0.0	0.2	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0048867	stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.0	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0097031	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.2	GO:0016925	protein sumoylation(GO:0016925)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.2	GO:0090630	activation of GTPase activity(GO:0090630)
0.0	0.0	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.0	GO:0002836	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.0	GO:0002709	regulation of T cell mediated immunity(GO:0002709)
0.0	0.0	GO:0050665	hydrogen peroxide biosynthetic process(GO:0050665)
0.0	0.0	GO:0043501	skeletal muscle adaptation(GO:0043501)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0018208	peptidyl-proline modification(GO:0018208)
0.0	0.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.0	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.0	GO:0090382	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:2001021	negative regulation of response to DNA damage stimulus(GO:2001021)
0.0	0.3	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:0055075	potassium ion homeostasis(GO:0055075)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	0.4	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.2	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.0	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.0	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.0	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.0	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0000299	obsolete integral to membrane of membrane fraction(GO:0000299)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	0.0	GO:0038201	TORC1 complex(GO:0031931) TOR complex(GO:0038201)
0.0	0.3	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.0	GO:0032009	early phagosome(GO:0032009)
0.0	0.0	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.3	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.2	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.5	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.1	0.7	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	0.2	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.3	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.3	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.2	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.3	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.3	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.3	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.5	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.4	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.3	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.5	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.2	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.2	GO:0043499	obsolete eukaryotic cell surface binding(GO:0043499)
0.0	0.1	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.0	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0	0.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.0	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.0	GO:0051734	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.0	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.0	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.0	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.6	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.4	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.0	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.4	GO:0036459	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.0	GO:0046978	TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.0	GO:0001848	complement binding(GO:0001848)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.0	GO:0002060	purine nucleobase binding(GO:0002060)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.7	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.3	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.4	PID TRAIL PATHWAY	TRAIL signaling pathway
0.4	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.7	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.3	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.1	PID EPO PATHWAY	EPO signaling pathway
0.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.0	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.2	PID CXCR3 PATHWAY	CXCR3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	0.6	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	0.7	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.0	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.0	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.6	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.1	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.0	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.0	0.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.0	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.0	0.3	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.1	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.0	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.1	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.1	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0	0.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI