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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for RUNX3_BCL11A

Z-value: 1.28

Motif logo

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Transcription factors associated with RUNX3_BCL11A

Gene Symbol Gene ID Gene Info
RUNX3
ENSG00000020633.14 RUNX family transcription factor 3
BCL11A
ENSG00000119866.16 BAF chromatin remodeling complex subunit BCL11A

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr2_60784499_60784860BCL11A39770.2896310.872.1e-03Click!
chr2_60756957_60757205BCL11A234590.1993340.827.0e-03Click!
chr2_60783649_60784435BCL11A33400.3083080.617.8e-02Click!
chr2_60757710_60758018BCL11A226760.2017630.551.3e-01Click!
chr2_60774340_60774491BCL11A61250.2583080.491.8e-01Click!
chr1_25247095_25247246RUNX384420.232048-0.617.9e-02Click!
chr1_25253994_25254145RUNX315430.4484900.608.8e-02Click!
chr1_25252382_25252533RUNX331550.2924040.609.1e-02Click!
chr1_25255138_25255978RUNX3540.9804030.581.0e-01Click!
chr1_25252115_25252332RUNX333890.2838510.571.1e-01Click!

Activity of the RUNX3_BCL11A motif across conditions

Conditions sorted by the z-value of the RUNX3_BCL11A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr10_116285976_116286984 0.64 ABLIM1
 actin binding LIM protein 1
 114
 0.98
chr14_91882732_91883366 0.50 CCDC88C
 coiled-coil domain containing 88C
 641
 0.78
chr12_2800154_2801438 0.48 CACNA1C-AS1
 CACNA1C antisense RNA 1
 430
 0.83
chrX_12974492_12974668 0.44 TMSB4X
 thymosin beta 4, X-linked
 18647
 0.19
chr1_1148809_1149188 0.43 TNFRSF4
 tumor necrosis factor receptor superfamily, member 4
 514
 0.56
chr21_40139305_40139870 0.42 ETS2
 v-ets avian erythroblastosis virus E26 oncogene homolog 2
 37644
 0.21
chr19_39029395_39029671 0.42 AC067969.2
1765
 0.24
chr2_173327465_173327877 0.41 AC078883.3
3069
 0.24
chr9_116635130_116635281 0.39 ZNF618
 zinc finger protein 618
 3357
 0.34
chr16_85649875_85650315 0.39 GSE1
 Gse1 coiled-coil protein
 3137
 0.26
chr2_191929470_191929872 0.38 ENSG00000231858
 .
 43419
 0.12
chr4_84034184_84034613 0.36 PLAC8
 placenta-specific 8
 1470
 0.48
chr19_13215586_13215874 0.35 LYL1
 lymphoblastic leukemia derived sequence 1
 1755
 0.21
chr14_92301921_92302175 0.34 TC2N
 tandem C2 domains, nuclear
 736
 0.7
chr12_47609308_47609580 0.34 PCED1B
 PC-esterase domain containing 1B
 608
 0.77
chr19_16477276_16478284 0.34 EPS15L1
 epidermal growth factor receptor pathway substrate 15-like 1
 5016
 0.17
chr3_39402780_39403041 0.34 SLC25A38
 solute carrier family 25, member 38
 21929
 0.13
chr5_39203555_39203988 0.32 FYB
 FYN binding protein
 642
 0.81
chr13_41707065_41707565 0.32 KBTBD6
 kelch repeat and BTB (POZ) domain containing 6
 433
 0.79
chr9_92092302_92093120 0.32 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 2094
 0.37
chr20_8194475_8194883 0.31 PLCB1-IT1
 PLCB1 intronic transcript 1 (non-protein coding)
 34672
 0.21
chr19_42703347_42703984 0.31 ENSG00000265122
 .
 6435
 0.1
chr17_29640754_29641122 0.31 EVI2B
 ecotropic viral integration site 2B
 164
 0.93
chrX_57313067_57313960 0.31 FAAH2
 fatty acid amide hydrolase 2
 374
 0.92
chr1_117301083_117301385 0.30 CD2
 CD2 molecule
 4145
 0.26
chrX_118815979_118816490 0.30 SEPT6
 septin 6
 10558
 0.17
chr16_29674660_29674967 0.30 QPRT
 quinolinate phosphoribosyltransferase
 213
 0.51
chr12_109027255_109027564 0.30 SELPLG
 selectin P ligand
 261
 0.87
chrX_70842641_70842792 0.30 ENSG00000264855
 .
 2989
 0.24
chr1_232054576_232054868 0.29 DISC1-IT1
 DISC1 intronic transcript 1 (non-protein coding)
 6858
 0.32
chr16_88844628_88844779 0.29 PIEZO1
 piezo-type mechanosensitive ion channel component 1
 6916
 0.09
chr1_85328555_85328706 0.29 LPAR3
 lysophosphatidic acid receptor 3
 3212
 0.32
chr1_117298667_117299007 0.28 CD2
 CD2 molecule
 1748
 0.4
chr2_202097823_202098101 0.28 CASP8
 caspase 8, apoptosis-related cysteine peptidase
 204
 0.94
chr5_75700712_75700863 0.28 IQGAP2
 IQ motif containing GTPase activating protein 2
 538
 0.86
chrX_129225814_129226276 0.28 ELF4
 E74-like factor 4 (ets domain transcription factor)
 18291
 0.19
chr12_10021470_10021931 0.28 CLEC2B
 C-type lectin domain family 2, member B
 1035
 0.4
chr2_54809030_54809206 0.27 SPTBN1
 spectrin, beta, non-erythrocytic 1
 23587
 0.17
chr1_209941174_209941325 0.27 TRAF3IP3
 TRAF3 interacting protein 3
 584
 0.67
chr13_114549320_114549471 0.27 GAS6
 growth arrest-specific 6
 661
 0.76
chr14_71465889_71466177 0.26 PCNX
 pecanex homolog (Drosophila)
 13715
 0.29
chr2_158295494_158296053 0.26 CYTIP
 cytohesin 1 interacting protein
 153
 0.96
chr7_26333293_26333815 0.26 SNX10
 sorting nexin 10
 880
 0.67
chr20_47439188_47439680 0.26 PREX1
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
 4986
 0.3
chr9_131831774_131831925 0.26 DOLPP1
 dolichyldiphosphatase 1
 11530
 0.11
chr1_26644827_26645344 0.26 UBXN11
 UBX domain protein 11
 231
 0.76
chr22_17599001_17599302 0.25 CECR6
 cat eye syndrome chromosome region, candidate 6
 2992
 0.19
chr8_134072568_134072719 0.25 SLA
 Src-like-adaptor
 40
 0.98
chr4_148602160_148602311 0.25 PRMT10
 protein arginine methyltransferase 10 (putative)
 3041
 0.27
chr1_175178431_175178668 0.24 KIAA0040
 KIAA0040
 16470
 0.25
chr14_51288219_51288370 0.24 RP11-286O18.1
304
 0.55
chr20_49136153_49136645 0.24 PTPN1
 protein tyrosine phosphatase, non-receptor type 1
 9479
 0.17
chr3_113250860_113251011 0.24 SIDT1
 SID1 transmembrane family, member 1
 208
 0.94
chr9_78639191_78639342 0.24 PCSK5
 proprotein convertase subtilisin/kexin type 5
 71627
 0.13
chr20_33732797_33732980 0.24 EDEM2
 ER degradation enhancer, mannosidase alpha-like 2
 71
 0.96
chr16_68306988_68307276 0.24 SLC7A6
 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
 250
 0.81
chr20_47441910_47442200 0.24 PREX1
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
 2365
 0.4
chr18_43914231_43915043 0.24 RNF165
 ring finger protein 165
 450
 0.89
chr19_41813133_41813284 0.24 CCDC97
 coiled-coil domain containing 97
 2886
 0.15
chr2_7866064_7866235 0.23 ENSG00000221255
 .
 149177
 0.05
chr8_27238127_27238372 0.23 PTK2B
 protein tyrosine kinase 2 beta
 81
 0.98
chr18_67612600_67612814 0.23 CD226
 CD226 molecule
 1948
 0.47
chr17_38018541_38018728 0.23 IKZF3
 IKAROS family zinc finger 3 (Aiolos)
 1745
 0.28
chr15_40745675_40745826 0.23 RP11-64K12.9
1088
 0.32
chr5_118676780_118676931 0.23 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 7985
 0.22
chr15_85141845_85142241 0.23 ZSCAN2
 zinc finger and SCAN domain containing 2
 2174
 0.19
chr11_75081153_75081345 0.23 ARRB1
 arrestin, beta 1
 18376
 0.12
chr19_47611961_47612112 0.23 SAE1
 SUMO1 activating enzyme subunit 1
 4495
 0.17
chr16_88768022_88768436 0.23 RNF166
 ring finger protein 166
 1218
 0.22
chr13_41579433_41579584 0.23 ELF1
 E74-like factor 1 (ets domain transcription factor)
 13942
 0.19
chr3_30653748_30654209 0.23 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 5885
 0.32
chr4_169680634_169680785 0.23 PALLD
 palladin, cytoskeletal associated protein
 47399
 0.14
chr13_41372571_41372761 0.23 SLC25A15
 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
 5372
 0.18
chr5_39176975_39177210 0.23 FYB
 FYN binding protein
 26037
 0.23
chr1_55678186_55678720 0.23 USP24
 ubiquitin specific peptidase 24
 2309
 0.34
chr1_114413652_114413958 0.23 PTPN22
 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
 515
 0.69
chr5_133446207_133446358 0.23 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 4120
 0.26
chr5_40683713_40683958 0.23 PTGER4
 prostaglandin E receptor 4 (subtype EP4)
 4235
 0.24
chr1_36923329_36923682 0.23 MRPS15
 mitochondrial ribosomal protein S15
 6533
 0.14
chr5_99606023_99606303 0.23 ENSG00000207077
 .
 116787
 0.07
chr3_150324103_150324270 0.23 SELT
 Selenoprotein T
 3063
 0.23
chr8_29954088_29954370 0.23 LEPROTL1
 leptin receptor overlapping transcript-like 1
 1064
 0.45
chr8_75201254_75201405 0.23 JPH1
 junctophilin 1
 32234
 0.16
chr4_154354700_154355154 0.22 KIAA0922
 KIAA0922
 32571
 0.17
chr12_113416849_113417235 0.22 OAS2
 2'-5'-oligoadenylate synthetase 2, 69/71kDa
 697
 0.66
chr17_73840046_73840332 0.22 UNC13D
 unc-13 homolog D (C. elegans)
 226
 0.84
chr15_67390777_67391884 0.22 SMAD3
 SMAD family member 3
 313
 0.93
chr5_156698426_156698828 0.22 CYFIP2
 cytoplasmic FMR1 interacting protein 2
 2265
 0.23
chr16_68318190_68318689 0.22 ENSG00000252026
 .
 218
 0.84
chr3_18767122_18767494 0.22 ENSG00000228956
 .
 19928
 0.29
chr17_73064038_73064189 0.22 SLC16A5
 solute carrier family 16 (monocarboxylate transporter), member 5
 19709
 0.07
chr10_126428666_126428902 0.22 FAM53B
 family with sequence similarity 53, member B
 2755
 0.24
chr14_22947996_22948147 0.22 ENSG00000251002
 .
 2207
 0.16
chr5_75839071_75839222 0.22 IQGAP2
 IQ motif containing GTPase activating protein 2
 4088
 0.29
chr6_10529624_10529892 0.22 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
 1169
 0.49
chrX_42793717_42793868 0.22 MAOA
 monoamine oxidase A
 721675
 0.0
chr3_142227777_142228000 0.22 RP11-383G6.3
36709
 0.13
chr6_150954320_150954515 0.22 RP11-136K14.2
8604
 0.22
chr19_35492875_35493026 0.21 GRAMD1A
 GRAM domain containing 1A
 1590
 0.22
chr12_51019673_51019824 0.21 ENSG00000207136
 .
 7308
 0.22
chr5_171601000_171601151 0.21 STK10
 serine/threonine kinase 10
 14315
 0.19
chr9_128586328_128586530 0.21 PBX3
 pre-B-cell leukemia homeobox 3
 41121
 0.2
chr16_50776896_50777610 0.21 RP11-327F22.1
527
 0.39
chr6_30798000_30798388 0.21 ENSG00000202241
 .
 33833
 0.07
chr2_192058733_192058884 0.21 STAT4
 signal transducer and activator of transcription 4
 42486
 0.15
chr15_70851080_70851231 0.21 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 143465
 0.05
chr17_75663137_75663644 0.21 SEPT9
 septin 9
 185395
 0.03
chr20_13228054_13228205 0.21 RP5-1077I2.3
2113
 0.33
chr17_66352660_66353063 0.21 ARSG
 arylsulfatase G
 65202
 0.09
chr2_198131130_198131281 0.21 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 36038
 0.14
chr21_16507528_16507679 0.21 NRIP1
 nuclear receptor interacting protein 1
 70282
 0.13
chr14_65165620_65165918 0.21 PLEKHG3
 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
 5051
 0.25
chr14_22966536_22967037 0.21 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 10615
 0.1
chr8_11663519_11663931 0.21 FDFT1
 farnesyl-diphosphate farnesyltransferase 1
 1727
 0.27
chr18_43784563_43784787 0.21 C18orf25
 chromosome 18 open reading frame 25
 30675
 0.18
chr5_100067523_100067876 0.21 ENSG00000207269
 .
 1063
 0.67
chr7_50348888_50349341 0.21 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 796
 0.76
chr6_135409102_135409253 0.20 HBS1L
 HBS1-like (S. cerevisiae)
 15017
 0.21
chr9_139635971_139636180 0.20 LCN10
 lipocalin 10
 1280
 0.21
chr13_108457167_108457318 0.20 FAM155A-IT1
 FAM155A intronic transcript 1 (non-protein coding)
 30557
 0.22
chr15_40599321_40599893 0.20 PLCB2
 phospholipase C, beta 2
 419
 0.68
chr9_134603422_134603972 0.20 ENSG00000240853
 .
 2843
 0.28
chr14_91833633_91833915 0.20 ENSG00000265856
 .
 33717
 0.17
chr2_235397304_235397485 0.20 ARL4C
 ADP-ribosylation factor-like 4C
 7850
 0.33
chr15_75072904_75073055 0.20 CSK
 c-src tyrosine kinase
 1419
 0.29
chr18_67565113_67565264 0.20 CD226
 CD226 molecule
 49467
 0.18
chr3_3234132_3234283 0.20 CRBN
 cereblon
 12813
 0.2
chr17_7462231_7462382 0.20 TNFSF13
 tumor necrosis factor (ligand) superfamily, member 13
 202
 0.78
chr14_102342635_102343008 0.20 PPP2R5C
 protein phosphatase 2, regulatory subunit B', gamma
 7053
 0.2
chr6_108489604_108489769 0.20 NR2E1
 nuclear receptor subfamily 2, group E, member 1
 281
 0.9
chr5_67551667_67551899 0.20 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 16057
 0.26
chr22_19792659_19792810 0.20 TBX1
 T-box 1
 48508
 0.1
chr19_8274834_8275489 0.20 CERS4
 ceramide synthase 4
 643
 0.68
chr9_7935667_7935818 0.20 TMEM261
 transmembrane protein 261
 135675
 0.06
chr3_15578534_15578685 0.20 COLQ
 collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
 15351
 0.14
chrX_144503620_144503771 0.20 SPANXN1
 SPANX family, member N1
 175347
 0.03
chr7_26192485_26193339 0.20 NFE2L3
 nuclear factor, erythroid 2-like 3
 1052
 0.53
chr22_50524316_50524467 0.20 MLC1
 megalencephalic leukoencephalopathy with subcortical cysts 1
 60
 0.96
chr20_31116427_31116578 0.20 C20orf112
 chromosome 20 open reading frame 112
 7698
 0.18
chr17_72755530_72755949 0.20 SLC9A3R1
 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
 2403
 0.16
chr8_130983839_130984300 0.20 FAM49B
 family with sequence similarity 49, member B
 833
 0.63
chr21_43844485_43844636 0.20 ENSG00000252619
 .
 6858
 0.14
chr11_3880339_3880818 0.19 STIM1
 stromal interaction molecule 1
 3166
 0.13
chr5_40407299_40407450 0.19 ENSG00000265615
 .
 86954
 0.1
chr3_31481429_31481580 0.19 ENSG00000238727
 .
 44075
 0.19
chr12_125405924_125406261 0.19 UBC
 ubiquitin C
 4178
 0.19
chr4_38511545_38511706 0.19 RP11-617D20.1
114571
 0.06
chr2_139211862_139212013 0.19 SPOPL
 speckle-type POZ protein-like
 47434
 0.2
chr10_30818638_30818892 0.19 ENSG00000239744
 .
 26068
 0.21
chr15_64795611_64796094 0.19 ZNF609
 zinc finger protein 609
 4361
 0.19
chr16_50780900_50781420 0.19 CYLD
 cylindromatosis (turban tumor syndrome)
 2300
 0.18
chr6_11330937_11331205 0.19 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 51461
 0.16
chr2_235362717_235362976 0.19 ARL4C
 ADP-ribosylation factor-like 4C
 42398
 0.22
chr9_115918189_115918351 0.19 SLC31A2
 solute carrier family 31 (copper transporter), member 2
 5048
 0.23
chr1_54751269_54751420 0.19 RP5-997D24.3
266
 0.91
chr5_134761441_134761660 0.19 C5orf20
 chromosome 5 open reading frame 20
 21488
 0.12
chr20_35258352_35258894 0.19 SLA2
 Src-like-adaptor 2
 15661
 0.12
chr7_2738603_2738843 0.19 AMZ1
 archaelysin family metallopeptidase 1
 10887
 0.21
chr11_67038920_67039071 0.19 ADRBK1
 adrenergic, beta, receptor kinase 1
 5043
 0.13
chr17_75451832_75452118 0.19 SEPT9
 septin 9
 473
 0.77
chr6_90145242_90145393 0.19 ANKRD6
 ankyrin repeat domain 6
 2385
 0.29
chrX_4209642_4209793 0.19 ENSG00000264861
 .
 291824
 0.01
chr6_22221737_22221888 0.19 RP3-404K8.2
38841
 0.2
chr16_57577463_57577729 0.19 GPR114
 G protein-coupled receptor 114
 995
 0.47
chr20_55975682_55975833 0.19 RP4-800J21.3
7639
 0.16
chr5_43037958_43038653 0.19 AC025171.1
3372
 0.18
chr1_150976711_150976969 0.19 FAM63A
 family with sequence similarity 63, member A
 2121
 0.14
chrX_96855091_96855242 0.19 DIAPH2-AS1
 DIAPH2 antisense RNA 1
 17092
 0.31
chr10_14603489_14603761 0.19 FAM107B
 family with sequence similarity 107, member B
 5446
 0.27
chr15_70550912_70551174 0.19 ENSG00000200216
 .
 65468
 0.14
chr3_128717575_128717726 0.18 EFCC1
 EF-hand and coiled-coil domain containing 1
 2822
 0.2
chr10_6585169_6585583 0.18 PRKCQ
 protein kinase C, theta
 36825
 0.22
chr4_2283428_2283729 0.18 ZFYVE28
 zinc finger, FYVE domain containing 28
 5864
 0.13
chr12_104855264_104855415 0.18 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 4560
 0.31
chr2_99346083_99347252 0.18 MGAT4A
 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
 44
 0.98
chr12_32639229_32639410 0.18 FGD4
 FYVE, RhoGEF and PH domain containing 4
 413
 0.87
chr17_65822638_65823477 0.18 BPTF
 bromodomain PHD finger transcription factor
 799
 0.61
chr16_53552293_53552836 0.18 AKTIP
 AKT interacting protein
 14241
 0.21
chr10_3917179_3917448 0.18 KLF6
 Kruppel-like factor 6
 89840
 0.09
chr1_19253687_19254204 0.18 IFFO2
 intermediate filament family orphan 2
 15459
 0.16
chr1_16470894_16471177 0.18 RP11-276H7.2
10671
 0.12
chr7_107201320_107201637 0.18 COG5
 component of oligomeric golgi complex 5
 2901
 0.18
chr21_36412378_36412763 0.18 RUNX1
 runt-related transcription factor 1
 8892
 0.33
chr4_84029715_84029866 0.18 PLAC8
 placenta-specific 8
 1206
 0.55
chr2_182170467_182170618 0.18 ENSG00000266705
 .
 163
 0.98
chr10_666285_666436 0.18 RP11-809C18.3
8218
 0.17
chr7_50306566_50306717 0.18 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 37683
 0.2
chr2_25704888_25705039 0.18 AC104699.1
60977
 0.13
chr22_37544094_37544245 0.18 IL2RB
 interleukin 2 receptor, beta
 1861
 0.22
chr18_77161034_77161555 0.18 NFATC1
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
 902
 0.67
chr20_43598945_43599305 0.18 STK4
 serine/threonine kinase 4
 3958
 0.17
chr5_176784624_176784924 0.18 RGS14
 regulator of G-protein signaling 14
 64
 0.95
chr13_51287948_51288226 0.17 DLEU7-AS1
 DLEU7 antisense RNA 1
 93905
 0.08
chr16_31365954_31366231 0.17 ITGAX
 integrin, alpha X (complement component 3 receptor 4 subunit)
 363
 0.8
chr7_7960484_7960678 0.17 ENSG00000201747
 .
 14431
 0.18
chr16_50778328_50778504 0.17 RP11-327F22.1
1690
 0.19
chr16_10940725_10940876 0.17 TVP23A
 trans-golgi network vesicle protein 23 homolog A (S. cerevisiae)
 28158
 0.13
chr2_44347613_44347791 0.17 ENSG00000252599
 .
 34332
 0.15
chr7_116712743_116713170 0.17 ST7-AS2
 ST7 antisense RNA 2
 1822
 0.35
chr14_70161983_70162134 0.17 SRSF5
 serine/arginine-rich splicing factor 5
 31559
 0.19

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1 0.3 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.1 0.1 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.1 0.3 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)
0.1 0.2 GO:0051834 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.3 GO:0071354 cellular response to interleukin-6(GO:0071354)
0.1 0.2 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.3 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 0.2 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.1 GO:0010957 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.0 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.3 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.2 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.2 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.2 GO:0045911 positive regulation of isotype switching(GO:0045830) positive regulation of DNA recombination(GO:0045911)
0.0 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.2 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.4 GO:0031648 protein destabilization(GO:0031648)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.2 GO:0001787 natural killer cell proliferation(GO:0001787)
0.0 0.1 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:1904035 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.3 GO:0036230 granulocyte activation(GO:0036230)
0.0 0.1 GO:0002423 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.0 GO:0034393 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.1 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.1 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.2 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.0 GO:0070293 renal absorption(GO:0070293)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:2000143 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:1903960 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.0 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.0 GO:0015911 plasma membrane long-chain fatty acid transport(GO:0015911)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.5 GO:0008633 obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0 0.2 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.1 GO:0002639 positive regulation of immunoglobulin production(GO:0002639)
0.0 0.1 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.0 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:1901798 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.1 GO:0008049 male courtship behavior(GO:0008049)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0043276 anoikis(GO:0043276)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.0 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.0 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.1 GO:0051642 centrosome localization(GO:0051642)
0.0 0.1 GO:0003057 regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0 0.2 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.1 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.0 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.1 GO:0045655 regulation of monocyte differentiation(GO:0045655)
0.0 0.0 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.0 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.0 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.0 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0048548 regulation of pinocytosis(GO:0048548)
0.0 0.1 GO:0050655 dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.0 0.0 GO:0018243 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.0 GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0 0.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.3 GO:0007032 endosome organization(GO:0007032)
0.0 0.0 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0 0.1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0 0.0 GO:0055022 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0 0.0 GO:0010826 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0 0.1 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.0 0.0 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.0 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.0 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.0 GO:0045136 development of secondary sexual characteristics(GO:0045136)
0.0 0.1 GO:0045003 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.2 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.0 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.0 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.0 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.0 GO:0010922 positive regulation of phosphatase activity(GO:0010922) positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.1 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.1 GO:0006825 copper ion transport(GO:0006825)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.1 GO:0007549 dosage compensation(GO:0007549)
0.0 0.0 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.1 GO:0090322 regulation of superoxide metabolic process(GO:0090322)
0.0 0.0 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.0 GO:0030952 establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:2000399 negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399)
0.0 0.1 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.1 GO:0032367 intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367)
0.0 0.0 GO:0048570 notochord morphogenesis(GO:0048570)
0.0 0.0 GO:0009648 photoperiodism(GO:0009648)
0.0 0.0 GO:0002068 glandular epithelial cell development(GO:0002068)
0.0 0.1 GO:0061756 leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0 0.0 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.0 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.4 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.0 GO:0001914 regulation of T cell mediated cytotoxicity(GO:0001914)
0.0 0.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0000303 response to superoxide(GO:0000303)
0.0 0.1 GO:1901224 activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0 0.0 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:1901862 negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
0.0 0.2 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0048867 stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0 0.1 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.0 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.1 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.0 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.0 GO:0002836 regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0 0.0 GO:0002709 regulation of T cell mediated immunity(GO:0002709)
0.0 0.0 GO:0050665 hydrogen peroxide biosynthetic process(GO:0050665)
0.0 0.0 GO:0043501 skeletal muscle adaptation(GO:0043501)
0.0 0.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.0 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.0 GO:0055064 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0018208 peptidyl-proline modification(GO:0018208)
0.0 0.0 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.0 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.0 GO:0090382 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0 0.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:2001021 negative regulation of response to DNA damage stimulus(GO:2001021)
0.0 0.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.0 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.0 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.0 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.1 GO:0055075 potassium ion homeostasis(GO:0055075)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1 0.4 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.0 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.0 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0000299 obsolete integral to membrane of membrane fraction(GO:0000299)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.0 GO:0038201 TORC1 complex(GO:0031931) TOR complex(GO:0038201)
0.0 0.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0031105 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.0 GO:0032009 early phagosome(GO:0032009)
0.0 0.0 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.2 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.5 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)
0.1 0.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.2 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.3 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.1 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.5 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.3 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.2 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
0.0 0.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.0 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.0 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.0 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.0 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.0 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.0 GO:0008518 reduced folate carrier activity(GO:0008518)
0.0 0.0 GO:0005113 patched binding(GO:0005113)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.4 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.0 GO:0046978 TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0 0.0 GO:0001848 complement binding(GO:0001848)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.1 GO:0003709 obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.0 GO:0002060 purine nucleobase binding(GO:0002060)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.0 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.4 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.0 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.1 PID EPO PATHWAY EPO signaling pathway
0.0 0.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.1 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.1 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.0 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.0 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.0 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.0 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.0 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.6 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.0 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.0 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.1 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.0 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.1 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.1 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI