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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RXRA_NR2F6_NR2C2

Z-value: 1.10

Motif logo

Transcription factors associated with RXRA_NR2F6_NR2C2

Gene Symbol	Gene ID	Gene Info
RXRA Ensembl NCBI GeneCards UniProt	ENSG00000186350.8	RXRA
NR2F6 Ensembl NCBI GeneCards UniProt	ENSG00000160113.5	NR2F6
NR2C2 Ensembl NCBI GeneCards UniProt	ENSG00000177463.11	NR2C2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NR2C2	chr3_15030879_15031030	14468	0.201569	0.64	6.1e-02	Click!
NR2C2	chr3_15001001_15001179	2824	0.283320	-0.48	1.9e-01	Click!
NR2C2	chr3_15052457_15052608	7110	0.219334	-0.22	5.8e-01	Click!
NR2C2	chr3_15030493_15030644	14854	0.200687	0.17	6.5e-01	Click!
NR2C2	chr3_15028082_15028233	17265	0.195105	0.13	7.5e-01	Click!
NR2F6	chr19_17356354_17356505	320	0.738809	0.33	3.8e-01	Click!
NR2F6	chr19_17355272_17355498	72	0.926116	-0.32	4.0e-01	Click!
NR2F6	chr19_17355503_17355912	394	0.668365	-0.20	6.1e-01	Click!
NR2F6	chr19_17357023_17357252	388	0.672975	-0.10	8.1e-01	Click!
NR2F6	chr19_17355975_17356268	628	0.474279	-0.06	8.8e-01	Click!
RXRA	chr9_137296411_137296683	1881	0.410203	0.85	3.7e-03	Click!
RXRA	chr9_137326628_137326779	28275	0.207889	-0.82	6.6e-03	Click!
RXRA	chr9_137160017_137160168	58334	0.129573	0.78	1.3e-02	Click!
RXRA	chr9_137335451_137335655	37125	0.185535	0.74	2.1e-02	Click!
RXRA	chr9_137297323_137297474	1030	0.613547	0.72	3.0e-02	Click!

Activity of the RXRA_NR2F6_NR2C2 motif across conditions

Conditions sorted by the z-value of the RXRA_NR2F6_NR2C2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_10416066_10416280	0.96	ZGLP1	zinc finger, GATA-like protein 1	4286	0.08
chr17_79879240_79879391	0.65	SIRT7	sirtuin 7	116	0.85
chr6_14721018_14721200	0.62	ENSG00000206960	.	74343	0.13
chrX_65235295_65235677	0.61	ENSG00000207939	.	3226	0.26
chr12_54694994_54695195	0.60	COPZ1	coatomer protein complex, subunit zeta 1	108	0.6
chr12_1922066_1922217	0.58	CACNA2D4	calcium channel, voltage-dependent, alpha 2/delta subunit 4	1184	0.5
chr22_37260110_37260261	0.56	NCF4	neutrophil cytosolic factor 4, 40kDa	3155	0.18
chr14_73931523_73931791	0.54	ENSG00000251393	.	2528	0.22
chr10_129678816_129678967	0.50	CLRN3	clarin 3	12320	0.22
chr16_47050823_47051091	0.49	RP11-169E6.1		43057	0.14
chr9_70850762_70850954	0.45	CBWD3	COBW domain containing 3	5539	0.19
chr7_143078673_143079796	0.45	ZYX	zyxin	234	0.85
chr11_1781045_1781196	0.43	AC068580.6		458	0.52
chr6_109561771_109561922	0.42	ENSG00000238474	.	50715	0.12
chr19_18334931_18335362	0.42	PDE4C	phosphodiesterase 4C, cAMP-specific	157	0.91
chr6_13274566_13274804	0.42	RP1-257A7.4		394	0.82
chr17_81011742_81011893	0.41	B3GNTL1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	2131	0.35
chr2_60783649_60784435	0.41	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	3340	0.31
chr20_4807814_4807965	0.40	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	3598	0.24
chr4_6927779_6927930	0.39	TBC1D14	TBC1 domain family, member 14	15879	0.16
chr3_171684620_171684771	0.37	TMEM212-IT1	TMEM212 intronic transcript 1 (non-protein coding)	72469	0.1
chr11_72448382_72448649	0.37	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	10342	0.12
chr15_77711149_77711991	0.37	PEAK1	pseudopodium-enriched atypical kinase 1	872	0.51
chr9_35685699_35685887	0.36	TPM2	tropomyosin 2 (beta)	330	0.73
chr6_31927037_31927267	0.35	SKIV2L	superkiller viralicidic activity 2-like (S. cerevisiae)	204	0.52
chr9_69268507_69268733	0.35	CBWD6	COBW domain containing 6	6027	0.21
chr18_2049997_2050208	0.35	METTL4	methyltransferase like 4	504589	0.0
chr1_153362333_153362484	0.35	S100A8	S100 calcium binding protein A8	1044	0.37
chr14_20896169_20896332	0.34	KLHL33	kelch-like family member 33	7551	0.08
chr11_113954202_113954403	0.34	ENSG00000221112	.	3349	0.28
chr19_47234689_47234868	0.34	CTB-174O21.2		2918	0.12
chr5_36067012_36067195	0.34	UGT3A2	UDP glycosyltransferase 3 family, polypeptide A2	110	0.97
chr17_7123160_7124223	0.34	ACADVL	acyl-CoA dehydrogenase, very long chain	424	0.48
chr11_22688489_22688994	0.33	GAS2	growth arrest-specific 2	119	0.97
chr12_56537034_56537185	0.33	MYL6B	myosin, light chain 6B, alkali, smooth muscle and non-muscle	8931	0.06
chr2_219646650_219647418	0.33	CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	555	0.7
chr16_1990929_1991093	0.32	MSRB1	methionine sulfoxide reductase B1	2113	0.1
chr22_32033546_32033968	0.32	PISD	phosphatidylserine decarboxylase	634	0.74
chr20_4943157_4943308	0.32	SLC23A2	solute carrier family 23 (ascorbic acid transporter), member 2	38913	0.14
chr1_33463602_33463869	0.32	RP1-117O3.2		11059	0.14
chr2_113592071_113592291	0.31	IL1B	interleukin 1, beta	1830	0.31
chr2_234257769_234257933	0.31	RP11-400N9.1		4211	0.17
chr7_41731347_41731498	0.31	INHBA-AS1	INHBA antisense RNA 1	2092	0.34
chr8_38722630_38723350	0.30	RP11-723D22.3		19033	0.16
chr8_68880458_68880609	0.30	PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	16180	0.28
chr15_49087139_49087290	0.30	RP11-485O10.2		11827	0.17
chr1_226374129_226374763	0.30	ACBD3	acyl-CoA binding domain containing 3	15	0.98
chr20_62713551_62713939	0.30	C20orf201	chromosome 20 open reading frame 201	1967	0.15
chr1_12079558_12080233	0.30	MIIP	migration and invasion inhibitory protein	305	0.84
chr12_96514891_96515042	0.30	ENSG00000266889	.	18939	0.19
chr19_10362934_10363426	0.30	MRPL4	mitochondrial ribosomal protein L4	228	0.83
chr2_232545912_232546437	0.29	MGC4771		25447	0.14
chr1_2987231_2987751	0.29	PRDM16	PR domain containing 16	1716	0.34
chr19_6738037_6738395	0.29	TRIP10	thyroid hormone receptor interactor 10	280	0.7
chr10_73511646_73511797	0.28	C10orf54	chromosome 10 open reading frame 54	5666	0.21
chr1_235091297_235091455	0.28	ENSG00000239690	.	51443	0.16
chr21_39756340_39756646	0.28	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	87645	0.09
chr17_48367766_48367999	0.28	RP11-893F2.9		2666	0.19
chrX_117858717_117858999	0.28	IL13RA1	interleukin 13 receptor, alpha 1	2677	0.32
chr14_60620645_60620999	0.28	DHRS7	dehydrogenase/reductase (SDR family) member 7	930	0.61
chr15_53495921_53496072	0.27	ONECUT1	one cut homeobox 1	413787	0.01
chrX_2809831_2809982	0.27	ARSD-AS1	ARSD antisense RNA 1	13039	0.15
chr16_28506110_28506360	0.27	APOBR	apolipoprotein B receptor	242	0.75
chr11_72527375_72527681	0.27	ATG16L2	autophagy related 16-like 2 (S. cerevisiae)	2051	0.23
chr12_54688592_54688942	0.27	NFE2	nuclear factor, erythroid 2	775	0.4
chr22_51020587_51021277	0.27	CHKB	choline kinase beta	496	0.39
chr20_1876393_1876635	0.27	SIRPA	signal-regulatory protein alpha	572	0.81
chr20_48808829_48809749	0.26	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	1913	0.35
chr6_149450767_149450918	0.26	ENSG00000263481	.	47088	0.15
chr16_85325294_85325445	0.26	ENSG00000266307	.	14562	0.24
chr13_114271046_114271197	0.26	TFDP1	transcription factor Dp-1	31380	0.15
chr19_43849967_43850118	0.26	CD177	CD177 molecule	7783	0.17
chr8_33412041_33412395	0.26	RNF122	ring finger protein 122	12425	0.13
chr7_106065721_106066226	0.26	CTB-111H14.1		79312	0.1
chr11_6656944_6657095	0.26	RP11-732A19.6		5185	0.09
chr19_48866469_48867161	0.26	TMEM143	transmembrane protein 143	116	0.89
chr19_36399282_36399433	0.26	TYROBP	TYRO protein tyrosine kinase binding protein	160	0.9
chr12_109122720_109122871	0.26	CORO1C	coronin, actin binding protein, 1C	1532	0.34
chr15_70384544_70384773	0.26	TLE3	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	2466	0.34
chr3_64811829_64811980	0.25	ADAMTS9	ADAM metallopeptidase with thrombospondin type 1 motif, 9	138228	0.05
chr17_48205902_48206073	0.25	SAMD14	sterile alpha motif domain containing 14	1131	0.31
chr17_4615541_4615774	0.25	ARRB2	arrestin, beta 2	1663	0.18
chr2_113945024_113945175	0.25	PSD4	pleckstrin and Sec7 domain containing 4	8758	0.14
chr17_29701117_29701268	0.25	NF1	neurofibromin 1	15626	0.14
chr15_99417963_99418437	0.25	IGF1R	insulin-like growth factor 1 receptor	15370	0.2
chr2_7075634_7075785	0.25	RNF144A	ring finger protein 144A	2535	0.29
chr1_160832331_160832502	0.25	CD244	CD244 molecule, natural killer cell receptor 2B4	74	0.97
chr19_43891664_43891815	0.25	TEX101	testis expressed 101	13909	0.15
chr18_2984866_2985017	0.24	LPIN2	lipin 2	2070	0.27
chr10_73456429_73456580	0.24	C10orf105	chromosome 10 open reading frame 105	23074	0.2
chr10_14730758_14730909	0.24	ENSG00000201766	.	25340	0.19
chr6_56668655_56668840	0.24	DST	dystonin	18070	0.23
chr7_95238082_95238332	0.24	AC002451.3		901	0.62
chr1_236056109_236056279	0.24	LYST	lysosomal trafficking regulator	9322	0.17
chr7_139530944_139531095	0.24	TBXAS1	thromboxane A synthase 1 (platelet)	1909	0.44
chr12_129338589_129338740	0.24	GLT1D1	glycosyltransferase 1 domain containing 1	583	0.82
chr20_32399297_32399983	0.24	CHMP4B	charged multivesicular body protein 4B	530	0.55
chr12_111843881_111845308	0.23	SH2B3	SH2B adaptor protein 3	842	0.62
chr20_17660855_17661298	0.23	RRBP1	ribosome binding protein 1	1629	0.4
chr11_67043892_67044043	0.23	ADRBK1	adrenergic, beta, receptor kinase 1	10015	0.11
chr5_77306460_77306689	0.23	AP3B1	adaptor-related protein complex 3, beta 1 subunit	28400	0.21
chr1_147119514_147119665	0.23	ACP6	acid phosphatase 6, lysophosphatidic	11527	0.22
chr5_149465296_149465474	0.23	CSF1R	colony stimulating factor 1 receptor	605	0.69
chr10_30831582_30831733	0.23	ENSG00000239744	.	13176	0.24
chrX_19904584_19904836	0.23	SH3KBP1	SH3-domain kinase binding protein 1	867	0.7
chr16_66638822_66640143	0.23	CMTM3	CKLF-like MARVEL transmembrane domain containing 3	58	0.95
chrX_153659493_153659733	0.22	ATP6AP1	ATPase, H+ transporting, lysosomal accessory protein 1	2604	0.11
chr19_1154555_1155129	0.22	SBNO2	strawberry notch homolog 2 (Drosophila)	293	0.85
chr7_105317322_105317473	0.22	ATXN7L1	ataxin 7-like 1	2212	0.41
chr7_99954721_99954872	0.22	PILRB	paired immunoglobin-like type 2 receptor beta	207	0.86
chr21_44158180_44158391	0.22	AP001627.1		3583	0.28
chr8_142105945_142106235	0.22	DENND3	DENN/MADD domain containing 3	21287	0.19
chr15_74232964_74233156	0.22	LOXL1-AS1	LOXL1 antisense RNA 1	12471	0.14
chr11_47416116_47416267	0.22	RP11-750H9.5		1000	0.33
chr11_75474128_75474279	0.22	DGAT2	diacylglycerol O-acyltransferase 2	3646	0.13
chr19_1068246_1068401	0.22	HMHA1	histocompatibility (minor) HA-1	826	0.4
chr6_76317008_76317159	0.22	SENP6	SUMO1/sentrin specific peptidase 6	5320	0.19
chr19_676350_676550	0.21	FSTL3	follistatin-like 3 (secreted glycoprotein)	58	0.95
chr20_31061401_31061552	0.21	C20orf112	chromosome 20 open reading frame 112	9798	0.18
chr7_40591526_40591750	0.21	AC004988.1		5111	0.35
chr9_35730052_35730203	0.21	CREB3	cAMP responsive element binding protein 3	2205	0.12
chr12_562387_562595	0.21	B4GALNT3	beta-1,4-N-acetyl-galactosaminyl transferase 3	7039	0.21
chr1_23850782_23850933	0.21	E2F2	E2F transcription factor 2	6855	0.18
chr18_9827953_9828104	0.21	ENSG00000242651	.	2596	0.28
chr9_110253387_110253828	0.21	KLF4	Kruppel-like factor 4 (gut)	844	0.66
chr11_121325996_121326147	0.21	RP11-730K11.1		2349	0.33
chr6_110118234_110118385	0.21	FIG4	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	11100	0.28
chr9_184980_185177	0.21	CBWD1	COBW domain containing 1	6006	0.2
chr20_36824815_36825080	0.20	TGM2	transglutaminase 2	29967	0.14
chr10_98418237_98418708	0.20	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	10896	0.21
chr22_31625332_31625483	0.20	ENSG00000202019	.	751	0.5
chr10_29977190_29977386	0.20	ENSG00000222092	.	23556	0.21
chr9_123500093_123500244	0.20	MEGF9	multiple EGF-like-domains 9	23420	0.2
chr17_25859259_25859414	0.20	KSR1	kinase suppressor of ras 1	50611	0.13
chr6_131895362_131895513	0.20	ARG1	arginase 1	1072	0.55
chr16_57126935_57127447	0.20	CPNE2	copine II	672	0.49
chr15_58438968_58439119	0.20	ALDH1A2	aldehyde dehydrogenase 1 family, member A2	8019	0.23
chr2_85727105_85727457	0.20	ENSG00000266577	.	32468	0.08
chr19_6067059_6067210	0.20	CTC-232P5.3		830	0.55
chr11_47416652_47416817	0.20	RP11-750H9.5		457	0.65
chr1_12046473_12046624	0.20	MFN2	mitofusin 2	4499	0.15
chr22_36795299_36795450	0.20	MYH9	myosin, heavy chain 9, non-muscle	11311	0.17
chr16_20756487_20756638	0.20	THUMPD1	THUMP domain containing 1	3156	0.18
chr17_36584744_36585461	0.20	ARHGAP23	Rho GTPase activating protein 23	372	0.84
chr3_53201341_53201492	0.19	PRKCD	protein kinase C, delta	2271	0.28
chr16_90033999_90034150	0.19	RP11-566K11.5		2125	0.18
chr2_102609682_102609833	0.19	IL1R2	interleukin 1 receptor, type II	1451	0.51
chr7_76033306_76033511	0.19	SRCRB4D	scavenger receptor cysteine rich domain containing, group B (4 domains)	5604	0.17
chr6_33172447_33173020	0.19	HSD17B8	hydroxysteroid (17-beta) dehydrogenase 8	314	0.73
chr6_49603951_49604102	0.19	RHAG	Rh-associated glycoprotein	526	0.83
chr2_27602964_27603512	0.19	ZNF513	zinc finger protein 513	73	0.93
chr1_169861896_169862644	0.19	SCYL3	SCY1-like 3 (S. cerevisiae)	806	0.65
chr13_108974971_108975122	0.19	ENSG00000223177	.	21367	0.23
chr12_89551363_89551514	0.19	ENSG00000238302	.	124624	0.06
chr17_73305250_73305401	0.19	GRB2	growth factor receptor-bound protein 2	12509	0.09
chr1_174938035_174938186	0.19	RABGAP1L	RAB GTPase activating protein 1-like	4205	0.17
chr5_101631358_101631636	0.19	SLCO4C1	solute carrier organic anion transporter family, member 4C1	756	0.68
chr2_70172880_70173031	0.19	ENSG00000239072	.	9822	0.12
chr2_113190375_113190911	0.19	RGPD8	RANBP2-like and GRIP domain containing 8	453	0.86
chr19_12899418_12899647	0.19	ENSG00000263800	.	1590	0.15
chr19_42133062_42133277	0.19	CEACAM4	carcinoembryonic antigen-related cell adhesion molecule 4	273	0.89
chr12_105122483_105122634	0.19	ENSG00000222579	.	123044	0.05
chr9_117895091_117895381	0.18	DEC1	deleted in esophageal cancer 1	8861	0.25
chr4_353397_353548	0.18	ENSG00000207642	.	9526	0.17
chr2_61153613_61153764	0.18	ENSG00000201076	.	15250	0.18
chr1_156474559_156474783	0.18	MEF2D	myocyte enhancer factor 2D	4051	0.14
chr7_642417_642568	0.18	PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta	172	0.69
chr17_77005019_77005688	0.18	CANT1	calcium activated nucleotidase 1	459	0.76
chr16_89042423_89042673	0.18	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	853	0.55
chr11_85781008_85781159	0.18	PICALM	phosphatidylinositol binding clathrin assembly protein	159	0.96
chr3_37284874_37285642	0.18	RP11-259K5.2		410	0.48
chr22_37257050_37257437	0.18	NCF4	neutrophil cytosolic factor 4, 40kDa	213	0.91
chr2_136690107_136690258	0.18	DARS	aspartyl-tRNA synthetase	12059	0.21
chr1_33812503_33812654	0.18	PHC2	polyhomeotic homolog 2 (Drosophila)	2908	0.16
chr1_154989875_154990097	0.18	ZBTB7B	zinc finger and BTB domain containing 7B	3062	0.1
chr9_34179429_34180002	0.18	UBAP1	ubiquitin associated protein 1	679	0.62
chr1_10475436_10475736	0.18	APITD1	apoptosis-inducing, TAF9-like domain 1	14573	0.1
chr1_155202832_155202983	0.18	ENSG00000216109	.	3721	0.07
chr15_57071498_57071649	0.18	ZNF280D	zinc finger protein 280D	45289	0.19
chr10_21814018_21814991	0.18	SKIDA1	SKI/DACH domain containing 1	107	0.95
chr1_99729766_99730318	0.18	LPPR4	Lipid phosphate phosphatase-related protein type 4	194	0.97
chrX_118894160_118894311	0.18	SOWAHD	sosondowah ankyrin repeat domain family member D	1659	0.32
chr1_38467251_38467531	0.18	FHL3	four and a half LIM domains 3	3786	0.15
chr15_40625954_40626153	0.18	ENSG00000252714	.	2204	0.13
chr2_45170446_45170597	0.18	SIX3-AS1	SIX3 antisense RNA 1	1509	0.36
chrX_138285953_138286466	0.17	FGF13	fibroblast growth factor 13	60	0.99
chr2_231735442_231735593	0.17	ITM2C	integral membrane protein 2C	5138	0.19
chr9_139928371_139928559	0.17	FUT7	fucosyltransferase 7 (alpha (1,3) fucosyltransferase)	1003	0.23
chr9_134460250_134460544	0.17	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	36828	0.13
chr2_11828981_11829132	0.17	AC106875.1		7469	0.13
chr5_124083658_124084316	0.17	ZNF608	zinc finger protein 608	513	0.71
chr9_35489468_35490886	0.17	RUSC2	RUN and SH3 domain containing 2	53	0.97
chr1_92941939_92942090	0.17	GFI1	growth factor independent 1 transcription repressor	7497	0.27
chr20_30125745_30125896	0.17	HM13	histocompatibility (minor) 13	23496	0.1
chr19_16482178_16482409	0.17	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	9529	0.15
chr17_75382520_75382671	0.17	SEPT9	septin 9	6390	0.17
chr19_1019836_1021109	0.17	TMEM259	transmembrane protein 259	373	0.62
chr3_10231486_10231637	0.17	IRAK2	interleukin-1 receptor-associated kinase 2	25012	0.1
chrX_118894330_118894481	0.17	SOWAHD	sosondowah ankyrin repeat domain family member D	1829	0.3
chr17_1090163_1090534	0.17	ABR	active BCR-related	268	0.91

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RXRA_NR2F6_NR2C2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0045897	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.1	0.2	GO:0010193	response to ozone(GO:0010193)
0.1	0.4	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.2	GO:0071318	cellular response to ATP(GO:0071318)
0.1	0.4	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.1	0.2	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.1	0.4	GO:0031498	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1	0.2	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.2	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.4	GO:0048205	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.2	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.2	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.2	GO:0015851	nucleobase transport(GO:0015851)
0.0	0.1	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.0	GO:0052564	response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:0045007	depurination(GO:0045007)
0.0	0.2	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.1	GO:0003079	obsolete positive regulation of natriuresis(GO:0003079)
0.0	0.2	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0090206	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.2	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0050665	hydrogen peroxide biosynthetic process(GO:0050665)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.0	0.1	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.1	GO:0015809	arginine transport(GO:0015809)
0.0	0.2	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.0	GO:0051136	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.1	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.2	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.0	0.1	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.1	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.2	GO:0045060	negative thymic T cell selection(GO:0045060)
0.0	0.0	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0	0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0048703	embryonic viscerocranium morphogenesis(GO:0048703)
0.0	0.1	GO:0006657	CDP-choline pathway(GO:0006657)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0030851	granulocyte differentiation(GO:0030851)
0.0	0.1	GO:1901532	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.1	GO:0032292	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.0	GO:0008615	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.0	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.3	GO:0043462	regulation of ATPase activity(GO:0043462)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.0	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0031054	pre-miRNA processing(GO:0031054)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.2	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.0	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.2	GO:0051923	sulfation(GO:0051923)
0.0	0.1	GO:0046719	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.0	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.1	GO:0007549	dosage compensation(GO:0007549)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.0	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0045217	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.2	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.0	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.2	GO:0016180	snRNA processing(GO:0016180)
0.0	0.0	GO:0051290	protein heterotetramerization(GO:0051290)
0.0	0.0	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0048865	stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0	0.2	GO:0033003	regulation of mast cell activation(GO:0033003)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.0	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.0	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.0	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.2	GO:0006027	glycosaminoglycan catabolic process(GO:0006027)
0.0	0.0	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.4	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.0	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.0	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.0	GO:0033605	positive regulation of catecholamine secretion(GO:0033605)
0.0	0.2	GO:0016925	protein sumoylation(GO:0016925)
0.0	0.1	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.0	GO:0043137	DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0	0.1	GO:0000002	mitochondrial genome maintenance(GO:0000002)
0.0	0.0	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.0	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0	0.0	GO:0003160	endocardium development(GO:0003157) endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214)
0.0	0.0	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.1	GO:0015884	folic acid transport(GO:0015884)
0.0	0.1	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0	0.1	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.1	GO:0006895	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.4	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.4	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.6	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.5	GO:0044452	nucleolar part(GO:0044452)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0071817	MMXD complex(GO:0071817)
0.0	0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.0	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.4	GO:0005884	actin filament(GO:0005884)
0.0	0.2	GO:0032039	integrator complex(GO:0032039)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.0	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0038201	TOR complex(GO:0038201)
0.0	0.0	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0	0.0	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.0	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.2	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	0.0	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1	0.2	GO:0042577	lipid phosphatase activity(GO:0042577)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.2	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0	0.6	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.2	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.2	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345)
0.0	0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.0	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.2	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0015205	nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.2	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.2	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.5	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.2	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.3	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.2	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.2	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0015368	calcium:cation antiporter activity(GO:0015368)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.5	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.2	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.0	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.3	GO:0050699	WW domain binding(GO:0050699)
0.0	0.0	GO:0043495	protein anchor(GO:0043495)
0.0	0.0	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0032129	NAD-dependent histone deacetylase activity(GO:0017136) histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H3-K9 specific)(GO:0032129) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent protein deacetylase activity(GO:0034979) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.2	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.0	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.0	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.0	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.2	GO:0030552	cAMP binding(GO:0030552)
0.0	0.0	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.0	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.0	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.0	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.2	GO:0070001	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0005451	monovalent cation:proton antiporter activity(GO:0005451)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.0	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.0	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0000062	fatty-acyl-CoA binding(GO:0000062)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.5	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.7	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.4	PID IL3 PATHWAY	IL3-mediated signaling events
0.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.6	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.4	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.3	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.4	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.4	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.5	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.2	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.2	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.3	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.1	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules