Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RXRG

Z-value: 0.95

Motif logo

Transcription factors associated with RXRG

Gene Symbol	Gene ID	Gene Info
RXRG Ensembl NCBI GeneCards UniProt	ENSG00000143171.8	RXRG

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
RXRG	chr1_165394173_165394324	20185	0.213009	0.54	1.4e-01	Click!
RXRG	chr1_165393775_165394037	20527	0.212169	0.43	2.5e-01	Click!
RXRG	chr1_165393515_165393674	20839	0.211397	0.29	4.5e-01	Click!
RXRG	chr1_165414435_165414651	110	0.975187	0.28	4.6e-01	Click!
RXRG	chr1_165414145_165414329	196	0.957396	0.13	7.3e-01	Click!

Activity of the RXRG motif across conditions

Conditions sorted by the z-value of the RXRG motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_3749707_3750198	0.32	RP11-420L9.5		1393	0.41
chr2_243030793_243031816	0.28	AC093642.5		460	0.62
chr3_50193036_50193699	0.28	RP11-493K19.3		86	0.87
chr3_184280128_184280591	0.27	EPHB3	EPH receptor B3	787	0.64
chr20_3661411_3661562	0.26	ADAM33	ADAM metallopeptidase domain 33	1264	0.38
chr2_27301899_27302732	0.25	EMILIN1	elastin microfibril interfacer 1	880	0.32
chr7_100200266_100200615	0.25	PCOLCE-AS1	PCOLCE antisense RNA 1	218	0.74
chr3_190580567_190581193	0.24	GMNC	geminin coiled-coil domain containing	476	0.9
chr19_2720626_2720882	0.24	DIRAS1	DIRAS family, GTP-binding RAS-like 1	585	0.6
chr13_97899006_97899219	0.24	MBNL2	muscleblind-like splicing regulator 2	24503	0.25
chr14_103674063_103674327	0.24	ENSG00000239117	.	4672	0.24
chr19_50031610_50031873	0.23	RCN3	reticulocalbin 3, EF-hand calcium binding domain	142	0.87
chr3_44038033_44038921	0.23	ENSG00000252980	.	74102	0.11
chr22_51136634_51136785	0.22	ENSG00000206841	.	6918	0.12
chr2_239754137_239754288	0.22	TWIST2	twist family bHLH transcription factor 2	2461	0.38
chr8_145925356_145925968	0.22	AF186192.5		5257	0.15
chr17_59474132_59474398	0.22	RP11-332H18.4		1457	0.28
chr1_33207592_33208218	0.22	KIAA1522	KIAA1522	419	0.8
chr13_74315255_74315493	0.22	KLF12	Kruppel-like factor 12	253812	0.02
chr10_11784750_11785238	0.22	ECHDC3	enoyl CoA hydratase domain containing 3	549	0.83
chr4_20255917_20256182	0.21	SLIT2	slit homolog 2 (Drosophila)	494	0.89
chr17_29887977_29888214	0.21	ENSG00000207614	.	1080	0.35
chr4_87517608_87517759	0.21	PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	837	0.62
chr12_77719208_77719557	0.21	ENSG00000238769	.	162577	0.04
chr11_35440407_35440646	0.21	RP4-683L5.1		78	0.51
chr1_1292304_1292633	0.21	MXRA8	matrix-remodelling associated 8	1447	0.18
chr7_47576453_47576928	0.20	TNS3	tensin 3	2185	0.45
chr21_46825103_46825740	0.20	COL18A1	collagen, type XVIII, alpha 1	369	0.83
chr22_43116992_43117164	0.20	A4GALT	alpha 1,4-galactosyltransferase	25439	0.15
chr1_6336062_6336213	0.20	GPR153	G protein-coupled receptor 153	15102	0.12
chr8_37350646_37351319	0.20	RP11-150O12.6		23557	0.24
chr16_30996731_30996937	0.20	HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	297	0.67
chr8_48100683_48101124	0.19	IGLV8OR8-1	immunoglobulin lambda variable 8/OR8-1 (pseudogene)	13617	0.23
chr19_49631799_49632178	0.19	PPFIA3	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	857	0.37
chr22_46482810_46483184	0.19	FLJ27365	hsa-mir-4763	1114	0.31
chr7_143208334_143208676	0.19	TAS2R41	taste receptor, type 2, member 41	33539	0.13
chr8_6407769_6407977	0.19	ANGPT2	angiopoietin 2	12692	0.26
chr3_44041432_44041583	0.18	ENSG00000252980	.	71072	0.12
chr19_35522133_35522284	0.18	SCN1B	sodium channel, voltage-gated, type I, beta subunit	483	0.65
chr2_110538980_110539399	0.18	RGPD5	RANBP2-like and GRIP domain containing 5	11146	0.28
chr2_158113918_158114875	0.18	GALNT5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	286	0.93
chr19_11305569_11305933	0.18	KANK2	KN motif and ankyrin repeat domains 2	117	0.94
chr1_14924992_14926197	0.17	KAZN	kazrin, periplakin interacting protein	381	0.93
chr14_71605949_71606105	0.17	PCNX	pecanex homolog (Drosophila)	30290	0.22
chr15_42749089_42749416	0.17	ZNF106	zinc finger protein 106	459	0.78
chr10_79397825_79398297	0.17	KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	66	0.98
chr1_19972193_19972357	0.17	NBL1	neuroblastoma 1, DAN family BMP antagonist	15	0.97
chr11_114166754_114166905	0.17	NNMT	nicotinamide N-methyltransferase	282	0.93
chr7_5594937_5595088	0.17	CTB-161C1.1		1350	0.33
chr3_120170199_120170358	0.17	FSTL1	follistatin-like 1	178	0.97
chr17_15164779_15165041	0.17	RP11-849N15.1		578	0.55
chr22_43115644_43116713	0.17	A4GALT	alpha 1,4-galactosyltransferase	24539	0.15
chr14_38064473_38064843	0.17	TTC6	tetratricopeptide repeat domain 6	394	0.5
chr11_64427770_64427921	0.17	AP001092.4		13974	0.14
chr6_6928235_6928478	0.17	ENSG00000240936	.	10774	0.29
chr7_27212262_27212557	0.17	HOXA10	homeobox A10	1516	0.14
chr15_96888963_96889465	0.17	ENSG00000222651	.	12724	0.15
chr4_187760936_187761144	0.17	ENSG00000252382	.	17570	0.28
chr11_1890233_1890398	0.17	LSP1	lymphocyte-specific protein 1	59	0.95
chr7_28725956_28726399	0.17	CREB5	cAMP responsive element binding protein 5	579	0.86
chr19_11466484_11467017	0.17	DKFZP761J1410	Lipid phosphate phosphatase-related protein type 2	576	0.52
chr19_1154555_1155129	0.17	SBNO2	strawberry notch homolog 2 (Drosophila)	293	0.85
chr3_104010225_104010492	0.17	ENSG00000265076	.	236718	0.02
chr18_10798656_10798816	0.16	PIEZO2	piezo-type mechanosensitive ion channel component 2	7088	0.29
chr2_200320961_200321297	0.16	SATB2	SATB homeobox 2	318	0.86
chr19_49370765_49371212	0.16	PLEKHA4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	136	0.91
chr5_80529205_80529404	0.16	CKMT2	creatine kinase, mitochondrial 2 (sarcomeric)	160	0.97
chr9_110349763_110350130	0.16	ENSG00000202308	.	75581	0.1
chr16_3162631_3163041	0.16	ZNF205	zinc finger protein 205	40	0.8
chr1_7844777_7844986	0.16	PER3	period circadian clock 3	118	0.95
chr10_119312845_119313011	0.16	EMX2OS	EMX2 opposite strand/antisense RNA	8349	0.24
chr16_4313997_4314233	0.16	TFAP4	transcription factor AP-4 (activating enhancer binding protein 4)	377	0.84
chr18_72872404_72872616	0.16	ZADH2	zinc binding alcohol dehydrogenase domain containing 2	44958	0.18
chr19_6740138_6741070	0.16	TRIP10	thyroid hormone receptor interactor 10	325	0.81
chr16_863784_863935	0.16	PRR25	proline rich 25	8416	0.08
chr3_49170609_49171370	0.16	LAMB2	laminin, beta 2 (laminin S)	438	0.69
chr1_215256963_215257162	0.16	KCNK2	potassium channel, subfamily K, member 2	202	0.97
chr12_41086868_41087222	0.16	CNTN1	contactin 1	691	0.81
chr2_239768983_239769134	0.16	TWIST2	twist family bHLH transcription factor 2	12385	0.25
chr3_178336239_178336417	0.16	KCNMB2	potassium large conductance calcium-activated channel, subfamily M, beta member 2	59710	0.15
chr12_54377889_54378303	0.16	HOXC-AS3	HOXC cluster antisense RNA 3	12	0.88
chr4_8594931_8595082	0.16	CPZ	carboxypeptidase Z	523	0.82
chr1_32045069_32045220	0.16	TINAGL1	tubulointerstitial nephritis antigen-like 1	3005	0.19
chr7_96653221_96653741	0.15	DLX5	distal-less homeobox 5	781	0.6
chr19_49219826_49219992	0.15	MAMSTR	MEF2 activating motif and SAP domain containing transcriptional regulator	191	0.87
chr15_63336117_63336463	0.15	TPM1	tropomyosin 1 (alpha)	315	0.89
chr5_343772_343923	0.15	AHRR	aryl-hydrocarbon receptor repressor	204	0.94
chr16_54970178_54971110	0.15	IRX5	iroquois homeobox 5	4660	0.36
chr18_57127119_57127270	0.15	RP11-27G24.3		890	0.64
chr19_55684291_55685412	0.15	SYT5	synaptotagmin V	1083	0.28
chr8_93065009_93065160	0.15	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	10107	0.3
chr21_47407286_47407576	0.15	COL6A1	collagen, type VI, alpha 1	5780	0.22
chr19_35630347_35630545	0.15	FXYD1	FXYD domain containing ion transport regulator 1	101	0.93
chr19_41224717_41225149	0.15	ADCK4	aarF domain containing kinase 4	821	0.42
chr1_236227370_236227967	0.15	NID1	nidogen 1	741	0.67
chr22_51171783_51171934	0.15	AC000036.4		4709	0.13
chr15_33010201_33010591	0.15	GREM1	gremlin 1, DAN family BMP antagonist	191	0.95
chr5_67830491_67830731	0.15	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	242215	0.02
chr2_239760169_239760320	0.14	TWIST2	twist family bHLH transcription factor 2	3571	0.32
chr22_38657243_38657394	0.14	TMEM184B	transmembrane protein 184B	11352	0.11
chr20_34025363_34025770	0.14	GDF5	growth differentiation factor 5	457	0.71
chr2_119587998_119588149	0.14	EN1	engrailed homeobox 1	17181	0.27
chr6_166419178_166419506	0.14	ENSG00000252196	.	63513	0.12
chr5_170877536_170878064	0.14	FGF18	fibroblast growth factor 18	31140	0.17
chr3_106917697_106917905	0.14	ENSG00000220989	.	166228	0.04
chr22_22109080_22109472	0.14	YPEL1	yippee-like 1 (Drosophila)	19153	0.12
chr1_84227664_84227815	0.14	ENSG00000223231	.	31821	0.25
chr6_15897253_15897404	0.14	MYLIP	myosin regulatory light chain interacting protein	232028	0.02
chr6_23003728_23003960	0.14	ENSG00000207394	.	121471	0.07
chr15_76002333_76002682	0.14	CSPG4	chondroitin sulfate proteoglycan 4	2682	0.14
chr11_70245277_70245996	0.14	CTTN	cortactin	989	0.33
chr10_79398316_79398509	0.14	KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	59	0.98
chr6_114181963_114182196	0.14	MARCKS	myristoylated alanine-rich protein kinase C substrate	3538	0.24
chr15_43809873_43810151	0.14	MAP1A	microtubule-associated protein 1A	189	0.93
chr15_90371711_90371913	0.14	ANPEP	alanyl (membrane) aminopeptidase	13179	0.12
chr7_100765722_100766153	0.14	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	4433	0.12
chrY_1463557_1463741	0.14	NA	NA	> 10⁶	NA
chr19_1155345_1155615	0.14	SBNO2	strawberry notch homolog 2 (Drosophila)	345	0.81
chr17_75474006_75474173	0.14	SEPT9	septin 9	2764	0.22
chr19_18760778_18760992	0.14	KLHL26	kelch-like family member 26	13018	0.11
chr2_46557288_46557606	0.14	EPAS1	endothelial PAS domain protein 1	32906	0.2
chr1_214723618_214723885	0.14	PTPN14	protein tyrosine phosphatase, non-receptor type 14	815	0.74
chr4_95649180_95649331	0.14	BMPR1B	bone morphogenetic protein receptor, type IB	29864	0.26
chr1_162336853_162337007	0.14	C1orf226	chromosome 1 open reading frame 226	232	0.86
chr10_128594353_128594780	0.14	DOCK1	dedicator of cytokinesis 1	588	0.8
chr12_679488_679709	0.14	RP5-1154L15.2		16054	0.13
chr8_125827951_125828102	0.14	ENSG00000263735	.	6274	0.28
chr17_19066222_19066403	0.13	AC007952.6	Uncharacterized protein	3888	0.1
chr7_127761966_127762314	0.13	ENSG00000207588	.	40227	0.16
chr20_36531075_36531364	0.13	VSTM2L	V-set and transmembrane domain containing 2 like	280	0.93
chr16_58534138_58534342	0.13	NDRG4	NDRG family member 4	190	0.92
chr19_14606640_14606859	0.13	GIPC1	GIPC PDZ domain containing family, member 1	195	0.89
chr19_9473504_9474272	0.13	ZNF177	zinc finger protein 177	181	0.93
chr19_41073613_41074217	0.13	SHKBP1	SH3KBP1 binding protein 1	8842	0.14
chr1_212643718_212643913	0.13	NENF	neudesin neurotrophic factor	37586	0.14
chr17_881930_882232	0.13	NXN	nucleoredoxin	929	0.47
chr6_29974031_29974191	0.13	HLA-J	major histocompatibility complex, class I, J (pseudogene)	272	0.88
chr18_65691781_65691932	0.13	DSEL	dermatan sulfate epimerase-like	507639	0.0
chr5_126625896_126626411	0.13	MEGF10	multiple EGF-like-domains 10	370	0.91
chr20_60981442_60981982	0.13	CABLES2	Cdk5 and Abl enzyme substrate 2	629	0.63
chr2_229046102_229046253	0.13	SPHKAP	SPHK1 interactor, AKAP domain containing	165	0.97
chr11_66081550_66081990	0.13	RP11-867G23.13		1446	0.16
chr17_19118492_19118663	0.13	EPN2	epsin 2	351	0.77
chr5_77945062_77945285	0.13	LHFPL2	lipoma HMGIC fusion partner-like 2	525	0.88
chrX_1513557_1513776	0.13	SLC25A6	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	2049	0.26
chr1_227015624_227015805	0.13	PSEN2	presenilin 2 (Alzheimer disease 4)	42171	0.16
chr7_155006231_155006400	0.13	AC099552.4	Uncharacterized protein	16169	0.2
chr12_56115218_56115698	0.13	RDH5	retinol dehydrogenase 5 (11-cis/9-cis)	1261	0.23
chr20_52533519_52533820	0.13	AC005220.3		23030	0.24
chr8_143782547_143782698	0.13	LY6K	lymphocyte antigen 6 complex, locus K	732	0.49
chr5_42423499_42423764	0.13	GHR	growth hormone receptor	248	0.96
chr4_189333265_189333416	0.13	RP11-366H4.3		268807	0.02
chr1_223302857_223303051	0.13	TLR5	toll-like receptor 5	5144	0.33
chr14_100346663_100346814	0.13	EML1	echinoderm microtubule associated protein like 1	14792	0.22
chr7_29603979_29604650	0.13	PRR15	proline rich 15	752	0.51
chr7_72980210_72980413	0.13	BCL7B	B-cell CLL/lymphoma 7B	7979	0.14
chr6_108490135_108490714	0.13	NR2E1	nuclear receptor subfamily 2, group E, member 1	457	0.8
chr19_2579056_2579259	0.13	CTC-265F19.2		32703	0.12
chr8_57358725_57358876	0.13	PENK	proenkephalin	211	0.73
chr11_60928884_60929113	0.13	VPS37C	vacuolar protein sorting 37 homolog C (S. cerevisiae)	91	0.97
chr22_28416332_28416483	0.13	ENSG00000235954	.	22842	0.17
chr17_1179389_1179559	0.13	TUSC5	tumor suppressor candidate 5	3483	0.21
chr7_100816521_100816891	0.13	NAT16	N-acetyltransferase 16 (GCN5-related, putative)	5811	0.1
chr10_100026603_100026754	0.13	LOXL4	lysyl oxidase-like 4	1329	0.48
chr2_151342879_151343387	0.13	RND3	Rho family GTPase 3	1048	0.71
chr12_127865548_127865745	0.13	ENSG00000253089	.	59746	0.16
chr8_130472273_130472436	0.13	ENSG00000263763	.	24034	0.12
chr12_52404603_52404754	0.12	GRASP	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	289	0.86
chr4_188097696_188097847	0.12	ENSG00000252382	.	319161	0.01
chr11_66080835_66080986	0.12	RP11-867G23.13		586	0.45
chr17_13503597_13503828	0.12	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	1532	0.51
chr11_9113358_9113598	0.12	SCUBE2	signal peptide, CUB domain, EGF-like 2	328	0.83
chr9_112259733_112260156	0.12	PTPN3	protein tyrosine phosphatase, non-receptor type 3	642	0.76
chrX_11445632_11445915	0.12	ARHGAP6	Rho GTPase activating protein 6	120	0.98
chr16_86866838_86867009	0.12	FOXL1	forkhead box L1	254808	0.02
chr11_111784054_111784237	0.12	CRYAB	crystallin, alpha B	74	0.89
chr11_65292927_65293752	0.12	SCYL1	SCY1-like 1 (S. cerevisiae)	455	0.69
chr19_46985200_46985424	0.12	PNMAL1	paraneoplastic Ma antigen family-like 1	10492	0.13
chr2_236569141_236569292	0.12	AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	9032	0.28
chr12_1905695_1906675	0.12	CACNA2D4	calcium channel, voltage-dependent, alpha 2/delta subunit 4	14701	0.2
chr22_16193199_16193350	0.12	LL22NC03-N64E9.1		12270	0.18
chr20_30063006_30063157	0.12	REM1	RAS (RAD and GEM)-like GTP-binding 1	15	0.96
chr8_23201528_23201679	0.12	ENSG00000253837	.	7882	0.17
chr16_69207418_69207583	0.12	ENSG00000207083	.	2180	0.21
chr7_19155713_19156221	0.12	TWIST1	twist family bHLH transcription factor 1	1328	0.36
chr20_31045078_31045234	0.12	RP5-1184F4.5		7598	0.18
chr10_49812202_49812558	0.12	ARHGAP22	Rho GTPase activating protein 22	617	0.77
chr12_57620921_57621410	0.12	ENSG00000202067	.	592	0.53
chr7_96634475_96634654	0.12	DLX6	distal-less homeobox 6	296	0.79
chr3_131854540_131854927	0.12	CPNE4	copine IV	96283	0.08
chr2_218866425_218866801	0.12	TNS1	tensin 1	1105	0.51
chr11_67210244_67210509	0.12	CORO1B	coronin, actin binding protein, 1B	567	0.48
chr11_64067205_64067580	0.12	TEX40	testis expressed 40	471	0.54
chr9_35110303_35110495	0.12	FAM214B	family with sequence similarity 214, member B	1021	0.37
chr14_33092835_33092986	0.12	AKAP6	A kinase (PRKA) anchor protein 6	112147	0.07
chr9_133482900_133483051	0.12	FUBP3	far upstream element (FUSE) binding protein 3	27982	0.18
chr6_161664635_161664811	0.12	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4	30328	0.25
chr17_17110093_17110388	0.12	PLD6	phospholipase D family, member 6	611	0.61
chr19_11275038_11275287	0.12	SPC24	SPC24, NDC80 kinetochore complex component	8678	0.12
chr5_112823740_112823994	0.12	MCC	mutated in colorectal cancers	660	0.69

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RXRG

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.1	0.4	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.1	0.3	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.2	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.1	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.3	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.1	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.2	GO:0060976	coronary vasculature development(GO:0060976)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0000255	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.1	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.2	GO:0071549	cellular response to dexamethasone stimulus(GO:0071549)
0.0	0.1	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.2	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.1	GO:0001553	luteinization(GO:0001553)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.1	GO:0061004	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0	0.1	GO:1903579	negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.0	0.2	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.1	GO:0035610	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.0	GO:0060510	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.0	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0014824	tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0	0.1	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.3	GO:0061036	positive regulation of cartilage development(GO:0061036)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0046022	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.2	GO:0002076	osteoblast development(GO:0002076)
0.0	0.1	GO:0045830	positive regulation of isotype switching(GO:0045830)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.0	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.0	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.3	GO:0045668	negative regulation of osteoblast differentiation(GO:0045668)
0.0	0.1	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.0	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.1	GO:0072283	mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003337) metanephric renal vesicle morphogenesis(GO:0072283)
0.0	0.0	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.0	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.3	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.0	0.0	GO:0042482	positive regulation of odontogenesis(GO:0042482) positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0060029	convergent extension involved in organogenesis(GO:0060029)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.0	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.0	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.0	GO:0033033	negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0006853	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.1	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.0	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.0	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.0	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.0	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.0	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.0	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.2	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.0	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.1	GO:0098876	Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0	0.0	GO:0048368	lateral mesoderm development(GO:0048368)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0010324	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0031103	axon regeneration(GO:0031103)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.1	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.0	GO:0031946	regulation of ketone biosynthetic process(GO:0010566) regulation of glucocorticoid biosynthetic process(GO:0031946) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347) regulation of steroid hormone biosynthetic process(GO:0090030)
0.0	0.0	GO:0015838	amino-acid betaine transport(GO:0015838) carnitine transport(GO:0015879)
0.0	0.1	GO:0043277	apoptotic cell clearance(GO:0043277)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.0	GO:0031392	negative regulation of female receptivity(GO:0007621) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.0	0.2	GO:0006024	glycosaminoglycan biosynthetic process(GO:0006024)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.2	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0030315	T-tubule(GO:0030315)
0.0	0.0	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.6	GO:0044853	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.2	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.3	GO:0005581	collagen trimer(GO:0005581)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.0	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0048495	Roundabout binding(GO:0048495)
0.1	0.2	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.2	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.2	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0035241	protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.2	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.4	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.3	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.1	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.2	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.0	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.0	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.0	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.3	GO:0032934	sterol binding(GO:0032934)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.0	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.0	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.0	GO:0016406	carnitine O-acyltransferase activity(GO:0016406)
0.0	0.1	GO:0070888	E-box binding(GO:0070888)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.2	GO:0017046	peptide hormone binding(GO:0017046)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.0	GO:0050897	cobalt ion binding(GO:0050897)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.8	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.3	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.2	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin