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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SHOX

Z-value: 0.52

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Transcription factors associated with SHOX

Gene Symbol	Gene ID	Gene Info
SHOX Ensembl NCBI GeneCards UniProt	ENSG00000185960.8	SHOX
SHOX Ensembl NCBI GeneCards UniProt	ENSGR0000185960.8	SHOX

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SHOX	chrX_596485_596762	5081	0.343512	0.70	3.5e-02	Click!
SHOX	chrX_897740_897891	306273	0.011882	-0.68	4.5e-02	Click!
SHOX	chrX_817887_818038	226420	0.021250	-0.65	5.6e-02	Click!
SHOX	chrX_802713_802864	211246	0.024187	-0.54	1.3e-01	Click!
SHOX	chrX_951756_951907	360289	0.008585	-0.54	1.3e-01	Click!

Activity of the SHOX motif across conditions

Conditions sorted by the z-value of the SHOX motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_104904746_104905919	0.54	CASP1	caspase 1, apoptosis-related cysteine peptidase	508	0.77
chrX_78400540_78401325	0.39	GPR174	G protein-coupled receptor 174	25537	0.27
chr1_113164228_113164419	0.30	ST7L	suppression of tumorigenicity 7 like	2283	0.19
chr6_159464766_159465080	0.29	TAGAP	T-cell activation RhoGTPase activating protein	1127	0.51
chr5_58055562_58056142	0.29	RP11-479O16.1		24754	0.24
chr6_154568354_154568864	0.28	IPCEF1	interaction protein for cytohesin exchange factors 1	53	0.99
chr9_92032170_92032321	0.26	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	1503	0.49
chr1_180387724_180387875	0.26	ENSG00000265435	.	19726	0.22
chr1_200865204_200865355	0.26	C1orf106	chromosome 1 open reading frame 106	1330	0.42
chr10_33425652_33425891	0.26	ENSG00000263576	.	38207	0.16
chr6_159071306_159071615	0.26	SYTL3	synaptotagmin-like 3	414	0.83
chr13_99910339_99910626	0.26	GPR18	G protein-coupled receptor 18	146	0.96
chr4_36245078_36245884	0.25	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	80	0.74
chr13_31309966_31310295	0.25	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	485	0.88
chr7_32929941_32930760	0.25	KBTBD2	kelch repeat and BTB (POZ) domain containing 2	415	0.87
chr1_197730742_197731002	0.25	RP11-448G4.4		4423	0.25
chr5_130882612_130883040	0.25	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	14100	0.29
chr9_135038389_135038692	0.25	NTNG2	netrin G2	1206	0.56
chr15_96817385_96817602	0.24	NR2F2-AS1	NR2F2 antisense RNA 1	1732	0.37
chr1_244504765_244505074	0.24	C1orf100	chromosome 1 open reading frame 100	11018	0.25
chr5_81074467_81075538	0.24	SSBP2	single-stranded DNA binding protein 2	27930	0.25
chr1_226251298_226251924	0.24	H3F3A	H3 histone, family 3A	67	0.97
chrX_25020829_25021251	0.23	ARX	aristaless related homeobox	13025	0.26
chr14_22947593_22947744	0.23	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	2372	0.15
chr12_95071864_95072096	0.23	TMCC3	transmembrane and coiled-coil domain family 3	27642	0.23
chr12_66583583_66583798	0.23	IRAK3	interleukin-1 receptor-associated kinase 3	653	0.67
chr11_46581548_46581763	0.23	AMBRA1	autophagy/beclin-1 regulator 1	31259	0.15
chr8_27131821_27132033	0.23	STMN4	stathmin-like 4	15990	0.18
chr7_33078848_33079779	0.23	NT5C3A	5'-nucleotidase, cytosolic IIIA	1208	0.42
chr10_12064652_12064803	0.23	UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	13169	0.19
chr11_104915569_104916017	0.22	CARD16	caspase recruitment domain family, member 16	241	0.92
chr8_39259417_39259568	0.22	ENSG00000252176	.	158964	0.04
chr13_86159310_86159559	0.22	ENSG00000207012	.	446	0.91
chr2_61111507_61111691	0.22	REL	v-rel avian reticuloendotheliosis viral oncogene homolog	2808	0.27
chr18_74781332_74781483	0.22	MBP	myelin basic protein	35810	0.21
chr2_213962198_213962349	0.22	IKZF2	IKAROS family zinc finger 2 (Helios)	51080	0.16
chr13_38923188_38923622	0.21	UFM1	ubiquitin-fold modifier 1	583	0.86
chr20_21080465_21081932	0.21	ENSG00000199509	.	38517	0.18
chr1_39594945_39595096	0.21	ENSG00000206654	.	8305	0.17
chrX_19815653_19816006	0.21	SH3KBP1	SH3-domain kinase binding protein 1	2040	0.46
chr22_31615175_31615326	0.21	ENSG00000199695	.	3589	0.13
chr18_32630496_32630927	0.20	MAPRE2	microtubule-associated protein, RP/EB family, member 2	9097	0.3
chr10_134261699_134261957	0.20	C10orf91	chromosome 10 open reading frame 91	3135	0.24
chr7_50345819_50346403	0.20	IKZF1	IKAROS family zinc finger 1 (Ikaros)	1733	0.5
chr5_98362961_98363596	0.20	ENSG00000200351	.	90827	0.09
chr16_71935673_71935824	0.20	IST1	increased sodium tolerance 1 homolog (yeast)	6256	0.13
chr1_112283056_112283209	0.20	FAM212B-AS1	FAM212B antisense RNA 1	657	0.55
chr16_50776896_50777610	0.20	RP11-327F22.1		527	0.39
chr4_90226799_90226950	0.20	GPRIN3	GPRIN family member 3	2287	0.45
chr4_38623548_38623699	0.20	RP11-617D20.1		2573	0.31
chr13_84126063_84126363	0.20	ENSG00000222791	.	253911	0.02
chr1_1099465_1099616	0.20	ENSG00000207730	.	2944	0.11
chr14_91863541_91863979	0.20	CCDC88C	coiled-coil domain containing 88C	19930	0.21
chr13_38505809_38505960	0.20	TRPC4	transient receptor potential cation channel, subfamily C, member 4	61322	0.14
chr2_51905023_51905174	0.19	ENSG00000222692	.	242742	0.02
chr14_90082198_90082485	0.19	FOXN3	forkhead box N3	3133	0.18
chr2_64244915_64245982	0.19	VPS54	vacuolar protein sorting 54 homolog (S. cerevisiae)	758	0.76
chr13_40532306_40532606	0.19	ENSG00000212553	.	101092	0.08
chr1_43151006_43151188	0.19	YBX1	Y box binding protein 1	2439	0.25
chr1_25887785_25888064	0.19	LDLRAP1	low density lipoprotein receptor adaptor protein 1	17853	0.19
chr4_68636095_68636246	0.19	GNRHR	gonadotropin-releasing hormone receptor	16092	0.17
chrX_118815979_118816490	0.19	SEPT6	septin 6	10558	0.17
chr13_41555714_41555943	0.19	ELF1	E74-like factor 1 (ets domain transcription factor)	590	0.77
chr12_10019991_10020525	0.19	RP11-290C10.1		632	0.61
chr3_32996346_32996497	0.18	CCR4	chemokine (C-C motif) receptor 4	3355	0.33
chr1_246488003_246488154	0.18	SMYD3-IT1	SMYD3 intronic transcript 1 (non-protein coding)	2338	0.35
chr12_4385579_4385730	0.18	CCND2-AS1	CCND2 antisense RNA 1	304	0.58
chr12_114029519_114029670	0.18	ENSG00000238487	.	11064	0.26
chr14_35306917_35307068	0.18	ENSG00000251726	.	7574	0.17
chr8_10268256_10268407	0.18	RP11-981G7.1		22851	0.2
chr3_168442261_168442412	0.18	ENSG00000207717	.	172694	0.04
chr3_128899189_128899802	0.18	CNBP	CCHC-type zinc finger, nucleic acid binding protein	3247	0.18
chr12_9912992_9913534	0.18	CD69	CD69 molecule	234	0.92
chr2_194212623_194212914	0.18	NA	NA	> 10⁶	NA
chr20_43597121_43597440	0.18	STK4	serine/threonine kinase 4	2113	0.25
chr19_42390602_42391041	0.17	ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	2306	0.19
chr1_24862040_24862255	0.17	ENSG00000266551	.	5943	0.18
chrX_10066246_10067411	0.17	WWC3	WWC family member 3	35329	0.15
chr6_41528112_41529137	0.17	FOXP4	forkhead box P4	4863	0.19
chr21_36772703_36772854	0.17	ENSG00000211590	.	320235	0.01
chr5_95457669_95457820	0.17	ENSG00000207578	.	42902	0.17
chr21_32567568_32567719	0.17	TIAM1	T-cell lymphoma invasion and metastasis 1	65104	0.13
chr3_172240144_172241280	0.17	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	553	0.83
chr2_64441014_64441273	0.17	AC074289.1		7034	0.28
chr10_70850849_70851349	0.17	SRGN	serglycin	3225	0.25
chr11_119572371_119572522	0.17	PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	26817	0.16
chr12_32872481_32872632	0.17	ENSG00000201563	.	14116	0.21
chr9_37921534_37921685	0.17	ENSG00000251745	.	15156	0.2
chr1_198615140_198615291	0.17	PTPRC	protein tyrosine phosphatase, receptor type, C	6923	0.25
chr6_26198173_26198564	0.17	HIST1H3D	histone cluster 1, H3d	890	0.22
chr1_169679248_169679951	0.17	SELL	selectin L	1240	0.48
chr15_93999319_93999470	0.17	ENSG00000212063	.	169842	0.04
chr16_18957307_18957806	0.17	ENSG00000265515	.	15952	0.13
chr12_12510418_12511218	0.17	LOH12CR1	loss of heterozygosity, 12, chromosomal region 1	466	0.63
chr11_88068800_88069370	0.17	CTSC	cathepsin C	1816	0.49
chr3_151961363_151961565	0.17	MBNL1	muscleblind-like splicing regulator 1	24365	0.2
chr14_22968352_22968523	0.17	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	12266	0.1
chr1_21349011_21349508	0.17	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	28136	0.19
chr2_68961577_68961872	0.16	ARHGAP25	Rho GTPase activating protein 25	189	0.96
chr3_67581837_67581988	0.16	SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	3266	0.41
chr3_69140694_69141185	0.16	ARL6IP5	ADP-ribosylation-like factor 6 interacting protein 5	6767	0.15
chr1_192546230_192546423	0.16	RGS1	regulator of G-protein signaling 1	1423	0.45
chr1_198627689_198627922	0.16	RP11-553K8.5		8385	0.25
chr6_130391698_130391967	0.16	L3MBTL3	l(3)mbt-like 3 (Drosophila)	50130	0.15
chr2_8135764_8135915	0.16	ENSG00000221255	.	418867	0.01
chr11_42259823_42259974	0.16	LRRC4C	leucine rich repeat containing 4C	778575	0.0
chr7_129620661_129620812	0.16	ENSG00000263557	.	4851	0.14
chr9_20242645_20242902	0.16	ENSG00000221744	.	52229	0.16
chr7_94035982_94036133	0.16	COL1A2	collagen, type I, alpha 2	12184	0.27
chr17_66031093_66031463	0.16	KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	357	0.87
chr9_102849500_102849651	0.16	ERP44	endoplasmic reticulum protein 44	11747	0.18
chr15_52844361_52844512	0.16	ARPP19	cAMP-regulated phosphoprotein, 19kDa	5505	0.2
chr10_1779633_1779784	0.16	ADARB2	adenosine deaminase, RNA-specific, B2 (non-functional)	38	0.99
chr16_31271922_31272073	0.16	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	682	0.53
chr2_55986068_55986219	0.16	PNPT1	polyribonucleotide nucleotidyltransferase 1	65098	0.11
chr13_33608099_33608250	0.16	ENSG00000221677	.	7315	0.24
chr12_64798382_64799443	0.16	XPOT	exportin, tRNA	86	0.97
chr5_56496018_56496179	0.16	GPBP1	GC-rich promoter binding protein 1	13850	0.23
chr2_174129320_174129481	0.16	MLK7-AS1	MLK7 antisense RNA 1	6948	0.3
chr12_66629583_66630042	0.16	ENSG00000266539	.	410	0.82
chr14_22966536_22967037	0.15	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	10615	0.1
chr15_60881660_60881911	0.15	RORA	RAR-related orphan receptor A	2955	0.3
chr6_25041553_25042305	0.15	RP3-425P12.5		138	0.72
chr10_129861850_129862130	0.15	PTPRE	protein tyrosine phosphatase, receptor type, E	16156	0.26
chr1_227501319_227501470	0.15	CDC42BPA	CDC42 binding protein kinase alpha (DMPK-like)	3489	0.36
chr14_52778615_52778779	0.15	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	2326	0.38
chr4_154411300_154411567	0.15	KIAA0922	KIAA0922	23932	0.22
chr11_64089315_64089466	0.15	PRDX5	peroxiredoxin 5	3736	0.08
chr16_24741428_24741975	0.15	TNRC6A	trinucleotide repeat containing 6A	667	0.8
chr2_82727930_82728081	0.15	ENSG00000201311	.	193713	0.03
chr4_84161976_84162127	0.15	COQ2	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	43867	0.16
chr3_43329409_43329595	0.15	SNRK	SNF related kinase	1424	0.43
chr10_30745504_30745655	0.15	MAP3K8	mitogen-activated protein kinase kinase kinase 8	17828	0.21
chr2_192540821_192541028	0.15	NABP1	nucleic acid binding protein 1	1938	0.47
chr10_3514525_3515428	0.15	RP11-184A2.3		278283	0.01
chr18_3329157_3329308	0.15	MYL12B	myosin, light chain 12B, regulatory	66278	0.09
chr7_140014228_140014507	0.15	SLC37A3	solute carrier family 37, member 3	28922	0.14
chr1_186292481_186292673	0.15	ENSG00000202025	.	11517	0.17
chr4_140587624_140588180	0.15	MGST2	microsomal glutathione S-transferase 2	913	0.61
chr16_69598825_69599558	0.15	NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	194	0.82
chr7_106507057_106507208	0.15	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1208	0.59
chr5_131762557_131762944	0.15	AC116366.5		344	0.83
chr14_91881184_91881623	0.15	CCDC88C	coiled-coil domain containing 88C	2287	0.37
chr2_215664874_215665025	0.15	BARD1	BRCA1 associated RING domain 1	9448	0.21
chr5_57787350_57787738	0.15	GAPT	GRB2-binding adaptor protein, transmembrane	280	0.92
chr12_65779210_65779361	0.15	MSRB3	methionine sulfoxide reductase B3	58630	0.15
chr4_40201423_40201705	0.14	RHOH	ras homolog family member H	400	0.87
chr3_189510811_189510962	0.14	TP63	tumor protein p63	3296	0.33
chr12_53773389_53773606	0.14	SP1	Sp1 transcription factor	463	0.73
chr6_143140776_143141820	0.14	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	16886	0.26
chr15_75080868_75081404	0.14	ENSG00000264386	.	38	0.76
chr8_70622919_70623070	0.14	RP11-102F4.2		2631	0.31
chr11_58777091_58777242	0.14	RP11-142C4.6		30408	0.16
chr5_118653769_118653920	0.14	ENSG00000243333	.	11518	0.19
chr4_91603417_91603568	0.14	CCSER1	coiled-coil serine-rich protein 1	32830	0.25
chr2_192623983_192624134	0.14	AC098872.3		34093	0.19
chr1_19804030_19804234	0.14	CAPZB	capping protein (actin filament) muscle Z-line, beta	6447	0.18
chr22_46883179_46883330	0.14	CELSR1	cadherin, EGF LAG seven-pass G-type receptor 1	47937	0.14
chr11_104838069_104839428	0.14	CASP4	caspase 4, apoptosis-related cysteine peptidase	1345	0.45
chr2_37576303_37576454	0.14	QPCT	glutaminyl-peptide cyclotransferase	4526	0.2
chr9_137347658_137347902	0.14	RXRA	retinoid X receptor, alpha	49352	0.15
chr17_47819247_47819793	0.14	FAM117A	family with sequence similarity 117, member A	17631	0.14
chr1_118149801_118150025	0.14	FAM46C	family with sequence similarity 46, member C	1357	0.38
chr5_133558015_133558734	0.14	PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	1710	0.28
chr16_86530318_86530469	0.14	FOXF1	forkhead box F1	13740	0.21
chr17_29637369_29637894	0.14	EVI2B	ecotropic viral integration site 2B	3471	0.16
chr13_50265965_50266116	0.14	EBPL	emopamil binding protein-like	429	0.85
chr14_35763502_35763691	0.14	PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	1917	0.35
chr1_225610206_225610357	0.14	LBR	lamin B receptor	5318	0.2
chr8_110619590_110619741	0.14	SYBU	syntabulin (syntaxin-interacting)	639	0.72
chr14_99708318_99708739	0.14	AL109767.1		20757	0.2
chr4_25915201_25915609	0.14	SMIM20	small integral membrane protein 20	421	0.89
chr21_32559881_32560032	0.14	TIAM1	T-cell lymphoma invasion and metastasis 1	57417	0.15
chr7_26141262_26141558	0.14	ENSG00000266430	.	41451	0.15
chr15_55547653_55548107	0.14	RAB27A	RAB27A, member RAS oncogene family	6647	0.22
chr10_27129753_27129904	0.14	ABI1	abl-interactor 1	19964	0.17
chr17_56736328_56736479	0.14	ENSG00000202077	.	263	0.86
chr15_101783225_101783409	0.14	CHSY1	chondroitin sulfate synthase 1	8820	0.18
chr6_105709183_105709334	0.14	RP3-355L5.4		17633	0.19
chr17_21157480_21157631	0.14	C17orf103	chromosome 17 open reading frame 103	833	0.56
chr12_54891959_54892179	0.14	NCKAP1L	NCK-associated protein 1-like	499	0.73
chr9_125662893_125663901	0.14	RC3H2	ring finger and CCCH-type domains 2	3008	0.16
chr3_152002678_152002963	0.14	MBNL1	muscleblind-like splicing regulator 1	14374	0.21
chr1_162205339_162205490	0.14	ENSG00000266144	.	78517	0.08
chr4_48951470_48951621	0.14	ENSG00000252913	.	16674	0.19
chr11_34645064_34645215	0.14	EHF	ets homologous factor	668	0.8
chr6_106972751_106973424	0.14	AIM1	absent in melanoma 1	13357	0.2
chr15_93351955_93352146	0.14	CTD-2313J17.1		253	0.85
chr9_132175083_132175284	0.14	ENSG00000242281	.	42443	0.14
chr15_52361483_52361634	0.14	CTD-2184D3.5		31162	0.12
chr7_156761668_156761819	0.14	NOM1	nucleolar protein with MIF4G domain 1	19326	0.16
chr1_16483683_16483834	0.14	EPHA2	EPH receptor A2	1176	0.29
chr8_26184784_26184935	0.14	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	33860	0.18
chr2_204721096_204721247	0.14	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11338	0.25
chr10_92074085_92074236	0.14	ENSG00000222451	.	150443	0.05
chr21_18884161_18884312	0.14	CXADR	coxsackie virus and adenovirus receptor	464	0.77
chr4_177191568_177191827	0.14	ASB5	ankyrin repeat and SOCS box containing 5	1324	0.49
chr18_33057581_33058355	0.14	INO80C	INO80 complex subunit C	9466	0.21
chr12_15112961_15113206	0.14	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	1117	0.46
chr7_91705589_91705740	0.14	AKAP9	A kinase (PRKA) anchor protein 9	6212	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1	0.3	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.3	GO:0071569	protein ufmylation(GO:0071569)
0.1	0.2	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.2	GO:0010040	response to iron(II) ion(GO:0010040)
0.1	0.2	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.1	0.3	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.1	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.1	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.2	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.2	GO:0045588	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.4	GO:0015671	oxygen transport(GO:0015671)
0.0	0.4	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.2	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.1	GO:2000351	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.0	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.2	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0042663	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.9	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0010832	negative regulation of myotube differentiation(GO:0010832)
0.0	0.1	GO:0055022	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.0	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.2	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.2	GO:0036230	granulocyte activation(GO:0036230)
0.0	0.3	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.0	GO:0001743	optic placode formation(GO:0001743)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.2	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.0	0.0	GO:0045605	negative regulation of epidermal cell differentiation(GO:0045605)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.0	0.2	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.0	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0043552	regulation of phosphatidylinositol 3-kinase activity(GO:0043551) positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.0	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.0	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.0	GO:1903960	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0031440	regulation of mRNA 3'-end processing(GO:0031440)
0.0	0.1	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.1	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0021853	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.2	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.0	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.0	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.0	0.1	GO:0042416	dopamine biosynthetic process(GO:0042416)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.0	GO:0031665	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.0	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.0	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.0	0.0	GO:1900078	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.0	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0070307	lens fiber cell development(GO:0070307)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.0	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.0	GO:0060291	long-term synaptic potentiation(GO:0060291)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.3	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.0	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.3	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.1	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.0	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.2	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.0	0.7	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.1	GO:0015781	pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.0	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.2	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.0	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.0	GO:0046049	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.0	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.2	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.0	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.0	GO:0046881	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.0	GO:0060462	lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.2	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.2	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.2	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.0	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0032811	negative regulation of epinephrine secretion(GO:0032811)
0.0	0.0	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0031958	corticosteroid receptor signaling pathway(GO:0031958)
0.0	0.2	GO:0019079	viral genome replication(GO:0019079)
0.0	0.0	GO:0045359	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.0	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.2	GO:0002429	immune response-activating cell surface receptor signaling pathway(GO:0002429)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.0	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.2	GO:0035195	gene silencing by miRNA(GO:0035195)
0.0	0.0	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.0	GO:0051571	positive regulation of histone H3-K4 methylation(GO:0051571)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.3	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.3	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.2	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0016580	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.0	GO:0070820	tertiary granule(GO:0070820)
0.0	0.2	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.2	GO:0005844	polysome(GO:0005844)
0.0	0.1	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.0	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0045335	phagocytic vesicle(GO:0045335)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.0	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.5	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.1	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0005732	small nucleolar ribonucleoprotein complex(GO:0005732)
0.0	0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0008180	COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.3	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.9	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.4	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.2	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.5	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.4	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.2	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.3	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.3	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.2	GO:0004000	adenosine deaminase activity(GO:0004000)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.0	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.0	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.0	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.0	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.2	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.0	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.0	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.2	GO:0005048	signal sequence binding(GO:0005048)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.0	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.5	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.0	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.3	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.0	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.0	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.3	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.0	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.0	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.6	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.0	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.1	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0	0.2	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.0	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.0	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
1.1	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.7	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5	PID TRAIL PATHWAY	TRAIL signaling pathway
0.3	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
1.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.3	PID EPO PATHWAY	EPO signaling pathway
0.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.3	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.1	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.6	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.5	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.4	PID IL12 2PATHWAY	IL12-mediated signaling events
0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.2	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	PID IL2 1PATHWAY	IL2-mediated signaling events
0.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	PID ALK1 PATHWAY	ALK1 signaling events
0.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.2	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.3	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.1	SIG CD40PATHWAYMAP	Genes related to CD40 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	0.6	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.5	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	0.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.3	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.5	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.4	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.4	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.1	REACTOME GAB1 SIGNALOSOME	Genes involved in GAB1 signalosome
0.0	0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.4	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.3	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.9	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.4	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.1	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.0	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.3	REACTOME PI3K AKT ACTIVATION	Genes involved in PI3K/AKT activation
0.0	0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.0	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.2	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.3	REACTOME RNA POL I TRANSCRIPTION	Genes involved in RNA Polymerase I Transcription
0.0	0.0	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling