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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SIX1_SIX3_SIX2

Z-value: 1.68

Motif logo

Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol	Gene ID	Gene Info
SIX1 Ensembl NCBI GeneCards UniProt	ENSG00000126778.7	SIX1
SIX3 Ensembl NCBI GeneCards UniProt	ENSG00000138083.3	SIX3
SIX2 Ensembl NCBI GeneCards UniProt	ENSG00000170577.7	SIX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SIX1	chr14_61109318_61109469	6787	0.224023	-0.82	6.5e-03	Click!
SIX1	chr14_61113971_61114451	1969	0.367365	-0.73	2.5e-02	Click!
SIX1	chr14_61116322_61116473	217	0.946641	-0.72	3.0e-02	Click!
SIX1	chr14_61123462_61124719	887	0.641189	-0.68	4.4e-02	Click!
SIX1	chr14_61116520_61116671	415	0.866959	-0.67	4.9e-02	Click!
SIX2	chr2_45241005_45241270	4568	0.304529	-0.71	3.2e-02	Click!
SIX2	chr2_45235607_45236412	560	0.835356	-0.70	3.6e-02	Click!
SIX2	chr2_45236575_45236726	81	0.982179	-0.69	3.9e-02	Click!
SIX2	chr2_45405843_45405994	169349	0.035597	-0.69	4.0e-02	Click!
SIX2	chr2_45395914_45396553	159664	0.039346	-0.67	4.9e-02	Click!
SIX3	chr2_45168726_45169073	3	0.605121	0.07	8.6e-01	Click!

Activity of the SIX1_SIX3_SIX2 motif across conditions

Conditions sorted by the z-value of the SIX1_SIX3_SIX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_42056193_42056486	0.80	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	453	0.8
chr2_106775791_106775996	0.66	UXS1	UDP-glucuronate decarboxylase 1	1147	0.57
chr12_29255881_29256032	0.64	ENSG00000222481	.	17859	0.25
chr14_22949288_22949494	0.64	ENSG00000251002	.	887	0.35
chr6_26442034_26442281	0.64	BTN3A3	butyrophilin, subfamily 3, member A3	1371	0.29
chr4_77910622_77910773	0.63	SEPT11	septin 11	4520	0.28
chr6_76203816_76203967	0.61	FILIP1	filamin A interacting protein 1	437	0.83
chr6_151562009_151562901	0.60	AKAP12	A kinase (PRKA) anchor protein 12	946	0.51
chr2_208390303_208390479	0.59	CREB1	cAMP responsive element binding protein 1	4070	0.24
chr20_62643605_62643756	0.59	ZNF512B	zinc finger protein 512B	26258	0.07
chrX_13268074_13268225	0.58	GS1-600G8.3		60622	0.13
chr20_62643970_62644121	0.57	ZNF512B	zinc finger protein 512B	25893	0.07
chr7_5728695_5728919	0.56	RNF216-IT1	RNF216 intronic transcript 1 (non-protein coding)	8715	0.21
chr17_74749298_74749501	0.56	ENSG00000200257	.	405	0.71
chr8_29958413_29958564	0.54	LEPROTL1	leptin receptor overlapping transcript-like 1	968	0.49
chr16_84802144_84802295	0.54	USP10	ubiquitin specific peptidase 10	346	0.89
chr3_50645256_50645407	0.53	CISH	cytokine inducible SH2-containing protein	3872	0.17
chr6_128255928_128256079	0.52	THEMIS	thymocyte selection associated	16227	0.26
chr1_210004793_210004944	0.51	DIEXF	digestive organ expansion factor homolog (zebrafish)	3516	0.21
chrX_101409617_101409776	0.51	BEX5	brain expressed, X-linked 5	1066	0.45
chr7_130637471_130637622	0.48	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	31322	0.2
chr2_158296564_158297076	0.48	CYTIP	cytohesin 1 interacting protein	894	0.5
chr12_47604790_47604941	0.46	PCED1B	PC-esterase domain containing 1B	5187	0.24
chr2_219761502_219762270	0.45	WNT10A	wingless-type MMTV integration site family, member 10A	15003	0.11
chr4_56276034_56276185	0.44	ENSG00000239040	.	2694	0.22
chr14_23013027_23013178	0.44	AE000662.92	Uncharacterized protein	12432	0.1
chr4_40178201_40178376	0.44	RP11-395I6.3		9993	0.19
chr7_130627058_130627209	0.44	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	41735	0.17
chr14_22695818_22695969	0.43	ENSG00000238634	.	85006	0.09
chrX_15756367_15757484	0.43	CA5B	carbonic anhydrase VB, mitochondrial	532	0.77
chr4_113912419_113912570	0.43	RP11-650J17.2		43213	0.15
chr10_125828390_125828541	0.43	CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	22224	0.25
chr7_150216886_150217185	0.43	GIMAP7	GTPase, IMAP family member 7	5117	0.21
chr5_40686354_40686614	0.43	PTGER4	prostaglandin E receptor 4 (subtype EP4)	6884	0.22
chr9_77707832_77707983	0.43	OSTF1	osteoclast stimulating factor 1	4448	0.21
chr11_29141848_29142035	0.42	ENSG00000211499	.	156295	0.04
chr6_125064729_125064880	0.42	RNF217	ring finger protein 217	218887	0.02
chr12_24967868_24968019	0.42	RP11-625L16.3		15412	0.24
chr1_198614639_198614833	0.41	PTPRC	protein tyrosine phosphatase, receptor type, C	6444	0.26
chr9_134145569_134145886	0.41	FAM78A	family with sequence similarity 78, member A	153	0.95
chr10_116063923_116064706	0.41	VWA2	von Willebrand factor A domain containing 2	65225	0.11
chr5_139502851_139503002	0.41	IGIP	IgA-inducing protein	2595	0.21
chr15_52548772_52549093	0.40	ENSG00000221052	.	20465	0.17
chr9_115811998_115812149	0.40	ZFP37	ZFP37 zinc finger protein	6895	0.27
chr9_92786212_92786363	0.40	ENSG00000263967	.	470	0.9
chr12_57527559_57527864	0.40	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	1789	0.2
chr17_75373020_75373171	0.40	RP11-936I5.1		223	0.86
chr11_128911246_128911397	0.39	ENSG00000206847	.	10967	0.19
chr19_39728332_39728587	0.39	IFNL3	interferon, lambda 3	7187	0.12
chr6_143264256_143264520	0.39	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	1950	0.43
chr1_111210725_111210963	0.38	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	6811	0.19
chr6_136845943_136846225	0.38	MAP7	microtubule-associated protein 7	1037	0.53
chr1_84630171_84630563	0.37	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	3	0.99
chr4_143768164_143768496	0.37	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	255	0.96
chr1_111211265_111211483	0.37	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	6281	0.19
chr3_56949638_56949992	0.37	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	684	0.75
chr5_107438203_107438354	0.37	FBXL17	F-box and leucine-rich repeat protein 17	265377	0.02
chr1_186291918_186292069	0.37	ENSG00000202025	.	10933	0.17
chr20_35258352_35258894	0.37	SLA2	Src-like-adaptor 2	15661	0.12
chr3_152077898_152078049	0.37	TMEM14E	transmembrane protein 14E	19194	0.22
chr9_131318552_131318703	0.37	SPTAN1	spectrin, alpha, non-erythrocytic 1	3758	0.14
chr19_41813326_41813520	0.37	CCDC97	coiled-coil domain containing 97	2671	0.16
chr10_60336470_60336621	0.37	BICC1	bicaudal C homolog 1 (Drosophila)	63645	0.15
chr2_175710164_175710315	0.36	CHN1	chimerin 1	894	0.68
chr2_182321276_182321427	0.36	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	583	0.85
chr4_129732983_129734245	0.36	JADE1	jade family PHD finger 1	615	0.83
chr9_95474388_95474658	0.36	IPPK	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	41976	0.14
chr16_68773930_68774081	0.36	ENSG00000200558	.	2378	0.23
chr14_22783453_22783604	0.35	ENSG00000251002	.	118191	0.04
chr6_45463009_45463160	0.35	RUNX2	runt-related transcription factor 2	72862	0.11
chr12_6744335_6744486	0.35	LPAR5	lysophosphatidic acid receptor 5	1203	0.25
chr2_143887292_143887566	0.35	ARHGAP15	Rho GTPase activating protein 15	546	0.84
chr10_28621171_28621410	0.35	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	2125	0.36
chr1_61332097_61332364	0.35	NFIA	nuclear factor I/A	1299	0.6
chr14_61802494_61802645	0.34	PRKCH	protein kinase C, eta	8391	0.2
chr20_43110715_43110866	0.34	TTPAL	tocopherol (alpha) transfer protein-like	6230	0.13
chr9_110745973_110746124	0.34	ENSG00000222459	.	64789	0.14
chr6_33378848_33379665	0.34	PHF1	PHD finger protein 1	518	0.64
chr2_106355418_106355569	0.34	NCK2	NCK adaptor protein 2	5861	0.32
chr10_126430313_126430464	0.34	FAM53B	family with sequence similarity 53, member B	1151	0.46
chr4_119748782_119749072	0.34	SEC24D	SEC24 family member D	8366	0.28
chr9_130461454_130462084	0.34	C9orf117	chromosome 9 open reading frame 117	7502	0.11
chr11_806204_806355	0.34	PIDD	p53-induced death domain protein	1034	0.23
chr10_33424940_33425136	0.34	ENSG00000263576	.	37474	0.16
chr5_81365043_81365194	0.34	ATG10-AS1	ATG10 antisense RNA 1	4403	0.24
chr8_23075253_23075404	0.33	ENSG00000246582	.	6656	0.12
chr1_245316415_245317636	0.33	KIF26B	kinesin family member 26B	1262	0.47
chr2_225823561_225823839	0.33	DOCK10	dedicator of cytokinesis 10	11918	0.28
chr14_76298268_76298419	0.33	RP11-270M14.4		5211	0.29
chr1_32393915_32394066	0.33	PTP4A2	protein tyrosine phosphatase type IVA, member 2	8906	0.18
chr2_225750747_225750920	0.32	DOCK10	dedicator of cytokinesis 10	60949	0.15
chr11_70244216_70245100	0.32	CTTN	cortactin	11	0.53
chr13_46741429_46741580	0.32	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	1150	0.42
chr5_102098307_102098531	0.32	PAM	peptidylglycine alpha-amidating monooxygenase	7372	0.33
chr1_109597558_109597709	0.32	WDR47	WD repeat domain 47	12783	0.12
chr1_172748125_172748386	0.32	FASLG	Fas ligand (TNF superfamily, member 6)	120097	0.06
chr2_73496881_73497091	0.32	FBXO41	F-box protein 41	1057	0.43
chr11_118478413_118479735	0.31	PHLDB1	pleckstrin homology-like domain, family B, member 1	716	0.54
chr4_127820346_127820497	0.31	ENSG00000199862	.	128953	0.06
chr1_145427603_145427863	0.31	TXNIP	thioredoxin interacting protein	10736	0.12
chr9_117134390_117135168	0.31	AKNA	AT-hook transcription factor	4465	0.23
chr9_128408983_128409218	0.31	MAPKAP1	mitogen-activated protein kinase associated protein 1	3596	0.32
chr3_5231863_5232390	0.31	EDEM1	ER degradation enhancer, mannosidase alpha-like 1	2092	0.23
chr6_160842707_160842858	0.31	SLC22A3	solute carrier family 22 (organic cation transporter), member 3	73357	0.11
chr5_55786648_55786799	0.31	CTC-236F12.4	Uncharacterized protein	9127	0.21
chr1_25290384_25290732	0.31	RUNX3	runt-related transcription factor 3	917	0.57
chr1_118403883_118404183	0.31	GDAP2	ganglioside induced differentiation associated protein 2	68173	0.12
chr19_11160042_11160193	0.30	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	9394	0.14
chr6_45837974_45838125	0.30	CLIC5	chloride intracellular channel 5	145516	0.04
chr9_130614412_130614666	0.30	ENG	endoglin	2376	0.13
chr7_73509063_73509569	0.30	LIMK1	LIM domain kinase 1	1907	0.33
chr14_22309331_22309482	0.30	ENSG00000222776	.	60621	0.14
chr16_11676228_11676379	0.30	LITAF	lipopolysaccharide-induced TNF factor	3926	0.23
chr19_14551433_14551660	0.30	PKN1	protein kinase N1	474	0.7
chr9_81972295_81972446	0.30	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	214318	0.03
chr7_90798408_90798559	0.30	FZD1	frizzled family receptor 1	95300	0.09
chr18_2979843_2980201	0.30	LPIN2	lipin 2	2849	0.22
chr20_20724641_20724860	0.30	ENSG00000264361	.	5376	0.28
chr9_116282321_116282472	0.30	RGS3	regulator of G-protein signaling 3	2846	0.31
chr7_155326313_155326555	0.30	CNPY1	canopy FGF signaling regulator 1	99	0.97
chr6_138248657_138248808	0.30	RP11-356I2.4		59362	0.13
chr20_33871790_33873092	0.30	EIF6	eukaryotic translation initiation factor 6	77	0.88
chrX_130036036_130037401	0.30	ENOX2	ecto-NOX disulfide-thiol exchanger 2	460	0.9
chr5_89123597_89123748	0.30	ENSG00000264342	.	188865	0.03
chr9_89870217_89870368	0.30	ENSG00000212421	.	5073	0.33
chr17_73246169_73246352	0.30	GGA3	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	11098	0.09
chrX_70766986_70767137	0.29	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	10197	0.18
chr3_16342520_16342671	0.29	RP11-415F23.2		13351	0.16
chr5_130602420_130602583	0.29	CDC42SE2	CDC42 small effector 2	2708	0.39
chr2_12684277_12684428	0.29	ENSG00000207183	.	132725	0.05
chr15_78365295_78365472	0.29	TBC1D2B	TBC1 domain family, member 2B	4611	0.15
chr10_12085799_12085950	0.29	UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	851	0.6
chr6_53198691_53198842	0.29	ELOVL5	ELOVL fatty acid elongase 5	14821	0.2
chr7_50361038_50361265	0.29	IKZF1	IKAROS family zinc finger 1 (Ikaros)	6094	0.31
chr19_50836422_50837123	0.29	KCNC3	potassium voltage-gated channel, Shaw-related subfamily, member 3	0	0.95
chr1_115605656_115605807	0.29	TSPAN2	tetraspanin 2	26304	0.2
chr3_142227327_142227499	0.28	RP11-383G6.3		36234	0.13
chr22_34318362_34318970	0.28	LARGE	like-glycosyltransferase	82	0.74
chr10_63991622_63991773	0.28	RTKN2	rhotekin 2	4325	0.32
chr2_55379810_55379961	0.28	RTN4	reticulon 4	40128	0.12
chr18_27729065_27729216	0.28	ENSG00000221731	.	665847	0.0
chr15_55095080_55095231	0.28	UNC13C	unc-13 homolog C (C. elegans)	191482	0.03
chr8_125615976_125616127	0.28	RP11-532M24.1		24179	0.17
chr2_200899058_200899209	0.28	C2orf47	chromosome 2 open reading frame 47	78589	0.09
chr5_57368587_57368738	0.28	ENSG00000238899	.	2647	0.43
chrX_24484452_24484603	0.28	PDK3	pyruvate dehydrogenase kinase, isozyme 3	954	0.63
chr1_150484995_150485146	0.28	ECM1	extracellular matrix protein 1	4487	0.12
chr11_96073413_96073903	0.28	ENSG00000266192	.	944	0.55
chr2_161993456_161993757	0.28	TANK	TRAF family member-associated NFKB activator	140	0.97
chr11_62444789_62444940	0.28	UBXN1	UBX domain protein 1	591	0.42
chr11_36641126_36641415	0.28	RAG2	recombination activating gene 2	21484	0.19
chr1_29255082_29255406	0.28	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	14153	0.18
chr17_27467519_27468040	0.28	RP11-321A17.4		278	0.55
chr9_123606315_123606466	0.28	PSMD5-AS1	PSMD5 antisense RNA 1 (head to head)	601	0.6
chr5_75699014_75699893	0.28	IQGAP2	IQ motif containing GTPase activating protein 2	304	0.94
chr11_104951685_104951836	0.28	CASP1	caspase 1, apoptosis-related cysteine peptidase	20398	0.15
chr14_22565525_22565676	0.27	ENSG00000238634	.	45287	0.18
chr18_26676772_26676923	0.27	ENSG00000265730	.	1204	0.6
chr17_43486558_43486834	0.27	ARHGAP27	Rho GTPase activating protein 27	1056	0.39
chr15_81591495_81592151	0.27	IL16	interleukin 16	66	0.98
chr19_42391098_42391303	0.27	ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	2685	0.17
chr1_27945148_27945299	0.27	FGR	feline Gardner-Rasheed sarcoma viral oncogene homolog	5350	0.15
chr4_17205389_17205540	0.27	ENSG00000206780	.	117041	0.07
chr2_175462178_175462605	0.27	WIPF1	WAS/WASL interacting protein family, member 1	102	0.97
chr8_83009707_83009858	0.27	SNX16	sorting nexin 16	254681	0.02
chr8_125617266_125617519	0.27	RP11-532M24.1		25520	0.16
chr5_14268280_14268580	0.27	TRIO	trio Rho guanine nucleotide exchange factor	22656	0.28
chr16_3452838_3453133	0.27	ZNF174	zinc finger protein 174	1011	0.36
chr9_130855530_130855681	0.27	RP11-379C10.4		1131	0.27
chr7_94039789_94039940	0.27	COL1A2	collagen, type I, alpha 2	15991	0.25
chr3_32995541_32995692	0.27	CCR4	chemokine (C-C motif) receptor 4	2550	0.37
chr17_37931079_37931230	0.27	IKZF3	IKAROS family zinc finger 3 (Aiolos)	3324	0.18
chr16_1730441_1730592	0.26	HN1L	hematological and neurological expressed 1-like	178	0.89
chr20_62258641_62259758	0.26	CTD-3184A7.4		596	0.45
chrX_19815653_19816006	0.26	SH3KBP1	SH3-domain kinase binding protein 1	2040	0.46
chr6_109262468_109262619	0.26	ARMC2-AS1	ARMC2 antisense RNA 1	17237	0.2
chr3_115596546_115596697	0.26	ENSG00000243359	.	39906	0.22
chr4_154439708_154439859	0.26	KIAA0922	KIAA0922	37265	0.19
chr2_122660445_122660607	0.26	TSN	translin	146779	0.04
chr2_182322868_182323440	0.26	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	999	0.69
chrX_78201853_78202096	0.26	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	1056	0.69
chr17_56416209_56416360	0.26	BZRAP1-AS1	BZRAP1 antisense RNA 1	1565	0.24
chr17_74235344_74235495	0.26	RNF157	ring finger protein 157	963	0.47
chr3_187005158_187005309	0.26	MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	4252	0.27
chr13_52397484_52397635	0.26	RP11-327P2.5		19126	0.17
chr1_226922484_226922931	0.26	ITPKB	inositol-trisphosphate 3-kinase B	2452	0.34
chr4_41122983_41123211	0.26	ENSG00000207198	.	7138	0.23
chr17_42072137_42072373	0.26	PYY	peptide YY	9582	0.1
chr2_143905734_143905885	0.25	ARHGAP15	Rho GTPase activating protein 15	18926	0.23
chr4_7878163_7878536	0.25	AFAP1	actin filament associated protein 1	4309	0.28
chr1_155900220_155900371	0.25	KIAA0907	KIAA0907	3869	0.1
chr10_92434851_92435027	0.25	HTR7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	182516	0.03
chr6_26358532_26358683	0.25	ENSG00000252399	.	5343	0.1
chr3_56833713_56834040	0.25	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	2101	0.44
chr1_9777067_9777879	0.25	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	654	0.69
chr15_53096656_53097309	0.25	ONECUT1	one cut homeobox 1	14773	0.27
chr2_231200345_231200592	0.25	SP140L	SP140 nuclear body protein-like	6317	0.26
chr1_167484289_167484555	0.25	CD247	CD247 molecule	3353	0.26
chr9_139437724_139437875	0.25	RP11-413M3.4		466	0.63
chr6_37017654_37018643	0.25	COX6A1P2	cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2	5541	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.6	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.1	0.3	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.3	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.2	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1	0.3	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.1	0.2	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.2	GO:0003032	detection of oxygen(GO:0003032)
0.1	0.3	GO:0002664	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0	0.1	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.3	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.2	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.2	GO:0002921	negative regulation of humoral immune response(GO:0002921)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.2	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.2	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.2	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.6	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.1	GO:0061028	establishment of endothelial barrier(GO:0061028)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.3	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.2	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.2	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.2	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.1	GO:0039656	modulation by virus of host gene expression(GO:0039656)
0.0	0.2	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0060976	coronary vasculature development(GO:0060976)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.1	GO:0034653	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.2	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.1	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.2	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.2	GO:0071636	positive regulation of transforming growth factor beta production(GO:0071636)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.2	GO:0051926	negative regulation of calcium ion transport(GO:0051926)
0.0	0.1	GO:0046666	retinal cell programmed cell death(GO:0046666)
0.0	0.1	GO:0022011	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.0	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0	0.1	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.2	GO:0046716	muscle cell cellular homeostasis(GO:0046716)
0.0	0.1	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.0	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.2	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.1	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.1	GO:0090382	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.1	GO:0045901	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0006545	glycine biosynthetic process(GO:0006545)
0.0	0.0	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.2	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.4	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0045354	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0	0.1	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.0	GO:0060253	negative regulation of glial cell proliferation(GO:0060253)
0.0	0.0	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.1	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.0	GO:0060430	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.0	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.0	0.2	GO:0042255	ribosome assembly(GO:0042255)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0032071	regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.0	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:2001259	activation of store-operated calcium channel activity(GO:0032237) positive regulation of calcium ion transmembrane transporter activity(GO:1901021) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341) positive regulation of cation channel activity(GO:2001259)
0.0	0.0	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0051136	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.0	GO:0048541	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645) Peyer's patch development(GO:0048541)
0.0	0.0	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.2	GO:0071384	cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0	0.1	GO:0046719	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.0	GO:0072239	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	0.0	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.0	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.0	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0060122	inner ear receptor stereocilium organization(GO:0060122)
0.0	0.2	GO:0042308	negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein localization to nucleus(GO:1900181) negative regulation of protein import(GO:1904590)
0.0	0.0	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.0	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.0	GO:0008614	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.0	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.1	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.0	GO:0070170	regulation of tooth mineralization(GO:0070170)
0.0	0.1	GO:0045061	thymic T cell selection(GO:0045061)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.7	GO:0016579	protein deubiquitination(GO:0016579)
0.0	0.1	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.0	GO:1901798	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.0	GO:0071875	adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.0	GO:0033084	regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516) regulation of signal transduction by p53 class mediator(GO:1901796)
0.0	0.0	GO:0042940	D-amino acid transport(GO:0042940) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.0	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.0	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.0	GO:0060120	auditory receptor cell fate commitment(GO:0009912) auditory receptor cell fate determination(GO:0042668) inner ear receptor cell fate commitment(GO:0060120)
0.0	0.0	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.0	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.2	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.0	0.5	GO:0008360	regulation of cell shape(GO:0008360)
0.0	0.2	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.0	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.0	0.9	GO:0035023	regulation of Rho protein signal transduction(GO:0035023)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.3	GO:0019079	viral genome replication(GO:0019079)
0.0	0.5	GO:0030048	actin filament-based movement(GO:0030048)
0.0	0.3	GO:0051017	actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.0	0.1	GO:0050812	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.0	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.0	GO:0019049	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.0	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0	0.2	GO:0006730	one-carbon metabolic process(GO:0006730)
0.0	0.0	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.0	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0015840	urea transport(GO:0015840)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.6	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.3	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.4	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.3	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.3	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.1	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.6	GO:0098636	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.6	GO:0030175	filopodium(GO:0030175)
0.0	0.0	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0030893	meiotic cohesin complex(GO:0030893)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.0	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.2	GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.2	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.4	GO:0005884	actin filament(GO:0005884)
0.0	0.0	GO:0031904	endosome lumen(GO:0031904)
0.0	0.1	GO:0016580	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.0	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.6	GO:0030027	lamellipodium(GO:0030027)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0008179	adenylate cyclase binding(GO:0008179)
0.1	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.1	0.5	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.3	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.5	GO:0005522	profilin binding(GO:0005522)
0.1	0.2	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.2	GO:0042608	T cell receptor binding(GO:0042608)
0.1	0.2	GO:0031628	opioid receptor binding(GO:0031628)
0.1	0.2	GO:0016151	nickel cation binding(GO:0016151)
0.1	0.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.4	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.2	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.0	GO:0070052	collagen V binding(GO:0070052)
0.0	0.2	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.4	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.5	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.3	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.5	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.2	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.2	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.3	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.6	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.2	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.2	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.1	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.2	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.2	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.1	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	0.3	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.9	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.7	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.5	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.3	GO:0043022	ribosome binding(GO:0043022)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.0	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.0	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.2	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.0	GO:0051380	norepinephrine binding(GO:0051380)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.4	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.0	0.0	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.0	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.8	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.5	GO:0008375	acetylglucosaminyltransferase activity(GO:0008375)
0.0	0.1	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0032407	MutSalpha complex binding(GO:0032407)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.0	GO:1990939	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.1	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.0	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.2	GO:0051117	ATPase binding(GO:0051117)
0.0	0.0	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
1.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.4	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.5	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.3	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	PID S1P S1P4 PATHWAY	S1P4 pathway
0.5	PID REELIN PATHWAY	Reelin signaling pathway
0.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.8	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.0	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.2	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.7	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.8	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.5	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.4	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.4	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.2	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.3	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.2	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.9	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	REACTOME OPSINS	Genes involved in Opsins
0.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.1	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.5	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.2	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.1	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway