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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for SIX1_SIX3_SIX2

Z-value: 1.68

Motif logo

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Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol Gene ID Gene Info
SIX1
ENSG00000126778.7 SIX homeobox 1
SIX3
ENSG00000138083.3 SIX homeobox 3
SIX2
ENSG00000170577.7 SIX homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr14_61109318_61109469SIX167870.224023-0.826.5e-03Click!
chr14_61113971_61114451SIX119690.367365-0.732.5e-02Click!
chr14_61116322_61116473SIX12170.946641-0.723.0e-02Click!
chr14_61123462_61124719SIX18870.641189-0.684.4e-02Click!
chr14_61116520_61116671SIX14150.866959-0.674.9e-02Click!
chr2_45241005_45241270SIX245680.304529-0.713.2e-02Click!
chr2_45235607_45236412SIX25600.835356-0.703.6e-02Click!
chr2_45236575_45236726SIX2810.982179-0.693.9e-02Click!
chr2_45405843_45405994SIX21693490.035597-0.694.0e-02Click!
chr2_45395914_45396553SIX21596640.039346-0.674.9e-02Click!
chr2_45168726_45169073SIX330.6051210.078.6e-01Click!

Activity of the SIX1_SIX3_SIX2 motif across conditions

Conditions sorted by the z-value of the SIX1_SIX3_SIX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr19_42056193_42056486 0.80 CEACAM21
 carcinoembryonic antigen-related cell adhesion molecule 21
 453
 0.8
chr2_106775791_106775996 0.66 UXS1
 UDP-glucuronate decarboxylase 1
 1147
 0.57
chr12_29255881_29256032 0.64 ENSG00000222481
 .
 17859
 0.25
chr14_22949288_22949494 0.64 ENSG00000251002
 .
 887
 0.35
chr6_26442034_26442281 0.64 BTN3A3
 butyrophilin, subfamily 3, member A3
 1371
 0.29
chr4_77910622_77910773 0.63 SEPT11
 septin 11
 4520
 0.28
chr6_76203816_76203967 0.61 FILIP1
 filamin A interacting protein 1
 437
 0.83
chr6_151562009_151562901 0.60 AKAP12
 A kinase (PRKA) anchor protein 12
 946
 0.51
chr2_208390303_208390479 0.59 CREB1
 cAMP responsive element binding protein 1
 4070
 0.24
chr20_62643605_62643756 0.59 ZNF512B
 zinc finger protein 512B
 26258
 0.07
chrX_13268074_13268225 0.58 GS1-600G8.3
60622
 0.13
chr20_62643970_62644121 0.57 ZNF512B
 zinc finger protein 512B
 25893
 0.07
chr7_5728695_5728919 0.56 RNF216-IT1
 RNF216 intronic transcript 1 (non-protein coding)
 8715
 0.21
chr17_74749298_74749501 0.56 ENSG00000200257
 .
 405
 0.71
chr8_29958413_29958564 0.54 LEPROTL1
 leptin receptor overlapping transcript-like 1
 968
 0.49
chr16_84802144_84802295 0.54 USP10
 ubiquitin specific peptidase 10
 346
 0.89
chr3_50645256_50645407 0.53 CISH
 cytokine inducible SH2-containing protein
 3872
 0.17
chr6_128255928_128256079 0.52 THEMIS
 thymocyte selection associated
 16227
 0.26
chr1_210004793_210004944 0.51 DIEXF
 digestive organ expansion factor homolog (zebrafish)
 3516
 0.21
chrX_101409617_101409776 0.51 BEX5
 brain expressed, X-linked 5
 1066
 0.45
chr7_130637471_130637622 0.48 LINC-PINT
 long intergenic non-protein coding RNA, p53 induced transcript
 31322
 0.2
chr2_158296564_158297076 0.48 CYTIP
 cytohesin 1 interacting protein
 894
 0.5
chr12_47604790_47604941 0.46 PCED1B
 PC-esterase domain containing 1B
 5187
 0.24
chr2_219761502_219762270 0.45 WNT10A
 wingless-type MMTV integration site family, member 10A
 15003
 0.11
chr4_56276034_56276185 0.44 ENSG00000239040
 .
 2694
 0.22
chr14_23013027_23013178 0.44 AE000662.92
 Uncharacterized protein
 12432
 0.1
chr4_40178201_40178376 0.44 RP11-395I6.3
9993
 0.19
chr7_130627058_130627209 0.44 LINC-PINT
 long intergenic non-protein coding RNA, p53 induced transcript
 41735
 0.17
chr14_22695818_22695969 0.43 ENSG00000238634
 .
 85006
 0.09
chrX_15756367_15757484 0.43 CA5B
 carbonic anhydrase VB, mitochondrial
 532
 0.77
chr4_113912419_113912570 0.43 RP11-650J17.2
43213
 0.15
chr10_125828390_125828541 0.43 CHST15
 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
 22224
 0.25
chr7_150216886_150217185 0.43 GIMAP7
 GTPase, IMAP family member 7
 5117
 0.21
chr5_40686354_40686614 0.43 PTGER4
 prostaglandin E receptor 4 (subtype EP4)
 6884
 0.22
chr9_77707832_77707983 0.43 OSTF1
 osteoclast stimulating factor 1
 4448
 0.21
chr11_29141848_29142035 0.42 ENSG00000211499
 .
 156295
 0.04
chr6_125064729_125064880 0.42 RNF217
 ring finger protein 217
 218887
 0.02
chr12_24967868_24968019 0.42 RP11-625L16.3
15412
 0.24
chr1_198614639_198614833 0.41 PTPRC
 protein tyrosine phosphatase, receptor type, C
 6444
 0.26
chr9_134145569_134145886 0.41 FAM78A
 family with sequence similarity 78, member A
 153
 0.95
chr10_116063923_116064706 0.41 VWA2
 von Willebrand factor A domain containing 2
 65225
 0.11
chr5_139502851_139503002 0.41 IGIP
 IgA-inducing protein
 2595
 0.21
chr15_52548772_52549093 0.40 ENSG00000221052
 .
 20465
 0.17
chr9_115811998_115812149 0.40 ZFP37
 ZFP37 zinc finger protein
 6895
 0.27
chr9_92786212_92786363 0.40 ENSG00000263967
 .
 470
 0.9
chr12_57527559_57527864 0.40 STAT6
 signal transducer and activator of transcription 6, interleukin-4 induced
 1789
 0.2
chr17_75373020_75373171 0.40 RP11-936I5.1
223
 0.86
chr11_128911246_128911397 0.39 ENSG00000206847
 .
 10967
 0.19
chr19_39728332_39728587 0.39 IFNL3
 interferon, lambda 3
 7187
 0.12
chr6_143264256_143264520 0.39 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 1950
 0.43
chr1_111210725_111210963 0.38 KCNA3
 potassium voltage-gated channel, shaker-related subfamily, member 3
 6811
 0.19
chr6_136845943_136846225 0.38 MAP7
 microtubule-associated protein 7
 1037
 0.53
chr1_84630171_84630563 0.37 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
 3
 0.99
chr4_143768164_143768496 0.37 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 255
 0.96
chr1_111211265_111211483 0.37 KCNA3
 potassium voltage-gated channel, shaker-related subfamily, member 3
 6281
 0.19
chr3_56949638_56949992 0.37 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 684
 0.75
chr5_107438203_107438354 0.37 FBXL17
 F-box and leucine-rich repeat protein 17
 265377
 0.02
chr1_186291918_186292069 0.37 ENSG00000202025
 .
 10933
 0.17
chr20_35258352_35258894 0.37 SLA2
 Src-like-adaptor 2
 15661
 0.12
chr3_152077898_152078049 0.37 TMEM14E
 transmembrane protein 14E
 19194
 0.22
chr9_131318552_131318703 0.37 SPTAN1
 spectrin, alpha, non-erythrocytic 1
 3758
 0.14
chr19_41813326_41813520 0.37 CCDC97
 coiled-coil domain containing 97
 2671
 0.16
chr10_60336470_60336621 0.37 BICC1
 bicaudal C homolog 1 (Drosophila)
 63645
 0.15
chr2_175710164_175710315 0.36 CHN1
 chimerin 1
 894
 0.68
chr2_182321276_182321427 0.36 ITGA4
 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
 583
 0.85
chr4_129732983_129734245 0.36 JADE1
 jade family PHD finger 1
 615
 0.83
chr9_95474388_95474658 0.36 IPPK
 inositol 1,3,4,5,6-pentakisphosphate 2-kinase
 41976
 0.14
chr16_68773930_68774081 0.36 ENSG00000200558
 .
 2378
 0.23
chr14_22783453_22783604 0.35 ENSG00000251002
 .
 118191
 0.04
chr6_45463009_45463160 0.35 RUNX2
 runt-related transcription factor 2
 72862
 0.11
chr12_6744335_6744486 0.35 LPAR5
 lysophosphatidic acid receptor 5
 1203
 0.25
chr2_143887292_143887566 0.35 ARHGAP15
 Rho GTPase activating protein 15
 546
 0.84
chr10_28621171_28621410 0.35 MPP7
 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
 2125
 0.36
chr1_61332097_61332364 0.35 NFIA
 nuclear factor I/A
 1299
 0.6
chr14_61802494_61802645 0.34 PRKCH
 protein kinase C, eta
 8391
 0.2
chr20_43110715_43110866 0.34 TTPAL
 tocopherol (alpha) transfer protein-like
 6230
 0.13
chr9_110745973_110746124 0.34 ENSG00000222459
 .
 64789
 0.14
chr6_33378848_33379665 0.34 PHF1
 PHD finger protein 1
 518
 0.64
chr2_106355418_106355569 0.34 NCK2
 NCK adaptor protein 2
 5861
 0.32
chr10_126430313_126430464 0.34 FAM53B
 family with sequence similarity 53, member B
 1151
 0.46
chr4_119748782_119749072 0.34 SEC24D
 SEC24 family member D
 8366
 0.28
chr9_130461454_130462084 0.34 C9orf117
 chromosome 9 open reading frame 117
 7502
 0.11
chr11_806204_806355 0.34 PIDD
 p53-induced death domain protein
 1034
 0.23
chr10_33424940_33425136 0.34 ENSG00000263576
 .
 37474
 0.16
chr5_81365043_81365194 0.34 ATG10-AS1
 ATG10 antisense RNA 1
 4403
 0.24
chr8_23075253_23075404 0.33 ENSG00000246582
 .
 6656
 0.12
chr1_245316415_245317636 0.33 KIF26B
 kinesin family member 26B
 1262
 0.47
chr2_225823561_225823839 0.33 DOCK10
 dedicator of cytokinesis 10
 11918
 0.28
chr14_76298268_76298419 0.33 RP11-270M14.4
5211
 0.29
chr1_32393915_32394066 0.33 PTP4A2
 protein tyrosine phosphatase type IVA, member 2
 8906
 0.18
chr2_225750747_225750920 0.32 DOCK10
 dedicator of cytokinesis 10
 60949
 0.15
chr11_70244216_70245100 0.32 CTTN
 cortactin
 11
 0.53
chr13_46741429_46741580 0.32 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
 1150
 0.42
chr5_102098307_102098531 0.32 PAM
 peptidylglycine alpha-amidating monooxygenase
 7372
 0.33
chr1_109597558_109597709 0.32 WDR47
 WD repeat domain 47
 12783
 0.12
chr1_172748125_172748386 0.32 FASLG
 Fas ligand (TNF superfamily, member 6)
 120097
 0.06
chr2_73496881_73497091 0.32 FBXO41
 F-box protein 41
 1057
 0.43
chr11_118478413_118479735 0.31 PHLDB1
 pleckstrin homology-like domain, family B, member 1
 716
 0.54
chr4_127820346_127820497 0.31 ENSG00000199862
 .
 128953
 0.06
chr1_145427603_145427863 0.31 TXNIP
 thioredoxin interacting protein
 10736
 0.12
chr9_117134390_117135168 0.31 AKNA
 AT-hook transcription factor
 4465
 0.23
chr9_128408983_128409218 0.31 MAPKAP1
 mitogen-activated protein kinase associated protein 1
 3596
 0.32
chr3_5231863_5232390 0.31 EDEM1
 ER degradation enhancer, mannosidase alpha-like 1
 2092
 0.23
chr6_160842707_160842858 0.31 SLC22A3
 solute carrier family 22 (organic cation transporter), member 3
 73357
 0.11
chr5_55786648_55786799 0.31 CTC-236F12.4
 Uncharacterized protein
 9127
 0.21
chr1_25290384_25290732 0.31 RUNX3
 runt-related transcription factor 3
 917
 0.57
chr1_118403883_118404183 0.31 GDAP2
 ganglioside induced differentiation associated protein 2
 68173
 0.12
chr19_11160042_11160193 0.30 SMARCA4
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
 9394
 0.14
chr6_45837974_45838125 0.30 CLIC5
 chloride intracellular channel 5
 145516
 0.04
chr9_130614412_130614666 0.30 ENG
 endoglin
 2376
 0.13
chr7_73509063_73509569 0.30 LIMK1
 LIM domain kinase 1
 1907
 0.33
chr14_22309331_22309482 0.30 ENSG00000222776
 .
 60621
 0.14
chr16_11676228_11676379 0.30 LITAF
 lipopolysaccharide-induced TNF factor
 3926
 0.23
chr19_14551433_14551660 0.30 PKN1
 protein kinase N1
 474
 0.7
chr9_81972295_81972446 0.30 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 214318
 0.03
chr7_90798408_90798559 0.30 FZD1
 frizzled family receptor 1
 95300
 0.09
chr18_2979843_2980201 0.30 LPIN2
 lipin 2
 2849
 0.22
chr20_20724641_20724860 0.30 ENSG00000264361
 .
 5376
 0.28
chr9_116282321_116282472 0.30 RGS3
 regulator of G-protein signaling 3
 2846
 0.31
chr7_155326313_155326555 0.30 CNPY1
 canopy FGF signaling regulator 1
 99
 0.97
chr6_138248657_138248808 0.30 RP11-356I2.4
59362
 0.13
chr20_33871790_33873092 0.30 EIF6
 eukaryotic translation initiation factor 6
 77
 0.88
chrX_130036036_130037401 0.30 ENOX2
 ecto-NOX disulfide-thiol exchanger 2
 460
 0.9
chr5_89123597_89123748 0.30 ENSG00000264342
 .
 188865
 0.03
chr9_89870217_89870368 0.30 ENSG00000212421
 .
 5073
 0.33
chr17_73246169_73246352 0.30 GGA3
 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
 11098
 0.09
chrX_70766986_70767137 0.29 OGT
 O-linked N-acetylglucosamine (GlcNAc) transferase
 10197
 0.18
chr3_16342520_16342671 0.29 RP11-415F23.2
13351
 0.16
chr5_130602420_130602583 0.29 CDC42SE2
 CDC42 small effector 2
 2708
 0.39
chr2_12684277_12684428 0.29 ENSG00000207183
 .
 132725
 0.05
chr15_78365295_78365472 0.29 TBC1D2B
 TBC1 domain family, member 2B
 4611
 0.15
chr10_12085799_12085950 0.29 UPF2
 UPF2 regulator of nonsense transcripts homolog (yeast)
 851
 0.6
chr6_53198691_53198842 0.29 ELOVL5
 ELOVL fatty acid elongase 5
 14821
 0.2
chr7_50361038_50361265 0.29 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 6094
 0.31
chr19_50836422_50837123 0.29 KCNC3
 potassium voltage-gated channel, Shaw-related subfamily, member 3
 0
 0.95
chr1_115605656_115605807 0.29 TSPAN2
 tetraspanin 2
 26304
 0.2
chr3_142227327_142227499 0.28 RP11-383G6.3
36234
 0.13
chr22_34318362_34318970 0.28 LARGE
 like-glycosyltransferase
 82
 0.74
chr10_63991622_63991773 0.28 RTKN2
 rhotekin 2
 4325
 0.32
chr2_55379810_55379961 0.28 RTN4
 reticulon 4
 40128
 0.12
chr18_27729065_27729216 0.28 ENSG00000221731
 .
 665847
 0.0
chr15_55095080_55095231 0.28 UNC13C
 unc-13 homolog C (C. elegans)
 191482
 0.03
chr8_125615976_125616127 0.28 RP11-532M24.1
24179
 0.17
chr2_200899058_200899209 0.28 C2orf47
 chromosome 2 open reading frame 47
 78589
 0.09
chr5_57368587_57368738 0.28 ENSG00000238899
 .
 2647
 0.43
chrX_24484452_24484603 0.28 PDK3
 pyruvate dehydrogenase kinase, isozyme 3
 954
 0.63
chr1_150484995_150485146 0.28 ECM1
 extracellular matrix protein 1
 4487
 0.12
chr11_96073413_96073903 0.28 ENSG00000266192
 .
 944
 0.55
chr2_161993456_161993757 0.28 TANK
 TRAF family member-associated NFKB activator
 140
 0.97
chr11_62444789_62444940 0.28 UBXN1
 UBX domain protein 1
 591
 0.42
chr11_36641126_36641415 0.28 RAG2
 recombination activating gene 2
 21484
 0.19
chr1_29255082_29255406 0.28 EPB41
 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
 14153
 0.18
chr17_27467519_27468040 0.28 RP11-321A17.4
278
 0.55
chr9_123606315_123606466 0.28 PSMD5-AS1
 PSMD5 antisense RNA 1 (head to head)
 601
 0.6
chr5_75699014_75699893 0.28 IQGAP2
 IQ motif containing GTPase activating protein 2
 304
 0.94
chr11_104951685_104951836 0.28 CASP1
 caspase 1, apoptosis-related cysteine peptidase
 20398
 0.15
chr14_22565525_22565676 0.27 ENSG00000238634
 .
 45287
 0.18
chr18_26676772_26676923 0.27 ENSG00000265730
 .
 1204
 0.6
chr17_43486558_43486834 0.27 ARHGAP27
 Rho GTPase activating protein 27
 1056
 0.39
chr15_81591495_81592151 0.27 IL16
 interleukin 16
 66
 0.98
chr19_42391098_42391303 0.27 ARHGEF1
 Rho guanine nucleotide exchange factor (GEF) 1
 2685
 0.17
chr1_27945148_27945299 0.27 FGR
 feline Gardner-Rasheed sarcoma viral oncogene homolog
 5350
 0.15
chr4_17205389_17205540 0.27 ENSG00000206780
 .
 117041
 0.07
chr2_175462178_175462605 0.27 WIPF1
 WAS/WASL interacting protein family, member 1
 102
 0.97
chr8_83009707_83009858 0.27 SNX16
 sorting nexin 16
 254681
 0.02
chr8_125617266_125617519 0.27 RP11-532M24.1
25520
 0.16
chr5_14268280_14268580 0.27 TRIO
 trio Rho guanine nucleotide exchange factor
 22656
 0.28
chr16_3452838_3453133 0.27 ZNF174
 zinc finger protein 174
 1011
 0.36
chr9_130855530_130855681 0.27 RP11-379C10.4
1131
 0.27
chr7_94039789_94039940 0.27 COL1A2
 collagen, type I, alpha 2
 15991
 0.25
chr3_32995541_32995692 0.27 CCR4
 chemokine (C-C motif) receptor 4
 2550
 0.37
chr17_37931079_37931230 0.27 IKZF3
 IKAROS family zinc finger 3 (Aiolos)
 3324
 0.18
chr16_1730441_1730592 0.26 HN1L
 hematological and neurological expressed 1-like
 178
 0.89
chr20_62258641_62259758 0.26 CTD-3184A7.4
596
 0.45
chrX_19815653_19816006 0.26 SH3KBP1
 SH3-domain kinase binding protein 1
 2040
 0.46
chr6_109262468_109262619 0.26 ARMC2-AS1
 ARMC2 antisense RNA 1
 17237
 0.2
chr3_115596546_115596697 0.26 ENSG00000243359
 .
 39906
 0.22
chr4_154439708_154439859 0.26 KIAA0922
 KIAA0922
 37265
 0.19
chr2_122660445_122660607 0.26 TSN
 translin
 146779
 0.04
chr2_182322868_182323440 0.26 ITGA4
 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
 999
 0.69
chrX_78201853_78202096 0.26 P2RY10
 purinergic receptor P2Y, G-protein coupled, 10
 1056
 0.69
chr17_56416209_56416360 0.26 BZRAP1-AS1
 BZRAP1 antisense RNA 1
 1565
 0.24
chr17_74235344_74235495 0.26 RNF157
 ring finger protein 157
 963
 0.47
chr3_187005158_187005309 0.26 MASP1
 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
 4252
 0.27
chr13_52397484_52397635 0.26 RP11-327P2.5
19126
 0.17
chr1_226922484_226922931 0.26 ITPKB
 inositol-trisphosphate 3-kinase B
 2452
 0.34
chr4_41122983_41123211 0.26 ENSG00000207198
 .
 7138
 0.23
chr17_42072137_42072373 0.26 PYY
 peptide YY
 9582
 0.1
chr2_143905734_143905885 0.25 ARHGAP15
 Rho GTPase activating protein 15
 18926
 0.23
chr4_7878163_7878536 0.25 AFAP1
 actin filament associated protein 1
 4309
 0.28
chr1_155900220_155900371 0.25 KIAA0907
 KIAA0907
 3869
 0.1
chr10_92434851_92435027 0.25 HTR7
 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
 182516
 0.03
chr6_26358532_26358683 0.25 ENSG00000252399
 .
 5343
 0.1
chr3_56833713_56834040 0.25 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 2101
 0.44
chr1_9777067_9777879 0.25 PIK3CD
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
 654
 0.69
chr15_53096656_53097309 0.25 ONECUT1
 one cut homeobox 1
 14773
 0.27
chr2_231200345_231200592 0.25 SP140L
 SP140 nuclear body protein-like
 6317
 0.26
chr1_167484289_167484555 0.25 CD247
 CD247 molecule
 3353
 0.26
chr9_139437724_139437875 0.25 RP11-413M3.4
466
 0.63
chr6_37017654_37018643 0.25 COX6A1P2
 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
 5541
 0.22

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.6 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.1 0.3 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.2 GO:0003032 detection of oxygen(GO:0003032)
0.1 0.3 GO:0002664 T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0 0.1 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.3 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0072216 positive regulation of metanephros development(GO:0072216)
0.0 0.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.2 GO:0002921 negative regulation of humoral immune response(GO:0002921)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.2 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.2 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.2 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.6 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.0 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.1 GO:0014889 muscle atrophy(GO:0014889)
0.0 0.1 GO:0061028 establishment of endothelial barrier(GO:0061028)
0.0 0.1 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.2 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.2 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.1 GO:0048289 isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.2 GO:0002327 immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.1 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 0.1 GO:0039656 modulation by virus of host gene expression(GO:0039656)
0.0 0.2 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0 0.1 GO:0015825 L-serine transport(GO:0015825)
0.0 0.1 GO:0060976 coronary vasculature development(GO:0060976)
0.0 0.1 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:0034653 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.0 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.1 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.2 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.2 GO:0071636 positive regulation of transforming growth factor beta production(GO:0071636)
0.0 0.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.1 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.2 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.0 0.1 GO:0046666 retinal cell programmed cell death(GO:0046666)
0.0 0.1 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.0 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0 0.1 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.2 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.1 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.0 GO:0002507 tolerance induction(GO:0002507)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.2 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.1 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.1 GO:0090382 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0 0.1 GO:0045901 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.0 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.2 GO:0001782 B cell homeostasis(GO:0001782)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.0 GO:0046100 hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0 0.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0045354 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0 0.1 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.0 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.1 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.0 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.0 0.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.0 GO:0046931 pore complex assembly(GO:0046931)
0.0 0.1 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.0 0.0 GO:0060430 lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0072217 negative regulation of metanephros development(GO:0072217)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.0 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.2 GO:0042255 ribosome assembly(GO:0042255)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.0 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.0 GO:0006565 L-serine catabolic process(GO:0006565)
0.0 0.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:2001259 activation of store-operated calcium channel activity(GO:0032237) positive regulation of calcium ion transmembrane transporter activity(GO:1901021) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341) positive regulation of cation channel activity(GO:2001259)
0.0 0.0 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.0 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.0 GO:0051136 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.0 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.0 GO:0048541 regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645) Peyer's patch development(GO:0048541)
0.0 0.0 GO:0046137 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.2 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.1 GO:0046719 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.0 GO:0072239 metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0 0.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.1 GO:0032733 positive regulation of interleukin-10 production(GO:0032733)
0.0 0.0 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 0.0 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.0 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.0 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.1 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.2 GO:0042308 negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein localization to nucleus(GO:1900181) negative regulation of protein import(GO:1904590)
0.0 0.0 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.0 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.0 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0009158 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.0 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0 0.1 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.0 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.0 0.1 GO:0045061 thymic T cell selection(GO:0045061)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390)
0.0 0.0 GO:1901798 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.0 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.0 GO:0071875 adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 0.0 GO:0033084 regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.0 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.1 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516) regulation of signal transduction by p53 class mediator(GO:1901796)
0.0 0.0 GO:0042940 D-amino acid transport(GO:0042940) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.0 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.0 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.0 GO:0060120 auditory receptor cell fate commitment(GO:0009912) auditory receptor cell fate determination(GO:0042668) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.0 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.0 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.5 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.0 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.3 GO:0019079 viral genome replication(GO:0019079)
0.0 0.5 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.3 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.0 0.1 GO:0050812 acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0 0.0 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.0 GO:0019049 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.0 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.0 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.0 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0015840 urea transport(GO:0015840)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0032156 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.2 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.6 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.6 GO:0030175 filopodium(GO:0030175)
0.0 0.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.0 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.0 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.2 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.4 GO:0005884 actin filament(GO:0005884)
0.0 0.0 GO:0031904 endosome lumen(GO:0031904)
0.0 0.1 GO:0016580 Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0 0.0 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.6 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0005678 obsolete chromatin assembly complex(GO:0005678)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.1 GO:0019958 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.1 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.5 GO:0005522 profilin binding(GO:0005522)
0.1 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.2 GO:0042608 T cell receptor binding(GO:0042608)
0.1 0.2 GO:0031628 opioid receptor binding(GO:0031628)
0.1 0.2 GO:0016151 nickel cation binding(GO:0016151)
0.1 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.0 GO:0070052 collagen V binding(GO:0070052)
0.0 0.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.2 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.4 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.6 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.2 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0003701 obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.2 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.0 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.0 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.1 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.0 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 0.3 GO:0043022 ribosome binding(GO:0043022)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.0 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.0 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.2 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.0 GO:0051380 norepinephrine binding(GO:0051380)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.0 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.0 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.0 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.0 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.0 0.5 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0032407 MutSalpha complex binding(GO:0032407)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.0 GO:1990939 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.1 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.0 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.0 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0051117 ATPase binding(GO:0051117)
0.0 0.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.3 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.5 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.8 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.0 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.1 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.8 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.0 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.0 REACTOME OPSINS Genes involved in Opsins
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.1 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.5 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.1 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.1 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.0 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 0.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.0 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.1 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway