Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SIX4

Z-value: 0.52

Motif logo

Transcription factors associated with SIX4

Gene Symbol	Gene ID	Gene Info
SIX4 Ensembl NCBI GeneCards UniProt	ENSG00000100625.8	SIX4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SIX4	chr14_61190612_61190839	127	0.967784	-0.35	3.6e-01	Click!
SIX4	chr14_61188583_61188797	2162	0.334416	-0.30	4.4e-01	Click!
SIX4	chr14_61188418_61188569	2359	0.316607	-0.25	5.2e-01	Click!
SIX4	chr14_61190877_61191072	92	0.973959	-0.24	5.4e-01	Click!
SIX4	chr14_61188910_61189596	1599	0.413092	-0.15	6.9e-01	Click!

Activity of the SIX4 motif across conditions

Conditions sorted by the z-value of the SIX4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_126308274_126308480	0.16	FAM53B-AS1	FAM53B antisense RNA 1	83817	0.08
chr16_83620596_83620747	0.12	ENSG00000263785	.	78720	0.09
chr12_32050718_32050938	0.12	ENSG00000252584	.	17813	0.2
chr2_64894623_64894774	0.12	SERTAD2	SERTA domain containing 2	13651	0.23
chr2_172734713_172734864	0.11	SLC25A12	solute carrier family 25 (aspartate/glutamate carrier), member 12	15945	0.18
chr22_19950191_19950342	0.11	COMT	catechol-O-methyltransferase	196	0.86
chr8_53063329_53063558	0.11	RP11-26M5.3		63	0.98
chr17_40937029_40937180	0.11	WNK4	WNK lysine deficient protein kinase 4	4408	0.09
chr11_35949210_35949523	0.11	RP11-698N11.2		9077	0.19
chr20_50664659_50664866	0.11	ZFP64	ZFP64 zinc finger protein	50243	0.17
chr11_100555302_100555453	0.11	ARHGAP42	Rho GTPase activating protein 42	3007	0.26
chr4_165040749_165040900	0.11	MARCH1	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	264317	0.02
chr12_80079262_80079413	0.10	PAWR	PRKC, apoptosis, WT1, regulator	4523	0.3
chr12_107631394_107631672	0.10	BTBD11	BTB (POZ) domain containing 11	80657	0.1
chr7_107587877_107588028	0.10	CTB-13F3.1		5391	0.21
chr7_73682843_73682994	0.10	ENSG00000252538	.	9972	0.16
chr7_964241_964392	0.10	ADAP1	ArfGAP with dual PH domains 1	2536	0.22
chr2_196434123_196434274	0.10	SLC39A10	solute carrier family 39 (zinc transporter), member 10	6503	0.28
chr12_123368397_123368548	0.10	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)	6234	0.18
chr22_28063217_28063368	0.10	RP11-375H17.1		49176	0.18
chr6_46702576_46703631	0.09	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	24	0.97
chr18_25667459_25667610	0.09	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	9659	0.32
chr1_957490_957641	0.09	AGRN	agrin	2062	0.15
chr20_49378517_49378668	0.09	PARD6B	par-6 family cell polarity regulator beta	30390	0.14
chr3_5857555_5857706	0.09	ENSG00000241227	.	562722	0.0
chr21_33744937_33745088	0.09	ENSG00000200792	.	4619	0.15
chr2_161094906_161095057	0.09	ITGB6	integrin, beta 6	38166	0.21
chr13_101262503_101262654	0.09	GGACT	gamma-glutamylamine cyclotransferase	20796	0.19
chr2_75043587_75043738	0.09	HK2	hexokinase 2	17446	0.23
chr2_38265076_38265999	0.08	RMDN2-AS1	RMDN2 antisense RNA 1	2053	0.33
chr10_28378559_28378902	0.08	ARMC4	armadillo repeat containing 4	90753	0.09
chr6_155438873_155439024	0.08	TIAM2	T-cell lymphoma invasion and metastasis 2	4102	0.33
chr8_104384027_104384290	0.08	CTHRC1	collagen triple helix repeat containing 1	380	0.83
chr14_75689238_75689389	0.08	ENSG00000252013	.	20441	0.14
chr14_22749370_22749521	0.08	ENSG00000238634	.	138558	0.04
chr1_204333064_204333215	0.08	PLEKHA6	pleckstrin homology domain containing, family A member 6	4095	0.21
chr11_3923942_3924093	0.08	STIM1	stromal interaction molecule 1	676	0.62
chr16_13520212_13520363	0.08	AC003009.1		93847	0.09
chr17_78912361_78912527	0.08	CTD-2561B21.4		3389	0.17
chr20_31888809_31889213	0.08	BPIFB1	BPI fold containing family B, member 1	18070	0.15
chr16_66008915_66009066	0.08	ENSG00000201999	.	326722	0.01
chr20_50104056_50104339	0.08	ENSG00000266761	.	34683	0.19
chr19_2089521_2089711	0.08	MOB3A	MOB kinase activator 3A	559	0.63
chr1_245316415_245317636	0.08	KIF26B	kinesin family member 26B	1262	0.47
chr16_23084021_23084263	0.08	USP31	ubiquitin specific peptidase 31	273	0.95
chr6_168473471_168473622	0.08	FRMD1	FERM domain containing 1	3000	0.33
chr22_25346267_25346418	0.08	KIAA1671	KIAA1671	2355	0.29
chr11_133459496_133459647	0.08	OPCML	opioid binding protein/cell adhesion molecule-like	57157	0.15
chr1_214499564_214499715	0.07	SMYD2	SET and MYND domain containing 2	4681	0.29
chr1_109597558_109597709	0.07	WDR47	WD repeat domain 47	12783	0.12
chr11_117881316_117881467	0.07	IL10RA	interleukin 10 receptor, alpha	24282	0.15
chr1_43411974_43412125	0.07	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	12451	0.18
chr12_66122461_66123138	0.07	HMGA2	high mobility group AT-hook 2	95112	0.08
chr3_165828020_165828171	0.07	BCHE	butyrylcholinesterase	272835	0.02
chr15_48937037_48938293	0.07	FBN1	fibrillin 1	253	0.95
chr7_118512519_118512670	0.07	ENSG00000222226	.	410041	0.01
chr3_195713973_195714124	0.07	SDHAP1	succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1	3081	0.23
chr1_9048089_9048240	0.07	ENSG00000265141	.	8231	0.17
chr2_238358341_238358492	0.07	AC112721.1	Uncharacterized protein	24497	0.16
chr7_140677362_140677513	0.07	MRPS33	mitochondrial ribosomal protein S33	36792	0.15
chr2_70750715_70751050	0.07	TGFA	transforming growth factor, alpha	29740	0.17
chr3_184037306_184037783	0.07	EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	1	0.95
chr20_1602572_1602723	0.07	RP4-576H24.4	Uncharacterized protein	1992	0.21
chr20_11098246_11098397	0.07	C20orf187	chromosome 20 open reading frame 187	89510	0.1
chr1_95388573_95389173	0.07	CNN3	calponin 3, acidic	2464	0.27
chr3_157924014_157924165	0.07	RSRC1	arginine/serine-rich coiled-coil 1	3228	0.38
chr4_3391445_3391596	0.07	RGS12	regulator of G-protein signaling 12	3459	0.27
chr17_16177405_16177556	0.07	ENSG00000221355	.	7848	0.18
chr6_53458265_53458416	0.07	GCLC	glutamate-cysteine ligase, catalytic subunit	23428	0.17
chr2_27890028_27890179	0.07	SUPT7L	suppressor of Ty 7 (S. cerevisiae)-like	3427	0.14
chr2_216288358_216288696	0.07	FN1	fibronectin 1	12263	0.21
chrX_111124795_111124946	0.07	TRPC5OS	TRPC5 opposite strand	255	0.96
chr20_52324568_52324793	0.07	ENSG00000238468	.	39383	0.19
chr3_134036563_134036714	0.07	AMOTL2	angiomotin like 2	54116	0.13
chr7_73304367_73304518	0.07	WBSCR28	Williams-Beuren syndrome chromosome region 28	28953	0.15
chr15_71606160_71606311	0.07	RP11-592N21.2		28428	0.23
chr20_4142074_4142225	0.07	SMOX	spermine oxidase	10208	0.21
chr3_99791321_99791472	0.07	FILIP1L	filamin A interacting protein 1-like	41961	0.15
chr1_77942138_77942289	0.07	AK5	adenylate kinase 5	55579	0.12
chr22_38199332_38199483	0.07	H1F0	H1 histone family, member 0	1707	0.2
chr9_133838398_133838632	0.07	FIBCD1	fibrinogen C domain containing 1	23988	0.14
chr17_19769997_19771171	0.07	ULK2	unc-51 like autophagy activating kinase 2	646	0.74
chr6_159674242_159674415	0.07	FNDC1-IT1	FNDC1 intronic transcript 1 (non-protein coding)	12510	0.24
chr2_136577729_136578391	0.07	AC011893.3		299	0.89
chr1_180062348_180062499	0.07	CEP350	centrosomal protein 350kDa	426	0.88
chr1_244264308_244264663	0.07	ENSG00000244066	.	2749	0.32
chr7_107045766_107045917	0.07	GPR22	G protein-coupled receptor 22	64664	0.11
chr5_58858854_58859005	0.07	PDE4D	phosphodiesterase 4D, cAMP-specific	23290	0.28
chr22_30658388_30658630	0.07	OSM	oncostatin M	3298	0.13
chr4_129732983_129734245	0.07	JADE1	jade family PHD finger 1	615	0.83
chr16_23515749_23516009	0.07	GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	5831	0.15
chr7_55620313_55620510	0.07	VOPP1	vesicular, overexpressed in cancer, prosurvival protein 1	134	0.97
chr11_68049808_68050049	0.06	C11orf24	chromosome 11 open reading frame 24	10471	0.2
chr2_79951275_79951426	0.06	ENSG00000263566	.	70046	0.1
chr16_53086342_53086851	0.06	RP11-467J12.4		189	0.95
chr13_67597561_67597712	0.06	PCDH9-AS4	PCDH9 antisense RNA 4	32618	0.21
chr4_154412529_154412680	0.06	KIAA0922	KIAA0922	25103	0.22
chr3_49137947_49138098	0.06	QARS	glutaminyl-tRNA synthetase	994	0.34
chr9_136009638_136009789	0.06	RALGDS	ral guanine nucleotide dissociation stimulator	3209	0.19
chr2_6221801_6221952	0.06	DKFZP761K2322	HCG1990367; Putative uncharacterized protein DKFZp761K2322; Putative uncharacterized protein FLJ30594; Uncharacterized protein; cDNA FLJ30594 fis, clone BRAWH2008903	110164	0.08
chr16_9204517_9204668	0.06	RP11-473I1.10		3494	0.19
chr5_73929379_73929530	0.06	HEXB	hexosaminidase B (beta polypeptide)	6394	0.22
chr20_57235059_57235243	0.06	STX16	syntaxin 16	7425	0.17
chr2_50719361_50719512	0.06	NRXN1	neurexin 1	3778	0.38
chr7_28530451_28530602	0.06	CREB5	cAMP responsive element binding protein 5	222	0.97
chr5_17400004_17400276	0.06	ENSG00000201715	.	54415	0.16
chr14_70117061_70117212	0.06	KIAA0247	KIAA0247	38823	0.17
chr2_198077334_198077485	0.06	ANKRD44	ankyrin repeat domain 44	14647	0.2
chr2_28601499_28601815	0.06	FOSL2	FOS-like antigen 2	14012	0.17
chr22_29601932_29602692	0.06	EMID1	EMI domain containing 1	400	0.8
chr16_28158064_28158215	0.06	XPO6	exportin 6	23083	0.16
chr12_122460681_122461523	0.06	BCL7A	B-cell CLL/lymphoma 7A	1310	0.49
chr18_45463703_45463854	0.06	SMAD2	SMAD family member 2	6263	0.28
chr1_210465594_210466382	0.06	HHAT	hedgehog acyltransferase	35608	0.17
chr2_174436276_174436427	0.06	CDCA7	cell division cycle associated 7	216751	0.02
chr2_235397051_235397202	0.06	ARL4C	ADP-ribosylation factor-like 4C	8118	0.33
chr10_11192421_11192572	0.06	CELF2	CUGBP, Elav-like family member 2	14497	0.2
chr4_185827450_185827601	0.06	ENSG00000263458	.	32069	0.17
chr15_84033783_84034563	0.06	BNC1	basonuclin 1	80707	0.09
chr12_27742378_27742529	0.06	PPFIBP1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	9828	0.23
chr3_46994537_46994688	0.06	CCDC12	coiled-coil domain containing 12	23658	0.14
chr8_48515171_48515322	0.06	SPIDR	scaffolding protein involved in DNA repair	56980	0.12
chr21_44036406_44036646	0.06	AP001626.2		34828	0.13
chr21_30720865_30721016	0.06	BACH1-IT1	BACH1 intronic transcript 1 (non-protein coding)	3015	0.22
chrX_19716745_19716896	0.06	SH3KBP1	SH3-domain kinase binding protein 1	27704	0.25
chr22_45642723_45642874	0.06	KIAA0930	KIAA0930	6148	0.19
chr12_65032414_65032565	0.06	RP11-338E21.2		10365	0.12
chr15_68574240_68574639	0.06	FEM1B	fem-1 homolog b (C. elegans)	2142	0.31
chr5_6349990_6350141	0.06	MED10	mediator complex subunit 10	28642	0.24
chr16_21518478_21518933	0.06	ENSG00000265462	.	1249	0.41
chr3_31719857_31720008	0.06	OSBPL10-AS1	OSBPL10 antisense RNA 1	25618	0.25
chr7_44922298_44922675	0.06	ENSG00000264326	.	1087	0.34
chr8_128911768_128911919	0.06	TMEM75	transmembrane protein 75	48748	0.14
chrX_144503620_144503771	0.06	SPANXN1	SPANX family, member N1	175347	0.03
chr4_148675376_148675527	0.06	ENSG00000252951	.	8883	0.18
chr4_7972052_7972961	0.06	AFAP1	actin filament associated protein 1	30853	0.14
chr15_99386539_99386690	0.06	IGF1R	insulin-like growth factor 1 receptor	46956	0.14
chr10_131754567_131754718	0.06	EBF3	early B-cell factor 3	7463	0.31
chr18_47090550_47090839	0.06	LIPG	lipase, endothelial	1979	0.29
chr11_79833397_79833684	0.06	ENSG00000200146	.	405464	0.01
chr11_124940847_124941136	0.06	SLC37A2	solute carrier family 37 (glucose-6-phosphate transporter), member 2	7759	0.19
chr3_151744346_151744509	0.06	RP11-454C18.2		98464	0.08
chr12_22781335_22781486	0.06	ETNK1	ethanolamine kinase 1	3119	0.28
chr3_179191370_179191536	0.06	GNB4	guanine nucleotide binding protein (G protein), beta polypeptide 4	22075	0.17
chr7_96646152_96646303	0.06	DLX6-AS1	DLX6 antisense RNA 1	2850	0.21
chr15_68958574_68958725	0.06	CORO2B	coronin, actin binding protein, 2B	34322	0.21
chr12_95609361_95609804	0.06	FGD6	FYVE, RhoGEF and PH domain containing 6	1573	0.32
chr17_41608232_41608498	0.05	ETV4	ets variant 4	563	0.68
chr8_134261990_134262245	0.05	WISP1-OT1	WISP1 overlapping transcript 1 (non-protein coding)	20818	0.21
chr10_48600586_48600737	0.05	GDF10	growth differentiation factor 10	161685	0.03
chr6_155599532_155599683	0.05	CLDN20	claudin 20	14460	0.19
chr18_54741654_54741805	0.05	WDR7-OT1	WDR7 overlapping transcript 1 (non-protein coding)	46666	0.16
chr4_15685369_15685921	0.05	FAM200B	family with sequence similarity 200, member B	2216	0.26
chr1_234792015_234792239	0.05	IRF2BP2	interferon regulatory factor 2 binding protein 2	46856	0.14
chr3_190038156_190038307	0.05	CLDN1	claudin 1	2033	0.41
chr17_39739860_39740150	0.05	KRT14	keratin 14	3168	0.13
chr12_124386990_124387141	0.05	DNAH10	dynein, axonemal, heavy chain 10	5795	0.12
chr15_74217167_74217391	0.05	LOXL1-AS1	LOXL1 antisense RNA 1	1360	0.3
chr12_94634224_94634375	0.05	PLXNC1	plexin C1	13995	0.18
chr5_141977695_141977846	0.05	AC005592.2		16357	0.19
chr6_21264625_21264776	0.05	ENSG00000252046	.	270901	0.02
chr6_154735371_154735522	0.05	CNKSR3	CNKSR family member 3	16183	0.26
chr18_71356092_71356243	0.05	ENSG00000241866	.	56003	0.18
chr7_80412610_80412761	0.05	CD36	CD36 molecule (thrombospondin receptor)	109993	0.07
chr9_90356869_90357020	0.05	ENSG00000222408	.	2964	0.25
chr15_84363051_84363202	0.05	ENSG00000212374	.	23053	0.2
chr12_16501163_16501421	0.05	MGST1	microsomal glutathione S-transferase 1	561	0.83
chr2_16616720_16616871	0.05	AC104623.2		87649	0.1
chr4_186227680_186227831	0.05	RP11-714G18.1		64124	0.08
chr14_22538566_22539116	0.05	ENSG00000238634	.	72046	0.12
chr17_17641829_17642128	0.05	RAI1-AS1	RAI1 antisense RNA 1	32157	0.12
chr2_173258453_173258604	0.05	ITGA6	integrin, alpha 6	33554	0.16
chr4_77932231_77932404	0.05	SEPT11	septin 11	9368	0.24
chr4_29417750_29417901	0.05	ENSG00000252303	.	94432	0.1
chr16_2656430_2656581	0.05	AC141586.5		3030	0.11
chr20_1518089_1518396	0.05	ENSG00000252103	.	8437	0.14
chr4_148518499_148518650	0.05	RP11-425A23.1		19822	0.19
chrX_111125134_111125285	0.05	TRPC5OS	TRPC5 opposite strand	84	0.98
chr11_61739742_61739933	0.05	AP003733.1	Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801	4384	0.15
chr6_138249034_138249358	0.05	RP11-356I2.4		59826	0.13
chr10_70847938_70848765	0.05	SRGN	serglycin	477	0.82
chr16_80793490_80793641	0.05	CTD-2055G21.1		23308	0.19
chr9_86451900_86452137	0.05	RP11-575L7.2		51	0.97
chr20_33871790_33873092	0.05	EIF6	eukaryotic translation initiation factor 6	77	0.88
chr11_108408309_108408460	0.05	EXPH5	exophilin 5	550	0.8
chr3_171594335_171594540	0.05	TMEM212-IT1	TMEM212 intronic transcript 1 (non-protein coding)	17789	0.2
chr11_85894364_85894515	0.05	ENSG00000200877	.	30170	0.18
chr6_34632212_34632529	0.05	C6orf106	chromosome 6 open reading frame 106	7363	0.14
chr21_40378453_40378604	0.05	ENSG00000272015	.	111819	0.06
chr9_14170879_14171030	0.05	NFIB	nuclear factor I/B	9837	0.32
chr6_138070872_138071097	0.05	ENSG00000216097	.	32899	0.17
chr7_130132004_130132893	0.05	MEST	mesoderm specific transcript	135	0.93
chr17_30114926_30115210	0.05	COPRS	coordinator of PRMT5, differentiation stimulator	70882	0.09
chr16_10934760_10934911	0.05	TVP23A	trans-golgi network vesicle protein 23 homolog A (S. cerevisiae)	22193	0.15
chr1_2985287_2985858	0.05	PRDM16	PR domain containing 16	160	0.85
chr5_137348056_137348207	0.05	RP11-325L7.1		20332	0.13
chr2_173145916_173146187	0.05	ENSG00000238572	.	125203	0.05
chr7_28747986_28748200	0.05	CREB5	cAMP responsive element binding protein 5	22495	0.28
chr15_49098614_49098784	0.05	CEP152	centrosomal protein 152kDa	4092	0.19
chr9_20377607_20377758	0.05	MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	4785	0.23

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.1	GO:0071692	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	GO:0002125	maternal aggressive behavior(GO:0002125)
0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	GO:0008295	spermidine biosynthetic process(GO:0008295)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.0	GO:0042629	mast cell granule(GO:0042629)
0.1	GO:0001527	microfibril(GO:0001527)
0.0	GO:0032059	bleb(GO:0032059)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)