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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for SIX6

Z-value: 1.58

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Transcription factors associated with SIX6

Gene Symbol	Gene ID	Gene Info
SIX6 Ensembl NCBI GeneCards UniProt	ENSG00000184302.6	SIX homeobox 6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr14_60978223_60978374	SIX6	2629	0.237859	-0.59	9.5e-02	Click!
chr14_60978046_60978197	SIX6	2452	0.250476	-0.09	8.1e-01	Click!

Activity of the SIX6 motif across conditions

Conditions sorted by the z-value of the SIX6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_148189087_148189390	1.94	ADRB2	adrenoceptor beta 2, surface	16918	0.25
chr11_118210860_118211247	1.66	CD3D	CD3d molecule, delta (CD3-TCR complex)	599	0.61
chr16_6001852_6002003	1.37	RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	67168	0.13
chr6_106547367_106547905	1.29	RP1-134E15.3		379	0.74
chrX_106956955_106957175	1.14	TSC22D3	TSC22 domain family, member 3	2566	0.34
chr5_118670002_118670187	1.11	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	1224	0.51
chr1_169679248_169679951	1.11	SELL	selectin L	1240	0.48
chr2_204572665_204572956	1.06	CD28	CD28 molecule	1394	0.52
chr1_29242251_29242585	0.99	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	1327	0.43
chr3_151963057_151963208	0.96	MBNL1	muscleblind-like splicing regulator 1	22697	0.21
chr14_22960619_22960887	0.91	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	4582	0.12
chr1_32729486_32729739	0.88	LCK	lymphocyte-specific protein tyrosine kinase	10102	0.09
chr3_151936530_151936714	0.83	MBNL1	muscleblind-like splicing regulator 1	49207	0.15
chr13_99909901_99910052	0.82	GPR18	G protein-coupled receptor 18	652	0.73
chr1_40847512_40847991	0.81	SMAP2	small ArfGAP2	7431	0.18
chr9_123687593_123687825	0.80	TRAF1	TNF receptor-associated factor 1	3338	0.27
chr5_159897528_159897679	0.79	ENSG00000265237	.	3806	0.2
chr1_112016807_112017159	0.79	C1orf162	chromosome 1 open reading frame 162	492	0.65
chr12_9912315_9912520	0.78	CD69	CD69 molecule	1080	0.47
chr8_38215592_38215743	0.75	RP11-513D5.2		22168	0.11
chr17_33864237_33864745	0.74	SLFN12L	schlafen family member 12-like	389	0.76
chr19_2084034_2084229	0.73	MOB3A	MOB kinase activator 3A	1260	0.31
chr8_42567726_42567877	0.73	RP11-412B14.1		9288	0.19
chr1_198610920_198611071	0.72	PTPRC	protein tyrosine phosphatase, receptor type, C	2703	0.34
chr14_91868738_91869034	0.71	CCDC88C	coiled-coil domain containing 88C	14804	0.23
chr12_56324614_56324841	0.71	DGKA	diacylglycerol kinase, alpha 80kDa	29	0.94
chr13_31309966_31310295	0.70	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	485	0.88
chr19_7410752_7411085	0.70	CTB-133G6.1		2930	0.22
chr1_229275455_229275606	0.69	RP5-1061H20.5		87779	0.08
chr11_118175872_118176125	0.68	CD3E	CD3e molecule, epsilon (CD3-TCR complex)	384	0.79
chr12_9822873_9823085	0.66	CLEC2D	C-type lectin domain family 2, member D	630	0.62
chrX_17672911_17673062	0.66	NHS	Nance-Horan syndrome (congenital cataracts and dental anomalies)	19573	0.24
chr16_75836248_75836399	0.66	ENSG00000199299	.	58732	0.12
chr8_8727017_8727210	0.66	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	24042	0.18
chr2_201986320_201986471	0.66	CFLAR	CASP8 and FADD-like apoptosis regulator	805	0.53
chr17_29648360_29648569	0.66	EVI2A	ecotropic viral integration site 2A	303	0.84
chr13_100308687_100308874	0.66	ENSG00000263615	.	13467	0.18
chr22_38788888_38789039	0.65	RP1-5O6.4		4101	0.15
chr11_65868544_65868961	0.65	PACS1	phosphofurin acidic cluster sorting protein 1	518	0.66
chr5_156610422_156610951	0.65	ITK	IL2-inducible T-cell kinase	2849	0.18
chr2_175496475_175496626	0.65	WIPF1	WAS/WASL interacting protein family, member 1	2757	0.3
chr12_49312255_49312671	0.65	FKBP11	FK506 binding protein 11, 19 kDa	6287	0.08
chr3_56834055_56834206	0.64	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	1847	0.48
chr2_68963054_68963510	0.64	ARHGAP25	Rho GTPase activating protein 25	1268	0.56
chr4_154390309_154390666	0.64	KIAA0922	KIAA0922	2986	0.33
chr18_65562637_65562788	0.63	DSEL	dermatan sulfate epimerase-like	378495	0.01
chrX_97323503_97323654	0.63	DIAPH2-AS1	DIAPH2 antisense RNA 1	425990	0.01
chr13_41556565_41556847	0.62	ELF1	E74-like factor 1 (ets domain transcription factor)	288	0.92
chr1_198652510_198652661	0.62	RP11-553K8.5		16395	0.24
chr3_112215334_112215665	0.62	BTLA	B and T lymphocyte associated	2706	0.33
chr15_38849659_38849810	0.62	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	2549	0.27
chr6_108145054_108145346	0.62	SCML4	sex comb on midleg-like 4 (Drosophila)	316	0.93
chr12_79322634_79322785	0.62	SYT1	synaptotagmin I	35106	0.23
chr9_106345468_106345619	0.61	ENSG00000253031	.	106316	0.08
chr12_9912992_9913534	0.61	CD69	CD69 molecule	234	0.92
chr1_100820619_100820952	0.61	CDC14A	cell division cycle 14A	2280	0.29
chrX_12991784_12992037	0.61	TMSB4X	thymosin beta 4, X-linked	1317	0.51
chr6_31543928_31544133	0.61	TNF	tumor necrosis factor	686	0.34
chr11_3880339_3880818	0.60	STIM1	stromal interaction molecule 1	3166	0.13
chr14_23010597_23010748	0.60	TRAJ15	T cell receptor alpha joining 15	12092	0.1
chr17_38262046_38262197	0.59	NR1D1	nuclear receptor subfamily 1, group D, member 1	5143	0.13
chr7_38387955_38388106	0.59	AMPH	amphiphysin	114683	0.07
chrX_78620075_78620267	0.59	ITM2A	integral membrane protein 2A	2685	0.44
chr11_128393277_128393428	0.58	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	1147	0.52
chr3_69248462_69249135	0.58	FRMD4B	FERM domain containing 4B	377	0.9
chr15_67374785_67374936	0.58	SMAD3	SMAD family member 3	16060	0.25
chr15_64926266_64926417	0.58	ENSG00000207223	.	18746	0.14
chr7_38401525_38401676	0.58	AMPH	amphiphysin	101113	0.08
chr14_49374188_49374339	0.58	ENSG00000251824	.	36454	0.24
chr17_33861823_33861994	0.58	SLFN12L	schlafen family member 12-like	2972	0.15
chr3_151921407_151921835	0.56	MBNL1	muscleblind-like splicing regulator 1	64208	0.12
chr1_192842951_192843102	0.56	ENSG00000223075	.	2089	0.41
chr6_92032285_92032436	0.56	ENSG00000263734	.	199018	0.03
chr12_42491237_42491388	0.55	ENSG00000222884	.	17749	0.22
chr14_22980147_22980432	0.55	TRAJ15	T cell receptor alpha joining 15	18291	0.09
chr13_46752366_46752713	0.55	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	3920	0.19
chr8_134084504_134084857	0.55	SLA	Src-like-adaptor	12077	0.24
chr1_117298023_117298174	0.55	CD2	CD2 molecule	1009	0.59
chr17_77807104_77807360	0.55	CBX4	chromobox homolog 4	4448	0.17
chr14_22572085_22572236	0.55	ENSG00000238634	.	38727	0.2
chr2_175459196_175459684	0.54	WIPF1	WAS/WASL interacting protein family, member 1	3053	0.24
chr2_170486384_170486535	0.54	PPIG	peptidylprolyl isomerase G (cyclophilin G)	45302	0.11
chr12_96597744_96597895	0.54	ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	9427	0.2
chrX_45667430_45667744	0.53	ENSG00000207725	.	61057	0.13
chr2_87782164_87782461	0.52	RP11-1399P15.1		4759	0.34
chr8_124829666_124829817	0.52	FER1L6	fer-1-like 6 (C. elegans)	34486	0.17
chr14_90865510_90865807	0.52	CALM1	calmodulin 1 (phosphorylase kinase, delta)	1052	0.5
chr1_22402292_22402667	0.52	CDC42-IT1	CDC42 intronic transcript 1 (non-protein coding)	16789	0.13
chrX_78621479_78621720	0.51	ITM2A	integral membrane protein 2A	1257	0.64
chr5_89941833_89941984	0.51	GPR98	G protein-coupled receptor 98	17532	0.27
chr12_10020930_10021432	0.51	CLEC2B	C-type lectin domain family 2, member B	1554	0.25
chr9_4664226_4664377	0.50	PPAPDC2	phosphatidic acid phosphatase type 2 domain containing 2	2003	0.26
chr17_61772565_61772716	0.50	LIMD2	LIM domain containing 2	3882	0.18
chr6_149801297_149801448	0.50	ZC3H12D	zinc finger CCCH-type containing 12D	2897	0.23
chr3_18483093_18483271	0.50	SATB1	SATB homeobox 1	2917	0.27
chr17_17656723_17656874	0.50	RAI1-AS1	RAI1 antisense RNA 1	17337	0.13
chr5_130606159_130606310	0.50	CDC42SE2	CDC42 small effector 2	6441	0.3
chr1_114414835_114414986	0.50	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	529	0.68
chr1_40527104_40527255	0.50	CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	20625	0.16
chr1_67235326_67235808	0.49	TCTEX1D1	Tctex1 domain containing 1	17424	0.16
chr2_38600753_38600904	0.49	ATL2	atlastin GTPase 2	2538	0.41
chr17_38021542_38021693	0.49	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1176	0.38
chr13_50810191_50810488	0.49	ENSG00000221198	.	127034	0.05
chr1_117301810_117301961	0.48	CD2	CD2 molecule	4796	0.25
chr8_29955696_29955905	0.48	LEPROTL1	leptin receptor overlapping transcript-like 1	2635	0.22
chr12_56414859_56415059	0.48	IKZF4	IKAROS family zinc finger 4 (Eos)	95	0.93
chr11_128701010_128701215	0.48	KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	11317	0.21
chr10_182832_182983	0.48	ZMYND11	zinc finger, MYND-type containing 11	1458	0.46
chrX_57937187_57937346	0.48	ZXDA	zinc finger, X-linked, duplicated A	199	0.97
chr4_84029920_84030071	0.48	PLAC8	placenta-specific 8	1001	0.62
chr3_105486134_105486285	0.47	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	65164	0.15
chr12_62658631_62659028	0.47	USP15	ubiquitin specific peptidase 15	4620	0.23
chr7_24635883_24636034	0.47	MPP6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	22326	0.23
chr1_89736661_89736812	0.47	GBP5	guanylate binding protein 5	190	0.95
chr2_74432517_74432668	0.47	MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	6849	0.14
chr1_193431561_193431712	0.46	ENSG00000252241	.	269438	0.02
chr19_2553269_2553420	0.46	ENSG00000252962	.	50205	0.09
chr2_153586089_153586240	0.46	PRPF40A	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	11669	0.23
chr14_102290508_102290727	0.46	CTD-2017C7.2		13959	0.14
chr1_161509241_161509392	0.46	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	10263	0.12
chr13_43649218_43649369	0.46	DNAJC15	DnaJ (Hsp40) homolog, subfamily C, member 15	51954	0.17
chr5_118670477_118670756	0.46	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	1746	0.39
chr10_22622036_22622322	0.45	BMI1	BMI1 polycomb ring finger oncogene	6731	0.15
chr1_41134452_41134677	0.45	RIMS3	regulating synaptic membrane exocytosis 3	3235	0.21
chr18_60192686_60192837	0.45	ZCCHC2	zinc finger, CCHC domain containing 2	1909	0.45
chr14_52739518_52739669	0.45	PTGDR	prostaglandin D2 receptor (DP)	5063	0.28
chr4_25861951_25862197	0.45	SEL1L3	sel-1 suppressor of lin-12-like 3 (C. elegans)	179	0.97
chrX_139671119_139671270	0.45	SOX3	SRY (sex determining region Y)-box 3	83969	0.09
chr8_29936071_29936255	0.45	TMEM66	transmembrane protein 66	3777	0.18
chr20_52198944_52199193	0.45	ZNF217	zinc finger protein 217	568	0.75
chr12_6554914_6555065	0.45	CD27	CD27 molecule	956	0.36
chrX_49128183_49128678	0.45	PPP1R3F	protein phosphatase 1, regulatory subunit 3F	1346	0.25
chrX_40029350_40029589	0.44	BCOR	BCL6 corepressor	7104	0.32
chr3_43332941_43333092	0.44	SNRK	SNF related kinase	4938	0.21
chr4_48140813_48140964	0.44	TXK	TXK tyrosine kinase	4615	0.19
chr1_29254771_29254973	0.44	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	13781	0.18
chr20_7325062_7325213	0.44	ENSG00000240584	.	289361	0.01
chr7_21470822_21470973	0.44	SP4	Sp4 transcription factor	3236	0.24
chr11_8189932_8190374	0.44	RIC3	RIC3 acetylcholine receptor chaperone	383	0.89
chr12_62652703_62652854	0.44	FAM19A2	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	174	0.93
chr9_88966677_88967164	0.43	ZCCHC6	zinc finger, CCHC domain containing 6	701	0.75
chr18_33550373_33550669	0.43	C18orf21	chromosome 18 open reading frame 21	1525	0.4
chr8_91018366_91018555	0.43	DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	4715	0.25
chrX_32480478_32480629	0.43	DMD	dystrophin	113926	0.07
chr15_86127009_86127191	0.43	RP11-815J21.2		3691	0.21
chr14_22985583_22985743	0.42	TRAJ15	T cell receptor alpha joining 15	12917	0.1
chr12_25206187_25206540	0.42	LRMP	lymphoid-restricted membrane protein	689	0.71
chr1_158901738_158901918	0.42	PYHIN1	pyrin and HIN domain family, member 1	470	0.84
chr16_9188277_9188428	0.42	C16orf72	chromosome 16 open reading frame 72	2847	0.22
chr2_26016925_26017076	0.42	ASXL2	additional sex combs like 2 (Drosophila)	13822	0.24
chr1_150737104_150737638	0.42	CTSS	cathepsin S	897	0.5
chr2_26016338_26016489	0.42	ASXL2	additional sex combs like 2 (Drosophila)	13235	0.24
chr3_4782748_4782978	0.42	ENSG00000239126	.	137523	0.05
chr5_54795571_54795722	0.42	ENSG00000265135	.	9108	0.22
chr8_117171964_117172115	0.42	ENSG00000221793	.	23041	0.26
chr19_16255232_16255383	0.42	HSH2D	hematopoietic SH2 domain containing	761	0.53
chr10_82215597_82215808	0.42	TSPAN14	tetraspanin 14	1591	0.41
chr11_94960734_94960891	0.42	RP11-712B9.2		2538	0.31
chr6_100428659_100428810	0.42	MCHR2-AS1	MCHR2 antisense RNA 1	13086	0.24
chr12_9821284_9821435	0.42	CLEC2D	C-type lectin domain family 2, member D	950	0.44
chr8_134069456_134069607	0.42	SLA	Src-like-adaptor	3072	0.32
chr9_132800038_132800189	0.41	FNBP1	formin binding protein 1	5328	0.21
chr7_142556554_142556705	0.41	EPHB6	EPH receptor B6	3806	0.19
chr1_160680341_160680580	0.41	CD48	CD48 molecule	1133	0.45
chrX_106955304_106955502	0.41	TSC22D3	TSC22 domain family, member 3	4228	0.27
chr1_198610198_198610371	0.41	PTPRC	protein tyrosine phosphatase, receptor type, C	1992	0.4
chr10_6103505_6103656	0.41	IL2RA	interleukin 2 receptor, alpha	673	0.64
chr6_143166335_143166733	0.41	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	8350	0.29
chr3_172186897_172187048	0.41	GHSR	growth hormone secretagogue receptor	20726	0.22
chr17_56407127_56407278	0.41	BZRAP1-AS1	BZRAP1 antisense RNA 1	236	0.8
chr14_61790473_61790699	0.41	ENSG00000247287	.	1050	0.4
chr11_72759124_72759335	0.41	FCHSD2	FCH and double SH3 domains 2	59172	0.12
chr15_64888931_64889431	0.40	ENSG00000207223	.	55906	0.09
chr5_22755862_22756013	0.40	CDH12	cadherin 12, type 2 (N-cadherin 2)	97513	0.09
chr1_174935570_174935876	0.40	RABGAP1L	RAB GTPase activating protein 1-like	1818	0.28
chr10_90610482_90610633	0.40	ANKRD22	ankyrin repeat domain 22	1018	0.52
chr3_177314355_177314726	0.40	ENSG00000200288	.	27657	0.25
chr4_159999065_159999216	0.40	ENSG00000206978	.	13590	0.16
chr1_197730742_197731002	0.40	RP11-448G4.4		4423	0.25
chr17_47819247_47819793	0.40	FAM117A	family with sequence similarity 117, member A	17631	0.14
chrX_57618068_57618312	0.40	ZXDB	zinc finger, X-linked, duplicated B	79	0.99
chr8_132999169_132999320	0.40	EFR3A	EFR3 homolog A (S. cerevisiae)	47096	0.17
chr2_143889428_143889579	0.40	ARHGAP15	Rho GTPase activating protein 15	2620	0.37
chr7_136910239_136910390	0.40	hsa-mir-490	hsa-mir-490	43460	0.18
chr20_43599792_43600332	0.40	STK4	serine/threonine kinase 4	4895	0.16
chrX_12862286_12862452	0.40	TLR7	toll-like receptor 7	22833	0.19
chr11_3881667_3881833	0.40	STIM1	stromal interaction molecule 1	4338	0.12
chr2_60904108_60904259	0.40	ENSG00000242158	.	36343	0.16
chr6_108143886_108144261	0.39	SCML4	sex comb on midleg-like 4 (Drosophila)	1443	0.53
chr16_31887817_31887976	0.39	ZNF267	zinc finger protein 267	2509	0.33
chrX_41779510_41779661	0.39	ENSG00000251807	.	983	0.58
chr10_70362033_70362257	0.39	TET1	tet methylcytosine dioxygenase 1	41732	0.13
chr15_81589438_81589936	0.39	IL16	interleukin 16	433	0.84
chr1_92945471_92945622	0.39	GFI1	growth factor independent 1 transcription repressor	3965	0.31
chr11_23103600_23103751	0.39	CCDC179	coiled-coil domain containing 179	221703	0.02
chr8_22299319_22300279	0.39	PPP3CC	protein phosphatase 3, catalytic subunit, gamma isozyme	921	0.52
chr10_26737911_26738372	0.38	APBB1IP	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	10787	0.27
chr14_22978649_22978851	0.38	TRAJ15	T cell receptor alpha joining 15	19830	0.09
chr10_64396930_64397136	0.38	ZNF365	zinc finger protein 365	6500	0.25
chr12_92525894_92526627	0.38	C12orf79	chromosome 12 open reading frame 79	4537	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.6	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.3	1.0	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.2	0.5	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.2	0.4	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2	1.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.2	1.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.2	0.6	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.2	1.5	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2	0.7	GO:0002913	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.2	0.5	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.2	0.3	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.3	GO:0006154	adenosine catabolic process(GO:0006154)
0.1	0.8	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.6	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1	0.4	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	0.3	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	0.5	GO:0042989	sequestering of actin monomers(GO:0042989)
0.1	0.3	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0034114	heterotypic cell-cell adhesion(GO:0034113) regulation of heterotypic cell-cell adhesion(GO:0034114)
0.1	0.1	GO:0002517	tolerance induction to self antigen(GO:0002513) T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.1	0.4	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.3	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.3	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.5	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.3	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.3	GO:0090502	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) cleavage involved in rRNA processing(GO:0000469) endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479) RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1	0.3	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.1	0.4	GO:0008354	germ cell migration(GO:0008354)
0.1	0.2	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1	0.3	GO:2000330	T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.1	0.6	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	0.3	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.1	0.3	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1	0.2	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.1	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.2	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.1	0.2	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.1	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.1	0.2	GO:0045056	transcytosis(GO:0045056)
0.1	0.2	GO:0071883	adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1	0.2	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1	0.2	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1	0.3	GO:0021535	cell migration in hindbrain(GO:0021535)
0.1	0.2	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.1	0.1	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.2	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.2	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.4	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.3	GO:0048505	regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0	0.5	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.2	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	0.3	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.2	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0010536	regulation of activation of Janus kinase activity(GO:0010533) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.2	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.3	GO:0015671	oxygen transport(GO:0015671)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.6	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.3	GO:0002467	germinal center formation(GO:0002467)
0.0	0.2	GO:0046855	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0	0.1	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.2	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.2	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.2	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.5	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.2	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.0	0.2	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.3	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.2	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.4	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.1	GO:0045006	DNA deamination(GO:0045006)
0.0	0.2	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.2	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.1	GO:0009188	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.2	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.3	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.0	GO:0071545	inositol phosphate catabolic process(GO:0071545)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0043247	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.1	GO:0002857	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.3	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.3	GO:0008105	asymmetric protein localization(GO:0008105)
0.0	0.1	GO:0071034	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.1	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.2	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.7	GO:0006997	nucleus organization(GO:0006997)
0.0	0.1	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.4	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0031943	regulation of glucocorticoid metabolic process(GO:0031943)
0.0	0.1	GO:0030033	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.1	GO:1903313	regulation of mRNA 3'-end processing(GO:0031440) positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) layer formation in cerebral cortex(GO:0021819) telencephalon glial cell migration(GO:0022030)
0.0	0.5	GO:0019433	triglyceride catabolic process(GO:0019433)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.1	GO:0042416	dopamine biosynthetic process(GO:0042416)
0.0	0.1	GO:0039694	single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0	0.1	GO:0010624	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.0	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.3	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.3	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0042976	activation of Janus kinase activity(GO:0042976)
0.0	0.0	GO:0052308	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.2	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.0	0.0	GO:0070266	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0010823	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	0.2	GO:1904031	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.2	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.2	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	1.2	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.0	GO:0034244	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.0	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.0	GO:0043501	skeletal muscle adaptation(GO:0043501)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.4	GO:0016574	histone ubiquitination(GO:0016574)
0.0	0.0	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0019060	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.0	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.3	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0046471	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.2	GO:0031648	protein destabilization(GO:0031648)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.0	GO:0003171	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.1	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.2	GO:0016558	protein import into peroxisome matrix(GO:0016558)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0090312	regulation of protein deacetylation(GO:0090311) positive regulation of protein deacetylation(GO:0090312)
0.0	0.2	GO:0006906	vesicle fusion(GO:0006906)
0.0	0.0	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.1	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.1	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.9	GO:0072422	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in cell cycle checkpoint(GO:0072395) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in mitotic cell cycle checkpoint(GO:0072413) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) signal transduction involved in mitotic DNA damage checkpoint(GO:1902402) signal transduction involved in mitotic DNA integrity checkpoint(GO:1902403)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.1	GO:0048641	regulation of skeletal muscle tissue development(GO:0048641)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.0	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0033567	DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0	0.0	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0072698	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.0	GO:0002874	chronic inflammatory response to antigenic stimulus(GO:0002439) regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.0	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.0	GO:2001021	negative regulation of response to DNA damage stimulus(GO:2001021)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.5	GO:0000186	activation of MAPKK activity(GO:0000186)
0.0	0.1	GO:0048664	neuron fate determination(GO:0048664)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.1	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.1	GO:0043631	RNA polyadenylation(GO:0043631)
0.0	0.0	GO:0070601	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0006513	protein monoubiquitination(GO:0006513)
0.0	0.1	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein(GO:0042523)
0.0	0.2	GO:0002228	natural killer cell mediated immunity(GO:0002228) natural killer cell mediated cytotoxicity(GO:0042267)
0.0	0.2	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.0	GO:0071462	cellular response to water stimulus(GO:0071462)
0.0	0.0	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.0	0.3	GO:0046329	negative regulation of JNK cascade(GO:0046329)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.0	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.2	GO:0043489	RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0	0.0	GO:0052312	modulation of transcription in other organism involved in symbiotic interaction(GO:0052312)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0050710	negative regulation of cytokine secretion(GO:0050710)
0.0	0.0	GO:0034086	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.1	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.1	GO:0045815	positive regulation of gene expression, epigenetic(GO:0045815)
0.0	0.0	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.6	GO:0006968	cellular defense response(GO:0006968)
0.0	0.3	GO:0006071	glycerol metabolic process(GO:0006071)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:0034372	triglyceride-rich lipoprotein particle remodeling(GO:0034370) very-low-density lipoprotein particle remodeling(GO:0034372)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.6	GO:0070646	protein modification by small protein removal(GO:0070646)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0051322	anaphase(GO:0051322)
0.0	0.0	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.0	GO:0001914	regulation of T cell mediated cytotoxicity(GO:0001914)
0.0	0.0	GO:0048147	negative regulation of fibroblast proliferation(GO:0048147)
0.0	0.0	GO:0006684	sphingomyelin metabolic process(GO:0006684)
0.0	0.2	GO:0007062	sister chromatid cohesion(GO:0007062)
0.0	0.1	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.0	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.0	GO:1901796	regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516) regulation of signal transduction by p53 class mediator(GO:1901796)
0.0	0.0	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.0	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.0	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.0	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.2	GO:0051220	cytoplasmic sequestering of protein(GO:0051220)
0.0	0.2	GO:0000018	regulation of DNA recombination(GO:0000018)
0.0	0.0	GO:0051447	negative regulation of meiotic nuclear division(GO:0045835) negative regulation of meiotic cell cycle(GO:0051447)
0.0	0.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.0	GO:2000380	regulation of mesodermal cell fate specification(GO:0042661) lateral mesoderm development(GO:0048368) regulation of mesoderm development(GO:2000380)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.2	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0	0.1	GO:0007080	mitotic metaphase plate congression(GO:0007080)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.2	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.0	0.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.0	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.1	GO:0000718	nucleotide-excision repair, DNA damage removal(GO:0000718) DNA excision(GO:0044349)
0.0	0.1	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.0	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.1	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.0	GO:0048311	mitochondrion distribution(GO:0048311)
0.0	0.2	GO:0018208	peptidyl-proline modification(GO:0018208)
0.0	0.0	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0006743	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.0	GO:0051775	response to redox state(GO:0051775)
0.0	0.1	GO:0002002	regulation of angiotensin levels in blood(GO:0002002)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.0	GO:0032769	negative regulation of monooxygenase activity(GO:0032769)
0.0	0.0	GO:1904729	regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.0	0.0	GO:0030865	cortical cytoskeleton organization(GO:0030865)
0.0	0.1	GO:0007176	regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0	0.0	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0	0.1	GO:0030149	sphingolipid catabolic process(GO:0030149)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.7	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.2	0.7	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.2	0.5	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	0.6	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	0.8	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.2	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1	0.2	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.2	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	0.2	GO:0032009	early phagosome(GO:0032009)
0.1	0.4	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.1	0.7	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	0.2	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.2	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.2	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0002142	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.7	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.2	GO:0042382	paraspeckles(GO:0042382)
0.0	0.3	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.7	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.6	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.5	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.2	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.2	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	0.3	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.8	GO:0008305	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	3.0	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.4	GO:0031519	PcG protein complex(GO:0031519)
0.0	1.0	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.0	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.2	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0045283	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.2	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.0	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.2	GO:0016235	aggresome(GO:0016235)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.3	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0061200	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	1.6	GO:0016607	nuclear speck(GO:0016607)
0.0	0.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.6	GO:0016605	PML body(GO:0016605)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	1.1	GO:0032993	protein-DNA complex(GO:0032993)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.0	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.5	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.3	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.6	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	0.1	GO:0030686	90S preribosome(GO:0030686)
0.0	0.0	GO:0005827	polar microtubule(GO:0005827)
0.0	0.2	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	0.1	GO:0000178	exosome (RNase complex)(GO:0000178)
0.0	0.0	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0043209	myelin sheath(GO:0043209)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.5	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.0	0.1	GO:0001772	immunological synapse(GO:0001772)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.2	0.7	GO:0042608	T cell receptor binding(GO:0042608)
0.2	0.7	GO:0050544	arachidonic acid binding(GO:0050544)
0.2	0.6	GO:0051380	norepinephrine binding(GO:0051380)
0.1	1.3	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.1	0.4	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.3	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.1	0.5	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.4	GO:0001846	opsonin binding(GO:0001846)
0.1	0.3	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1	0.6	GO:0030507	spectrin binding(GO:0030507)
0.1	0.2	GO:0031685	adenosine receptor binding(GO:0031685)
0.1	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.1	0.2	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.6	GO:0005522	profilin binding(GO:0005522)
0.1	1.1	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1	0.2	GO:0001848	complement binding(GO:0001848)
0.1	0.2	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.1	0.3	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1	0.5	GO:0043208	glycosphingolipid binding(GO:0043208)
0.1	0.2	GO:0035197	siRNA binding(GO:0035197)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	1.4	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.2	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1	0.2	GO:0030151	molybdenum ion binding(GO:0030151)
0.1	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.1	0.3	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.1	0.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.2	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.2	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	2.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.3	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.3	GO:0005521	lamin binding(GO:0005521)
0.0	0.6	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.2	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.7	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.2	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.2	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.3	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.3	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	1.1	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.3	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.3	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.4	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.4	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.3	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.3	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.2	GO:0034452	dynactin binding(GO:0034452)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.2	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.2	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.3	GO:0042166	acetylcholine binding(GO:0042166)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.2	GO:0004568	chitinase activity(GO:0004568)
0.0	0.2	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.3	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.3	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.8	GO:0003823	antigen binding(GO:0003823)
0.0	0.2	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.2	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0070402	NADPH binding(GO:0070402)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.2	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.4	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.4	GO:0019213	deacetylase activity(GO:0019213)
0.0	0.2	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.2	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.3	GO:0043499	obsolete eukaryotic cell surface binding(GO:0043499)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.2	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.1	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.2	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.0	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.6	GO:0019783	ubiquitin-like protein-specific protease activity(GO:0019783)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.3	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.0	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.2	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.4	GO:0000049	tRNA binding(GO:0000049)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0019206	nucleoside kinase activity(GO:0019206)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.0	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.0	GO:0045502	dynein binding(GO:0045502)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.2	GO:0004522	ribonuclease A activity(GO:0004522)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.3	GO:0019003	GDP binding(GO:0019003)
0.0	0.0	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0061630	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.0	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0	0.3	GO:0016859	cis-trans isomerase activity(GO:0016859)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0042287	MHC protein binding(GO:0042287)
0.0	0.1	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.1	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.3	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.2	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0	0.1	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.0	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.2	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.0	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.1	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.9	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	0.7	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	2.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	0.9	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	1.0	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	1.8	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	1.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.6	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.2	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.7	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.5	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.2	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.4	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.2	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.3	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.6	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.3	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	0.0	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.3	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.2	PID EPO PATHWAY	EPO signaling pathway
0.0	0.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.5	PID BARD1 PATHWAY	BARD1 signaling events
0.0	0.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	0.3	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.2	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.4	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.3	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.3	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.2	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.2	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.0	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	0.1	PID RAS PATHWAY	Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	1.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	0.8	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	1.0	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	0.7	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	0.9	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	0.2	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	1.0	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	0.2	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
0.0	0.9	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	1.7	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	1.7	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.7	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.3	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.6	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.4	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.5	REACTOME BOTULINUM NEUROTOXICITY	Genes involved in Botulinum neurotoxicity
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.4	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.3	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.4	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.1	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.8	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.3	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.3	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.3	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.3	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.0	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	1.2	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	0.3	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.7	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.5	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.8	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.0	0.0	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.2	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	0.0	REACTOME PERK REGULATED GENE EXPRESSION	Genes involved in PERK regulated gene expression
0.0	0.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.2	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.2	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.2	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.5	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.3	REACTOME RNA POL I TRANSCRIPTION	Genes involved in RNA Polymerase I Transcription
0.0	0.4	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.4	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.0	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.1	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.3	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.1	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.2	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.0	0.0	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	0.4	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.0	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen

Results for SIX6

Z-value: 1.58

Motif logo

Transcription factors associated with SIX6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the SIX6 motif across conditions

Conditions sorted by the z-value of the SIX6 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: