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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SMAD3

Z-value: 0.73

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Transcription factors associated with SMAD3

Gene Symbol	Gene ID	Gene Info
SMAD3 Ensembl NCBI GeneCards UniProt	ENSG00000166949.11	SMAD3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SMAD3	chr15_67311354_67311505	44672	0.186105	-0.87	2.5e-03	Click!
SMAD3	chr15_67467161_67467312	8367	0.225281	-0.85	3.5e-03	Click!
SMAD3	chr15_67413509_67413942	4329	0.275328	-0.81	8.3e-03	Click!
SMAD3	chr15_67397321_67397472	6379	0.268255	-0.80	9.6e-03	Click!
SMAD3	chr15_67394209_67394360	3267	0.324710	-0.77	1.6e-02	Click!

Activity of the SMAD3 motif across conditions

Conditions sorted by the z-value of the SMAD3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_118481086_118481679	0.25	PHLDB1	pleckstrin homology-like domain, family B, member 1	3024	0.16
chr10_128250315_128250594	0.24	ENSG00000221717	.	4821	0.29
chr13_27927814_27927965	0.24	ENSG00000252247	.	10006	0.16
chr7_40510514_40510679	0.23	AC004988.1		75931	0.12
chr2_149574916_149575083	0.22	ENSG00000222126	.	8405	0.24
chr1_110455050_110455346	0.21	CSF1	colony stimulating factor 1 (macrophage)	1590	0.37
chr11_44008945_44009331	0.20	C11orf96	chromosome 11 open reading frame 96	45083	0.11
chr17_77767116_77767731	0.19	CBX8	chromobox homolog 8	3492	0.16
chr1_159823893_159825316	0.19	C1orf204	chromosome 1 open reading frame 204	533	0.6
chr7_100200060_100200259	0.18	PCOLCE	procollagen C-endopeptidase enhancer	359	0.52
chrX_106873865_106874016	0.18	PRPS1	phosphoribosyl pyrophosphate synthetase 1	2147	0.39
chr16_81551895_81552046	0.18	CMIP	c-Maf inducing protein	23016	0.25
chr16_82769509_82769673	0.18	RP11-22H5.2		37333	0.19
chr2_191915750_191915901	0.18	ENSG00000231858	.	29573	0.14
chr6_45705656_45705807	0.17	ENSG00000252738	.	91890	0.09
chr2_106712942_106713243	0.17	C2orf40	chromosome 2 open reading frame 40	30836	0.19
chr2_42275788_42276453	0.17	PKDCC	protein kinase domain containing, cytoplasmic	960	0.61
chr5_143171507_143171658	0.17	HMHB1	histocompatibility (minor) HB-1	20144	0.27
chr5_15501266_15501663	0.17	FBXL7	F-box and leucine-rich repeat protein 7	83	0.99
chr4_148471587_148471738	0.17	EDNRA	endothelin receptor type A	64828	0.11
chr5_154832195_154832346	0.17	ENSG00000221131	.	427910	0.01
chr10_113968621_113968821	0.17	GPAM	glycerol-3-phosphate acyltransferase, mitochondrial	25196	0.23
chrX_57162974_57163409	0.17	SPIN2A	spindlin family, member 2A	239	0.93
chr12_50067665_50067882	0.17	FMNL3	formin-like 3	33230	0.11
chr4_96336664_96336815	0.16	UNC5C	unc-5 homolog C (C. elegans)	133384	0.05
chr20_56283949_56284203	0.16	PMEPA1	prostate transmembrane protein, androgen induced 1	740	0.76
chr15_41202299_41202450	0.16	VPS18	vacuolar protein sorting 18 homolog (S. cerevisiae)	15709	0.1
chr10_50285208_50285359	0.15	VSTM4	V-set and transmembrane domain containing 4	38271	0.12
chr20_35643588_35643790	0.15	RBL1	retinoblastoma-like 1 (p107)	52769	0.13
chr6_127839316_127839467	0.15	SOGA3	SOGA family member 3	645	0.78
chr5_135365151_135365507	0.15	TGFBI	transforming growth factor, beta-induced, 68kDa	638	0.75
chr5_39204467_39204671	0.15	FYB	FYN binding protein	1440	0.55
chrX_103381032_103381192	0.15	SLC25A53	solute carrier family 25, member 53	20596	0.16
chr11_76514494_76514645	0.15	RP11-21L23.2		3161	0.19
chr11_119293301_119293628	0.15	THY1	Thy-1 cell surface antigen	192	0.91
chr3_65905504_65905655	0.15	ENSG00000264716	.	21343	0.18
chr7_94026391_94026542	0.15	COL1A2	collagen, type I, alpha 2	2593	0.39
chr8_10000960_10001195	0.15	MSRA	methionine sulfoxide reductase A	47840	0.15
chr2_109790043_109790205	0.15	ENSG00000264934	.	32080	0.2
chr13_20413212_20413363	0.14	RP11-61K9.2		2680	0.24
chr22_37272954_37273105	0.14	NCF4	neutrophil cytosolic factor 4, 40kDa	4850	0.15
chr8_18694624_18694775	0.14	PSD3	pleckstrin and Sec7 domain containing 3	17185	0.22
chr2_213279556_213279778	0.14	ENSG00000221782	.	11417	0.25
chr12_133770634_133770785	0.14	ZNF268	zinc finger protein 268	2626	0.19
chr5_148793966_148794117	0.14	ENSG00000208035	.	14440	0.12
chr1_236147536_236147733	0.14	ENSG00000206803	.	68919	0.09
chr12_120241388_120241613	0.14	CIT	citron (rho-interacting, serine/threonine kinase 21)	313	0.92
chr19_3606102_3607092	0.14	TBXA2R	thromboxane A2 receptor	61	0.89
chr9_115811689_115811840	0.14	ZFP37	ZFP37 zinc finger protein	7204	0.26
chr16_66223356_66223587	0.14	ENSG00000201999	.	112241	0.06
chr9_133655839_133655990	0.14	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	54539	0.13
chr11_132863892_132864419	0.14	OPCML	opioid binding protein/cell adhesion molecule-like	50492	0.18
chr11_112125884_112126163	0.14	AP002884.2	LOC100132686 protein; Uncharacterized protein	4965	0.13
chr19_1361544_1361801	0.14	MUM1	melanoma associated antigen (mutated) 1	5309	0.1
chr5_39211790_39211941	0.14	FYB	FYN binding protein	7800	0.29
chr17_40933524_40933675	0.14	WNK4	WNK lysine deficient protein kinase 4	903	0.35
chr12_12961145_12961613	0.14	DDX47	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	4871	0.18
chr3_28958326_28958575	0.14	ENSG00000238470	.	94283	0.09
chr16_31022230_31022574	0.14	STX1B	syntaxin 1B	453	0.64
chr6_56707059_56707245	0.14	DST	dystonin	791	0.6
chr4_187622974_187623192	0.14	FAT1	FAT atypical cadherin 1	21926	0.25
chrX_109246139_109246998	0.14	TMEM164	transmembrane protein 164	225	0.95
chr2_183289157_183289308	0.14	PDE1A	phosphodiesterase 1A, calmodulin-dependent	2517	0.42
chr19_41195400_41196566	0.14	NUMBL	numb homolog (Drosophila)-like	44	0.96
chr18_34914843_34915294	0.14	RP11-797E24.3		60645	0.13
chr12_111843881_111845308	0.14	SH2B3	SH2B adaptor protein 3	842	0.62
chr1_178340504_178341006	0.13	RASAL2	RAS protein activator like 2	30149	0.22
chr8_60000977_60001151	0.13	RP11-25K19.1		30535	0.17
chrX_39964334_39965624	0.13	BCOR	BCL6 corepressor	8323	0.32
chr7_90330496_90330666	0.13	CDK14	cyclin-dependent kinase 14	7999	0.29
chrX_139608216_139608367	0.13	SOX3	SRY (sex determining region Y)-box 3	21066	0.26
chr4_147576450_147576671	0.13	ENSG00000264323	.	16147	0.21
chr13_27135563_27135714	0.13	WASF3	WAS protein family, member 3	3751	0.35
chr14_22938246_22938397	0.13	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	6975	0.11
chrX_53349448_53350467	0.13	IQSEC2	IQ motif and Sec7 domain 2	565	0.73
chr11_64512499_64513555	0.13	RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	99	0.95
chr1_240629057_240629208	0.13	FMN2	formin 2	8350	0.21
chr19_8675123_8675468	0.13	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif, 10	290	0.88
chr11_69851843_69851994	0.13	ANO1-AS2	ANO1 antisense RNA 2 (head to head)	69536	0.09
chr16_23706248_23706462	0.13	ERN2	endoplasmic reticulum to nucleus signaling 2	274	0.86
chr5_53810721_53810989	0.13	SNX18	sorting nexin 18	2734	0.38
chr6_159235122_159235362	0.13	EZR-AS1	EZR antisense RNA 1	3801	0.21
chr8_128957071_128957260	0.12	TMEM75	transmembrane protein 75	3426	0.25
chr15_68872500_68872651	0.12	CORO2B	coronin, actin binding protein, 2B	1002	0.69
chr7_152219742_152220164	0.12	ENSG00000199404	.	70223	0.09
chr12_88917218_88917369	0.12	KITLG	KIT ligand	56945	0.14
chr7_100032883_100033657	0.12	RP11-758P17.2		390	0.45
chr11_114175854_114176005	0.12	NNMT	nicotinamide N-methyltransferase	7056	0.22
chr11_36052910_36053061	0.12	ENSG00000263389	.	21337	0.21
chr7_55545563_55545779	0.12	VOPP1	vesicular, overexpressed in cancer, prosurvival protein 1	38099	0.19
chr20_13229977_13230206	0.12	RP5-1077I2.3		4075	0.24
chr14_77370360_77370542	0.12	ENSG00000223174	.	13845	0.2
chr19_3094656_3095580	0.12	GNA11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	710	0.53
chr17_39969274_39969651	0.12	FKBP10	FK506 binding protein 10, 65 kDa	279	0.68
chr20_33871790_33873092	0.12	EIF6	eukaryotic translation initiation factor 6	77	0.88
chr12_104973868_104974019	0.12	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	8683	0.24
chr1_201915320_201915636	0.12	LMOD1	leiomodin 1 (smooth muscle)	237	0.87
chr3_70881422_70881573	0.12	ENSG00000206939	.	23996	0.24
chr8_6693007_6693158	0.12	DEFB1	defensin, beta 1	42462	0.14
chr8_101117971_101118266	0.12	RGS22	regulator of G-protein signaling 22	72	0.97
chr12_12016436_12016587	0.12	ETV6	ets variant 6	22360	0.26
chr17_29036450_29037561	0.12	ENSG00000241631	.	7212	0.17
chr8_93066568_93066719	0.12	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	8548	0.31
chr8_77585853_77586055	0.12	ZFHX4	zinc finger homeobox 4	7500	0.24
chr6_20680738_20680889	0.12	RP3-348I23.2		120112	0.06
chr16_73248437_73248618	0.12	C16orf47	chromosome 16 open reading frame 47	70181	0.13
chr19_45754620_45755932	0.12	MARK4	MAP/microtubule affinity-regulating kinase 4	726	0.57
chr9_18476160_18476529	0.12	ADAMTSL1	ADAMTS-like 1	2113	0.45
chr8_119390030_119390181	0.12	AC023590.1	Uncharacterized protein	95624	0.09
chr21_39720894_39721098	0.12	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	52148	0.17
chr18_53537809_53537960	0.12	TCF4	transcription factor 4	205866	0.03
chr15_49082630_49082781	0.11	RP11-485O10.2		7318	0.18
chr1_101186979_101187209	0.11	VCAM1	vascular cell adhesion molecule 1	1774	0.47
chr6_46458824_46459774	0.11	RCAN2	regulator of calcineurin 2	200	0.78
chr12_57527559_57527864	0.11	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	1789	0.2
chr6_106611529_106611909	0.11	RP1-134E15.3		63704	0.11
chr19_14315927_14317134	0.11	LPHN1	latrophilin 1	451	0.77
chr10_90711644_90712353	0.11	ACTA2	actin, alpha 2, smooth muscle, aorta	532	0.73
chr15_101498489_101498640	0.11	LRRK1	leucine-rich repeat kinase 1	39014	0.15
chr17_59361891_59362042	0.11	RP11-332H18.3		98180	0.06
chr5_154033985_154034136	0.11	ENSG00000221552	.	31276	0.14
chr9_99277013_99277426	0.11	CDC14B	cell division cycle 14B	51893	0.13
chr9_132033008_132033468	0.11	ENSG00000220992	.	40242	0.13
chr14_23000842_23001170	0.11	TRAJ15	T cell receptor alpha joining 15	2426	0.17
chr1_25636296_25636447	0.11	TMEM50A	transmembrane protein 50A	28037	0.11
chr11_3070813_3071033	0.11	ENSG00000201616	.	1172	0.38
chr17_42637473_42637723	0.11	FZD2	frizzled family receptor 2	2673	0.27
chr19_47732183_47732562	0.11	BBC3	BCL2 binding component 3	2079	0.22
chr6_158653547_158654353	0.11	ENSG00000265803	.	57934	0.11
chr2_121324572_121324723	0.11	ENSG00000201006	.	84202	0.1
chr5_95768778_95768929	0.11	PCSK1	proprotein convertase subtilisin/kexin type 1	131	0.98
chr22_20105332_20105991	0.11	RANBP1	RAN binding protein 1	185	0.8
chr9_101137213_101137445	0.11	TBC1D2	TBC1 domain family, member 2	119414	0.06
chr10_123276154_123276305	0.11	FGFR2	fibroblast growth factor receptor 2	1536	0.55
chr13_24826013_24826241	0.11	SPATA13	spermatogenesis associated 13	271	0.9
chr12_92270812_92270963	0.11	C12orf79	chromosome 12 open reading frame 79	259910	0.02
chr12_124427345_124427647	0.11	CCDC92	coiled-coil domain containing 92	3824	0.09
chr18_22868744_22868981	0.11	CTD-2006O16.2		13228	0.28
chr12_31783207_31783359	0.11	METTL20	methyltransferase like 20	16811	0.15
chr6_3340953_3341317	0.11	RP11-506K6.4		29239	0.19
chr12_11916647_11916798	0.11	ETV6	ets variant 6	11287	0.29
chr11_76382331_76382482	0.11	LRRC32	leucine rich repeat containing 32	615	0.71
chr16_27256695_27256846	0.11	NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	12371	0.16
chr5_134178464_134178621	0.11	C5orf24	chromosome 5 open reading frame 24	2828	0.25
chr12_93789120_93789411	0.11	NUDT4	nudix (nucleoside diphosphate linked moiety X)-type motif 4	16835	0.14
chr11_19735768_19735975	0.11	NAV2	neuron navigator 2	728	0.74
chr2_171362653_171362804	0.11	AC007277.3		137726	0.05
chr6_143164322_143164558	0.11	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	6256	0.3
chr1_161167282_161167469	0.11	ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif, 4	1468	0.16
chr11_114168512_114168913	0.11	NNMT	nicotinamide N-methyltransferase	106	0.97
chr5_143407637_143407837	0.11	ENSG00000239390	.	112707	0.07
chr18_18549206_18549357	0.11	ROCK1	Rho-associated, coiled-coil containing protein kinase 1	14450	0.28
chr13_60709592_60709946	0.11	DIAPH3-AS2	DIAPH3 antisense RNA 2	9063	0.22
chr11_123300349_123300500	0.10	AP000783.1	Uncharacterized protein	634	0.77
chr11_1893200_1893351	0.10	LSP1	lymphocyte-specific protein 1	1159	0.31
chr1_29308973_29309136	0.10	ENSG00000206704	.	3168	0.29
chr11_2402201_2402352	0.10	CD81	CD81 molecule	1414	0.26
chr15_48927305_48927456	0.10	FBN1	fibrillin 1	10538	0.28
chr22_17671940_17672186	0.10	CECR1	cat eye syndrome chromosome region, candidate 1	8610	0.17
chr5_34622373_34622524	0.10	RAI14	retinoic acid induced 14	33894	0.19
chr21_36936389_36936667	0.10	ENSG00000211590	.	156485	0.04
chr1_113087859_113088010	0.10	RP4-671G15.2		26871	0.14
chr19_46148736_46148888	0.10	EML2	echinoderm microtubule associated protein like 2	75	0.93
chr22_25346545_25346696	0.10	KIAA1671	KIAA1671	2077	0.32
chr13_52158653_52159782	0.10	WDFY2	WD repeat and FYVE domain containing 2	573	0.6
chr2_109202767_109202918	0.10	LIMS1	LIM and senescent cell antigen-like domains 1	1925	0.4
chrX_54555990_54556466	0.10	GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	416	0.88
chr16_87978942_87979129	0.10	BANP	BTG3 associated nuclear protein	5007	0.21
chr4_169616116_169616373	0.10	ENSG00000206613	.	8377	0.21
chr1_156215307_156216024	0.10	PAQR6	progestin and adipoQ receptor family member VI	2157	0.16
chr14_101867418_101867569	0.10	ENSG00000258498	.	159266	0.02
chr13_33850317_33850468	0.10	ENSG00000236581	.	1298	0.49
chrY_7395772_7396011	0.10	ENSG00000252472	.	104692	0.07
chr16_72955812_72956039	0.10	ENSG00000221799	.	62831	0.11
chr13_36492055_36492221	0.10	DCLK1	doublecortin-like kinase 1	62359	0.15
chr10_25971446_25971646	0.10	ENSG00000223019	.	131300	0.05
chr14_99699001_99699256	0.10	AL109767.1		30157	0.18
chr19_8656644_8657344	0.10	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif, 10	86	0.96
chr2_231090060_231090211	0.10	SP110	SP110 nuclear body protein	309	0.48
chr2_219646650_219647418	0.10	CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	555	0.7
chr10_36739274_36739523	0.10	ENSG00000237002	.	11809	0.29
chr20_32030739_32031661	0.10	SNTA1	syntrophin, alpha 1	498	0.77
chr22_30641977_30642328	0.10	RP1-102K2.8		42	0.9
chr1_36042987_36043882	0.10	RP4-728D4.2		104	0.95
chr15_60688893_60689153	0.10	ANXA2	annexin A2	514	0.85
chr1_78005375_78005526	0.10	AK5	adenylate kinase 5	7658	0.25
chr15_65197450_65197821	0.10	ENSG00000264929	.	5197	0.16
chr19_17445022_17445529	0.10	ANO8	anoctamin 8	363	0.48
chr6_43214536_43215130	0.10	TTBK1	tau tubulin kinase 1	894	0.48
chr10_124254663_124255115	0.10	HTRA1	HtrA serine peptidase 1	11318	0.2
chr5_121416588_121416739	0.10	LOX	lysyl oxidase	2683	0.32
chr6_36593181_36593356	0.10	ENSG00000263894	.	2979	0.19
chr14_52346903_52347054	0.10	GNG2	guanine nucleotide binding protein (G protein), gamma 2	2668	0.28
chr12_77309523_77309699	0.10	CSRP2	cysteine and glycine-rich protein 2	36771	0.18
chr2_3497402_3497553	0.10	ADI1	acireductone dioxygenase 1	7110	0.15
chr10_88162500_88162651	0.10	GRID1	glutamate receptor, ionotropic, delta 1	36340	0.16
chr1_211589992_211590552	0.10	TRAF5	TNF receptor-associated factor 5	70566	0.1
chr9_118919385_118919577	0.10	PAPPA	pregnancy-associated plasma protein A, pappalysin 1	3398	0.32
chr7_27404330_27404615	0.10	EVX1-AS	EVX1 antisense RNA	117624	0.04
chr22_41956802_41957044	0.10	CSDC2	cold shock domain containing C2, RNA binding	156	0.93

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0046549	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.1	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.0	0.0	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.1	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0071883	adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.1	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.0	0.1	GO:1903077	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.1	GO:0090281	negative regulation of calcium ion import(GO:0090281)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0016075	rRNA catabolic process(GO:0016075)
0.0	0.1	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.1	GO:0060033	anatomical structure regression(GO:0060033)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.3	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.2	GO:0048535	lymph node development(GO:0048535)
0.0	0.0	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.0	GO:1903054	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.0	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.1	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.0	GO:0071462	cellular response to water stimulus(GO:0071462)
0.0	0.0	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.0	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.0	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.0	GO:0009415	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.0	GO:2001012	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0009886	post-embryonic morphogenesis(GO:0009886)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.0	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	0.1	GO:0048241	epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.1	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.0	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.0	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.0	GO:0032656	regulation of interleukin-13 production(GO:0032656)
0.0	0.1	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0008347	glial cell migration(GO:0008347)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0050655	dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.0	0.1	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0010830	regulation of myotube differentiation(GO:0010830)
0.0	0.0	GO:1901889	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0	0.1	GO:0090083	regulation of inclusion body assembly(GO:0090083)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.1	GO:0005652	nuclear lamina(GO:0005652)
0.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	GO:0018995	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.1	GO:0031512	motile primary cilium(GO:0031512)
0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	GO:0005899	insulin receptor complex(GO:0005899)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.1	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.2	GO:0034235	GPI anchor binding(GO:0034235)
0.1	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1	GO:0070492	oligosaccharide binding(GO:0070492)
0.1	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1	GO:0009374	biotin binding(GO:0009374)
0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.1	GO:0043559	insulin binding(GO:0043559)
0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1	GO:0004954	prostanoid receptor activity(GO:0004954)
0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.1	GO:0043274	phospholipase binding(GO:0043274)
0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1	GO:0051018	protein kinase A binding(GO:0051018)
0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.4	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.1	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor