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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for SMAD3

Z-value: 0.73

Motif logo

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Transcription factors associated with SMAD3

Gene Symbol Gene ID Gene Info
SMAD3
ENSG00000166949.11 SMAD family member 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr15_67311354_67311505SMAD3446720.186105-0.872.5e-03Click!
chr15_67467161_67467312SMAD383670.225281-0.853.5e-03Click!
chr15_67413509_67413942SMAD343290.275328-0.818.3e-03Click!
chr15_67397321_67397472SMAD363790.268255-0.809.6e-03Click!
chr15_67394209_67394360SMAD332670.324710-0.771.6e-02Click!

Activity of the SMAD3 motif across conditions

Conditions sorted by the z-value of the SMAD3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_118481086_118481679 0.25 PHLDB1
 pleckstrin homology-like domain, family B, member 1
 3024
 0.16
chr10_128250315_128250594 0.24 ENSG00000221717
 .
 4821
 0.29
chr13_27927814_27927965 0.24 ENSG00000252247
 .
 10006
 0.16
chr7_40510514_40510679 0.23 AC004988.1
75931
 0.12
chr2_149574916_149575083 0.22 ENSG00000222126
 .
 8405
 0.24
chr1_110455050_110455346 0.21 CSF1
 colony stimulating factor 1 (macrophage)
 1590
 0.37
chr11_44008945_44009331 0.20 C11orf96
 chromosome 11 open reading frame 96
 45083
 0.11
chr17_77767116_77767731 0.19 CBX8
 chromobox homolog 8
 3492
 0.16
chr1_159823893_159825316 0.19 C1orf204
 chromosome 1 open reading frame 204
 533
 0.6
chr7_100200060_100200259 0.18 PCOLCE
 procollagen C-endopeptidase enhancer
 359
 0.52
chrX_106873865_106874016 0.18 PRPS1
 phosphoribosyl pyrophosphate synthetase 1
 2147
 0.39
chr16_81551895_81552046 0.18 CMIP
 c-Maf inducing protein
 23016
 0.25
chr16_82769509_82769673 0.18 RP11-22H5.2
37333
 0.19
chr2_191915750_191915901 0.18 ENSG00000231858
 .
 29573
 0.14
chr6_45705656_45705807 0.17 ENSG00000252738
 .
 91890
 0.09
chr2_106712942_106713243 0.17 C2orf40
 chromosome 2 open reading frame 40
 30836
 0.19
chr2_42275788_42276453 0.17 PKDCC
 protein kinase domain containing, cytoplasmic
 960
 0.61
chr5_143171507_143171658 0.17 HMHB1
 histocompatibility (minor) HB-1
 20144
 0.27
chr5_15501266_15501663 0.17 FBXL7
 F-box and leucine-rich repeat protein 7
 83
 0.99
chr4_148471587_148471738 0.17 EDNRA
 endothelin receptor type A
 64828
 0.11
chr5_154832195_154832346 0.17 ENSG00000221131
 .
 427910
 0.01
chr10_113968621_113968821 0.17 GPAM
 glycerol-3-phosphate acyltransferase, mitochondrial
 25196
 0.23
chrX_57162974_57163409 0.17 SPIN2A
 spindlin family, member 2A
 239
 0.93
chr12_50067665_50067882 0.17 FMNL3
 formin-like 3
 33230
 0.11
chr4_96336664_96336815 0.16 UNC5C
 unc-5 homolog C (C. elegans)
 133384
 0.05
chr20_56283949_56284203 0.16 PMEPA1
 prostate transmembrane protein, androgen induced 1
 740
 0.76
chr15_41202299_41202450 0.16 VPS18
 vacuolar protein sorting 18 homolog (S. cerevisiae)
 15709
 0.1
chr10_50285208_50285359 0.15 VSTM4
 V-set and transmembrane domain containing 4
 38271
 0.12
chr20_35643588_35643790 0.15 RBL1
 retinoblastoma-like 1 (p107)
 52769
 0.13
chr6_127839316_127839467 0.15 SOGA3
 SOGA family member 3
 645
 0.78
chr5_135365151_135365507 0.15 TGFBI
 transforming growth factor, beta-induced, 68kDa
 638
 0.75
chr5_39204467_39204671 0.15 FYB
 FYN binding protein
 1440
 0.55
chrX_103381032_103381192 0.15 SLC25A53
 solute carrier family 25, member 53
 20596
 0.16
chr11_76514494_76514645 0.15 RP11-21L23.2
3161
 0.19
chr11_119293301_119293628 0.15 THY1
 Thy-1 cell surface antigen
 192
 0.91
chr3_65905504_65905655 0.15 ENSG00000264716
 .
 21343
 0.18
chr7_94026391_94026542 0.15 COL1A2
 collagen, type I, alpha 2
 2593
 0.39
chr8_10000960_10001195 0.15 MSRA
 methionine sulfoxide reductase A
 47840
 0.15
chr2_109790043_109790205 0.15 ENSG00000264934
 .
 32080
 0.2
chr13_20413212_20413363 0.14 RP11-61K9.2
2680
 0.24
chr22_37272954_37273105 0.14 NCF4
 neutrophil cytosolic factor 4, 40kDa
 4850
 0.15
chr8_18694624_18694775 0.14 PSD3
 pleckstrin and Sec7 domain containing 3
 17185
 0.22
chr2_213279556_213279778 0.14 ENSG00000221782
 .
 11417
 0.25
chr12_133770634_133770785 0.14 ZNF268
 zinc finger protein 268
 2626
 0.19
chr5_148793966_148794117 0.14 ENSG00000208035
 .
 14440
 0.12
chr1_236147536_236147733 0.14 ENSG00000206803
 .
 68919
 0.09
chr12_120241388_120241613 0.14 CIT
 citron (rho-interacting, serine/threonine kinase 21)
 313
 0.92
chr19_3606102_3607092 0.14 TBXA2R
 thromboxane A2 receptor
 61
 0.89
chr9_115811689_115811840 0.14 ZFP37
 ZFP37 zinc finger protein
 7204
 0.26
chr16_66223356_66223587 0.14 ENSG00000201999
 .
 112241
 0.06
chr9_133655839_133655990 0.14 ABL1
 c-abl oncogene 1, non-receptor tyrosine kinase
 54539
 0.13
chr11_132863892_132864419 0.14 OPCML
 opioid binding protein/cell adhesion molecule-like
 50492
 0.18
chr11_112125884_112126163 0.14 AP002884.2
 LOC100132686 protein; Uncharacterized protein
 4965
 0.13
chr19_1361544_1361801 0.14 MUM1
 melanoma associated antigen (mutated) 1
 5309
 0.1
chr5_39211790_39211941 0.14 FYB
 FYN binding protein
 7800
 0.29
chr17_40933524_40933675 0.14 WNK4
 WNK lysine deficient protein kinase 4
 903
 0.35
chr12_12961145_12961613 0.14 DDX47
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
 4871
 0.18
chr3_28958326_28958575 0.14 ENSG00000238470
 .
 94283
 0.09
chr16_31022230_31022574 0.14 STX1B
 syntaxin 1B
 453
 0.64
chr6_56707059_56707245 0.14 DST
 dystonin
 791
 0.6
chr4_187622974_187623192 0.14 FAT1
 FAT atypical cadherin 1
 21926
 0.25
chrX_109246139_109246998 0.14 TMEM164
 transmembrane protein 164
 225
 0.95
chr2_183289157_183289308 0.14 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
 2517
 0.42
chr19_41195400_41196566 0.14 NUMBL
 numb homolog (Drosophila)-like
 44
 0.96
chr18_34914843_34915294 0.14 RP11-797E24.3
60645
 0.13
chr12_111843881_111845308 0.14 SH2B3
 SH2B adaptor protein 3
 842
 0.62
chr1_178340504_178341006 0.13 RASAL2
 RAS protein activator like 2
 30149
 0.22
chr8_60000977_60001151 0.13 RP11-25K19.1
30535
 0.17
chrX_39964334_39965624 0.13 BCOR
 BCL6 corepressor
 8323
 0.32
chr7_90330496_90330666 0.13 CDK14
 cyclin-dependent kinase 14
 7999
 0.29
chrX_139608216_139608367 0.13 SOX3
 SRY (sex determining region Y)-box 3
 21066
 0.26
chr4_147576450_147576671 0.13 ENSG00000264323
 .
 16147
 0.21
chr13_27135563_27135714 0.13 WASF3
 WAS protein family, member 3
 3751
 0.35
chr14_22938246_22938397 0.13 TRAJ60
 T cell receptor alpha joining 60 (pseudogene)
 6975
 0.11
chrX_53349448_53350467 0.13 IQSEC2
 IQ motif and Sec7 domain 2
 565
 0.73
chr11_64512499_64513555 0.13 RASGRP2
 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
 99
 0.95
chr1_240629057_240629208 0.13 FMN2
 formin 2
 8350
 0.21
chr19_8675123_8675468 0.13 ADAMTS10
 ADAM metallopeptidase with thrombospondin type 1 motif, 10
 290
 0.88
chr11_69851843_69851994 0.13 ANO1-AS2
 ANO1 antisense RNA 2 (head to head)
 69536
 0.09
chr16_23706248_23706462 0.13 ERN2
 endoplasmic reticulum to nucleus signaling 2
 274
 0.86
chr5_53810721_53810989 0.13 SNX18
 sorting nexin 18
 2734
 0.38
chr6_159235122_159235362 0.13 EZR-AS1
 EZR antisense RNA 1
 3801
 0.21
chr8_128957071_128957260 0.12 TMEM75
 transmembrane protein 75
 3426
 0.25
chr15_68872500_68872651 0.12 CORO2B
 coronin, actin binding protein, 2B
 1002
 0.69
chr7_152219742_152220164 0.12 ENSG00000199404
 .
 70223
 0.09
chr12_88917218_88917369 0.12 KITLG
 KIT ligand
 56945
 0.14
chr7_100032883_100033657 0.12 RP11-758P17.2
390
 0.45
chr11_114175854_114176005 0.12 NNMT
 nicotinamide N-methyltransferase
 7056
 0.22
chr11_36052910_36053061 0.12 ENSG00000263389
 .
 21337
 0.21
chr7_55545563_55545779 0.12 VOPP1
 vesicular, overexpressed in cancer, prosurvival protein 1
 38099
 0.19
chr20_13229977_13230206 0.12 RP5-1077I2.3
4075
 0.24
chr14_77370360_77370542 0.12 ENSG00000223174
 .
 13845
 0.2
chr19_3094656_3095580 0.12 GNA11
 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
 710
 0.53
chr17_39969274_39969651 0.12 FKBP10
 FK506 binding protein 10, 65 kDa
 279
 0.68
chr20_33871790_33873092 0.12 EIF6
 eukaryotic translation initiation factor 6
 77
 0.88
chr12_104973868_104974019 0.12 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 8683
 0.24
chr1_201915320_201915636 0.12 LMOD1
 leiomodin 1 (smooth muscle)
 237
 0.87
chr3_70881422_70881573 0.12 ENSG00000206939
 .
 23996
 0.24
chr8_6693007_6693158 0.12 DEFB1
 defensin, beta 1
 42462
 0.14
chr8_101117971_101118266 0.12 RGS22
 regulator of G-protein signaling 22
 72
 0.97
chr12_12016436_12016587 0.12 ETV6
 ets variant 6
 22360
 0.26
chr17_29036450_29037561 0.12 ENSG00000241631
 .
 7212
 0.17
chr8_93066568_93066719 0.12 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
 8548
 0.31
chr8_77585853_77586055 0.12 ZFHX4
 zinc finger homeobox 4
 7500
 0.24
chr6_20680738_20680889 0.12 RP3-348I23.2
120112
 0.06
chr16_73248437_73248618 0.12 C16orf47
 chromosome 16 open reading frame 47
 70181
 0.13
chr19_45754620_45755932 0.12 MARK4
 MAP/microtubule affinity-regulating kinase 4
 726
 0.57
chr9_18476160_18476529 0.12 ADAMTSL1
 ADAMTS-like 1
 2113
 0.45
chr8_119390030_119390181 0.12 AC023590.1
 Uncharacterized protein
 95624
 0.09
chr21_39720894_39721098 0.12 KCNJ15
 potassium inwardly-rectifying channel, subfamily J, member 15
 52148
 0.17
chr18_53537809_53537960 0.12 TCF4
 transcription factor 4
 205866
 0.03
chr15_49082630_49082781 0.11 RP11-485O10.2
7318
 0.18
chr1_101186979_101187209 0.11 VCAM1
 vascular cell adhesion molecule 1
 1774
 0.47
chr6_46458824_46459774 0.11 RCAN2
 regulator of calcineurin 2
 200
 0.78
chr12_57527559_57527864 0.11 STAT6
 signal transducer and activator of transcription 6, interleukin-4 induced
 1789
 0.2
chr6_106611529_106611909 0.11 RP1-134E15.3
63704
 0.11
chr19_14315927_14317134 0.11 LPHN1
 latrophilin 1
 451
 0.77
chr10_90711644_90712353 0.11 ACTA2
 actin, alpha 2, smooth muscle, aorta
 532
 0.73
chr15_101498489_101498640 0.11 LRRK1
 leucine-rich repeat kinase 1
 39014
 0.15
chr17_59361891_59362042 0.11 RP11-332H18.3
98180
 0.06
chr5_154033985_154034136 0.11 ENSG00000221552
 .
 31276
 0.14
chr9_99277013_99277426 0.11 CDC14B
 cell division cycle 14B
 51893
 0.13
chr9_132033008_132033468 0.11 ENSG00000220992
 .
 40242
 0.13
chr14_23000842_23001170 0.11 TRAJ15
 T cell receptor alpha joining 15
 2426
 0.17
chr1_25636296_25636447 0.11 TMEM50A
 transmembrane protein 50A
 28037
 0.11
chr11_3070813_3071033 0.11 ENSG00000201616
 .
 1172
 0.38
chr17_42637473_42637723 0.11 FZD2
 frizzled family receptor 2
 2673
 0.27
chr19_47732183_47732562 0.11 BBC3
 BCL2 binding component 3
 2079
 0.22
chr6_158653547_158654353 0.11 ENSG00000265803
 .
 57934
 0.11
chr2_121324572_121324723 0.11 ENSG00000201006
 .
 84202
 0.1
chr5_95768778_95768929 0.11 PCSK1
 proprotein convertase subtilisin/kexin type 1
 131
 0.98
chr22_20105332_20105991 0.11 RANBP1
 RAN binding protein 1
 185
 0.8
chr9_101137213_101137445 0.11 TBC1D2
 TBC1 domain family, member 2
 119414
 0.06
chr10_123276154_123276305 0.11 FGFR2
 fibroblast growth factor receptor 2
 1536
 0.55
chr13_24826013_24826241 0.11 SPATA13
 spermatogenesis associated 13
 271
 0.9
chr12_92270812_92270963 0.11 C12orf79
 chromosome 12 open reading frame 79
 259910
 0.02
chr12_124427345_124427647 0.11 CCDC92
 coiled-coil domain containing 92
 3824
 0.09
chr18_22868744_22868981 0.11 CTD-2006O16.2
13228
 0.28
chr12_31783207_31783359 0.11 METTL20
 methyltransferase like 20
 16811
 0.15
chr6_3340953_3341317 0.11 RP11-506K6.4
29239
 0.19
chr12_11916647_11916798 0.11 ETV6
 ets variant 6
 11287
 0.29
chr11_76382331_76382482 0.11 LRRC32
 leucine rich repeat containing 32
 615
 0.71
chr16_27256695_27256846 0.11 NSMCE1
 non-SMC element 1 homolog (S. cerevisiae)
 12371
 0.16
chr5_134178464_134178621 0.11 C5orf24
 chromosome 5 open reading frame 24
 2828
 0.25
chr12_93789120_93789411 0.11 NUDT4
 nudix (nucleoside diphosphate linked moiety X)-type motif 4
 16835
 0.14
chr11_19735768_19735975 0.11 NAV2
 neuron navigator 2
 728
 0.74
chr2_171362653_171362804 0.11 AC007277.3
137726
 0.05
chr6_143164322_143164558 0.11 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 6256
 0.3
chr1_161167282_161167469 0.11 ADAMTS4
 ADAM metallopeptidase with thrombospondin type 1 motif, 4
 1468
 0.16
chr11_114168512_114168913 0.11 NNMT
 nicotinamide N-methyltransferase
 106
 0.97
chr5_143407637_143407837 0.11 ENSG00000239390
 .
 112707
 0.07
chr18_18549206_18549357 0.11 ROCK1
 Rho-associated, coiled-coil containing protein kinase 1
 14450
 0.28
chr13_60709592_60709946 0.11 DIAPH3-AS2
 DIAPH3 antisense RNA 2
 9063
 0.22
chr11_123300349_123300500 0.10 AP000783.1
 Uncharacterized protein
 634
 0.77
chr11_1893200_1893351 0.10 LSP1
 lymphocyte-specific protein 1
 1159
 0.31
chr1_29308973_29309136 0.10 ENSG00000206704
 .
 3168
 0.29
chr11_2402201_2402352 0.10 CD81
 CD81 molecule
 1414
 0.26
chr15_48927305_48927456 0.10 FBN1
 fibrillin 1
 10538
 0.28
chr22_17671940_17672186 0.10 CECR1
 cat eye syndrome chromosome region, candidate 1
 8610
 0.17
chr5_34622373_34622524 0.10 RAI14
 retinoic acid induced 14
 33894
 0.19
chr21_36936389_36936667 0.10 ENSG00000211590
 .
 156485
 0.04
chr1_113087859_113088010 0.10 RP4-671G15.2
26871
 0.14
chr19_46148736_46148888 0.10 EML2
 echinoderm microtubule associated protein like 2
 75
 0.93
chr22_25346545_25346696 0.10 KIAA1671
 KIAA1671
 2077
 0.32
chr13_52158653_52159782 0.10 WDFY2
 WD repeat and FYVE domain containing 2
 573
 0.6
chr2_109202767_109202918 0.10 LIMS1
 LIM and senescent cell antigen-like domains 1
 1925
 0.4
chrX_54555990_54556466 0.10 GNL3L
 guanine nucleotide binding protein-like 3 (nucleolar)-like
 416
 0.88
chr16_87978942_87979129 0.10 BANP
 BTG3 associated nuclear protein
 5007
 0.21
chr4_169616116_169616373 0.10 ENSG00000206613
 .
 8377
 0.21
chr1_156215307_156216024 0.10 PAQR6
 progestin and adipoQ receptor family member VI
 2157
 0.16
chr14_101867418_101867569 0.10 ENSG00000258498
 .
 159266
 0.02
chr13_33850317_33850468 0.10 ENSG00000236581
 .
 1298
 0.49
chrY_7395772_7396011 0.10 ENSG00000252472
 .
 104692
 0.07
chr16_72955812_72956039 0.10 ENSG00000221799
 .
 62831
 0.11
chr13_36492055_36492221 0.10 DCLK1
 doublecortin-like kinase 1
 62359
 0.15
chr10_25971446_25971646 0.10 ENSG00000223019
 .
 131300
 0.05
chr14_99699001_99699256 0.10 AL109767.1
30157
 0.18
chr19_8656644_8657344 0.10 ADAMTS10
 ADAM metallopeptidase with thrombospondin type 1 motif, 10
 86
 0.96
chr2_231090060_231090211 0.10 SP110
 SP110 nuclear body protein
 309
 0.48
chr2_219646650_219647418 0.10 CYP27A1
 cytochrome P450, family 27, subfamily A, polypeptide 1
 555
 0.7
chr10_36739274_36739523 0.10 ENSG00000237002
 .
 11809
 0.29
chr20_32030739_32031661 0.10 SNTA1
 syntrophin, alpha 1
 498
 0.77
chr22_30641977_30642328 0.10 RP1-102K2.8
42
 0.9
chr1_36042987_36043882 0.10 RP4-728D4.2
104
 0.95
chr15_60688893_60689153 0.10 ANXA2
 annexin A2
 514
 0.85
chr1_78005375_78005526 0.10 AK5
 adenylate kinase 5
 7658
 0.25
chr15_65197450_65197821 0.10 ENSG00000264929
 .
 5197
 0.16
chr19_17445022_17445529 0.10 ANO8
 anoctamin 8
 363
 0.48
chr6_43214536_43215130 0.10 TTBK1
 tau tubulin kinase 1
 894
 0.48
chr10_124254663_124255115 0.10 HTRA1
 HtrA serine peptidase 1
 11318
 0.2
chr5_121416588_121416739 0.10 LOX
 lysyl oxidase
 2683
 0.32
chr6_36593181_36593356 0.10 ENSG00000263894
 .
 2979
 0.19
chr14_52346903_52347054 0.10 GNG2
 guanine nucleotide binding protein (G protein), gamma 2
 2668
 0.28
chr12_77309523_77309699 0.10 CSRP2
 cysteine and glycine-rich protein 2
 36771
 0.18
chr2_3497402_3497553 0.10 ADI1
 acireductone dioxygenase 1
 7110
 0.15
chr10_88162500_88162651 0.10 GRID1
 glutamate receptor, ionotropic, delta 1
 36340
 0.16
chr1_211589992_211590552 0.10 TRAF5
 TNF receptor-associated factor 5
 70566
 0.1
chr9_118919385_118919577 0.10 PAPPA
 pregnancy-associated plasma protein A, pappalysin 1
 3398
 0.32
chr7_27404330_27404615 0.10 EVX1-AS
 EVX1 antisense RNA
 117624
 0.04
chr22_41956802_41957044 0.10 CSDC2
 cold shock domain containing C2, RNA binding
 156
 0.93

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.0 0.0 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.1 GO:0007100 mitotic centrosome separation(GO:0007100)
0.0 0.1 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.1 GO:0071883 adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 0.1 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.1 GO:1903077 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0090281 negative regulation of calcium ion import(GO:0090281)
0.0 0.1 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.0 0.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.2 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.1 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.1 GO:0060033 anatomical structure regression(GO:0060033)
0.0 0.1 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0050932 regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0 0.1 GO:0008049 male courtship behavior(GO:0008049)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0048535 lymph node development(GO:0048535)
0.0 0.0 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.0 GO:1903054 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.0 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 0.1 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 0.0 GO:0071462 cellular response to water stimulus(GO:0071462)
0.0 0.0 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.0 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.0 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.0 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.0 GO:0009415 response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0 0.0 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.1 GO:0009886 post-embryonic morphogenesis(GO:0009886)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.0 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.0 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.0 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.0 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0072583 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.0 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.1 GO:0048241 epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242)
0.0 0.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0002507 tolerance induction(GO:0002507)
0.0 0.0 GO:0001779 natural killer cell differentiation(GO:0001779)
0.0 0.1 GO:0032288 myelin assembly(GO:0032288)
0.0 0.0 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.0 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.0 GO:0032656 regulation of interleukin-13 production(GO:0032656)
0.0 0.1 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.0 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.0 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0008347 glial cell migration(GO:0008347)
0.0 0.0 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0050655 dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.0 0.1 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.0 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.0 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.0 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0010830 regulation of myotube differentiation(GO:0010830)
0.0 0.0 GO:1901889 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.1 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0 0.1 GO:0090083 regulation of inclusion body assembly(GO:0090083)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.0 GO:0018995 host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0004954 prostanoid receptor activity(GO:0004954)
0.0 0.0 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.0 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.0 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.0 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.0 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.0 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.0 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.0 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.1 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.1 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor