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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for SOX1

Z-value: 0.98

Motif logo

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Transcription factors associated with SOX1

Gene Symbol Gene ID Gene Info
SOX1
ENSG00000182968.3 SRY-box transcription factor 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr13_112722136_112722317SOX13130.9242700.442.3e-01Click!
chr13_112720584_112720950SOX111460.580299-0.402.8e-01Click!
chr13_112797044_112797195SOX1752060.112819-0.245.4e-01Click!
chr13_112721079_112721230SOX17590.7296610.108.0e-01Click!
chr13_112770858_112771009SOX1490200.1667930.059.0e-01Click!

Activity of the SOX1 motif across conditions

Conditions sorted by the z-value of the SOX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_1772879_1773230 0.67 GNB1
 guanine nucleotide binding protein (G protein), beta polypeptide 1
 9330
 0.15
chr13_101046001_101046242 0.42 PCCA
 propionyl CoA carboxylase, alpha polypeptide
 25368
 0.23
chr10_60273912_60274168 0.42 BICC1
 bicaudal C homolog 1 (Drosophila)
 1140
 0.65
chr1_186072218_186072510 0.41 HMCN1
 hemicentin 1
 68155
 0.12
chr14_27065632_27065895 0.41 NOVA1
 neuro-oncological ventral antigen 1
 482
 0.74
chr4_75718841_75720131 0.40 BTC
 betacellulin
 410
 0.91
chr1_157964729_157965124 0.39 KIRREL
 kin of IRRE like (Drosophila)
 1491
 0.45
chr17_56744273_56744616 0.36 ENSG00000199426
 .
 386
 0.76
chr2_33360506_33360697 0.34 LTBP1
 latent transforming growth factor beta binding protein 1
 877
 0.73
chr11_46300696_46300847 0.33 CREB3L1
 cAMP responsive element binding protein 3-like 1
 1543
 0.37
chr6_85823864_85824548 0.33 NT5E
 5'-nucleotidase, ecto (CD73)
 335603
 0.01
chr4_127699042_127699253 0.33 ENSG00000199862
 .
 250227
 0.02
chr4_134068181_134068851 0.33 PCDH10
 protocadherin 10
 1954
 0.52
chr5_24644888_24645378 0.32 CDH10
 cadherin 10, type 2 (T2-cadherin)
 46
 0.99
chr22_29372984_29373407 0.32 ZNRF3
 zinc and ring finger 3
 9845
 0.17
chr11_71780711_71781020 0.31 NUMA1
 nuclear mitotic apparatus protein 1
 268
 0.8
chr9_40632604_40633916 0.30 SPATA31A3
 SPATA31 subfamily A, member 3
 67031
 0.14
chr8_107985745_107985896 0.30 ABRA
 actin-binding Rho activating protein
 203347
 0.03
chr4_113810751_113811050 0.30 RP11-119H12.6
7414
 0.26
chr15_30112674_30113382 0.29 TJP1
 tight junction protein 1
 723
 0.64
chr1_61332602_61332753 0.29 NFIA
 nuclear factor I/A
 1746
 0.51
chr2_33802935_33803086 0.29 AC020594.5
14396
 0.22
chr15_92404681_92404832 0.29 SLCO3A1
 solute carrier organic anion transporter family, member 3A1
 7405
 0.27
chr2_227658957_227659437 0.29 IRS1
 insulin receptor substrate 1
 5278
 0.23
chr8_104121485_104121788 0.28 KB-1639H6.4
11624
 0.13
chr5_32027565_32028229 0.28 ENSG00000266243
 .
 91632
 0.07
chr1_162603783_162603934 0.28 DDR2
 discoidin domain receptor tyrosine kinase 2
 1598
 0.41
chr9_65576390_65577630 0.27 SPATA31A7
 SPATA31 subfamily A, member 7
 67400
 0.15
chr5_127398296_127398447 0.27 SLC12A2
 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
 21087
 0.29
chr3_112354153_112354320 0.27 CCDC80
 coiled-coil domain containing 80
 2708
 0.34
chr2_55338658_55339041 0.27 RTN4
 reticulon 4
 908
 0.57
chr17_74442541_74443075 0.27 UBE2O
 ubiquitin-conjugating enzyme E2O
 6480
 0.12
chr3_104078695_104079148 0.27 ENSG00000265076
 .
 305281
 0.01
chr4_5749568_5749826 0.27 EVC
 Ellis van Creveld syndrome
 36755
 0.18
chr14_89020611_89020920 0.26 PTPN21
 protein tyrosine phosphatase, non-receptor type 21
 312
 0.86
chrX_139792263_139792666 0.26 LINC00632
 long intergenic non-protein coding RNA 632
 532
 0.82
chr13_25883872_25884023 0.26 NUPL1
 nucleoporin like 1
 1987
 0.33
chr14_31022770_31022975 0.26 G2E3
 G2/M-phase specific E3 ubiquitin protein ligase
 5457
 0.25
chr5_146887879_146888030 0.26 DPYSL3
 dihydropyrimidinase-like 3
 1665
 0.51
chr6_108971810_108972003 0.26 FOXO3
 forkhead box O3
 5643
 0.32
chr15_101783743_101783976 0.26 CHSY1
 chondroitin sulfate synthase 1
 8278
 0.18
chr6_102219183_102219334 0.26 GRIK2
 glutamate receptor, ionotropic, kainate 2
 46987
 0.21
chr2_229517064_229517215 0.26 ENSG00000251801
 .
 64550
 0.15
chr7_94029901_94030156 0.25 COL1A2
 collagen, type I, alpha 2
 6155
 0.29
chr3_61623550_61623701 0.25 PTPRG
 protein tyrosine phosphatase, receptor type, G
 76040
 0.12
chr12_72671108_72671475 0.25 ENSG00000236333
 .
 2604
 0.33
chr18_55671489_55671692 0.25 ENSG00000265200
 .
 12526
 0.24
chr1_240760211_240760638 0.24 RP11-467I20.6
6376
 0.21
chr21_17568279_17568430 0.24 ENSG00000201025
 .
 88735
 0.1
chr4_148693225_148693748 0.24 ENSG00000264274
 .
 10260
 0.18
chr1_170556453_170556642 0.24 RP11-576I22.2
54759
 0.13
chr15_99366541_99366815 0.24 ENSG00000264480
 .
 39023
 0.17
chr5_140863842_140863993 0.24 PCDHGC4
 protocadherin gamma subfamily C, 4
 824
 0.39
chr1_153584096_153584410 0.23 S100A16
 S100 calcium binding protein A16
 1306
 0.22
chr9_100181817_100181968 0.23 TDRD7
 tudor domain containing 7
 7516
 0.23
chr5_176783043_176783194 0.23 RGS14
 regulator of G-protein signaling 14
 1720
 0.2
chr2_216297601_216297993 0.23 FN1
 fibronectin 1
 2993
 0.27
chrX_53080432_53080669 0.23 GPR173
 G protein-coupled receptor 173
 2085
 0.31
chr4_170063887_170064038 0.23 RP11-327O17.2
58983
 0.13
chr7_18794470_18794725 0.23 ENSG00000222164
 .
 53305
 0.17
chr3_177333090_177333241 0.23 ENSG00000200288
 .
 9032
 0.31
chr15_75335743_75336025 0.23 PPCDC
 phosphopantothenoylcysteine decarboxylase
 268
 0.9
chr18_53089837_53090372 0.23 TCF4
 transcription factor 4
 361
 0.89
chr4_153272766_153273041 0.23 FBXW7
 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
 1220
 0.52
chr20_43645221_43645372 0.23 ENSG00000252021
 .
 12307
 0.16
chr20_19959113_19959531 0.22 NAA20
 N(alpha)-acetyltransferase 20, NatB catalytic subunit
 38438
 0.16
chr20_39944817_39945241 0.22 ZHX3
 zinc fingers and homeoboxes 3
 797
 0.64
chr15_57350079_57350487 0.22 ENSG00000222586
 .
 91688
 0.09
chr19_56118074_56118225 0.22 ZNF865
 zinc finger protein 865
 1378
 0.19
chr6_86113632_86113933 0.22 NT5E
 5'-nucleotidase, ecto (CD73)
 46027
 0.19
chr17_66706567_66706718 0.22 ENSG00000263690
 .
 56058
 0.14
chr12_42982187_42982354 0.22 PRICKLE1
 prickle homolog 1 (Drosophila)
 1208
 0.6
chr6_138867193_138867344 0.22 NHSL1
 NHS-like 1
 420
 0.9
chr6_27261362_27261571 0.22 POM121L2
 POM121 transmembrane nucleoporin-like 2
 17625
 0.19
chr8_116519428_116519579 0.22 AF178030.2
2326
 0.38
chr21_44496501_44497065 0.22 CBS
 cystathionine-beta-synthase
 270
 0.91
chr4_77508066_77508217 0.22 ENSG00000265314
 .
 11437
 0.17
chr2_145189034_145189185 0.22 ZEB2
 zinc finger E-box binding homeobox 2
 972
 0.69
chr5_96433895_96434046 0.22 CTD-2215E18.1
 Uncharacterized protein
 9191
 0.21
chr1_192780744_192780895 0.22 RGS2
 regulator of G-protein signaling 2, 24kDa
 2648
 0.37
chr2_36587826_36587983 0.22 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 4290
 0.35
chr1_119627265_119627416 0.22 WARS2-IT1
 WARS2 intronic transcript 1 (non-protein coding)
 37312
 0.16
chrX_139844529_139844680 0.22 CDR1
 cerebellar degeneration-related protein 1, 34kDa
 22119
 0.21
chr3_525379_525530 0.22 CHL1
 cell adhesion molecule L1-like
 94326
 0.09
chr20_61656853_61657255 0.22 BHLHE23
 basic helix-loop-helix family, member e23
 18667
 0.17
chr7_36301220_36301371 0.21 AC007327.5
30579
 0.15
chr14_42071339_42071490 0.21 LRFN5
 leucine rich repeat and fibronectin type III domain containing 5
 5359
 0.27
chr7_93465582_93465846 0.21 TFPI2
 tissue factor pathway inhibitor 2
 53768
 0.12
chr18_53537196_53537347 0.21 TCF4
 transcription factor 4
 205253
 0.03
chr1_26436861_26437012 0.21 PDIK1L
 PDLIM1 interacting kinase 1 like
 728
 0.54
chr6_56555605_56555856 0.21 DST
 dystonin
 47936
 0.18
chr5_100163193_100163344 0.21 ENSG00000221263
 .
 10999
 0.28
chr7_18125753_18126403 0.21 HDAC9
 histone deacetylase 9
 494
 0.84
chr1_200982094_200982245 0.21 KIF21B
 kinesin family member 21B
 10367
 0.19
chr19_44661345_44661496 0.21 ZNF226
 zinc finger protein 226
 7806
 0.12
chr8_116463339_116463609 0.21 TRPS1
 trichorhinophalangeal syndrome I
 40974
 0.2
chr1_36834692_36834843 0.21 STK40
 serine/threonine kinase 40
 7826
 0.13
chr13_36045598_36045825 0.21 MAB21L1
 mab-21-like 1 (C. elegans)
 5121
 0.22
chr8_24931073_24931224 0.21 ENSG00000241811
 .
 108087
 0.06
chr20_25506914_25507184 0.21 NINL
 ninein-like
 47386
 0.13
chr13_80912572_80913077 0.21 SPRY2
 sprouty homolog 2 (Drosophila)
 970
 0.67
chr2_200168941_200169130 0.21 RP11-486F17.1
20998
 0.26
chr1_114862373_114862591 0.21 TRIM33
 tripartite motif containing 33
 143376
 0.04
chr5_122452023_122452174 0.21 AC106786.1
26104
 0.15
chr20_17539236_17539459 0.21 BFSP1
 beaded filament structural protein 1, filensin
 136
 0.96
chr9_109624062_109624226 0.21 ZNF462
 zinc finger protein 462
 1234
 0.53
chr2_29751932_29752128 0.21 ENSG00000266310
 .
 25171
 0.26
chr8_97350778_97351015 0.20 ENSG00000199732
 .
 29346
 0.17
chr15_92722178_92722335 0.20 RP11-24J19.1
6590
 0.32
chr2_237653364_237653686 0.20 ACKR3
 atypical chemokine receptor 3
 175241
 0.03
chr4_187648163_187648374 0.20 FAT1
 FAT atypical cadherin 1
 392
 0.92
chr2_70151329_70151480 0.20 MXD1
 MAX dimerization protein 1
 9084
 0.12
chr9_100010529_100010680 0.20 CCDC180
 coiled-coil domain containing 180
 9825
 0.25
chr6_97663203_97663434 0.20 MMS22L
 MMS22-like, DNA repair protein
 47910
 0.19
chr6_121843994_121844420 0.20 ENSG00000201379
 .
 19565
 0.2
chr14_36560741_36560892 0.20 ENSG00000212071
 .
 104958
 0.07
chr10_32229562_32229783 0.20 ARHGAP12
 Rho GTPase activating protein 12
 11930
 0.24
chr5_167079523_167079674 0.20 CTB-78F1.1
7888
 0.28
chr5_84589012_84589394 0.20 ENSG00000215953
 .
 234749
 0.02
chr21_44499975_44500459 0.20 CBS
 cystathionine-beta-synthase
 3164
 0.22
chr14_75909783_75910034 0.20 JDP2
 Jun dimerization protein 2
 11071
 0.19
chr5_124536368_124536614 0.20 ENSG00000222107
 .
 150333
 0.05
chr7_157918330_157918481 0.20 AC011899.10
98340
 0.08
chr10_17074110_17074261 0.20 CUBN
 cubilin (intrinsic factor-cobalamin receptor)
 47991
 0.17
chr3_114137011_114137162 0.20 ZBTB20-AS1
 ZBTB20 antisense RNA 1
 30570
 0.18
chr5_39523911_39524062 0.19 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 61584
 0.15
chr2_196978205_196978455 0.19 RP11-347P5.1
37657
 0.15
chr9_82093653_82093804 0.19 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 92960
 0.1
chr16_11930217_11930382 0.19 RSL1D1
 ribosomal L1 domain containing 1
 14603
 0.12
chr16_84927762_84927913 0.19 ENSG00000265249
 .
 41263
 0.14
chrX_57933599_57933750 0.19 ZXDA
 zinc finger, X-linked, duplicated A
 3393
 0.4
chr17_2309940_2310157 0.19 MNT
 MAX network transcriptional repressor
 5636
 0.12
chr19_58055939_58056090 0.19 ZNF550
 zinc finger protein 550
 3347
 0.13
chr7_84121446_84121597 0.19 SEMA3A
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
 344
 0.94
chr4_139360491_139360642 0.19 SLC7A11
 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
 197063
 0.03
chr12_120697381_120697532 0.19 PXN
 paxillin
 6107
 0.13
chr1_35754106_35754533 0.19 ENSG00000240374
 .
 3780
 0.18
chr5_17743873_17744038 0.19 ENSG00000201715
 .
 398230
 0.01
chr1_61668583_61669016 0.19 RP4-802A10.1
78394
 0.11
chr5_124042484_124042635 0.19 RP11-436H11.2
21965
 0.13
chr3_156220748_156220899 0.19 RP11-305K5.1
21213
 0.21
chr5_41790406_41790557 0.19 OXCT1
 3-oxoacid CoA transferase 1
 4001
 0.32
chr12_81258392_81258564 0.19 LIN7A
 lin-7 homolog A (C. elegans)
 24649
 0.18
chr8_42712037_42712188 0.19 THAP1
 THAP domain containing, apoptosis associated protein 1
 13644
 0.14
chr7_116169535_116169759 0.19 CAV1
 caveolin 1, caveolae protein, 22kDa
 3300
 0.2
chrX_114851642_114851793 0.19 PLS3
 plastin 3
 7162
 0.23
chr4_47838472_47839750 0.19 CORIN
 corin, serine peptidase
 855
 0.65
chr19_1415408_1415673 0.19 CTB-25B13.13
1640
 0.16
chr2_200320961_200321297 0.19 SATB2
 SATB homeobox 2
 318
 0.86
chr9_43685064_43685767 0.19 CNTNAP3B
 contactin associated protein-like 3B
 505
 0.86
chr15_49916935_49917216 0.19 DTWD1
 DTW domain containing 1
 3779
 0.23
chr8_19148668_19149118 0.19 SH2D4A
 SH2 domain containing 4A
 22235
 0.28
chr3_106447792_106448185 0.19 ENSG00000200361
 .
 40463
 0.22
chr6_24858289_24858440 0.19 ENSG00000263391
 .
 18071
 0.17
chr1_202938451_202938746 0.19 CYB5R1
 cytochrome b5 reductase 1
 2190
 0.2
chr8_57086200_57086351 0.19 PLAG1
 pleiomorphic adenoma gene 1
 37563
 0.12
chr2_189839524_189839773 0.18 COL3A1
 collagen, type III, alpha 1
 549
 0.79
chr9_12859535_12860149 0.18 ENSG00000222658
 .
 25478
 0.2
chr7_19308836_19308987 0.18 FERD3L
 Fer3-like bHLH transcription factor
 123867
 0.05
chr12_76144948_76145099 0.18 ENSG00000264062
 .
 26702
 0.22
chr10_101952384_101952535 0.18 RP11-316M21.7
2666
 0.19
chr6_56507492_56507755 0.18 DST
 dystonin
 35
 0.99
chr15_33016455_33016606 0.18 GREM1
 gremlin 1, DAN family BMP antagonist
 6325
 0.22
chr15_96861717_96861868 0.18 NR2F2-AS1
 NR2F2 antisense RNA 1
 4082
 0.19
chr1_200121796_200121947 0.18 ENSG00000221403
 .
 7909
 0.28
chr7_115967399_115967904 0.18 AC073130.3
299
 0.91
chr1_65399507_65400011 0.18 JAK1
 Janus kinase 1
 32428
 0.2
chr2_8553463_8553614 0.18 AC011747.7
262358
 0.02
chr1_186970310_186970482 0.18 PLA2G4A
 phospholipase A2, group IVA (cytosolic, calcium-dependent)
 172274
 0.04
chr13_72377548_72377699 0.18 DACH1
 dachshund homolog 1 (Drosophila)
 63284
 0.15
chr8_64131982_64132133 0.18 ENSG00000241964
 .
 15412
 0.23
chr2_27010559_27010710 0.18 CENPA
 centromere protein A
 1698
 0.35
chr6_130554708_130554859 0.18 SAMD3
 sterile alpha motif domain containing 3
 10684
 0.28
chr5_124821676_124821827 0.18 ENSG00000222107
 .
 134927
 0.06
chr12_76144582_76144847 0.18 ENSG00000264062
 .
 26393
 0.22
chr1_81703498_81704139 0.18 ENSG00000223026
 .
 13656
 0.28
chr10_34686084_34686235 0.18 PARD3
 par-3 family cell polarity regulator
 24698
 0.28
chr6_46702576_46703631 0.18 PLA2G7
 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
 24
 0.97
chr14_52120103_52120254 0.18 FRMD6
 FERM domain containing 6
 1480
 0.42
chr9_126978620_126978771 0.18 NEK6
 NIMA-related kinase 6
 41190
 0.14
chr11_2972331_2972482 0.18 ENSG00000207008
 .
 12717
 0.12
chr2_66664825_66665240 0.18 MEIS1
 Meis homeobox 1
 93
 0.96
chr17_46634239_46634480 0.18 HOXB-AS2
 HOXB cluster antisense RNA 2
 265
 0.61
chr12_68915355_68915540 0.18 RAP1B
 RAP1B, member of RAS oncogene family
 89172
 0.08
chr5_159722948_159723245 0.18 ENSG00000243654
 .
 4301
 0.21
chr11_13204755_13204972 0.18 ARNTL
 aryl hydrocarbon receptor nuclear translocator-like
 93336
 0.09
chr17_75316367_75316959 0.18 SEPT9
 septin 9
 268
 0.93
chr8_121377938_121378124 0.18 COL14A1
 collagen, type XIV, alpha 1
 20346
 0.24
chr1_109934140_109934542 0.17 SORT1
 sortilin 1
 1638
 0.33
chr21_14607521_14607672 0.17 AL050302.1
 Uncharacterized protein
 137790
 0.05
chr8_56806111_56806262 0.17 RP11-318K15.2
32
 0.97
chr17_53799692_53799908 0.17 TMEM100
 transmembrane protein 100
 417
 0.89
chr8_37378833_37379079 0.17 RP11-150O12.6
4417
 0.31
chr22_28741040_28741191 0.17 ENSG00000199797
 .
 41373
 0.19
chr7_24988449_24988600 0.17 OSBPL3
 oxysterol binding protein-like 3
 30812
 0.21
chr15_35950174_35950564 0.17 DPH6
 diphthamine biosynthesis 6
 111976
 0.07
chr1_38317055_38317206 0.17 MTF1
 metal-regulatory transcription factor 1
 8162
 0.1
chr22_40578675_40578895 0.17 TNRC6B
 trinucleotide repeat containing 6B
 4839
 0.3
chr9_113598070_113598221 0.17 MUSK
 muscle, skeletal, receptor tyrosine kinase
 60518
 0.13
chr9_124329295_124329519 0.17 DAB2IP
 DAB2 interacting protein
 8
 0.98

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0006565 L-serine catabolic process(GO:0006565)
0.1 0.2 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.2 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.2 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.2 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.3 GO:0000090 mitotic anaphase(GO:0000090)
0.0 0.1 GO:0043931 ossification involved in bone maturation(GO:0043931)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.2 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0042023 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0070091 glucagon secretion(GO:0070091)
0.0 0.2 GO:0097435 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0 0.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.0 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.3 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.1 GO:0048875 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.0 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.0 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0001660 fever generation(GO:0001660)
0.0 0.0 GO:0019348 polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0 0.1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0 0.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.0 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.2 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0 0.0 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.0 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.0 GO:0046349 amino sugar biosynthetic process(GO:0046349)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.0 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0032431 activation of phospholipase A2 activity(GO:0032431)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.0 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.0 GO:0031501 mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.1 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001159 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1 0.2 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.1 GO:0004516 nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.0 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.0 GO:0004946 bombesin receptor activity(GO:0004946)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.0 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.0 GO:0043559 insulin binding(GO:0043559)
0.0 0.0 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.0 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.0 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.1 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.0 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.0 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.0 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.1 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated