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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SOX1

Z-value: 0.98

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Transcription factors associated with SOX1

Gene Symbol	Gene ID	Gene Info
SOX1 Ensembl NCBI GeneCards UniProt	ENSG00000182968.3	SOX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SOX1	chr13_112722136_112722317	313	0.924270	0.44	2.3e-01	Click!
SOX1	chr13_112720584_112720950	1146	0.580299	-0.40	2.8e-01	Click!
SOX1	chr13_112797044_112797195	75206	0.112819	-0.24	5.4e-01	Click!
SOX1	chr13_112721079_112721230	759	0.729661	0.10	8.0e-01	Click!
SOX1	chr13_112770858_112771009	49020	0.166793	0.05	9.0e-01	Click!

Activity of the SOX1 motif across conditions

Conditions sorted by the z-value of the SOX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_1772879_1773230	0.67	GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	9330	0.15
chr13_101046001_101046242	0.42	PCCA	propionyl CoA carboxylase, alpha polypeptide	25368	0.23
chr10_60273912_60274168	0.42	BICC1	bicaudal C homolog 1 (Drosophila)	1140	0.65
chr1_186072218_186072510	0.41	HMCN1	hemicentin 1	68155	0.12
chr14_27065632_27065895	0.41	NOVA1	neuro-oncological ventral antigen 1	482	0.74
chr4_75718841_75720131	0.40	BTC	betacellulin	410	0.91
chr1_157964729_157965124	0.39	KIRREL	kin of IRRE like (Drosophila)	1491	0.45
chr17_56744273_56744616	0.36	ENSG00000199426	.	386	0.76
chr2_33360506_33360697	0.34	LTBP1	latent transforming growth factor beta binding protein 1	877	0.73
chr11_46300696_46300847	0.33	CREB3L1	cAMP responsive element binding protein 3-like 1	1543	0.37
chr6_85823864_85824548	0.33	NT5E	5'-nucleotidase, ecto (CD73)	335603	0.01
chr4_127699042_127699253	0.33	ENSG00000199862	.	250227	0.02
chr4_134068181_134068851	0.33	PCDH10	protocadherin 10	1954	0.52
chr5_24644888_24645378	0.32	CDH10	cadherin 10, type 2 (T2-cadherin)	46	0.99
chr22_29372984_29373407	0.32	ZNRF3	zinc and ring finger 3	9845	0.17
chr11_71780711_71781020	0.31	NUMA1	nuclear mitotic apparatus protein 1	268	0.8
chr9_40632604_40633916	0.30	SPATA31A3	SPATA31 subfamily A, member 3	67031	0.14
chr8_107985745_107985896	0.30	ABRA	actin-binding Rho activating protein	203347	0.03
chr4_113810751_113811050	0.30	RP11-119H12.6		7414	0.26
chr15_30112674_30113382	0.29	TJP1	tight junction protein 1	723	0.64
chr1_61332602_61332753	0.29	NFIA	nuclear factor I/A	1746	0.51
chr2_33802935_33803086	0.29	AC020594.5		14396	0.22
chr15_92404681_92404832	0.29	SLCO3A1	solute carrier organic anion transporter family, member 3A1	7405	0.27
chr2_227658957_227659437	0.29	IRS1	insulin receptor substrate 1	5278	0.23
chr8_104121485_104121788	0.28	KB-1639H6.4		11624	0.13
chr5_32027565_32028229	0.28	ENSG00000266243	.	91632	0.07
chr1_162603783_162603934	0.28	DDR2	discoidin domain receptor tyrosine kinase 2	1598	0.41
chr9_65576390_65577630	0.27	SPATA31A7	SPATA31 subfamily A, member 7	67400	0.15
chr5_127398296_127398447	0.27	SLC12A2	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	21087	0.29
chr3_112354153_112354320	0.27	CCDC80	coiled-coil domain containing 80	2708	0.34
chr2_55338658_55339041	0.27	RTN4	reticulon 4	908	0.57
chr17_74442541_74443075	0.27	UBE2O	ubiquitin-conjugating enzyme E2O	6480	0.12
chr3_104078695_104079148	0.27	ENSG00000265076	.	305281	0.01
chr4_5749568_5749826	0.27	EVC	Ellis van Creveld syndrome	36755	0.18
chr14_89020611_89020920	0.26	PTPN21	protein tyrosine phosphatase, non-receptor type 21	312	0.86
chrX_139792263_139792666	0.26	LINC00632	long intergenic non-protein coding RNA 632	532	0.82
chr13_25883872_25884023	0.26	NUPL1	nucleoporin like 1	1987	0.33
chr14_31022770_31022975	0.26	G2E3	G2/M-phase specific E3 ubiquitin protein ligase	5457	0.25
chr5_146887879_146888030	0.26	DPYSL3	dihydropyrimidinase-like 3	1665	0.51
chr6_108971810_108972003	0.26	FOXO3	forkhead box O3	5643	0.32
chr15_101783743_101783976	0.26	CHSY1	chondroitin sulfate synthase 1	8278	0.18
chr6_102219183_102219334	0.26	GRIK2	glutamate receptor, ionotropic, kainate 2	46987	0.21
chr2_229517064_229517215	0.26	ENSG00000251801	.	64550	0.15
chr7_94029901_94030156	0.25	COL1A2	collagen, type I, alpha 2	6155	0.29
chr3_61623550_61623701	0.25	PTPRG	protein tyrosine phosphatase, receptor type, G	76040	0.12
chr12_72671108_72671475	0.25	ENSG00000236333	.	2604	0.33
chr18_55671489_55671692	0.25	ENSG00000265200	.	12526	0.24
chr1_240760211_240760638	0.24	RP11-467I20.6		6376	0.21
chr21_17568279_17568430	0.24	ENSG00000201025	.	88735	0.1
chr4_148693225_148693748	0.24	ENSG00000264274	.	10260	0.18
chr1_170556453_170556642	0.24	RP11-576I22.2		54759	0.13
chr15_99366541_99366815	0.24	ENSG00000264480	.	39023	0.17
chr5_140863842_140863993	0.24	PCDHGC4	protocadherin gamma subfamily C, 4	824	0.39
chr1_153584096_153584410	0.23	S100A16	S100 calcium binding protein A16	1306	0.22
chr9_100181817_100181968	0.23	TDRD7	tudor domain containing 7	7516	0.23
chr5_176783043_176783194	0.23	RGS14	regulator of G-protein signaling 14	1720	0.2
chr2_216297601_216297993	0.23	FN1	fibronectin 1	2993	0.27
chrX_53080432_53080669	0.23	GPR173	G protein-coupled receptor 173	2085	0.31
chr4_170063887_170064038	0.23	RP11-327O17.2		58983	0.13
chr7_18794470_18794725	0.23	ENSG00000222164	.	53305	0.17
chr3_177333090_177333241	0.23	ENSG00000200288	.	9032	0.31
chr15_75335743_75336025	0.23	PPCDC	phosphopantothenoylcysteine decarboxylase	268	0.9
chr18_53089837_53090372	0.23	TCF4	transcription factor 4	361	0.89
chr4_153272766_153273041	0.23	FBXW7	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	1220	0.52
chr20_43645221_43645372	0.23	ENSG00000252021	.	12307	0.16
chr20_19959113_19959531	0.22	NAA20	N(alpha)-acetyltransferase 20, NatB catalytic subunit	38438	0.16
chr20_39944817_39945241	0.22	ZHX3	zinc fingers and homeoboxes 3	797	0.64
chr15_57350079_57350487	0.22	ENSG00000222586	.	91688	0.09
chr19_56118074_56118225	0.22	ZNF865	zinc finger protein 865	1378	0.19
chr6_86113632_86113933	0.22	NT5E	5'-nucleotidase, ecto (CD73)	46027	0.19
chr17_66706567_66706718	0.22	ENSG00000263690	.	56058	0.14
chr12_42982187_42982354	0.22	PRICKLE1	prickle homolog 1 (Drosophila)	1208	0.6
chr6_138867193_138867344	0.22	NHSL1	NHS-like 1	420	0.9
chr6_27261362_27261571	0.22	POM121L2	POM121 transmembrane nucleoporin-like 2	17625	0.19
chr8_116519428_116519579	0.22	AF178030.2		2326	0.38
chr21_44496501_44497065	0.22	CBS	cystathionine-beta-synthase	270	0.91
chr4_77508066_77508217	0.22	ENSG00000265314	.	11437	0.17
chr2_145189034_145189185	0.22	ZEB2	zinc finger E-box binding homeobox 2	972	0.69
chr5_96433895_96434046	0.22	CTD-2215E18.1	Uncharacterized protein	9191	0.21
chr1_192780744_192780895	0.22	RGS2	regulator of G-protein signaling 2, 24kDa	2648	0.37
chr2_36587826_36587983	0.22	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	4290	0.35
chr1_119627265_119627416	0.22	WARS2-IT1	WARS2 intronic transcript 1 (non-protein coding)	37312	0.16
chrX_139844529_139844680	0.22	CDR1	cerebellar degeneration-related protein 1, 34kDa	22119	0.21
chr3_525379_525530	0.22	CHL1	cell adhesion molecule L1-like	94326	0.09
chr20_61656853_61657255	0.22	BHLHE23	basic helix-loop-helix family, member e23	18667	0.17
chr7_36301220_36301371	0.21	AC007327.5		30579	0.15
chr14_42071339_42071490	0.21	LRFN5	leucine rich repeat and fibronectin type III domain containing 5	5359	0.27
chr7_93465582_93465846	0.21	TFPI2	tissue factor pathway inhibitor 2	53768	0.12
chr18_53537196_53537347	0.21	TCF4	transcription factor 4	205253	0.03
chr1_26436861_26437012	0.21	PDIK1L	PDLIM1 interacting kinase 1 like	728	0.54
chr6_56555605_56555856	0.21	DST	dystonin	47936	0.18
chr5_100163193_100163344	0.21	ENSG00000221263	.	10999	0.28
chr7_18125753_18126403	0.21	HDAC9	histone deacetylase 9	494	0.84
chr1_200982094_200982245	0.21	KIF21B	kinesin family member 21B	10367	0.19
chr19_44661345_44661496	0.21	ZNF226	zinc finger protein 226	7806	0.12
chr8_116463339_116463609	0.21	TRPS1	trichorhinophalangeal syndrome I	40974	0.2
chr1_36834692_36834843	0.21	STK40	serine/threonine kinase 40	7826	0.13
chr13_36045598_36045825	0.21	MAB21L1	mab-21-like 1 (C. elegans)	5121	0.22
chr8_24931073_24931224	0.21	ENSG00000241811	.	108087	0.06
chr20_25506914_25507184	0.21	NINL	ninein-like	47386	0.13
chr13_80912572_80913077	0.21	SPRY2	sprouty homolog 2 (Drosophila)	970	0.67
chr2_200168941_200169130	0.21	RP11-486F17.1		20998	0.26
chr1_114862373_114862591	0.21	TRIM33	tripartite motif containing 33	143376	0.04
chr5_122452023_122452174	0.21	AC106786.1		26104	0.15
chr20_17539236_17539459	0.21	BFSP1	beaded filament structural protein 1, filensin	136	0.96
chr9_109624062_109624226	0.21	ZNF462	zinc finger protein 462	1234	0.53
chr2_29751932_29752128	0.21	ENSG00000266310	.	25171	0.26
chr8_97350778_97351015	0.20	ENSG00000199732	.	29346	0.17
chr15_92722178_92722335	0.20	RP11-24J19.1		6590	0.32
chr2_237653364_237653686	0.20	ACKR3	atypical chemokine receptor 3	175241	0.03
chr4_187648163_187648374	0.20	FAT1	FAT atypical cadherin 1	392	0.92
chr2_70151329_70151480	0.20	MXD1	MAX dimerization protein 1	9084	0.12
chr9_100010529_100010680	0.20	CCDC180	coiled-coil domain containing 180	9825	0.25
chr6_97663203_97663434	0.20	MMS22L	MMS22-like, DNA repair protein	47910	0.19
chr6_121843994_121844420	0.20	ENSG00000201379	.	19565	0.2
chr14_36560741_36560892	0.20	ENSG00000212071	.	104958	0.07
chr10_32229562_32229783	0.20	ARHGAP12	Rho GTPase activating protein 12	11930	0.24
chr5_167079523_167079674	0.20	CTB-78F1.1		7888	0.28
chr5_84589012_84589394	0.20	ENSG00000215953	.	234749	0.02
chr21_44499975_44500459	0.20	CBS	cystathionine-beta-synthase	3164	0.22
chr14_75909783_75910034	0.20	JDP2	Jun dimerization protein 2	11071	0.19
chr5_124536368_124536614	0.20	ENSG00000222107	.	150333	0.05
chr7_157918330_157918481	0.20	AC011899.10		98340	0.08
chr10_17074110_17074261	0.20	CUBN	cubilin (intrinsic factor-cobalamin receptor)	47991	0.17
chr3_114137011_114137162	0.20	ZBTB20-AS1	ZBTB20 antisense RNA 1	30570	0.18
chr5_39523911_39524062	0.19	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	61584	0.15
chr2_196978205_196978455	0.19	RP11-347P5.1		37657	0.15
chr9_82093653_82093804	0.19	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	92960	0.1
chr16_11930217_11930382	0.19	RSL1D1	ribosomal L1 domain containing 1	14603	0.12
chr16_84927762_84927913	0.19	ENSG00000265249	.	41263	0.14
chrX_57933599_57933750	0.19	ZXDA	zinc finger, X-linked, duplicated A	3393	0.4
chr17_2309940_2310157	0.19	MNT	MAX network transcriptional repressor	5636	0.12
chr19_58055939_58056090	0.19	ZNF550	zinc finger protein 550	3347	0.13
chr7_84121446_84121597	0.19	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	344	0.94
chr4_139360491_139360642	0.19	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	197063	0.03
chr12_120697381_120697532	0.19	PXN	paxillin	6107	0.13
chr1_35754106_35754533	0.19	ENSG00000240374	.	3780	0.18
chr5_17743873_17744038	0.19	ENSG00000201715	.	398230	0.01
chr1_61668583_61669016	0.19	RP4-802A10.1		78394	0.11
chr5_124042484_124042635	0.19	RP11-436H11.2		21965	0.13
chr3_156220748_156220899	0.19	RP11-305K5.1		21213	0.21
chr5_41790406_41790557	0.19	OXCT1	3-oxoacid CoA transferase 1	4001	0.32
chr12_81258392_81258564	0.19	LIN7A	lin-7 homolog A (C. elegans)	24649	0.18
chr8_42712037_42712188	0.19	THAP1	THAP domain containing, apoptosis associated protein 1	13644	0.14
chr7_116169535_116169759	0.19	CAV1	caveolin 1, caveolae protein, 22kDa	3300	0.2
chrX_114851642_114851793	0.19	PLS3	plastin 3	7162	0.23
chr4_47838472_47839750	0.19	CORIN	corin, serine peptidase	855	0.65
chr19_1415408_1415673	0.19	CTB-25B13.13		1640	0.16
chr2_200320961_200321297	0.19	SATB2	SATB homeobox 2	318	0.86
chr9_43685064_43685767	0.19	CNTNAP3B	contactin associated protein-like 3B	505	0.86
chr15_49916935_49917216	0.19	DTWD1	DTW domain containing 1	3779	0.23
chr8_19148668_19149118	0.19	SH2D4A	SH2 domain containing 4A	22235	0.28
chr3_106447792_106448185	0.19	ENSG00000200361	.	40463	0.22
chr6_24858289_24858440	0.19	ENSG00000263391	.	18071	0.17
chr1_202938451_202938746	0.19	CYB5R1	cytochrome b5 reductase 1	2190	0.2
chr8_57086200_57086351	0.19	PLAG1	pleiomorphic adenoma gene 1	37563	0.12
chr2_189839524_189839773	0.18	COL3A1	collagen, type III, alpha 1	549	0.79
chr9_12859535_12860149	0.18	ENSG00000222658	.	25478	0.2
chr7_19308836_19308987	0.18	FERD3L	Fer3-like bHLH transcription factor	123867	0.05
chr12_76144948_76145099	0.18	ENSG00000264062	.	26702	0.22
chr10_101952384_101952535	0.18	RP11-316M21.7		2666	0.19
chr6_56507492_56507755	0.18	DST	dystonin	35	0.99
chr15_33016455_33016606	0.18	GREM1	gremlin 1, DAN family BMP antagonist	6325	0.22
chr15_96861717_96861868	0.18	NR2F2-AS1	NR2F2 antisense RNA 1	4082	0.19
chr1_200121796_200121947	0.18	ENSG00000221403	.	7909	0.28
chr7_115967399_115967904	0.18	AC073130.3		299	0.91
chr1_65399507_65400011	0.18	JAK1	Janus kinase 1	32428	0.2
chr2_8553463_8553614	0.18	AC011747.7		262358	0.02
chr1_186970310_186970482	0.18	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	172274	0.04
chr13_72377548_72377699	0.18	DACH1	dachshund homolog 1 (Drosophila)	63284	0.15
chr8_64131982_64132133	0.18	ENSG00000241964	.	15412	0.23
chr2_27010559_27010710	0.18	CENPA	centromere protein A	1698	0.35
chr6_130554708_130554859	0.18	SAMD3	sterile alpha motif domain containing 3	10684	0.28
chr5_124821676_124821827	0.18	ENSG00000222107	.	134927	0.06
chr12_76144582_76144847	0.18	ENSG00000264062	.	26393	0.22
chr1_81703498_81704139	0.18	ENSG00000223026	.	13656	0.28
chr10_34686084_34686235	0.18	PARD3	par-3 family cell polarity regulator	24698	0.28
chr6_46702576_46703631	0.18	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	24	0.97
chr14_52120103_52120254	0.18	FRMD6	FERM domain containing 6	1480	0.42
chr9_126978620_126978771	0.18	NEK6	NIMA-related kinase 6	41190	0.14
chr11_2972331_2972482	0.18	ENSG00000207008	.	12717	0.12
chr2_66664825_66665240	0.18	MEIS1	Meis homeobox 1	93	0.96
chr17_46634239_46634480	0.18	HOXB-AS2	HOXB cluster antisense RNA 2	265	0.61
chr12_68915355_68915540	0.18	RAP1B	RAP1B, member of RAS oncogene family	89172	0.08
chr5_159722948_159723245	0.18	ENSG00000243654	.	4301	0.21
chr11_13204755_13204972	0.18	ARNTL	aryl hydrocarbon receptor nuclear translocator-like	93336	0.09
chr17_75316367_75316959	0.18	SEPT9	septin 9	268	0.93
chr8_121377938_121378124	0.18	COL14A1	collagen, type XIV, alpha 1	20346	0.24
chr1_109934140_109934542	0.17	SORT1	sortilin 1	1638	0.33
chr21_14607521_14607672	0.17	AL050302.1	Uncharacterized protein	137790	0.05
chr8_56806111_56806262	0.17	RP11-318K15.2		32	0.97
chr17_53799692_53799908	0.17	TMEM100	transmembrane protein 100	417	0.89
chr8_37378833_37379079	0.17	RP11-150O12.6		4417	0.31
chr22_28741040_28741191	0.17	ENSG00000199797	.	41373	0.19
chr7_24988449_24988600	0.17	OSBPL3	oxysterol binding protein-like 3	30812	0.21
chr15_35950174_35950564	0.17	DPH6	diphthamine biosynthesis 6	111976	0.07
chr1_38317055_38317206	0.17	MTF1	metal-regulatory transcription factor 1	8162	0.1
chr22_40578675_40578895	0.17	TNRC6B	trinucleotide repeat containing 6B	4839	0.3
chr9_113598070_113598221	0.17	MUSK	muscle, skeletal, receptor tyrosine kinase	60518	0.13
chr9_124329295_124329519	0.17	DAB2IP	DAB2 interacting protein	8	0.98

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0006565	L-serine catabolic process(GO:0006565)
0.1	0.2	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.2	GO:0070933	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.2	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.2	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.2	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.3	GO:0000090	mitotic anaphase(GO:0000090)
0.0	0.1	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.2	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.2	GO:0002076	osteoblast development(GO:0002076)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0070091	glucagon secretion(GO:0070091)
0.0	0.2	GO:0097435	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.2	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.0	GO:0010996	response to auditory stimulus(GO:0010996)
0.0	0.1	GO:0048240	sperm capacitation(GO:0048240)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0061687	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.3	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.1	GO:0048875	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.0	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0001660	fever generation(GO:0001660)
0.0	0.0	GO:0019348	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.1	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0	0.1	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.1	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.0	0.0	GO:0060605	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.2	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.0	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.0	GO:0045410	positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0	0.0	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.0	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0046349	amino sugar biosynthetic process(GO:0046349)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.1	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.0	GO:0060693	regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:0032431	activation of phospholipase A2 activity(GO:0032431)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.3	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.0	GO:0031501	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.1	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0	0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.1	GO:0002102	podosome(GO:0002102)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.3	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.2	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.2	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.1	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.2	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0070008	serine-type exopeptidase activity(GO:0070008)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.2	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.2	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.0	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.2	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.1	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0004000	adenosine deaminase activity(GO:0004000)
0.0	0.0	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.4	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.2	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated