Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SOX11

Z-value: 1.08

Motif logo

Transcription factors associated with SOX11

Gene Symbol	Gene ID	Gene Info
SOX11 Ensembl NCBI GeneCards UniProt	ENSG00000176887.5	SOX11

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SOX11	chr2_5837836_5837987	5112	0.215759	-0.51	1.6e-01	Click!
SOX11	chr2_5866291_5866487	33590	0.169456	-0.37	3.3e-01	Click!
SOX11	chr2_5835655_5835987	3022	0.248581	-0.31	4.2e-01	Click!
SOX11	chr2_5836055_5836258	3357	0.239357	-0.27	4.9e-01	Click!
SOX11	chr2_5866537_5866688	33813	0.169102	-0.25	5.1e-01	Click!

Activity of the SOX11 motif across conditions

Conditions sorted by the z-value of the SOX11 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_160876411_160876699	0.51	LPAL2	lipoprotein, Lp(a)-like 2, pseudogene	55484	0.15
chr12_91572648_91572799	0.30	DCN	decorin	394	0.91
chr18_66465806_66465957	0.29	CCDC102B	coiled-coil domain containing 102B	229	0.95
chr3_71678241_71678392	0.29	FOXP1	forkhead box P1	45176	0.15
chr3_178735001_178735152	0.28	ZMAT3	zinc finger, matrin-type 3	54278	0.14
chr9_115579394_115579717	0.27	SNX30	sorting nexin family member 30	21310	0.19
chr4_44915041_44915192	0.26	GNPDA2	glucosamine-6-phosphate deaminase 2	186504	0.03
chr5_42773072_42773223	0.26	CCDC152	coiled-coil domain containing 152	16227	0.2
chr1_82271501_82271652	0.26	LPHN2	latrophilin 2	5494	0.35
chr6_135043489_135043640	0.25	ALDH8A1	aldehyde dehydrogenase 8 family, member A1	206735	0.02
chr2_242318480_242318631	0.25	FARP2	FERM, RhoGEF and pleckstrin domain protein 2	6291	0.17
chr1_111212990_111213454	0.23	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	4433	0.21
chr7_43605292_43605443	0.23	ENSG00000252308	.	13120	0.18
chr15_58920203_58920354	0.23	ENSG00000239100	.	27844	0.16
chr4_81195528_81195918	0.23	FGF5	fibroblast growth factor 5	7930	0.26
chr18_10404815_10404966	0.22	ENSG00000239031	.	14893	0.25
chr12_3001234_3001385	0.22	TULP3	tubby like protein 3	1236	0.31
chr7_68830446_68830597	0.21	ENSG00000252423	.	35768	0.22
chr17_70372866_70373017	0.21	SOX9	SRY (sex determining region Y)-box 9	255780	0.02
chr5_148726870_148727055	0.21	GRPEL2	GrpE-like 2, mitochondrial (E. coli)	1897	0.22
chr2_44625797_44625948	0.21	CAMKMT	calmodulin-lysine N-methyltransferase	25991	0.2
chr3_82827750_82827901	0.21	NA	NA	> 10⁶	NA
chr13_74636535_74636686	0.21	KLF12	Kruppel-like factor 12	67424	0.15
chr11_4119066_4119217	0.21	RRM1	ribonucleotide reductase M1	3068	0.26
chr5_88169037_88169242	0.21	MEF2C	myocyte enhancer factor 2C	4655	0.27
chr5_156610422_156610951	0.21	ITK	IL2-inducible T-cell kinase	2849	0.18
chr15_49719079_49719362	0.21	FGF7	fibroblast growth factor 7	3763	0.28
chr12_104888025_104888586	0.21	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	37526	0.2
chrX_13680096_13680380	0.20	TCEANC	transcription elongation factor A (SII) N-terminal and central domain containing	6824	0.2
chr2_238777385_238777544	0.20	ENSG00000263723	.	1083	0.53
chr15_80361249_80361400	0.20	ZFAND6	zinc finger, AN1-type domain 6	3582	0.28
chr2_9736356_9736507	0.20	ENSG00000207086	.	18965	0.16
chr7_93924978_93925129	0.20	COL1A2	collagen, type I, alpha 2	98820	0.08
chr4_129759342_129759493	0.19	JADE1	jade family PHD finger 1	6829	0.31
chr3_16929685_16929836	0.19	PLCL2	phospholipase C-like 2	3308	0.33
chr1_170760279_170760430	0.19	PRRX1	paired related homeobox 1	127276	0.05
chr14_45711437_45711895	0.19	MIS18BP1	MIS18 binding protein 1	10714	0.2
chr4_144831533_144831721	0.19	GYPE	glycophorin E (MNS blood group)	4911	0.28
chr16_14282323_14282474	0.19	MKL2	MKL/myocardin-like 2	1626	0.41
chr2_231989300_231989451	0.19	HTR2B	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	457	0.79
chr1_172109829_172110023	0.19	ENSG00000207949	.	1879	0.31
chr10_95813054_95813205	0.19	ENSG00000252895	.	6247	0.2
chr12_91576386_91576586	0.19	DCN	decorin	0	0.99
chr2_134484497_134484648	0.19	ENSG00000200708	.	130910	0.05
chr1_115809994_115810145	0.18	RP4-663N10.1		15586	0.26
chr10_14630296_14630595	0.18	FAM107B	family with sequence similarity 107, member B	15943	0.22
chr8_17554451_17554629	0.18	MTUS1	microtubule associated tumor suppressor 1	639	0.69
chr15_58900274_58900425	0.18	ENSG00000239100	.	7915	0.2
chr7_15554887_15555236	0.18	AGMO	alkylglycerol monooxygenase	46579	0.2
chr7_80178912_80179063	0.18	GNAT3	guanine nucleotide binding protein, alpha transducing 3	37651	0.19
chr4_144832724_144832997	0.18	GYPE	glycophorin E (MNS blood group)	6144	0.27
chr14_45719805_45719966	0.18	MIS18BP1	MIS18 binding protein 1	2495	0.3
chr7_81915629_81915780	0.17	ENSG00000221262	.	3689	0.38
chr1_186248731_186248882	0.17	PRG4	proteoglycan 4	16599	0.19
chr6_107814031_107814182	0.17	SOBP	sine oculis binding protein homolog (Drosophila)	2944	0.28
chr11_76621964_76622115	0.17	ENSG00000212030	.	32763	0.15
chr7_90676285_90676436	0.17	FZD1	frizzled family receptor 1	217423	0.02
chr8_116676008_116676159	0.17	TRPS1	trichorhinophalangeal syndrome I	2178	0.48
chr4_90224084_90224235	0.17	GPRIN3	GPRIN family member 3	5002	0.34
chr2_118560616_118560767	0.17	AC009312.1		1059	0.57
chr6_138994650_138994868	0.17	RP11-390P2.4		18926	0.2
chr12_88966909_88967060	0.17	KITLG	KIT ligand	7254	0.25
chr6_81975145_81975342	0.17	RP1-300G12.2		269387	0.02
chr3_16938891_16939042	0.17	PLCL2	phospholipase C-like 2	12514	0.25
chr2_204328564_204328715	0.17	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	31437	0.21
chr4_81170515_81170725	0.17	FGF5	fibroblast growth factor 5	17133	0.22
chr6_42416461_42416719	0.17	TRERF1	transcriptional regulating factor 1	2409	0.31
chr5_121509459_121509610	0.17	CTC-441N14.1		17824	0.18
chr1_147013251_147013702	0.16	BCL9	B-cell CLL/lymphoma 9	294	0.94
chr17_67412035_67412186	0.16	MAP2K6	mitogen-activated protein kinase kinase 6	1271	0.56
chr15_71504545_71504696	0.16	RP11-673C5.2		23239	0.22
chrX_114276862_114277013	0.16	ENSG00000222122	.	9947	0.21
chr3_159628787_159629360	0.16	SCHIP1	schwannomin interacting protein 1	58345	0.11
chr11_116915783_116915934	0.16	ENSG00000200537	.	29245	0.13
chr3_60062649_60062918	0.16	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	105200	0.08
chr12_15283733_15283884	0.16	RERG	RAS-like, estrogen-regulated, growth inhibitor	7289	0.23
chr7_15722890_15723041	0.16	MEOX2	mesenchyme homeobox 2	3472	0.3
chr18_61647268_61647463	0.16	SERPINB8	serpin peptidase inhibitor, clade B (ovalbumin), member 8	323	0.9
chr4_158973077_158973228	0.16	FAM198B	family with sequence similarity 198, member B	107681	0.07
chr6_153321108_153321259	0.16	MTRF1L	mitochondrial translational release factor 1-like	2637	0.24
chr3_191008696_191008913	0.16	UTS2B	urotensin 2B	8612	0.23
chr4_135976985_135977136	0.16	ENSG00000207188	.	259617	0.02
chr7_19159987_19160138	0.16	AC003986.7		506	0.73
chr7_15600863_15601014	0.16	AGMO	alkylglycerol monooxygenase	702	0.8
chr6_134028778_134028929	0.16	RP3-323P13.2		59893	0.15
chr5_8686642_8686793	0.16	ENSG00000247516	.	225679	0.02
chr6_135518740_135518891	0.16	MYB-AS1	MYB antisense RNA 1	1682	0.35
chr6_37410804_37411085	0.16	CMTR1	cap methyltransferase 1	9948	0.21
chr13_80881448_80881599	0.16	SPRY2	sprouty homolog 2 (Drosophila)	32271	0.23
chr12_28543895_28544046	0.16	CCDC91	coiled-coil domain containing 91	59361	0.14
chr5_97761082_97761233	0.16	ENSG00000223053	.	213778	0.02
chr9_3732510_3732720	0.16	RP11-252M18.3		142969	0.05
chr13_74807691_74807851	0.16	ENSG00000206617	.	55580	0.16
chr11_109816867_109817064	0.16	ZC3H12C	zinc finger CCCH-type containing 12C	147122	0.05
chr17_46624038_46624312	0.16	HOXB-AS1	HOXB cluster antisense RNA 1	121	0.85
chr6_157297907_157298141	0.16	ARID1B	AT rich interactive domain 1B (SWI1-like)	75517	0.12
chr1_193506744_193506895	0.15	ENSG00000252241	.	194255	0.03
chr15_31120374_31120525	0.15	ENSG00000221379	.	26940	0.15
chr4_124597002_124597153	0.15	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	275954	0.02
chr11_63868915_63869066	0.15	FLRT1	fibronectin leucine rich transmembrane protein 1	1670	0.24
chr3_36504651_36504802	0.15	STAC	SH3 and cysteine rich domain	82661	0.11
chr7_13598952_13599103	0.15	ETV1	ets variant 1	427039	0.01
chr2_236525823_236525974	0.15	ENSG00000221704	.	45323	0.16
chr9_102829140_102829291	0.15	ERP44	endoplasmic reticulum protein 44	32107	0.16
chr15_25123597_25123815	0.15	ENSG00000238615	.	15188	0.12
chr2_20093347_20093498	0.15	TTC32	tetratricopeptide repeat domain 32	7980	0.25
chr18_32075255_32075406	0.15	DTNA	dystrobrevin, alpha	1463	0.59
chr2_144303459_144303649	0.15	RP11-570L15.2		26120	0.19
chr2_164202449_164202629	0.15	ENSG00000200902	.	57034	0.18
chr6_26066500_26066651	0.15	HIST1H1C	histone cluster 1, H1c	9876	0.07
chr11_9548903_9549060	0.15	ZNF143	zinc finger protein 143	14937	0.16
chr4_82426507_82426753	0.15	RASGEF1B	RasGEF domain family, member 1B	33561	0.24
chr10_53654836_53654987	0.15	PRKG1	protein kinase, cGMP-dependent, type I	151626	0.04
chr4_20447726_20447877	0.15	SLIT2-IT1	SLIT2 intronic transcript 1 (non-protein coding)	53989	0.15
chr7_33947519_33947670	0.15	BMPER	BMP binding endothelial regulator	2449	0.44
chr16_22383541_22383722	0.15	CDR2	cerebellar degeneration-related protein 2, 62kDa	2307	0.21
chr19_57684363_57684522	0.15	DUXA	double homeobox A	5631	0.13
chr8_66749078_66749602	0.15	PDE7A	phosphodiesterase 7A	1643	0.51
chr2_56142145_56142296	0.15	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	8136	0.21
chr6_85469897_85470069	0.15	TBX18	T-box 18	3090	0.38
chrX_135862199_135862350	0.15	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	1973	0.31
chr18_66917392_66917543	0.15	DOK6	docking protein 6	150824	0.04
chr12_22486636_22486842	0.15	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	358	0.93
chr1_200045067_200045218	0.15	ENSG00000252860	.	21953	0.18
chr13_41220599_41220750	0.15	FOXO1	forkhead box O1	20060	0.22
chr3_108542080_108542294	0.14	TRAT1	T cell receptor associated transmembrane adaptor 1	568	0.83
chr4_26325438_26325589	0.14	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	1021	0.7
chr3_16930113_16930264	0.14	PLCL2	phospholipase C-like 2	3736	0.32
chr5_102841576_102841727	0.14	NUDT12	nudix (nucleoside diphosphate linked moiety X)-type motif 12	56839	0.17
chr10_64252438_64252589	0.14	ZNF365	zinc finger protein 365	27694	0.24
chr12_27769583_27769734	0.14	PPFIBP1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	17377	0.2
chr4_154390309_154390666	0.14	KIAA0922	KIAA0922	2986	0.33
chrX_130965193_130965374	0.14	ENSG00000200587	.	107701	0.07
chr18_18949042_18949193	0.14	GREB1L	growth regulation by estrogen in breast cancer-like	5563	0.25
chr20_30973265_30973471	0.14	ASXL1	additional sex combs like 1 (Drosophila)	25818	0.17
chr7_62828662_62828813	0.14	AC006455.1		19498	0.21
chr2_177796950_177797101	0.14	ENSG00000206866	.	2207	0.44
chr7_35870864_35871015	0.14	SEPT7	septin 7	761	0.7
chr2_165658613_165658764	0.14	COBLL1	cordon-bleu WH2 repeat protein-like 1	28424	0.17
chr9_125660522_125660673	0.14	RC3H2	ring finger and CCCH-type domains 2	208	0.9
chr3_189887899_189888067	0.14	ENSG00000212489	.	4671	0.21
chr2_238317343_238317737	0.14	COL6A3	collagen, type VI, alpha 3	5251	0.23
chr2_189442201_189442352	0.14	GULP1	GULP, engulfment adaptor PTB domain containing 1	7466	0.32
chr8_100714756_100715301	0.14	ENSG00000243254	.	88722	0.08
chr6_152791599_152791750	0.14	SYNE1	spectrin repeat containing, nuclear envelope 1	2091	0.37
chr15_77352677_77352828	0.14	RP11-797A18.6		7915	0.19
chr3_130756724_130756875	0.14	NEK11	NIMA-related kinase 11	8246	0.16
chr2_65058589_65058850	0.14	ENSG00000199964	.	2572	0.27
chr10_123563818_123563969	0.14	ENSG00000201884	.	42222	0.17
chr4_41198899_41199050	0.14	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	17501	0.2
chr10_16535131_16535282	0.14	PTER	phosphotriesterase related	8875	0.2
chr1_78884908_78885243	0.14	ENSG00000212308	.	44122	0.17
chr12_13307421_13307712	0.14	EMP1	epithelial membrane protein 1	42084	0.15
chr10_24738869_24739102	0.14	KIAA1217	KIAA1217	623	0.8
chr6_16671315_16671488	0.14	RP1-151F17.1		89968	0.09
chr3_143568633_143568784	0.14	SLC9A9	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	1335	0.61
chr5_94891658_94891809	0.14	ARSK	arylsulfatase family, member K	862	0.43
chr21_37509990_37510141	0.14	CBR3	carbonyl reductase 3	2855	0.17
chr1_61559773_61559924	0.14	NFIA	nuclear factor I/A	5764	0.22
chr17_1297243_1297394	0.14	YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon	6157	0.19
chr3_59101698_59102091	0.14	C3orf67	chromosome 3 open reading frame 67	66084	0.15
chr2_109240388_109240570	0.14	LIMS1	LIM and senescent cell antigen-like domains 1	2757	0.33
chr15_102354727_102354878	0.14	OR4F15	olfactory receptor, family 4, subfamily F, member 15	3564	0.18
chr1_236766630_236766781	0.13	HEATR1	HEAT repeat containing 1	1083	0.54
chr5_8687066_8687217	0.13	ENSG00000247516	.	226103	0.02
chrY_22913829_22913980	0.13	RPS4Y2	ribosomal protein S4, Y-linked 2	4146	0.37
chr3_192575065_192575216	0.13	MB21D2	Mab-21 domain containing 2	60810	0.14
chr17_19807297_19807448	0.13	RP11-209D14.4		25678	0.15
chr5_130882612_130883040	0.13	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	14100	0.29
chr18_66093771_66093922	0.13	TMX3	thioredoxin-related transmembrane protein 3	288448	0.01
chr20_12205648_12205799	0.13	BTBD3	BTB (POZ) domain containing 3	306224	0.01
chr6_159230616_159230767	0.13	EZR-AS1	EZR antisense RNA 1	8352	0.18
chr7_94027064_94027257	0.13	COL1A2	collagen, type I, alpha 2	3287	0.35
chr15_49718765_49718970	0.13	FGF7	fibroblast growth factor 7	3410	0.29
chr6_26569237_26569542	0.13	ABT1	activator of basal transcription 1	27791	0.13
chr15_56760693_56760949	0.13	MNS1	meiosis-specific nuclear structural 1	3486	0.34
chr9_79450019_79450170	0.13	PCA3	prostate cancer antigen 3 (non-protein coding)	70742	0.11
chr18_53775687_53775874	0.13	ENSG00000201816	.	28955	0.27
chr1_178105985_178106136	0.13	RASAL2	RAS protein activator like 2	42784	0.21
chr10_52176430_52176581	0.13	AC069547.2	Uncharacterized protein	23739	0.19
chr2_66806799_66806950	0.13	MEIS1	Meis homeobox 1	70815	0.12
chr4_16219327_16219478	0.13	TAPT1	transmembrane anterior posterior transformation 1	8692	0.2
chr16_21657544_21657695	0.13	ENSG00000207042	.	4004	0.14
chr12_80707198_80707349	0.13	OTOGL	otogelin-like	23019	0.21
chr4_41198454_41198605	0.13	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	17946	0.19
chr5_88100959_88101110	0.13	MEF2C	myocyte enhancer factor 2C	18571	0.24
chr10_65175846_65175997	0.13	ENSG00000221063	.	43113	0.15
chrY_14900158_14900309	0.13	USP9Y	ubiquitin specific peptidase 9, Y-linked	58737	0.16
chr8_113941673_113941824	0.13	CSMD3	CUB and Sushi multiple domains 3	239477	0.02
chr3_22799861_22800012	0.13	UBE2E2-AS1	UBE2E2 antisense RNA 1 (head to head)	444088	0.01
chr5_124090679_124090914	0.13	ZNF608	zinc finger protein 608	6296	0.15
chr2_109102010_109102161	0.13	GCC2	GRIP and coiled-coil domain containing 2	13784	0.21
chr4_120135975_120136177	0.13	USP53	ubiquitin specific peptidase 53	2285	0.28
chr13_51485798_51485986	0.13	RNASEH2B-AS1	RNASEH2B antisense RNA 1	1044	0.49
chr2_160996867_160997018	0.13	ITGB6	integrin, beta 6	59821	0.14
chr1_8360871_8361022	0.13	ENSG00000251977	.	8623	0.16
chr5_116838988_116839139	0.13	SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	928433	0.0
chr15_56533191_56533342	0.13	RFX7	regulatory factor X, 7	2198	0.3
chr12_100957838_100957989	0.13	GAS2L3	growth arrest-specific 2 like 3	9548	0.24
chr1_165564678_165564829	0.12	RP11-280O1.2		13361	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX11

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.3	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.3	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.3	GO:0001757	somite specification(GO:0001757)
0.1	0.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.1	0.2	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.2	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0021825	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.3	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0002911	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.2	GO:0097435	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.1	GO:0045636	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.2	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:2000794	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.1	GO:0002857	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.0	GO:0006531	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.0	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0	0.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0051290	protein heterotetramerization(GO:0051290)
0.0	0.1	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.1	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0015853	adenine transport(GO:0015853)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.0	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.0	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.1	GO:0048240	sperm capacitation(GO:0048240)
0.0	0.0	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.2	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.0	GO:0051014	actin filament severing(GO:0051014)
0.0	0.0	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.0	GO:0002246	wound healing involved in inflammatory response(GO:0002246) inflammatory response to wounding(GO:0090594)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.0	GO:0048840	otolith development(GO:0048840)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0002347	response to tumor cell(GO:0002347)
0.0	0.0	GO:0030241	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0090244	Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0	0.0	GO:0090197	chemokine secretion(GO:0090195) regulation of chemokine secretion(GO:0090196) positive regulation of chemokine secretion(GO:0090197)
0.0	0.0	GO:0048293	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.1	GO:0060363	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.0	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0071875	adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.0	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.2	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0033087	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.0	GO:0060976	coronary vasculature development(GO:0060976)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.0	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.0	GO:0090399	replicative senescence(GO:0090399)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0003407	neural retina development(GO:0003407)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.2	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.1	GO:0043383	negative T cell selection(GO:0043383)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0032527	protein exit from endoplasmic reticulum(GO:0032527)
0.0	0.0	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.0	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0061043	vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0	0.0	GO:0002674	negative regulation of acute inflammatory response(GO:0002674)
0.0	0.1	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0	0.0	GO:0071028	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.0	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.0	GO:0002604	dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.0	GO:0010955	negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.5	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.2	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0033643	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.1	GO:0031083	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.1	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.8	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.2	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.2	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.2	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.2	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.2	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.2	GO:0030276	clathrin binding(GO:0030276)
0.0	0.0	GO:0070052	collagen V binding(GO:0070052)
0.0	0.0	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.0	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.0	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.0	GO:1990939	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.0	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.0	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0034739	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.0	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.0	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.0	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.0	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.0	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.0	0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.2	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.3	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.0	0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.0	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.0	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	0.5	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine