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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for SOX14

Z-value: 1.34

Motif logo

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Transcription factors associated with SOX14

Gene Symbol Gene ID Gene Info
SOX14
ENSG00000168875.1 SRY-box transcription factor 14

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr3_137490436_137490587SOX1469320.322540-0.826.8e-03Click!
chr3_137489915_137490161SOX1464590.3259380.501.8e-01Click!
chr3_137489277_137489428SOX1457730.3320390.472.0e-01Click!
chr3_137486919_137487668SOX1437140.3691420.472.0e-01Click!
chr3_137489599_137489750SOX1460950.328971-0.264.9e-01Click!

Activity of the SOX14 motif across conditions

Conditions sorted by the z-value of the SOX14 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_117512754_117513170 0.64 CTTNBP2
 cortactin binding protein 2
 599
 0.85
chr13_93879365_93880233 0.62 GPC6
 glypican 6
 704
 0.82
chr12_64239539_64239880 0.58 SRGAP1
 SLIT-ROBO Rho GTPase activating protein 1
 1168
 0.42
chr2_38303069_38303895 0.55 CYP1B1-AS1
 CYP1B1 antisense RNA 1
 156
 0.5
chr21_17442706_17442989 0.51 ENSG00000252273
 .
 35018
 0.24
chr10_30138566_30138997 0.50 SVIL
 supervillin
 114048
 0.06
chr12_27398836_27399341 0.48 STK38L
 serine/threonine kinase 38 like
 498
 0.86
chr1_162603392_162603656 0.48 DDR2
 discoidin domain receptor tyrosine kinase 2
 1264
 0.48
chr2_3223937_3224088 0.47 TSSC1-IT1
 TSSC1 intronic transcript 1 (non-protein coding)
 81224
 0.1
chr5_169407172_169407407 0.43 FAM196B
 family with sequence similarity 196, member B
 455
 0.87
chr2_159825200_159826543 0.43 TANC1
 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
 688
 0.73
chr22_46471692_46472277 0.42 FLJ27365
 hsa-mir-4763
 4208
 0.11
chr17_39861478_39861907 0.41 GAST
 gastrin
 6886
 0.1
chr4_184276450_184276660 0.41 ENSG00000238596
 .
 26104
 0.12
chr10_102110957_102111108 0.40 SCD
 stearoyl-CoA desaturase (delta-9-desaturase)
 4151
 0.16
chr5_174178214_174178699 0.39 ENSG00000266890
 .
 281
 0.94
chr10_95196659_95197038 0.39 MYOF
 myoferlin
 45103
 0.14
chr18_31157392_31158104 0.38 ASXL3
 additional sex combs like 3 (Drosophila)
 848
 0.76
chr15_92937263_92937484 0.38 ST8SIA2
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
 78
 0.98
chr3_114404388_114404544 0.38 ENSG00000264623
 .
 57906
 0.14
chr6_55956266_55956474 0.37 COL21A1
 collagen, type XXI, alpha 1
 13468
 0.31
chr8_71359441_71359951 0.37 ENSG00000253143
 .
 33026
 0.17
chr6_166074004_166074283 0.36 PDE10A
 phosphodiesterase 10A
 1414
 0.55
chr2_11990210_11990442 0.36 ENSG00000265172
 .
 13214
 0.21
chr2_51180015_51180298 0.36 ENSG00000272385
 .
 8227
 0.23
chr9_127024548_127024933 0.36 RP11-121A14.3
415
 0.67
chr7_93552832_93552983 0.35 GNG11
 guanine nucleotide binding protein (G protein), gamma 11
 1896
 0.3
chr17_42440424_42441259 0.35 FAM171A2
 family with sequence similarity 171, member A2
 402
 0.73
chr3_140329223_140329374 0.35 TRIM42
 tripartite motif containing 42
 67583
 0.12
chr13_45008185_45008336 0.35 TSC22D1
 TSC22 domain family, member 1
 2721
 0.38
chr6_150176715_150177267 0.34 RP11-350J20.12
3393
 0.15
chr17_39941723_39942672 0.34 JUP
 junction plakoglobin
 125
 0.93
chrX_102611721_102612532 0.34 WBP5
 WW domain binding protein 5
 746
 0.61
chr4_420426_420577 0.34 ENSG00000211482
 .
 16903
 0.16
chrX_10547580_10547808 0.34 MID1
 midline 1 (Opitz/BBB syndrome)
 2699
 0.31
chr4_141015619_141015856 0.34 RP11-392B6.1
33432
 0.2
chr5_133846660_133846957 0.33 ENSG00000240250
 .
 6693
 0.16
chr18_56244442_56244608 0.33 RP11-126O1.2
20223
 0.14
chr2_36704404_36704701 0.33 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 36281
 0.17
chr19_9517131_9518356 0.33 ZNF266
 zinc finger protein 266
 12014
 0.16
chr19_43025793_43025944 0.32 CEACAM1
 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
 6106
 0.18
chr10_73608410_73608759 0.32 PSAP
 prosaposin
 2498
 0.27
chr9_89952337_89952906 0.32 ENSG00000212421
 .
 77256
 0.11
chr19_34359259_34359976 0.32 ENSG00000240626
 .
 58913
 0.13
chr19_41195400_41196566 0.32 NUMBL
 numb homolog (Drosophila)-like
 44
 0.96
chr1_33812503_33812654 0.31 PHC2
 polyhomeotic homolog 2 (Drosophila)
 2908
 0.16
chr4_54459304_54459510 0.31 LNX1-AS2
 LNX1 antisense RNA 2
 255
 0.9
chr2_165924520_165924997 0.31 SCN3A
 sodium channel, voltage-gated, type III, alpha subunit
 25580
 0.2
chr7_112725821_112726406 0.31 GPR85
 G protein-coupled receptor 85
 280
 0.92
chr6_128812548_128813040 0.30 RP1-86D1.5
8878
 0.17
chr5_148786834_148787025 0.29 ENSG00000208035
 .
 21552
 0.11
chr6_160015485_160015820 0.29 SOD2
 superoxide dismutase 2, mitochondrial
 98608
 0.07
chr5_82768204_82768925 0.29 VCAN
 versican
 820
 0.75
chr6_72129322_72130506 0.29 ENSG00000207827
 .
 16590
 0.22
chr4_146403033_146403938 0.29 SMAD1
 SMAD family member 1
 153
 0.96
chr9_124888898_124889336 0.29 ENSG00000266583
 .
 6671
 0.17
chr17_13240957_13241216 0.29 ENSG00000266115
 .
 162559
 0.04
chr9_13278507_13279169 0.29 RP11-272P10.2
348
 0.67
chrX_38079311_38080259 0.29 SRPX
 sushi-repeat containing protein, X-linked
 367
 0.75
chr9_103113243_103113394 0.29 TEX10
 testis expressed 10
 1535
 0.45
chr13_38443188_38443573 0.28 TRPC4
 transient receptor potential cation channel, subfamily C, member 4
 480
 0.86
chr11_92361716_92361867 0.28 ENSG00000239086
 .
 100790
 0.08
chr4_139939633_139940037 0.28 ENSG00000264953
 .
 1102
 0.42
chr20_3386904_3388207 0.28 C20orf194
 chromosome 20 open reading frame 194
 717
 0.59
chr3_12879915_12880160 0.28 ENSG00000207496
 .
 1912
 0.22
chr4_140925773_140926068 0.27 MAML3
 mastermind-like 3 (Drosophila)
 113799
 0.06
chr1_61598470_61598652 0.27 RP4-802A10.1
8156
 0.25
chr5_105791072_105791223 0.27 ENSG00000252337
 .
 91219
 0.1
chr15_48894702_48894960 0.27 FBN1
 fibrillin 1
 43087
 0.18
chr4_146467680_146467914 0.27 SMAD1-AS1
 SMAD1 antisense RNA 1
 29527
 0.16
chr3_112358713_112358917 0.27 CCDC80
 coiled-coil domain containing 80
 1301
 0.54
chr11_122049732_122050124 0.27 ENSG00000207994
 .
 26912
 0.16
chr1_225839301_225840394 0.27 ENAH
 enabled homolog (Drosophila)
 571
 0.78
chr3_185482470_185482728 0.27 ENSG00000265470
 .
 3093
 0.3
chrX_102940107_102940387 0.26 MORF4L2
 mortality factor 4 like 2
 902
 0.43
chr5_14441548_14441780 0.26 TRIO
 trio Rho guanine nucleotide exchange factor
 46893
 0.19
chr20_1876393_1876635 0.26 SIRPA
 signal-regulatory protein alpha
 572
 0.81
chr12_54569137_54569288 0.26 RP11-834C11.8
12289
 0.11
chr13_41114829_41114980 0.26 AL133318.1
 Uncharacterized protein
 3581
 0.34
chr1_228277450_228277698 0.26 ARF1
 ADP-ribosylation factor 1
 6723
 0.12
chr2_216299709_216300678 0.26 FN1
 fibronectin 1
 597
 0.55
chr19_56989540_56990106 0.26 ZNF667
 zinc finger protein 667
 389
 0.8
chr2_5866291_5866487 0.25 SOX11
 SRY (sex determining region Y)-box 11
 33590
 0.17
chr4_77873265_77873416 0.25 SEPT11
 septin 11
 2325
 0.36
chr2_45834098_45834249 0.25 SRBD1
 S1 RNA binding domain 1
 4247
 0.26
chr1_120189851_120190681 0.25 ZNF697
 zinc finger protein 697
 130
 0.97
chr13_30250925_30251280 0.25 SLC7A1
 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
 81277
 0.11
chr12_133137038_133137885 0.25 P2RX2
 purinergic receptor P2X, ligand-gated ion channel, 2
 57905
 0.1
chr8_107067814_107067965 0.25 ENSG00000251003
 .
 4782
 0.34
chr1_31380173_31380807 0.25 SDC3
 syndecan 3
 1118
 0.44
chr6_123316934_123317301 0.25 CLVS2
 clavesin 2
 1
 0.99
chr11_131780761_131781452 0.25 NTM
 neurotrimin
 209
 0.95
chr2_122241860_122242011 0.25 CLASP1
 cytoplasmic linker associated protein 1
 5969
 0.24
chr3_134089254_134089458 0.25 AMOTL2
 angiomotin like 2
 1398
 0.47
chr2_71127433_71128165 0.25 VAX2
 ventral anterior homeobox 2
 79
 0.96
chr22_36232318_36232521 0.25 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 3846
 0.33
chr20_50063008_50063250 0.25 ENSG00000266761
 .
 6385
 0.28
chr2_106260790_106261225 0.24 NCK2
 NCK adaptor protein 2
 100347
 0.08
chr5_33936276_33936635 0.24 RXFP3
 relaxin/insulin-like family peptide receptor 3
 36
 0.98
chr15_92404681_92404832 0.24 SLCO3A1
 solute carrier organic anion transporter family, member 3A1
 7405
 0.27
chr15_68155525_68155920 0.24 ENSG00000206625
 .
 23339
 0.22
chr7_23507368_23507519 0.24 IGF2BP3
 insulin-like growth factor 2 mRNA binding protein 3
 2643
 0.24
chr4_141676823_141677280 0.24 TBC1D9
 TBC1 domain family, member 9 (with GRAM domain)
 223
 0.94
chr15_43659707_43659858 0.24 ZSCAN29
 zinc finger and SCAN domain containing 29
 2092
 0.19
chr5_155754238_155754771 0.24 SGCD
 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
 737
 0.81
chr2_109210392_109210708 0.24 LIMS1
 LIM and senescent cell antigen-like domains 1
 5628
 0.26
chr2_230135388_230135942 0.24 PID1
 phosphotyrosine interaction domain containing 1
 316
 0.93
chr4_124339787_124340099 0.24 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 18820
 0.3
chr4_128553582_128553997 0.24 INTU
 inturned planar cell polarity protein
 298
 0.94
chr5_73930304_73930586 0.24 HEXB
 hexosaminidase B (beta polypeptide)
 5403
 0.23
chr1_43672267_43672508 0.24 ENSG00000199240
 .
 10299
 0.15
chr10_6980964_6981115 0.24 PRKCQ
 protein kinase C, theta
 358776
 0.01
chr3_40821863_40822477 0.24 ZNF621
 zinc finger protein 621
 255263
 0.02
chr18_67888672_67888823 0.24 RTTN
 rotatin
 15566
 0.25
chr8_67454441_67454873 0.24 ENSG00000206949
 .
 41111
 0.13
chr4_187765674_187765940 0.24 ENSG00000252382
 .
 12803
 0.3
chr1_64240383_64241287 0.24 ROR1
 receptor tyrosine kinase-like orphan receptor 1
 1121
 0.63
chr1_200211795_200211974 0.23 ENSG00000221403
 .
 97922
 0.08
chr6_151392247_151392482 0.23 RP1-292B18.3
15171
 0.18
chr8_123580850_123581001 0.23 ENSG00000238901
 .
 102605
 0.08
chr3_160753082_160753543 0.23 B3GALNT1
 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
 65643
 0.12
chr13_103054295_103054752 0.23 FGF14
 fibroblast growth factor 14
 399
 0.89
chrX_70273312_70273567 0.23 SNX12
 sorting nexin 12
 14814
 0.12
chr15_95388341_95388759 0.23 MCTP2
 multiple C2 domains, transmembrane 2
 489347
 0.01
chr11_31006065_31006277 0.23 DCDC1
 doublecortin domain containing 1
 8062
 0.32
chr1_956379_957022 0.23 AGRN
 agrin
 1197
 0.27
chr5_67640604_67640808 0.23 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 52310
 0.18
chr13_98908140_98908291 0.23 RP11-573N10.1
22311
 0.17
chr15_73976688_73977423 0.23 CD276
 CD276 molecule
 17
 0.98
chr8_19148668_19149118 0.23 SH2D4A
 SH2 domain containing 4A
 22235
 0.28
chr13_110958781_110959436 0.23 COL4A1
 collagen, type IV, alpha 1
 370
 0.6
chr17_27567950_27568109 0.22 CRYBA1
 crystallin, beta A1
 5852
 0.19
chr6_94388930_94389081 0.22 ENSG00000252249
 .
 199819
 0.03
chr19_54483356_54483962 0.22 ENSG00000215998
 .
 1902
 0.19
chr15_99440572_99440803 0.22 RP11-654A16.1
3923
 0.25
chr6_84139999_84140706 0.22 ME1
 malic enzyme 1, NADP(+)-dependent, cytosolic
 412
 0.89
chr5_121407484_121407781 0.22 LOX
 lysyl oxidase
 6348
 0.25
chrX_110038687_110039773 0.22 CHRDL1
 chordin-like 1
 56
 0.99
chr6_76234416_76234599 0.22 FILIP1
 filamin A interacting protein 1
 31053
 0.15
chr3_115078299_115078524 0.22 ZBTB20
 zinc finger and BTB domain containing 20
 212293
 0.02
chr7_134893359_134893623 0.22 WDR91
 WD repeat domain 91
 2160
 0.24
chr11_123059250_123059539 0.22 CTD-2216M2.1
116
 0.97
chr15_91500342_91500803 0.22 RCCD1
 RCC1 domain containing 1
 1546
 0.18
chr9_112542645_112542955 0.22 AKAP2
 A kinase (PRKA) anchor protein 2
 31
 0.37
chr17_29359724_29359875 0.22 RP11-271K11.5
18245
 0.11
chr7_27156991_27157142 0.22 HOXA-AS2
 HOXA cluster antisense RNA 2
 1411
 0.18
chr5_77779952_77780244 0.22 LHFPL2
 lipoma HMGIC fusion partner-like 2
 64876
 0.13
chr1_15354372_15354671 0.22 KAZN
 kazrin, periplakin interacting protein
 82106
 0.1
chr9_116327712_116328152 0.22 RGS3
 regulator of G-protein signaling 3
 571
 0.8
chr1_23523630_23523879 0.22 HTR1D
 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
 2532
 0.23
chr15_52298712_52298863 0.22 MAPK6
 mitogen-activated protein kinase 6
 12611
 0.15
chr2_210444017_210444208 0.22 MAP2
 microtubule-associated protein 2
 33
 0.99
chrX_37208613_37209248 0.21 PRRG1
 proline rich Gla (G-carboxyglutamic acid) 1
 298
 0.54
chr15_37348939_37349090 0.21 ENSG00000206676
 .
 5883
 0.25
chr15_86018201_86018352 0.21 AKAP13
 A kinase (PRKA) anchor protein 13
 68995
 0.1
chr4_180517206_180517357 0.21 ENSG00000212191
 .
 910171
 0.0
chr13_107001311_107002028 0.21 EFNB2
 ephrin-B2
 185793
 0.03
chr4_145566489_145566777 0.21 HHIP-AS1
 HHIP antisense RNA 1
 431
 0.56
chr5_112602506_112602657 0.21 MCC
 mutated in colorectal cancers
 28065
 0.22
chr3_5699283_5699434 0.21 ENSG00000241227
 .
 404450
 0.01
chr8_94937293_94937444 0.21 PDP1
 pyruvate dehyrogenase phosphatase catalytic subunit 1
 5261
 0.21
chr1_206687074_206687508 0.21 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 6412
 0.15
chr19_58132756_58132907 0.21 ZNF134
 zinc finger protein 134
 7207
 0.1
chr6_53457738_53458227 0.21 GCLC
 glutamate-cysteine ligase, catalytic subunit
 23786
 0.17
chr16_1664599_1665551 0.21 CRAMP1L
 Crm, cramped-like (Drosophila)
 434
 0.69
chr15_71184312_71185443 0.21 LRRC49
 leucine rich repeat containing 49
 88
 0.55
chr6_79315946_79316109 0.21 IRAK1BP1
 interleukin-1 receptor-associated kinase 1 binding protein 1
 261162
 0.02
chr5_155109250_155109533 0.21 ENSG00000200275
 .
 163056
 0.04
chr17_53712756_53713118 0.21 ENSG00000200107
 .
 83766
 0.09
chr1_11751224_11751616 0.21 MAD2L2
 MAD2 mitotic arrest deficient-like 2 (yeast)
 114
 0.78
chr5_123986854_123987468 0.21 RP11-436H11.2
77363
 0.08
chr2_216296824_216297216 0.21 FN1
 fibronectin 1
 3770
 0.26
chr7_23513291_23513443 0.20 IGF2BP3
 insulin-like growth factor 2 mRNA binding protein 3
 3281
 0.22
chr4_77357055_77357299 0.20 SHROOM3
 shroom family member 3
 924
 0.54
chr13_113656029_113656238 0.20 MCF2L
 MCF.2 cell line derived transforming sequence-like
 65
 0.96
chr1_183846597_183846890 0.20 COLGALT2
 collagen beta(1-O)galactosyltransferase 2
 69009
 0.11
chr5_43308499_43308850 0.20 HMGCS1
 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
 4652
 0.23
chr2_208735056_208735207 0.20 AC083900.1
492
 0.83
chr14_73929626_73929971 0.20 ENSG00000251393
 .
 669
 0.64
chr1_157948474_157948783 0.20 KIRREL
 kin of IRRE like (Drosophila)
 14435
 0.21
chr17_59273533_59273731 0.20 RP11-136H19.1
60307
 0.12
chr7_92460547_92460704 0.20 CDK6
 cyclin-dependent kinase 6
 2606
 0.31
chr3_185533197_185533466 0.20 IGF2BP2
 insulin-like growth factor 2 mRNA binding protein 2
 5518
 0.25
chr18_65598172_65598323 0.20 DSEL
 dermatan sulfate epimerase-like
 414030
 0.01
chr4_154435359_154435510 0.20 KIAA0922
 KIAA0922
 41614
 0.18
chr7_20372086_20372237 0.20 CTA-293F17.1
791
 0.56
chrX_84499187_84500398 0.20 ZNF711
 zinc finger protein 711
 21
 0.94
chr13_37881211_37881446 0.20 ENSG00000202395
 .
 140533
 0.05
chr5_131561928_131562079 0.20 P4HA2
 prolyl 4-hydroxylase, alpha polypeptide II
 932
 0.55
chr9_37415208_37415514 0.20 GRHPR
 glyoxylate reductase/hydroxypyruvate reductase
 7302
 0.19
chrX_65857072_65857466 0.20 EDA2R
 ectodysplasin A2 receptor
 1614
 0.5
chr4_25458860_25459055 0.20 ANAPC4
 anaphase promoting complex subunit 4
 80015
 0.09
chr11_2959193_2959344 0.20 PHLDA2
 pleckstrin homology-like domain, family A, member 2
 8583
 0.12
chr20_35171113_35171392 0.20 MYL9
 myosin, light chain 9, regulatory
 1352
 0.35
chr4_183064315_183064489 0.20 AC108142.1
527
 0.65
chr17_28562165_28563406 0.20 SLC6A4
 solute carrier family 6 (neurotransmitter transporter), member 4
 69
 0.95
chr11_7599067_7599755 0.20 PPFIBP2
 PTPRF interacting protein, binding protein 2 (liprin beta 2)
 1140
 0.49
chr19_31714926_31715193 0.20 AC020952.1
 Uncharacterized protein
 74697
 0.12
chr10_76683945_76684144 0.20 KAT6B
 K(lysine) acetyltransferase 6B
 85586
 0.08
chr9_112402335_112402692 0.20 PALM2
 paralemmin 2
 555
 0.84

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.1 0.4 GO:0042686 negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.1 0.1 GO:0061364 regulation of negative chemotaxis(GO:0050923) apoptotic process involved in luteolysis(GO:0061364)
0.1 0.3 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 0.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.3 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.3 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.1 0.3 GO:0031053 primary miRNA processing(GO:0031053)
0.1 0.2 GO:0060058 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.1 0.2 GO:0061298 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1 0.3 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.3 GO:0021670 lateral ventricle development(GO:0021670)
0.1 0.2 GO:0009648 photoperiodism(GO:0009648)
0.1 0.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 0.2 GO:0021508 floor plate formation(GO:0021508)
0.1 0.2 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.1 0.1 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0010159 specification of organ position(GO:0010159)
0.0 0.3 GO:0060039 pericardium development(GO:0060039)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:0060536 trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0 0.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.2 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.3 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.3 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.2 GO:0021794 thalamus development(GO:0021794)
0.0 0.2 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.2 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.2 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.2 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.4 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.1 GO:0050942 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.1 GO:0060242 contact inhibition(GO:0060242)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.2 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0021892 cerebral cortex GABAergic interneuron differentiation(GO:0021892)
0.0 0.1 GO:1903170 negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0048343 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0 0.1 GO:0008049 male courtship behavior(GO:0008049)
0.0 0.1 GO:0097435 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0 0.1 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.2 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.0 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.0 GO:0032278 positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.1 GO:0003214 cardiac left ventricle morphogenesis(GO:0003214)
0.0 0.0 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.1 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.1 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.2 GO:0008347 glial cell migration(GO:0008347)
0.0 0.2 GO:0048048 embryonic eye morphogenesis(GO:0048048)
0.0 0.1 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.0 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.0 GO:1903960 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.2 GO:0031000 response to caffeine(GO:0031000)
0.0 0.1 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0050686 negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0008215 spermine metabolic process(GO:0008215)
0.0 0.0 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0071605 monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.1 GO:1903318 negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.0 0.0 GO:2000178 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.0 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.1 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.3 GO:0008038 neuron recognition(GO:0008038)
0.0 0.0 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.0 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0 0.0 GO:0060677 ureteric bud elongation(GO:0060677)
0.0 0.0 GO:0048319 axial mesoderm development(GO:0048318) axial mesoderm morphogenesis(GO:0048319)
0.0 0.0 GO:0032328 alanine transport(GO:0032328)
0.0 0.0 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.3 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.3 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.0 GO:0031223 auditory behavior(GO:0031223)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.2 GO:0046697 decidualization(GO:0046697)
0.0 0.0 GO:0060174 limb bud formation(GO:0060174)
0.0 0.0 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.0 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.0 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0 0.0 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.3 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.0 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.0 0.0 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.1 GO:0051931 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0 0.0 GO:0014824 tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0 0.0 GO:0021591 ventricular system development(GO:0021591)
0.0 0.1 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.1 GO:0001660 fever generation(GO:0001660)
0.0 0.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.0 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of calcium ion transmembrane transporter activity(GO:1901021) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341) positive regulation of cation channel activity(GO:2001259)
0.0 0.1 GO:0035329 hippo signaling(GO:0035329)
0.0 0.0 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.1 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.0 GO:0072162 mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.0 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0 0.0 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.1 GO:0043113 receptor clustering(GO:0043113)
0.0 0.0 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.0 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.0 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.4 GO:0060606 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0 0.1 GO:0021571 rhombomere 5 development(GO:0021571)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:0042554 superoxide anion generation(GO:0042554)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.0 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.0 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.0 0.0 GO:0051547 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0 0.1 GO:0035412 catenin import into nucleus(GO:0035411) regulation of catenin import into nucleus(GO:0035412)
0.0 0.1 GO:0042220 response to cocaine(GO:0042220)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.0 GO:0031650 regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652)
0.0 0.1 GO:0009223 pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.0 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.0 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.0 0.0 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.0 0.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.0 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.0 GO:0002686 negative regulation of leukocyte migration(GO:0002686)
0.0 0.2 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.0 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.0 GO:0070091 glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.0 0.0 GO:0035067 negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0 0.0 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0032344 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.0 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0 0.0 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.0 0.0 GO:0019348 polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0 0.1 GO:0015884 folic acid transport(GO:0015884)
0.0 0.0 GO:2000050 regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.0 GO:2000649 regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.3 GO:0070852 cell body fiber(GO:0070852)
0.1 0.4 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.2 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.3 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0001940 male pronucleus(GO:0001940)
0.0 0.3 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.0 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 0.0 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.0 GO:0070545 PeBoW complex(GO:0070545)
0.0 2.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.6 GO:0030426 growth cone(GO:0030426)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.3 GO:0004470 malic enzyme activity(GO:0004470)
0.1 0.2 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1 0.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.0 GO:0043394 proteoglycan binding(GO:0043394)
0.1 0.4 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.1 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.2 GO:0031545 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.2 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.1 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.3 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.2 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.3 GO:0030553 cGMP binding(GO:0030553)
0.0 0.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.0 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.6 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.0 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.1 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.0 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.0 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.0 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.0 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.3 GO:0050699 WW domain binding(GO:0050699)
0.0 0.0 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.0 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.1 GO:0019841 retinol binding(GO:0019841)
0.0 0.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.0 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.3 GO:0070330 aromatase activity(GO:0070330)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.0 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.0 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.0 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0008430 selenium binding(GO:0008430)
0.0 0.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.1 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.5 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.3 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.1 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.1 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.0 REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES Genes involved in MAPK targets/ Nuclear events mediated by MAP kinases
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.1 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols