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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SOX14

Z-value: 1.34

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Transcription factors associated with SOX14

Gene Symbol	Gene ID	Gene Info
SOX14 Ensembl NCBI GeneCards UniProt	ENSG00000168875.1	SOX14

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SOX14	chr3_137490436_137490587	6932	0.322540	-0.82	6.8e-03	Click!
SOX14	chr3_137489915_137490161	6459	0.325938	0.50	1.8e-01	Click!
SOX14	chr3_137489277_137489428	5773	0.332039	0.47	2.0e-01	Click!
SOX14	chr3_137486919_137487668	3714	0.369142	0.47	2.0e-01	Click!
SOX14	chr3_137489599_137489750	6095	0.328971	-0.26	4.9e-01	Click!

Activity of the SOX14 motif across conditions

Conditions sorted by the z-value of the SOX14 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_117512754_117513170	0.64	CTTNBP2	cortactin binding protein 2	599	0.85
chr13_93879365_93880233	0.62	GPC6	glypican 6	704	0.82
chr12_64239539_64239880	0.58	SRGAP1	SLIT-ROBO Rho GTPase activating protein 1	1168	0.42
chr2_38303069_38303895	0.55	CYP1B1-AS1	CYP1B1 antisense RNA 1	156	0.5
chr21_17442706_17442989	0.51	ENSG00000252273	.	35018	0.24
chr10_30138566_30138997	0.50	SVIL	supervillin	114048	0.06
chr12_27398836_27399341	0.48	STK38L	serine/threonine kinase 38 like	498	0.86
chr1_162603392_162603656	0.48	DDR2	discoidin domain receptor tyrosine kinase 2	1264	0.48
chr2_3223937_3224088	0.47	TSSC1-IT1	TSSC1 intronic transcript 1 (non-protein coding)	81224	0.1
chr5_169407172_169407407	0.43	FAM196B	family with sequence similarity 196, member B	455	0.87
chr2_159825200_159826543	0.43	TANC1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	688	0.73
chr22_46471692_46472277	0.42	FLJ27365	hsa-mir-4763	4208	0.11
chr17_39861478_39861907	0.41	GAST	gastrin	6886	0.1
chr4_184276450_184276660	0.41	ENSG00000238596	.	26104	0.12
chr10_102110957_102111108	0.40	SCD	stearoyl-CoA desaturase (delta-9-desaturase)	4151	0.16
chr5_174178214_174178699	0.39	ENSG00000266890	.	281	0.94
chr10_95196659_95197038	0.39	MYOF	myoferlin	45103	0.14
chr18_31157392_31158104	0.38	ASXL3	additional sex combs like 3 (Drosophila)	848	0.76
chr15_92937263_92937484	0.38	ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	78	0.98
chr3_114404388_114404544	0.38	ENSG00000264623	.	57906	0.14
chr6_55956266_55956474	0.37	COL21A1	collagen, type XXI, alpha 1	13468	0.31
chr8_71359441_71359951	0.37	ENSG00000253143	.	33026	0.17
chr6_166074004_166074283	0.36	PDE10A	phosphodiesterase 10A	1414	0.55
chr2_11990210_11990442	0.36	ENSG00000265172	.	13214	0.21
chr2_51180015_51180298	0.36	ENSG00000272385	.	8227	0.23
chr9_127024548_127024933	0.36	RP11-121A14.3		415	0.67
chr7_93552832_93552983	0.35	GNG11	guanine nucleotide binding protein (G protein), gamma 11	1896	0.3
chr17_42440424_42441259	0.35	FAM171A2	family with sequence similarity 171, member A2	402	0.73
chr3_140329223_140329374	0.35	TRIM42	tripartite motif containing 42	67583	0.12
chr13_45008185_45008336	0.35	TSC22D1	TSC22 domain family, member 1	2721	0.38
chr6_150176715_150177267	0.34	RP11-350J20.12		3393	0.15
chr17_39941723_39942672	0.34	JUP	junction plakoglobin	125	0.93
chrX_102611721_102612532	0.34	WBP5	WW domain binding protein 5	746	0.61
chr4_420426_420577	0.34	ENSG00000211482	.	16903	0.16
chrX_10547580_10547808	0.34	MID1	midline 1 (Opitz/BBB syndrome)	2699	0.31
chr4_141015619_141015856	0.34	RP11-392B6.1		33432	0.2
chr5_133846660_133846957	0.33	ENSG00000240250	.	6693	0.16
chr18_56244442_56244608	0.33	RP11-126O1.2		20223	0.14
chr2_36704404_36704701	0.33	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	36281	0.17
chr19_9517131_9518356	0.33	ZNF266	zinc finger protein 266	12014	0.16
chr19_43025793_43025944	0.32	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	6106	0.18
chr10_73608410_73608759	0.32	PSAP	prosaposin	2498	0.27
chr9_89952337_89952906	0.32	ENSG00000212421	.	77256	0.11
chr19_34359259_34359976	0.32	ENSG00000240626	.	58913	0.13
chr19_41195400_41196566	0.32	NUMBL	numb homolog (Drosophila)-like	44	0.96
chr1_33812503_33812654	0.31	PHC2	polyhomeotic homolog 2 (Drosophila)	2908	0.16
chr4_54459304_54459510	0.31	LNX1-AS2	LNX1 antisense RNA 2	255	0.9
chr2_165924520_165924997	0.31	SCN3A	sodium channel, voltage-gated, type III, alpha subunit	25580	0.2
chr7_112725821_112726406	0.31	GPR85	G protein-coupled receptor 85	280	0.92
chr6_128812548_128813040	0.30	RP1-86D1.5		8878	0.17
chr5_148786834_148787025	0.29	ENSG00000208035	.	21552	0.11
chr6_160015485_160015820	0.29	SOD2	superoxide dismutase 2, mitochondrial	98608	0.07
chr5_82768204_82768925	0.29	VCAN	versican	820	0.75
chr6_72129322_72130506	0.29	ENSG00000207827	.	16590	0.22
chr4_146403033_146403938	0.29	SMAD1	SMAD family member 1	153	0.96
chr9_124888898_124889336	0.29	ENSG00000266583	.	6671	0.17
chr17_13240957_13241216	0.29	ENSG00000266115	.	162559	0.04
chr9_13278507_13279169	0.29	RP11-272P10.2		348	0.67
chrX_38079311_38080259	0.29	SRPX	sushi-repeat containing protein, X-linked	367	0.75
chr9_103113243_103113394	0.29	TEX10	testis expressed 10	1535	0.45
chr13_38443188_38443573	0.28	TRPC4	transient receptor potential cation channel, subfamily C, member 4	480	0.86
chr11_92361716_92361867	0.28	ENSG00000239086	.	100790	0.08
chr4_139939633_139940037	0.28	ENSG00000264953	.	1102	0.42
chr20_3386904_3388207	0.28	C20orf194	chromosome 20 open reading frame 194	717	0.59
chr3_12879915_12880160	0.28	ENSG00000207496	.	1912	0.22
chr4_140925773_140926068	0.27	MAML3	mastermind-like 3 (Drosophila)	113799	0.06
chr1_61598470_61598652	0.27	RP4-802A10.1		8156	0.25
chr5_105791072_105791223	0.27	ENSG00000252337	.	91219	0.1
chr15_48894702_48894960	0.27	FBN1	fibrillin 1	43087	0.18
chr4_146467680_146467914	0.27	SMAD1-AS1	SMAD1 antisense RNA 1	29527	0.16
chr3_112358713_112358917	0.27	CCDC80	coiled-coil domain containing 80	1301	0.54
chr11_122049732_122050124	0.27	ENSG00000207994	.	26912	0.16
chr1_225839301_225840394	0.27	ENAH	enabled homolog (Drosophila)	571	0.78
chr3_185482470_185482728	0.27	ENSG00000265470	.	3093	0.3
chrX_102940107_102940387	0.26	MORF4L2	mortality factor 4 like 2	902	0.43
chr5_14441548_14441780	0.26	TRIO	trio Rho guanine nucleotide exchange factor	46893	0.19
chr20_1876393_1876635	0.26	SIRPA	signal-regulatory protein alpha	572	0.81
chr12_54569137_54569288	0.26	RP11-834C11.8		12289	0.11
chr13_41114829_41114980	0.26	AL133318.1	Uncharacterized protein	3581	0.34
chr1_228277450_228277698	0.26	ARF1	ADP-ribosylation factor 1	6723	0.12
chr2_216299709_216300678	0.26	FN1	fibronectin 1	597	0.55
chr19_56989540_56990106	0.26	ZNF667	zinc finger protein 667	389	0.8
chr2_5866291_5866487	0.25	SOX11	SRY (sex determining region Y)-box 11	33590	0.17
chr4_77873265_77873416	0.25	SEPT11	septin 11	2325	0.36
chr2_45834098_45834249	0.25	SRBD1	S1 RNA binding domain 1	4247	0.26
chr1_120189851_120190681	0.25	ZNF697	zinc finger protein 697	130	0.97
chr13_30250925_30251280	0.25	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	81277	0.11
chr12_133137038_133137885	0.25	P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	57905	0.1
chr8_107067814_107067965	0.25	ENSG00000251003	.	4782	0.34
chr1_31380173_31380807	0.25	SDC3	syndecan 3	1118	0.44
chr6_123316934_123317301	0.25	CLVS2	clavesin 2	1	0.99
chr11_131780761_131781452	0.25	NTM	neurotrimin	209	0.95
chr2_122241860_122242011	0.25	CLASP1	cytoplasmic linker associated protein 1	5969	0.24
chr3_134089254_134089458	0.25	AMOTL2	angiomotin like 2	1398	0.47
chr2_71127433_71128165	0.25	VAX2	ventral anterior homeobox 2	79	0.96
chr22_36232318_36232521	0.25	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	3846	0.33
chr20_50063008_50063250	0.25	ENSG00000266761	.	6385	0.28
chr2_106260790_106261225	0.24	NCK2	NCK adaptor protein 2	100347	0.08
chr5_33936276_33936635	0.24	RXFP3	relaxin/insulin-like family peptide receptor 3	36	0.98
chr15_92404681_92404832	0.24	SLCO3A1	solute carrier organic anion transporter family, member 3A1	7405	0.27
chr15_68155525_68155920	0.24	ENSG00000206625	.	23339	0.22
chr7_23507368_23507519	0.24	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3	2643	0.24
chr4_141676823_141677280	0.24	TBC1D9	TBC1 domain family, member 9 (with GRAM domain)	223	0.94
chr15_43659707_43659858	0.24	ZSCAN29	zinc finger and SCAN domain containing 29	2092	0.19
chr5_155754238_155754771	0.24	SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	737	0.81
chr2_109210392_109210708	0.24	LIMS1	LIM and senescent cell antigen-like domains 1	5628	0.26
chr2_230135388_230135942	0.24	PID1	phosphotyrosine interaction domain containing 1	316	0.93
chr4_124339787_124340099	0.24	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	18820	0.3
chr4_128553582_128553997	0.24	INTU	inturned planar cell polarity protein	298	0.94
chr5_73930304_73930586	0.24	HEXB	hexosaminidase B (beta polypeptide)	5403	0.23
chr1_43672267_43672508	0.24	ENSG00000199240	.	10299	0.15
chr10_6980964_6981115	0.24	PRKCQ	protein kinase C, theta	358776	0.01
chr3_40821863_40822477	0.24	ZNF621	zinc finger protein 621	255263	0.02
chr18_67888672_67888823	0.24	RTTN	rotatin	15566	0.25
chr8_67454441_67454873	0.24	ENSG00000206949	.	41111	0.13
chr4_187765674_187765940	0.24	ENSG00000252382	.	12803	0.3
chr1_64240383_64241287	0.24	ROR1	receptor tyrosine kinase-like orphan receptor 1	1121	0.63
chr1_200211795_200211974	0.23	ENSG00000221403	.	97922	0.08
chr6_151392247_151392482	0.23	RP1-292B18.3		15171	0.18
chr8_123580850_123581001	0.23	ENSG00000238901	.	102605	0.08
chr3_160753082_160753543	0.23	B3GALNT1	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	65643	0.12
chr13_103054295_103054752	0.23	FGF14	fibroblast growth factor 14	399	0.89
chrX_70273312_70273567	0.23	SNX12	sorting nexin 12	14814	0.12
chr15_95388341_95388759	0.23	MCTP2	multiple C2 domains, transmembrane 2	489347	0.01
chr11_31006065_31006277	0.23	DCDC1	doublecortin domain containing 1	8062	0.32
chr1_956379_957022	0.23	AGRN	agrin	1197	0.27
chr5_67640604_67640808	0.23	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	52310	0.18
chr13_98908140_98908291	0.23	RP11-573N10.1		22311	0.17
chr15_73976688_73977423	0.23	CD276	CD276 molecule	17	0.98
chr8_19148668_19149118	0.23	SH2D4A	SH2 domain containing 4A	22235	0.28
chr13_110958781_110959436	0.23	COL4A1	collagen, type IV, alpha 1	370	0.6
chr17_27567950_27568109	0.22	CRYBA1	crystallin, beta A1	5852	0.19
chr6_94388930_94389081	0.22	ENSG00000252249	.	199819	0.03
chr19_54483356_54483962	0.22	ENSG00000215998	.	1902	0.19
chr15_99440572_99440803	0.22	RP11-654A16.1		3923	0.25
chr6_84139999_84140706	0.22	ME1	malic enzyme 1, NADP(+)-dependent, cytosolic	412	0.89
chr5_121407484_121407781	0.22	LOX	lysyl oxidase	6348	0.25
chrX_110038687_110039773	0.22	CHRDL1	chordin-like 1	56	0.99
chr6_76234416_76234599	0.22	FILIP1	filamin A interacting protein 1	31053	0.15
chr3_115078299_115078524	0.22	ZBTB20	zinc finger and BTB domain containing 20	212293	0.02
chr7_134893359_134893623	0.22	WDR91	WD repeat domain 91	2160	0.24
chr11_123059250_123059539	0.22	CTD-2216M2.1		116	0.97
chr15_91500342_91500803	0.22	RCCD1	RCC1 domain containing 1	1546	0.18
chr9_112542645_112542955	0.22	AKAP2	A kinase (PRKA) anchor protein 2	31	0.37
chr17_29359724_29359875	0.22	RP11-271K11.5		18245	0.11
chr7_27156991_27157142	0.22	HOXA-AS2	HOXA cluster antisense RNA 2	1411	0.18
chr5_77779952_77780244	0.22	LHFPL2	lipoma HMGIC fusion partner-like 2	64876	0.13
chr1_15354372_15354671	0.22	KAZN	kazrin, periplakin interacting protein	82106	0.1
chr9_116327712_116328152	0.22	RGS3	regulator of G-protein signaling 3	571	0.8
chr1_23523630_23523879	0.22	HTR1D	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	2532	0.23
chr15_52298712_52298863	0.22	MAPK6	mitogen-activated protein kinase 6	12611	0.15
chr2_210444017_210444208	0.22	MAP2	microtubule-associated protein 2	33	0.99
chrX_37208613_37209248	0.21	PRRG1	proline rich Gla (G-carboxyglutamic acid) 1	298	0.54
chr15_37348939_37349090	0.21	ENSG00000206676	.	5883	0.25
chr15_86018201_86018352	0.21	AKAP13	A kinase (PRKA) anchor protein 13	68995	0.1
chr4_180517206_180517357	0.21	ENSG00000212191	.	910171	0.0
chr13_107001311_107002028	0.21	EFNB2	ephrin-B2	185793	0.03
chr4_145566489_145566777	0.21	HHIP-AS1	HHIP antisense RNA 1	431	0.56
chr5_112602506_112602657	0.21	MCC	mutated in colorectal cancers	28065	0.22
chr3_5699283_5699434	0.21	ENSG00000241227	.	404450	0.01
chr8_94937293_94937444	0.21	PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	5261	0.21
chr1_206687074_206687508	0.21	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	6412	0.15
chr19_58132756_58132907	0.21	ZNF134	zinc finger protein 134	7207	0.1
chr6_53457738_53458227	0.21	GCLC	glutamate-cysteine ligase, catalytic subunit	23786	0.17
chr16_1664599_1665551	0.21	CRAMP1L	Crm, cramped-like (Drosophila)	434	0.69
chr15_71184312_71185443	0.21	LRRC49	leucine rich repeat containing 49	88	0.55
chr6_79315946_79316109	0.21	IRAK1BP1	interleukin-1 receptor-associated kinase 1 binding protein 1	261162	0.02
chr5_155109250_155109533	0.21	ENSG00000200275	.	163056	0.04
chr17_53712756_53713118	0.21	ENSG00000200107	.	83766	0.09
chr1_11751224_11751616	0.21	MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	114	0.78
chr5_123986854_123987468	0.21	RP11-436H11.2		77363	0.08
chr2_216296824_216297216	0.21	FN1	fibronectin 1	3770	0.26
chr7_23513291_23513443	0.20	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3	3281	0.22
chr4_77357055_77357299	0.20	SHROOM3	shroom family member 3	924	0.54
chr13_113656029_113656238	0.20	MCF2L	MCF.2 cell line derived transforming sequence-like	65	0.96
chr1_183846597_183846890	0.20	COLGALT2	collagen beta(1-O)galactosyltransferase 2	69009	0.11
chr5_43308499_43308850	0.20	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	4652	0.23
chr2_208735056_208735207	0.20	AC083900.1		492	0.83
chr14_73929626_73929971	0.20	ENSG00000251393	.	669	0.64
chr1_157948474_157948783	0.20	KIRREL	kin of IRRE like (Drosophila)	14435	0.21
chr17_59273533_59273731	0.20	RP11-136H19.1		60307	0.12
chr7_92460547_92460704	0.20	CDK6	cyclin-dependent kinase 6	2606	0.31
chr3_185533197_185533466	0.20	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2	5518	0.25
chr18_65598172_65598323	0.20	DSEL	dermatan sulfate epimerase-like	414030	0.01
chr4_154435359_154435510	0.20	KIAA0922	KIAA0922	41614	0.18
chr7_20372086_20372237	0.20	CTA-293F17.1		791	0.56
chrX_84499187_84500398	0.20	ZNF711	zinc finger protein 711	21	0.94
chr13_37881211_37881446	0.20	ENSG00000202395	.	140533	0.05
chr5_131561928_131562079	0.20	P4HA2	prolyl 4-hydroxylase, alpha polypeptide II	932	0.55
chr9_37415208_37415514	0.20	GRHPR	glyoxylate reductase/hydroxypyruvate reductase	7302	0.19
chrX_65857072_65857466	0.20	EDA2R	ectodysplasin A2 receptor	1614	0.5
chr4_25458860_25459055	0.20	ANAPC4	anaphase promoting complex subunit 4	80015	0.09
chr11_2959193_2959344	0.20	PHLDA2	pleckstrin homology-like domain, family A, member 2	8583	0.12
chr20_35171113_35171392	0.20	MYL9	myosin, light chain 9, regulatory	1352	0.35
chr4_183064315_183064489	0.20	AC108142.1		527	0.65
chr17_28562165_28563406	0.20	SLC6A4	solute carrier family 6 (neurotransmitter transporter), member 4	69	0.95
chr11_7599067_7599755	0.20	PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)	1140	0.49
chr19_31714926_31715193	0.20	AC020952.1	Uncharacterized protein	74697	0.12
chr10_76683945_76684144	0.20	KAT6B	K(lysine) acetyltransferase 6B	85586	0.08
chr9_112402335_112402692	0.20	PALM2	paralemmin 2	555	0.84

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX14

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.1	0.4	GO:0042686	negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.1	0.1	GO:0061364	regulation of negative chemotaxis(GO:0050923) apoptotic process involved in luteolysis(GO:0061364)
0.1	0.3	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.1	0.2	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.1	0.3	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.1	0.3	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.1	0.3	GO:0031053	primary miRNA processing(GO:0031053)
0.1	0.2	GO:0060058	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.1	0.2	GO:0061298	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1	0.2	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1	0.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.3	GO:0021670	lateral ventricle development(GO:0021670)
0.1	0.2	GO:0009648	photoperiodism(GO:0009648)
0.1	0.2	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.2	GO:0021508	floor plate formation(GO:0021508)
0.1	0.2	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.1	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.3	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.2	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.0	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.2	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0010159	specification of organ position(GO:0010159)
0.0	0.3	GO:0060039	pericardium development(GO:0060039)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.2	GO:0008218	bioluminescence(GO:0008218)
0.0	0.2	GO:0060536	trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0	0.2	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.2	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.3	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.3	GO:0048703	embryonic viscerocranium morphogenesis(GO:0048703)
0.0	0.2	GO:0021794	thalamus development(GO:0021794)
0.0	0.2	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.2	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.3	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.3	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.2	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.3	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.3	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.5	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.1	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.0	0.4	GO:0070373	negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.3	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.1	GO:0050942	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.8	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.2	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0021892	cerebral cortex GABAergic interneuron differentiation(GO:0021892)
0.0	0.1	GO:1903170	negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0048343	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0097435	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.1	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.2	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.0	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.2	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.0	GO:0032278	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0003214	cardiac left ventricle morphogenesis(GO:0003214)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.2	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0	0.1	GO:0051968	positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.2	GO:0008347	glial cell migration(GO:0008347)
0.0	0.2	GO:0048048	embryonic eye morphogenesis(GO:0048048)
0.0	0.1	GO:0060736	prostate gland growth(GO:0060736)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.0	GO:1903960	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.2	GO:0031000	response to caffeine(GO:0031000)
0.0	0.1	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.1	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.1	GO:0050686	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0071605	monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:1903318	negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.0	0.0	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.0	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.1	GO:0002551	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.3	GO:0008038	neuron recognition(GO:0008038)
0.0	0.0	GO:0046475	glycerophospholipid catabolic process(GO:0046475)
0.0	0.0	GO:0010799	regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0	0.0	GO:0060677	ureteric bud elongation(GO:0060677)
0.0	0.0	GO:0048319	axial mesoderm development(GO:0048318) axial mesoderm morphogenesis(GO:0048319)
0.0	0.0	GO:0032328	alanine transport(GO:0032328)
0.0	0.0	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.0	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.3	GO:0033138	positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.3	GO:0048009	insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.0	GO:0031223	auditory behavior(GO:0031223)
0.0	0.1	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.2	GO:0046697	decidualization(GO:0046697)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.0	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.0	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.0	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0	0.0	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.3	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.1	GO:0051931	regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0	0.0	GO:0014824	tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0	0.0	GO:0021591	ventricular system development(GO:0021591)
0.0	0.1	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0001660	fever generation(GO:0001660)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.0	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of calcium ion transmembrane transporter activity(GO:1901021) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341) positive regulation of cation channel activity(GO:2001259)
0.0	0.1	GO:0035329	hippo signaling(GO:0035329)
0.0	0.0	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.0	0.0	GO:0072162	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0007019	microtubule depolymerization(GO:0007019)
0.0	0.0	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0043113	receptor clustering(GO:0043113)
0.0	0.0	GO:2000400	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.4	GO:0060606	neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0	0.1	GO:0021571	rhombomere 5 development(GO:0021571)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.2	GO:0042554	superoxide anion generation(GO:0042554)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.0	GO:0060251	regulation of glial cell proliferation(GO:0060251)
0.0	0.0	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.1	GO:0035412	catenin import into nucleus(GO:0035411) regulation of catenin import into nucleus(GO:0035412)
0.0	0.1	GO:0042220	response to cocaine(GO:0042220)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.0	GO:0031650	regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652)
0.0	0.1	GO:0009223	pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0	0.0	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0	0.0	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.0	0.0	GO:0034447	very-low-density lipoprotein particle clearance(GO:0034447)
0.0	0.0	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.0	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.0	GO:0002686	negative regulation of leukocyte migration(GO:0002686)
0.0	0.2	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.0	GO:0060134	prepulse inhibition(GO:0060134)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.0	GO:0070091	glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.0	0.0	GO:0035067	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.0	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0032344	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.0	GO:0090244	Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0	0.0	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.0	GO:0019348	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.1	GO:0015884	folic acid transport(GO:0015884)
0.0	0.0	GO:2000050	regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:2000649	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.3	GO:0070852	cell body fiber(GO:0070852)
0.1	0.4	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.3	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.3	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.2	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.3	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.3	GO:0043034	costamere(GO:0043034)
0.0	0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0005581	collagen trimer(GO:0005581)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.1	GO:0045277	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.2	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.0	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	1.0	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0	0.0	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.2	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.0	GO:0070545	PeBoW complex(GO:0070545)
0.0	2.8	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.6	GO:0030426	growth cone(GO:0030426)
0.0	0.1	GO:0030897	HOPS complex(GO:0030897)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.3	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.3	GO:0004470	malic enzyme activity(GO:0004470)
0.1	0.2	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1	0.3	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.1	0.4	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1	0.2	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.1	1.0	GO:0043394	proteoglycan binding(GO:0043394)
0.1	0.4	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.1	0.2	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.2	GO:0050682	AF-2 domain binding(GO:0050682)
0.1	0.2	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1	0.2	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1	0.3	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.1	0.2	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.1	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.2	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.3	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.2	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.3	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.2	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.2	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.2	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.2	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.3	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.3	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.2	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.3	GO:0030553	cGMP binding(GO:0030553)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.3	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.0	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.6	GO:0005518	collagen binding(GO:0005518)
0.0	0.1	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.4	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.4	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.0	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.1	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.0	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.0	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.2	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.3	GO:0050699	WW domain binding(GO:0050699)
0.0	0.0	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.2	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.0	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.0	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0004707	MAP kinase activity(GO:0004707)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.3	GO:0070330	aromatase activity(GO:0070330)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.0	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.0	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0004745	retinol dehydrogenase activity(GO:0004745)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.0	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.4	GO:0008307	structural constituent of muscle(GO:0008307)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.7	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.6	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.1	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	0.0	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.0	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.3	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.1	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	0.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	0.2	PID ALK1 PATHWAY	ALK1 signaling events
0.0	1.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.5	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.0	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	0.1	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.3	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0	0.1	PID NETRIN PATHWAY	Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.7	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.5	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.3	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.2	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.1	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	0.2	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	0.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.1	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.0	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.2	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.0	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.1	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.0	REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	Genes involved in MAPK targets/ Nuclear events mediated by MAP kinases
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.1	REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols