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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SOX17

Z-value: 1.62

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Transcription factors associated with SOX17

Gene Symbol	Gene ID	Gene Info
SOX17 Ensembl NCBI GeneCards UniProt	ENSG00000164736.5	SOX17

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SOX17	chr8_55379610_55379761	9190	0.261576	-0.61	8.4e-02	Click!
SOX17	chr8_55367217_55367368	3203	0.319968	-0.60	9.0e-02	Click!
SOX17	chr8_55379904_55380055	9484	0.260800	-0.21	5.8e-01	Click!
SOX17	chr8_55382631_55383060	12350	0.254611	-0.20	6.0e-01	Click!
SOX17	chr8_55379220_55379441	8835	0.262574	0.16	6.9e-01	Click!

Activity of the SOX17 motif across conditions

Conditions sorted by the z-value of the SOX17 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_39380930_39381081	0.65	ENSG00000206947	.	12272	0.23
chr1_246750885_246751091	0.63	RP11-439E19.1		18187	0.16
chr7_120630679_120630951	0.57	CPED1	cadherin-like and PC-esterase domain containing 1	1139	0.51
chr11_128099186_128099450	0.56	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	275971	0.01
chr4_181928306_181928668	0.56	ENSG00000251742	.	827774	0.0
chr8_101522130_101522303	0.51	KB-1615E4.3		17460	0.16
chr4_135119262_135119413	0.51	PABPC4L	poly(A) binding protein, cytoplasmic 4-like	3566	0.39
chr22_46454527_46455045	0.51	RP6-109B7.3		3991	0.12
chr9_21023989_21024197	0.47	PTPLAD2	protein tyrosine phosphatase-like A domain containing 2	7515	0.22
chr19_34359259_34359976	0.47	ENSG00000240626	.	58913	0.13
chr15_40812177_40812372	0.44	ENSG00000223313	.	9495	0.11
chr17_77817761_77818338	0.44	CBX4	chromobox homolog 4	4821	0.18
chr6_27205685_27206711	0.42	PRSS16	protease, serine, 16 (thymus)	9282	0.19
chr4_682374_683342	0.41	MFSD7	major facilitator superfamily domain containing 7	74	0.94
chr3_147127121_147127296	0.41	ZIC1	Zic family member 1	37	0.97
chr2_216299376_216299642	0.41	FN1	fibronectin 1	1281	0.4
chr2_19849364_19849515	0.41	TTC32	tetratricopeptide repeat domain 32	251963	0.02
chr7_41740779_41741576	0.41	INHBA	inhibin, beta A	970	0.56
chr7_15723235_15723386	0.40	MEOX2	mesenchyme homeobox 2	3127	0.32
chr16_4161991_4162273	0.40	ADCY9	adenylate cyclase 9	1895	0.4
chr2_161491624_161491775	0.40	RBMS1	RNA binding motif, single stranded interacting protein 1	141394	0.05
chr10_17273946_17274204	0.39	VIM	vimentin	1467	0.3
chr2_38303069_38303895	0.39	CYP1B1-AS1	CYP1B1 antisense RNA 1	156	0.5
chr13_24006860_24007105	0.39	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	859	0.74
chr10_29633011_29633162	0.38	LYZL1	lysozyme-like 1	55096	0.14
chr3_24527242_24527393	0.38	ENSG00000228791	.	8261	0.19
chr6_148829582_148830289	0.38	ENSG00000223322	.	15441	0.29
chr5_140698139_140698494	0.38	TAF7	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	2014	0.13
chr5_127981549_127981700	0.38	FBN2	fibrillin 2	13254	0.23
chr6_17924518_17924669	0.37	KIF13A	kinesin family member 13A	63101	0.13
chr1_65991038_65991651	0.37	RP4-630A11.3		39255	0.14
chr1_98623502_98623653	0.37	ENSG00000225206	.	111850	0.07
chr7_134469694_134469845	0.37	CALD1	caldesmon 1	5340	0.32
chr9_18476160_18476529	0.37	ADAMTSL1	ADAMTS-like 1	2113	0.45
chr15_37395216_37395447	0.36	MEIS2	Meis homeobox 2	1827	0.38
chr10_3336462_3336663	0.36	PITRM1	pitrilysin metallopeptidase 1	121559	0.06
chr7_43494536_43494714	0.36	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	24627	0.21
chr13_30740237_30740399	0.36	ENSG00000266816	.	40518	0.2
chr5_158176993_158177383	0.36	CTD-2363C16.1		232826	0.02
chr21_30504177_30504355	0.36	MAP3K7CL	MAP3K7 C-terminal like	688	0.61
chr12_111843881_111845308	0.36	SH2B3	SH2B adaptor protein 3	842	0.62
chr8_93115764_93116215	0.36	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	475	0.9
chr19_56332953_56333104	0.35	NLRP11	NLR family, pyrin domain containing 11	3425	0.16
chr16_73087072_73087516	0.35	ZFHX3	zinc finger homeobox 3	5020	0.25
chr5_151065179_151065606	0.35	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	601	0.67
chr9_129884150_129884930	0.35	ANGPTL2	angiopoietin-like 2	373	0.9
chr2_190043861_190044108	0.35	COL5A2	collagen, type V, alpha 2	621	0.79
chr1_200045338_200045520	0.35	ENSG00000252860	.	22240	0.18
chr4_145570819_145570970	0.35	HHIP	hedgehog interacting protein	3570	0.28
chr2_198539523_198539712	0.35	RFTN2	raftlin family member 2	1102	0.51
chr3_156793670_156793821	0.35	ENSG00000222499	.	58614	0.11
chrX_95691065_95691216	0.34	ENSG00000223260	.	25359	0.28
chr2_145261082_145261233	0.34	ZEB2	zinc finger E-box binding homeobox 2	13958	0.24
chr18_2856996_2857255	0.34	EMILIN2	elastin microfibril interfacer 2	10097	0.16
chr21_33893367_33893849	0.34	ENSG00000252045	.	17001	0.16
chr2_150982202_150982420	0.33	RND3	Rho family GTPase 3	359585	0.01
chr2_69480819_69481174	0.33	ENSG00000199460	.	70987	0.09
chr3_128207705_128209147	0.33	RP11-475N22.4		326	0.79
chr10_32096471_32096622	0.33	ARHGAP12	Rho GTPase activating protein 12	46562	0.16
chr10_29824157_29824642	0.33	ENSG00000207612	.	9627	0.19
chr14_56068035_56068254	0.33	KTN1	kinectin 1 (kinesin receptor)	366	0.89
chr3_157158697_157158863	0.33	PTX3	pentraxin 3, long	4202	0.3
chr18_5556544_5556701	0.33	ENSG00000252576	.	1650	0.33
chr4_86702209_86702472	0.33	ARHGAP24	Rho GTPase activating protein 24	2481	0.39
chr19_46167946_46168097	0.32	GIPR	gastric inhibitory polypeptide receptor	3481	0.1
chr8_85513931_85514082	0.32	ENSG00000206701	.	64094	0.14
chr15_96881050_96881298	0.32	ENSG00000222651	.	4684	0.17
chr1_200003972_200004421	0.32	NR5A2	nuclear receptor subfamily 5, group A, member 2	7185	0.18
chr1_101313202_101313363	0.32	EXTL2	exostosin-like glycosyltransferase 2	46938	0.12
chr4_119763070_119763221	0.32	SEC24D	SEC24 family member D	3320	0.33
chr12_19018320_19018530	0.32	CAPZA3	capping protein (actin filament) muscle Z-line, alpha 3	127380	0.05
chr2_32182398_32182549	0.32	MEMO1	mediator of cell motility 1	5894	0.21
chr6_106700141_106700423	0.32	ENSG00000244710	.	31304	0.17
chr8_117133093_117133257	0.32	ENSG00000221793	.	15823	0.28
chr11_76621964_76622115	0.32	ENSG00000212030	.	32763	0.15
chr10_25836306_25836457	0.31	ENSG00000222543	.	153608	0.04
chr16_86603613_86603777	0.31	RP11-463O9.5		2328	0.23
chr1_78960116_78960267	0.31	PTGFR	prostaglandin F receptor (FP)	3434	0.34
chr1_31500771_31500983	0.31	PUM1	pumilio RNA-binding family member 1	32926	0.16
chr4_18059479_18059630	0.31	LCORL	ligand dependent nuclear receptor corepressor-like	36055	0.23
chr2_205205743_205205894	0.31	PARD3B	par-3 family cell polarity regulator beta	204698	0.03
chr21_36780972_36781123	0.31	ENSG00000211590	.	311966	0.01
chr7_120631344_120631706	0.31	CPED1	cadherin-like and PC-esterase domain containing 1	1849	0.35
chr11_112505510_112505661	0.31	ENSG00000212397	.	32410	0.23
chr13_24007256_24007423	0.30	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	502	0.88
chr15_32963693_32963946	0.30	RP11-1000B6.2		1447	0.36
chr11_58350202_58350353	0.30	ZFP91	ZFP91 zinc finger protein	3693	0.18
chr1_120189851_120190681	0.30	ZNF697	zinc finger protein 697	130	0.97
chr3_65583100_65583492	0.30	MAGI1	membrane associated guanylate kinase, WW and PDZ domain containing 1	114	0.98
chr7_83821514_83821694	0.30	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	2613	0.45
chrX_39949292_39950247	0.30	BCOR	BCL6 corepressor	6887	0.33
chr14_53511502_53511653	0.30	RP11-368P15.3		8104	0.26
chr4_15922747_15922942	0.30	FGFBP1	fibroblast growth factor binding protein 1	17127	0.2
chr17_9862955_9863106	0.30	GAS7	growth arrest-specific 7	251	0.94
chr1_95561956_95562107	0.30	TMEM56	transmembrane protein 56	20863	0.12
chr12_13351879_13352395	0.30	EMP1	epithelial membrane protein 1	2417	0.37
chr3_25470358_25470509	0.29	RARB	retinoic acid receptor, beta	631	0.81
chr6_138864777_138865078	0.29	NHSL1	NHS-like 1	1921	0.45
chr17_8825496_8825647	0.29	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	9737	0.23
chr6_155214673_155214881	0.29	ENSG00000238963	.	11514	0.18
chr12_120246427_120246712	0.29	CIT	citron (rho-interacting, serine/threonine kinase 21)	5382	0.27
chr8_102372972_102373210	0.29	ENSG00000239211	.	37070	0.18
chr12_56100408_56100559	0.29	ITGA7	integrin, alpha 7	1002	0.31
chr6_76460588_76461018	0.29	MYO6	myosin VI	1754	0.36
chr3_21792365_21792565	0.29	ZNF385D	zinc finger protein 385D	462	0.89
chr2_12461385_12461536	0.29	ENSG00000207183	.	90167	0.09
chrX_100672866_100673966	0.29	ENSG00000221132	.	9067	0.11
chr6_168048486_168048637	0.29	AL009178.1	Uncharacterized protein; cDNA FLJ43200 fis, clone FEBRA2007793	147649	0.04
chr7_69470975_69471136	0.29	AUTS2	autism susceptibility candidate 2	406458	0.01
chr3_157160417_157160653	0.29	PTX3	pentraxin 3, long	5957	0.27
chr5_32505011_32505171	0.29	SUB1	SUB1 homolog (S. cerevisiae)	26648	0.2
chr10_126724055_126724287	0.29	ENSG00000264572	.	2732	0.29
chr5_70315966_70316295	0.29	NAIP	NLR family, apoptosis inhibitory protein	407	0.88
chr8_128651347_128651766	0.29	MYC	v-myc avian myelocytomatosis viral oncogene homolog	96124	0.08
chr8_83170035_83170244	0.29	SNX16	sorting nexin 16	415038	0.01
chr6_57369643_57369794	0.28	ENSG00000212017	.	114788	0.07
chr17_46671414_46671766	0.28	HOXB5	homeobox B5	267	0.75
chr12_13255888_13256039	0.28	GSG1	germ cell associated 1	613	0.76
chr7_18810301_18810537	0.28	ENSG00000222164	.	37483	0.22
chr10_95239818_95240064	0.28	MYOF	myoferlin	2010	0.32
chr6_81232911_81233062	0.28	BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	416603	0.01
chr18_9675042_9675193	0.28	RAB31	RAB31, member RAS oncogene family	33045	0.15
chr3_170147186_170147337	0.28	CLDN11	claudin 11	10406	0.26
chr12_84472792_84472943	0.28	ENSG00000221148	.	104360	0.09
chr15_96888963_96889465	0.28	ENSG00000222651	.	12724	0.15
chr3_149371362_149371801	0.28	WWTR1-AS1	WWTR1 antisense RNA 1	3226	0.2
chr2_74413202_74413353	0.28	CATX-2	HCG1989573; Uncharacterized protein	5240	0.14
chr2_54435704_54435855	0.28	ENSG00000252934	.	41635	0.15
chrX_53078746_53079004	0.28	GPR173	G protein-coupled receptor 173	410	0.85
chr3_32344642_32344793	0.28	ENSG00000207857	.	43497	0.14
chr10_3666400_3666551	0.28	RP11-184A2.3		126784	0.06
chr10_63818920_63819071	0.28	ARID5B	AT rich interactive domain 5B (MRF1-like)	10025	0.27
chr6_117920563_117920770	0.28	GOPC	golgi-associated PDZ and coiled-coil motif containing	2861	0.34
chr6_3825964_3826270	0.28	RP11-420L9.4		6050	0.22
chr21_33867197_33867430	0.28	ENSG00000252045	.	43296	0.11
chr8_116675050_116675578	0.27	TRPS1	trichorhinophalangeal syndrome I	1409	0.6
chr10_89822354_89822505	0.27	ENSG00000200891	.	67977	0.12
chr7_92327286_92327437	0.27	ENSG00000206763	.	3767	0.31
chr15_56035451_56035609	0.27	PRTG	protogenin	242	0.94
chr4_48256193_48256344	0.27	TEC	tec protein tyrosine kinase	15613	0.23
chr13_76213824_76214088	0.27	LMO7	LIM domain 7	3497	0.21
chr7_55001398_55001578	0.27	ENSG00000252054	.	67977	0.12
chr5_135365829_135365985	0.27	TGFBI	transforming growth factor, beta-induced, 68kDa	1216	0.52
chr5_74862582_74862812	0.27	POLK	polymerase (DNA directed) kappa	19849	0.15
chr12_960802_961189	0.27	WNK1	WNK lysine deficient protein kinase 1	136	0.97
chr14_73881950_73882101	0.27	NUMB	numb homolog (Drosophila)	5246	0.21
chr8_94238484_94238635	0.27	AC016885.1	Uncharacterized protein	3308	0.29
chr12_78336292_78336638	0.27	NAV3	neuron navigator 3	23591	0.28
chr12_29397730_29397881	0.27	FAR2	fatty acyl CoA reductase 2	21127	0.23
chr6_11219192_11219343	0.27	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	13624	0.22
chr11_63647826_63647977	0.27	ENSG00000202089	.	2256	0.22
chr6_46900604_46900792	0.27	GPR116	G protein-coupled receptor 116	10984	0.22
chr5_172195314_172195493	0.27	DUSP1	dual specificity phosphatase 1	2795	0.19
chr17_46177753_46179071	0.27	CBX1	chromobox homolog 1	148	0.91
chr11_10479478_10479629	0.27	AMPD3	adenosine monophosphate deaminase 3	1820	0.36
chr5_158128189_158128340	0.26	CTD-2363C16.1		281750	0.01
chr1_186944219_186944581	0.26	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	146278	0.05
chr12_54017495_54017675	0.26	ATF7	activating transcription factor 7	2170	0.23
chr9_74295565_74295716	0.26	TMEM2	transmembrane protein 2	24208	0.27
chr6_18551314_18551465	0.26	ENSG00000207775	.	20626	0.27
chr12_80987527_80987740	0.26	RP11-272K23.3		153	0.97
chr4_186577993_186578477	0.26	SORBS2	sorbin and SH3 domain containing 2	112	0.97
chr1_22345507_22345745	0.26	ENSG00000201273	.	8148	0.1
chr6_76504796_76504947	0.26	MYO6	myosin VI	22369	0.17
chr5_60962215_60962366	0.26	ENSG00000212215	.	2224	0.32
chr3_1098193_1098344	0.26	ENSG00000244169	.	9291	0.28
chrX_42106034_42106185	0.26	ENSG00000206896	.	72471	0.12
chr11_133944204_133944355	0.26	JAM3	junctional adhesion molecule 3	5313	0.26
chr5_121412020_121412268	0.26	LOX	lysyl oxidase	1836	0.4
chr15_49715580_49715731	0.26	FGF7	fibroblast growth factor 7	198	0.96
chr9_91606379_91607009	0.26	S1PR3	sphingosine-1-phosphate receptor 3	332	0.78
chr8_50969798_50969978	0.26	SNTG1	syntrophin, gamma 1	145183	0.05
chr13_94361906_94362057	0.26	GPC6-AS2	GPC6 antisense RNA 2	126416	0.06
chr7_15723868_15724269	0.26	MEOX2	mesenchyme homeobox 2	2369	0.37
chr20_46043998_46044155	0.26	ZMYND8	zinc finger, MYND-type containing 8	58509	0.09
chr15_48959812_48960090	0.25	FBN1	fibrillin 1	21905	0.23
chr11_12204433_12204584	0.25	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	20805	0.23
chr5_69758456_69758685	0.25	RP11-497H16.7		10705	0.27
chr3_147648289_147648638	0.25	ENSG00000221431	.	19175	0.29
chr12_115813083_115813371	0.25	RP11-116D17.1	HCG2038717; Uncharacterized protein	12410	0.32
chr21_28168221_28168372	0.25	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	47041	0.18
chr5_52211157_52211369	0.25	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	73893	0.1
chr1_101186076_101186227	0.25	VCAM1	vascular cell adhesion molecule 1	831	0.73
chr8_97744511_97744662	0.25	CPQ	carboxypeptidase Q	28616	0.25
chr8_17814649_17814800	0.25	PCM1	pericentriolar material 1	15368	0.21
chr10_33230803_33231099	0.25	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	5772	0.31
chr18_65691492_65691643	0.25	DSEL	dermatan sulfate epimerase-like	507350	0.0
chr20_30457693_30458808	0.25	DUSP15	dual specificity phosphatase 15	125	0.67
chr2_46295244_46295493	0.25	AC017006.2		10599	0.26
chr4_81192543_81192855	0.25	FGF5	fibroblast growth factor 5	4906	0.28
chr12_68055164_68055319	0.25	RP11-335O4.3		9458	0.25
chr4_182878700_182878851	0.25	ENSG00000251742	.	122514	0.06
chr6_11655417_11655591	0.25	ENSG00000207419	.	54548	0.15
chr2_11508011_11508277	0.25	ROCK2	Rho-associated, coiled-coil containing protein kinase 2	23433	0.2
chr9_20604527_20604679	0.25	MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	17269	0.19
chr18_29239238_29239389	0.25	ENSG00000252379	.	10028	0.16
chr6_17282088_17282659	0.25	RBM24	RNA binding motif protein 24	78	0.99
chr12_106667138_106667289	0.24	ENSG00000238609	.	9554	0.17
chr17_70339032_70339432	0.24	SOX9	SRY (sex determining region Y)-box 9	222071	0.02
chr6_19804205_19805055	0.24	ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	32987	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX17

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.1	0.5	GO:0070208	protein heterotrimerization(GO:0070208)
0.1	0.3	GO:0052257	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.1	0.4	GO:0060437	lung growth(GO:0060437)
0.1	0.3	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.1	0.2	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.4	GO:0048251	elastic fiber assembly(GO:0048251)
0.1	0.2	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.1	0.2	GO:0016576	histone dephosphorylation(GO:0016576)
0.1	0.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.4	GO:0008228	opsonization(GO:0008228)
0.1	0.1	GO:0050942	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.1	0.2	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.1	0.3	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.1	0.1	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.1	0.3	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.1	0.1	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.1	0.2	GO:0014034	neural crest formation(GO:0014029) neural crest cell fate commitment(GO:0014034)
0.1	0.2	GO:0048149	behavioral response to ethanol(GO:0048149)
0.1	0.1	GO:0001743	optic placode formation(GO:0001743)
0.1	0.2	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.1	0.2	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.5	GO:0010830	regulation of myotube differentiation(GO:0010830)
0.0	0.2	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.3	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.2	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.2	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.2	GO:0010800	regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.2	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.2	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.2	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.1	GO:0060677	ureteric bud elongation(GO:0060677)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.1	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0	0.1	GO:0051571	positive regulation of histone H3-K4 methylation(GO:0051571)
0.0	0.1	GO:0031033	myosin filament organization(GO:0031033)
0.0	0.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.2	GO:0036296	response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0	0.2	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.4	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.2	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.3	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.2	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.4	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.2	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.5	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.1	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.1	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.1	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.2	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0031274	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.2	GO:0090399	replicative senescence(GO:0090399)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.2	GO:0051294	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.0	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.0	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.0	GO:0060900	embryonic camera-type eye formation(GO:0060900)
0.0	0.4	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.4	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.2	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.5	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.0	GO:0032351	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.0	GO:0072010	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.2	GO:0007184	SMAD protein import into nucleus(GO:0007184)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0031498	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.2	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.0	GO:0071801	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.0	GO:0060872	semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0060363	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.0	GO:0021877	forebrain neuron fate commitment(GO:0021877)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.1	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.2	GO:0048566	embryonic digestive tract development(GO:0048566)
0.0	0.1	GO:0033687	osteoblast proliferation(GO:0033687)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152) kidney smooth muscle tissue development(GO:0072194)
0.0	0.0	GO:0021891	olfactory bulb interneuron development(GO:0021891)
0.0	0.1	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.1	GO:0090026	regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.0	GO:0051459	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0010560	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.1	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.2	GO:0043113	receptor clustering(GO:0043113)
0.0	0.3	GO:0001893	maternal placenta development(GO:0001893)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0048520	positive regulation of behavior(GO:0048520)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.1	GO:0048712	negative regulation of astrocyte differentiation(GO:0048712)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0072338	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.1	GO:0006895	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812) negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.0	GO:0016137	glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.0	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.2	GO:0045103	intermediate filament-based process(GO:0045103)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.0	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.0	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.2	GO:0050715	positive regulation of cytokine secretion(GO:0050715)
0.0	0.1	GO:0009820	alkaloid metabolic process(GO:0009820)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0007442	hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0	0.2	GO:0007566	embryo implantation(GO:0007566)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.3	GO:0070374	positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.0	0.1	GO:0048485	sympathetic nervous system development(GO:0048485)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.6	GO:0042472	inner ear morphogenesis(GO:0042472)
0.0	0.2	GO:0001755	neural crest cell migration(GO:0001755)
0.0	0.1	GO:0060347	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.1	GO:0061001	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.2	GO:0030318	melanocyte differentiation(GO:0030318) pigment cell differentiation(GO:0050931)
0.0	0.0	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.0	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.0	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0001865	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0006515	misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0	0.0	GO:0060122	inner ear receptor stereocilium organization(GO:0060122)
0.0	0.0	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.0	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.0	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.5	GO:0030198	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0	0.0	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.2	GO:0032611	interleukin-1 beta production(GO:0032611)
0.0	0.1	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0030517	negative regulation of axon extension(GO:0030517)
0.0	0.1	GO:0032119	sequestering of zinc ion(GO:0032119)
0.0	0.1	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.0	GO:0003207	cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211)
0.0	0.0	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.0	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.0	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.0	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0043247	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.0	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0070852	cell body fiber(GO:0070852)
0.1	0.4	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.2	GO:0001940	male pronucleus(GO:0001940)
0.1	0.2	GO:0043083	synaptic cleft(GO:0043083)
0.1	0.2	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1	0.4	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	0.3	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.1	0.2	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1	0.2	GO:0043218	compact myelin(GO:0043218)
0.1	0.3	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.3	GO:0016342	catenin complex(GO:0016342)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.2	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.2	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.0	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.2	GO:0008091	spectrin(GO:0008091)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.5	GO:0030018	Z disc(GO:0030018)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.0	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.9	GO:0044420	extracellular matrix component(GO:0044420)
0.0	0.1	GO:0036126	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.2	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0005581	collagen trimer(GO:0005581)
0.0	0.1	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0	0.2	GO:0005811	lipid particle(GO:0005811)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.7	GO:0030426	growth cone(GO:0030426)
0.0	2.2	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	0.1	GO:0070083	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.1	GO:0032300	mismatch repair complex(GO:0032300)
0.0	0.0	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.2	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.3	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.2	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1	0.5	GO:0070628	proteasome binding(GO:0070628)
0.1	0.3	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.2	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1	0.3	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1	0.5	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.2	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.2	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.3	GO:0017166	vinculin binding(GO:0017166)
0.0	0.3	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.3	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.2	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.4	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.2	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.8	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.4	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.6	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.2	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.0	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.2	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.0	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.3	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.1	GO:0005497	androgen binding(GO:0005497)
0.0	0.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.5	GO:0005518	collagen binding(GO:0005518)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.1	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.3	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.0	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.0	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0071617	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.0	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0044390	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.0	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.0	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.1	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.0	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.0	GO:0035241	protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0	0.1	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.0	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.0	0.0	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.0	GO:0032052	bile acid binding(GO:0032052)
0.0	0.1	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	2.5	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.4	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.5	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	0.2	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.3	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	0.1	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.2	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.6	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.0	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.3	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
1.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.4	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.2	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.3	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME PEPTIDE HORMONE BIOSYNTHESIS	Genes involved in Peptide hormone biosynthesis
0.0	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.2	REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	Genes involved in TRAF6 mediated induction of TAK1 complex
0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.3	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.4	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation