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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SOX5

Z-value: 1.18

Motif logo

Transcription factors associated with SOX5

Gene Symbol	Gene ID	Gene Info
SOX5 Ensembl NCBI GeneCards UniProt	ENSG00000134532.11	SOX5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SOX5	chr12_24102871_24103025	311	0.948913	0.70	3.7e-02	Click!
SOX5	chr12_24103066_24103383	587	0.864093	0.65	5.8e-02	Click!
SOX5	chr12_24102324_24102475	182	0.975163	0.65	5.9e-02	Click!
SOX5	chr12_24199012_24199210	95145	0.092801	0.62	7.3e-02	Click!
SOX5	chr12_24048929_24049080	43	0.988942	0.52	1.5e-01	Click!

Activity of the SOX5 motif across conditions

Conditions sorted by the z-value of the SOX5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_114714851_114715858	0.43	RP11-57H14.2		3720	0.26
chr11_131780761_131781452	0.36	NTM	neurotrimin	209	0.95
chr4_55095719_55096018	0.35	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	142	0.98
chr6_27584810_27585278	0.33	ENSG00000238648	.	14144	0.19
chr8_19148668_19149118	0.33	SH2D4A	SH2 domain containing 4A	22235	0.28
chr15_49716260_49716444	0.31	FGF7	fibroblast growth factor 7	895	0.66
chr2_189839524_189839773	0.31	COL3A1	collagen, type III, alpha 1	549	0.79
chr3_87036535_87037613	0.29	VGLL3	vestigial like 3 (Drosophila)	2778	0.42
chr7_93552303_93552503	0.28	GNG11	guanine nucleotide binding protein (G protein), gamma 11	1392	0.38
chr7_19155713_19156221	0.28	TWIST1	twist family bHLH transcription factor 1	1328	0.36
chr18_31157392_31158104	0.27	ASXL3	additional sex combs like 3 (Drosophila)	848	0.76
chr8_142289533_142290316	0.27	RP11-10J21.3	Uncharacterized protein	25260	0.12
chr2_189841718_189841869	0.26	ENSG00000221502	.	1025	0.55
chr1_178064247_178064419	0.25	RASAL2	RAS protein activator like 2	1057	0.69
chr2_9815742_9816384	0.23	YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta	44920	0.13
chr11_121964934_121965228	0.23	ENSG00000207971	.	5471	0.18
chr9_133656128_133656348	0.23	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	54215	0.13
chr1_172110530_172111247	0.23	ENSG00000207949	.	2841	0.22
chr7_127307743_127307970	0.22	SND1	staphylococcal nuclease and tudor domain containing 1	15622	0.17
chr11_121800761_121801203	0.22	ENSG00000252556	.	74081	0.11
chr5_134825154_134825603	0.22	TIFAB	TRAF-interacting protein with forkhead-associated domain, family member B	37289	0.11
chr10_69831641_69832005	0.21	HERC4	HECT and RLD domain containing E3 ubiquitin protein ligase 4	2071	0.33
chr11_9548903_9549060	0.21	ZNF143	zinc finger protein 143	14937	0.16
chr6_85482826_85483217	0.21	TBX18	T-box 18	8784	0.3
chr4_159093168_159093728	0.21	RP11-597D13.9		281	0.64
chr9_22008020_22008450	0.20	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	717	0.61
chr3_16217443_16217716	0.20	GALNT15	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15	1363	0.53
chr10_6763782_6764322	0.20	PRKCQ	protein kinase C, theta	141789	0.05
chr9_6218213_6218406	0.20	IL33	interleukin 33	2500	0.39
chr13_36047635_36048256	0.20	MAB21L1	mab-21-like 1 (C. elegans)	2887	0.26
chrX_78003533_78003765	0.20	LPAR4	lysophosphatidic acid receptor 4	421	0.91
chr4_186696107_186696537	0.20	SORBS2	sorbin and SH3 domain containing 2	108	0.98
chr7_90012947_90013805	0.20	CLDN12	claudin 12	341	0.9
chr4_18595427_18595619	0.19	LCORL	ligand dependent nuclear receptor corepressor-like	572024	0.0
chr8_93115764_93116215	0.19	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	475	0.9
chr1_101313202_101313363	0.19	EXTL2	exostosin-like glycosyltransferase 2	46938	0.12
chr2_54195795_54196058	0.18	ACYP2	acylphosphatase 2, muscle type	2049	0.28
chrX_139847648_139847972	0.18	CDR1	cerebellar degeneration-related protein 1, 34kDa	18913	0.23
chr6_53934757_53935103	0.18	MLIP-AS1	MLIP antisense RNA 1	9594	0.22
chr2_152214605_152215087	0.18	TNFAIP6	tumor necrosis factor, alpha-induced protein 6	740	0.63
chr8_72273557_72273741	0.18	EYA1	eyes absent homolog 1 (Drosophila)	446	0.9
chr3_120215962_120216316	0.18	FSTL1	follistatin-like 1	46039	0.16
chr9_133712337_133712924	0.18	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	2177	0.35
chr4_86397582_86397737	0.18	ARHGAP24	Rho GTPase activating protein 24	1268	0.64
chr12_88971091_88971358	0.17	KITLG	KIT ligand	3014	0.3
chr7_30636157_30636308	0.17	ENSG00000196295	.	1807	0.29
chr1_94882933_94883167	0.17	ABCD3	ATP-binding cassette, sub-family D (ALD), member 3	883	0.72
chr18_12076288_12076458	0.17	ANKRD62	ankyrin repeat domain 62	17479	0.16
chr8_107738861_107739281	0.17	OXR1	oxidation resistance 1	658	0.71
chr1_56136277_56136451	0.17	ENSG00000272051	.	185719	0.03
chr6_3749707_3750198	0.17	RP11-420L9.5		1393	0.41
chr12_89619824_89620001	0.17	ENSG00000238302	.	56150	0.16
chr12_78336681_78336916	0.17	NAV3	neuron navigator 3	23258	0.28
chr9_12776574_12776837	0.17	LURAP1L	leucine rich adaptor protein 1-like	1685	0.38
chr12_117036919_117037510	0.17	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	23558	0.24
chr6_150176715_150177267	0.17	RP11-350J20.12		3393	0.15
chr4_102277856_102278206	0.17	PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	8596	0.2
chr2_175711229_175711408	0.17	CHN1	chimerin 1	175	0.97
chr15_61326560_61326811	0.16	RP11-39M21.1		146763	0.04
chr1_179279550_179279920	0.16	SOAT1	sterol O-acyltransferase 1	16280	0.19
chr6_135679919_135680436	0.16	AHI1	Abelson helper integration site 1	52469	0.13
chr6_53928343_53928541	0.16	MLIP-AS1	MLIP antisense RNA 1	16050	0.2
chr6_12491048_12491213	0.16	ENSG00000223321	.	84117	0.11
chr11_12699031_12699547	0.16	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	2239	0.43
chr6_86114788_86115158	0.16	NT5E	5'-nucleotidase, ecto (CD73)	44836	0.19
chr3_127454933_127455119	0.16	MGLL	monoglyceride lipase	174	0.96
chr11_89113858_89114276	0.16	NOX4	NADPH oxidase 4	109833	0.07
chr18_43061735_43061886	0.16	RP11-309E23.2		1373	0.35
chr4_81195528_81195918	0.16	FGF5	fibroblast growth factor 5	7930	0.26
chr2_163098757_163099006	0.16	FAP	fibroblast activation protein, alpha	677	0.75
chr5_54456050_54456451	0.16	GPX8	glutathione peroxidase 8 (putative)	252	0.86
chr4_41215270_41215769	0.16	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	956	0.59
chr4_128553582_128553997	0.16	INTU	inturned planar cell polarity protein	298	0.94
chr21_17654570_17655007	0.16	ENSG00000201025	.	2301	0.46
chr10_128110723_128110922	0.16	ADAM12	ADAM metallopeptidase domain 12	33798	0.19
chr5_149534487_149534742	0.15	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	576	0.7
chr12_106530238_106530817	0.15	NUAK1	NUAK family, SNF1-like kinase, 1	3284	0.3
chr2_166326382_166326565	0.15	CSRNP3	cysteine-serine-rich nuclear protein 3	265	0.96
chr13_45147711_45147927	0.15	TSC22D1	TSC22 domain family, member 1	2573	0.38
chr1_172109829_172110023	0.15	ENSG00000207949	.	1879	0.31
chr8_93074323_93074520	0.15	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	770	0.78
chr1_172112919_172113144	0.15	ENSG00000208024	.	753	0.46
chr9_18475768_18475931	0.15	ADAMTSL1	ADAMTS-like 1	1618	0.53
chr11_121969171_121969347	0.15	ENSG00000207971	.	1293	0.36
chr6_19691587_19692480	0.15	ENSG00000200957	.	49273	0.18
chr3_150088154_150088521	0.15	TSC22D2	TSC22 domain family, member 2	37785	0.2
chr1_86047684_86048329	0.15	CYR61	cysteine-rich, angiogenic inducer, 61	1562	0.37
chr7_41740779_41741576	0.15	INHBA	inhibin, beta A	970	0.56
chr6_169653019_169653284	0.15	THBS2	thrombospondin 2	905	0.7
chr4_152146952_152147499	0.15	SH3D19	SH3 domain containing 19	7	0.98
chr6_148664293_148664728	0.15	SASH1	SAM and SH3 domain containing 1	781	0.74
chr7_116167346_116167524	0.15	CAV1	caveolin 1, caveolae protein, 22kDa	1088	0.46
chr8_17353947_17354148	0.15	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	550	0.83
chr5_54456456_54456818	0.15	GPX8	glutathione peroxidase 8 (putative)	639	0.58
chr12_13350846_13351208	0.15	EMP1	epithelial membrane protein 1	1307	0.55
chr10_95241236_95241428	0.15	MYOF	myoferlin	619	0.72
chr12_54017495_54017675	0.15	ATF7	activating transcription factor 7	2170	0.23
chr3_168759646_168760009	0.15	MECOM	MDS1 and EVI1 complex locus	85995	0.11
chr1_95005421_95005705	0.15	F3	coagulation factor III (thromboplastin, tissue factor)	1630	0.52
chr17_1665908_1666244	0.14	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	47	0.96
chr2_98765349_98765752	0.14	VWA3B	von Willebrand factor A domain containing 3B	61851	0.13
chr5_121305560_121305763	0.14	SRFBP1	serum response factor binding protein 1	8005	0.28
chr7_94027358_94027511	0.14	COL1A2	collagen, type I, alpha 2	3561	0.34
chr12_960802_961189	0.14	WNK1	WNK lysine deficient protein kinase 1	136	0.97
chr1_61586045_61586196	0.14	RP4-802A10.1		4285	0.26
chr13_24045503_24045654	0.14	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	37737	0.21
chr3_55520495_55520928	0.14	WNT5A	wingless-type MMTV integration site family, member 5A	620	0.62
chr8_55294341_55294557	0.14	ENSG00000244107	.	38579	0.17
chr7_28111372_28111552	0.14	JAZF1	JAZF zinc finger 1	159	0.97
chr11_121970307_121971111	0.14	ENSG00000207971	.	157	0.79
chr15_49715580_49715731	0.14	FGF7	fibroblast growth factor 7	198	0.96
chr5_158176993_158177383	0.14	CTD-2363C16.1		232826	0.02
chr4_144208077_144208509	0.14	ENSG00000200049	.	22326	0.19
chr2_190043558_190043796	0.14	COL5A2	collagen, type V, alpha 2	928	0.65
chr18_56245541_56245920	0.14	RP11-126O1.2		21428	0.14
chr7_100770539_100770851	0.14	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	316	0.81
chr4_119811163_119811314	0.14	SYNPO2	synaptopodin 2	1046	0.64
chr3_100785098_100785499	0.14	ABI3BP	ABI family, member 3 (NESH) binding protein	72939	0.11
chr10_15667073_15667371	0.14	ITGA8	integrin, alpha 8	94902	0.09
chr5_72733592_72733937	0.14	FOXD1	forkhead box D1	10588	0.21
chr5_57753977_57754128	0.14	PLK2	polo-like kinase 2	2035	0.38
chr2_190044119_190044339	0.14	COL5A2	collagen, type V, alpha 2	376	0.9
chr2_238318512_238318719	0.14	COL6A3	collagen, type VI, alpha 3	4176	0.24
chr4_23890359_23890765	0.14	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	1096	0.66
chr2_197831667_197831951	0.14	ANKRD44	ankyrin repeat domain 44	33417	0.18
chr15_63673315_63673584	0.14	CA12	carbonic anhydrase XII	585	0.82
chrX_3467246_3467792	0.14	ENSG00000212214	.	17227	0.19
chr5_38555642_38555941	0.14	LIFR	leukemia inhibitory factor receptor alpha	947	0.37
chr4_162267666_162267817	0.14	RP11-234O6.2		32364	0.26
chr3_15838336_15838568	0.14	ANKRD28	ankyrin repeat domain 28	424	0.86
chr11_69458516_69459047	0.14	CCND1	cyclin D1	2807	0.29
chr8_92612283_92612746	0.14	ENSG00000200151	.	5321	0.33
chr7_18549761_18549974	0.14	HDAC9	histone deacetylase 9	931	0.71
chr18_416158_416713	0.13	RP11-720L2.2		7981	0.25
chr3_55520023_55520469	0.13	WNT5A	wingless-type MMTV integration site family, member 5A	1085	0.48
chr12_91575190_91575391	0.13	DCN	decorin	537	0.85
chr1_214723918_214724069	0.13	PTPN14	protein tyrosine phosphatase, non-receptor type 14	573	0.84
chr4_151500686_151500914	0.13	RP11-1336O20.2		559	0.76
chr7_41742004_41742175	0.13	INHBA	inhibin, beta A	617	0.72
chr2_164591967_164592245	0.13	FIGN	fidgetin	411	0.92
chr10_33622034_33622426	0.13	NRP1	neuropilin 1	1080	0.63
chr10_35102663_35102949	0.13	PARD3	par-3 family cell polarity regulator	1443	0.4
chr15_37394480_37395011	0.13	MEIS2	Meis homeobox 2	1241	0.49
chr3_66139685_66140118	0.13	SLC25A26	solute carrier family 25 (S-adenosylmethionine carrier), member 26	20616	0.25
chr10_95239483_95239707	0.13	MYOF	myoferlin	2356	0.29
chr15_49718765_49718970	0.13	FGF7	fibroblast growth factor 7	3410	0.29
chr22_45865037_45865472	0.13	RP1-102D24.5		20630	0.17
chr16_21199797_21200120	0.13	AF001550.7		6210	0.15
chr19_18497517_18497681	0.13	ENSG00000264175	.	227	0.74
chr4_23890131_23890306	0.13	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	1440	0.57
chr19_47735595_47736220	0.13	BBC3	BCL2 binding component 3	116	0.95
chr21_28217168_28217584	0.13	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	352	0.91
chr5_40552090_40552408	0.13	ENSG00000199552	.	102816	0.07
chr3_190580567_190581193	0.13	GMNC	geminin coiled-coil domain containing	476	0.9
chr11_101983358_101983513	0.13	YAP1	Yes-associated protein 1	190	0.94
chr13_38171648_38172094	0.13	POSTN	periostin, osteoblast specific factor	992	0.71
chr12_69418432_69418757	0.13	CPM	carboxypeptidase M	61545	0.11
chr12_13351879_13352395	0.13	EMP1	epithelial membrane protein 1	2417	0.37
chr3_99356455_99356606	0.13	COL8A1	collagen, type VIII, alpha 1	789	0.74
chr12_104982084_104982267	0.13	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	451	0.85
chr1_216773992_216774229	0.13	ESRRG	estrogen-related receptor gamma	122564	0.06
chr3_11196334_11196700	0.13	HRH1	histamine receptor H1	303	0.94
chr11_57529774_57530544	0.13	CTNND1	catenin (cadherin-associated protein), delta 1	869	0.5
chr6_56556821_56557065	0.13	DST	dystonin	49149	0.18
chr12_115119174_115119325	0.13	TBX3	T-box 3	2146	0.36
chr4_111557687_111558154	0.13	PITX2	paired-like homeodomain 2	256	0.95
chr2_163099691_163099877	0.13	FAP	fibroblast activation protein, alpha	182	0.96
chr2_67601751_67601914	0.13	ETAA1	Ewing tumor-associated antigen 1	22619	0.29
chr18_52626293_52626952	0.13	CCDC68	coiled-coil domain containing 68	117	0.97
chr10_111765795_111766267	0.13	ADD3	adducin 3 (gamma)	469	0.79
chr1_182931948_182932121	0.13	ENSG00000264768	.	3324	0.2
chr14_52121858_52122101	0.13	FRMD6	FERM domain containing 6	3281	0.25
chr8_27694457_27694746	0.13	PBK	PDZ binding kinase	998	0.51
chr2_235862821_235863118	0.13	SH3BP4	SH3-domain binding protein 4	2249	0.48
chr2_74780571_74780754	0.13	LOXL3	lysyl oxidase-like 3	400	0.5
chr11_95835777_95835928	0.13	MTMR2	myotubularin related protein 2	178393	0.03
chr3_114790362_114790748	0.13	ZBTB20	zinc finger and BTB domain containing 20	333	0.94
chr11_79148844_79149050	0.13	TENM4	teneurin transmembrane protein 4	2748	0.3
chr22_38864455_38864654	0.13	KDELR3	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3	471	0.74
chr5_124536368_124536614	0.13	ENSG00000222107	.	150333	0.05
chr15_63337269_63337696	0.13	TPM1	tropomyosin 1 (alpha)	1507	0.37
chr6_56557534_56557976	0.13	DST	dystonin	49961	0.18
chr7_23286622_23287130	0.13	GPNMB	glycoprotein (transmembrane) nmb	482	0.83
chr1_170634717_170634868	0.13	PRRX1	paired related homeobox 1	1714	0.5
chr3_124604600_124604823	0.12	ITGB5	integrin, beta 5	1433	0.47
chr5_54457024_54457471	0.12	GPX8	glutathione peroxidase 8 (putative)	1249	0.31
chr7_130595370_130595521	0.12	ENSG00000226380	.	33147	0.2
chr9_13787422_13787665	0.12	NFIB	nuclear factor I/B	393248	0.01
chr18_73688861_73689088	0.12	RP11-94B19.4	Uncharacterized protein	282147	0.01
chr11_133995025_133995278	0.12	NCAPD3	non-SMC condensin II complex, subunit D3	43216	0.13
chr14_27065632_27065895	0.12	NOVA1	neuro-oncological ventral antigen 1	482	0.74
chr7_27218725_27218915	0.12	RP1-170O19.20	Uncharacterized protein	812	0.27
chr3_29325145_29325351	0.12	RBMS3	RNA binding motif, single stranded interacting protein 3	2141	0.37
chr21_17442999_17443232	0.12	ENSG00000252273	.	35286	0.24
chr10_4285552_4285907	0.12	ENSG00000207124	.	271415	0.02
chr7_55088709_55088860	0.12	EGFR	epidermal growth factor receptor	1973	0.48
chr9_22084576_22084735	0.12	CDKN2B-AS1	CDKN2B antisense RNA 1	29022	0.19
chr13_35963159_35963423	0.12	MAB21L1	mab-21-like 1 (C. elegans)	87541	0.09
chr15_56206351_56206878	0.12	NEDD4	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	1238	0.55
chr14_73492682_73492833	0.12	ZFYVE1	zinc finger, FYVE domain containing 1	1057	0.51

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.1	0.4	GO:0060437	lung growth(GO:0060437)
0.1	0.2	GO:1903054	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1	0.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.2	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.1	GO:0031223	auditory behavior(GO:0031223)
0.1	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.1	0.2	GO:0016576	histone dephosphorylation(GO:0016576)
0.1	0.3	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.2	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.1	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.1	0.2	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.1	0.3	GO:0097435	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.1	0.2	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.1	GO:0071504	cellular response to heparin(GO:0071504)
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.2	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.2	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.4	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.3	GO:0055093	response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0	0.2	GO:0070141	response to UV-A(GO:0070141)
0.0	0.2	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.2	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.0	0.4	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.0	0.2	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.2	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.2	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.2	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.2	GO:0060363	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0003181	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.3	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0070933	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.2	GO:0010719	negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.2	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0	0.1	GO:0001743	optic placode formation(GO:0001743)
0.0	0.2	GO:0036303	lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0	0.1	GO:0090196	chemokine secretion(GO:0090195) regulation of chemokine secretion(GO:0090196) positive regulation of chemokine secretion(GO:0090197)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0015802	basic amino acid transport(GO:0015802)
0.0	0.2	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.1	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.1	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0071698	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0010667	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:2000108	positive regulation of leukocyte apoptotic process(GO:2000108)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.3	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0033630	positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.1	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0061001	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.0	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.0	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:0002076	osteoblast development(GO:0002076)
0.0	0.0	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.1	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.1	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.3	GO:0008038	neuron recognition(GO:0008038)
0.0	0.0	GO:0051280	negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.0	GO:0070572	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.2	GO:0030325	adrenal gland development(GO:0030325)
0.0	0.2	GO:0042474	middle ear morphogenesis(GO:0042474)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.0	GO:0030573	bile acid catabolic process(GO:0030573)
0.0	0.3	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.1	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.0	0.0	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.0	GO:0090244	Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.0	GO:0060214	endocardium development(GO:0003157) endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.1	GO:0045920	negative regulation of exocytosis(GO:0045920)
0.0	0.1	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0002913	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.0	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0003214	cardiac left ventricle morphogenesis(GO:0003214)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.3	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.1	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.0	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.0	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.0	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.2	GO:0051897	positive regulation of protein kinase B signaling(GO:0051897)
0.0	0.0	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.0	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0	0.0	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.0	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.3	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.0	GO:0048311	mitochondrion distribution(GO:0048311)
0.0	0.1	GO:0021955	central nervous system neuron axonogenesis(GO:0021955)
0.0	0.0	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.0	GO:0060744	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.0	GO:1903513	retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.0	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:0090399	replicative senescence(GO:0090399)
0.0	0.0	GO:0071305	cellular response to vitamin D(GO:0071305)
0.0	0.1	GO:0007379	segment specification(GO:0007379)
0.0	0.0	GO:2000050	regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0042733	embryonic digit morphogenesis(GO:0042733)
0.0	0.1	GO:0001893	maternal placenta development(GO:0001893)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0042693	muscle cell fate commitment(GO:0042693)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.3	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.2	GO:0071438	invadopodium membrane(GO:0071438)
0.1	0.6	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	0.4	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.2	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.4	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.2	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.4	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.5	GO:0032432	actin filament bundle(GO:0032432)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.3	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.9	GO:0030426	growth cone(GO:0030426)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.4	GO:0030018	Z disc(GO:0030018)
0.0	0.2	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.2	0.5	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.4	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.7	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	0.2	GO:0050815	phosphoserine binding(GO:0050815)
0.1	0.2	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.3	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.3	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.4	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.3	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.2	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.2	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.3	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.3	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.2	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.1	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.2	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.0	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.3	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.0	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.0	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.2	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.0	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.0	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.0	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.0	GO:1990939	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0070888	E-box binding(GO:0070888)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
1.3	NABA COLLAGENS	Genes encoding collagen proteins
0.5	PID ALK1 PATHWAY	ALK1 signaling events
0.6	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.5	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.3	PID S1P S1P3 PATHWAY	S1P3 pathway
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.4	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
1.1	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.6	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
1.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.3	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.5	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	Genes involved in p53-Independent G1/S DNA damage checkpoint
0.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.2	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	REACTOME PI 3K CASCADE	Genes involved in PI-3K cascade
0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.3	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling