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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for SOX6

Z-value: 1.12

Motif logo

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Transcription factors associated with SOX6

Gene Symbol Gene ID Gene Info
SOX6
ENSG00000110693.11 SRY-box transcription factor 6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr11_16302023_16302174SOX6607170.1536100.333.8e-01Click!
chr11_16349162_16349313SOX6135780.3019080.206.1e-01Click!
chr11_16301713_16301864SOX6610270.1528020.196.3e-01Click!
chr11_16490337_16490488SOX675230.308262-0.059.0e-01Click!

Activity of the SOX6 motif across conditions

Conditions sorted by the z-value of the SOX6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr17_58821066_58821723 0.50 ENSG00000252534
 .
 5013
 0.22
chr19_34359259_34359976 0.48 ENSG00000240626
 .
 58913
 0.13
chr9_18476160_18476529 0.46 ADAMTSL1
 ADAMTS-like 1
 2113
 0.45
chr4_157890038_157890662 0.32 PDGFC
 platelet derived growth factor C
 1705
 0.41
chrX_40004759_40006118 0.31 BCOR
 BCL6 corepressor
 444
 0.9
chr1_172109829_172110023 0.30 ENSG00000207949
 .
 1879
 0.31
chr2_1711742_1712354 0.30 PXDN
 peroxidasin homolog (Drosophila)
 15706
 0.26
chr17_38601617_38601849 0.30 IGFBP4
 insulin-like growth factor binding protein 4
 2020
 0.24
chr9_12776574_12776837 0.30 LURAP1L
 leucine rich adaptor protein 1-like
 1685
 0.38
chr9_13568681_13569117 0.29 MPDZ
 multiple PDZ domain protein
 289310
 0.01
chr15_95388341_95388759 0.29 MCTP2
 multiple C2 domains, transmembrane 2
 489347
 0.01
chr8_93115764_93116215 0.29 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
 475
 0.9
chr7_93465582_93465846 0.28 TFPI2
 tissue factor pathway inhibitor 2
 53768
 0.12
chr3_149938739_149938966 0.28 RP11-167H9.4
123033
 0.05
chr15_39876247_39876621 0.28 THBS1
 thrombospondin 1
 3140
 0.25
chr10_74854683_74854852 0.28 P4HA1
 prolyl 4-hydroxylase, alpha polypeptide I
 1841
 0.21
chr11_131780761_131781452 0.28 NTM
 neurotrimin
 209
 0.95
chr4_81195528_81195918 0.27 FGF5
 fibroblast growth factor 5
 7930
 0.26
chr2_102051443_102051701 0.27 RFX8
 RFX family member 8, lacking RFX DNA binding domain
 39165
 0.16
chr12_118626563_118627015 0.27 TAOK3
 TAO kinase 3
 1538
 0.42
chr17_78044749_78045392 0.27 CCDC40
 coiled-coil domain containing 40
 12346
 0.15
chr1_164529222_164529675 0.27 PBX1
 pre-B-cell leukemia homeobox 1
 388
 0.91
chr11_121800761_121801203 0.27 ENSG00000252556
 .
 74081
 0.11
chr3_120149251_120149402 0.27 FSTL1
 follistatin-like 1
 20512
 0.22
chr8_42054040_42054280 0.26 PLAT
 plasminogen activator, tissue
 944
 0.52
chr2_200446222_200446758 0.26 SATB2
 SATB homeobox 2
 110501
 0.07
chr7_39504844_39505021 0.26 POU6F2-AS1
 POU6F2 antisense RNA 1
 58987
 0.12
chr7_41738474_41738677 0.26 INHBA
 inhibin, beta A
 1632
 0.38
chr6_3324359_3324736 0.26 RP11-506K6.4
12651
 0.23
chr1_150245669_150245859 0.26 C1orf54
 chromosome 1 open reading frame 54
 581
 0.54
chr2_68953487_68953638 0.26 ARHGAP25
 Rho GTPase activating protein 25
 8351
 0.26
chr11_124768607_124768899 0.26 ROBO4
 roundabout, axon guidance receptor, homolog 4 (Drosophila)
 576
 0.61
chr7_27218725_27218915 0.26 RP1-170O19.20
 Uncharacterized protein
 812
 0.27
chr3_49064758_49065280 0.26 IMPDH2
 IMP (inosine 5'-monophosphate) dehydrogenase 2
 887
 0.3
chr4_128553582_128553997 0.25 INTU
 inturned planar cell polarity protein
 298
 0.94
chr15_80696207_80696642 0.25 ARNT2
 aryl-hydrocarbon receptor nuclear translocator 2
 269
 0.71
chr4_171010363_171010619 0.25 AADAT
 aminoadipate aminotransferase
 54
 0.98
chr5_83680091_83680703 0.25 CTD-2269F5.1
23
 0.71
chr12_71003154_71004126 0.24 PTPRB
 protein tyrosine phosphatase, receptor type, B
 16
 0.99
chr1_94219763_94219914 0.24 RP11-488P3.1
21162
 0.21
chr7_92327766_92328157 0.24 ENSG00000206763
 .
 3167
 0.33
chr9_128288246_128288397 0.24 ENSG00000243845
 .
 12835
 0.21
chr5_113697124_113698006 0.24 KCNN2
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
 451
 0.9
chr13_24007498_24007984 0.24 SACS
 spastic ataxia of Charlevoix-Saguenay (sacsin)
 100
 0.98
chr8_108344303_108344567 0.24 ANGPT1
 angiopoietin 1
 4315
 0.34
chr15_23743478_23743629 0.24 GOLGA6L2
 golgin A6 family-like 2
 51172
 0.11
chr1_79471738_79472138 0.24 ELTD1
 EGF, latrophilin and seven transmembrane domain containing 1
 465
 0.9
chr6_111738419_111738706 0.24 REV3L-IT1
 REV3L intronic transcript 1 (non-protein coding)
 55752
 0.11
chr15_99847895_99848073 0.24 AC022819.2
 Uncharacterized protein
 11844
 0.18
chr21_46573548_46573916 0.23 ADARB1
 adenosine deaminase, RNA-specific, B1
 17825
 0.17
chr13_24006860_24007105 0.23 SACS
 spastic ataxia of Charlevoix-Saguenay (sacsin)
 859
 0.74
chr7_111724737_111724893 0.23 DOCK4
 dedicator of cytokinesis 4
 80629
 0.1
chr15_48469342_48470564 0.23 MYEF2
 myelin expression factor 2
 597
 0.66
chr5_67714061_67714212 0.23 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 125740
 0.06
chr18_6729547_6730123 0.23 ARHGAP28
 Rho GTPase activating protein 28
 14
 0.5
chr10_104536012_104536214 0.23 WBP1L
 WW domain binding protein 1-like
 107
 0.96
chr1_33812781_33812932 0.23 PHC2
 polyhomeotic homolog 2 (Drosophila)
 2630
 0.17
chr6_7692698_7692863 0.23 BMP6
 bone morphogenetic protein 6
 34250
 0.21
chr2_238318512_238318719 0.23 COL6A3
 collagen, type VI, alpha 3
 4176
 0.24
chr18_74333391_74333920 0.23 LINC00908
 long intergenic non-protein coding RNA 908
 92781
 0.08
chr10_6962147_6962542 0.23 PRKCQ
 protein kinase C, theta
 340081
 0.01
chr19_18497517_18497681 0.22 ENSG00000264175
 .
 227
 0.74
chr4_124365503_124365798 0.22 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 44527
 0.21
chr12_91721216_91721367 0.22 DCN
 decorin
 144391
 0.05
chr11_64215600_64216212 0.22 AP003774.4
 HCG1652096, isoform CRA_a; Uncharacterized protein; cDNA FLJ37045 fis, clone BRACE2012185
 640
 0.68
chr9_132246124_132246361 0.22 ENSG00000264298
 .
 5407
 0.24
chr22_30640971_30641213 0.22 RP1-102K2.8
892
 0.38
chr11_65639318_65639911 0.22 EFEMP2
 EGF containing fibulin-like extracellular matrix protein 2
 511
 0.56
chr7_90012947_90013805 0.22 CLDN12
 claudin 12
 341
 0.9
chr8_2199973_2200269 0.22 MYOM2
 myomesin 2
 206937
 0.03
chr7_95690232_95690383 0.22 ENSG00000208025
 .
 158761
 0.04
chr4_86700210_86700446 0.22 ARHGAP24
 Rho GTPase activating protein 24
 469
 0.88
chr20_23617810_23618640 0.22 CST3
 cystatin C
 357
 0.87
chr7_82071524_82071810 0.22 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 1364
 0.61
chr7_116661589_116661740 0.21 ST7
 suppression of tumorigenicity 7
 1333
 0.44
chr5_158438402_158438767 0.21 CTD-2363C16.2
25770
 0.2
chr15_52943999_52944218 0.21 FAM214A
 family with sequence similarity 214, member A
 139
 0.95
chrX_78003533_78003765 0.21 LPAR4
 lysophosphatidic acid receptor 4
 421
 0.91
chr15_77480576_77480727 0.21 PEAK1
 pseudopodium-enriched atypical kinase 1
 64222
 0.12
chr10_77229198_77229525 0.21 RP11-399K21.10
38015
 0.16
chr14_63671002_63671585 0.21 RHOJ
 ras homolog family member J
 167
 0.97
chr19_36207272_36208543 0.21 KMT2B
 Histone-lysine N-methyltransferase 2B
 1014
 0.26
chr3_152314332_152314547 0.21 RP11-362A9.3
99837
 0.08
chr2_121499238_121499672 0.21 GLI2
 GLI family zinc finger 2
 5632
 0.32
chr17_39861478_39861907 0.21 GAST
 gastrin
 6886
 0.1
chr10_34630198_34630349 0.21 PARD3
 par-3 family cell polarity regulator
 31188
 0.25
chr9_94183221_94183836 0.21 NFIL3
 nuclear factor, interleukin 3 regulated
 2616
 0.4
chr22_46471692_46472277 0.21 FLJ27365
 hsa-mir-4763
 4208
 0.11
chr3_175244326_175245006 0.21 ENSG00000201648
 .
 82601
 0.1
chr2_189839524_189839773 0.21 COL3A1
 collagen, type III, alpha 1
 549
 0.79
chr3_112358713_112358917 0.21 CCDC80
 coiled-coil domain containing 80
 1301
 0.54
chr3_194840398_194840606 0.21 XXYLT1
 xyloside xylosyltransferase 1
 2419
 0.23
chrX_3379202_3379389 0.21 ENSG00000212214
 .
 70997
 0.11
chr8_25042452_25043634 0.20 DOCK5
 dedicator of cytokinesis 5
 663
 0.75
chr22_45865037_45865472 0.20 RP1-102D24.5
20630
 0.17
chr7_83768499_83768650 0.20 SEMA3A
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
 55643
 0.18
chr6_56706635_56706858 0.20 DST
 dystonin
 1197
 0.47
chr9_130639317_130639975 0.20 AK1
 adenylate kinase 1
 376
 0.71
chr15_96883311_96883827 0.20 ENSG00000222651
 .
 7079
 0.16
chr3_66139685_66140118 0.20 SLC25A26
 solute carrier family 25 (S-adenosylmethionine carrier), member 26
 20616
 0.25
chr3_106064913_106065064 0.20 ENSG00000200610
 .
 169756
 0.04
chr12_32687758_32688027 0.20 FGD4
 FYVE, RhoGEF and PH domain containing 4
 634
 0.8
chr2_216299376_216299642 0.20 FN1
 fibronectin 1
 1281
 0.4
chr1_162602563_162603214 0.20 DDR2
 discoidin domain receptor tyrosine kinase 2
 628
 0.74
chr5_115961898_115962197 0.20 SEMA6A
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
 51417
 0.18
chr5_151060368_151060611 0.20 CTB-113P19.1
3955
 0.17
chr2_189842191_189842342 0.20 ENSG00000221502
 .
 552
 0.78
chr11_123059250_123059539 0.20 CTD-2216M2.1
116
 0.97
chr8_87718795_87718946 0.20 RP11-386D6.1
905
 0.65
chr2_188417302_188417453 0.20 AC007319.1
1499
 0.38
chr17_48366854_48367409 0.20 RP11-893F2.9
1915
 0.24
chr13_110958781_110959436 0.20 COL4A1
 collagen, type IV, alpha 1
 370
 0.6
chr14_52121858_52122101 0.20 FRMD6
 FERM domain containing 6
 3281
 0.25
chr1_54587067_54587332 0.20 AL161915.1
 Uncharacterized protein
 17231
 0.13
chr7_27202641_27202952 0.20 HOXA9
 homeobox A9
 2349
 0.09
chr15_42749089_42749416 0.20 ZNF106
 zinc finger protein 106
 459
 0.78
chr17_19966866_19967068 0.20 SPECC1
 sperm antigen with calponin homology and coiled-coil domains 1
 23367
 0.18
chr8_25946426_25946850 0.20 EBF2
 early B-cell factor 2
 43725
 0.17
chr1_244609044_244609215 0.20 ADSS
 adenylosuccinate synthase
 6307
 0.21
chr8_108507547_108507698 0.20 ANGPT1
 angiopoietin 1
 399
 0.92
chr10_114714851_114715858 0.19 RP11-57H14.2
3720
 0.26
chr9_18976648_18977105 0.19 FAM154A
 family with sequence similarity 154, member A
 56310
 0.1
chr1_78356045_78356196 0.19 NEXN-AS1
 NEXN antisense RNA 1
 896
 0.52
chr22_46423027_46423794 0.19 RP6-109B7.5
25563
 0.09
chr7_94004298_94004620 0.19 COL1A2
 collagen, type I, alpha 2
 19414
 0.26
chr8_117133283_117133521 0.19 ENSG00000221793
 .
 15596
 0.28
chrX_103381032_103381192 0.19 SLC25A53
 solute carrier family 25, member 53
 20596
 0.16
chr19_30865612_30866061 0.19 ZNF536
 zinc finger protein 536
 2517
 0.44
chr6_143193241_143193570 0.19 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 35221
 0.21
chr2_89180194_89180345 0.19 IGKV4-1
 immunoglobulin kappa variable 4-1
 4644
 0.09
chr12_78336681_78336916 0.19 NAV3
 neuron navigator 3
 23258
 0.28
chr10_62059868_62060258 0.19 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 177
 0.97
chr1_68084153_68084510 0.19 ENSG00000242482
 .
 38481
 0.16
chr14_85998039_85998552 0.19 FLRT2
 fibronectin leucine rich transmembrane protein 2
 1723
 0.42
chr2_14633353_14633613 0.19 FAM84A
 family with sequence similarity 84, member A
 139327
 0.05
chr11_8740394_8740932 0.19 ST5
 suppression of tumorigenicity 5
 27
 0.96
chr5_15500636_15500842 0.19 FBXL7
 F-box and leucine-rich repeat protein 7
 434
 0.91
chr2_66663002_66663153 0.19 MEIS1
 Meis homeobox 1
 387
 0.81
chr16_53244996_53245358 0.19 CHD9
 chromodomain helicase DNA binding protein 9
 2814
 0.29
chr2_144303459_144303649 0.19 RP11-570L15.2
26120
 0.19
chr6_76059036_76059425 0.19 RP11-415D17.3
7700
 0.18
chr17_47077080_47077320 0.19 IGF2BP1
 insulin-like growth factor 2 mRNA binding protein 1
 2092
 0.16
chr1_201619186_201619405 0.19 NAV1
 neuron navigator 1
 1845
 0.29
chr12_105627028_105627183 0.19 APPL2
 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
 123
 0.97
chr13_110954925_110955076 0.19 COL4A2
 collagen, type IV, alpha 2
 3159
 0.28
chr2_188269361_188269539 0.19 CALCRL
 calcitonin receptor-like
 43529
 0.19
chr12_63254560_63254711 0.19 ENSG00000200296
 .
 9954
 0.25
chr9_114671696_114672066 0.19 UGCG
 UDP-glucose ceramide glucosyltransferase
 12835
 0.19
chrX_106898289_106898771 0.19 PRPS1
 phosphoribosyl pyrophosphate synthetase 1
 15942
 0.22
chr12_69809879_69810030 0.19 ENSG00000266185
 .
 15271
 0.18
chr1_172154318_172154604 0.18 DNM3OS
 DNM3 opposite strand/antisense RNA
 40527
 0.14
chrX_110038687_110039773 0.18 CHRDL1
 chordin-like 1
 56
 0.99
chr8_132929065_132929278 0.18 EFR3A
 EFR3 homolog A (S. cerevisiae)
 12815
 0.3
chr10_30346002_30346153 0.18 KIAA1462
 KIAA1462
 2376
 0.44
chr15_34531260_34531657 0.18 EMC4
 ER membrane protein complex subunit 4
 11562
 0.14
chr15_93258311_93258462 0.18 FAM174B
 family with sequence similarity 174, member B
 47113
 0.14
chr3_16217443_16217716 0.18 GALNT15
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
 1363
 0.53
chr7_158314531_158314682 0.18 ENSG00000207637
 .
 10899
 0.17
chr17_42544837_42545068 0.18 GPATCH8
 G patch domain containing 8
 35807
 0.12
chr12_115889459_115889637 0.18 RP11-116D17.1
 HCG2038717; Uncharacterized protein
 88731
 0.1
chr13_38171648_38172094 0.18 POSTN
 periostin, osteoblast specific factor
 992
 0.71
chr2_202901871_202902113 0.18 FZD7
 frizzled family receptor 7
 2682
 0.25
chr20_11871763_11872529 0.18 BTBD3
 BTB (POZ) domain containing 3
 171
 0.97
chrX_49801111_49801262 0.18 ENSG00000272080
 .
 21980
 0.08
chr15_92104669_92104931 0.18 ENSG00000238981
 .
 273809
 0.01
chr17_40284922_40285123 0.18 RAB5C
 RAB5C, member RAS oncogene family
 3427
 0.12
chr17_38440207_38440497 0.18 CDC6
 cell division cycle 6
 3533
 0.16
chr4_159093168_159093728 0.18 RP11-597D13.9
281
 0.64
chr2_232545912_232546437 0.18 MGC4771
25447
 0.14
chr10_113962747_113962898 0.18 GPAM
 glycerol-3-phosphate acyltransferase, mitochondrial
 19297
 0.25
chr15_61327175_61327382 0.18 RP11-39M21.1
146170
 0.04
chr15_37180001_37180243 0.18 ENSG00000212511
 .
 35281
 0.22
chr9_20725861_20726160 0.18 ENSG00000207609
 .
 9906
 0.2
chr3_114788095_114788246 0.18 ZBTB20
 zinc finger and BTB domain containing 20
 2052
 0.5
chr5_86264086_86264257 0.18 ENSG00000251951
 .
 134492
 0.05
chr8_131960988_131961496 0.18 RP11-737F9.1
13587
 0.24
chr5_39421621_39421795 0.18 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 3262
 0.35
chr4_143273250_143273504 0.18 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 46280
 0.21
chr9_113940701_113941000 0.18 ENSG00000212409
 .
 81157
 0.1
chr22_17679684_17679946 0.18 CECR1
 cat eye syndrome chromosome region, candidate 1
 858
 0.6
chrX_129473317_129474471 0.18 SLC25A14
 solute carrier family 25 (mitochondrial carrier, brain), member 14
 7
 0.98
chr8_141248678_141248836 0.18 TRAPPC9
 trafficking protein particle complex 9
 212272
 0.02
chr7_137028027_137028276 0.18 PTN
 pleiotrophin
 369
 0.92
chr18_52942632_52942783 0.18 TCF4
 transcription factor 4
 195
 0.97
chr1_17866390_17866720 0.18 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 225
 0.95
chrX_84499187_84500398 0.18 ZNF711
 zinc finger protein 711
 21
 0.94
chr8_55294582_55295235 0.18 ENSG00000244107
 .
 38120
 0.17
chr10_30872530_30872876 0.17 ENSG00000239744
 .
 27870
 0.19
chrX_69674453_69675874 0.17 DLG3
 discs, large homolog 3 (Drosophila)
 217
 0.75
chr13_101527616_101527852 0.17 NALCN-AS1
 NALCN antisense RNA 1
 167155
 0.04
chr11_16023597_16024065 0.17 CTD-3096P4.1
20905
 0.28
chr4_26022444_26022665 0.17 SMIM20
 small integral membrane protein 20
 106623
 0.07
chr18_9701912_9702261 0.17 RAB31
 RAB31, member RAS oncogene family
 6076
 0.24
chr12_27398836_27399341 0.17 STK38L
 serine/threonine kinase 38 like
 498
 0.86
chr1_56943161_56943502 0.17 ENSG00000223307
 .
 100241
 0.08
chr16_17547681_17547832 0.17 XYLT1
 xylosyltransferase I
 16982
 0.31
chr9_14353312_14353885 0.17 RP11-120J1.1
6279
 0.28
chr2_225847014_225847203 0.17 ENSG00000263828
 .
 28149
 0.22
chr17_60868253_60868692 0.17 MARCH10
 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
 15529
 0.23
chr4_184264353_184264576 0.17 ENSG00000238596
 .
 14013
 0.14

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 0.4 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1 0.4 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.3 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.3 GO:0071694 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.3 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.1 0.3 GO:1903053 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1 0.2 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 0.4 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.1 0.2 GO:0021508 floor plate formation(GO:0021508)
0.1 0.2 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.3 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.2 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.1 0.2 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1 0.2 GO:0022605 oogenesis stage(GO:0022605)
0.1 0.5 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 0.2 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.1 0.1 GO:0060437 lung growth(GO:0060437)
0.1 0.5 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 0.2 GO:0008354 germ cell migration(GO:0008354)
0.1 0.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.2 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.1 0.2 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.1 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.2 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.2 GO:2000178 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.1 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.1 GO:0048343 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0 0.1 GO:0010159 specification of organ position(GO:0010159)
0.0 0.3 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.3 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.0 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0003136 negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.0 0.4 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.1 GO:0051284 negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.1 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.2 GO:0097435 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0 0.2 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.1 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.3 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.1 GO:0032347 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0036303 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0 0.1 GO:0019511 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.2 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.2 GO:0060039 pericardium development(GO:0060039)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.0 GO:0010613 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0 0.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.4 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.0 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.0 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.1 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.0 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.0 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.2 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.5 GO:0008038 neuron recognition(GO:0008038)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0048333 mesodermal cell differentiation(GO:0048333)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.0 GO:0042637 catagen(GO:0042637)
0.0 0.0 GO:0021794 thalamus development(GO:0021794)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.0 0.2 GO:0070189 kynurenine metabolic process(GO:0070189)
0.0 0.1 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0 0.1 GO:0045064 T-helper 2 cell differentiation(GO:0045064)
0.0 0.2 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:1901532 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.0 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.0 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.0 0.0 GO:0061140 lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510) lung secretory cell differentiation(GO:0061140)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.1 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 0.1 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.1 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.1 GO:0071800 podosome assembly(GO:0071800)
0.0 0.0 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.1 GO:0009109 coenzyme catabolic process(GO:0009109)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.4 GO:0051925 obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0 0.3 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.0 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.0 GO:0003078 obsolete regulation of natriuresis(GO:0003078)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0033240 positive regulation of cellular amine metabolic process(GO:0033240)
0.0 0.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.0 GO:0072176 nephric duct development(GO:0072176)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.1 GO:0071398 cellular response to fatty acid(GO:0071398)
0.0 0.1 GO:0042640 anagen(GO:0042640)
0.0 0.0 GO:0031223 response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0 0.0 GO:0051461 corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.1 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0048679 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.1 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.1 GO:0035307 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.0 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.0 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.0 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.0 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.1 GO:0016246 RNA interference(GO:0016246)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.0 GO:0090190 positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.0 GO:0045617 negative regulation of epidermal cell differentiation(GO:0045605) negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.1 GO:0009143 nucleoside triphosphate catabolic process(GO:0009143)
0.0 0.1 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.3 GO:0051101 regulation of DNA binding(GO:0051101)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.0 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.0 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0008347 glial cell migration(GO:0008347)
0.0 0.0 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.0 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.2 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.0 GO:1903312 negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.0 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.1 GO:0043113 receptor clustering(GO:0043113)
0.0 0.0 GO:0030812 negative regulation of nucleotide catabolic process(GO:0030812)
0.0 0.0 GO:0003157 endocardium development(GO:0003157) endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214)
0.0 0.0 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0030539 male genitalia development(GO:0030539)
0.0 0.1 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.0 GO:0060900 optic cup morphogenesis involved in camera-type eye development(GO:0002072) embryonic camera-type eye formation(GO:0060900)
0.0 0.0 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.0 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.2 GO:0001893 maternal placenta development(GO:0001893)
0.0 0.0 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.2 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 0.0 GO:0072191 positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193) kidney smooth muscle tissue development(GO:0072194)
0.0 0.0 GO:0036445 neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0 0.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.0 GO:0016265 obsolete death(GO:0016265)
0.0 0.0 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0 0.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0009264 deoxyribonucleotide catabolic process(GO:0009264) deoxyribose phosphate catabolic process(GO:0046386)
0.0 0.0 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.0 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.0 GO:0007494 midgut development(GO:0007494)
0.0 0.0 GO:0015811 sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0 0.1 GO:0044091 membrane biogenesis(GO:0044091)
0.0 0.0 GO:2000909 regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.0 0.0 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.0 GO:0071436 sodium ion export(GO:0071436)
0.0 0.0 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.0 GO:1903020 positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0 0.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:0007184 SMAD protein import into nucleus(GO:0007184)
0.0 0.1 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.0 GO:0002138 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.0 GO:0097094 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.1 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.0 GO:0008356 asymmetric cell division(GO:0008356)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070852 cell body fiber(GO:0070852)
0.1 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.3 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 0.3 GO:0001527 microfibril(GO:0001527)
0.1 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.0 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.0 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.7 GO:0005902 microvillus(GO:0005902)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0000801 central element(GO:0000801)
0.0 1.2 GO:0030426 growth cone(GO:0030426)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.5 GO:0034704 calcium channel complex(GO:0034704)
0.0 0.5 GO:0030018 Z disc(GO:0030018)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.0 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.7 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.1 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.0 GO:0043205 fibril(GO:0043205)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.6 GO:0070628 proteasome binding(GO:0070628)
0.1 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.2 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.2 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.2 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.3 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.2 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.1 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.2 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.1 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.3 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.0 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0043394 proteoglycan binding(GO:0043394)
0.0 0.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.0 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.0 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 0.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.0 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0 0.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.0 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.0 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0015368 calcium:cation antiporter activity(GO:0015368)
0.0 0.5 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.0 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.0 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.6 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.1 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.0 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.0 GO:0005534 galactose binding(GO:0005534)
0.0 0.0 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.0 0.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.0 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.2 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.9 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.0 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.1 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.0 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.3 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.2 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID FGF PATHWAY FGF signaling pathway
0.0 0.0 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 0.1 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.1 1.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR