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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SOX6

Z-value: 1.12

Motif logo

Transcription factors associated with SOX6

Gene Symbol	Gene ID	Gene Info
SOX6 Ensembl NCBI GeneCards UniProt	ENSG00000110693.11	SOX6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SOX6	chr11_16302023_16302174	60717	0.153610	0.33	3.8e-01	Click!
SOX6	chr11_16349162_16349313	13578	0.301908	0.20	6.1e-01	Click!
SOX6	chr11_16301713_16301864	61027	0.152802	0.19	6.3e-01	Click!
SOX6	chr11_16490337_16490488	7523	0.308262	-0.05	9.0e-01	Click!

Activity of the SOX6 motif across conditions

Conditions sorted by the z-value of the SOX6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_58821066_58821723	0.50	ENSG00000252534	.	5013	0.22
chr19_34359259_34359976	0.48	ENSG00000240626	.	58913	0.13
chr9_18476160_18476529	0.46	ADAMTSL1	ADAMTS-like 1	2113	0.45
chr4_157890038_157890662	0.32	PDGFC	platelet derived growth factor C	1705	0.41
chrX_40004759_40006118	0.31	BCOR	BCL6 corepressor	444	0.9
chr1_172109829_172110023	0.30	ENSG00000207949	.	1879	0.31
chr2_1711742_1712354	0.30	PXDN	peroxidasin homolog (Drosophila)	15706	0.26
chr17_38601617_38601849	0.30	IGFBP4	insulin-like growth factor binding protein 4	2020	0.24
chr9_12776574_12776837	0.30	LURAP1L	leucine rich adaptor protein 1-like	1685	0.38
chr9_13568681_13569117	0.29	MPDZ	multiple PDZ domain protein	289310	0.01
chr15_95388341_95388759	0.29	MCTP2	multiple C2 domains, transmembrane 2	489347	0.01
chr8_93115764_93116215	0.29	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	475	0.9
chr7_93465582_93465846	0.28	TFPI2	tissue factor pathway inhibitor 2	53768	0.12
chr3_149938739_149938966	0.28	RP11-167H9.4		123033	0.05
chr15_39876247_39876621	0.28	THBS1	thrombospondin 1	3140	0.25
chr10_74854683_74854852	0.28	P4HA1	prolyl 4-hydroxylase, alpha polypeptide I	1841	0.21
chr11_131780761_131781452	0.28	NTM	neurotrimin	209	0.95
chr4_81195528_81195918	0.27	FGF5	fibroblast growth factor 5	7930	0.26
chr2_102051443_102051701	0.27	RFX8	RFX family member 8, lacking RFX DNA binding domain	39165	0.16
chr12_118626563_118627015	0.27	TAOK3	TAO kinase 3	1538	0.42
chr17_78044749_78045392	0.27	CCDC40	coiled-coil domain containing 40	12346	0.15
chr1_164529222_164529675	0.27	PBX1	pre-B-cell leukemia homeobox 1	388	0.91
chr11_121800761_121801203	0.27	ENSG00000252556	.	74081	0.11
chr3_120149251_120149402	0.27	FSTL1	follistatin-like 1	20512	0.22
chr8_42054040_42054280	0.26	PLAT	plasminogen activator, tissue	944	0.52
chr2_200446222_200446758	0.26	SATB2	SATB homeobox 2	110501	0.07
chr7_39504844_39505021	0.26	POU6F2-AS1	POU6F2 antisense RNA 1	58987	0.12
chr7_41738474_41738677	0.26	INHBA	inhibin, beta A	1632	0.38
chr6_3324359_3324736	0.26	RP11-506K6.4		12651	0.23
chr1_150245669_150245859	0.26	C1orf54	chromosome 1 open reading frame 54	581	0.54
chr2_68953487_68953638	0.26	ARHGAP25	Rho GTPase activating protein 25	8351	0.26
chr11_124768607_124768899	0.26	ROBO4	roundabout, axon guidance receptor, homolog 4 (Drosophila)	576	0.61
chr7_27218725_27218915	0.26	RP1-170O19.20	Uncharacterized protein	812	0.27
chr3_49064758_49065280	0.26	IMPDH2	IMP (inosine 5'-monophosphate) dehydrogenase 2	887	0.3
chr4_128553582_128553997	0.25	INTU	inturned planar cell polarity protein	298	0.94
chr15_80696207_80696642	0.25	ARNT2	aryl-hydrocarbon receptor nuclear translocator 2	269	0.71
chr4_171010363_171010619	0.25	AADAT	aminoadipate aminotransferase	54	0.98
chr5_83680091_83680703	0.25	CTD-2269F5.1		23	0.71
chr12_71003154_71004126	0.24	PTPRB	protein tyrosine phosphatase, receptor type, B	16	0.99
chr1_94219763_94219914	0.24	RP11-488P3.1		21162	0.21
chr7_92327766_92328157	0.24	ENSG00000206763	.	3167	0.33
chr9_128288246_128288397	0.24	ENSG00000243845	.	12835	0.21
chr5_113697124_113698006	0.24	KCNN2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	451	0.9
chr13_24007498_24007984	0.24	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	100	0.98
chr8_108344303_108344567	0.24	ANGPT1	angiopoietin 1	4315	0.34
chr15_23743478_23743629	0.24	GOLGA6L2	golgin A6 family-like 2	51172	0.11
chr1_79471738_79472138	0.24	ELTD1	EGF, latrophilin and seven transmembrane domain containing 1	465	0.9
chr6_111738419_111738706	0.24	REV3L-IT1	REV3L intronic transcript 1 (non-protein coding)	55752	0.11
chr15_99847895_99848073	0.24	AC022819.2	Uncharacterized protein	11844	0.18
chr21_46573548_46573916	0.23	ADARB1	adenosine deaminase, RNA-specific, B1	17825	0.17
chr13_24006860_24007105	0.23	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	859	0.74
chr7_111724737_111724893	0.23	DOCK4	dedicator of cytokinesis 4	80629	0.1
chr15_48469342_48470564	0.23	MYEF2	myelin expression factor 2	597	0.66
chr5_67714061_67714212	0.23	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	125740	0.06
chr18_6729547_6730123	0.23	ARHGAP28	Rho GTPase activating protein 28	14	0.5
chr10_104536012_104536214	0.23	WBP1L	WW domain binding protein 1-like	107	0.96
chr1_33812781_33812932	0.23	PHC2	polyhomeotic homolog 2 (Drosophila)	2630	0.17
chr6_7692698_7692863	0.23	BMP6	bone morphogenetic protein 6	34250	0.21
chr2_238318512_238318719	0.23	COL6A3	collagen, type VI, alpha 3	4176	0.24
chr18_74333391_74333920	0.23	LINC00908	long intergenic non-protein coding RNA 908	92781	0.08
chr10_6962147_6962542	0.23	PRKCQ	protein kinase C, theta	340081	0.01
chr19_18497517_18497681	0.22	ENSG00000264175	.	227	0.74
chr4_124365503_124365798	0.22	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	44527	0.21
chr12_91721216_91721367	0.22	DCN	decorin	144391	0.05
chr11_64215600_64216212	0.22	AP003774.4	HCG1652096, isoform CRA_a; Uncharacterized protein; cDNA FLJ37045 fis, clone BRACE2012185	640	0.68
chr9_132246124_132246361	0.22	ENSG00000264298	.	5407	0.24
chr22_30640971_30641213	0.22	RP1-102K2.8		892	0.38
chr11_65639318_65639911	0.22	EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	511	0.56
chr7_90012947_90013805	0.22	CLDN12	claudin 12	341	0.9
chr8_2199973_2200269	0.22	MYOM2	myomesin 2	206937	0.03
chr7_95690232_95690383	0.22	ENSG00000208025	.	158761	0.04
chr4_86700210_86700446	0.22	ARHGAP24	Rho GTPase activating protein 24	469	0.88
chr20_23617810_23618640	0.22	CST3	cystatin C	357	0.87
chr7_82071524_82071810	0.22	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	1364	0.61
chr7_116661589_116661740	0.21	ST7	suppression of tumorigenicity 7	1333	0.44
chr5_158438402_158438767	0.21	CTD-2363C16.2		25770	0.2
chr15_52943999_52944218	0.21	FAM214A	family with sequence similarity 214, member A	139	0.95
chrX_78003533_78003765	0.21	LPAR4	lysophosphatidic acid receptor 4	421	0.91
chr15_77480576_77480727	0.21	PEAK1	pseudopodium-enriched atypical kinase 1	64222	0.12
chr10_77229198_77229525	0.21	RP11-399K21.10		38015	0.16
chr14_63671002_63671585	0.21	RHOJ	ras homolog family member J	167	0.97
chr19_36207272_36208543	0.21	KMT2B	Histone-lysine N-methyltransferase 2B	1014	0.26
chr3_152314332_152314547	0.21	RP11-362A9.3		99837	0.08
chr2_121499238_121499672	0.21	GLI2	GLI family zinc finger 2	5632	0.32
chr17_39861478_39861907	0.21	GAST	gastrin	6886	0.1
chr10_34630198_34630349	0.21	PARD3	par-3 family cell polarity regulator	31188	0.25
chr9_94183221_94183836	0.21	NFIL3	nuclear factor, interleukin 3 regulated	2616	0.4
chr22_46471692_46472277	0.21	FLJ27365	hsa-mir-4763	4208	0.11
chr3_175244326_175245006	0.21	ENSG00000201648	.	82601	0.1
chr2_189839524_189839773	0.21	COL3A1	collagen, type III, alpha 1	549	0.79
chr3_112358713_112358917	0.21	CCDC80	coiled-coil domain containing 80	1301	0.54
chr3_194840398_194840606	0.21	XXYLT1	xyloside xylosyltransferase 1	2419	0.23
chrX_3379202_3379389	0.21	ENSG00000212214	.	70997	0.11
chr8_25042452_25043634	0.20	DOCK5	dedicator of cytokinesis 5	663	0.75
chr22_45865037_45865472	0.20	RP1-102D24.5		20630	0.17
chr7_83768499_83768650	0.20	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	55643	0.18
chr6_56706635_56706858	0.20	DST	dystonin	1197	0.47
chr9_130639317_130639975	0.20	AK1	adenylate kinase 1	376	0.71
chr15_96883311_96883827	0.20	ENSG00000222651	.	7079	0.16
chr3_66139685_66140118	0.20	SLC25A26	solute carrier family 25 (S-adenosylmethionine carrier), member 26	20616	0.25
chr3_106064913_106065064	0.20	ENSG00000200610	.	169756	0.04
chr12_32687758_32688027	0.20	FGD4	FYVE, RhoGEF and PH domain containing 4	634	0.8
chr2_216299376_216299642	0.20	FN1	fibronectin 1	1281	0.4
chr1_162602563_162603214	0.20	DDR2	discoidin domain receptor tyrosine kinase 2	628	0.74
chr5_115961898_115962197	0.20	SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	51417	0.18
chr5_151060368_151060611	0.20	CTB-113P19.1		3955	0.17
chr2_189842191_189842342	0.20	ENSG00000221502	.	552	0.78
chr11_123059250_123059539	0.20	CTD-2216M2.1		116	0.97
chr8_87718795_87718946	0.20	RP11-386D6.1		905	0.65
chr2_188417302_188417453	0.20	AC007319.1		1499	0.38
chr17_48366854_48367409	0.20	RP11-893F2.9		1915	0.24
chr13_110958781_110959436	0.20	COL4A1	collagen, type IV, alpha 1	370	0.6
chr14_52121858_52122101	0.20	FRMD6	FERM domain containing 6	3281	0.25
chr1_54587067_54587332	0.20	AL161915.1	Uncharacterized protein	17231	0.13
chr7_27202641_27202952	0.20	HOXA9	homeobox A9	2349	0.09
chr15_42749089_42749416	0.20	ZNF106	zinc finger protein 106	459	0.78
chr17_19966866_19967068	0.20	SPECC1	sperm antigen with calponin homology and coiled-coil domains 1	23367	0.18
chr8_25946426_25946850	0.20	EBF2	early B-cell factor 2	43725	0.17
chr1_244609044_244609215	0.20	ADSS	adenylosuccinate synthase	6307	0.21
chr8_108507547_108507698	0.20	ANGPT1	angiopoietin 1	399	0.92
chr10_114714851_114715858	0.19	RP11-57H14.2		3720	0.26
chr9_18976648_18977105	0.19	FAM154A	family with sequence similarity 154, member A	56310	0.1
chr1_78356045_78356196	0.19	NEXN-AS1	NEXN antisense RNA 1	896	0.52
chr22_46423027_46423794	0.19	RP6-109B7.5		25563	0.09
chr7_94004298_94004620	0.19	COL1A2	collagen, type I, alpha 2	19414	0.26
chr8_117133283_117133521	0.19	ENSG00000221793	.	15596	0.28
chrX_103381032_103381192	0.19	SLC25A53	solute carrier family 25, member 53	20596	0.16
chr19_30865612_30866061	0.19	ZNF536	zinc finger protein 536	2517	0.44
chr6_143193241_143193570	0.19	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	35221	0.21
chr2_89180194_89180345	0.19	IGKV4-1	immunoglobulin kappa variable 4-1	4644	0.09
chr12_78336681_78336916	0.19	NAV3	neuron navigator 3	23258	0.28
chr10_62059868_62060258	0.19	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	177	0.97
chr1_68084153_68084510	0.19	ENSG00000242482	.	38481	0.16
chr14_85998039_85998552	0.19	FLRT2	fibronectin leucine rich transmembrane protein 2	1723	0.42
chr2_14633353_14633613	0.19	FAM84A	family with sequence similarity 84, member A	139327	0.05
chr11_8740394_8740932	0.19	ST5	suppression of tumorigenicity 5	27	0.96
chr5_15500636_15500842	0.19	FBXL7	F-box and leucine-rich repeat protein 7	434	0.91
chr2_66663002_66663153	0.19	MEIS1	Meis homeobox 1	387	0.81
chr16_53244996_53245358	0.19	CHD9	chromodomain helicase DNA binding protein 9	2814	0.29
chr2_144303459_144303649	0.19	RP11-570L15.2		26120	0.19
chr6_76059036_76059425	0.19	RP11-415D17.3		7700	0.18
chr17_47077080_47077320	0.19	IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	2092	0.16
chr1_201619186_201619405	0.19	NAV1	neuron navigator 1	1845	0.29
chr12_105627028_105627183	0.19	APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	123	0.97
chr13_110954925_110955076	0.19	COL4A2	collagen, type IV, alpha 2	3159	0.28
chr2_188269361_188269539	0.19	CALCRL	calcitonin receptor-like	43529	0.19
chr12_63254560_63254711	0.19	ENSG00000200296	.	9954	0.25
chr9_114671696_114672066	0.19	UGCG	UDP-glucose ceramide glucosyltransferase	12835	0.19
chrX_106898289_106898771	0.19	PRPS1	phosphoribosyl pyrophosphate synthetase 1	15942	0.22
chr12_69809879_69810030	0.19	ENSG00000266185	.	15271	0.18
chr1_172154318_172154604	0.18	DNM3OS	DNM3 opposite strand/antisense RNA	40527	0.14
chrX_110038687_110039773	0.18	CHRDL1	chordin-like 1	56	0.99
chr8_132929065_132929278	0.18	EFR3A	EFR3 homolog A (S. cerevisiae)	12815	0.3
chr10_30346002_30346153	0.18	KIAA1462	KIAA1462	2376	0.44
chr15_34531260_34531657	0.18	EMC4	ER membrane protein complex subunit 4	11562	0.14
chr15_93258311_93258462	0.18	FAM174B	family with sequence similarity 174, member B	47113	0.14
chr3_16217443_16217716	0.18	GALNT15	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15	1363	0.53
chr7_158314531_158314682	0.18	ENSG00000207637	.	10899	0.17
chr17_42544837_42545068	0.18	GPATCH8	G patch domain containing 8	35807	0.12
chr12_115889459_115889637	0.18	RP11-116D17.1	HCG2038717; Uncharacterized protein	88731	0.1
chr13_38171648_38172094	0.18	POSTN	periostin, osteoblast specific factor	992	0.71
chr2_202901871_202902113	0.18	FZD7	frizzled family receptor 7	2682	0.25
chr20_11871763_11872529	0.18	BTBD3	BTB (POZ) domain containing 3	171	0.97
chrX_49801111_49801262	0.18	ENSG00000272080	.	21980	0.08
chr15_92104669_92104931	0.18	ENSG00000238981	.	273809	0.01
chr17_40284922_40285123	0.18	RAB5C	RAB5C, member RAS oncogene family	3427	0.12
chr17_38440207_38440497	0.18	CDC6	cell division cycle 6	3533	0.16
chr4_159093168_159093728	0.18	RP11-597D13.9		281	0.64
chr2_232545912_232546437	0.18	MGC4771		25447	0.14
chr10_113962747_113962898	0.18	GPAM	glycerol-3-phosphate acyltransferase, mitochondrial	19297	0.25
chr15_61327175_61327382	0.18	RP11-39M21.1		146170	0.04
chr15_37180001_37180243	0.18	ENSG00000212511	.	35281	0.22
chr9_20725861_20726160	0.18	ENSG00000207609	.	9906	0.2
chr3_114788095_114788246	0.18	ZBTB20	zinc finger and BTB domain containing 20	2052	0.5
chr5_86264086_86264257	0.18	ENSG00000251951	.	134492	0.05
chr8_131960988_131961496	0.18	RP11-737F9.1		13587	0.24
chr5_39421621_39421795	0.18	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	3262	0.35
chr4_143273250_143273504	0.18	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	46280	0.21
chr9_113940701_113941000	0.18	ENSG00000212409	.	81157	0.1
chr22_17679684_17679946	0.18	CECR1	cat eye syndrome chromosome region, candidate 1	858	0.6
chrX_129473317_129474471	0.18	SLC25A14	solute carrier family 25 (mitochondrial carrier, brain), member 14	7	0.98
chr8_141248678_141248836	0.18	TRAPPC9	trafficking protein particle complex 9	212272	0.02
chr7_137028027_137028276	0.18	PTN	pleiotrophin	369	0.92
chr18_52942632_52942783	0.18	TCF4	transcription factor 4	195	0.97
chr1_17866390_17866720	0.18	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	225	0.95
chrX_84499187_84500398	0.18	ZNF711	zinc finger protein 711	21	0.94
chr8_55294582_55295235	0.18	ENSG00000244107	.	38120	0.17
chr10_30872530_30872876	0.17	ENSG00000239744	.	27870	0.19
chrX_69674453_69675874	0.17	DLG3	discs, large homolog 3 (Drosophila)	217	0.75
chr13_101527616_101527852	0.17	NALCN-AS1	NALCN antisense RNA 1	167155	0.04
chr11_16023597_16024065	0.17	CTD-3096P4.1		20905	0.28
chr4_26022444_26022665	0.17	SMIM20	small integral membrane protein 20	106623	0.07
chr18_9701912_9702261	0.17	RAB31	RAB31, member RAS oncogene family	6076	0.24
chr12_27398836_27399341	0.17	STK38L	serine/threonine kinase 38 like	498	0.86
chr1_56943161_56943502	0.17	ENSG00000223307	.	100241	0.08
chr16_17547681_17547832	0.17	XYLT1	xylosyltransferase I	16982	0.31
chr9_14353312_14353885	0.17	RP11-120J1.1		6279	0.28
chr2_225847014_225847203	0.17	ENSG00000263828	.	28149	0.22
chr17_60868253_60868692	0.17	MARCH10	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	15529	0.23
chr4_184264353_184264576	0.17	ENSG00000238596	.	14013	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX6

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.1	0.4	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1	0.4	GO:0070208	protein heterotrimerization(GO:0070208)
0.1	0.3	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.3	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.3	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.1	0.3	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1	0.2	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.3	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.3	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.4	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.1	0.2	GO:0021508	floor plate formation(GO:0021508)
0.1	0.2	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.3	GO:0048149	behavioral response to ethanol(GO:0048149)
0.1	0.2	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.1	0.2	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.1	0.2	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1	0.2	GO:0022605	oogenesis stage(GO:0022605)
0.1	0.5	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.1	0.2	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.1	0.1	GO:0060437	lung growth(GO:0060437)
0.1	0.5	GO:0060216	definitive hemopoiesis(GO:0060216)
0.1	0.2	GO:0008354	germ cell migration(GO:0008354)
0.1	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.2	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.1	0.2	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.2	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:0090083	regulation of inclusion body assembly(GO:0090083)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.2	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.2	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0048343	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0	0.1	GO:0010159	specification of organ position(GO:0010159)
0.0	0.3	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.2	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0003136	negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.0	0.4	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.2	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.1	GO:0051284	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.2	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.2	GO:0097435	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.2	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.2	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.3	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.1	GO:0032347	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0036303	lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0	0.1	GO:0019511	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.2	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.2	GO:0060039	pericardium development(GO:0060039)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.0	GO:0010613	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.3	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.4	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.0	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.0	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.0	0.1	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.1	GO:0090009	primitive streak formation(GO:0090009)
0.0	0.0	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.0	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.2	GO:0007263	nitric oxide mediated signal transduction(GO:0007263)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.5	GO:0008038	neuron recognition(GO:0008038)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0032224	positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0048333	mesodermal cell differentiation(GO:0048333)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.0	GO:0021794	thalamus development(GO:0021794)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0060251	regulation of glial cell proliferation(GO:0060251)
0.0	0.2	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.1	GO:0010799	regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0	0.1	GO:0045064	T-helper 2 cell differentiation(GO:0045064)
0.0	0.2	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.1	GO:1901532	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.1	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.0	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.0	GO:0061140	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510) lung secretory cell differentiation(GO:0061140)
0.0	0.1	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.1	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.1	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.1	GO:0071800	podosome assembly(GO:0071800)
0.0	0.0	GO:0050961	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.1	GO:0009109	coenzyme catabolic process(GO:0009109)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.4	GO:0051925	obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0	0.3	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.0	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0033240	positive regulation of cellular amine metabolic process(GO:0033240)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.3	GO:0030032	lamellipodium assembly(GO:0030032)
0.0	0.0	GO:0072176	nephric duct development(GO:0072176)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0071398	cellular response to fatty acid(GO:0071398)
0.0	0.1	GO:0042640	anagen(GO:0042640)
0.0	0.0	GO:0031223	response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0	0.0	GO:0051461	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0048712	negative regulation of astrocyte differentiation(GO:0048712)
0.0	0.1	GO:0035307	positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.0	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.0	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.0	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.0	GO:0090190	positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0	0.0	GO:0045617	negative regulation of epidermal cell differentiation(GO:0045605) negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.1	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.1	GO:0042474	middle ear morphogenesis(GO:0042474)
0.0	0.3	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.4	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.0	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.0	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0008347	glial cell migration(GO:0008347)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.2	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.0	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.0	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.0	0.1	GO:0043113	receptor clustering(GO:0043113)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.0	GO:0003157	endocardium development(GO:0003157) endocardium morphogenesis(GO:0003160) endocardium formation(GO:0060214)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.2	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0030539	male genitalia development(GO:0030539)
0.0	0.1	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0060900	optic cup morphogenesis involved in camera-type eye development(GO:0002072) embryonic camera-type eye formation(GO:0060900)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.0	GO:0046022	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.2	GO:0001893	maternal placenta development(GO:0001893)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.2	GO:0043403	skeletal muscle tissue regeneration(GO:0043403)
0.0	0.0	GO:0072191	positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193) kidney smooth muscle tissue development(GO:0072194)
0.0	0.0	GO:0036445	neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0016265	obsolete death(GO:0016265)
0.0	0.0	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0009264	deoxyribonucleotide catabolic process(GO:0009264) deoxyribose phosphate catabolic process(GO:0046386)
0.0	0.0	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.0	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.0	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.0	GO:0007494	midgut development(GO:0007494)
0.0	0.0	GO:0015811	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.1	GO:0044091	membrane biogenesis(GO:0044091)
0.0	0.0	GO:2000909	regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.0	0.0	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.0	GO:1903020	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0002076	osteoblast development(GO:0002076)
0.0	0.1	GO:0007184	SMAD protein import into nucleus(GO:0007184)
0.0	0.1	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	0.0	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.0	GO:0097094	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.2	GO:0048009	insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0	0.1	GO:0035437	protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0008356	asymmetric cell division(GO:0008356)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0070852	cell body fiber(GO:0070852)
0.1	0.4	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	0.3	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.8	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	0.4	GO:0005587	collagen type IV trimer(GO:0005587)
0.1	0.3	GO:0001527	microfibril(GO:0001527)
0.1	0.2	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.0	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.0	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.0	0.3	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.2	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.2	GO:0016342	catenin complex(GO:0016342)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.2	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.7	GO:0005902	microvillus(GO:0005902)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0000801	central element(GO:0000801)
0.0	1.2	GO:0030426	growth cone(GO:0030426)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.5	GO:0034704	calcium channel complex(GO:0034704)
0.0	0.5	GO:0030018	Z disc(GO:0030018)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.3	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.0	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.7	GO:0005604	basement membrane(GO:0005604)
0.0	0.2	GO:0005581	collagen trimer(GO:0005581)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0098878	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.0	GO:0043205	fibril(GO:0043205)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.3	GO:0070052	collagen V binding(GO:0070052)
0.1	0.2	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.9	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	0.6	GO:0070628	proteasome binding(GO:0070628)
0.1	0.2	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.3	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.2	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	0.2	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.2	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.3	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.2	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.2	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.2	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.2	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.2	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.8	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.3	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.2	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.4	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.2	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.3	GO:0019894	kinesin binding(GO:0019894)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.0	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.2	GO:0043394	proteoglycan binding(GO:0043394)
0.0	0.4	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.2	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	1.2	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.4	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.0	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.1	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.0	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.2	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.3	GO:0030971	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0	0.2	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.1	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0032052	bile acid binding(GO:0032052)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.0	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.1	GO:0015368	calcium:cation antiporter activity(GO:0015368)
0.0	0.5	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.0	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
0.0	0.0	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.6	GO:0051015	actin filament binding(GO:0051015)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.2	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.0	GO:0015168	glycerol transmembrane transporter activity(GO:0015168)
0.0	0.0	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.0	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.2	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.2	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	1.9	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.0	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	0.6	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.6	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.3	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.3	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.3	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.2	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.4	PID FGF PATHWAY	FGF signaling pathway
0.0	0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.1	0.1	REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	Genes involved in p53-Independent G1/S DNA damage checkpoint
0.1	1.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	1.2	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.3	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.5	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.3	REACTOME ACTIVATED POINT MUTANTS OF FGFR2	Genes involved in Activated point mutants of FGFR2
0.0	0.3	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.2	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.0	0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.1	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR