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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SOX9

Z-value: 0.55

Motif logo

Transcription factors associated with SOX9

Gene Symbol	Gene ID	Gene Info
SOX9 Ensembl NCBI GeneCards UniProt	ENSG00000125398.5	SOX9

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SOX9	chr17_70117705_70117946	664	0.821863	-0.68	4.6e-02	Click!
SOX9	chr17_70118144_70118357	1089	0.670792	-0.67	4.7e-02	Click!
SOX9	chr17_70358322_70358473	241236	0.019037	-0.62	7.3e-02	Click!
SOX9	chr17_70113280_70113463	3790	0.358750	-0.61	7.8e-02	Click!
SOX9	chr17_70269373_70269524	152287	0.043999	-0.61	8.0e-02	Click!

Activity of the SOX9 motif across conditions

Conditions sorted by the z-value of the SOX9 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr21_15917471_15917848	0.46	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	1003	0.63
chr2_65245033_65245279	0.36	AC007386.4		19475	0.14
chr15_86098904_86099149	0.31	AKAP13	A kinase (PRKA) anchor protein 13	349	0.88
chr15_50411579_50411857	0.30	ATP8B4	ATPase, class I, type 8B, member 4	299	0.92
chr1_212428535_212428756	0.29	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	30234	0.16
chr12_10282570_10282865	0.29	CLEC7A	C-type lectin domain family 7, member A	35	0.96
chr13_114823175_114823405	0.27	RASA3	RAS p21 protein activator 3	20148	0.23
chr12_54891563_54891796	0.27	NCKAP1L	NCK-associated protein 1-like	184	0.93
chr11_64215600_64216212	0.26	AP003774.4	HCG1652096, isoform CRA_a; Uncharacterized protein; cDNA FLJ37045 fis, clone BRACE2012185	640	0.68
chr22_17305454_17306380	0.25	HSFY1P1	heat shock transcription factor, Y-linked 1 pseudogene 1	2524	0.24
chr2_103034578_103034791	0.24	IL18RAP	interleukin 18 receptor accessory protein	465	0.76
chrX_47489873_47490024	0.23	CFP	complement factor properdin	244	0.88
chr21_36881240_36881456	0.23	ENSG00000211590	.	211665	0.02
chr22_50242150_50242826	0.22	ZBED4	zinc finger, BED-type containing 4	5002	0.2
chr12_49616622_49616880	0.22	TUBA1C	tubulin, alpha 1c	4958	0.14
chr8_145086794_145086945	0.22	PARP10	poly (ADP-ribose) polymerase family, member 10	71	0.74
chr10_135091510_135091693	0.21	ADAM8	ADAM metallopeptidase domain 8	1229	0.29
chr10_111783224_111783375	0.21	ADD3	adducin 3 (gamma)	15577	0.2
chr15_94866308_94866459	0.21	MCTP2	multiple C2 domains, transmembrane 2	24888	0.28
chr6_10598498_10598818	0.20	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	12679	0.17
chr15_85315766_85316058	0.20	ZNF592	zinc finger protein 592	9973	0.14
chr9_93558631_93558871	0.19	SYK	spleen tyrosine kinase	5318	0.35
chr8_90789610_90789761	0.19	RIPK2	receptor-interacting serine-threonine kinase 2	19623	0.27
chr11_9271619_9271993	0.19	RP11-5L12.1		4750	0.21
chr14_23218066_23218219	0.19	ENSG00000212302	.	7896	0.12
chr4_139219992_139220143	0.18	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	56564	0.17
chr12_95043269_95044318	0.18	TMCC3	transmembrane and coiled-coil domain family 3	545	0.85
chr6_114178016_114178613	0.18	MARCKS	myristoylated alanine-rich protein kinase C substrate	227	0.93
chr1_211780463_211780858	0.18	RP11-359E8.5		23593	0.15
chr5_39177582_39177762	0.18	FYB	FYN binding protein	25457	0.23
chr18_2653530_2653681	0.18	SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	2132	0.25
chrX_44203680_44203969	0.18	EFHC2	EF-hand domain (C-terminal) containing 2	906	0.71
chr2_135070643_135070794	0.18	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	58888	0.15
chr8_131004829_131004980	0.17	ENSG00000253043	.	11943	0.17
chr9_135855020_135855171	0.17	GFI1B	growth factor independent 1B transcription repressor	997	0.42
chr3_186250449_186250600	0.17	CRYGS	crystallin, gamma S	11716	0.17
chr1_161578680_161578831	0.17	FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	13412	0.11
chr17_29639732_29640055	0.17	EVI2B	ecotropic viral integration site 2B	1209	0.36
chr16_81852082_81852236	0.17	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	39296	0.2
chr15_101783225_101783409	0.17	CHSY1	chondroitin sulfate synthase 1	8820	0.18
chr5_55711467_55711618	0.17	ENSG00000265665	.	41423	0.16
chr2_143829142_143829293	0.16	ARHGAP15	Rho GTPase activating protein 15	19714	0.25
chr1_110429914_110430065	0.16	RP11-195M16.1		1103	0.5
chr4_6940579_6940730	0.16	ENSG00000265953	.	14362	0.15
chr19_36444792_36444943	0.16	LRFN3	leucine rich repeat and fibronectin type III domain containing 3	16845	0.09
chr5_70316349_70316527	0.16	NAIP	NLR family, apoptosis inhibitory protein	99	0.98
chr5_17255187_17255338	0.16	ENSG00000252908	.	14542	0.19
chr5_68902997_68903156	0.16	RP11-848G14.2		11064	0.18
chr1_153363978_153364129	0.16	S100A8	S100 calcium binding protein A8	389	0.76
chr12_10096266_10096511	0.16	CLEC12A	C-type lectin domain family 12, member A	7527	0.14
chr19_28271110_28271360	0.16	AC005758.1		138616	0.05
chr12_116510107_116510258	0.16	ENSG00000200665	.	10193	0.25
chr17_10102219_10102533	0.16	GAS7	growth arrest-specific 7	508	0.83
chr5_69758153_69758307	0.16	RP11-497H16.7		11045	0.27
chr12_110517460_110517751	0.16	C12orf76	chromosome 12 open reading frame 76	6114	0.22
chr13_41752294_41752445	0.16	ENSG00000238651	.	1854	0.3
chr8_61821706_61823076	0.16	RP11-33I11.2		100226	0.08
chr21_45509829_45509980	0.16	PWP2	PWP2 periodic tryptophan protein homolog (yeast)	17267	0.16
chr17_57789761_57790061	0.15	VMP1	vacuole membrane protein 1	4828	0.18
chr14_38548074_38548225	0.15	CTD-2058B24.2		12214	0.26
chr6_109699129_109699388	0.15	CD164	CD164 molecule, sialomucin	3645	0.18
chr7_134846065_134846216	0.15	RP11-134L10.1		7015	0.14
chr6_6687519_6687926	0.15	LY86-AS1	LY86 antisense RNA 1	64718	0.14
chr12_10019991_10020525	0.15	RP11-290C10.1		632	0.61
chr19_54345711_54345913	0.15	NLRP12	NLR family, pyrin domain containing 12	18164	0.05
chr13_49478658_49478809	0.15	ENSG00000265585	.	25615	0.21
chr1_192905339_192905490	0.15	ENSG00000223075	.	60299	0.12
chr4_141015619_141015856	0.15	RP11-392B6.1		33432	0.2
chr10_131555449_131556065	0.15	RP11-109A6.2		55936	0.14
chr7_33089731_33090334	0.15	ENSG00000241420	.	4330	0.18
chr1_160673796_160673952	0.14	CD48	CD48 molecule	7719	0.16
chr1_235115156_235115307	0.14	ENSG00000239690	.	75298	0.1
chr2_121354385_121354536	0.14	ENSG00000201006	.	54389	0.16
chr7_2570576_2570806	0.14	ENSG00000264357	.	3983	0.17
chr1_221204797_221204948	0.14	HLX	H2.0-like homeobox	150288	0.04
chr11_61738714_61739353	0.14	AP003733.1	Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801	3580	0.16
chr2_135051726_135051877	0.14	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	39971	0.19
chrX_20132855_20133006	0.14	MAP7D2	MAP7 domain containing 2	1820	0.28
chr6_64062151_64062302	0.14	LGSN	lengsin, lens protein with glutamine synthetase domain	32344	0.24
chr6_24932242_24932425	0.14	FAM65B	family with sequence similarity 65, member B	3855	0.28
chr5_14560333_14560610	0.14	FAM105A	family with sequence similarity 105, member A	21413	0.23
chr20_44689695_44689846	0.14	NCOA5	nuclear receptor coactivator 5	28821	0.11
chr3_13002263_13002414	0.14	IQSEC1	IQ motif and Sec7 domain 1	6830	0.26
chr7_112062054_112062259	0.14	IFRD1	interferon-related developmental regulator 1	867	0.64
chr4_55534639_55534790	0.13	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	10629	0.31
chr4_141174038_141174780	0.13	SCOC	short coiled-coil protein	4031	0.26
chr9_84494361_84494512	0.13	ENSG00000252167	.	5975	0.17
chr3_63793614_63793765	0.13	AC136289.1		2920	0.24
chrX_135961684_135962842	0.13	RBMX	RNA binding motif protein, X-linked	621	0.53
chr20_39657787_39658990	0.13	TOP1	topoisomerase (DNA) I	930	0.61
chr1_16160235_16160851	0.13	RP11-169K16.9		1812	0.28
chr17_73774322_73775453	0.13	H3F3B	H3 histone, family 3B (H3.3B)	480	0.64
chr5_134761710_134761905	0.13	C5orf20	chromosome 5 open reading frame 20	21231	0.12
chr7_140615501_140615652	0.13	BRAF	v-raf murine sarcoma viral oncogene homolog B	8988	0.22
chr10_3527831_3528010	0.13	RP11-184A2.3		265339	0.02
chr1_3527588_3528047	0.13	MEGF6	multiple EGF-like-domains 6	242	0.89
chr1_204940483_204940634	0.13	NFASC	neurofascin	10426	0.21
chr6_105153386_105153605	0.13	ENSG00000252944	.	61202	0.13
chr9_297994_298145	0.13	DOCK8	dedicator of cytokinesis 8	24999	0.18
chr15_93426669_93427240	0.12	CHD2	chromodomain helicase DNA binding protein 2	428	0.83
chr20_48887078_48887229	0.12	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	79777	0.09
chr7_105998110_105998261	0.12	NAMPT	nicotinamide phosphoribosyltransferase	71413	0.11
chr17_66433856_66434617	0.12	WIPI1	WD repeat domain, phosphoinositide interacting 1	4524	0.23
chr2_68953487_68953638	0.12	ARHGAP25	Rho GTPase activating protein 25	8351	0.26
chrX_135738768_135738919	0.12	CD40LG	CD40 ligand	8457	0.18
chr12_93163278_93163429	0.12	PLEKHG7	pleckstrin homology domain containing, family G (with RhoGef domain) member 7	33042	0.18
chr1_161600101_161600252	0.12	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	646	0.42
chr3_46970853_46971178	0.12	PTH1R	parathyroid hormone 1 receptor	26926	0.13
chr14_24641513_24641917	0.12	REC8	REC8 meiotic recombination protein	105	0.89
chr11_65378670_65378821	0.12	MAP3K11	mitogen-activated protein kinase kinase kinase 11	27	0.93
chr12_57870819_57871184	0.12	ARHGAP9	Rho GTPase activating protein 9	566	0.53
chr22_36632572_36632723	0.12	APOL2	apolipoprotein L, 2	2626	0.25
chr12_121676925_121677077	0.12	CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	21344	0.16
chr3_184395596_184395747	0.12	MAGEF1	melanoma antigen family F, 1	34165	0.19
chr3_36937026_36937306	0.12	TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	36792	0.17
chr2_169940004_169940155	0.12	DHRS9	dehydrogenase/reductase (SDR family) member 9	2462	0.31
chr13_31943501_31943652	0.12	B3GALTL	beta 1,3-galactosyltransferase-like	169503	0.04
chr4_153600093_153601094	0.12	TMEM154	transmembrane protein 154	571	0.78
chr7_104584020_104584171	0.12	ENSG00000251911	.	27639	0.16
chr1_150550029_150550609	0.11	MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	1687	0.18
chr3_152939222_152939486	0.11	ENSG00000265813	.	21548	0.22
chr18_9701912_9702261	0.11	RAB31	RAB31, member RAS oncogene family	6076	0.24
chr18_2960483_2961188	0.11	RP11-737O24.1		6181	0.16
chr5_77807061_77807212	0.11	LHFPL2	lipoma HMGIC fusion partner-like 2	37838	0.21
chr12_80321477_80321628	0.11	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	6943	0.2
chr13_77324135_77324286	0.11	KCTD12	potassium channel tetramerization domain containing 12	136315	0.05
chr5_37317955_37318106	0.11	ENSG00000251880	.	9207	0.22
chr6_39282333_39282484	0.11	KCNK17	potassium channel, subfamily K, member 17	79	0.98
chr17_27256722_27256873	0.11	PHF12	PHD finger protein 12	1489	0.19
chr6_89754695_89754846	0.11	ENSG00000223001	.	18639	0.15
chr11_82608630_82608781	0.11	C11orf82	chromosome 11 open reading frame 82	2312	0.28
chr11_48088687_48088966	0.11	ENSG00000263693	.	29508	0.17
chr7_5710794_5710945	0.11	RNF216-IT1	RNF216 intronic transcript 1 (non-protein coding)	9223	0.21
chr4_88896230_88897032	0.11	SPP1	secreted phosphoprotein 1	188	0.95
chr2_223536011_223536232	0.11	MOGAT1	monoacylglycerol O-acyltransferase 1	384	0.86
chr10_81947502_81948014	0.11	ANXA11	annexin A11	14981	0.2
chr19_16482667_16482930	0.11	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	10034	0.15
chr18_379614_379765	0.11	RP11-720L2.2		44727	0.16
chr15_99074007_99074158	0.11	FAM169B	family with sequence similarity 169, member B	16471	0.27
chr2_192604587_192604738	0.11	AC098872.3		53489	0.14
chr5_119593776_119593927	0.11	ENSG00000251975	.	79497	0.12
chr14_64806720_64806871	0.11	RP11-544I20.2		1478	0.34
chr16_27301591_27301742	0.11	NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	21551	0.15
chr12_805861_806012	0.11	NINJ2	ninjurin 2	32991	0.15
chr9_7653385_7653536	0.11	TMEM261	transmembrane protein 261	146607	0.05
chr5_126147731_126147991	0.11	LMNB1	lamin B1	34980	0.19
chr7_143080537_143080688	0.10	ZYX	zyxin	519	0.65
chr1_61543284_61543773	0.10	NFIA	nuclear factor I/A	582	0.78
chr2_201987013_201987300	0.10	CFLAR	CASP8 and FADD-like apoptosis regulator	44	0.96
chr12_110562218_110563151	0.10	IFT81	intraflagellar transport 81 homolog (Chlamydomonas)	487	0.84
chr21_34602307_34603720	0.10	IFNAR2	interferon (alpha, beta and omega) receptor 2	299	0.87
chr20_8583214_8583783	0.10	ENSG00000221201	.	6329	0.25
chr1_183556161_183556312	0.10	NCF2	neutrophil cytosolic factor 2	3480	0.25
chr15_92012895_92013046	0.10	SV2B	synaptic vesicle glycoprotein 2B	243870	0.02
chr8_70650371_70650522	0.10	RP11-102F4.2		24821	0.19
chr7_23246593_23246744	0.10	NUPL2	nucleoporin like 2	24985	0.16
chr6_42537305_42537764	0.10	UBR2	ubiquitin protein ligase E3 component n-recognin 2	5734	0.24
chr17_68678856_68679007	0.10	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	513255	0.0
chr8_90995843_90996298	0.10	NBN	nibrin	395	0.87
chr4_6909699_6909850	0.10	TBC1D14	TBC1 domain family, member 14	1195	0.49
chr20_45028360_45028511	0.10	ELMO2	engulfment and cell motility 2	5314	0.24
chr11_94335838_94335989	0.10	PIWIL4	piwi-like RNA-mediated gene silencing 4	15042	0.2
chr8_27141347_27141498	0.10	TRIM35	tripartite motif containing 35	10230	0.19
chr13_48809687_48810120	0.10	ITM2B	integral membrane protein 2B	2564	0.37
chr2_33355355_33355506	0.10	LTBP1	latent transforming growth factor beta binding protein 1	4043	0.34
chr11_93451363_93451537	0.10	ENSG00000199875	.	1319	0.18
chr15_92404035_92404308	0.10	SLCO3A1	solute carrier organic anion transporter family, member 3A1	6820	0.27
chr7_155484798_155484949	0.10	RBM33	RNA binding motif protein 33	8712	0.25
chr6_138176930_138177081	0.10	RP11-356I2.4		2180	0.35
chr10_102106243_102106464	0.10	RP11-34D15.2		206	0.76
chr1_164489142_164489293	0.10	PBX1	pre-B-cell leukemia homeobox 1	39220	0.2
chr1_29241076_29241272	0.10	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	83	0.97
chr2_218990770_218991030	0.10	CXCR2	chemokine (C-X-C motif) receptor 2	158	0.95
chr2_48338474_48339359	0.10	ENSG00000201010	.	105798	0.07
chr1_21503574_21503811	0.10	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	315	0.69
chr4_79583127_79583675	0.10	ENSG00000238816	.	22147	0.19
chr1_207495975_207496182	0.10	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	942	0.68
chr12_40547331_40547482	0.10	LRRK2	leucine-rich repeat kinase 2	43140	0.16
chr19_23427286_23427437	0.09	ZNF724P	zinc finger protein 724, pseudogene	5801	0.26
chr18_72163609_72164283	0.09	CNDP2	CNDP dipeptidase 2 (metallopeptidase M20 family)	328	0.9
chr21_37557715_37557866	0.09	DOPEY2	dopey family member 2	20957	0.12
chr1_200335563_200335714	0.09	ZNF281	zinc finger protein 281	43482	0.2
chr5_98265881_98266063	0.09	CHD1	chromodomain helicase DNA binding protein 1	3732	0.25
chr5_1501228_1501379	0.09	LPCAT1	lysophosphatidylcholine acyltransferase 1	22789	0.19
chrX_119737965_119739054	0.09	MCTS1	malignant T cell amplified sequence 1	333	0.88
chr14_92942291_92942442	0.09	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	36658	0.18
chr3_119814638_119815091	0.09	GSK3B	glycogen synthase kinase 3 beta	1600	0.39
chr4_10642308_10642459	0.09	CLNK	cytokine-dependent hematopoietic cell linker	15802	0.3
chr2_70474548_70475674	0.09	TIA1	TIA1 cytotoxic granule-associated RNA binding protein	475	0.73
chr10_90593785_90593936	0.09	ANKRD22	ankyrin repeat domain 22	17715	0.16
chr2_143909648_143909799	0.09	RP11-190J23.1		20018	0.22
chr12_32740907_32741058	0.09	FGD4	FYVE, RhoGEF and PH domain containing 4	10478	0.26
chr9_108104857_108105008	0.09	SLC44A1	solute carrier family 44 (choline transporter), member 1	12825	0.28
chr16_17547681_17547832	0.09	XYLT1	xylosyltransferase I	16982	0.31
chr16_30103433_30103902	0.09	TBX6	T-box 6	459	0.59
chr8_38325453_38326142	0.09	FGFR1	fibroblast growth factor receptor 1	337	0.87
chr10_49922246_49922397	0.09	WDFY4	WDFY family member 4	4570	0.28
chr1_84610970_84611403	0.09	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	1232	0.6
chr6_53130180_53130331	0.09	ENSG00000264056	.	11536	0.19
chr9_117721707_117721858	0.09	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	29085	0.23

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX9

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.1	0.2	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:2000380	regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:0032328	alanine transport(GO:0032328)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.0	GO:0042663	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0007141	male meiosis I(GO:0007141)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0001878	response to yeast(GO:0001878)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0000239	pachytene(GO:0000239)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.0	GO:1904019	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.0	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.1	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.0	GO:0014041	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.0	GO:0032070	regulation of deoxyribonuclease activity(GO:0032070)
0.0	0.0	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0002544	chronic inflammatory response(GO:0002544)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.1	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0000800	lateral element(GO:0000800)
0.0	0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.2	GO:0043073	germ cell nucleus(GO:0043073)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.0	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0008091	spectrin(GO:0008091)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001846	opsonin binding(GO:0001846)
0.1	0.4	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.3	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.2	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.0	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0004339	glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.0	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.0	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.0	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.3	GO:0030295	protein kinase activator activity(GO:0030295)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.4	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.5	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK