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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SPDEF

Z-value: 0.25

Motif logo

Transcription factors associated with SPDEF

Gene Symbol	Gene ID	Gene Info
SPDEF Ensembl NCBI GeneCards UniProt	ENSG00000124664.6	SPDEF

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SPDEF	chr6_34544180_34544427	20193	0.175331	-0.26	5.0e-01	Click!

Activity of the SPDEF motif across conditions

Conditions sorted by the z-value of the SPDEF motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_160616915_160617313	0.20	SLAMF1	signaling lymphocytic activation molecule family member 1	29	0.97
chr14_25143618_25143855	0.13	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	40263	0.14
chr17_76129934_76130268	0.11	TMC6	transmembrane channel-like 6	1613	0.24
chr4_38806937_38807296	0.10	TLR1	toll-like receptor 1	83	0.97
chr15_101061059_101061210	0.10	CERS3	ceramide synthase 3	23342	0.14
chr19_18287388_18287660	0.09	IFI30	interferon, gamma-inducible protein 30	3047	0.14
chr10_30994119_30994515	0.08	SVILP1	supervillin pseudogene 1	9467	0.26
chr16_27378896_27379134	0.07	IL4R	interleukin 4 receptor	15019	0.19
chr12_133052078_133052229	0.07	MUC8	mucin 8	1427	0.44
chr11_119600715_119600866	0.07	CTD-2523D13.2		497	0.68
chr17_45356556_45356707	0.07	ENSG00000238419	.	19845	0.12
chr19_35949823_35949974	0.07	FFAR2	free fatty acid receptor 2	9281	0.11
chr12_53496670_53496821	0.06	SOAT2	sterol O-acyltransferase 2	557	0.63
chr16_11654733_11655066	0.06	LITAF	lipopolysaccharide-induced TNF factor	25330	0.15
chr14_24615202_24615772	0.05	PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	36	0.82
chr18_43266884_43267229	0.05	SLC14A2	solute carrier family 14 (urea transporter), member 2	20949	0.17
chr21_16424536_16424754	0.05	NRIP1	nuclear receptor interacting protein 1	12481	0.26
chrX_134429275_134429737	0.05	ZNF75D	zinc finger protein 75D	453	0.86
chr6_31794829_31795180	0.05	HSPA1B	heat shock 70kDa protein 1B	508	0.47
chr21_40734232_40734404	0.05	HMGN1	high mobility group nucleosome binding domain 1	12745	0.12
chr20_62198919_62199070	0.05	HELZ2	helicase with zinc finger 2, transcriptional coactivator	433	0.7
chr20_25038810_25039334	0.05	ACSS1	acyl-CoA synthetase short-chain family member 1	254	0.93
chr8_1954691_1954842	0.05	KBTBD11	kelch repeat and BTB (POZ) domain containing 11	32722	0.19
chrX_13161411_13161562	0.05	FAM9C	family with sequence similarity 9, member C	98685	0.08
chr6_35279100_35279566	0.05	DEF6	differentially expressed in FDCP 6 homolog (mouse)	1818	0.34
chr2_99349001_99349152	0.05	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	1487	0.47
chr19_10676975_10677686	0.04	KRI1	KRI1 homolog (S. cerevisiae)	617	0.51
chr5_60922081_60922360	0.04	C5orf64	chromosome 5 open reading frame 64	11416	0.22
chr7_156811762_156812002	0.04	MNX1-AS1	MNX1 antisense RNA 1 (head to head)	8383	0.17
chr1_36042987_36043882	0.04	RP4-728D4.2		104	0.95
chr17_4934347_4934505	0.04	SLC52A1	solute carrier family 52 (riboflavin transporter), member 1	4295	0.09
chr19_7985929_7986556	0.04	SNAPC2	small nuclear RNA activating complex, polypeptide 2, 45kDa	342	0.66
chr17_72744920_72745438	0.04	MIR3615	microRNA 3615	128	0.67
chr16_31880184_31880698	0.04	ZNF267	zinc finger protein 267	4638	0.26
chr12_11923358_11923509	0.04	ETV6	ets variant 6	17998	0.27
chr2_220112643_220112927	0.04	STK16	serine/threonine kinase 16	2167	0.11
chr12_40622573_40622724	0.04	LRRK2	leucine-rich repeat kinase 2	3772	0.27
chr17_41438253_41439076	0.04	ENSG00000188825	.	26121	0.1
chr15_75082239_75082553	0.04	ENSG00000264386	.	1298	0.27
chr16_8738665_8738816	0.04	METTL22	methyltransferase like 22	2415	0.28
chr9_126101731_126102049	0.04	CRB2	crumbs homolog 2 (Drosophila)	16559	0.22
chr5_142185385_142185536	0.04	ARHGAP26	Rho GTPase activating protein 26	33178	0.2
chrX_62780920_62781228	0.04	ENSG00000235437	.	123	0.98
chr6_24936325_24936476	0.04	FAM65B	family with sequence similarity 65, member B	212	0.95
chr8_131218803_131218954	0.04	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	25770	0.21
chr6_155504502_155504653	0.04	TIAM2	T-cell lymphoma invasion and metastasis 2	33194	0.19
chr2_201991504_201992128	0.04	CFLAR	CASP8 and FADD-like apoptosis regulator	2236	0.22
chr18_53256970_53257121	0.04	TCF4	transcription factor 4	0	0.99
chr2_220083227_220083846	0.03	ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6	136	0.88
chr19_42052040_42052310	0.03	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	3711	0.2
chr14_105864635_105864945	0.03	TEX22	testis expressed 22	130	0.94
chr2_238604951_238605166	0.03	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	4076	0.27
chr3_53284311_53284462	0.03	TKT	transketolase	5630	0.16
chr3_12705860_12706283	0.03	RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	346	0.88
chr1_9295235_9295615	0.03	H6PD	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	591	0.76
chr11_71639675_71639978	0.03	RNF121	ring finger protein 121	79	0.56
chr5_126147731_126147991	0.03	LMNB1	lamin B1	34980	0.19
chr1_208056352_208056503	0.03	CD34	CD34 molecule	7410	0.29
chr10_61632198_61632349	0.03	CCDC6	coiled-coil domain containing 6	34141	0.21
chr11_108108232_108108383	0.03	ENSG00000206967	.	7976	0.16
chr2_240302618_240303103	0.03	HDAC4	histone deacetylase 4	19783	0.17
chr15_68121116_68121316	0.03	SKOR1	SKI family transcriptional corepressor 1	3275	0.3
chr2_86088659_86088948	0.03	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	5974	0.2
chr16_30759296_30759478	0.03	PHKG2	phosphorylase kinase, gamma 2 (testis)	204	0.86
chr1_208041477_208041725	0.03	CD34	CD34 molecule	22236	0.23
chr14_92942291_92942442	0.03	SLC24A4	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	36658	0.18
chr11_44586532_44586926	0.03	CD82	CD82 molecule	412	0.88
chr1_40204287_40204449	0.03	PPIE	peptidylprolyl isomerase E (cyclophilin E)	186	0.92
chr1_42174997_42175148	0.03	HIVEP3	human immunodeficiency virus type I enhancer binding protein 3	8400	0.27
chr17_19015939_19016273	0.03	ENSG00000262202	.	157	0.9
chr17_18964908_18965219	0.03	ENSG00000265185	.	162	0.91
chr17_19091011_19091355	0.03	ENSG00000263934	.	146	0.9
chr17_19093552_19093880	0.03	ENSG00000264940	.	158	0.9
chr17_18967446_18967725	0.03	ENSG00000262074	.	136	0.92
chr13_96130880_96131359	0.03	CLDN10	claudin 10	45261	0.16
chr6_33168747_33168964	0.03	SLC39A7	solute carrier family 39 (zinc transporter), member 7	205	0.48
chr16_53468750_53469435	0.03	RBL2	retinoblastoma-like 2 (p130)	439	0.8
chrX_146992887_146993246	0.03	ENSG00000268066	.	269	0.62
chrX_53712878_53713294	0.03	HUWE1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	587	0.83
chr11_71751582_71752578	0.02	NUMA1	nuclear mitotic apparatus protein 1	103	0.93
chr5_77147504_77148481	0.02	TBCA	tubulin folding cofactor A	16612	0.28
chr7_142430227_142430392	0.02	PRSS1	protease, serine, 1 (trypsin 1)	27010	0.17
chr14_31028402_31029308	0.02	G2E3	G2/M-phase specific E3 ubiquitin protein ligase	339	0.9
chr19_10831379_10831550	0.02	DNM2	dynamin 2	2227	0.18
chr8_19462920_19463071	0.02	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1	2989	0.41
chr13_51490802_51491019	0.02	RNASEH2B-AS1	RNASEH2B antisense RNA 1	6062	0.21
chr1_155202832_155202983	0.02	ENSG00000216109	.	3721	0.07
chr20_52239219_52239370	0.02	ZNF217	zinc finger protein 217	13863	0.2
chr5_126323849_126324159	0.02	MARCH3	membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase	42496	0.18
chr1_8455141_8455292	0.02	RERE	arginine-glutamic acid dipeptide (RE) repeats	28510	0.15
chr5_176852709_176853043	0.02	GRK6	G protein-coupled receptor kinase 6	621	0.54
chr3_128722489_128722640	0.02	EFCC1	EF-hand and coiled-coil domain containing 1	2092	0.25
chr4_84309529_84309680	0.02	HPSE	heparanase	53298	0.12
chr1_114474532_114474797	0.02	HIPK1	homeodomain interacting protein kinase 1	1314	0.32
chr1_65533362_65534513	0.02	ENSG00000199135	.	9746	0.19
chr6_44027253_44027404	0.02	RP5-1120P11.1		15061	0.17
chr13_26796516_26796828	0.02	RNF6	ring finger protein (C3H2C3 type) 6	119	0.98
chr14_61966690_61966841	0.02	RP11-47I22.4		29081	0.17
chr7_99097527_99097880	0.02	ZNF394	zinc finger protein 394	184	0.89
chr2_69009313_69009464	0.02	ARHGAP25	Rho GTPase activating protein 25	7316	0.24
chr14_64969597_64970324	0.02	ZBTB1	zinc finger and BTB domain containing 1	483	0.49
chr21_45779191_45779342	0.02	TRPM2	transient receptor potential cation channel, subfamily M, member 2	5695	0.1
chr17_57231407_57232561	0.02	SKA2	spindle and kinetochore associated complex subunit 2	551	0.48
chr11_46143390_46143562	0.02	PHF21A	PHD finger protein 21A	491	0.82
chr3_11683730_11684257	0.02	VGLL4	vestigial like 4 (Drosophila)	1405	0.47
chrY_21728540_21728933	0.02	TXLNG2P	taxilin gamma 2, pseudogene	499	0.84
chr3_50388284_50388569	0.02	NPRL2	nitrogen permease regulator-like 2 (S. cerevisiae)	96	0.35
chr12_123921440_123921638	0.02	RILPL2	Rab interacting lysosomal protein-like 2	275	0.89
chr16_57168008_57168159	0.02	CPNE2	copine II	14972	0.14
chr5_142164826_142164977	0.02	ARHGAP26	Rho GTPase activating protein 26	12619	0.26
chr14_22950797_22950948	0.02	TRAJ55	T cell receptor alpha joining 55 (pseudogene)	186	0.79
chr4_154354394_154354673	0.02	KIAA0922	KIAA0922	32965	0.17
chr11_576246_576634	0.02	PHRF1	PHD and ring finger domains 1	46	0.93
chr8_10872806_10873547	0.02	XKR6	XK, Kell blood group complex subunit-related family, member 6	13185	0.18
chr20_44562997_44563218	0.02	PCIF1	PDX1 C-terminal inhibiting factor 1	160	0.91
chr20_48531824_48532295	0.02	SPATA2	spermatogenesis associated 2	14	0.97
chr12_89199825_89199976	0.02	ENSG00000252850	.	224484	0.02
chr7_6098442_6098863	0.02	EIF2AK1	eukaryotic translation initiation factor 2-alpha kinase 1	143	0.9
chr1_101361069_101361411	0.02	EXTL2	exostosin-like glycosyltransferase 2	314	0.5
chr2_38323518_38323669	0.02	CYP1B1-AS1	CYP1B1 antisense RNA 1	2129	0.31
chr7_132766918_132767069	0.02	CHCHD3	coiled-coil-helix-coiled-coil-helix domain containing 3	151	0.87
chr19_41082761_41083290	0.02	SHKBP1	SH3KBP1 binding protein 1	39	0.97
chr11_1595063_1595214	0.02	KRTAP5-AS1	KRTAP5-1/KRTAP5-2 antisense RNA 1	259	0.85
chr6_139309569_139309822	0.02	REPS1	RALBP1 associated Eps domain containing 1	297	0.93
chrX_2664260_2664411	0.02	XG	Xg blood group	5756	0.23
chr5_56205884_56206600	0.02	AC008937.3		299	0.48
chr1_9686401_9686552	0.02	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	25314	0.14
chr19_2888884_2889187	0.02	ZNF57	zinc finger protein 57	11861	0.1
chr10_12256838_12257395	0.01	CDC123	cell division cycle 123	15831	0.13
chr7_99647395_99647894	0.01	ZSCAN21	zinc finger and SCAN domain containing 21	227	0.84
chr4_100868040_100868504	0.01	DNAJB14	DnaJ (Hsp40) homolog, subfamily B, member 14	389	0.82
chr15_101389926_101390355	0.01	ALDH1A3	aldehyde dehydrogenase 1 family, member A3	27779	0.19
chr9_95527351_95527701	0.01	BICD2	bicaudal D homolog 2 (Drosophila)	432	0.84
chrX_154298671_154299361	0.01	MTCP1	mature T-cell proliferation 1	485	0.41
chr8_61495922_61496073	0.01	RAB2A	RAB2A, member RAS oncogene family	1285	0.53
chr11_77850351_77850689	0.01	ALG8	ALG8, alpha-1,3-glucosyltransferase	118	0.72
chr16_4524699_4524966	0.01	NMRAL1	NmrA-like family domain containing 1	64	0.56
chr4_13532847_13532998	0.01	NKX3-2	NK3 homeobox 2	13752	0.22
chr6_167411857_167412522	0.01	RP1-167A14.2		364	0.49
chr15_90920057_90920398	0.01	IQGAP1	IQ motif containing GTPase activating protein 1	11223	0.13
chr1_161102671_161103093	0.01	DEDD	death effector domain containing	404	0.63
chr11_124670044_124670876	0.01	MSANTD2	Myb/SANT-like DNA-binding domain containing 2	109	0.49
chr22_18400717_18400868	0.01	MICAL3	microtubule associated monooxygenase, calponin and LIM domain containing 3	11152	0.2
chr1_47694555_47694706	0.01	TAL1	T-cell acute lymphocytic leukemia 1	813	0.55
chr6_33172124_33172275	0.01	HSD17B8	hydroxysteroid (17-beta) dehydrogenase 8	220	0.82
chr12_6472631_6473046	0.01	SCNN1A	sodium channel, non-voltage-gated 1 alpha subunit	475	0.7
chr3_108308362_108309163	0.01	DZIP3	DAZ interacting zinc finger protein 3	140	0.82
chr17_75448601_75448829	0.01	SEPT9	septin 9	1192	0.41
chr17_35968260_35968971	0.01	SYNRG	synergin, gamma	814	0.47
chr14_90848618_90849160	0.01	ENSG00000238758	.	1347	0.42
chr3_194277134_194277288	0.01	ENSG00000252053	.	22899	0.12
chr12_7046177_7046619	0.01	C12orf57	chromosome 12 open reading frame 57	6267	0.06
chr11_46581907_46582403	0.01	AMBRA1	autophagy/beclin-1 regulator 1	30759	0.15
chr8_82059369_82059520	0.01	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	35141	0.21
chr17_37844122_37844360	0.01	PGAP3	post-GPI attachment to proteins 3	69	0.49
chr17_41323238_41323851	0.01	NBR1	neighbor of BRCA1 gene 1	284	0.87
chrX_152200749_152200932	0.01	PNMA3	paraneoplastic Ma antigen 3	23926	0.12
chr14_68086133_68086429	0.01	ARG2	arginase 2	234	0.87
chr19_54714818_54714969	0.01	RPS9	ribosomal protein S9	9865	0.07
chr1_202976092_202976359	0.01	TMEM183A	transmembrane protein 183A	289	0.86
chr16_85608858_85609009	0.01	GSE1	Gse1 coiled-coil protein	36082	0.17
chr19_11200787_11200965	0.01	LDLR	low density lipoprotein receptor	399	0.82
chr18_32956679_32957498	0.01	ZNF396	zinc finger protein 396	186	0.96
chr22_22337183_22337444	0.01	TOP3B	topoisomerase (DNA) III beta	100	0.94
chr8_100025267_100025604	0.01	VPS13B	vacuolar protein sorting 13 homolog B (yeast)	59	0.97
chr15_89949662_89949989	0.01	ENSG00000207819	.	38577	0.14
chr2_27805637_27805914	0.01	ZNF512	zinc finger protein 512	122	0.9
chr3_190331805_190331956	0.01	IL1RAP	interleukin 1 receptor accessory protein	1217	0.57
chr6_111198520_111198699	0.01	AMD1	adenosylmethionine decarboxylase 1	1831	0.3
chr2_74682121_74682812	0.01	INO80B	INO80 complex subunit B	223	0.81
chr10_65280480_65280949	0.01	REEP3	receptor accessory protein 3	409	0.89
chr4_1161098_1161472	0.01	RP11-20I20.4		281	0.86
chr5_154140674_154140825	0.01	LARP1	La ribonucleoprotein domain family, member 1	4015	0.22
chrX_128978019_128978341	0.01	ZDHHC9	zinc finger, DHHC-type containing 9	295	0.91
chr12_90103618_90104485	0.01	ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	974	0.58
chr20_23330489_23330738	0.01	NXT1	NTF2-like export factor 1	760	0.44
chr17_80255580_80256204	0.01	CD7	CD7 molecule	19536	0.1
chr8_97127078_97127229	0.01	GDF6	growth differentiation factor 6	45867	0.17
chrX_39949292_39950247	0.01	BCOR	BCL6 corepressor	6887	0.33
chr2_234263629_234264304	0.01	DGKD	diacylglycerol kinase, delta 130kDa	812	0.51
chr13_52586601_52587118	0.01	ALG11	ALG11, alpha-1,2-mannosyltransferase	309	0.84
chr12_113623531_113623954	0.01	RITA1	RBPJ interacting and tubulin associated 1	395	0.48
chr2_67624524_67625302	0.01	ETAA1	Ewing tumor-associated antigen 1	462	0.91
chr17_66243472_66244013	0.01	AMZ2	archaelysin family metallopeptidase 2	27	0.83
chr2_26367902_26368120	0.01	GAREML	GRB2 associated, regulator of MAPK1-like	27949	0.17
chr5_114632718_114632869	0.01	CCDC112	coiled-coil domain containing 112	265	0.92
chr4_2802836_2803519	0.01	SH3BP2	SH3-domain binding protein 2	2452	0.3
chr19_49977180_49977368	0.01	FLT3LG	fms-related tyrosine kinase 3 ligand	211	0.79
chr14_58893255_58894222	0.01	TIMM9	translocase of inner mitochondrial membrane 9 homolog (yeast)	94	0.8
chr16_1772321_1772575	0.01	LA16c-329F2.1		8239	0.08
chr7_10978872_10979727	0.01	NDUFA4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa	584	0.8
chr12_29301686_29302400	0.01	FAR2	fatty acyl CoA reductase 2	7	0.99
chr5_43121819_43122643	0.01	ZNF131	zinc finger protein 131	90	0.97
chr5_132299396_132299679	0.01	AFF4	AF4/FMR2 family, member 4	211	0.92
chr19_54975667_54976253	0.01	LENG9	leukocyte receptor cluster (LRC) member 9	1066	0.31
chr13_50701261_50702144	0.01	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	45395	0.14
chr2_42588838_42589158	0.01	COX7A2L	cytochrome c oxidase subunit VIIa polypeptide 2 like	642	0.78
chr12_132293323_132293474	0.01	ENSG00000200483	.	6515	0.17
chr4_41992555_41992786	0.01	SLC30A9	solute carrier family 30 (zinc transporter), member 9	181	0.96
chr4_103265993_103266510	0.01	SLC39A8	solute carrier family 39 (zinc transporter), member 8	45	0.98

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.0	GO:0097501	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0008537	proteasome activator complex(GO:0008537)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.0	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.0	GO:0015562	efflux transmembrane transporter activity(GO:0015562)