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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SRF

Z-value: 0.96

Motif logo

Transcription factors associated with SRF

Gene Symbol	Gene ID	Gene Info
SRF Ensembl NCBI GeneCards UniProt	ENSG00000112658.6	SRF

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SRF	chr6_43143818_43143969	3765	0.148525	0.64	6.2e-02	Click!
SRF	chr6_43141770_43142073	1793	0.242388	0.50	1.7e-01	Click!
SRF	chr6_43140857_43141008	804	0.508783	0.41	2.8e-01	Click!
SRF	chr6_43142093_43142405	2121	0.210632	0.33	3.9e-01	Click!
SRF	chr6_43142593_43142764	2550	0.184052	0.25	5.1e-01	Click!

Activity of the SRF motif across conditions

Conditions sorted by the z-value of the SRF motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_103048383_103048621	0.58	PLP1	proteolipid protein 1	16724	0.13
chr7_28727324_28727475	0.54	CREB5	cAMP responsive element binding protein 5	1801	0.52
chr5_92918344_92919004	0.52	NR2F1	nuclear receptor subfamily 2, group F, member 1	369	0.84
chr2_118737624_118738057	0.45	AC009303.1		15133	0.14
chr3_25470006_25470271	0.45	RARB	retinoic acid receptor, beta	336	0.93
chr1_12588381_12588669	0.44	ENSG00000239149	.	21225	0.17
chr5_2750019_2750705	0.43	IRX2	iroquois homeobox 2	1407	0.43
chr11_6340282_6340518	0.43	PRKCDBP	protein kinase C, delta binding protein	1362	0.38
chr15_26020644_26020846	0.42	ENSG00000222123	.	37090	0.15
chr3_64674409_64674678	0.41	ADAMTS9	ADAM metallopeptidase with thrombospondin type 1 motif, 9	867	0.65
chr21_36255325_36255652	0.41	RUNX1	runt-related transcription factor 1	3992	0.36
chr6_108434801_108435121	0.40	OSTM1	osteopetrosis associated transmembrane protein 1	39020	0.14
chr3_157250255_157250502	0.39	VEPH1	ventricular zone expressed PH domain-containing 1	1017	0.61
chr15_39871853_39872515	0.38	THBS1	thrombospondin 1	1096	0.52
chr3_25193145_25193356	0.38	RARB	retinoic acid receptor, beta	22573	0.26
chr16_15952010_15952161	0.37	MYH11	myosin, heavy chain 11, smooth muscle	1195	0.43
chr6_2376939_2377282	0.37	ENSG00000266252	.	32759	0.23
chr7_139542200_139542351	0.36	TBXAS1	thromboxane A synthase 1 (platelet)	13165	0.26
chr8_86350363_86351282	0.35	CA3	carbonic anhydrase III, muscle specific	234	0.93
chr4_170188672_170188986	0.35	SH3RF1	SH3 domain containing ring finger 1	2279	0.41
chr15_51401233_51401466	0.33	TNFAIP8L3	tumor necrosis factor, alpha-induced protein 8-like 3	3876	0.27
chr1_154163082_154163233	0.32	TPM3	tropomyosin 3	1377	0.24
chr7_34027132_34027307	0.32	BMPER	BMP binding endothelial regulator	82074	0.11
chr12_121086851_121087153	0.32	CABP1	calcium binding protein 1	886	0.46
chr1_156098945_156099118	0.32	LMNA	lamin A/C	2437	0.17
chr12_110547123_110547283	0.31	IFT81	intraflagellar transport 81 homolog (Chlamydomonas)	14937	0.2
chr7_68895099_68895250	0.31	ENSG00000252423	.	28885	0.22
chr3_99679660_99679890	0.31	ENSG00000264897	.	3467	0.34
chr2_12927970_12928158	0.31	ENSG00000264370	.	50571	0.17
chr8_89338891_89339093	0.29	RP11-586K2.1		73	0.93
chr1_223889194_223889423	0.29	CAPN2	calpain 2, (m/II) large subunit	13	0.98
chr15_35598885_35599113	0.29	ENSG00000265102	.	65566	0.14
chr8_26123485_26124097	0.29	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	25216	0.23
chr15_68871678_68872325	0.29	CORO2B	coronin, actin binding protein, 2B	428	0.9
chr10_29923748_29924013	0.28	SVIL	supervillin	21	0.98
chr14_56792096_56792462	0.28	TMEM260	transmembrane protein 260	162793	0.04
chr4_89977525_89978081	0.28	FAM13A	family with sequence similarity 13, member A	508	0.85
chr1_180126514_180126782	0.28	QSOX1	quiescin Q6 sulfhydryl oxidase 1	2616	0.34
chr1_157964321_157964712	0.28	KIRREL	kin of IRRE like (Drosophila)	1081	0.56
chr8_119961799_119961950	0.27	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	2565	0.34
chr5_139145492_139145717	0.27	PSD2	pleckstrin and Sec7 domain containing 2	29802	0.16
chrX_100334578_100334939	0.27	TMEM35	transmembrane protein 35	1049	0.47
chr6_78172796_78173983	0.27	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	101	0.99
chr5_142875468_142875722	0.26	ENSG00000253023	.	46557	0.16
chr12_54414044_54414195	0.26	HOXC4	homeobox C4	3404	0.08
chr10_17256481_17257128	0.26	VIM-AS1	VIM antisense RNA 1	12093	0.15
chr5_120534956_120535178	0.26	ENSG00000222609	.	488532	0.01
chr12_115113843_115113994	0.26	TBX3	T-box 3	7477	0.23
chr2_208578578_208578729	0.25	CCNYL1	cyclin Y-like 1	2178	0.25
chr12_112534683_112534834	0.25	NAA25	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	11789	0.13
chrX_80514661_80514812	0.25	ENSG00000264374	.	18417	0.23
chr12_109123891_109124402	0.25	CORO1C	coronin, actin binding protein, 1C	181	0.94
chr2_161236822_161236973	0.25	ENSG00000252465	.	16582	0.2
chr14_34161873_34162024	0.25	NPAS3	neuronal PAS domain protein 3	42499	0.22
chrX_153601896_153602918	0.25	FLNA	filamin A, alpha	587	0.54
chr15_63179528_63179679	0.24	RP11-1069G10.1		3370	0.3
chr10_33621519_33621932	0.24	NRP1	neuropilin 1	1585	0.49
chr5_76786577_76786860	0.24	WDR41	WD repeat domain 41	392	0.91
chr18_57488899_57489050	0.24	ENSG00000221471	.	72065	0.1
chr21_28215844_28216573	0.24	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	112	0.98
chr3_160191571_160191722	0.24	ENSG00000238427	.	1442	0.35
chr1_95332163_95332314	0.24	SLC44A3	solute carrier family 44, member 3	649	0.72
chr16_84328151_84329018	0.24	WFDC1	WAP four-disulfide core domain 1	132	0.94
chr8_97398942_97399239	0.24	ENSG00000202095	.	44298	0.15
chr9_97818122_97818533	0.24	ENSG00000207563	.	29163	0.12
chr6_17932450_17932601	0.23	KIF13A	kinesin family member 13A	55169	0.15
chr15_70995926_70996077	0.23	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	387	0.91
chr4_56264706_56264857	0.23	TMEM165	transmembrane protein 165	2651	0.21
chr8_62625183_62625719	0.23	ASPH	aspartate beta-hydroxylase	1633	0.37
chr12_15930396_15930547	0.23	EPS8	epidermal growth factor receptor pathway substrate 8	3190	0.35
chr9_122130687_122130838	0.23	BRINP1	bone morphogenetic protein/retinoic acid inducible neural-specific 1	941	0.74
chr1_114761855_114762022	0.23	SYT6	synaptotagmin VI	65397	0.13
chr15_40632274_40632449	0.22	C15orf52	chromosome 15 open reading frame 52	118	0.91
chr5_89351556_89351717	0.22	ENSG00000264342	.	39099	0.23
chr2_66664825_66665240	0.22	MEIS1	Meis homeobox 1	93	0.96
chr2_241520309_241520460	0.22	RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1	5465	0.12
chr3_93743277_93743462	0.22	STX19	syntaxin 19	4085	0.18
chr5_173390424_173390761	0.22	C5orf47	chromosome 5 open reading frame 47	25570	0.2
chr11_118435857_118436109	0.22	IFT46	intraflagellar transport 46 homolog (Chlamydomonas)	378	0.76
chr3_149902419_149902570	0.22	RP11-167H9.4		86675	0.09
chr12_104990144_104990321	0.21	ENSG00000264295	.	4821	0.26
chr8_9953745_9953924	0.21	MSRA	methionine sulfoxide reductase A	597	0.76
chr4_113739998_113740296	0.21	ANK2	ankyrin 2, neuronal	882	0.65
chr3_185531595_185531973	0.21	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2	7065	0.24
chr1_216705335_216705486	0.21	USH2A	Usher syndrome 2A (autosomal recessive, mild)	108672	0.08
chr2_26258800_26259062	0.21	RAB10	RAB10, member RAS oncogene family	1952	0.29
chr12_54426653_54426823	0.21	HOXC5	homeobox C5	101	0.88
chr6_43141770_43142073	0.21	SRF	serum response factor (c-fos serum response element-binding transcription factor)	1793	0.24
chr18_66106611_66106762	0.20	TMX3	thioredoxin-related transmembrane protein 3	275608	0.02
chr3_48646099_48647042	0.20	UQCRC1	ubiquinol-cytochrome c reductase core protein I	900	0.38
chr6_17283021_17283300	0.20	RBM24	RNA binding motif protein 24	228	0.96
chr20_10651490_10651885	0.20	RP11-103J8.1		1889	0.38
chr7_55546043_55546306	0.20	VOPP1	vesicular, overexpressed in cancer, prosurvival protein 1	37596	0.19
chr16_54465247_54465407	0.20	ENSG00000264079	.	117981	0.06
chr1_178837029_178837180	0.20	ANGPTL1	angiopoietin-like 1	1309	0.49
chr3_159451123_159451337	0.20	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	30272	0.17
chr8_48392520_48392671	0.20	SPIDR	scaffolding protein involved in DNA repair	39632	0.18
chr6_105936815_105937042	0.20	PREP	prolyl endopeptidase	85969	0.1
chr15_35087756_35087962	0.20	ACTC1	actin, alpha, cardiac muscle 1	481	0.83
chr8_67015907_67016058	0.19	TRIM55	tripartite motif containing 55	23149	0.22
chr21_35925267_35925598	0.19	RCAN1	regulator of calcineurin 1	7045	0.23
chr17_76880061_76880570	0.19	TIMP2	TIMP metallopeptidase inhibitor 2	10083	0.14
chr17_36621594_36621757	0.19	ARHGAP23	Rho GTPase activating protein 23	6505	0.17
chr19_13135028_13135217	0.19	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	272	0.84
chr14_23538007_23538158	0.19	ACIN1	apoptotic chromatin condensation inducer 1	2665	0.13
chr5_14171520_14171879	0.19	TRIO	trio Rho guanine nucleotide exchange factor	12208	0.31
chr4_81118792_81119547	0.19	PRDM8	PR domain containing 8	511	0.82
chr6_5208630_5208872	0.19	ENSG00000264541	.	16279	0.2
chr2_64539316_64539525	0.18	ENSG00000264297	.	28473	0.21
chr5_173207490_173207641	0.18	ENSG00000263401	.	50484	0.16
chr21_36254420_36254945	0.18	RUNX1	runt-related transcription factor 1	4798	0.34
chr2_69405192_69405451	0.18	ENSG00000251850	.	3814	0.24
chr18_56665001_56665175	0.18	ENSG00000251870	.	71560	0.1
chr6_33180748_33181418	0.18	RING1	ring finger protein 1	4811	0.08
chr11_117069900_117070051	0.18	TAGLN	transgelin	62	0.96
chr9_128235766_128235975	0.18	MAPKAP1	mitogen-activated protein kinase associated protein 1	10910	0.23
chr5_127447715_127447866	0.18	SLC12A2	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	28250	0.26
chr11_64389104_64389255	0.18	NRXN2	neurexin 2	20979	0.13
chr4_185744284_185744435	0.18	ACSL1	acyl-CoA synthetase long-chain family member 1	2829	0.25
chr11_110967368_110967519	0.18	ENSG00000200168	.	56511	0.15
chr1_98569393_98569544	0.18	ENSG00000225206	.	57741	0.17
chr9_14320711_14320862	0.18	NFIB	nuclear factor I/B	1551	0.46
chr18_65661971_65662168	0.18	DSEL	dermatan sulfate epimerase-like	477852	0.01
chrX_152761685_152761943	0.18	HAUS7	HAUS augmin-like complex, subunit 7	836	0.41
chr4_55100810_55101099	0.17	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	4465	0.31
chr10_97501950_97502206	0.17	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	13331	0.21
chr6_152701268_152701555	0.17	SYNE1-AS1	SYNE1 antisense RNA 1	270	0.91
chr4_24796744_24797030	0.17	SOD3	superoxide dismutase 3, extracellular	198	0.97
chr20_34025363_34025770	0.17	GDF5	growth differentiation factor 5	457	0.71
chr8_99007536_99007844	0.17	MATN2	matrilin 2	21082	0.15
chr15_96869088_96869239	0.17	NR2F2	nuclear receptor subfamily 2, group F, member 2	4	0.96
chr17_58821066_58821723	0.17	ENSG00000252534	.	5013	0.22
chr4_23892235_23892469	0.17	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	652	0.82
chr8_29107320_29107471	0.17	KIF13B	kinesin family member 13B	13195	0.17
chr6_2468845_2468996	0.17	ENSG00000266252	.	59051	0.15
chr15_68573463_68573639	0.17	FEM1B	fem-1 homolog b (C. elegans)	1254	0.47
chr16_87481635_87481786	0.17	ZCCHC14	zinc finger, CCHC domain containing 14	14970	0.16
chr14_75688794_75688945	0.17	ENSG00000252013	.	19997	0.14
chr6_3749707_3750198	0.17	RP11-420L9.5		1393	0.41
chr18_395366_395517	0.17	RP11-720L2.2		28975	0.2
chr2_109257559_109258085	0.17	LIMS1	LIM and senescent cell antigen-like domains 1	13446	0.22
chr17_56031961_56032485	0.17	CUEDC1	CUE domain containing 1	395	0.83
chr5_73109422_73109633	0.17	ARHGEF28	Rho guanine nucleotide exchange factor (GEF) 28	184	0.95
chr15_63305654_63305860	0.16	TPM1	tropomyosin 1 (alpha)	29074	0.16
chr5_150284813_150285011	0.16	ZNF300	zinc finger protein 300	367	0.87
chrX_45613808_45613959	0.16	ENSG00000207725	.	7353	0.25
chr4_95332017_95332168	0.16	PDLIM5	PDZ and LIM domain 5	40945	0.2
chr11_34675128_34675279	0.16	EHF	ets homologous factor	11029	0.28
chr1_16212355_16212620	0.16	SPEN	spen family transcriptional repressor	9416	0.15
chr6_166532528_166532679	0.16	ENSG00000231297	.	19262	0.22
chr22_27105780_27105987	0.16	CRYBA4	crystallin, beta A4	87955	0.08
chr16_3309520_3309673	0.16	MEFV	Mediterranean fever	2969	0.14
chr3_72287415_72287566	0.16	ENSG00000212070	.	24089	0.27
chr2_234151079_234151230	0.16	ATG16L1	autophagy related 16-like 1 (S. cerevisiae)	9063	0.15
chr22_39260401_39260552	0.16	CBX6	chromobox homolog 6	7745	0.14
chr6_16849709_16849927	0.16	RP1-151F17.1		87675	0.09
chr18_37379955_37380106	0.16	ENSG00000212354	.	121444	0.06
chr2_33391334_33391485	0.16	LTBP1	latent transforming growth factor beta binding protein 1	31685	0.23
chrX_34673939_34674563	0.16	TMEM47	transmembrane protein 47	1154	0.68
chr1_68215659_68215876	0.16	ENSG00000238778	.	22569	0.2
chr1_29066466_29066617	0.16	YTHDF2	YTH domain family, member 2	3064	0.23
chr21_34677268_34677419	0.16	IFNAR1	interferon (alpha, beta and omega) receptor 1	19391	0.14
chr2_99767240_99767391	0.16	TSGA10	testis specific, 10	4065	0.14
chr4_186425617_186425867	0.16	PDLIM3	PDZ and LIM domain 3	30914	0.12
chr2_20001539_20001690	0.16	TTC32	tetratricopeptide repeat domain 32	99788	0.08
chr2_102321542_102321693	0.16	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	6625	0.32
chr8_91996797_91997429	0.16	C8orf88	chromosome 8 open reading frame 88	372	0.85
chr14_55239224_55239463	0.15	SAMD4A	sterile alpha motif domain containing 4A	17792	0.24
chr8_57595049_57595246	0.15	RP11-17A4.2		193490	0.03
chr16_1664599_1665551	0.15	CRAMP1L	Crm, cramped-like (Drosophila)	434	0.69
chr20_58516772_58516923	0.15	FAM217B	family with sequence similarity 217, member B	332	0.82
chr5_115313493_115313761	0.15	AQPEP	Aminopeptidase Q	15436	0.17
chr2_199237110_199237329	0.15	ENSG00000252511	.	194234	0.03
chr21_15921425_15921576	0.15	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	2836	0.33
chr6_138170630_138170781	0.15	RP11-356I2.4		8480	0.22
chr3_150089259_150089633	0.15	TSC22D2	TSC22 domain family, member 2	36676	0.21
chr6_164530063_164530741	0.15	ENSG00000266128	.	268809	0.02
chr5_146933859_146934303	0.15	DPYSL3	dihydropyrimidinase-like 3	44462	0.19
chr1_23066485_23066803	0.15	ENSG00000216157	.	8760	0.17
chr11_63438034_63439177	0.15	ATL3	atlastin GTPase 3	479	0.76
chr2_160418896_160419047	0.15	ENSG00000207117	.	26114	0.19
chr1_63590436_63590751	0.15	ENSG00000252259	.	61528	0.14
chr4_79473579_79473973	0.15	ANXA3	annexin A3	655	0.79
chr2_175203738_175203889	0.15	AC018470.1	Uncharacterized protein FLJ46347	1662	0.32
chr10_104817675_104817826	0.15	NT5C2	5'-nucleotidase, cytosolic II	36375	0.18
chr8_38264174_38264701	0.15	RP11-350N15.6		1823	0.22
chrX_47142357_47142518	0.15	ENSG00000266158	.	1975	0.25
chr8_122419386_122419537	0.14	ENSG00000263525	.	135774	0.05
chr7_5710455_5710606	0.14	RNF216-IT1	RNF216 intronic transcript 1 (non-protein coding)	9562	0.21
chr5_53358972_53359145	0.14	ENSG00000265421	.	12355	0.22
chr11_59021844_59021995	0.14	ENSG00000263944	.	36887	0.12
chr5_157911190_157911341	0.14	CTD-2363C16.1		498749	0.0
chr14_21564786_21565064	0.14	ZNF219	zinc finger protein 219	1874	0.17
chr2_85504683_85504834	0.14	ENSG00000221579	.	21399	0.12
chr12_112560647_112560960	0.14	TRAFD1	TRAF-type zinc finger domain containing 1	2502	0.22
chrX_10851859_10852068	0.14	MID1	midline 1 (Opitz/BBB syndrome)	190	0.97
chr9_99249166_99249317	0.14	HABP4	hyaluronan binding protein 4	36754	0.17
chr20_61817533_61817684	0.14	ENSG00000207598	.	7756	0.14
chr1_225635412_225635563	0.14	RP11-496N12.6		17498	0.17
chr19_11650748_11650916	0.14	CNN1	calponin 1, basic, smooth muscle	123	0.92

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.1	0.2	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.4	GO:0014866	skeletal myofibril assembly(GO:0014866)
0.1	0.2	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.1	0.2	GO:0031223	auditory behavior(GO:0031223)
0.1	0.2	GO:0072081	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.1	0.2	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1	0.2	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.2	GO:0060347	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.3	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.3	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.5	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	0.1	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.0	0.1	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.1	GO:0032291	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0031033	myosin filament organization(GO:0031033)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.2	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0090009	primitive streak formation(GO:0090009)
0.0	0.1	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:2001280	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.2	GO:0036296	response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0	0.2	GO:0010830	regulation of myotube differentiation(GO:0010830)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.2	GO:0006555	methionine metabolic process(GO:0006555)
0.0	0.0	GO:0032616	interleukin-13 production(GO:0032616)
0.0	0.2	GO:0019430	removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0	0.0	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.0	GO:0001714	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.4	GO:0006730	one-carbon metabolic process(GO:0006730)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.0	GO:0003148	outflow tract septum morphogenesis(GO:0003148)
0.0	0.1	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.0	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.1	GO:0009886	post-embryonic morphogenesis(GO:0009886)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0031114	negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0002347	response to tumor cell(GO:0002347)
0.0	0.0	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.0	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.0	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.0	GO:0060751	branch elongation involved in mammary gland duct branching(GO:0060751)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.2	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.1	GO:0033085	negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399)
0.0	0.0	GO:0048569	post-embryonic organ development(GO:0048569)
0.0	0.5	GO:0034339	obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor(GO:0034339)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.2	GO:0005859	muscle myosin complex(GO:0005859)
0.0	0.1	GO:0030992	intraciliary transport particle(GO:0030990) intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0016151	nickel cation binding(GO:0016151)
0.1	0.7	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.1	0.5	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.1	0.2	GO:0070052	collagen V binding(GO:0070052)
0.1	0.2	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.2	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.2	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.3	GO:0051378	serotonin binding(GO:0051378)
0.0	0.2	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.2	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0001077	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.1	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.0	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0016679	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.6	GO:0051015	actin filament binding(GO:0051015)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.2	GO:0017022	myosin binding(GO:0017022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.5	PID HNF3A PATHWAY	FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME SIGNALING BY ILS	Genes involved in Signaling by Interleukins
0.4	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.3	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway