Project
ENCODE: H3K4me3 ChIP-Seq of primary human cells
Navigation
Downloads
Logo

Results for SRF

Z-value: 0.96

Motif logo

logo of

Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
SRF
ENSG00000112658.6 serum response factor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr6_43143818_43143969SRF37650.1485250.646.2e-02Click!
chr6_43141770_43142073SRF17930.2423880.501.7e-01Click!
chr6_43140857_43141008SRF8040.5087830.412.8e-01Click!
chr6_43142093_43142405SRF21210.2106320.333.9e-01Click!
chr6_43142593_43142764SRF25500.1840520.255.1e-01Click!

Activity of the SRF motif across conditions

Conditions sorted by the z-value of the SRF motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chrX_103048383_103048621 0.58 PLP1
 proteolipid protein 1
 16724
 0.13
chr7_28727324_28727475 0.54 CREB5
 cAMP responsive element binding protein 5
 1801
 0.52
chr5_92918344_92919004 0.52 NR2F1
 nuclear receptor subfamily 2, group F, member 1
 369
 0.84
chr2_118737624_118738057 0.45 AC009303.1
15133
 0.14
chr3_25470006_25470271 0.45 RARB
 retinoic acid receptor, beta
 336
 0.93
chr1_12588381_12588669 0.44 ENSG00000239149
 .
 21225
 0.17
chr5_2750019_2750705 0.43 IRX2
 iroquois homeobox 2
 1407
 0.43
chr11_6340282_6340518 0.43 PRKCDBP
 protein kinase C, delta binding protein
 1362
 0.38
chr15_26020644_26020846 0.42 ENSG00000222123
 .
 37090
 0.15
chr3_64674409_64674678 0.41 ADAMTS9
 ADAM metallopeptidase with thrombospondin type 1 motif, 9
 867
 0.65
chr21_36255325_36255652 0.41 RUNX1
 runt-related transcription factor 1
 3992
 0.36
chr6_108434801_108435121 0.40 OSTM1
 osteopetrosis associated transmembrane protein 1
 39020
 0.14
chr3_157250255_157250502 0.39 VEPH1
 ventricular zone expressed PH domain-containing 1
 1017
 0.61
chr15_39871853_39872515 0.38 THBS1
 thrombospondin 1
 1096
 0.52
chr3_25193145_25193356 0.38 RARB
 retinoic acid receptor, beta
 22573
 0.26
chr16_15952010_15952161 0.37 MYH11
 myosin, heavy chain 11, smooth muscle
 1195
 0.43
chr6_2376939_2377282 0.37 ENSG00000266252
 .
 32759
 0.23
chr7_139542200_139542351 0.36 TBXAS1
 thromboxane A synthase 1 (platelet)
 13165
 0.26
chr8_86350363_86351282 0.35 CA3
 carbonic anhydrase III, muscle specific
 234
 0.93
chr4_170188672_170188986 0.35 SH3RF1
 SH3 domain containing ring finger 1
 2279
 0.41
chr15_51401233_51401466 0.33 TNFAIP8L3
 tumor necrosis factor, alpha-induced protein 8-like 3
 3876
 0.27
chr1_154163082_154163233 0.32 TPM3
 tropomyosin 3
 1377
 0.24
chr7_34027132_34027307 0.32 BMPER
 BMP binding endothelial regulator
 82074
 0.11
chr12_121086851_121087153 0.32 CABP1
 calcium binding protein 1
 886
 0.46
chr1_156098945_156099118 0.32 LMNA
 lamin A/C
 2437
 0.17
chr12_110547123_110547283 0.31 IFT81
 intraflagellar transport 81 homolog (Chlamydomonas)
 14937
 0.2
chr7_68895099_68895250 0.31 ENSG00000252423
 .
 28885
 0.22
chr3_99679660_99679890 0.31 ENSG00000264897
 .
 3467
 0.34
chr2_12927970_12928158 0.31 ENSG00000264370
 .
 50571
 0.17
chr8_89338891_89339093 0.29 RP11-586K2.1
73
 0.93
chr1_223889194_223889423 0.29 CAPN2
 calpain 2, (m/II) large subunit
 13
 0.98
chr15_35598885_35599113 0.29 ENSG00000265102
 .
 65566
 0.14
chr8_26123485_26124097 0.29 PPP2R2A
 protein phosphatase 2, regulatory subunit B, alpha
 25216
 0.23
chr15_68871678_68872325 0.29 CORO2B
 coronin, actin binding protein, 2B
 428
 0.9
chr10_29923748_29924013 0.28 SVIL
 supervillin
 21
 0.98
chr14_56792096_56792462 0.28 TMEM260
 transmembrane protein 260
 162793
 0.04
chr4_89977525_89978081 0.28 FAM13A
 family with sequence similarity 13, member A
 508
 0.85
chr1_180126514_180126782 0.28 QSOX1
 quiescin Q6 sulfhydryl oxidase 1
 2616
 0.34
chr1_157964321_157964712 0.28 KIRREL
 kin of IRRE like (Drosophila)
 1081
 0.56
chr8_119961799_119961950 0.27 TNFRSF11B
 tumor necrosis factor receptor superfamily, member 11b
 2565
 0.34
chr5_139145492_139145717 0.27 PSD2
 pleckstrin and Sec7 domain containing 2
 29802
 0.16
chrX_100334578_100334939 0.27 TMEM35
 transmembrane protein 35
 1049
 0.47
chr6_78172796_78173983 0.27 HTR1B
 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
 101
 0.99
chr5_142875468_142875722 0.26 ENSG00000253023
 .
 46557
 0.16
chr12_54414044_54414195 0.26 HOXC4
 homeobox C4
 3404
 0.08
chr10_17256481_17257128 0.26 VIM-AS1
 VIM antisense RNA 1
 12093
 0.15
chr5_120534956_120535178 0.26 ENSG00000222609
 .
 488532
 0.01
chr12_115113843_115113994 0.26 TBX3
 T-box 3
 7477
 0.23
chr2_208578578_208578729 0.25 CCNYL1
 cyclin Y-like 1
 2178
 0.25
chr12_112534683_112534834 0.25 NAA25
 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
 11789
 0.13
chrX_80514661_80514812 0.25 ENSG00000264374
 .
 18417
 0.23
chr12_109123891_109124402 0.25 CORO1C
 coronin, actin binding protein, 1C
 181
 0.94
chr2_161236822_161236973 0.25 ENSG00000252465
 .
 16582
 0.2
chr14_34161873_34162024 0.25 NPAS3
 neuronal PAS domain protein 3
 42499
 0.22
chrX_153601896_153602918 0.25 FLNA
 filamin A, alpha
 587
 0.54
chr15_63179528_63179679 0.24 RP11-1069G10.1
3370
 0.3
chr10_33621519_33621932 0.24 NRP1
 neuropilin 1
 1585
 0.49
chr5_76786577_76786860 0.24 WDR41
 WD repeat domain 41
 392
 0.91
chr18_57488899_57489050 0.24 ENSG00000221471
 .
 72065
 0.1
chr21_28215844_28216573 0.24 ADAMTS1
 ADAM metallopeptidase with thrombospondin type 1 motif, 1
 112
 0.98
chr3_160191571_160191722 0.24 ENSG00000238427
 .
 1442
 0.35
chr1_95332163_95332314 0.24 SLC44A3
 solute carrier family 44, member 3
 649
 0.72
chr16_84328151_84329018 0.24 WFDC1
 WAP four-disulfide core domain 1
 132
 0.94
chr8_97398942_97399239 0.24 ENSG00000202095
 .
 44298
 0.15
chr9_97818122_97818533 0.24 ENSG00000207563
 .
 29163
 0.12
chr6_17932450_17932601 0.23 KIF13A
 kinesin family member 13A
 55169
 0.15
chr15_70995926_70996077 0.23 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 387
 0.91
chr4_56264706_56264857 0.23 TMEM165
 transmembrane protein 165
 2651
 0.21
chr8_62625183_62625719 0.23 ASPH
 aspartate beta-hydroxylase
 1633
 0.37
chr12_15930396_15930547 0.23 EPS8
 epidermal growth factor receptor pathway substrate 8
 3190
 0.35
chr9_122130687_122130838 0.23 BRINP1
 bone morphogenetic protein/retinoic acid inducible neural-specific 1
 941
 0.74
chr1_114761855_114762022 0.23 SYT6
 synaptotagmin VI
 65397
 0.13
chr15_40632274_40632449 0.22 C15orf52
 chromosome 15 open reading frame 52
 118
 0.91
chr5_89351556_89351717 0.22 ENSG00000264342
 .
 39099
 0.23
chr2_66664825_66665240 0.22 MEIS1
 Meis homeobox 1
 93
 0.96
chr2_241520309_241520460 0.22 RNPEPL1
 arginyl aminopeptidase (aminopeptidase B)-like 1
 5465
 0.12
chr3_93743277_93743462 0.22 STX19
 syntaxin 19
 4085
 0.18
chr5_173390424_173390761 0.22 C5orf47
 chromosome 5 open reading frame 47
 25570
 0.2
chr11_118435857_118436109 0.22 IFT46
 intraflagellar transport 46 homolog (Chlamydomonas)
 378
 0.76
chr3_149902419_149902570 0.22 RP11-167H9.4
86675
 0.09
chr12_104990144_104990321 0.21 ENSG00000264295
 .
 4821
 0.26
chr8_9953745_9953924 0.21 MSRA
 methionine sulfoxide reductase A
 597
 0.76
chr4_113739998_113740296 0.21 ANK2
 ankyrin 2, neuronal
 882
 0.65
chr3_185531595_185531973 0.21 IGF2BP2
 insulin-like growth factor 2 mRNA binding protein 2
 7065
 0.24
chr1_216705335_216705486 0.21 USH2A
 Usher syndrome 2A (autosomal recessive, mild)
 108672
 0.08
chr2_26258800_26259062 0.21 RAB10
 RAB10, member RAS oncogene family
 1952
 0.29
chr12_54426653_54426823 0.21 HOXC5
 homeobox C5
 101
 0.88
chr6_43141770_43142073 0.21 SRF
 serum response factor (c-fos serum response element-binding transcription factor)
 1793
 0.24
chr18_66106611_66106762 0.20 TMX3
 thioredoxin-related transmembrane protein 3
 275608
 0.02
chr3_48646099_48647042 0.20 UQCRC1
 ubiquinol-cytochrome c reductase core protein I
 900
 0.38
chr6_17283021_17283300 0.20 RBM24
 RNA binding motif protein 24
 228
 0.96
chr20_10651490_10651885 0.20 RP11-103J8.1
1889
 0.38
chr7_55546043_55546306 0.20 VOPP1
 vesicular, overexpressed in cancer, prosurvival protein 1
 37596
 0.19
chr16_54465247_54465407 0.20 ENSG00000264079
 .
 117981
 0.06
chr1_178837029_178837180 0.20 ANGPTL1
 angiopoietin-like 1
 1309
 0.49
chr3_159451123_159451337 0.20 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 30272
 0.17
chr8_48392520_48392671 0.20 SPIDR
 scaffolding protein involved in DNA repair
 39632
 0.18
chr6_105936815_105937042 0.20 PREP
 prolyl endopeptidase
 85969
 0.1
chr15_35087756_35087962 0.20 ACTC1
 actin, alpha, cardiac muscle 1
 481
 0.83
chr8_67015907_67016058 0.19 TRIM55
 tripartite motif containing 55
 23149
 0.22
chr21_35925267_35925598 0.19 RCAN1
 regulator of calcineurin 1
 7045
 0.23
chr17_76880061_76880570 0.19 TIMP2
 TIMP metallopeptidase inhibitor 2
 10083
 0.14
chr17_36621594_36621757 0.19 ARHGAP23
 Rho GTPase activating protein 23
 6505
 0.17
chr19_13135028_13135217 0.19 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
 272
 0.84
chr14_23538007_23538158 0.19 ACIN1
 apoptotic chromatin condensation inducer 1
 2665
 0.13
chr5_14171520_14171879 0.19 TRIO
 trio Rho guanine nucleotide exchange factor
 12208
 0.31
chr4_81118792_81119547 0.19 PRDM8
 PR domain containing 8
 511
 0.82
chr6_5208630_5208872 0.19 ENSG00000264541
 .
 16279
 0.2
chr2_64539316_64539525 0.18 ENSG00000264297
 .
 28473
 0.21
chr5_173207490_173207641 0.18 ENSG00000263401
 .
 50484
 0.16
chr21_36254420_36254945 0.18 RUNX1
 runt-related transcription factor 1
 4798
 0.34
chr2_69405192_69405451 0.18 ENSG00000251850
 .
 3814
 0.24
chr18_56665001_56665175 0.18 ENSG00000251870
 .
 71560
 0.1
chr6_33180748_33181418 0.18 RING1
 ring finger protein 1
 4811
 0.08
chr11_117069900_117070051 0.18 TAGLN
 transgelin
 62
 0.96
chr9_128235766_128235975 0.18 MAPKAP1
 mitogen-activated protein kinase associated protein 1
 10910
 0.23
chr5_127447715_127447866 0.18 SLC12A2
 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
 28250
 0.26
chr11_64389104_64389255 0.18 NRXN2
 neurexin 2
 20979
 0.13
chr4_185744284_185744435 0.18 ACSL1
 acyl-CoA synthetase long-chain family member 1
 2829
 0.25
chr11_110967368_110967519 0.18 ENSG00000200168
 .
 56511
 0.15
chr1_98569393_98569544 0.18 ENSG00000225206
 .
 57741
 0.17
chr9_14320711_14320862 0.18 NFIB
 nuclear factor I/B
 1551
 0.46
chr18_65661971_65662168 0.18 DSEL
 dermatan sulfate epimerase-like
 477852
 0.01
chrX_152761685_152761943 0.18 HAUS7
 HAUS augmin-like complex, subunit 7
 836
 0.41
chr4_55100810_55101099 0.17 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
 4465
 0.31
chr10_97501950_97502206 0.17 ENTPD1
 ectonucleoside triphosphate diphosphohydrolase 1
 13331
 0.21
chr6_152701268_152701555 0.17 SYNE1-AS1
 SYNE1 antisense RNA 1
 270
 0.91
chr4_24796744_24797030 0.17 SOD3
 superoxide dismutase 3, extracellular
 198
 0.97
chr20_34025363_34025770 0.17 GDF5
 growth differentiation factor 5
 457
 0.71
chr8_99007536_99007844 0.17 MATN2
 matrilin 2
 21082
 0.15
chr15_96869088_96869239 0.17 NR2F2
 nuclear receptor subfamily 2, group F, member 2
 4
 0.96
chr17_58821066_58821723 0.17 ENSG00000252534
 .
 5013
 0.22
chr4_23892235_23892469 0.17 PPARGC1A
 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
 652
 0.82
chr8_29107320_29107471 0.17 KIF13B
 kinesin family member 13B
 13195
 0.17
chr6_2468845_2468996 0.17 ENSG00000266252
 .
 59051
 0.15
chr15_68573463_68573639 0.17 FEM1B
 fem-1 homolog b (C. elegans)
 1254
 0.47
chr16_87481635_87481786 0.17 ZCCHC14
 zinc finger, CCHC domain containing 14
 14970
 0.16
chr14_75688794_75688945 0.17 ENSG00000252013
 .
 19997
 0.14
chr6_3749707_3750198 0.17 RP11-420L9.5
1393
 0.41
chr18_395366_395517 0.17 RP11-720L2.2
28975
 0.2
chr2_109257559_109258085 0.17 LIMS1
 LIM and senescent cell antigen-like domains 1
 13446
 0.22
chr17_56031961_56032485 0.17 CUEDC1
 CUE domain containing 1
 395
 0.83
chr5_73109422_73109633 0.17 ARHGEF28
 Rho guanine nucleotide exchange factor (GEF) 28
 184
 0.95
chr15_63305654_63305860 0.16 TPM1
 tropomyosin 1 (alpha)
 29074
 0.16
chr5_150284813_150285011 0.16 ZNF300
 zinc finger protein 300
 367
 0.87
chrX_45613808_45613959 0.16 ENSG00000207725
 .
 7353
 0.25
chr4_95332017_95332168 0.16 PDLIM5
 PDZ and LIM domain 5
 40945
 0.2
chr11_34675128_34675279 0.16 EHF
 ets homologous factor
 11029
 0.28
chr1_16212355_16212620 0.16 SPEN
 spen family transcriptional repressor
 9416
 0.15
chr6_166532528_166532679 0.16 ENSG00000231297
 .
 19262
 0.22
chr22_27105780_27105987 0.16 CRYBA4
 crystallin, beta A4
 87955
 0.08
chr16_3309520_3309673 0.16 MEFV
 Mediterranean fever
 2969
 0.14
chr3_72287415_72287566 0.16 ENSG00000212070
 .
 24089
 0.27
chr2_234151079_234151230 0.16 ATG16L1
 autophagy related 16-like 1 (S. cerevisiae)
 9063
 0.15
chr22_39260401_39260552 0.16 CBX6
 chromobox homolog 6
 7745
 0.14
chr6_16849709_16849927 0.16 RP1-151F17.1
87675
 0.09
chr18_37379955_37380106 0.16 ENSG00000212354
 .
 121444
 0.06
chr2_33391334_33391485 0.16 LTBP1
 latent transforming growth factor beta binding protein 1
 31685
 0.23
chrX_34673939_34674563 0.16 TMEM47
 transmembrane protein 47
 1154
 0.68
chr1_68215659_68215876 0.16 ENSG00000238778
 .
 22569
 0.2
chr1_29066466_29066617 0.16 YTHDF2
 YTH domain family, member 2
 3064
 0.23
chr21_34677268_34677419 0.16 IFNAR1
 interferon (alpha, beta and omega) receptor 1
 19391
 0.14
chr2_99767240_99767391 0.16 TSGA10
 testis specific, 10
 4065
 0.14
chr4_186425617_186425867 0.16 PDLIM3
 PDZ and LIM domain 3
 30914
 0.12
chr2_20001539_20001690 0.16 TTC32
 tetratricopeptide repeat domain 32
 99788
 0.08
chr2_102321542_102321693 0.16 MAP4K4
 mitogen-activated protein kinase kinase kinase kinase 4
 6625
 0.32
chr8_91996797_91997429 0.16 C8orf88
 chromosome 8 open reading frame 88
 372
 0.85
chr14_55239224_55239463 0.15 SAMD4A
 sterile alpha motif domain containing 4A
 17792
 0.24
chr8_57595049_57595246 0.15 RP11-17A4.2
193490
 0.03
chr16_1664599_1665551 0.15 CRAMP1L
 Crm, cramped-like (Drosophila)
 434
 0.69
chr20_58516772_58516923 0.15 FAM217B
 family with sequence similarity 217, member B
 332
 0.82
chr5_115313493_115313761 0.15 AQPEP
 Aminopeptidase Q
 15436
 0.17
chr2_199237110_199237329 0.15 ENSG00000252511
 .
 194234
 0.03
chr21_15921425_15921576 0.15 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 2836
 0.33
chr6_138170630_138170781 0.15 RP11-356I2.4
8480
 0.22
chr3_150089259_150089633 0.15 TSC22D2
 TSC22 domain family, member 2
 36676
 0.21
chr6_164530063_164530741 0.15 ENSG00000266128
 .
 268809
 0.02
chr5_146933859_146934303 0.15 DPYSL3
 dihydropyrimidinase-like 3
 44462
 0.19
chr1_23066485_23066803 0.15 ENSG00000216157
 .
 8760
 0.17
chr11_63438034_63439177 0.15 ATL3
 atlastin GTPase 3
 479
 0.76
chr2_160418896_160419047 0.15 ENSG00000207117
 .
 26114
 0.19
chr1_63590436_63590751 0.15 ENSG00000252259
 .
 61528
 0.14
chr4_79473579_79473973 0.15 ANXA3
 annexin A3
 655
 0.79
chr2_175203738_175203889 0.15 AC018470.1
 Uncharacterized protein FLJ46347
 1662
 0.32
chr10_104817675_104817826 0.15 NT5C2
 5'-nucleotidase, cytosolic II
 36375
 0.18
chr8_38264174_38264701 0.15 RP11-350N15.6
1823
 0.22
chrX_47142357_47142518 0.15 ENSG00000266158
 .
 1975
 0.25
chr8_122419386_122419537 0.14 ENSG00000263525
 .
 135774
 0.05
chr7_5710455_5710606 0.14 RNF216-IT1
 RNF216 intronic transcript 1 (non-protein coding)
 9562
 0.21
chr5_53358972_53359145 0.14 ENSG00000265421
 .
 12355
 0.22
chr11_59021844_59021995 0.14 ENSG00000263944
 .
 36887
 0.12
chr5_157911190_157911341 0.14 CTD-2363C16.1
498749
 0.0
chr14_21564786_21565064 0.14 ZNF219
 zinc finger protein 219
 1874
 0.17
chr2_85504683_85504834 0.14 ENSG00000221579
 .
 21399
 0.12
chr12_112560647_112560960 0.14 TRAFD1
 TRAF-type zinc finger domain containing 1
 2502
 0.22
chrX_10851859_10852068 0.14 MID1
 midline 1 (Opitz/BBB syndrome)
 190
 0.97
chr9_99249166_99249317 0.14 HABP4
 hyaluronan binding protein 4
 36754
 0.17
chr20_61817533_61817684 0.14 ENSG00000207598
 .
 7756
 0.14
chr1_225635412_225635563 0.14 RP11-496N12.6
17498
 0.17
chr19_11650748_11650916 0.14 CNN1
 calponin 1, basic, smooth muscle
 123
 0.92

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.1 0.2 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.4 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.1 0.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.2 GO:0031223 auditory behavior(GO:0031223)
0.1 0.2 GO:0072081 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.1 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.2 GO:0009296 obsolete flagellum assembly(GO:0009296)
0.0 0.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.2 GO:0060347 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.3 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.1 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.0 0.1 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 0.1 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.0 GO:0031033 myosin filament organization(GO:0031033)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.2 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.1 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.1 GO:0003078 obsolete regulation of natriuresis(GO:0003078)
0.0 0.1 GO:0071694 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.1 GO:2001280 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.2 GO:0036296 response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0 0.2 GO:0010830 regulation of myotube differentiation(GO:0010830)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.2 GO:0006555 methionine metabolic process(GO:0006555)
0.0 0.0 GO:0032616 interleukin-13 production(GO:0032616)
0.0 0.2 GO:0019430 removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.0 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.0 GO:0001714 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.0 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.0 GO:0003148 outflow tract septum morphogenesis(GO:0003148)
0.0 0.1 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0 0.1 GO:0009886 post-embryonic morphogenesis(GO:0009886)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.0 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.0 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.0 0.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.0 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.0 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.0 GO:0060751 branch elongation involved in mammary gland duct branching(GO:0060751)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0032288 myelin assembly(GO:0032288)
0.0 0.2 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.0 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.1 GO:0033085 negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399)
0.0 0.0 GO:0048569 post-embryonic organ development(GO:0048569)
0.0 0.5 GO:0034339 obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor(GO:0034339)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.2 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.1 GO:0030992 intraciliary transport particle(GO:0030990) intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016151 nickel cation binding(GO:0016151)
0.1 0.7 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.1 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0001159 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.2 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.3 GO:0051378 serotonin binding(GO:0051378)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.2 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0001077 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.0 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.0 GO:0019863 IgE binding(GO:0019863)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.6 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.2 GO:0017022 myosin binding(GO:0017022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.0 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.5 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME SIGNALING BY ILS Genes involved in Signaling by Interleukins
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.3 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway