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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SRY

Z-value: 0.25

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Transcription factors associated with SRY

Gene Symbol	Gene ID	Gene Info
SRY Ensembl NCBI GeneCards UniProt	ENSG00000184895.6	SRY

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SRY	chrY_2655519_2655670	50	0.977279	-0.81	7.5e-03	Click!
SRY	chrY_2654987_2655138	582	0.749452	-0.77	1.6e-02	Click!
SRY	chrY_2655183_2655334	386	0.861759	-0.51	1.6e-01	Click!

Activity of the SRY motif across conditions

Conditions sorted by the z-value of the SRY motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_209930701_209930998	0.07	TRAF3IP3	TRAF3 interacting protein 3	994	0.46
chr7_37448490_37448719	0.07	ENSG00000200113	.	10627	0.2
chr2_204571383_204571580	0.06	CD28	CD28 molecule	65	0.98
chr13_74806186_74806399	0.05	ENSG00000206617	.	57059	0.16
chr1_160547631_160547822	0.05	CD84	CD84 molecule	1537	0.33
chrX_30594869_30596024	0.05	CXorf21	chromosome X open reading frame 21	515	0.84
chr15_81594027_81594306	0.05	IL16	interleukin 16	2409	0.29
chr13_31309749_31309959	0.05	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	209	0.96
chr3_71542168_71542650	0.05	ENSG00000221264	.	48831	0.15
chr3_151911560_151911983	0.05	MBNL1	muscleblind-like splicing regulator 1	74058	0.11
chr12_47607778_47608233	0.05	PCED1B	PC-esterase domain containing 1B	2047	0.36
chr3_60062649_60062918	0.05	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	105200	0.08
chr3_111266223_111266431	0.05	CD96	CD96 molecule	5330	0.28
chr6_143163152_143163303	0.05	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	5043	0.32
chr7_150264558_150265605	0.05	GIMAP4	GTPase, IMAP family member 4	557	0.78
chrX_48773434_48773585	0.05	PIM2	pim-2 oncogene	497	0.64
chr6_108143523_108143878	0.04	SCML4	sex comb on midleg-like 4 (Drosophila)	1816	0.46
chr7_149572287_149572438	0.04	ATP6V0E2	ATPase, H+ transporting V0 subunit e2	1230	0.35
chr3_3214293_3214763	0.04	CRBN	cereblon	6830	0.19
chr13_99959249_99959863	0.04	GPR183	G protein-coupled receptor 183	103	0.97
chr9_95728150_95728303	0.04	FGD3	FYVE, RhoGEF and PH domain containing 3	1983	0.37
chr2_161995820_161996335	0.04	TANK	TRAF family member-associated NFKB activator	2611	0.33
chr6_26404189_26404392	0.04	BTN3A1	butyrophilin, subfamily 3, member A1	1767	0.21
chr12_110517460_110517751	0.04	C12orf76	chromosome 12 open reading frame 76	6114	0.22
chr5_35852941_35853144	0.04	IL7R	interleukin 7 receptor	245	0.93
chr10_12408131_12408282	0.04	CAMK1D	calcium/calmodulin-dependent protein kinase ID	16474	0.18
chr12_109028220_109028371	0.04	SELPLG	selectin P ligand	560	0.6
chr1_111421280_111421431	0.04	CD53	CD53 molecule	5579	0.21
chr2_197032904_197033284	0.04	STK17B	serine/threonine kinase 17b	2630	0.28
chr5_130882612_130883040	0.04	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	14100	0.29
chr2_87799012_87799242	0.04	RP11-1399P15.1		21574	0.26
chr10_22944496_22944670	0.04	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	58454	0.15
chr7_106507057_106507208	0.04	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1208	0.59
chr1_212769581_212769895	0.04	ATF3	activating transcription factor 3	12274	0.15
chrX_135862199_135862350	0.04	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	1973	0.31
chr7_137619960_137620169	0.04	CREB3L2	cAMP responsive element binding protein 3-like 2	1428	0.46
chr2_225266563_225267117	0.04	FAM124B	family with sequence similarity 124B	38	0.99
chr14_53593361_53593728	0.04	DDHD1	DDHD domain containing 1	23260	0.17
chr3_151922152_151922513	0.04	MBNL1	muscleblind-like splicing regulator 1	63497	0.12
chr13_52395252_52395592	0.04	RP11-327P2.5		16989	0.18
chr18_72939308_72939459	0.04	TSHZ1	teashirt zinc finger homeobox 1	6370	0.26
chr12_25207808_25208034	0.04	LRMP	lymphoid-restricted membrane protein	2247	0.32
chr2_174793227_174793378	0.04	SP3	Sp3 transcription factor	35645	0.23
chr9_71396707_71396872	0.04	FAM122A	family with sequence similarity 122A	1825	0.41
chr1_100820231_100820573	0.04	CDC14A	cell division cycle 14A	1897	0.33
chr6_154570961_154571273	0.04	IPCEF1	interaction protein for cytohesin exchange factors 1	2301	0.45
chr4_11473602_11473900	0.04	HS3ST1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	42362	0.18
chrX_70415693_70415844	0.04	RP5-1091N2.9		2257	0.22
chr4_199492_199643	0.04	ZNF876P	zinc finger protein 876, pseudogene	12872	0.19
chr10_17726067_17726351	0.04	ENSG00000251959	.	5022	0.18
chr12_47609896_47610314	0.04	PCED1B	PC-esterase domain containing 1B	53	0.98
chr2_201985519_201985852	0.04	CFLAR	CASP8 and FADD-like apoptosis regulator	1515	0.3
chr17_75663137_75663644	0.04	SEPT9	septin 9	185395	0.03
chr1_234536476_234536730	0.04	COA6	cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)	27156	0.13
chr14_88472278_88472651	0.04	GPR65	G protein-coupled receptor 65	996	0.51
chr2_144016827_144016978	0.04	RP11-190J23.1		87161	0.1
chr1_231113322_231113566	0.04	TTC13	tetratricopeptide repeat domain 13	1098	0.34
chr7_140176949_140177100	0.04	MKRN1	makorin ring finger protein 1	1279	0.46
chr17_38021542_38021693	0.04	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1176	0.38
chr4_153431598_153431794	0.04	ENSG00000264678	.	21128	0.17
chr9_3528863_3529151	0.03	RFX3	regulatory factor X, 3 (influences HLA class II expression)	3003	0.37
chr15_31623203_31623354	0.03	KLF13	Kruppel-like factor 13	4220	0.35
chr8_66751055_66751459	0.03	PDE7A	phosphodiesterase 7A	274	0.95
chr2_197029492_197029688	0.03	STK17B	serine/threonine kinase 17b	6134	0.21
chr12_15110215_15110471	0.03	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	3857	0.2
chr13_41589998_41590808	0.03	ELF1	E74-like factor 1 (ets domain transcription factor)	3047	0.26
chr2_158274562_158274945	0.03	CYTIP	cytohesin 1 interacting protein	21173	0.2
chr12_10019991_10020525	0.03	RP11-290C10.1		632	0.61
chr3_16929685_16929836	0.03	PLCL2	phospholipase C-like 2	3308	0.33
chr5_158302747_158302898	0.03	CTD-2363C16.1		107192	0.07
chr12_92531544_92532018	0.03	C12orf79	chromosome 12 open reading frame 79	984	0.53
chr13_95923472_95923623	0.03	ABCC4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	30042	0.17
chr14_45719805_45719966	0.03	MIS18BP1	MIS18 binding protein 1	2495	0.3
chr14_22594490_22594692	0.03	ENSG00000238634	.	16296	0.27
chrX_21942836_21942987	0.03	SMS	spermine synthase	15780	0.2
chr3_42679974_42680125	0.03	ZBTB47	zinc finger and BTB domain containing 47	15127	0.1
chr1_198620283_198620434	0.03	PTPRC	protein tyrosine phosphatase, receptor type, C	12066	0.23
chr2_112208811_112209043	0.03	ENSG00000266139	.	130259	0.06
chr6_90789489_90789772	0.03	ENSG00000222078	.	78405	0.1
chr18_72873277_72873679	0.03	ZADH2	zinc binding alcohol dehydrogenase domain containing 2	43990	0.18
chr1_167483086_167483237	0.03	CD247	CD247 molecule	4614	0.23
chr5_56594977_56595231	0.03	GPBP1	GC-rich promoter binding protein 1	85146	0.09
chr4_68410033_68410229	0.03	CENPC	centromere protein C	1193	0.53
chr12_56754222_56754408	0.03	STAT2	signal transducer and activator of transcription 2, 113kDa	405	0.67
chr5_139948767_139948946	0.03	SLC35A4	solute carrier family 35, member A4	4380	0.09
chr6_2222723_2222882	0.03	GMDS	GDP-mannose 4,6-dehydratase	23124	0.28
chr14_52784141_52784292	0.03	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	3103	0.33
chr1_198492691_198493057	0.03	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	16930	0.28
chr1_158980454_158980701	0.03	IFI16	interferon, gamma-inducible protein 16	777	0.67
chr1_239880855_239881135	0.03	ENSG00000233355	.	1371	0.43
chr12_12874334_12874808	0.03	RP11-180M15.4		2374	0.2
chr12_68024269_68024420	0.03	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	17774	0.25
chr8_113941673_113941824	0.03	CSMD3	CUB and Sushi multiple domains 3	239477	0.02
chr11_5246233_5246455	0.03	ENSG00000221031	.	475	0.58
chr21_36341148_36341299	0.03	RUNX1	runt-related transcription factor 1	79136	0.12
chr19_16482667_16482930	0.03	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	10034	0.15
chr6_143228096_143228637	0.03	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	37972	0.2
chr13_77899440_77899640	0.03	MYCBP2	MYC binding protein 2, E3 ubiquitin protein ligase	1274	0.61
chr6_112080304_112080455	0.03	FYN	FYN oncogene related to SRC, FGR, YES	45	0.99
chr2_45794731_45794926	0.03	SRBD1	S1 RNA binding domain 1	326	0.88
chr17_29158361_29158512	0.03	ATAD5	ATPase family, AAA domain containing 5	552	0.65
chr2_223654006_223654270	0.03	ACSL3	acyl-CoA synthetase long-chain family member 3	71514	0.1
chr12_118796178_118796667	0.03	TAOK3	TAO kinase 3	488	0.85
chr10_52396469_52396620	0.03	SGMS1	sphingomyelin synthase 1	11749	0.18
chr8_23312529_23312889	0.03	ENTPD4	ectonucleoside triphosphate diphosphohydrolase 4	2451	0.28
chr17_7790433_7790660	0.03	CHD3	chromodomain helicase DNA binding protein 3	1563	0.19
chr1_109103821_109104099	0.03	FAM102B	family with sequence similarity 102, member B	1249	0.55
chr12_47601705_47601886	0.03	PCED1B	PC-esterase domain containing 1B	8257	0.22
chr15_75072904_75073055	0.03	CSK	c-src tyrosine kinase	1419	0.29
chr6_143178538_143178701	0.03	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	20435	0.26
chrY_23417410_23417561	0.03	CYorf17	chromosome Y open reading frame 17	130761	0.05
chr7_45980495_45980766	0.03	IGFBP3	insulin-like growth factor binding protein 3	19157	0.18
chr10_31287543_31287794	0.03	ZNF438	zinc finger protein 438	778	0.75
chr4_114684033_114684430	0.03	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	1148	0.66
chr2_20549100_20549748	0.03	PUM2	pumilio RNA-binding family member 2	958	0.54
chr5_39177582_39177762	0.03	FYB	FYN binding protein	25457	0.23
chr3_159628787_159629360	0.03	SCHIP1	schwannomin interacting protein 1	58345	0.11
chrX_78620075_78620267	0.03	ITM2A	integral membrane protein 2A	2685	0.44
chr12_3982064_3982233	0.03	PARP11	poly (ADP-ribose) polymerase family, member 11	373	0.82
chr14_22977314_22977663	0.03	TRAJ15	T cell receptor alpha joining 15	21092	0.09
chr5_67515061_67515212	0.03	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	3532	0.3
chr19_42390602_42391041	0.03	ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	2306	0.19
chr2_204803308_204803520	0.03	ICOS	inducible T-cell co-stimulator	1911	0.46
chr6_159074554_159074705	0.03	SYTL3	synaptotagmin-like 3	3583	0.22
chr15_81586254_81586487	0.03	IL16	interleukin 16	2884	0.28
chr12_104888025_104888586	0.03	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	37526	0.2
chr14_71110053_71110301	0.03	TTC9	tetratricopeptide repeat domain 9	1673	0.4
chr10_76728189_76728340	0.03	RP11-77G23.5		55745	0.12
chr14_91524676_91524827	0.03	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	1727	0.3
chr7_5694530_5694681	0.03	RNF216-IT1	RNF216 intronic transcript 1 (non-protein coding)	25487	0.16
chrX_149739512_149739787	0.03	MTM1	myotubularin 1	2556	0.37
chr4_71860383_71860569	0.03	DCK	deoxycytidine kinase	1121	0.6
chr10_70748146_70748533	0.03	KIAA1279	KIAA1279	148	0.95
chr5_56113673_56113824	0.03	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	2347	0.29
chr12_11804572_11805680	0.03	ETV6	ets variant 6	2338	0.4
chr4_40205321_40205527	0.03	RHOH	ras homolog family member H	3460	0.27
chr16_87889915_87890443	0.03	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5	7066	0.18
chr5_137911540_137911767	0.03	HSPA9	heat shock 70kDa protein 9 (mortalin)	520	0.71
chr14_22994017_22994177	0.03	TRAJ15	T cell receptor alpha joining 15	4483	0.13
chr2_55236798_55237891	0.03	RTN4	reticulon 4	241	0.93
chr19_42038250_42038705	0.03	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	17409	0.15
chr2_109239891_109240042	0.03	LIMS1	LIM and senescent cell antigen-like domains 1	2244	0.37
chr12_15716958_15717148	0.03	PTPRO	protein tyrosine phosphatase, receptor type, O	16644	0.26
chr2_231921398_231921578	0.03	PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	90	0.96
chr22_38793751_38794050	0.03	CSNK1E	casein kinase 1, epsilon	627	0.62
chr14_38558222_38558398	0.03	CTD-2058B24.2		2053	0.43
chr16_22383541_22383722	0.03	CDR2	cerebellar degeneration-related protein 2, 62kDa	2307	0.21
chr16_71851540_71851781	0.03	AP1G1	adaptor-related protein complex 1, gamma 1 subunit	8556	0.13
chr16_84793452_84793603	0.03	USP10	ubiquitin specific peptidase 10	8344	0.22
chr19_12061488_12061639	0.03	ZNF700	zinc finger protein 700	3994	0.13
chr7_150374007_150374169	0.03	GIMAP2	GTPase, IMAP family member 2	8700	0.17
chr1_52014581_52014732	0.03	ENSG00000252032	.	10255	0.16
chrX_74376165_74376390	0.03	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	145	0.97
chr16_46722355_46722638	0.03	VPS35	vacuolar protein sorting 35 homolog (S. cerevisiae)	608	0.58
chr5_37198039_37198190	0.03	C5orf42	chromosome 5 open reading frame 42	15610	0.24
chr7_28369849_28370167	0.03	CREB5	cAMP responsive element binding protein 5	31068	0.23
chr15_86125606_86125830	0.03	RP11-815J21.2		2309	0.27
chr8_8706094_8706267	0.03	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	44975	0.14
chr12_11805836_11806191	0.03	ETV6	ets variant 6	3225	0.34
chr2_43448588_43448818	0.03	ZFP36L2	ZFP36 ring finger protein-like 2	5045	0.26
chr2_198169566_198169717	0.03	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	2398	0.25
chrX_78417033_78417184	0.03	GPR174	G protein-coupled receptor 174	9361	0.32
chr8_17554451_17554629	0.03	MTUS1	microtubule associated tumor suppressor 1	639	0.69
chr10_14604221_14604372	0.03	FAM107B	family with sequence similarity 107, member B	6117	0.27
chr2_202127394_202127951	0.02	CASP8	caspase 8, apoptosis-related cysteine peptidase	993	0.56
chr13_41557045_41557196	0.02	ELF1	E74-like factor 1 (ets domain transcription factor)	702	0.71
chr3_107319287_107319503	0.02	BBX	bobby sox homolog (Drosophila)	1235	0.65
chr9_32525867_32526215	0.02	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	152	0.95
chr4_76598858_76599149	0.02	G3BP2	GTPase activating protein (SH3 domain) binding protein 2	150	0.95
chr3_151989912_151990063	0.02	MBNL1-AS1	MBNL1 antisense RNA 1	2643	0.28
chr8_41649611_41650018	0.02	ANK1	ankyrin 1, erythrocytic	5326	0.2
chr4_80886303_80886454	0.02	ANTXR2	anthrax toxin receptor 2	107339	0.07
chr2_198102391_198102542	0.02	ANKRD44	ankyrin repeat domain 44	39704	0.14
chr2_37844911_37845062	0.02	AC006369.2		17707	0.22
chr4_38857928_38858431	0.02	TLR6	toll-like receptor 6	258	0.48
chr9_35276767_35276918	0.02	AL160274.1	HCG17281; PRO0038; Uncharacterized protein	84420	0.07
chr13_48809687_48810120	0.02	ITM2B	integral membrane protein 2B	2564	0.37
chr5_64447748_64447899	0.02	ENSG00000207439	.	28627	0.26
chr6_152622546_152623206	0.02	SYNE1	spectrin repeat containing, nuclear envelope 1	382	0.91
chr21_36413445_36413809	0.02	RUNX1	runt-related transcription factor 1	7835	0.33
chr6_150739556_150740117	0.02	IYD	iodotyrosine deiodinase	48723	0.16
chrX_153626756_153627188	0.02	RPL10	ribosomal protein L10	253	0.78
chr21_48025776_48026061	0.02	S100B	S100 calcium binding protein B	797	0.66
chr1_25663249_25663400	0.02	TMEM50A	transmembrane protein 50A	1084	0.32
chr2_87883698_87883984	0.02	ENSG00000265507	.	45433	0.18
chr7_15214941_15215142	0.02	AGMO	alkylglycerol monooxygenase	190771	0.03
chr2_214148558_214149019	0.02	SPAG16	sperm associated antigen 16	325	0.94
chr1_230201927_230202153	0.02	GALNT2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	916	0.66
chr5_32171141_32171315	0.02	GOLPH3	golgi phosphoprotein 3 (coat-protein)	3228	0.25
chr15_86098904_86099149	0.02	AKAP13	A kinase (PRKA) anchor protein 13	349	0.88
chr12_15104822_15105163	0.02	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	907	0.54
chr19_16493261_16493427	0.02	ENSG00000243745	.	16426	0.13
chr9_94877804_94877985	0.02	SPTLC1	serine palmitoyltransferase, long chain base subunit 1	229	0.94
chr11_73690068_73690219	0.02	UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	957	0.48
chr5_131310633_131310784	0.02	ACSL6	acyl-CoA synthetase long-chain family member 6	19210	0.13
chr12_62656333_62656484	0.02	USP15	ubiquitin specific peptidase 15	2199	0.3
chr1_102637571_102637722	0.02	OLFM3	olfactomedin 3	175060	0.04
chr12_32113022_32113222	0.02	KIAA1551	KIAA1551	769	0.71
chr19_17493496_17493698	0.02	PLVAP	plasmalemma vesicle associated protein	5438	0.09
chr17_33400509_33400660	0.02	RFFL	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	9713	0.1

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SRY

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.0	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0050544	arachidonic acid binding(GO:0050544)