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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for STAT1_STAT3_BCL6

Z-value: 0.50

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Transcription factors associated with STAT1_STAT3_BCL6

Gene Symbol Gene ID Gene Info
STAT1
ENSG00000115415.14 signal transducer and activator of transcription 1
STAT3
ENSG00000168610.10 signal transducer and activator of transcription 3
BCL6
ENSG00000113916.13 BCL6 transcription repressor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr3_187520878_187521148BCL6574980.139536-0.862.9e-03Click!
chr3_187456856_187457007BCL611990.515166-0.835.1e-03Click!
chr3_187485668_187485819BCL6222280.2133820.817.7e-03Click!
chr3_187637243_187637630BCL61739210.031913-0.771.5e-02Click!
chr3_187454096_187454438BCL6900.9741230.732.6e-02Click!
chr2_191876732_191876887STAT115040.371062-0.872.4e-03Click!
chr2_191877453_191877604STAT17850.612427-0.872.5e-03Click!
chr2_191877633_191877798STAT15980.715316-0.853.7e-03Click!
chr2_191877894_191878160STAT12860.895648-0.771.5e-02Click!
chr2_191876019_191876170STAT122190.276694-0.665.1e-02Click!
chr17_40507445_40507596STAT3329120.0943540.732.6e-02Click!
chr17_40516095_40516246STAT3242620.1067980.732.7e-02Click!
chr17_40540908_40541151STAT34430.738460-0.521.5e-01Click!
chr17_40534451_40534602STAT359060.1318940.511.6e-01Click!
chr17_40535679_40535830STAT346780.1393980.452.2e-01Click!

Activity of the STAT1_STAT3_BCL6 motif across conditions

Conditions sorted by the z-value of the STAT1_STAT3_BCL6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr8_104384541_104384884 0.34 CTHRC1
 collagen triple helix repeat containing 1
 51
 0.97
chr2_66802213_66802500 0.32 MEIS1
 Meis homeobox 1
 66297
 0.13
chrX_67913478_67914353 0.30 STARD8
 StAR-related lipid transfer (START) domain containing 8
 422
 0.91
chr9_124320076_124320249 0.30 DAB2IP
 DAB2 interacting protein
 9174
 0.18
chr12_2163640_2163867 0.27 CACNA1C
 calcium channel, voltage-dependent, L type, alpha 1C subunit
 1024
 0.49
chr12_53443889_53444561 0.27 TENC1
 tensin like C1 domain containing phosphatase (tensin 2)
 255
 0.86
chr5_15620667_15620944 0.27 FBXL7
 F-box and leucine-rich repeat protein 7
 4714
 0.28
chrX_34673666_34673817 0.27 TMEM47
 transmembrane protein 47
 1664
 0.56
chr15_63337269_63337696 0.25 TPM1
 tropomyosin 1 (alpha)
 1507
 0.37
chrX_114467670_114468385 0.24 LRCH2
 leucine-rich repeats and calponin homology (CH) domain containing 2
 601
 0.77
chr3_145968965_145969195 0.24 PLSCR4
 phospholipid scramblase 4
 114
 0.98
chr14_73929626_73929971 0.24 ENSG00000251393
 .
 669
 0.64
chr1_186649638_186650434 0.23 PTGS2
 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
 477
 0.89
chr14_55239224_55239463 0.23 SAMD4A
 sterile alpha motif domain containing 4A
 17792
 0.24
chr7_38624277_38624485 0.23 AMPH
 amphiphysin
 46639
 0.16
chr2_38303069_38303895 0.23 CYP1B1-AS1
 CYP1B1 antisense RNA 1
 156
 0.5
chr5_33891044_33891453 0.23 ADAMTS12
 ADAM metallopeptidase with thrombospondin type 1 motif, 12
 798
 0.63
chr17_42214986_42215221 0.22 ENSG00000212446
 .
 1746
 0.18
chr17_38096107_38096317 0.22 LRRC3C
 leucine rich repeat containing 3C
 1515
 0.27
chr1_162472131_162472282 0.22 UHMK1
 U2AF homology motif (UHM) kinase 1
 4573
 0.22
chr7_100200266_100200615 0.22 PCOLCE-AS1
 PCOLCE antisense RNA 1
 218
 0.74
chr3_55519561_55519953 0.22 WNT5A
 wingless-type MMTV integration site family, member 5A
 1574
 0.4
chr2_14775112_14775752 0.21 AC011897.1
 Uncharacterized protein
 217
 0.95
chr10_42862871_42863499 0.21 RP11-313J2.1
14726
 0.27
chr15_48960228_48960461 0.21 FBN1
 fibrillin 1
 22298
 0.23
chr22_24721245_24721396 0.21 SPECC1L
 sperm antigen with calponin homology and coiled-coil domains 1-like
 20956
 0.18
chr6_125285262_125285420 0.20 RP11-510H23.1
1156
 0.45
chr16_3432471_3432622 0.20 MTRNR2L4
 MT-RNR2-like 4
 10263
 0.11
chr6_16318510_16318713 0.20 GMPR
 guanosine monophosphate reductase
 79800
 0.09
chr13_32520909_32521060 0.20 EEF1DP3
 eukaryotic translation elongation factor 1 delta pseudogene 3
 5733
 0.3
chr4_170188382_170188561 0.20 SH3RF1
 SH3 domain containing ring finger 1
 2637
 0.38
chr8_136471145_136471318 0.20 KHDRBS3
 KH domain containing, RNA binding, signal transduction associated 3
 281
 0.92
chr5_167696137_167696498 0.20 WWC1
 WW and C2 domain containing 1
 22339
 0.2
chr7_132299406_132299928 0.20 PLXNA4
 plexin A4
 33780
 0.18
chr2_218874347_218874698 0.20 TNS1
 tensin 1
 6804
 0.19
chr4_175750179_175750687 0.19 GLRA3
 glycine receptor, alpha 3
 32
 0.99
chr6_3749707_3750198 0.19 RP11-420L9.5
1393
 0.41
chr12_56138916_56139328 0.19 GDF11
 growth differentiation factor 11
 1939
 0.16
chr12_77625749_77626115 0.19 ENSG00000238769
 .
 69127
 0.14
chr10_91055374_91055594 0.19 IFIT2
 interferon-induced protein with tetratricopeptide repeats 2
 6228
 0.15
chr9_123698545_123698822 0.19 TRAF1
 TNF receptor-associated factor 1
 7232
 0.23
chr12_81471441_81472090 0.19 ACSS3
 acyl-CoA synthetase short-chain family member 3
 71
 0.98
chr19_55684291_55685412 0.19 SYT5
 synaptotagmin V
 1083
 0.28
chr2_223163063_223163341 0.19 PAX3
 paired box 3
 263
 0.57
chr3_136558029_136558180 0.18 RP11-731C17.2
241
 0.91
chr2_159825200_159826543 0.18 TANC1
 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
 688
 0.73
chr9_21764802_21765039 0.18 MTAP
 methylthioadenosine phosphorylase
 37622
 0.15
chr3_123602332_123603013 0.18 MYLK
 myosin light chain kinase
 477
 0.85
chr5_82768204_82768925 0.18 VCAN
 versican
 820
 0.75
chr5_150181351_150181502 0.18 AC010441.1
23559
 0.14
chr15_39871853_39872515 0.18 THBS1
 thrombospondin 1
 1096
 0.52
chr10_121529608_121529837 0.18 ENSG00000242818
 .
 1963
 0.36
chr15_50352056_50352408 0.18 ATP8B4
 ATPase, class I, type 8B, member 4
 12648
 0.24
chr11_65639318_65639911 0.18 EFEMP2
 EGF containing fibulin-like extracellular matrix protein 2
 511
 0.56
chr18_34275433_34275584 0.18 FHOD3
 formin homology 2 domain containing 3
 23012
 0.23
chr7_134540880_134541057 0.18 CALD1
 caldesmon 1
 10624
 0.29
chr5_65893484_65893635 0.18 MAST4
 microtubule associated serine/threonine kinase family member 4
 1075
 0.66
chr17_21452935_21453464 0.18 C17orf51
 chromosome 17 open reading frame 51
 1744
 0.38
chr17_57504883_57505034 0.17 RP11-567L7.5
24294
 0.18
chr12_8090559_8091101 0.17 SLC2A3
 solute carrier family 2 (facilitated glucose transporter), member 3
 1959
 0.27
chr8_101555325_101555476 0.17 ANKRD46
 ankyrin repeat domain 46
 9847
 0.18
chr4_142003365_142003602 0.17 RNF150
 ring finger protein 150
 28603
 0.25
chr10_28287180_28287375 0.17 ARMC4
 armadillo repeat containing 4
 700
 0.81
chr20_31063509_31063841 0.17 C20orf112
 chromosome 20 open reading frame 112
 7599
 0.19
chr2_149894818_149895436 0.17 LYPD6B
 LY6/PLAUR domain containing 6B
 105
 0.98
chr3_122478078_122478289 0.17 ENSG00000238480
 .
 8964
 0.19
chr2_176931780_176932252 0.17 EVX2
 even-skipped homeobox 2
 16625
 0.1
chr10_113595251_113595472 0.17 GPAM
 glycerol-3-phosphate acyltransferase, mitochondrial
 348107
 0.01
chr15_56206351_56206878 0.17 NEDD4
 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
 1238
 0.55
chr3_159484310_159484461 0.16 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 1493
 0.34
chr2_133104359_133104833 0.16 ENSG00000252705
 .
 59835
 0.11
chr7_94034050_94034201 0.16 COL1A2
 collagen, type I, alpha 2
 10252
 0.27
chr18_11983196_11983347 0.16 IMPA2
 inositol(myo)-1(or 4)-monophosphatase 2
 1602
 0.34
chr2_238490360_238490511 0.16 RAB17
 RAB17, member RAS oncogene family
 4307
 0.16
chr16_50236729_50236952 0.16 ADCY7
 adenylate cyclase 7
 43208
 0.12
chr3_65582462_65582613 0.16 MAGI1
 membrane associated guanylate kinase, WW and PDZ domain containing 1
 873
 0.76
chr2_145266428_145266579 0.16 ZEB2
 zinc finger E-box binding homeobox 2
 8612
 0.25
chr15_83620716_83621316 0.16 HOMER2
 homer homolog 2 (Drosophila)
 457
 0.76
chr3_75690482_75691208 0.16 ENSG00000221795
 .
 10931
 0.2
chr1_90158313_90158464 0.16 LRRC8C
 leucine rich repeat containing 8 family, member C
 59757
 0.1
chr22_50698815_50699396 0.16 MAPK12
 mitogen-activated protein kinase 12
 632
 0.49
chr1_205605987_205606138 0.16 ELK4
 ELK4, ETS-domain protein (SRF accessory protein 1)
 4972
 0.18
chr12_12111873_12112098 0.16 ETV6
 ets variant 6
 73114
 0.11
chr3_189794073_189794333 0.15 ENSG00000265045
 .
 37520
 0.14
chr2_175830663_175830896 0.15 ENSG00000201425
 .
 11752
 0.19
chrX_11446077_11446283 0.15 ARHGAP6
 Rho GTPase activating protein 6
 287
 0.95
chr15_38693567_38693718 0.15 FAM98B
 family with sequence similarity 98, member B
 52686
 0.15
chr1_225839301_225840394 0.15 ENAH
 enabled homolog (Drosophila)
 571
 0.78
chrX_106045541_106045714 0.15 TBC1D8B
 TBC1 domain family, member 8B (with GRAM domain)
 283
 0.94
chr10_121209563_121209788 0.15 GRK5
 G protein-coupled receptor kinase 5
 71726
 0.09
chr7_19155354_19155672 0.15 TWIST1
 twist family bHLH transcription factor 1
 1782
 0.28
chr4_166252557_166253372 0.15 MSMO1
 methylsterol monooxygenase 1
 3885
 0.25
chr15_64231749_64232239 0.15 RP11-111E14.1
11521
 0.22
chr1_39284364_39284540 0.14 RRAGC
 Ras-related GTP binding C
 41043
 0.12
chr16_87096172_87096484 0.14 RP11-899L11.3
153193
 0.04
chr11_93582978_93583471 0.14 VSTM5
 V-set and transmembrane domain containing 5
 473
 0.74
chr18_46581903_46582348 0.14 ENSG00000263849
 .
 5987
 0.21
chr1_94158748_94158940 0.14 BCAR3
 breast cancer anti-estrogen resistance 3
 11459
 0.24
chr20_49307514_49308405 0.14 FAM65C
 family with sequence similarity 65, member C
 43
 0.97
chr3_149094469_149095370 0.14 TM4SF1-AS1
 TM4SF1 antisense RNA 1
 646
 0.47
chr14_59331604_59331755 0.14 ENSG00000221427
 .
 93715
 0.09
chr18_65983753_65984295 0.14 TMX3
 thioredoxin-related transmembrane protein 3
 398270
 0.01
chr2_85361754_85362037 0.14 TCF7L1
 transcription factor 7-like 1 (T-cell specific, HMG-box)
 1362
 0.47
chr7_50859466_50860386 0.14 GRB10
 growth factor receptor-bound protein 10
 740
 0.77
chr18_60052258_60052436 0.14 RP11-640A1.3
6984
 0.22
chr5_158488269_158488591 0.14 EBF1
 early B-cell factor 1
 38271
 0.17
chr16_14458625_14458905 0.14 ENSG00000199130
 .
 55623
 0.12
chr10_3828809_3828960 0.14 KLF6
 Kruppel-like factor 6
 1411
 0.47
chr1_203247491_203247930 0.14 BTG2
 BTG family, member 2
 26954
 0.14
chr6_164404752_164405006 0.14 ENSG00000266128
 .
 143286
 0.05
chr10_115860454_115861476 0.14 ENSG00000253066
 .
 10208
 0.2
chr3_170806844_170806995 0.14 ENSG00000207963
 .
 17629
 0.23
chr1_119543090_119543475 0.14 TBX15
 T-box 15
 11103
 0.25
chr16_87250830_87251124 0.13 RP11-899L11.3
1456
 0.45
chr8_23398759_23399053 0.13 SLC25A37
 solute carrier family 25 (mitochondrial iron transporter), member 37
 12333
 0.16
chr15_96899977_96900177 0.13 AC087477.1
 Uncharacterized protein
 4410
 0.2
chr22_47330549_47330700 0.13 ENSG00000221672
 .
 86821
 0.1
chr14_50413720_50413871 0.13 ENSG00000251929
 .
 45127
 0.1
chr12_30353916_30354159 0.13 ENSG00000251781
 .
 105420
 0.08
chr12_113859774_113860410 0.13 SDSL
 serine dehydratase-like
 50
 0.97
chr14_102604980_102605131 0.13 HSP90AA1
 heat shock protein 90kDa alpha (cytosolic), class A member 1
 968
 0.41
chr18_52626293_52626952 0.13 CCDC68
 coiled-coil domain containing 68
 117
 0.97
chr16_3341320_3341471 0.13 ZNF263
 zinc finger protein 263
 992
 0.37
chr4_184492781_184492932 0.13 ENSG00000239116
 .
 10598
 0.19
chr6_32489639_32489790 0.13 HLA-DRB5
 major histocompatibility complex, class II, DR beta 5
 8350
 0.15
chr7_87936252_87936498 0.13 STEAP4
 STEAP family member 4
 169
 0.96
chr5_132112834_132113698 0.13 SEPT8
 septin 8
 153
 0.93
chr4_8594931_8595082 0.13 CPZ
 carboxypeptidase Z
 523
 0.82
chr10_103330110_103330718 0.13 DPCD
 deleted in primary ciliary dyskinesia homolog (mouse)
 8
 0.98
chr12_88973452_88974158 0.13 KITLG
 KIT ligand
 433
 0.82
chr11_89113858_89114276 0.13 NOX4
 NADPH oxidase 4
 109833
 0.07
chr8_125827427_125827626 0.13 ENSG00000263735
 .
 6774
 0.28
chr8_99304651_99304929 0.13 NIPAL2
 NIPA-like domain containing 2
 1774
 0.45
chr3_128268180_128268331 0.13 C3orf27
 chromosome 3 open reading frame 27
 26674
 0.16
chr10_29980674_29981313 0.13 ENSG00000222092
 .
 19851
 0.22
chr3_71294181_71294421 0.13 FOXP1
 forkhead box P1
 15
 0.99
chr17_16159063_16159236 0.13 ENSG00000221355
 .
 26179
 0.13
chr4_55098050_55098472 0.13 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
 1772
 0.47
chr19_30941172_30941421 0.13 ZNF536
 zinc finger protein 536
 77977
 0.12
chr15_75018290_75019298 0.13 CYP1A1
 cytochrome P450, family 1, subfamily A, polypeptide 1
 843
 0.52
chr17_13444026_13444182 0.13 ENSG00000221698
 .
 2859
 0.3
chr16_59669437_59669588 0.13 ENSG00000200062
 .
 95482
 0.09
chr13_27557206_27557734 0.13 USP12-AS1
 USP12 antisense RNA 1
 179522
 0.03
chr22_48594670_48594821 0.13 ENSG00000266508
 .
 75431
 0.13
chr11_61448104_61448359 0.12 DAGLA
 diacylglycerol lipase, alpha
 326
 0.89
chr8_42358295_42358694 0.12 SLC20A2
 solute carrier family 20 (phosphate transporter), member 2
 267
 0.92
chr7_27143412_27143563 0.12 HOXA2
 homeobox A2
 1057
 0.27
chr5_151065704_151066114 0.12 SPARC
 secreted protein, acidic, cysteine-rich (osteonectin)
 615
 0.66
chr21_17567832_17567983 0.12 ENSG00000201025
 .
 89182
 0.1
chr10_101754409_101754592 0.12 DNMBP
 dynamin binding protein
 15176
 0.18
chr2_173037089_173037327 0.12 ENSG00000238572
 .
 16360
 0.23
chr5_52105955_52106201 0.12 CTD-2288O8.1
22218
 0.18
chr1_1934983_1935264 0.12 C1orf222
 chromosome 1 open reading frame 222
 30
 0.96
chr22_45403768_45404420 0.12 PHF21B
 PHD finger protein 21B
 736
 0.7
chr17_32582009_32582182 0.12 CCL2
 chemokine (C-C motif) ligand 2
 209
 0.48
chr15_67840467_67840618 0.12 MAP2K5
 mitogen-activated protein kinase kinase 5
 794
 0.7
chr18_43304377_43304558 0.12 SLC14A1
 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
 318
 0.9
chr14_33104283_33104434 0.12 AKAP6
 A kinase (PRKA) anchor protein 6
 100699
 0.08
chr6_152084748_152085135 0.12 ESR1
 estrogen receptor 1
 40625
 0.17
chr1_185825882_185826255 0.12 HMCN1
 hemicentin 1
 122385
 0.06
chr9_93823154_93823334 0.12 SYK
 spleen tyrosine kinase
 233474
 0.02
chr5_179757668_179757864 0.12 GFPT2
 glutamine-fructose-6-phosphate transaminase 2
 882
 0.61
chr12_15781229_15781461 0.12 EPS8
 epidermal growth factor receptor pathway substrate 8
 33863
 0.17
chr6_132722750_132722944 0.12 MOXD1
 monooxygenase, DBH-like 1
 163
 0.97
chr1_94219763_94219914 0.12 RP11-488P3.1
21162
 0.21
chr3_167580405_167580688 0.12 SERPINI1
 serpin peptidase inhibitor, clade I (neuroserpin), member 1
 55520
 0.16
chr1_234669487_234669677 0.12 TARBP1
 TAR (HIV-1) RNA binding protein 1
 54733
 0.11
chr1_85557311_85557759 0.12 WDR63
 WD repeat domain 63
 29525
 0.15
chr16_55513844_55514378 0.12 MMP2
 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
 201
 0.95
chr1_210412971_210413268 0.12 SERTAD4-AS1
 SERTAD4 antisense RNA 1
 5727
 0.24
chr21_38580312_38580506 0.12 ENSG00000263969
 .
 7497
 0.16
chr13_30983970_30984184 0.12 HMGB1
 high mobility group box 1
 54307
 0.15
chr4_88894663_88894869 0.12 SPP1
 secreted phosphoprotein 1
 2053
 0.33
chr17_77015960_77016131 0.12 C1QTNF1
 C1q and tumor necrosis factor related protein 1
 2851
 0.19
chr11_105482279_105482430 0.12 GRIA4
 glutamate receptor, ionotropic, AMPA 4
 629
 0.84
chr4_138449879_138450179 0.12 PCDH18
 protocadherin 18
 3536
 0.4
chr7_130594902_130595108 0.12 ENSG00000226380
 .
 32707
 0.2
chr10_97723067_97723218 0.12 CC2D2B
 coiled-coil and C2 domain containing 2B
 10644
 0.17
chr2_238321930_238322164 0.12 COL6A3
 collagen, type VI, alpha 3
 744
 0.69
chr3_157156592_157156743 0.12 PTX3
 pentraxin 3, long
 2089
 0.41
chr12_90484641_90484914 0.12 ENSG00000252823
 .
 336941
 0.01
chr6_86162562_86162713 0.12 NT5E
 5'-nucleotidase, ecto (CD73)
 2810
 0.37
chr7_152403601_152404275 0.12 XRCC2
 X-ray repair complementing defective repair in Chinese hamster cells 2
 30688
 0.14
chr1_149287790_149287941 0.12 ENSG00000252105
 .
 1543
 0.36
chr8_75897244_75897545 0.12 CRISPLD1
 cysteine-rich secretory protein LCCL domain containing 1
 531
 0.84
chr11_65790225_65790471 0.12 CATSPER1
 cation channel, sperm associated 1
 3640
 0.11
chr6_113700515_113700666 0.12 ENSG00000222677
 .
 135599
 0.05
chr12_50608832_50609096 0.12 RP3-405J10.4
4423
 0.14
chr2_107501882_107502033 0.12 ST6GAL2
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
 512
 0.85
chr1_234792376_234792776 0.12 IRF2BP2
 interferon regulatory factor 2 binding protein 2
 47305
 0.14
chr4_88480802_88480953 0.12 SPARCL1
 SPARC-like 1 (hevin)
 28664
 0.17
chr14_88596087_88596243 0.11 RP11-300J18.2
114210
 0.06
chr14_78073975_78074126 0.11 SPTLC2
 serine palmitoyltransferase, long chain base subunit 2
 9066
 0.2
chr2_151342010_151342200 0.11 RND3
 Rho family GTPase 3
 209
 0.97
chr5_53830476_53830627 0.11 SNX18
 sorting nexin 18
 16958
 0.27
chr12_16039681_16039832 0.11 STRAP
 serine/threonine kinase receptor associated protein
 4427
 0.23
chr3_114341689_114341840 0.11 ZBTB20
 zinc finger and BTB domain containing 20
 1289
 0.61
chr10_30138566_30138997 0.11 SVIL
 supervillin
 114048
 0.06
chr2_205587293_205587444 0.11 PARD3B
 par-3 family cell polarity regulator beta
 176645
 0.04
chr5_22853202_22853504 0.11 CDH12
 cadherin 12, type 2 (N-cadherin 2)
 97
 0.99

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT1_STAT3_BCL6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.1 0.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 0.2 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.3 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.1 0.2 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.3 GO:0090103 cochlea morphogenesis(GO:0090103)
0.0 0.1 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 0.3 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.2 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0 0.2 GO:0036296 response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0 0.1 GO:0030812 negative regulation of nucleotide catabolic process(GO:0030812)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.0 GO:0001743 optic placode formation(GO:0001743)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.1 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.2 GO:0008347 glial cell migration(GO:0008347)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.0 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0044803 multi-organism membrane organization(GO:0044803)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.1 GO:0002076 osteoblast development(GO:0002076)
0.0 0.0 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0085029 extracellular matrix assembly(GO:0085029)
0.0 0.1 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.0 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.0 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.0 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.0 GO:0061004 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.0 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.0 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.0 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0048488 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.0 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
0.0 0.0 GO:1901538 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.0 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.0 GO:0033084 immature T cell proliferation in thymus(GO:0033080) regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.0 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.0 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.0 GO:0060677 ureteric bud elongation(GO:0060677)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0031105 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.3 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.0 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.3 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.0 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.0 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.1 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.1 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.0 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.0 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 0.1 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters