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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for STAT5B

Z-value: 0.61

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Transcription factors associated with STAT5B

Gene Symbol	Gene ID	Gene Info
STAT5B Ensembl NCBI GeneCards UniProt	ENSG00000173757.5	STAT5B

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
STAT5B	chr17_40429185_40429364	549	0.641731	-0.43	2.5e-01	Click!
STAT5B	chr17_40426926_40427118	1402	0.266467	-0.43	2.5e-01	Click!
STAT5B	chr17_40427243_40427997	804	0.471429	-0.31	4.2e-01	Click!
STAT5B	chr17_40428589_40429042	90	0.946452	-0.27	4.9e-01	Click!
STAT5B	chr17_40428204_40428355	145	0.924914	-0.11	7.7e-01	Click!

Activity of the STAT5B motif across conditions

Conditions sorted by the z-value of the STAT5B motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_138449879_138450179	0.55	PCDH18	protocadherin 18	3536	0.4
chr19_44860491_44860902	0.29	ZNF112	zinc finger protein 112	130	0.96
chr12_56138916_56139328	0.29	GDF11	growth differentiation factor 11	1939	0.16
chr10_126843486_126843769	0.28	CTBP2	C-terminal binding protein 2	3658	0.35
chr17_59478534_59478762	0.27	RP11-332H18.5		1044	0.31
chr9_115774055_115774548	0.27	ZFP37	ZFP37 zinc finger protein	44667	0.16
chr7_112725821_112726406	0.27	GPR85	G protein-coupled receptor 85	280	0.92
chr19_55684291_55685412	0.27	SYT5	synaptotagmin V	1083	0.28
chr6_27515697_27516098	0.26	ENSG00000206671	.	48294	0.13
chr5_38846105_38846894	0.26	OSMR	oncostatin M receptor	398	0.91
chr19_55677599_55678034	0.26	DNAAF3	dynein, axonemal, assembly factor 3	104	0.87
chr1_172110530_172111247	0.26	ENSG00000207949	.	2841	0.22
chr2_133061942_133062584	0.26	ENSG00000221288	.	47610	0.14
chr10_22894404_22894761	0.26	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	13940	0.29
chr3_129407054_129407730	0.25	TMCC1	transmembrane and coiled-coil domain family 1	183	0.96
chr15_63337269_63337696	0.25	TPM1	tropomyosin 1 (alpha)	1507	0.37
chr8_105373378_105373573	0.25	DCSTAMP	dendrocyte expressed seven transmembrane protein	12706	0.2
chr13_27557206_27557734	0.24	USP12-AS1	USP12 antisense RNA 1	179522	0.03
chr3_123602332_123603013	0.24	MYLK	myosin light chain kinase	477	0.85
chr19_46916092_46916684	0.24	CCDC8	coiled-coil domain containing 8	453	0.75
chr17_12568379_12568897	0.23	MYOCD	myocardin	668	0.75
chr4_160219678_160219941	0.23	ENSG00000216089	.	2943	0.31
chr15_44093610_44093878	0.23	HYPK	huntingtin interacting protein K	947	0.25
chrX_67913478_67914353	0.23	STARD8	StAR-related lipid transfer (START) domain containing 8	422	0.91
chr7_152403601_152404275	0.23	XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	30688	0.14
chr11_8854095_8854571	0.23	ST5	suppression of tumorigenicity 5	847	0.53
chr11_57530814_57530965	0.23	CTNND1	catenin (cadherin-associated protein), delta 1	436	0.77
chr9_97662711_97663102	0.22	RP11-49O14.2		195	0.95
chr2_223163063_223163341	0.22	PAX3	paired box 3	263	0.57
chr10_89802413_89802899	0.22	ENSG00000200891	.	48204	0.17
chr7_47576453_47576928	0.22	TNS3	tensin 3	2185	0.45
chr8_127846488_127846716	0.22	ENSG00000212451	.	162835	0.04
chr1_95330057_95330663	0.22	SLC44A3	solute carrier family 44, member 3	2527	0.28
chr4_118005872_118006140	0.22	TRAM1L1	translocation associated membrane protein 1-like 1	730	0.82
chr8_68304896_68305241	0.22	ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	49156	0.18
chr7_132299406_132299928	0.21	PLXNA4	plexin A4	33780	0.18
chr6_163840513_163841070	0.21	QKI	QKI, KH domain containing, RNA binding	3375	0.39
chr9_19493377_19493724	0.21	RP11-363E7.4		40343	0.16
chr2_151336714_151337073	0.21	RND3	Rho family GTPase 3	5003	0.36
chr4_54063057_54063462	0.21	ENSG00000207385	.	68475	0.13
chr10_36461738_36461970	0.21	ENSG00000237002	.	265735	0.02
chr3_45096456_45096713	0.20	ENSG00000252410	.	20504	0.16
chr7_100765722_100766153	0.20	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	4433	0.12
chr15_33009221_33009412	0.20	GREM1	gremlin 1, DAN family BMP antagonist	859	0.63
chr13_114147905_114148103	0.20	TMCO3	transmembrane and coiled-coil domains 3	2646	0.19
chr7_143581670_143581927	0.20	FAM115A	family with sequence similarity 115, member A	665	0.7
chr5_7396416_7397106	0.20	ADCY2	adenylate cyclase 2 (brain)	440	0.88
chr2_159992813_159993143	0.20	ENSG00000202029	.	109324	0.06
chr6_129203821_129204789	0.20	LAMA2	laminin, alpha 2	37	0.99
chr3_167812396_167812591	0.20	GOLIM4	golgi integral membrane protein 4	639	0.83
chr12_10902635_10902853	0.20	YBX3	Y box binding protein 3	26833	0.13
chr15_37175433_37176047	0.20	ENSG00000212511	.	30899	0.23
chr13_73438368_73438629	0.20	ENSG00000220981	.	13272	0.19
chr3_61649650_61649813	0.19	ENSG00000252420	.	75172	0.12
chr5_82768204_82768925	0.19	VCAN	versican	820	0.75
chr12_15941079_15941239	0.19	EPS8	epidermal growth factor receptor pathway substrate 8	1156	0.62
chr1_54197803_54198068	0.19	GLIS1	GLIS family zinc finger 1	1942	0.34
chr9_21764802_21765039	0.19	MTAP	methylthioadenosine phosphorylase	37622	0.15
chr7_155006728_155006879	0.19	AC099552.4	Uncharacterized protein	16657	0.2
chr11_79149678_79149969	0.19	TENM4	teneurin transmembrane protein 4	1872	0.38
chr3_149094469_149095370	0.19	TM4SF1-AS1	TM4SF1 antisense RNA 1	646	0.47
chr2_142888867_142889088	0.18	LRP1B	low density lipoprotein receptor-related protein 1B	293	0.93
chr11_123062062_123062213	0.18	CTD-2216M2.1		2627	0.27
chr2_145266428_145266579	0.18	ZEB2	zinc finger E-box binding homeobox 2	8612	0.25
chr20_23224910_23225093	0.18	ENSG00000201527	.	83393	0.07
chr15_42749459_42749764	0.18	ZNF106	zinc finger protein 106	100	0.96
chr10_17034557_17035249	0.18	CUBN	cubilin (intrinsic factor-cobalamin receptor)	8709	0.3
chr7_77650153_77650326	0.18	RP5-1185I7.1		30502	0.24
chr1_221509112_221509492	0.17	DUSP10	dual specificity phosphatase 10	401500	0.01
chr8_136471145_136471318	0.17	KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3	281	0.92
chr1_77737435_77737712	0.17	AK5	adenylate kinase 5	10163	0.23
chr11_89113858_89114276	0.17	NOX4	NADPH oxidase 4	109833	0.07
chr12_29935925_29936182	0.17	TMTC1	transmembrane and tetratricopeptide repeat containing 1	678	0.82
chr11_122311553_122311819	0.17	ENSG00000252776	.	8232	0.23
chr3_137833372_137833843	0.17	DZIP1L	DAZ interacting zinc finger protein 1-like	844	0.63
chr20_14317720_14318261	0.17	FLRT3	fibronectin leucine rich transmembrane protein 3	264	0.94
chr5_43308499_43308850	0.17	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	4652	0.23
chr2_190477763_190477914	0.17	SLC40A1	solute carrier family 40 (iron-regulated transporter), member 1	29354	0.16
chrX_106045541_106045714	0.17	TBC1D8B	TBC1 domain family, member 8B (with GRAM domain)	283	0.94
chr1_87793556_87794116	0.17	LMO4	LIM domain only 4	315	0.94
chr17_46672091_46672242	0.17	HOXB5	homeobox B5	843	0.28
chr6_113700515_113700666	0.17	ENSG00000222677	.	135599	0.05
chr20_17643261_17643428	0.17	RRBP1	ribosome binding protein 1	2192	0.33
chr5_89317325_89317513	0.17	ENSG00000264342	.	4882	0.36
chr11_114167823_114168031	0.17	NNMT	nicotinamide N-methyltransferase	158	0.96
chr1_196620715_196621368	0.17	CFH	complement factor H	33	0.98
chr5_123493061_123493232	0.16	CSNK1G3	casein kinase 1, gamma 3	569027	0.0
chr8_104384541_104384884	0.16	CTHRC1	collagen triple helix repeat containing 1	51	0.97
chr3_161883288_161883607	0.16	OTOL1	otolin 1	668851	0.0
chr6_27205685_27206711	0.16	PRSS16	protease, serine, 16 (thymus)	9282	0.19
chr3_33397150_33397316	0.16	ENSG00000252700	.	58409	0.12
chr2_158752022_158752173	0.16	ENSG00000251980	.	17187	0.16
chr5_83140533_83140765	0.16	ENSG00000202157	.	41276	0.19
chr18_60052258_60052436	0.16	RP11-640A1.3		6984	0.22
chr16_18811323_18811474	0.16	ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	1348	0.27
chr19_58400508_58400670	0.16	ZNF814	zinc finger protein 814	184	0.9
chr2_151340168_151340387	0.16	RND3	Rho family GTPase 3	1619	0.57
chr5_122620941_122621184	0.16	CEP120	centrosomal protein 120kDa	137935	0.04
chr7_38624277_38624485	0.16	AMPH	amphiphysin	46639	0.16
chr5_119874213_119874384	0.15	PRR16	proline rich 16	7139	0.33
chr8_17106304_17106459	0.15	VPS37A	vacuolar protein sorting 37 homolog A (S. cerevisiae)	1628	0.35
chr6_16675168_16675421	0.15	RP1-151F17.1		86075	0.1
chr6_27173563_27173801	0.15	PRSS16	protease, serine, 16 (thymus)	41798	0.1
chr8_94238484_94238635	0.15	AC016885.1	Uncharacterized protein	3308	0.29
chr19_39919352_39919568	0.15	PLEKHG2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	4049	0.09
chr2_145212550_145212714	0.15	ZEB2	zinc finger E-box binding homeobox 2	24495	0.24
chr2_37116896_37117561	0.15	ENSG00000252756	.	22590	0.18
chr1_231543825_231544251	0.15	EGLN1	egl-9 family hypoxia-inducible factor 1	16752	0.2
chr2_232492715_232492900	0.15	ENSG00000239202	.	18177	0.16
chr8_54793517_54794385	0.15	RGS20	regulator of G-protein signaling 20	497	0.79
chr10_5491792_5492244	0.15	NET1	neuroepithelial cell transforming 1	3444	0.22
chr1_236827439_236827590	0.15	ACTN2	actinin, alpha 2	22240	0.21
chr1_201916514_201916665	0.15	LMOD1	leiomodin 1 (smooth muscle)	874	0.44
chr13_80707939_80708090	0.15	SPRY2	sprouty homolog 2 (Drosophila)	205780	0.03
chr6_27584810_27585278	0.15	ENSG00000238648	.	14144	0.19
chr8_77867156_77867509	0.15	ENSG00000266712	.	11754	0.26
chr15_96886136_96886425	0.15	ENSG00000222651	.	9790	0.16
chrX_28604967_28605213	0.15	IL1RAPL1	interleukin 1 receptor accessory protein-like 1	426	0.92
chr1_32268041_32268276	0.15	SPOCD1	SPOC domain containing 1	3718	0.19
chr16_74204020_74204218	0.15	PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	126554	0.05
chr3_197099341_197099661	0.15	ENSG00000238491	.	33079	0.17
chr17_739288_739623	0.15	NXN	nucleoredoxin	10214	0.15
chr8_125827427_125827626	0.15	ENSG00000263735	.	6774	0.28
chr20_49307514_49308405	0.15	FAM65C	family with sequence similarity 65, member C	43	0.97
chr6_139656188_139656543	0.15	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	38985	0.15
chr10_19026614_19026765	0.15	ARL5B	ADP-ribosylation factor-like 5B	78355	0.1
chr6_27255999_27256495	0.15	POM121L2	POM121 transmembrane nucleoporin-like 2	22844	0.18
chr8_108342593_108342744	0.15	ANGPT1	angiopoietin 1	6082	0.32
chr12_105065797_105066143	0.15	ENSG00000264295	.	80559	0.1
chr6_116832868_116833176	0.15	FAM26E	family with sequence similarity 26, member E	213	0.73
chr3_75690482_75691208	0.14	ENSG00000221795	.	10931	0.2
chr2_60808641_60809007	0.14	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	28122	0.19
chr11_122513572_122513810	0.14	UBASH3B	ubiquitin associated and SH3 domain containing B	12692	0.24
chr9_123698545_123698822	0.14	TRAF1	TNF receptor-associated factor 1	7232	0.23
chr15_39871853_39872515	0.14	THBS1	thrombospondin 1	1096	0.52
chrX_99904753_99905093	0.14	SRPX2	sushi-repeat containing protein, X-linked 2	5708	0.19
chr5_167696137_167696498	0.14	WWC1	WW and C2 domain containing 1	22339	0.2
chr1_8587025_8587260	0.14	RERE	arginine-glutamic acid dipeptide (RE) repeats	1056	0.58
chr10_13748985_13749251	0.14	ENSG00000222235	.	2140	0.21
chr2_47499719_47500092	0.14	EPCAM	epithelial cell adhesion molecule	72392	0.09
chr4_142003365_142003602	0.14	RNF150	ring finger protein 150	28603	0.25
chr9_75653628_75653779	0.14	ALDH1A1	aldehyde dehydrogenase 1 family, member A1	65	0.99
chr15_98504600_98505000	0.14	ARRDC4	arrestin domain containing 4	872	0.68
chr9_110250307_110251795	0.14	KLF4	Kruppel-like factor 4 (gut)	360	0.89
chr20_31063509_31063841	0.14	C20orf112	chromosome 20 open reading frame 112	7599	0.19
chr5_54864628_54864779	0.14	PPAP2A	phosphatidic acid phosphatase type 2A	33825	0.18
chr10_14032873_14033043	0.14	RP11-142M10.2		857	0.66
chr3_55519561_55519953	0.14	WNT5A	wingless-type MMTV integration site family, member 5A	1574	0.4
chr19_44598113_44598899	0.14	ZNF224	zinc finger protein 224	14	0.94
chr10_4284967_4285185	0.14	ENSG00000207124	.	272068	0.02
chr5_54457024_54457471	0.14	GPX8	glutathione peroxidase 8 (putative)	1249	0.31
chr12_116796712_116796969	0.14	ENSG00000264037	.	69283	0.11
chr2_223912434_223912604	0.14	KCNE4	potassium voltage-gated channel, Isk-related family, member 4	4013	0.33
chr10_65479976_65480138	0.14	REEP3	receptor accessory protein 3	198934	0.03
chr1_59478905_59479109	0.14	JUN	jun proto-oncogene	229222	0.02
chr1_224805949_224806359	0.14	CNIH3	cornichon family AMPA receptor auxiliary protein 3	2159	0.29
chr8_101555325_101555476	0.14	ANKRD46	ankyrin repeat domain 46	9847	0.18
chr7_28944342_28944522	0.14	CTB-113D17.1		75151	0.1
chr6_81257814_81258158	0.14	BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	441603	0.01
chr21_17497269_17497520	0.14	ENSG00000252273	.	89565	0.1
chr20_10720180_10720390	0.14	JAG1	jagged 1	65591	0.13
chr3_73119964_73120214	0.13	PPP4R2	protein phosphatase 4, regulatory subunit 2	6924	0.14
chr18_46451248_46451445	0.13	SMAD7	SMAD family member 7	23529	0.22
chr14_27244705_27244856	0.13	NOVA1-AS1	NOVA1 antisense RNA 1 (head to head)	6594	0.31
chr3_177002301_177002503	0.13	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	87141	0.1
chr10_113595251_113595472	0.13	GPAM	glycerol-3-phosphate acyltransferase, mitochondrial	348107	0.01
chr14_52518827_52518978	0.13	NID2	nidogen 2 (osteonidogen)	13232	0.2
chr3_147140468_147140953	0.13	ZIC1	Zic family member 1	13539	0.19
chr19_46920028_46920207	0.13	CCDC8	coiled-coil domain containing 8	3276	0.17
chrX_41449282_41449446	0.13	CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	160	0.95
chr2_199364486_199364637	0.13	ENSG00000252511	.	66892	0.15
chr13_34083543_34083799	0.13	STARD13	StAR-related lipid transfer (START) domain containing 13	158904	0.04
chr3_120216529_120216680	0.13	FSTL1	follistatin-like 1	46504	0.16
chr4_140807822_140807973	0.13	MAML3	mastermind-like 3 (Drosophila)	3309	0.35
chr9_110310779_110311295	0.13	KLF4	Kruppel-like factor 4 (gut)	58274	0.13
chr17_41622177_41622554	0.13	RP11-392O1.4		212	0.81
chr11_65666484_65666730	0.13	FOSL1	FOS-like antigen 1	1283	0.23
chr13_75466427_75466770	0.13	ENSG00000206812	.	217126	0.02
chr2_173037089_173037327	0.13	ENSG00000238572	.	16360	0.23
chr1_231002889_231003524	0.13	C1orf198	chromosome 1 open reading frame 198	1193	0.37
chr4_120613511_120613662	0.13	PDE5A	phosphodiesterase 5A, cGMP-specific	63440	0.14
chr12_5542106_5542552	0.13	NTF3	neurotrophin 3	1050	0.7
chr12_12111873_12112098	0.13	ETV6	ets variant 6	73114	0.11
chr2_181388274_181388425	0.13	ENSG00000264976	.	93584	0.1
chr4_187491209_187491867	0.13	MTNR1A	melatonin receptor 1A	14817	0.17
chr5_65265501_65265702	0.13	ENSG00000252904	.	8454	0.24
chr1_92330105_92330395	0.13	TGFBR3	transforming growth factor, beta receptor III	3100	0.29
chr1_1207989_1209115	0.13	UBE2J2	ubiquitin-conjugating enzyme E2, J2	299	0.76
chr17_79361759_79361910	0.13	RP11-1055B8.6	Uncharacterized protein	7441	0.12
chr1_1934983_1935264	0.13	C1orf222	chromosome 1 open reading frame 222	30	0.96
chr18_7460286_7460529	0.13	PTPRM	protein tyrosine phosphatase, receptor type, M	106373	0.07
chr19_45720617_45720890	0.13	EXOC3L2	exocyst complex component 3-like 2	14385	0.11
chr11_116857809_116858077	0.13	ENSG00000264344	.	28302	0.13
chr3_117419873_117420024	0.13	ENSG00000206889	.	156896	0.04
chr5_179758220_179758506	0.13	GFPT2	glutamine-fructose-6-phosphate transaminase 2	285	0.91
chr12_66222800_66222951	0.13	HMGA2	high mobility group AT-hook 2	3972	0.25
chr6_152450893_152451044	0.13	SYNE1	spectrin repeat containing, nuclear envelope 1	38518	0.22
chr9_111206714_111207024	0.13	ENSG00000222512	.	85660	0.11
chr6_74406883_74407034	0.13	RP11-553A21.3		1104	0.37
chr3_130236746_130236897	0.13	COL6A6	collagen, type VI, alpha 6	42357	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5B

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.1	0.2	GO:0032224	positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1	0.2	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.1	0.2	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.2	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.0	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.1	GO:0031223	response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.2	GO:0090177	establishment of planar polarity involved in neural tube closure(GO:0090177)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.1	GO:0002024	diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.0	0.1	GO:2000188	regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0051927	obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0046021	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.1	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.2	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.2	GO:0001738	morphogenesis of a polarized epithelium(GO:0001738)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.2	GO:0035329	hippo signaling(GO:0035329)
0.0	0.0	GO:0033087	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.2	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.1	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.0	GO:0072071	mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.0	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:2001280	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0010544	negative regulation of platelet activation(GO:0010544)
0.0	0.2	GO:0002675	positive regulation of acute inflammatory response(GO:0002675)
0.0	0.1	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.1	GO:0061726	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0046618	drug export(GO:0046618)
0.0	0.0	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0021781	glial cell fate commitment(GO:0021781)
0.0	0.0	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.0	GO:0014824	tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0	0.0	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:0008347	glial cell migration(GO:0008347)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.0	GO:0060027	convergent extension involved in gastrulation(GO:0060027)
0.0	0.1	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.0	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0	0.0	GO:0046512	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.0	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.0	GO:0042670	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.0	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.3	GO:0001843	neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.2	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.4	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.2	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.0	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0043205	fibril(GO:0043205)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.2	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.2	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.2	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.2	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.2	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.0	GO:0030172	troponin C binding(GO:0030172)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.2	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.2	GO:0005109	frizzled binding(GO:0005109)
0.0	0.0	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.0	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.0	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.0	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.0	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	ST ADRENERGIC	Adrenergic Pathway
0.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.3	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.4	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.0	0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.0	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction