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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for STAT5B

Z-value: 0.61

Motif logo

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Transcription factors associated with STAT5B

Gene Symbol Gene ID Gene Info
STAT5B
ENSG00000173757.5 signal transducer and activator of transcription 5B

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr17_40429185_40429364STAT5B5490.641731-0.432.5e-01Click!
chr17_40426926_40427118STAT5B14020.266467-0.432.5e-01Click!
chr17_40427243_40427997STAT5B8040.471429-0.314.2e-01Click!
chr17_40428589_40429042STAT5B900.946452-0.274.9e-01Click!
chr17_40428204_40428355STAT5B1450.924914-0.117.7e-01Click!

Activity of the STAT5B motif across conditions

Conditions sorted by the z-value of the STAT5B motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr4_138449879_138450179 0.55 PCDH18
 protocadherin 18
 3536
 0.4
chr19_44860491_44860902 0.29 ZNF112
 zinc finger protein 112
 130
 0.96
chr12_56138916_56139328 0.29 GDF11
 growth differentiation factor 11
 1939
 0.16
chr10_126843486_126843769 0.28 CTBP2
 C-terminal binding protein 2
 3658
 0.35
chr17_59478534_59478762 0.27 RP11-332H18.5
1044
 0.31
chr9_115774055_115774548 0.27 ZFP37
 ZFP37 zinc finger protein
 44667
 0.16
chr7_112725821_112726406 0.27 GPR85
 G protein-coupled receptor 85
 280
 0.92
chr19_55684291_55685412 0.27 SYT5
 synaptotagmin V
 1083
 0.28
chr6_27515697_27516098 0.26 ENSG00000206671
 .
 48294
 0.13
chr5_38846105_38846894 0.26 OSMR
 oncostatin M receptor
 398
 0.91
chr19_55677599_55678034 0.26 DNAAF3
 dynein, axonemal, assembly factor 3
 104
 0.87
chr1_172110530_172111247 0.26 ENSG00000207949
 .
 2841
 0.22
chr2_133061942_133062584 0.26 ENSG00000221288
 .
 47610
 0.14
chr10_22894404_22894761 0.26 PIP4K2A
 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
 13940
 0.29
chr3_129407054_129407730 0.25 TMCC1
 transmembrane and coiled-coil domain family 1
 183
 0.96
chr15_63337269_63337696 0.25 TPM1
 tropomyosin 1 (alpha)
 1507
 0.37
chr8_105373378_105373573 0.25 DCSTAMP
 dendrocyte expressed seven transmembrane protein
 12706
 0.2
chr13_27557206_27557734 0.24 USP12-AS1
 USP12 antisense RNA 1
 179522
 0.03
chr3_123602332_123603013 0.24 MYLK
 myosin light chain kinase
 477
 0.85
chr19_46916092_46916684 0.24 CCDC8
 coiled-coil domain containing 8
 453
 0.75
chr17_12568379_12568897 0.23 MYOCD
 myocardin
 668
 0.75
chr4_160219678_160219941 0.23 ENSG00000216089
 .
 2943
 0.31
chr15_44093610_44093878 0.23 HYPK
 huntingtin interacting protein K
 947
 0.25
chrX_67913478_67914353 0.23 STARD8
 StAR-related lipid transfer (START) domain containing 8
 422
 0.91
chr7_152403601_152404275 0.23 XRCC2
 X-ray repair complementing defective repair in Chinese hamster cells 2
 30688
 0.14
chr11_8854095_8854571 0.23 ST5
 suppression of tumorigenicity 5
 847
 0.53
chr11_57530814_57530965 0.23 CTNND1
 catenin (cadherin-associated protein), delta 1
 436
 0.77
chr9_97662711_97663102 0.22 RP11-49O14.2
195
 0.95
chr2_223163063_223163341 0.22 PAX3
 paired box 3
 263
 0.57
chr10_89802413_89802899 0.22 ENSG00000200891
 .
 48204
 0.17
chr7_47576453_47576928 0.22 TNS3
 tensin 3
 2185
 0.45
chr8_127846488_127846716 0.22 ENSG00000212451
 .
 162835
 0.04
chr1_95330057_95330663 0.22 SLC44A3
 solute carrier family 44, member 3
 2527
 0.28
chr4_118005872_118006140 0.22 TRAM1L1
 translocation associated membrane protein 1-like 1
 730
 0.82
chr8_68304896_68305241 0.22 ARFGEF1
 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
 49156
 0.18
chr7_132299406_132299928 0.21 PLXNA4
 plexin A4
 33780
 0.18
chr6_163840513_163841070 0.21 QKI
 QKI, KH domain containing, RNA binding
 3375
 0.39
chr9_19493377_19493724 0.21 RP11-363E7.4
40343
 0.16
chr2_151336714_151337073 0.21 RND3
 Rho family GTPase 3
 5003
 0.36
chr4_54063057_54063462 0.21 ENSG00000207385
 .
 68475
 0.13
chr10_36461738_36461970 0.21 ENSG00000237002
 .
 265735
 0.02
chr3_45096456_45096713 0.20 ENSG00000252410
 .
 20504
 0.16
chr7_100765722_100766153 0.20 SERPINE1
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 4433
 0.12
chr15_33009221_33009412 0.20 GREM1
 gremlin 1, DAN family BMP antagonist
 859
 0.63
chr13_114147905_114148103 0.20 TMCO3
 transmembrane and coiled-coil domains 3
 2646
 0.19
chr7_143581670_143581927 0.20 FAM115A
 family with sequence similarity 115, member A
 665
 0.7
chr5_7396416_7397106 0.20 ADCY2
 adenylate cyclase 2 (brain)
 440
 0.88
chr2_159992813_159993143 0.20 ENSG00000202029
 .
 109324
 0.06
chr6_129203821_129204789 0.20 LAMA2
 laminin, alpha 2
 37
 0.99
chr3_167812396_167812591 0.20 GOLIM4
 golgi integral membrane protein 4
 639
 0.83
chr12_10902635_10902853 0.20 YBX3
 Y box binding protein 3
 26833
 0.13
chr15_37175433_37176047 0.20 ENSG00000212511
 .
 30899
 0.23
chr13_73438368_73438629 0.20 ENSG00000220981
 .
 13272
 0.19
chr3_61649650_61649813 0.19 ENSG00000252420
 .
 75172
 0.12
chr5_82768204_82768925 0.19 VCAN
 versican
 820
 0.75
chr12_15941079_15941239 0.19 EPS8
 epidermal growth factor receptor pathway substrate 8
 1156
 0.62
chr1_54197803_54198068 0.19 GLIS1
 GLIS family zinc finger 1
 1942
 0.34
chr9_21764802_21765039 0.19 MTAP
 methylthioadenosine phosphorylase
 37622
 0.15
chr7_155006728_155006879 0.19 AC099552.4
 Uncharacterized protein
 16657
 0.2
chr11_79149678_79149969 0.19 TENM4
 teneurin transmembrane protein 4
 1872
 0.38
chr3_149094469_149095370 0.19 TM4SF1-AS1
 TM4SF1 antisense RNA 1
 646
 0.47
chr2_142888867_142889088 0.18 LRP1B
 low density lipoprotein receptor-related protein 1B
 293
 0.93
chr11_123062062_123062213 0.18 CTD-2216M2.1
2627
 0.27
chr2_145266428_145266579 0.18 ZEB2
 zinc finger E-box binding homeobox 2
 8612
 0.25
chr20_23224910_23225093 0.18 ENSG00000201527
 .
 83393
 0.07
chr15_42749459_42749764 0.18 ZNF106
 zinc finger protein 106
 100
 0.96
chr10_17034557_17035249 0.18 CUBN
 cubilin (intrinsic factor-cobalamin receptor)
 8709
 0.3
chr7_77650153_77650326 0.18 RP5-1185I7.1
30502
 0.24
chr1_221509112_221509492 0.17 DUSP10
 dual specificity phosphatase 10
 401500
 0.01
chr8_136471145_136471318 0.17 KHDRBS3
 KH domain containing, RNA binding, signal transduction associated 3
 281
 0.92
chr1_77737435_77737712 0.17 AK5
 adenylate kinase 5
 10163
 0.23
chr11_89113858_89114276 0.17 NOX4
 NADPH oxidase 4
 109833
 0.07
chr12_29935925_29936182 0.17 TMTC1
 transmembrane and tetratricopeptide repeat containing 1
 678
 0.82
chr11_122311553_122311819 0.17 ENSG00000252776
 .
 8232
 0.23
chr3_137833372_137833843 0.17 DZIP1L
 DAZ interacting zinc finger protein 1-like
 844
 0.63
chr20_14317720_14318261 0.17 FLRT3
 fibronectin leucine rich transmembrane protein 3
 264
 0.94
chr5_43308499_43308850 0.17 HMGCS1
 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
 4652
 0.23
chr2_190477763_190477914 0.17 SLC40A1
 solute carrier family 40 (iron-regulated transporter), member 1
 29354
 0.16
chrX_106045541_106045714 0.17 TBC1D8B
 TBC1 domain family, member 8B (with GRAM domain)
 283
 0.94
chr1_87793556_87794116 0.17 LMO4
 LIM domain only 4
 315
 0.94
chr17_46672091_46672242 0.17 HOXB5
 homeobox B5
 843
 0.28
chr6_113700515_113700666 0.17 ENSG00000222677
 .
 135599
 0.05
chr20_17643261_17643428 0.17 RRBP1
 ribosome binding protein 1
 2192
 0.33
chr5_89317325_89317513 0.17 ENSG00000264342
 .
 4882
 0.36
chr11_114167823_114168031 0.17 NNMT
 nicotinamide N-methyltransferase
 158
 0.96
chr1_196620715_196621368 0.17 CFH
 complement factor H
 33
 0.98
chr5_123493061_123493232 0.16 CSNK1G3
 casein kinase 1, gamma 3
 569027
 0.0
chr8_104384541_104384884 0.16 CTHRC1
 collagen triple helix repeat containing 1
 51
 0.97
chr3_161883288_161883607 0.16 OTOL1
 otolin 1
 668851
 0.0
chr6_27205685_27206711 0.16 PRSS16
 protease, serine, 16 (thymus)
 9282
 0.19
chr3_33397150_33397316 0.16 ENSG00000252700
 .
 58409
 0.12
chr2_158752022_158752173 0.16 ENSG00000251980
 .
 17187
 0.16
chr5_83140533_83140765 0.16 ENSG00000202157
 .
 41276
 0.19
chr18_60052258_60052436 0.16 RP11-640A1.3
6984
 0.22
chr16_18811323_18811474 0.16 ARL6IP1
 ADP-ribosylation factor-like 6 interacting protein 1
 1348
 0.27
chr19_58400508_58400670 0.16 ZNF814
 zinc finger protein 814
 184
 0.9
chr2_151340168_151340387 0.16 RND3
 Rho family GTPase 3
 1619
 0.57
chr5_122620941_122621184 0.16 CEP120
 centrosomal protein 120kDa
 137935
 0.04
chr7_38624277_38624485 0.16 AMPH
 amphiphysin
 46639
 0.16
chr5_119874213_119874384 0.15 PRR16
 proline rich 16
 7139
 0.33
chr8_17106304_17106459 0.15 VPS37A
 vacuolar protein sorting 37 homolog A (S. cerevisiae)
 1628
 0.35
chr6_16675168_16675421 0.15 RP1-151F17.1
86075
 0.1
chr6_27173563_27173801 0.15 PRSS16
 protease, serine, 16 (thymus)
 41798
 0.1
chr8_94238484_94238635 0.15 AC016885.1
 Uncharacterized protein
 3308
 0.29
chr19_39919352_39919568 0.15 PLEKHG2
 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
 4049
 0.09
chr2_145212550_145212714 0.15 ZEB2
 zinc finger E-box binding homeobox 2
 24495
 0.24
chr2_37116896_37117561 0.15 ENSG00000252756
 .
 22590
 0.18
chr1_231543825_231544251 0.15 EGLN1
 egl-9 family hypoxia-inducible factor 1
 16752
 0.2
chr2_232492715_232492900 0.15 ENSG00000239202
 .
 18177
 0.16
chr8_54793517_54794385 0.15 RGS20
 regulator of G-protein signaling 20
 497
 0.79
chr10_5491792_5492244 0.15 NET1
 neuroepithelial cell transforming 1
 3444
 0.22
chr1_236827439_236827590 0.15 ACTN2
 actinin, alpha 2
 22240
 0.21
chr1_201916514_201916665 0.15 LMOD1
 leiomodin 1 (smooth muscle)
 874
 0.44
chr13_80707939_80708090 0.15 SPRY2
 sprouty homolog 2 (Drosophila)
 205780
 0.03
chr6_27584810_27585278 0.15 ENSG00000238648
 .
 14144
 0.19
chr8_77867156_77867509 0.15 ENSG00000266712
 .
 11754
 0.26
chr15_96886136_96886425 0.15 ENSG00000222651
 .
 9790
 0.16
chrX_28604967_28605213 0.15 IL1RAPL1
 interleukin 1 receptor accessory protein-like 1
 426
 0.92
chr1_32268041_32268276 0.15 SPOCD1
 SPOC domain containing 1
 3718
 0.19
chr16_74204020_74204218 0.15 PSMD7
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
 126554
 0.05
chr3_197099341_197099661 0.15 ENSG00000238491
 .
 33079
 0.17
chr17_739288_739623 0.15 NXN
 nucleoredoxin
 10214
 0.15
chr8_125827427_125827626 0.15 ENSG00000263735
 .
 6774
 0.28
chr20_49307514_49308405 0.15 FAM65C
 family with sequence similarity 65, member C
 43
 0.97
chr6_139656188_139656543 0.15 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 38985
 0.15
chr10_19026614_19026765 0.15 ARL5B
 ADP-ribosylation factor-like 5B
 78355
 0.1
chr6_27255999_27256495 0.15 POM121L2
 POM121 transmembrane nucleoporin-like 2
 22844
 0.18
chr8_108342593_108342744 0.15 ANGPT1
 angiopoietin 1
 6082
 0.32
chr12_105065797_105066143 0.15 ENSG00000264295
 .
 80559
 0.1
chr6_116832868_116833176 0.15 FAM26E
 family with sequence similarity 26, member E
 213
 0.73
chr3_75690482_75691208 0.14 ENSG00000221795
 .
 10931
 0.2
chr2_60808641_60809007 0.14 BCL11A
 B-cell CLL/lymphoma 11A (zinc finger protein)
 28122
 0.19
chr11_122513572_122513810 0.14 UBASH3B
 ubiquitin associated and SH3 domain containing B
 12692
 0.24
chr9_123698545_123698822 0.14 TRAF1
 TNF receptor-associated factor 1
 7232
 0.23
chr15_39871853_39872515 0.14 THBS1
 thrombospondin 1
 1096
 0.52
chrX_99904753_99905093 0.14 SRPX2
 sushi-repeat containing protein, X-linked 2
 5708
 0.19
chr5_167696137_167696498 0.14 WWC1
 WW and C2 domain containing 1
 22339
 0.2
chr1_8587025_8587260 0.14 RERE
 arginine-glutamic acid dipeptide (RE) repeats
 1056
 0.58
chr10_13748985_13749251 0.14 ENSG00000222235
 .
 2140
 0.21
chr2_47499719_47500092 0.14 EPCAM
 epithelial cell adhesion molecule
 72392
 0.09
chr4_142003365_142003602 0.14 RNF150
 ring finger protein 150
 28603
 0.25
chr9_75653628_75653779 0.14 ALDH1A1
 aldehyde dehydrogenase 1 family, member A1
 65
 0.99
chr15_98504600_98505000 0.14 ARRDC4
 arrestin domain containing 4
 872
 0.68
chr9_110250307_110251795 0.14 KLF4
 Kruppel-like factor 4 (gut)
 360
 0.89
chr20_31063509_31063841 0.14 C20orf112
 chromosome 20 open reading frame 112
 7599
 0.19
chr5_54864628_54864779 0.14 PPAP2A
 phosphatidic acid phosphatase type 2A
 33825
 0.18
chr10_14032873_14033043 0.14 RP11-142M10.2
857
 0.66
chr3_55519561_55519953 0.14 WNT5A
 wingless-type MMTV integration site family, member 5A
 1574
 0.4
chr19_44598113_44598899 0.14 ZNF224
 zinc finger protein 224
 14
 0.94
chr10_4284967_4285185 0.14 ENSG00000207124
 .
 272068
 0.02
chr5_54457024_54457471 0.14 GPX8
 glutathione peroxidase 8 (putative)
 1249
 0.31
chr12_116796712_116796969 0.14 ENSG00000264037
 .
 69283
 0.11
chr2_223912434_223912604 0.14 KCNE4
 potassium voltage-gated channel, Isk-related family, member 4
 4013
 0.33
chr10_65479976_65480138 0.14 REEP3
 receptor accessory protein 3
 198934
 0.03
chr1_59478905_59479109 0.14 JUN
 jun proto-oncogene
 229222
 0.02
chr1_224805949_224806359 0.14 CNIH3
 cornichon family AMPA receptor auxiliary protein 3
 2159
 0.29
chr8_101555325_101555476 0.14 ANKRD46
 ankyrin repeat domain 46
 9847
 0.18
chr7_28944342_28944522 0.14 CTB-113D17.1
75151
 0.1
chr6_81257814_81258158 0.14 BCKDHB
 branched chain keto acid dehydrogenase E1, beta polypeptide
 441603
 0.01
chr21_17497269_17497520 0.14 ENSG00000252273
 .
 89565
 0.1
chr20_10720180_10720390 0.14 JAG1
 jagged 1
 65591
 0.13
chr3_73119964_73120214 0.13 PPP4R2
 protein phosphatase 4, regulatory subunit 2
 6924
 0.14
chr18_46451248_46451445 0.13 SMAD7
 SMAD family member 7
 23529
 0.22
chr14_27244705_27244856 0.13 NOVA1-AS1
 NOVA1 antisense RNA 1 (head to head)
 6594
 0.31
chr3_177002301_177002503 0.13 TBL1XR1
 transducin (beta)-like 1 X-linked receptor 1
 87141
 0.1
chr10_113595251_113595472 0.13 GPAM
 glycerol-3-phosphate acyltransferase, mitochondrial
 348107
 0.01
chr14_52518827_52518978 0.13 NID2
 nidogen 2 (osteonidogen)
 13232
 0.2
chr3_147140468_147140953 0.13 ZIC1
 Zic family member 1
 13539
 0.19
chr19_46920028_46920207 0.13 CCDC8
 coiled-coil domain containing 8
 3276
 0.17
chrX_41449282_41449446 0.13 CASK
 calcium/calmodulin-dependent serine protein kinase (MAGUK family)
 160
 0.95
chr2_199364486_199364637 0.13 ENSG00000252511
 .
 66892
 0.15
chr13_34083543_34083799 0.13 STARD13
 StAR-related lipid transfer (START) domain containing 13
 158904
 0.04
chr3_120216529_120216680 0.13 FSTL1
 follistatin-like 1
 46504
 0.16
chr4_140807822_140807973 0.13 MAML3
 mastermind-like 3 (Drosophila)
 3309
 0.35
chr9_110310779_110311295 0.13 KLF4
 Kruppel-like factor 4 (gut)
 58274
 0.13
chr17_41622177_41622554 0.13 RP11-392O1.4
212
 0.81
chr11_65666484_65666730 0.13 FOSL1
 FOS-like antigen 1
 1283
 0.23
chr13_75466427_75466770 0.13 ENSG00000206812
 .
 217126
 0.02
chr2_173037089_173037327 0.13 ENSG00000238572
 .
 16360
 0.23
chr1_231002889_231003524 0.13 C1orf198
 chromosome 1 open reading frame 198
 1193
 0.37
chr4_120613511_120613662 0.13 PDE5A
 phosphodiesterase 5A, cGMP-specific
 63440
 0.14
chr12_5542106_5542552 0.13 NTF3
 neurotrophin 3
 1050
 0.7
chr12_12111873_12112098 0.13 ETV6
 ets variant 6
 73114
 0.11
chr2_181388274_181388425 0.13 ENSG00000264976
 .
 93584
 0.1
chr4_187491209_187491867 0.13 MTNR1A
 melatonin receptor 1A
 14817
 0.17
chr5_65265501_65265702 0.13 ENSG00000252904
 .
 8454
 0.24
chr1_92330105_92330395 0.13 TGFBR3
 transforming growth factor, beta receptor III
 3100
 0.29
chr1_1207989_1209115 0.13 UBE2J2
 ubiquitin-conjugating enzyme E2, J2
 299
 0.76
chr17_79361759_79361910 0.13 RP11-1055B8.6
 Uncharacterized protein
 7441
 0.12
chr1_1934983_1935264 0.13 C1orf222
 chromosome 1 open reading frame 222
 30
 0.96
chr18_7460286_7460529 0.13 PTPRM
 protein tyrosine phosphatase, receptor type, M
 106373
 0.07
chr19_45720617_45720890 0.13 EXOC3L2
 exocyst complex component 3-like 2
 14385
 0.11
chr11_116857809_116858077 0.13 ENSG00000264344
 .
 28302
 0.13
chr3_117419873_117420024 0.13 ENSG00000206889
 .
 156896
 0.04
chr5_179758220_179758506 0.13 GFPT2
 glutamine-fructose-6-phosphate transaminase 2
 285
 0.91
chr12_66222800_66222951 0.13 HMGA2
 high mobility group AT-hook 2
 3972
 0.25
chr6_152450893_152451044 0.13 SYNE1
 spectrin repeat containing, nuclear envelope 1
 38518
 0.22
chr9_111206714_111207024 0.13 ENSG00000222512
 .
 85660
 0.11
chr6_74406883_74407034 0.13 RP11-553A21.3
1104
 0.37
chr3_130236746_130236897 0.13 COL6A6
 collagen, type VI, alpha 6
 42357
 0.18

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.2 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1 0.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.2 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.2 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.0 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.0 0.1 GO:0031223 response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.2 GO:0090177 establishment of planar polarity involved in neural tube closure(GO:0090177)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.1 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0 0.1 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.0 0.1 GO:2000188 regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0051927 obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0 0.1 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.1 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.2 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.2 GO:0001738 morphogenesis of a polarized epithelium(GO:0001738)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 0.0 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.0 GO:0010159 specification of organ position(GO:0010159)
0.0 0.1 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.2 GO:0006067 ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.1 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.1 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.0 GO:0072071 mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.0 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.0 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:2001280 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.0 GO:0070141 response to UV-A(GO:0070141)
0.0 0.0 GO:0071694 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.0 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.1 GO:0010544 negative regulation of platelet activation(GO:0010544)
0.0 0.2 GO:0002675 positive regulation of acute inflammatory response(GO:0002675)
0.0 0.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.0 GO:0046618 drug export(GO:0046618)
0.0 0.0 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.1 GO:0021781 glial cell fate commitment(GO:0021781)
0.0 0.0 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.0 GO:0014824 tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0 0.0 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:0008347 glial cell migration(GO:0008347)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.0 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.0 GO:0060027 convergent extension involved in gastrulation(GO:0060027)
0.0 0.1 GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.0 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.0 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.0 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0 0.0 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.0 GO:0008049 male courtship behavior(GO:0008049)
0.0 0.0 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.0 GO:0072583 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.3 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0 0.0 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.2 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.0 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.0 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0031105 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0043205 fibril(GO:0043205)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.1 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.2 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.2 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.2 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.0 GO:0030172 troponin C binding(GO:0030172)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.0 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0005109 frizzled binding(GO:0005109)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)
0.0 0.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.0 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.0 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.0 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 ST ADRENERGIC Adrenergic Pathway
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction