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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for STAT6

Z-value: 1.13

Motif logo

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Transcription factors associated with STAT6

Gene Symbol Gene ID Gene Info
STAT6
ENSG00000166888.6 signal transducer and activator of transcription 6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr12_57525719_57525870STAT61280.922215-0.722.9e-02Click!
chr12_57529685_57529883STAT638620.121280-0.684.5e-02Click!
chr12_57524952_57525103STAT68950.387758-0.675.0e-02Click!
chr12_57526685_57526895STAT68680.413961-0.665.3e-02Click!
chr12_57526448_57526635STAT66190.555722-0.646.5e-02Click!

Activity of the STAT6 motif across conditions

Conditions sorted by the z-value of the STAT6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_160766445_160766727 0.61 LY9
 lymphocyte antigen 9
 609
 0.72
chr14_22789744_22789895 0.61 ENSG00000251002
 .
 111900
 0.05
chr12_47611625_47611801 0.53 PCED1B
 PC-esterase domain containing 1B
 1332
 0.49
chr1_160616915_160617313 0.52 SLAMF1
 signaling lymphocytic activation molecule family member 1
 29
 0.97
chr10_6103670_6104125 0.49 IL2RA
 interleukin 2 receptor, alpha
 356
 0.84
chr5_133452105_133452343 0.48 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 908
 0.64
chr22_40299734_40299885 0.48 GRAP2
 GRB2-related adaptor protein 2
 2696
 0.25
chr13_99957510_99957765 0.45 GPR183
 G protein-coupled receptor 183
 2022
 0.34
chr1_167486584_167486784 0.45 CD247
 CD247 molecule
 1091
 0.54
chr14_99734042_99734488 0.44 BCL11B
 B-cell CLL/lymphoma 11B (zinc finger protein)
 3300
 0.26
chr8_126963197_126963348 0.42 ENSG00000206695
 .
 50077
 0.19
chr10_73846546_73846733 0.41 SPOCK2
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
 1447
 0.48
chr6_144665292_144666004 0.37 UTRN
 utrophin
 411
 0.88
chr14_99726303_99726510 0.37 AL109767.1
2879
 0.29
chr3_73126790_73126941 0.36 ENSG00000238416
 .
 4273
 0.16
chr17_33566033_33566184 0.36 RP11-799D4.4
1108
 0.42
chr17_33568427_33568649 0.35 RP11-799D4.4
1444
 0.28
chr11_2322790_2323148 0.35 C11orf21
 chromosome 11 open reading frame 21
 174
 0.62
chr8_134069781_134069970 0.35 SLA
 Src-like-adaptor
 2728
 0.34
chr18_67623543_67623764 0.33 CD226
 CD226 molecule
 253
 0.95
chr8_134084186_134084496 0.33 SLA
 Src-like-adaptor
 11738
 0.24
chr12_6555099_6555250 0.33 CD27
 CD27 molecule
 1141
 0.3
chr7_3083802_3083953 0.33 CARD11
 caspase recruitment domain family, member 11
 298
 0.93
chr8_38219852_38220003 0.33 WHSC1L1
 Wolf-Hirschhorn syndrome candidate 1-like 1
 18412
 0.12
chr6_93898534_93898685 0.33 EPHA7
 EPH receptor A7
 230635
 0.02
chr1_192545263_192545458 0.32 RGS1
 regulator of G-protein signaling 1
 457
 0.84
chr18_2982488_2982849 0.32 LPIN2
 lipin 2
 203
 0.93
chr7_150148744_150149359 0.32 GIMAP8
 GTPase, IMAP family member 8
 1333
 0.41
chrY_16636977_16637245 0.31 NLGN4Y
 neuroligin 4, Y-linked
 657
 0.84
chr6_122729994_122730284 0.31 HSF2
 heat shock transcription factor 2
 9443
 0.26
chr4_109084692_109084886 0.31 LEF1
 lymphoid enhancer-binding factor 1
 2668
 0.31
chr7_1086655_1086891 0.30 GPR146
 G protein-coupled receptor 146
 2561
 0.15
chr11_413234_413456 0.30 SIGIRR
 single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
 1603
 0.21
chr2_106473982_106474172 0.30 AC009505.2
444
 0.86
chr14_99708890_99709242 0.29 AL109767.1
20219
 0.2
chr6_24930869_24931159 0.29 FAM65B
 family with sequence similarity 65, member B
 5174
 0.26
chr9_136006193_136006379 0.29 RALGDS
 ral guanine nucleotide dissociation stimulator
 218
 0.91
chr18_2981451_2981852 0.29 LPIN2
 lipin 2
 1220
 0.42
chr10_100503637_100503788 0.28 HPS1
 Hermansky-Pudlak syndrome 1
 297029
 0.01
chr13_42848803_42848954 0.28 AKAP11
 A kinase (PRKA) anchor protein 11
 2589
 0.4
chr5_118693818_118693969 0.28 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 2163
 0.35
chr13_52516667_52516944 0.28 ATP7B
 ATPase, Cu++ transporting, beta polypeptide
 19246
 0.2
chr5_130617597_130618118 0.28 CDC42SE2
 CDC42 small effector 2
 18064
 0.27
chr18_60819434_60819585 0.27 RP11-299P2.1
956
 0.65
chr14_35399812_35400018 0.27 ENSG00000199980
 .
 2834
 0.24
chr16_78776576_78776802 0.27 RP11-319G9.3
154373
 0.04
chr12_109026876_109027027 0.27 SELPLG
 selectin P ligand
 719
 0.55
chr10_127686444_127686595 0.27 FANK1
 fibronectin type III and ankyrin repeat domains 1
 2533
 0.31
chr6_35267244_35267414 0.27 DEF6
 differentially expressed in FDCP 6 homolog (mouse)
 1700
 0.35
chr14_100539294_100539636 0.26 CTD-2376I20.1
1750
 0.29
chr8_8203535_8203805 0.26 SGK223
 Tyrosine-protein kinase SgK223
 35587
 0.18
chr4_122103035_122103186 0.26 ENSG00000252183
 .
 10948
 0.22
chrY_21906454_21906814 0.26 KDM5D
 lysine (K)-specific demethylase 5D
 13
 0.99
chr1_241715487_241715755 0.26 KMO
 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
 16314
 0.2
chr2_109605420_109605703 0.26 EDAR
 ectodysplasin A receptor
 164
 0.97
chr12_9819897_9820101 0.26 CLEC2D
 C-type lectin domain family 2, member D
 2310
 0.2
chr14_99727366_99727576 0.26 AL109767.1
1814
 0.39
chr3_69249720_69249913 0.26 FRMD4B
 FERM domain containing 4B
 183
 0.96
chr11_46352507_46352658 0.26 DGKZ
 diacylglycerol kinase, zeta
 1873
 0.29
chr9_114836879_114837030 0.26 RP11-4O1.2
36944
 0.14
chr1_111214730_111214881 0.26 KCNA3
 potassium voltage-gated channel, shaker-related subfamily, member 3
 2850
 0.25
chr4_26398560_26398711 0.26 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 31707
 0.23
chr9_95727852_95728104 0.25 FGD3
 FYVE, RhoGEF and PH domain containing 3
 1735
 0.41
chr11_66795405_66795556 0.25 SYT12
 synaptotagmin XII
 449
 0.77
chr4_40195304_40195587 0.25 RHOH
 ras homolog family member H
 162
 0.96
chr14_22974481_22974956 0.25 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 18547
 0.09
chr3_46396239_46396534 0.25 CCR2
 chemokine (C-C motif) receptor 2
 769
 0.62
chr1_186291714_186291865 0.25 ENSG00000202025
 .
 10729
 0.17
chr1_154300198_154300512 0.24 ATP8B2
 ATPase, aminophospholipid transporter, class I, type 8B, member 2
 79
 0.94
chr10_62492315_62493446 0.24 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 368
 0.92
chr5_35857058_35857643 0.24 IL7R
 interleukin 7 receptor
 356
 0.89
chr3_151973155_151973306 0.24 MBNL1
 muscleblind-like splicing regulator 1
 12599
 0.22
chr7_90742755_90742906 0.24 FZD1
 frizzled family receptor 1
 150953
 0.05
chr2_161994699_161994850 0.24 TANK
 TRAF family member-associated NFKB activator
 1308
 0.52
chr14_102280065_102280216 0.24 CTD-2017C7.2
3482
 0.18
chr7_107045766_107045917 0.24 GPR22
 G protein-coupled receptor 22
 64664
 0.11
chr9_78639191_78639342 0.24 PCSK5
 proprotein convertase subtilisin/kexin type 5
 71627
 0.13
chr2_68961577_68961872 0.24 ARHGAP25
 Rho GTPase activating protein 25
 189
 0.96
chr9_130666902_130667485 0.24 ST6GALNAC6
 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
 416
 0.68
chr21_19165639_19165946 0.23 AL109761.5
13
 0.98
chr13_49391256_49391452 0.23 ENSG00000222391
 .
 65062
 0.12
chr4_36244120_36244417 0.23 ARAP2
 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
 1293
 0.39
chr17_41738444_41738624 0.23 MEOX1
 mesenchyme homeobox 1
 397
 0.85
chr8_22552129_22552945 0.23 EGR3
 early growth response 3
 1722
 0.26
chr1_153513589_153513800 0.23 S100A5
 S100 calcium binding protein A5
 524
 0.57
chr17_6949635_6950042 0.23 SLC16A11
 solute carrier family 16, member 11
 2596
 0.11
chr3_156201429_156202178 0.23 KCNAB1-AS1
 KCNAB1 antisense RNA 1
 37109
 0.17
chr13_23174183_23174334 0.23 ENSG00000253094
 .
 203026
 0.03
chr16_26606103_26606254 0.23 ENSG00000264935
 .
 141372
 0.05
chr2_225811162_225811313 0.22 DOCK10
 dedicator of cytokinesis 10
 545
 0.86
chr15_78361308_78361764 0.22 TBC1D2B
 TBC1 domain family, member 2B
 3071
 0.18
chr6_18348172_18348323 0.22 RNF144B
 ring finger protein 144B
 20532
 0.18
chr10_32748199_32748350 0.22 CCDC7
 coiled-coil domain containing 7
 7725
 0.23
chr11_128700598_128700752 0.22 KCNJ1
 potassium inwardly-rectifying channel, subfamily J, member 1
 11754
 0.2
chr1_169679248_169679951 0.22 SELL
 selectin L
 1240
 0.48
chr8_80268950_80269101 0.22 STMN2
 stathmin-like 2
 254024
 0.02
chr3_43736623_43736774 0.22 ANO10
 anoctamin 10
 3612
 0.27
chr11_14097283_14097490 0.21 ENSG00000212365
 .
 59146
 0.15
chr6_159461701_159461911 0.21 TAGAP
 T-cell activation RhoGTPase activating protein
 4244
 0.22
chr11_6764514_6764763 0.21 GVINP1
 GTPase, very large interferon inducible pseudogene 1
 21527
 0.11
chr4_38513548_38513699 0.21 RP11-617D20.1
112573
 0.06
chr4_70625874_70626025 0.21 SULT1B1
 sulfotransferase family, cytosolic, 1B, member 1
 367
 0.91
chr13_48894505_48894712 0.21 RB1
 retinoblastoma 1
 16697
 0.25
chr5_39197523_39197702 0.21 FYB
 FYN binding protein
 5517
 0.3
chr6_45982173_45982324 0.21 CLIC5
 chloride intracellular channel 5
 1317
 0.48
chr4_187639922_187640073 0.21 FAT1
 FAT atypical cadherin 1
 5012
 0.32
chr7_138788632_138788799 0.20 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
 5385
 0.23
chr3_5178219_5178370 0.20 ARL8B
 ADP-ribosylation factor-like 8B
 14313
 0.17
chr14_50448972_50449232 0.20 C14orf182
 chromosome 14 open reading frame 182
 25136
 0.15
chr14_55852967_55853226 0.20 ATG14
 autophagy related 14
 25480
 0.18
chr15_38855839_38856970 0.20 RASGRP1
 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
 432
 0.84
chr8_128987632_128988045 0.20 ENSG00000221771
 .
 14959
 0.16
chr13_40532608_40532878 0.20 ENSG00000212553
 .
 101379
 0.08
chr5_40684769_40685057 0.20 PTGER4
 prostaglandin E receptor 4 (subtype EP4)
 5313
 0.23
chr21_38352575_38353327 0.20 HLCS
 holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
 23
 0.97
chr3_128838297_128838517 0.20 RAB43
 RAB43, member RAS oncogene family
 2217
 0.2
chr10_105453143_105453834 0.20 SH3PXD2A
 SH3 and PX domains 2A
 558
 0.78
chr1_117515195_117515346 0.20 ENSG00000252510
 .
 10177
 0.17
chr8_59352943_59353094 0.20 UBXN2B
 UBX domain protein 2B
 23529
 0.23
chr4_150907034_150907185 0.20 ENSG00000207121
 .
 51581
 0.16
chrY_16635792_16636017 0.20 NLGN4Y
 neuroligin 4, Y-linked
 278
 0.96
chr1_62905567_62905816 0.19 USP1
 ubiquitin specific peptidase 1
 3365
 0.33
chr2_235359845_235359996 0.19 ARL4C
 ADP-ribosylation factor-like 4C
 45324
 0.21
chr6_117870110_117870478 0.19 GOPC
 golgi-associated PDZ and coiled-coil motif containing
 53233
 0.12
chr13_97877051_97877292 0.19 MBNL2
 muscleblind-like splicing regulator 2
 2562
 0.41
chr13_99992644_99992897 0.19 ENSG00000207719
 .
 15615
 0.19
chr5_130588828_130589214 0.19 CDC42SE2
 CDC42 small effector 2
 10681
 0.28
chr2_114652613_114652764 0.19 ACTR3
 ARP3 actin-related protein 3 homolog (yeast)
 4513
 0.26
chr10_15296464_15296906 0.19 RP11-25G10.2
17194
 0.24
chr22_40858602_40858925 0.19 MKL1
 megakaryoblastic leukemia (translocation) 1
 659
 0.7
chrY_15815919_15816489 0.19 TMSB4Y
 thymosin beta 4, Y-linked
 757
 0.72
chr3_128835091_128835242 0.19 RAB43
 RAB43, member RAS oncogene family
 5458
 0.13
chrX_64893704_64894104 0.19 MSN
 moesin
 6367
 0.32
chr5_39207439_39207590 0.19 FYB
 FYN binding protein
 4385
 0.32
chr12_40022874_40023025 0.19 C12orf40
 chromosome 12 open reading frame 40
 2964
 0.31
chr5_110565458_110565614 0.19 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 5752
 0.25
chr4_122103316_122103738 0.18 ENSG00000252183
 .
 10531
 0.22
chr2_238609518_238609709 0.18 LRRFIP1
 leucine rich repeat (in FLII) interacting protein 1
 8631
 0.24
chr22_33278140_33278291 0.18 TIMP3
 TIMP metallopeptidase inhibitor 3
 80528
 0.1
chr9_132890907_132891166 0.18 ENSG00000223188
 .
 7951
 0.19
chr6_109694670_109694821 0.18 CD164
 CD164 molecule, sialomucin
 8158
 0.15
chr4_40230569_40230720 0.18 RHOH
 ras homolog family member H
 28680
 0.18
chr7_69471547_69471698 0.18 AUTS2
 autism susceptibility candidate 2
 407025
 0.01
chr13_41578397_41578548 0.18 ELF1
 E74-like factor 1 (ets domain transcription factor)
 14978
 0.19
chrX_46436832_46437001 0.18 CHST7
 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
 3697
 0.27
chr7_43626236_43626525 0.18 STK17A
 serine/threonine kinase 17a
 3716
 0.23
chr1_4558588_4558739 0.18 AJAP1
 adherens junctions associated protein 1
 156129
 0.04
chr22_33040985_33041136 0.18 ENSG00000251890
 .
 9876
 0.25
chr4_40213524_40213675 0.18 RHOH
 ras homolog family member H
 11635
 0.22
chr21_42798492_42799079 0.18 MX1
 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
 617
 0.73
chrX_12991303_12991531 0.18 TMSB4X
 thymosin beta 4, X-linked
 1810
 0.41
chr1_92846684_92846835 0.18 ENSG00000242764
 .
 21483
 0.21
chr5_175080247_175080498 0.18 HRH2
 histamine receptor H2
 4661
 0.24
chr2_9922535_9922686 0.18 ENSG00000200034
 .
 41698
 0.16
chr17_38721330_38721617 0.18 CCR7
 chemokine (C-C motif) receptor 7
 238
 0.92
chr2_20776643_20776868 0.18 HS1BP3-IT1
 HS1BP3 intronic transcript 1 (non-protein coding)
 15553
 0.21
chr2_27485345_27486489 0.18 SLC30A3
 solute carrier family 30 (zinc transporter), member 3
 178
 0.89
chr14_90147435_90147962 0.17 ENSG00000252655
 .
 30451
 0.14
chrX_48542477_48542733 0.17 WAS
 Wiskott-Aldrich syndrome
 437
 0.75
chr1_7999953_8000204 0.17 TNFRSF9
 tumor necrosis factor receptor superfamily, member 9
 848
 0.6
chr17_79025867_79026018 0.17 BAIAP2
 BAI1-associated protein 2
 1220
 0.37
chr6_10529624_10529892 0.17 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
 1169
 0.49
chr5_159903210_159903361 0.17 ENSG00000265237
 .
 1876
 0.31
chr8_37751638_37751789 0.17 RAB11FIP1
 RAB11 family interacting protein 1 (class I)
 5259
 0.15
chrX_103357104_103358067 0.17 ZCCHC18
 zinc finger, CCHC domain containing 18
 383
 0.86
chr1_9713063_9713437 0.17 C1orf200
 chromosome 1 open reading frame 200
 1394
 0.31
chr10_121965154_121965305 0.17 ENSG00000221402
 .
 81491
 0.11
chrY_7542080_7542231 0.17 RFTN1P1
 raftlin, lipid raft linker 1 pseudogene 1
 102593
 0.08
chr3_16329082_16329264 0.17 OXNAD1
 oxidoreductase NAD-binding domain containing 1
 18425
 0.15
chr7_102489527_102489678 0.17 ENSG00000238324
 .
 8295
 0.18
chr3_171852368_171852519 0.17 FNDC3B
 fibronectin type III domain containing 3B
 7679
 0.29
chr12_88222507_88222658 0.17 C12orf50
 chromosome 12 open reading frame 50
 199158
 0.03
chr11_88087417_88087693 0.17 CTSC
 cathepsin C
 16600
 0.28
chr6_144881069_144881220 0.17 UTRN
 utrophin
 23202
 0.28
chr12_92899150_92899489 0.17 ENSG00000238865
 .
 39444
 0.17
chr2_30459993_30460144 0.17 LBH
 limb bud and heart development
 5022
 0.26
chr3_63338970_63339121 0.16 ENSG00000252662
 .
 18582
 0.26
chr17_33864237_33864745 0.16 SLFN12L
 schlafen family member 12-like
 389
 0.76
chr14_82916567_82916718 0.16 ENSG00000238978
 .
 11790
 0.33
chr11_113730700_113730851 0.16 ENSG00000201687
 .
 707
 0.64
chr3_177314905_177315095 0.16 ENSG00000200288
 .
 27197
 0.25
chr1_47109278_47109429 0.16 ATPAF1
 ATP synthase mitochondrial F1 complex assembly factor 1
 1575
 0.3
chr10_33415014_33415165 0.16 ENSG00000263576
 .
 27525
 0.2
chr2_29121252_29121403 0.16 WDR43
 WD repeat domain 43
 2657
 0.17
chr10_5752759_5752996 0.16 RP11-336A10.2
3509
 0.22
chr1_167059294_167059481 0.16 GPA33
 glycoprotein A33 (transmembrane)
 481
 0.77
chr2_85830286_85830577 0.16 TMEM150A
 transmembrane protein 150A
 610
 0.53
chr1_40848541_40848692 0.16 SMAP2
 small ArfGAP2
 8296
 0.18
chr1_165393515_165393674 0.16 RXRG
 retinoid X receptor, gamma
 20839
 0.21
chr14_55598726_55598877 0.16 LGALS3
 lectin, galactoside-binding, soluble, 3
 2823
 0.31
chr2_107128169_107128320 0.16 CD8BP
 CD8b molecule pseudogene
 24361
 0.18
chrX_106070087_106070238 0.15 TBC1D8B
 TBC1 domain family, member 8B (with GRAM domain)
 8535
 0.25
chr1_9473851_9474134 0.15 ENSG00000252956
 .
 23845
 0.2
chr1_108211265_108211416 0.15 VAV3
 vav 3 guanine nucleotide exchange factor
 19786
 0.27
chr19_17862777_17862928 0.15 FCHO1
 FCH domain only 1
 507
 0.71
chr7_105902270_105902421 0.15 NAMPT
 nicotinamide phosphoribosyltransferase
 23022
 0.19
chr16_74732357_74732554 0.15 MLKL
 mixed lineage kinase domain-like
 2233
 0.3
chr2_30458431_30458703 0.15 LBH
 limb bud and heart development
 3521
 0.29
chr17_39810938_39811089 0.15 KRT42P
 keratin 42 pseudogene
 24169
 0.09
chr6_109803101_109803270 0.15 ZBTB24
 zinc finger and BTB domain containing 24
 1255
 0.32

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008049 male courtship behavior(GO:0008049)
0.1 0.4 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.1 0.2 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.1 0.4 GO:0070670 response to interleukin-4(GO:0070670)
0.1 0.3 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 0.3 GO:0042989 sequestering of actin monomers(GO:0042989)
0.1 0.2 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.3 GO:0002855 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.1 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1 0.2 GO:0001757 somite specification(GO:0001757)
0.1 0.2 GO:0070602 centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.1 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.5 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.0 0.2 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.3 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.0 0.1 GO:0071354 cellular response to interleukin-6(GO:0071354)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.1 GO:0033261 obsolete regulation of S phase(GO:0033261)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0007619 courtship behavior(GO:0007619)
0.0 0.1 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.3 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0032278 positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.1 GO:0032875 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.0 GO:0051138 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.0 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.1 GO:0009296 obsolete flagellum assembly(GO:0009296)
0.0 0.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.0 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0 0.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.0 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.0 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0021612 cranial nerve structural organization(GO:0021604) facial nerve morphogenesis(GO:0021610) facial nerve structural organization(GO:0021612)
0.0 0.0 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.1 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.1 GO:0044380 protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.1 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 0.0 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.0 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.0 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.0 GO:0035610 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0045683 negative regulation of epidermis development(GO:0045683)
0.0 0.0 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.0 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.0 GO:1900120 regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0 0.1 GO:0090218 positive regulation of lipid kinase activity(GO:0090218)
0.0 0.0 GO:0031033 myosin filament organization(GO:0031033)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.0 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0002467 germinal center formation(GO:0002467)
0.0 0.0 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.0 GO:0015825 L-serine transport(GO:0015825)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.1 GO:1903561 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.0 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.0 GO:0042584 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0 0.4 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.1 0.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.7 GO:0003823 antigen binding(GO:0003823)
0.0 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.4 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0019863 IgE binding(GO:0019863)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.3 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.0 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.0 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.0 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.0 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.0 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.0 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 1.3 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.2 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.1 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.0 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network