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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for STAT6

Z-value: 1.13

Motif logo

Transcription factors associated with STAT6

Gene Symbol	Gene ID	Gene Info
STAT6 Ensembl NCBI GeneCards UniProt	ENSG00000166888.6	STAT6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
STAT6	chr12_57525719_57525870	128	0.922215	-0.72	2.9e-02	Click!
STAT6	chr12_57529685_57529883	3862	0.121280	-0.68	4.5e-02	Click!
STAT6	chr12_57524952_57525103	895	0.387758	-0.67	5.0e-02	Click!
STAT6	chr12_57526685_57526895	868	0.413961	-0.66	5.3e-02	Click!
STAT6	chr12_57526448_57526635	619	0.555722	-0.64	6.5e-02	Click!

Activity of the STAT6 motif across conditions

Conditions sorted by the z-value of the STAT6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_160766445_160766727	0.61	LY9	lymphocyte antigen 9	609	0.72
chr14_22789744_22789895	0.61	ENSG00000251002	.	111900	0.05
chr12_47611625_47611801	0.53	PCED1B	PC-esterase domain containing 1B	1332	0.49
chr1_160616915_160617313	0.52	SLAMF1	signaling lymphocytic activation molecule family member 1	29	0.97
chr10_6103670_6104125	0.49	IL2RA	interleukin 2 receptor, alpha	356	0.84
chr5_133452105_133452343	0.48	TCF7	transcription factor 7 (T-cell specific, HMG-box)	908	0.64
chr22_40299734_40299885	0.48	GRAP2	GRB2-related adaptor protein 2	2696	0.25
chr13_99957510_99957765	0.45	GPR183	G protein-coupled receptor 183	2022	0.34
chr1_167486584_167486784	0.45	CD247	CD247 molecule	1091	0.54
chr14_99734042_99734488	0.44	BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	3300	0.26
chr8_126963197_126963348	0.42	ENSG00000206695	.	50077	0.19
chr10_73846546_73846733	0.41	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	1447	0.48
chr6_144665292_144666004	0.37	UTRN	utrophin	411	0.88
chr14_99726303_99726510	0.37	AL109767.1		2879	0.29
chr3_73126790_73126941	0.36	ENSG00000238416	.	4273	0.16
chr17_33566033_33566184	0.36	RP11-799D4.4		1108	0.42
chr17_33568427_33568649	0.35	RP11-799D4.4		1444	0.28
chr11_2322790_2323148	0.35	C11orf21	chromosome 11 open reading frame 21	174	0.62
chr8_134069781_134069970	0.35	SLA	Src-like-adaptor	2728	0.34
chr18_67623543_67623764	0.33	CD226	CD226 molecule	253	0.95
chr8_134084186_134084496	0.33	SLA	Src-like-adaptor	11738	0.24
chr12_6555099_6555250	0.33	CD27	CD27 molecule	1141	0.3
chr7_3083802_3083953	0.33	CARD11	caspase recruitment domain family, member 11	298	0.93
chr8_38219852_38220003	0.33	WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	18412	0.12
chr6_93898534_93898685	0.33	EPHA7	EPH receptor A7	230635	0.02
chr1_192545263_192545458	0.32	RGS1	regulator of G-protein signaling 1	457	0.84
chr18_2982488_2982849	0.32	LPIN2	lipin 2	203	0.93
chr7_150148744_150149359	0.32	GIMAP8	GTPase, IMAP family member 8	1333	0.41
chrY_16636977_16637245	0.31	NLGN4Y	neuroligin 4, Y-linked	657	0.84
chr6_122729994_122730284	0.31	HSF2	heat shock transcription factor 2	9443	0.26
chr4_109084692_109084886	0.31	LEF1	lymphoid enhancer-binding factor 1	2668	0.31
chr7_1086655_1086891	0.30	GPR146	G protein-coupled receptor 146	2561	0.15
chr11_413234_413456	0.30	SIGIRR	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	1603	0.21
chr2_106473982_106474172	0.30	AC009505.2		444	0.86
chr14_99708890_99709242	0.29	AL109767.1		20219	0.2
chr6_24930869_24931159	0.29	FAM65B	family with sequence similarity 65, member B	5174	0.26
chr9_136006193_136006379	0.29	RALGDS	ral guanine nucleotide dissociation stimulator	218	0.91
chr18_2981451_2981852	0.29	LPIN2	lipin 2	1220	0.42
chr10_100503637_100503788	0.28	HPS1	Hermansky-Pudlak syndrome 1	297029	0.01
chr13_42848803_42848954	0.28	AKAP11	A kinase (PRKA) anchor protein 11	2589	0.4
chr5_118693818_118693969	0.28	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	2163	0.35
chr13_52516667_52516944	0.28	ATP7B	ATPase, Cu++ transporting, beta polypeptide	19246	0.2
chr5_130617597_130618118	0.28	CDC42SE2	CDC42 small effector 2	18064	0.27
chr18_60819434_60819585	0.27	RP11-299P2.1		956	0.65
chr14_35399812_35400018	0.27	ENSG00000199980	.	2834	0.24
chr16_78776576_78776802	0.27	RP11-319G9.3		154373	0.04
chr12_109026876_109027027	0.27	SELPLG	selectin P ligand	719	0.55
chr10_127686444_127686595	0.27	FANK1	fibronectin type III and ankyrin repeat domains 1	2533	0.31
chr6_35267244_35267414	0.27	DEF6	differentially expressed in FDCP 6 homolog (mouse)	1700	0.35
chr14_100539294_100539636	0.26	CTD-2376I20.1		1750	0.29
chr8_8203535_8203805	0.26	SGK223	Tyrosine-protein kinase SgK223	35587	0.18
chr4_122103035_122103186	0.26	ENSG00000252183	.	10948	0.22
chrY_21906454_21906814	0.26	KDM5D	lysine (K)-specific demethylase 5D	13	0.99
chr1_241715487_241715755	0.26	KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	16314	0.2
chr2_109605420_109605703	0.26	EDAR	ectodysplasin A receptor	164	0.97
chr12_9819897_9820101	0.26	CLEC2D	C-type lectin domain family 2, member D	2310	0.2
chr14_99727366_99727576	0.26	AL109767.1		1814	0.39
chr3_69249720_69249913	0.26	FRMD4B	FERM domain containing 4B	183	0.96
chr11_46352507_46352658	0.26	DGKZ	diacylglycerol kinase, zeta	1873	0.29
chr9_114836879_114837030	0.26	RP11-4O1.2		36944	0.14
chr1_111214730_111214881	0.26	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	2850	0.25
chr4_26398560_26398711	0.26	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	31707	0.23
chr9_95727852_95728104	0.25	FGD3	FYVE, RhoGEF and PH domain containing 3	1735	0.41
chr11_66795405_66795556	0.25	SYT12	synaptotagmin XII	449	0.77
chr4_40195304_40195587	0.25	RHOH	ras homolog family member H	162	0.96
chr14_22974481_22974956	0.25	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	18547	0.09
chr3_46396239_46396534	0.25	CCR2	chemokine (C-C motif) receptor 2	769	0.62
chr1_186291714_186291865	0.25	ENSG00000202025	.	10729	0.17
chr1_154300198_154300512	0.24	ATP8B2	ATPase, aminophospholipid transporter, class I, type 8B, member 2	79	0.94
chr10_62492315_62493446	0.24	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	368	0.92
chr5_35857058_35857643	0.24	IL7R	interleukin 7 receptor	356	0.89
chr3_151973155_151973306	0.24	MBNL1	muscleblind-like splicing regulator 1	12599	0.22
chr7_90742755_90742906	0.24	FZD1	frizzled family receptor 1	150953	0.05
chr2_161994699_161994850	0.24	TANK	TRAF family member-associated NFKB activator	1308	0.52
chr14_102280065_102280216	0.24	CTD-2017C7.2		3482	0.18
chr7_107045766_107045917	0.24	GPR22	G protein-coupled receptor 22	64664	0.11
chr9_78639191_78639342	0.24	PCSK5	proprotein convertase subtilisin/kexin type 5	71627	0.13
chr2_68961577_68961872	0.24	ARHGAP25	Rho GTPase activating protein 25	189	0.96
chr9_130666902_130667485	0.24	ST6GALNAC6	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	416	0.68
chr21_19165639_19165946	0.23	AL109761.5		13	0.98
chr13_49391256_49391452	0.23	ENSG00000222391	.	65062	0.12
chr4_36244120_36244417	0.23	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1293	0.39
chr17_41738444_41738624	0.23	MEOX1	mesenchyme homeobox 1	397	0.85
chr8_22552129_22552945	0.23	EGR3	early growth response 3	1722	0.26
chr1_153513589_153513800	0.23	S100A5	S100 calcium binding protein A5	524	0.57
chr17_6949635_6950042	0.23	SLC16A11	solute carrier family 16, member 11	2596	0.11
chr3_156201429_156202178	0.23	KCNAB1-AS1	KCNAB1 antisense RNA 1	37109	0.17
chr13_23174183_23174334	0.23	ENSG00000253094	.	203026	0.03
chr16_26606103_26606254	0.23	ENSG00000264935	.	141372	0.05
chr2_225811162_225811313	0.22	DOCK10	dedicator of cytokinesis 10	545	0.86
chr15_78361308_78361764	0.22	TBC1D2B	TBC1 domain family, member 2B	3071	0.18
chr6_18348172_18348323	0.22	RNF144B	ring finger protein 144B	20532	0.18
chr10_32748199_32748350	0.22	CCDC7	coiled-coil domain containing 7	7725	0.23
chr11_128700598_128700752	0.22	KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	11754	0.2
chr1_169679248_169679951	0.22	SELL	selectin L	1240	0.48
chr8_80268950_80269101	0.22	STMN2	stathmin-like 2	254024	0.02
chr3_43736623_43736774	0.22	ANO10	anoctamin 10	3612	0.27
chr11_14097283_14097490	0.21	ENSG00000212365	.	59146	0.15
chr6_159461701_159461911	0.21	TAGAP	T-cell activation RhoGTPase activating protein	4244	0.22
chr11_6764514_6764763	0.21	GVINP1	GTPase, very large interferon inducible pseudogene 1	21527	0.11
chr4_38513548_38513699	0.21	RP11-617D20.1		112573	0.06
chr4_70625874_70626025	0.21	SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	367	0.91
chr13_48894505_48894712	0.21	RB1	retinoblastoma 1	16697	0.25
chr5_39197523_39197702	0.21	FYB	FYN binding protein	5517	0.3
chr6_45982173_45982324	0.21	CLIC5	chloride intracellular channel 5	1317	0.48
chr4_187639922_187640073	0.21	FAT1	FAT atypical cadherin 1	5012	0.32
chr7_138788632_138788799	0.20	ZC3HAV1	zinc finger CCCH-type, antiviral 1	5385	0.23
chr3_5178219_5178370	0.20	ARL8B	ADP-ribosylation factor-like 8B	14313	0.17
chr14_50448972_50449232	0.20	C14orf182	chromosome 14 open reading frame 182	25136	0.15
chr14_55852967_55853226	0.20	ATG14	autophagy related 14	25480	0.18
chr15_38855839_38856970	0.20	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	432	0.84
chr8_128987632_128988045	0.20	ENSG00000221771	.	14959	0.16
chr13_40532608_40532878	0.20	ENSG00000212553	.	101379	0.08
chr5_40684769_40685057	0.20	PTGER4	prostaglandin E receptor 4 (subtype EP4)	5313	0.23
chr21_38352575_38353327	0.20	HLCS	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	23	0.97
chr3_128838297_128838517	0.20	RAB43	RAB43, member RAS oncogene family	2217	0.2
chr10_105453143_105453834	0.20	SH3PXD2A	SH3 and PX domains 2A	558	0.78
chr1_117515195_117515346	0.20	ENSG00000252510	.	10177	0.17
chr8_59352943_59353094	0.20	UBXN2B	UBX domain protein 2B	23529	0.23
chr4_150907034_150907185	0.20	ENSG00000207121	.	51581	0.16
chrY_16635792_16636017	0.20	NLGN4Y	neuroligin 4, Y-linked	278	0.96
chr1_62905567_62905816	0.19	USP1	ubiquitin specific peptidase 1	3365	0.33
chr2_235359845_235359996	0.19	ARL4C	ADP-ribosylation factor-like 4C	45324	0.21
chr6_117870110_117870478	0.19	GOPC	golgi-associated PDZ and coiled-coil motif containing	53233	0.12
chr13_97877051_97877292	0.19	MBNL2	muscleblind-like splicing regulator 2	2562	0.41
chr13_99992644_99992897	0.19	ENSG00000207719	.	15615	0.19
chr5_130588828_130589214	0.19	CDC42SE2	CDC42 small effector 2	10681	0.28
chr2_114652613_114652764	0.19	ACTR3	ARP3 actin-related protein 3 homolog (yeast)	4513	0.26
chr10_15296464_15296906	0.19	RP11-25G10.2		17194	0.24
chr22_40858602_40858925	0.19	MKL1	megakaryoblastic leukemia (translocation) 1	659	0.7
chrY_15815919_15816489	0.19	TMSB4Y	thymosin beta 4, Y-linked	757	0.72
chr3_128835091_128835242	0.19	RAB43	RAB43, member RAS oncogene family	5458	0.13
chrX_64893704_64894104	0.19	MSN	moesin	6367	0.32
chr5_39207439_39207590	0.19	FYB	FYN binding protein	4385	0.32
chr12_40022874_40023025	0.19	C12orf40	chromosome 12 open reading frame 40	2964	0.31
chr5_110565458_110565614	0.19	CAMK4	calcium/calmodulin-dependent protein kinase IV	5752	0.25
chr4_122103316_122103738	0.18	ENSG00000252183	.	10531	0.22
chr2_238609518_238609709	0.18	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	8631	0.24
chr22_33278140_33278291	0.18	TIMP3	TIMP metallopeptidase inhibitor 3	80528	0.1
chr9_132890907_132891166	0.18	ENSG00000223188	.	7951	0.19
chr6_109694670_109694821	0.18	CD164	CD164 molecule, sialomucin	8158	0.15
chr4_40230569_40230720	0.18	RHOH	ras homolog family member H	28680	0.18
chr7_69471547_69471698	0.18	AUTS2	autism susceptibility candidate 2	407025	0.01
chr13_41578397_41578548	0.18	ELF1	E74-like factor 1 (ets domain transcription factor)	14978	0.19
chrX_46436832_46437001	0.18	CHST7	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	3697	0.27
chr7_43626236_43626525	0.18	STK17A	serine/threonine kinase 17a	3716	0.23
chr1_4558588_4558739	0.18	AJAP1	adherens junctions associated protein 1	156129	0.04
chr22_33040985_33041136	0.18	ENSG00000251890	.	9876	0.25
chr4_40213524_40213675	0.18	RHOH	ras homolog family member H	11635	0.22
chr21_42798492_42799079	0.18	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	617	0.73
chrX_12991303_12991531	0.18	TMSB4X	thymosin beta 4, X-linked	1810	0.41
chr1_92846684_92846835	0.18	ENSG00000242764	.	21483	0.21
chr5_175080247_175080498	0.18	HRH2	histamine receptor H2	4661	0.24
chr2_9922535_9922686	0.18	ENSG00000200034	.	41698	0.16
chr17_38721330_38721617	0.18	CCR7	chemokine (C-C motif) receptor 7	238	0.92
chr2_20776643_20776868	0.18	HS1BP3-IT1	HS1BP3 intronic transcript 1 (non-protein coding)	15553	0.21
chr2_27485345_27486489	0.18	SLC30A3	solute carrier family 30 (zinc transporter), member 3	178	0.89
chr14_90147435_90147962	0.17	ENSG00000252655	.	30451	0.14
chrX_48542477_48542733	0.17	WAS	Wiskott-Aldrich syndrome	437	0.75
chr1_7999953_8000204	0.17	TNFRSF9	tumor necrosis factor receptor superfamily, member 9	848	0.6
chr17_79025867_79026018	0.17	BAIAP2	BAI1-associated protein 2	1220	0.37
chr6_10529624_10529892	0.17	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	1169	0.49
chr5_159903210_159903361	0.17	ENSG00000265237	.	1876	0.31
chr8_37751638_37751789	0.17	RAB11FIP1	RAB11 family interacting protein 1 (class I)	5259	0.15
chrX_103357104_103358067	0.17	ZCCHC18	zinc finger, CCHC domain containing 18	383	0.86
chr1_9713063_9713437	0.17	C1orf200	chromosome 1 open reading frame 200	1394	0.31
chr10_121965154_121965305	0.17	ENSG00000221402	.	81491	0.11
chrY_7542080_7542231	0.17	RFTN1P1	raftlin, lipid raft linker 1 pseudogene 1	102593	0.08
chr3_16329082_16329264	0.17	OXNAD1	oxidoreductase NAD-binding domain containing 1	18425	0.15
chr7_102489527_102489678	0.17	ENSG00000238324	.	8295	0.18
chr3_171852368_171852519	0.17	FNDC3B	fibronectin type III domain containing 3B	7679	0.29
chr12_88222507_88222658	0.17	C12orf50	chromosome 12 open reading frame 50	199158	0.03
chr11_88087417_88087693	0.17	CTSC	cathepsin C	16600	0.28
chr6_144881069_144881220	0.17	UTRN	utrophin	23202	0.28
chr12_92899150_92899489	0.17	ENSG00000238865	.	39444	0.17
chr2_30459993_30460144	0.17	LBH	limb bud and heart development	5022	0.26
chr3_63338970_63339121	0.16	ENSG00000252662	.	18582	0.26
chr17_33864237_33864745	0.16	SLFN12L	schlafen family member 12-like	389	0.76
chr14_82916567_82916718	0.16	ENSG00000238978	.	11790	0.33
chr11_113730700_113730851	0.16	ENSG00000201687	.	707	0.64
chr3_177314905_177315095	0.16	ENSG00000200288	.	27197	0.25
chr1_47109278_47109429	0.16	ATPAF1	ATP synthase mitochondrial F1 complex assembly factor 1	1575	0.3
chr10_33415014_33415165	0.16	ENSG00000263576	.	27525	0.2
chr2_29121252_29121403	0.16	WDR43	WD repeat domain 43	2657	0.17
chr10_5752759_5752996	0.16	RP11-336A10.2		3509	0.22
chr1_167059294_167059481	0.16	GPA33	glycoprotein A33 (transmembrane)	481	0.77
chr2_85830286_85830577	0.16	TMEM150A	transmembrane protein 150A	610	0.53
chr1_40848541_40848692	0.16	SMAP2	small ArfGAP2	8296	0.18
chr1_165393515_165393674	0.16	RXRG	retinoid X receptor, gamma	20839	0.21
chr14_55598726_55598877	0.16	LGALS3	lectin, galactoside-binding, soluble, 3	2823	0.31
chr2_107128169_107128320	0.16	CD8BP	CD8b molecule pseudogene	24361	0.18
chrX_106070087_106070238	0.15	TBC1D8B	TBC1 domain family, member 8B (with GRAM domain)	8535	0.25
chr1_9473851_9474134	0.15	ENSG00000252956	.	23845	0.2
chr1_108211265_108211416	0.15	VAV3	vav 3 guanine nucleotide exchange factor	19786	0.27
chr19_17862777_17862928	0.15	FCHO1	FCH domain only 1	507	0.71
chr7_105902270_105902421	0.15	NAMPT	nicotinamide phosphoribosyltransferase	23022	0.19
chr16_74732357_74732554	0.15	MLKL	mixed lineage kinase domain-like	2233	0.3
chr2_30458431_30458703	0.15	LBH	limb bud and heart development	3521	0.29
chr17_39810938_39811089	0.15	KRT42P	keratin 42 pseudogene	24169	0.09
chr6_109803101_109803270	0.15	ZBTB24	zinc finger and BTB domain containing 24	1255	0.32

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT6

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0008049	male courtship behavior(GO:0008049)
0.1	0.4	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.1	0.2	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.1	0.4	GO:0070670	response to interleukin-4(GO:0070670)
0.1	0.3	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1	0.3	GO:0042989	sequestering of actin monomers(GO:0042989)
0.1	0.2	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.3	GO:0002855	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.1	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.2	GO:0001757	somite specification(GO:0001757)
0.1	0.2	GO:0070602	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.1	0.2	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.5	GO:0045577	regulation of B cell differentiation(GO:0045577)
0.0	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.2	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.1	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.3	GO:0042403	thyroid hormone metabolic process(GO:0042403)
0.0	0.1	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0033261	obsolete regulation of S phase(GO:0033261)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0007619	courtship behavior(GO:0007619)
0.0	0.1	GO:0002093	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.3	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0032278	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0032875	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.0	GO:0051138	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.1	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.1	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.0	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.2	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.0	GO:2000400	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.3	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0021612	cranial nerve structural organization(GO:0021604) facial nerve morphogenesis(GO:0021610) facial nerve structural organization(GO:0021612)
0.0	0.0	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0045725	positive regulation of glycogen biosynthetic process(GO:0045725)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.0	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.0	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.0	GO:0035610	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0045683	negative regulation of epidermis development(GO:0045683)
0.0	0.0	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.0	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.0	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0090218	positive regulation of lipid kinase activity(GO:0090218)
0.0	0.0	GO:0031033	myosin filament organization(GO:0031033)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0002467	germinal center formation(GO:0002467)
0.0	0.0	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0015825	L-serine transport(GO:0015825)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.4	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.5	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.0	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.4	GO:0030175	filopodium(GO:0030175)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.3	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.5	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.3	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.2	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.5	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.4	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.3	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.7	GO:0003823	antigen binding(GO:0003823)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.2	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.4	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.3	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.0	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.0	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0	0.0	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.1	GO:0008187	poly-pyrimidine tract binding(GO:0008187)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.0	GO:0031544	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.0	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.0	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.8	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
1.3	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.2	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.2	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.8	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.4	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.4	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network