Project
ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TBX19

Z-value: 0.92

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Transcription factors associated with TBX19

Gene Symbol Gene ID Gene Info
TBX19
ENSG00000143178.8 TBX19

Activity of the TBX19 motif across conditions

Conditions sorted by the z-value of the TBX19 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_85479176_85479377 0.54 TBX18
 T-box 18
 5039
 0.33
chr8_49832237_49832502 0.49 SNAI2
 snail family zinc finger 2
 1619
 0.54
chr7_64895070_64895221 0.37 ZNF92
 zinc finger protein 92
 56351
 0.13
chr8_13371594_13371816 0.37 DLC1
 deleted in liver cancer 1
 569
 0.79
chr2_151334778_151334948 0.35 RND3
 Rho family GTPase 3
 7033
 0.34
chr4_81192543_81192855 0.34 FGF5
 fibroblast growth factor 5
 4906
 0.28
chr7_78398482_78399243 0.33 MAGI2
 membrane associated guanylate kinase, WW and PDZ domain containing 2
 1534
 0.56
chr18_56558977_56559159 0.32 ZNF532
 zinc finger protein 532
 26282
 0.16
chr8_89338531_89338740 0.32 RP11-586K2.1
430
 0.76
chr7_19145980_19146451 0.32 AC003986.6
5882
 0.17
chr12_47358106_47358377 0.32 PCED1B
 PC-esterase domain containing 1B
 115145
 0.06
chr6_3248086_3248639 0.31 PSMG4
 proteasome (prosome, macropain) assembly chaperone 4
 10766
 0.18
chr12_3069053_3070004 0.31 TEAD4
 TEA domain family member 4
 445
 0.77
chr3_98616375_98616538 0.31 DCBLD2
 discoidin, CUB and LCCL domain containing 2
 3559
 0.22
chr2_230035602_230035855 0.31 PID1
 phosphotyrosine interaction domain containing 1
 61073
 0.14
chr2_9347772_9348251 0.30 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 1117
 0.65
chr19_54057819_54058678 0.30 ZNF331
 zinc finger protein 331
 167
 0.9
chr13_33858654_33859881 0.29 STARD13
 StAR-related lipid transfer (START) domain containing 13
 625
 0.76
chr2_144692978_144693129 0.29 AC016910.1
1587
 0.49
chr3_69836526_69836696 0.28 ENSG00000241665
 .
 17683
 0.23
chr3_150132523_150132716 0.28 TSC22D2
 TSC22 domain family, member 2
 3823
 0.33
chr6_148664293_148664728 0.28 SASH1
 SAM and SH3 domain containing 1
 781
 0.74
chr10_95239197_95239357 0.28 MYOF
 myoferlin
 2674
 0.26
chr7_155592218_155592554 0.28 SHH
 sonic hedgehog
 9380
 0.23
chr8_134203052_134203203 0.28 WISP1
 WNT1 inducible signaling pathway protein 1
 155
 0.97
chr22_20119477_20120671 0.28 ZDHHC8
 zinc finger, DHHC-type containing 8
 603
 0.53
chr4_188523294_188523560 0.28 ZFP42
 ZFP42 zinc finger protein
 393498
 0.01
chr8_37350646_37351319 0.27 RP11-150O12.6
23557
 0.24
chr4_120970638_120970865 0.27 RP11-679C8.2
17362
 0.21
chr16_64927185_64927365 0.27 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 166306
 0.04
chr3_157262200_157262351 0.27 C3orf55
 chromosome 3 open reading frame 55
 1042
 0.6
chr5_141931000_141931262 0.26 ENSG00000252831
 .
 17221
 0.21
chr2_8055570_8055940 0.26 ENSG00000221255
 .
 338783
 0.01
chr8_32405226_32405421 0.26 NRG1
 neuregulin 1
 405
 0.92
chr3_29377379_29377667 0.26 ENSG00000216169
 .
 33389
 0.18
chr10_93391857_93392062 0.26 PPP1R3C
 protein phosphatase 1, regulatory subunit 3C
 852
 0.74
chr19_15333567_15333831 0.26 EPHX3
 epoxide hydrolase 3
 9544
 0.16
chr7_25889169_25889395 0.25 ENSG00000199085
 .
 100324
 0.08
chr10_52835110_52835261 0.25 PRKG1
 protein kinase, cGMP-dependent, type I
 1251
 0.52
chr10_60501911_60502062 0.25 BICC1
 bicaudal C homolog 1 (Drosophila)
 51309
 0.18
chrX_46186736_46187042 0.25 KRBOX4
 KRAB box domain containing 4
 119403
 0.06
chr19_16179581_16179939 0.25 TPM4
 tropomyosin 4
 1250
 0.44
chr7_44144273_44144986 0.25 AEBP1
 AE binding protein 1
 236
 0.84
chr12_64238850_64239338 0.25 SRGAP1
 SLIT-ROBO Rho GTPase activating protein 1
 553
 0.72
chr8_42063953_42065062 0.25 PLAT
 plasminogen activator, tissue
 576
 0.71
chr2_46928125_46928276 0.24 SOCS5
 suppressor of cytokine signaling 5
 1874
 0.38
chr5_63933889_63934062 0.24 FAM159B
 family with sequence similarity 159, member B
 52160
 0.14
chr20_19956550_19956867 0.24 NAA20
 N(alpha)-acetyltransferase 20, NatB catalytic subunit
 41052
 0.15
chr12_18449684_18450065 0.23 PIK3C2G
 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
 14896
 0.31
chr10_95240803_95240954 0.23 MYOF
 myoferlin
 1073
 0.51
chr3_147638936_147639087 0.23 ENSG00000221431
 .
 9723
 0.32
chr10_109674932_109675169 0.23 ENSG00000200079
 .
 453732
 0.01
chr10_63991622_63991773 0.23 RTKN2
 rhotekin 2
 4325
 0.32
chr3_141088214_141088426 0.23 RP11-438D8.2
2341
 0.33
chr2_205411137_205411321 0.23 PARD3B
 par-3 family cell polarity regulator beta
 506
 0.89
chr15_60688893_60689153 0.23 ANXA2
 annexin A2
 514
 0.85
chr22_39801235_39801470 0.23 TAB1
 TGF-beta activated kinase 1/MAP3K7 binding protein 1
 5563
 0.17
chr22_25346267_25346418 0.23 KIAA1671
 KIAA1671
 2355
 0.29
chr10_13748513_13748974 0.22 ENSG00000222235
 .
 1765
 0.25
chr4_99929189_99929340 0.22 ENSG00000265213
 .
 10726
 0.16
chr3_156873804_156874020 0.22 ENSG00000201778
 .
 2575
 0.21
chr4_187901481_187901677 0.22 ENSG00000252382
 .
 122969
 0.06
chr8_27729804_27730180 0.22 ENSG00000265847
 .
 13641
 0.16
chr3_42094199_42094430 0.22 TRAK1
 trafficking protein, kinesin binding 1
 38248
 0.19
chr16_69959859_69960167 0.22 WWP2
 WW domain containing E3 ubiquitin protein ligase 2
 1120
 0.44
chr19_11784446_11784993 0.21 CTC-499B15.4
8642
 0.14
chr4_170189368_170189538 0.21 SH3RF1
 SH3 domain containing ring finger 1
 1655
 0.5
chr11_69454351_69454502 0.21 CCND1
 cyclin D1
 1429
 0.47
chr10_123922760_123923208 0.21 TACC2
 transforming, acidic coiled-coil containing protein 2
 43
 0.99
chr6_24584146_24584297 0.21 KIAA0319
 KIAA0319
 61735
 0.09
chr2_24123591_24123937 0.21 ATAD2B
 ATPase family, AAA domain containing 2B
 26171
 0.17
chr3_65582462_65582613 0.21 MAGI1
 membrane associated guanylate kinase, WW and PDZ domain containing 1
 873
 0.76
chr1_61586210_61586441 0.21 RP4-802A10.1
4080
 0.27
chr2_45228184_45228926 0.21 SIX2
 SIX homeobox 2
 8014
 0.26
chr18_53090404_53090609 0.21 TCF4
 transcription factor 4
 763
 0.7
chr15_27508765_27508916 0.20 GABRG3
 gamma-aminobutyric acid (GABA) A receptor, gamma 3
 7849
 0.23
chr2_221940084_221940235 0.20 EPHA4
 EPH receptor A4
 427121
 0.01
chr2_238319908_238320059 0.20 COL6A3
 collagen, type VI, alpha 3
 2808
 0.28
chr9_17017802_17018053 0.20 ENSG00000241152
 .
 35972
 0.22
chr3_77090223_77090496 0.20 ROBO2
 roundabout, axon guidance receptor, homolog 2 (Drosophila)
 478
 0.88
chr17_29891051_29891281 0.20 ENSG00000221038
 .
 253
 0.86
chr2_158117199_158117478 0.20 GALNT5
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
 3228
 0.3
chr2_39750505_39750656 0.20 AC007246.3
4764
 0.3
chr11_7599067_7599755 0.20 PPFIBP2
 PTPRF interacting protein, binding protein 2 (liprin beta 2)
 1140
 0.49
chr3_168759646_168760009 0.20 MECOM
 MDS1 and EVI1 complex locus
 85995
 0.11
chr21_17677767_17678526 0.20 ENSG00000201025
 .
 21057
 0.28
chr11_62306171_62306793 0.20 RP11-864I4.3
1698
 0.19
chr4_158141912_158142089 0.20 GRIA2
 glutamate receptor, ionotropic, AMPA 2
 41
 0.98
chr2_26981186_26981361 0.20 SLC35F6
 solute carrier family 35, member F6
 5883
 0.19
chr2_192710921_192711254 0.20 AC098617.1
178
 0.9
chr4_189471544_189471830 0.20 ENSG00000252275
 .
 166192
 0.04
chr9_19378948_19379099 0.20 RPS6
 ribosomal protein S6
 1173
 0.37
chr7_73443076_73443679 0.20 ELN
 elastin
 859
 0.62
chr3_46854432_46854583 0.20 PRSS50
 protease, serine, 50
 443
 0.45
chr4_46935635_46935786 0.20 COX7B2
 cytochrome c oxidase subunit VIIb2
 24458
 0.22
chr13_42422903_42423054 0.20 ENSG00000241406
 .
 41165
 0.17
chr17_2499771_2499922 0.19 PAFAH1B1
 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
 2806
 0.23
chr8_126557270_126557537 0.19 ENSG00000266452
 .
 100596
 0.08
chr18_57170103_57170344 0.19 CCBE1
 collagen and calcium binding EGF domains 1
 22751
 0.19
chr2_119989088_119989281 0.19 STEAP3
 STEAP family member 3, metalloreductase
 7755
 0.2
chr8_93090595_93090746 0.19 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
 2306
 0.45
chr6_69346067_69346218 0.19 BAI3
 brain-specific angiogenesis inhibitor 3
 883
 0.52
chr2_190017431_190017582 0.19 ENSG00000264725
 .
 19669
 0.19
chr3_42922021_42922670 0.19 CYP8B1
 cytochrome P450, family 8, subfamily B, polypeptide 1
 4712
 0.15
chr5_110846365_110846666 0.19 STARD4-AS1
 STARD4 antisense RNA 1
 1409
 0.37
chr2_26240891_26241042 0.19 AC013449.1
 Uncharacterized protein
 10515
 0.17
chr2_33361191_33361342 0.19 LTBP1
 latent transforming growth factor beta binding protein 1
 1542
 0.54
chr15_59560315_59560475 0.19 RP11-429D19.1
2966
 0.2
chr1_51069078_51069376 0.19 FAF1
 Fas (TNFRSF6) associated factor 1
 8943
 0.23
chr5_159510080_159510300 0.19 PWWP2A
 PWWP domain containing 2A
 36239
 0.14
chr13_100635852_100636003 0.19 ZIC2
 Zic family member 2
 1901
 0.33
chr3_148734494_148734920 0.19 GYG1
 glycogenin 1
 24549
 0.16
chr4_110901886_110902148 0.19 ENSG00000207260
 .
 11464
 0.24
chr8_125212210_125212404 0.19 FER1L6-AS2
 FER1L6 antisense RNA 2
 28544
 0.2
chr7_55322762_55323341 0.19 EGFR-AS1
 EGFR antisense RNA 1
 66424
 0.13
chr16_81037098_81037249 0.19 CENPN
 centromere protein N
 2930
 0.16
chr3_25193145_25193356 0.19 RARB
 retinoic acid receptor, beta
 22573
 0.26
chr13_51971753_51971904 0.19 INTS6
 integrator complex subunit 6
 12428
 0.15
chr3_170136599_170137401 0.18 CLDN11
 claudin 11
 145
 0.97
chr19_47735595_47736220 0.18 BBC3
 BCL2 binding component 3
 116
 0.95
chr18_53067346_53067650 0.18 TCF4
 transcription factor 4
 1068
 0.61
chr5_111090218_111090459 0.18 NREP
 neuronal regeneration related protein
 1610
 0.42
chr16_3163066_3163293 0.18 ZNF205
 zinc finger protein 205
 383
 0.54
chr4_63575291_63575489 0.18 ENSG00000265085
 .
 114295
 0.07
chr2_36600561_36600712 0.18 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 17022
 0.28
chr6_18551314_18551465 0.18 ENSG00000207775
 .
 20626
 0.27
chr2_39964531_39964918 0.18 THUMPD2
 THUMP domain containing 2
 41565
 0.16
chr3_55520023_55520469 0.18 WNT5A
 wingless-type MMTV integration site family, member 5A
 1085
 0.48
chr22_34249489_34249782 0.18 LARGE
 like-glycosyltransferase
 7977
 0.27
chr12_50415148_50415300 0.18 RACGAP1
 Rac GTPase activating protein 1
 3959
 0.15
chr7_55196777_55196928 0.18 EGFR
 epidermal growth factor receptor
 19312
 0.25
chr22_31218163_31218918 0.18 OSBP2
 oxysterol binding protein 2
 37
 0.98
chr14_62169704_62169855 0.18 HIF1A
 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
 5439
 0.26
chr3_111487167_111487318 0.18 PHLDB2
 pleckstrin homology-like domain, family B, member 2
 35898
 0.18
chr5_82864302_82864453 0.18 VCAN-AS1
 VCAN antisense RNA 1
 6244
 0.28
chr8_57594130_57594603 0.18 RP11-17A4.2
192709
 0.03
chr5_72630160_72630334 0.18 FOXD1
 forkhead box D1
 114105
 0.06
chr3_61833858_61834009 0.18 ENSG00000252420
 .
 109030
 0.08
chr5_55193328_55193500 0.18 AC008914.1
 Uncharacterized protein
 31155
 0.14
chr13_75346514_75346665 0.18 ENSG00000206812
 .
 337135
 0.01
chr15_68573463_68573639 0.18 FEM1B
 fem-1 homolog b (C. elegans)
 1254
 0.47
chrX_139173235_139173445 0.18 ENSG00000241248
 .
 5326
 0.31
chr1_114522595_114522893 0.18 OLFML3
 olfactomedin-like 3
 49
 0.97
chr2_165463349_165463500 0.18 GRB14
 growth factor receptor-bound protein 14
 13043
 0.27
chr12_50608832_50609096 0.18 RP3-405J10.4
4423
 0.14
chr6_111925125_111925433 0.18 TRAF3IP2
 TRAF3 interacting protein 2
 1795
 0.32
chr10_121418043_121418219 0.18 BAG3
 BCL2-associated athanogene 3
 2009
 0.38
chr6_18434642_18434820 0.18 ENSG00000238458
 .
 32448
 0.19
chr2_42866321_42866472 0.18 ENSG00000194270
 .
 1295
 0.53
chr4_125866592_125866796 0.17 ANKRD50
 ankyrin repeat domain 50
 232807
 0.02
chr4_54172326_54172477 0.17 ENSG00000207385
 .
 40667
 0.17
chr1_17871786_17871970 0.17 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 5548
 0.27
chr9_101706823_101707024 0.17 RP11-92C4.6
866
 0.45
chr10_33425320_33425471 0.17 ENSG00000263576
 .
 37831
 0.16
chr2_203881741_203882170 0.17 NBEAL1
 neurobeachin-like 1
 2353
 0.35
chr2_101358636_101358796 0.17 NPAS2
 neuronal PAS domain protein 2
 77898
 0.09
chr4_26347299_26347489 0.17 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 2632
 0.42
chr3_73652541_73652692 0.17 ENSG00000239119
 .
 9463
 0.21
chr13_52132399_52132573 0.17 ENSG00000266611
 .
 5761
 0.14
chr1_173835540_173835691 0.17 ENSG00000234741
 .
 106
 0.88
chr9_90812890_90813286 0.17 ENSG00000252299
 .
 176096
 0.03
chr4_122616322_122616745 0.17 ANXA5
 annexin A5
 1584
 0.45
chr8_96714886_96715046 0.17 ENSG00000223297
 .
 23823
 0.26
chr2_190041307_190041749 0.17 COL5A2
 collagen, type V, alpha 2
 3077
 0.31
chr1_51726454_51726959 0.17 RP11-296A18.6
5040
 0.16
chr1_55865474_55865625 0.17 ENSG00000252162
 .
 1362
 0.5
chr13_50645613_50645841 0.17 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
 10580
 0.16
chr12_91487813_91488090 0.17 LUM
 lumican
 17657
 0.21
chr9_99265347_99265498 0.17 HABP4
 hyaluronan binding protein 4
 52935
 0.13
chr6_157270459_157270621 0.17 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 48033
 0.19
chr2_142888867_142889088 0.17 LRP1B
 low density lipoprotein receptor-related protein 1B
 293
 0.93
chr7_72933105_72933537 0.17 BAZ1B
 bromodomain adjacent to zinc finger domain, 1B
 3281
 0.19
chr10_34630198_34630349 0.17 PARD3
 par-3 family cell polarity regulator
 31188
 0.25
chr13_33778212_33778569 0.17 STARD13
 StAR-related lipid transfer (START) domain containing 13
 1753
 0.42
chr9_124498552_124498751 0.17 DAB2IP
 DAB2 interacting protein
 6413
 0.28
chr14_100345979_100346191 0.17 EML1
 echinoderm microtubule associated protein like 1
 14139
 0.22
chr2_64633040_64633281 0.17 AC008074.3
47772
 0.13
chr4_142423380_142423531 0.17 IL15
 interleukin 15
 134297
 0.05
chr7_130623665_130623952 0.16 LINC-PINT
 long intergenic non-protein coding RNA, p53 induced transcript
 45060
 0.16
chr20_32149890_32150174 0.16 CBFA2T2
 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
 108
 0.97
chr7_94027821_94027972 0.16 COL1A2
 collagen, type I, alpha 2
 4023
 0.33
chr15_96855709_96855975 0.16 NR2F2-AS1
 NR2F2 antisense RNA 1
 10032
 0.16
chr15_37179413_37179956 0.16 ENSG00000212511
 .
 34843
 0.22
chr17_36600608_36600759 0.16 ENSG00000260833
 .
 7249
 0.16
chr4_87518747_87518898 0.16 PTPN13
 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
 1976
 0.35
chr3_149266255_149266548 0.16 ENSG00000252581
 .
 22983
 0.17
chr17_57505253_57505417 0.16 RP11-567L7.5
24671
 0.18
chrX_37730532_37730793 0.16 ENSG00000206983
 .
 1300
 0.5
chr1_198791306_198791457 0.16 ENSG00000207975
 .
 36730
 0.18
chr17_53809217_53809377 0.16 TMEM100
 transmembrane protein 100
 185
 0.96
chr1_172320901_172321057 0.16 ENSG00000252354
 .
 3696
 0.22
chr9_16871555_16871924 0.16 BNC2
 basonuclin 2
 898
 0.74
chr22_33198587_33198826 0.16 TIMP3
 TIMP metallopeptidase inhibitor 3
 1019
 0.61
chr8_25901085_25901478 0.16 EBF2
 early B-cell factor 2
 1632
 0.53
chr16_50241915_50242069 0.16 ADCY7
 adenylate cyclase 7
 38056
 0.13
chr1_87583813_87583964 0.16 ENSG00000221222
 .
 33093
 0.21
chr1_202509205_202509449 0.16 ENSG00000253042
 .
 12772
 0.21
chr15_66795614_66795765 0.16 ENSG00000200623
 .
 37
 0.82
chr14_45559122_45559273 0.16 ENSG00000212615
 .
 1751
 0.24
chr11_65202266_65202417 0.16 ENSG00000245532
 .
 9588
 0.12

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of TBX19

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.3 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.2 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.1 0.2 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.2 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.2 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.1 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.2 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0009158 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.2 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.1 GO:0022030 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.0 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.0 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0090037 regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.1 GO:0072283 mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003337) metanephric renal vesicle morphogenesis(GO:0072283)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.2 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 0.0 GO:2000050 regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.1 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.0 0.1 GO:0043113 receptor clustering(GO:0043113)
0.0 0.1 GO:1903020 positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.1 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.0 GO:0031223 auditory behavior(GO:0031223)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.0 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.0 GO:0031659 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.1 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0 0.1 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.0 GO:0071680 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0 0.2 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.0 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.0 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.0 GO:0048840 otolith development(GO:0048840)
0.0 0.0 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.0 GO:0060872 semicircular canal development(GO:0060872)
0.0 0.0 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.0 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.0 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.1 GO:1901862 negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
0.0 0.0 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.0 0.2 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.0 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.0 GO:0060057 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.0 GO:0061004 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0 0.0 GO:0010815 bradykinin catabolic process(GO:0010815)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043218 compact myelin(GO:0043218)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.3 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0044291 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 1.1 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.0 GO:0032059 bleb(GO:0032059)
0.0 0.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0031430 M band(GO:0031430)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.3 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.0 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.0 GO:0046980 tapasin binding(GO:0046980)
0.0 0.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.0 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.0 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.0 GO:0035514 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.0 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0030553 cGMP binding(GO:0030553)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.1 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.0 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.0 REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX Genes involved in Signaling by TGF-beta Receptor Complex
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.1 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.0 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors