Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TCF21

Z-value: 1.14

Motif logo

Transcription factors associated with TCF21

Gene Symbol	Gene ID	Gene Info
TCF21 Ensembl NCBI GeneCards UniProt	ENSG00000118526.6	TCF21

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
TCF21	chr6_134210706_134210991	375	0.698482	-0.31	4.2e-01	Click!
TCF21	chr6_134210535_134210686	137	0.830676	-0.29	4.5e-01	Click!
TCF21	chr6_134211072_134211606	866	0.502462	0.21	5.8e-01	Click!
TCF21	chr6_134210328_134210483	68	0.757923	0.09	8.1e-01	Click!

Activity of the TCF21 motif across conditions

Conditions sorted by the z-value of the TCF21 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_145276293_145276624	0.58	ZEB2-AS1	ZEB2 antisense RNA 1	434	0.52
chr6_159465378_159465638	0.50	TAGAP	T-cell activation RhoGTPase activating protein	542	0.78
chr20_31351724_31351875	0.47	DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	1351	0.43
chr19_15580169_15580596	0.44	RASAL3	RAS protein activator like 3	5000	0.14
chr12_8862062_8862268	0.38	RIMKLB	ribosomal modification protein rimK-like family member B	9723	0.17
chr20_52464106_52464266	0.38	AC005220.3		92513	0.08
chr8_8610679_8610830	0.37	CLDN23	claudin 23	51306	0.15
chr12_57828470_57828621	0.37	INHBC	inhibin, beta C	2	0.95
chr15_57508769_57508920	0.35	TCF12	transcription factor 12	2784	0.37
chr8_125617266_125617519	0.35	RP11-532M24.1		25520	0.16
chr7_64349557_64349866	0.35	RP11-797H7.5		767	0.67
chr12_9142516_9142764	0.34	KLRG1	killer cell lectin-like receptor subfamily G, member 1	423	0.81
chr18_22811215_22811414	0.33	ZNF521	zinc finger protein 521	180	0.97
chr14_75801139_75801383	0.33	FOS	FBJ murine osteosarcoma viral oncogene homolog	54365	0.1
chr1_245215310_245215673	0.33	ENSG00000251754	.	8261	0.17
chr19_16427219_16427370	0.32	CTD-2562J15.6		8031	0.16
chr21_46970159_46970310	0.32	SLC19A1	solute carrier family 19 (folate transporter), member 1	5909	0.24
chr11_1874347_1875032	0.31	LSP1	lymphocyte-specific protein 1	489	0.65
chr10_54514994_54515145	0.31	RP11-556E13.1		100	0.98
chr1_114483508_114483659	0.31	HIPK1	homeodomain interacting protein kinase 1	10184	0.13
chr4_82426507_82426753	0.31	RASGEF1B	RasGEF domain family, member 1B	33561	0.24
chr8_41623788_41623939	0.30	ANK1	ankyrin 1, erythrocytic	31277	0.15
chr11_64512499_64513555	0.30	RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	99	0.95
chr3_184869954_184870148	0.29	C3orf70	chromosome 3 open reading frame 70	751	0.7
chr17_68166046_68166268	0.29	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	481	0.55
chr21_44524771_44524948	0.29	U2AF1	U2 small nuclear RNA auxiliary factor 1	503	0.75
chr1_109204500_109204651	0.29	HENMT1	HEN1 methyltransferase homolog 1 (Arabidopsis)	427	0.83
chr17_143001_143152	0.29	RP11-1260E13.1		28107	0.13
chr13_78493097_78493683	0.29	EDNRB	endothelin receptor type B	424	0.48
chr1_245018870_245019021	0.29	HNRNPU-AS1	HNRNPU antisense RNA 1	146	0.95
chr1_184121550_184121895	0.29	ENSG00000199840	.	19235	0.25
chr7_50357605_50357756	0.28	IKZF1	IKAROS family zinc finger 1 (Ikaros)	9362	0.29
chr1_59782411_59782670	0.28	FGGY	FGGY carbohydrate kinase domain containing	6781	0.34
chr11_67778123_67778316	0.28	ALDH3B1	aldehyde dehydrogenase 3 family, member B1	429	0.73
chr4_128553582_128553997	0.28	INTU	inturned planar cell polarity protein	298	0.94
chr6_158622105_158622256	0.28	ENSG00000265803	.	26164	0.16
chr12_117036919_117037510	0.28	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	23558	0.24
chr5_90478735_90478954	0.28	ENSG00000199643	.	87700	0.1
chr12_56138916_56139328	0.28	GDF11	growth differentiation factor 11	1939	0.16
chr4_76822812_76822963	0.27	PPEF2	protein phosphatase, EF-hand calcium binding domain 2	794	0.58
chr5_17144956_17145201	0.27	ENSG00000251990	.	12102	0.2
chr17_40283670_40283821	0.27	RAB5C	RAB5C, member RAS oncogene family	2968	0.13
chr21_34443663_34444086	0.27	AP000282.2		464	0.55
chr15_59978021_59978291	0.27	RP11-361D15.2		2560	0.21
chr1_154171748_154172121	0.27	TPM3	tropomyosin 3	4810	0.1
chr5_50007615_50007766	0.26	PARP8	poly (ADP-ribose) polymerase family, member 8	44299	0.21
chr6_31555088_31555348	0.26	LST1	leukocyte specific transcript 1	125	0.86
chr2_101841003_101841154	0.26	CNOT11	CCR4-NOT transcription complex, subunit 11	28186	0.16
chr21_34185899_34186080	0.26	C21orf62	chromosome 21 open reading frame 62	0	0.97
chr15_48909824_48909975	0.26	FBN1	fibrillin 1	28019	0.23
chr7_148330575_148330726	0.26	C7orf33	chromosome 7 open reading frame 33	42993	0.14
chr3_150995962_150996155	0.26	P2RY14	purinergic receptor P2Y, G-protein coupled, 14	99	0.97
chr14_91111245_91111396	0.26	TTC7B	tetratricopeptide repeat domain 7B	768	0.6
chr4_153459378_153459529	0.26	ENSG00000268471	.	1873	0.31
chr9_71174970_71175121	0.25	TMEM252	transmembrane protein 252	19262	0.25
chr6_133068019_133068170	0.25	RP1-55C23.7		5720	0.13
chr9_6913439_6913590	0.25	RP11-403H13.1		10844	0.24
chr14_23288815_23289060	0.25	SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	7	0.95
chr6_136791083_136791234	0.25	MAP7	microtubule-associated protein 7	3145	0.32
chr6_46376004_46376155	0.25	RCAN2	regulator of calcineurin 2	48634	0.16
chr20_52703439_52703654	0.24	BCAS1	breast carcinoma amplified sequence 1	16242	0.21
chr1_160681036_160681588	0.24	CD48	CD48 molecule	281	0.89
chr11_32460808_32460959	0.24	WT1-AS	WT1 antisense RNA	967	0.61
chr4_15418160_15418311	0.24	RP11-484O2.1		3421	0.22
chrX_131624482_131624759	0.24	MBNL3	muscleblind-like splicing regulator 3	624	0.83
chr12_14796282_14796433	0.24	RP11-174G6.1		22232	0.16
chr2_115918703_115918854	0.24	DPP10-AS1	DPP10 antisense RNA 1	10	0.88
chr12_123752691_123752842	0.24	CDK2AP1	cyclin-dependent kinase 2 associated protein 1	65	0.95
chr17_61778306_61778706	0.24	LIMD2	LIM domain containing 2	26	0.97
chr11_8228040_8228278	0.24	RIC3	RIC3 acetylcholine receptor chaperone	37557	0.16
chr7_55601634_55601785	0.24	VOPP1	vesicular, overexpressed in cancer, prosurvival protein 1	3678	0.29
chr5_123392522_123392673	0.24	CSNK1G3	casein kinase 1, gamma 3	468478	0.01
chr3_23804583_23804865	0.24	ENSG00000238672	.	4378	0.25
chr1_108593520_108593821	0.24	ENSG00000264753	.	32277	0.19
chr7_88025228_88025379	0.24	ENSG00000207094	.	53243	0.15
chr10_92690511_92690662	0.24	ENSG00000201604	.	7994	0.19
chr15_86126252_86126683	0.23	RP11-815J21.2		3058	0.23
chr1_211500199_211501024	0.23	TRAF5	TNF receptor-associated factor 5	432	0.87
chr1_234910955_234911218	0.23	ENSG00000201638	.	62634	0.13
chr11_128588908_128589084	0.23	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	23078	0.17
chr9_13787686_13787970	0.23	NFIB	nuclear factor I/B	392963	0.01
chr2_127417167_127417318	0.23	GYPC	glycophorin C (Gerbich blood group)	3482	0.34
chr2_168438647_168438800	0.23	ENSG00000238357	.	49328	0.19
chr5_35781420_35781571	0.23	SPEF2	sperm flagellar 2	2225	0.36
chr17_66596046_66596347	0.23	FAM20A	family with sequence similarity 20, member A	1334	0.52
chr6_24919733_24919934	0.23	FAM65B	family with sequence similarity 65, member B	8638	0.23
chr12_75875877_75876340	0.23	GLIPR1	GLI pathogenesis-related 1	1124	0.49
chr2_174890200_174890425	0.23	SP3	Sp3 transcription factor	59882	0.15
chr11_35144138_35144289	0.23	AL356215.1		6002	0.19
chr15_63524002_63524153	0.23	RAB8B	RAB8B, member RAS oncogene family	42272	0.14
chr5_137691113_137691264	0.23	KDM3B	lysine (K)-specific demethylase 3B	2903	0.18
chr3_107821041_107821248	0.23	CD47	CD47 molecule	11272	0.29
chr17_3865236_3865510	0.23	ATP2A3	ATPase, Ca++ transporting, ubiquitous	2212	0.29
chr10_112357348_112357499	0.23	ENSG00000239125	.	21305	0.14
chr11_123229225_123229659	0.23	ENSG00000265357	.	22778	0.2
chr2_43455773_43455924	0.23	AC010883.5		864	0.61
chr5_95066383_95066820	0.23	RHOBTB3	Rho-related BTB domain containing 3	25	0.96
chr11_118110290_118110538	0.23	MPZL3	myelin protein zero-like 3	12648	0.13
chr13_24210772_24210935	0.23	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	57334	0.14
chr1_31460456_31460607	0.23	PUM1	pumilio RNA-binding family member 1	7375	0.18
chr16_23161362_23161529	0.22	USP31	ubiquitin specific peptidase 31	854	0.66
chr12_121677598_121677871	0.22	CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	20611	0.16
chr1_110159560_110159711	0.22	AMPD2	adenosine monophosphate deaminase 2	909	0.36
chr1_151592946_151593154	0.22	RP11-404E16.1		7211	0.11
chr17_38604215_38604366	0.22	IGFBP4	insulin-like growth factor binding protein 4	4577	0.16
chr19_12889048_12889583	0.22	HOOK2	hook microtubule-tethering protein 2	44	0.92
chr2_74804644_74804826	0.22	LOXL3	lysyl oxidase-like 3	21918	0.09
chr2_60638627_60638831	0.22	ENSG00000266078	.	24149	0.2
chr11_118085317_118085565	0.22	AMICA1	adhesion molecule, interacts with CXADR antigen 1	165	0.94
chrX_128914480_128914899	0.22	SASH3	SAM and SH3 domain containing 3	729	0.68
chr12_111618967_111619231	0.22	CUX2	cut-like homeobox 2	81849	0.09
chr9_93564472_93565060	0.22	SYK	spleen tyrosine kinase	557	0.87
chr3_105295301_105295452	0.22	ALCAM	activated leukocyte cell adhesion molecule	42930	0.21
chr10_130832704_130832855	0.22	MGMT	O-6-methylguanine-DNA methyltransferase	432669	0.01
chr1_212325647_212325798	0.22	ENSG00000252879	.	52704	0.12
chr18_56245541_56245920	0.22	RP11-126O1.2		21428	0.14
chr14_35179286_35179550	0.22	CFL2	cofilin 2 (muscle)	3616	0.25
chr14_88474301_88474452	0.22	GPR65	G protein-coupled receptor 65	2908	0.23
chr5_141872256_141872598	0.22	ENSG00000252831	.	41483	0.18
chr8_120650260_120650433	0.22	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	674	0.78
chr11_122536513_122536664	0.21	UBASH3B	ubiquitin associated and SH3 domain containing B	10205	0.24
chr2_238598166_238598563	0.21	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	2424	0.34
chr6_32920569_32920784	0.21	HLA-DMA	major histocompatibility complex, class II, DM alpha	162	0.56
chr2_40907638_40908036	0.21	SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	69644	0.14
chr11_42107655_42107806	0.21	LRRC4C	leucine rich repeat containing 4C	626407	0.0
chr10_94515647_94515798	0.21	ENSG00000201412	.	45357	0.14
chr18_66505598_66505749	0.21	CCDC102B	coiled-coil domain containing 102B	1672	0.41
chr8_116675050_116675578	0.21	TRPS1	trichorhinophalangeal syndrome I	1409	0.6
chr15_69695885_69696036	0.21	ENSG00000207395	.	2820	0.17
chr4_87050749_87050921	0.21	RP11-778J15.1		9968	0.23
chr8_74283083_74283286	0.21	RP11-434I12.2		14488	0.25
chr9_139423244_139423395	0.21	ENSG00000263403	.	9241	0.09
chr18_9083293_9083444	0.21	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	19260	0.17
chr8_117163981_117164132	0.21	ENSG00000221793	.	15058	0.29
chr15_63524568_63524719	0.21	RAB8B	RAB8B, member RAS oncogene family	42838	0.14
chr13_103423092_103423243	0.21	TEX30	testis expressed 30	17	0.96
chr2_74264500_74264778	0.21	TET3	tet methylcytosine dioxygenase 3	8811	0.18
chr11_63319075_63319226	0.21	HRASLS2	HRAS-like suppressor 2	11705	0.14
chr15_63795725_63795911	0.21	USP3	ubiquitin specific peptidase 3	975	0.63
chr10_26778557_26778708	0.21	ENSG00000199733	.	19886	0.24
chr2_233949302_233949453	0.21	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	24188	0.17
chr9_83728640_83728791	0.21	ENSG00000221581	.	379471	0.01
chr18_52519559_52519845	0.21	RAB27B	RAB27B, member RAS oncogene family	24272	0.21
chr13_77899686_77900769	0.21	MYCBP2	MYC binding protein 2, E3 ubiquitin protein ligase	587	0.85
chr18_52495652_52496658	0.21	RAB27B	RAB27B, member RAS oncogene family	725	0.77
chr2_118773318_118773469	0.21	ENSG00000243510	.	565	0.64
chr13_99195550_99195827	0.21	STK24	serine/threonine kinase 24	21436	0.2
chr7_138293225_138293376	0.21	ENSG00000252188	.	16624	0.23
chr21_46573190_46573341	0.21	ADARB1	adenosine deaminase, RNA-specific, B1	18292	0.17
chr8_1904836_1904987	0.21	KBTBD11	kelch repeat and BTB (POZ) domain containing 11	17133	0.24
chr4_53017131_53017386	0.21	SPATA18	spermatogenesis associated 18	99676	0.08
chr3_133661654_133661805	0.21	C3orf36	chromosome 3 open reading frame 36	13073	0.23
chr8_23997445_23997596	0.20	ENSG00000207201	.	62849	0.14
chr17_45334525_45334676	0.20	ENSG00000238419	.	2186	0.21
chr6_13273500_13273733	0.20	PHACTR1	phosphatase and actin regulator 1	627	0.46
chr6_107021251_107021402	0.20	AIM1	absent in melanoma 1	32297	0.14
chr19_42260620_42260771	0.20	CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	1366	0.33
chr9_134150260_134150411	0.20	FAM78A	family with sequence similarity 78, member A	1599	0.36
chr21_36612358_36612509	0.20	RUNX1	runt-related transcription factor 1	190792	0.03
chr8_23366659_23366810	0.20	SLC25A37	solute carrier family 25 (mitochondrial iron transporter), member 37	19584	0.16
chr3_9004693_9005124	0.20	RAD18	RAD18 homolog (S. cerevisiae)	278	0.92
chr1_167619596_167619862	0.20	RP3-455J7.4		19818	0.18
chr3_151963057_151963208	0.20	MBNL1	muscleblind-like splicing regulator 1	22697	0.21
chr3_15313694_15313943	0.20	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	3598	0.18
chr4_120291951_120292186	0.20	ENSG00000201186	.	3351	0.26
chr18_9113256_9113407	0.20	RP11-143J12.3		2544	0.24
chr8_121822100_121822251	0.20	SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	2208	0.3
chr6_110555384_110555535	0.20	CDC40	cell division cycle 40	53835	0.13
chr3_18487175_18487565	0.20	SATB1	SATB homeobox 1	290	0.75
chr2_233948085_233948236	0.20	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	22971	0.18
chr2_172877202_172877353	0.20	METAP1D	methionyl aminopeptidase type 1D (mitochondrial)	12787	0.23
chr1_8761101_8761375	0.20	RERE	arginine-glutamic acid dipeptide (RE) repeats	2040	0.41
chr6_75877058_75877209	0.20	COL12A1	collagen, type XII, alpha 1	15228	0.25
chr12_76413840_76414001	0.20	RP11-290L1.3		10354	0.19
chr1_246945751_246945958	0.20	ENSG00000227953	.	6460	0.17
chrX_118407364_118407689	0.20	PGRMC1	progesterone receptor membrane component 1	37238	0.17
chr9_6959941_6960092	0.20	KDM4C	lysine (K)-specific demethylase 4C	34515	0.21
chr7_131240036_131240570	0.20	PODXL	podocalyxin-like	1063	0.65
chr8_97523748_97523899	0.20	SDC2	syndecan 2	17587	0.25
chr17_48218383_48218580	0.20	AC002401.1		5530	0.1
chr13_33752733_33752884	0.20	STARD13	StAR-related lipid transfer (START) domain containing 13	7408	0.23
chr5_142381326_142381532	0.20	ARHGAP26	Rho GTPase activating protein 26	35332	0.22
chr9_81972295_81972446	0.20	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	214318	0.03
chr1_150972321_150972472	0.20	FAM63A	family with sequence similarity 63, member A	1750	0.17
chr3_184893391_184893626	0.20	EHHADH-AS1	EHHADH antisense RNA 1	12819	0.2
chr4_65504939_65505090	0.19	TECRL	trans-2,3-enoyl-CoA reductase-like	229828	0.02
chr4_6927460_6927611	0.19	TBC1D14	TBC1 domain family, member 14	15560	0.16
chr5_156540231_156540382	0.19	HAVCR2	hepatitis A virus cellular receptor 2	3581	0.17
chr1_66868301_66868452	0.19	PDE4B	phosphodiesterase 4B, cAMP-specific	48311	0.18
chr18_53254177_53254364	0.19	TCF4	transcription factor 4	77	0.98
chr2_207938706_207938857	0.19	ENSG00000253008	.	36016	0.16
chr6_112960793_112960944	0.19	ENSG00000252215	.	107484	0.07
chr13_114064294_114064563	0.19	ADPRHL1	ADP-ribosylhydrolase like 1	39029	0.11
chr2_101478838_101478989	0.19	AC092168.2		39790	0.16
chr10_88170804_88170968	0.19	GRID1	glutamate receptor, ionotropic, delta 1	44651	0.14
chr12_123713655_123713840	0.19	MPHOSPH9	M-phase phosphoprotein 9	1246	0.35
chr20_10457057_10457208	0.19	SLX4IP	SLX4 interacting protein	41181	0.16
chr18_60605343_60605494	0.19	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	35035	0.2
chr1_162469519_162469670	0.19	UHMK1	U2AF homology motif (UHM) kinase 1	1961	0.33
chr12_10876110_10876483	0.19	YBX3	Y box binding protein 3	385	0.85

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF21

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.1	0.2	GO:0070672	response to interleukin-15(GO:0070672)
0.1	0.2	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.1	0.2	GO:0014041	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.1	0.2	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.2	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.1	0.2	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.1	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.3	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.0	0.3	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0071224	cellular response to peptidoglycan(GO:0071224)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0032661	interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0	0.2	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.2	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.2	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.2	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.2	GO:0070339	response to bacterial lipoprotein(GO:0032493) response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.2	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.3	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0051458	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.2	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.2	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.2	GO:0010830	regulation of myotube differentiation(GO:0010830)
0.0	0.2	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.1	GO:0001878	response to yeast(GO:0001878)
0.0	0.0	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0001714	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.2	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.0	GO:1903670	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.0	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.0	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.2	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.2	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.2	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.1	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.1	GO:0016093	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0002068	glandular epithelial cell development(GO:0002068)
0.0	0.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0060058	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0015811	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.1	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0006824	cobalt ion transport(GO:0006824)
0.0	0.0	GO:0014805	smooth muscle adaptation(GO:0014805)
0.0	0.1	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.0	GO:0007501	mesodermal cell fate specification(GO:0007501)
0.0	0.1	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.0	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.0	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.2	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.1	GO:0045830	positive regulation of isotype switching(GO:0045830)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.1	GO:0072131	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.0	GO:0002246	wound healing involved in inflammatory response(GO:0002246) connective tissue replacement involved in inflammatory response wound healing(GO:0002248) inflammatory response to wounding(GO:0090594) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.0	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0010829	negative regulation of glucose transport(GO:0010829)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.0	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.0	0.0	GO:0033025	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.1	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.0	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.1	GO:0034505	tooth mineralization(GO:0034505)
0.0	0.2	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0	0.0	GO:0045354	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0	0.0	GO:0042819	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:0071320	cellular response to cAMP(GO:0071320)
0.0	0.0	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.0	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.0	GO:0060206	estrous cycle phase(GO:0060206)
0.0	0.0	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0043267	negative regulation of potassium ion transport(GO:0043267)
0.0	0.1	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.0	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.0	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.0	GO:0060751	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.0	GO:0032691	negative regulation of interleukin-1 beta production(GO:0032691) negative regulation of interleukin-1 production(GO:0032692)
0.0	0.0	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0006534	cysteine metabolic process(GO:0006534)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.1	GO:0043388	positive regulation of DNA binding(GO:0043388)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.0	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.2	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.1	GO:0060004	reflex(GO:0060004)
0.0	0.1	GO:0006853	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.1	GO:0016075	rRNA catabolic process(GO:0016075)
0.0	0.0	GO:0052167	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.0	GO:0060291	long-term synaptic potentiation(GO:0060291)
0.0	0.0	GO:0043570	maintenance of DNA repeat elements(GO:0043570)
0.0	0.0	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0006998	nuclear envelope organization(GO:0006998)
0.0	0.0	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.1	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.0	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
0.0	0.0	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0070695	FHF complex(GO:0070695)
0.1	GO:0048179	activin receptor complex(GO:0048179)
0.1	GO:0032009	early phagosome(GO:0032009)
0.4	GO:0031528	microvillus membrane(GO:0031528)
0.2	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.2	GO:0001527	microfibril(GO:0001527)
0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	GO:0030312	external encapsulating structure(GO:0030312)
0.2	GO:0042589	zymogen granule membrane(GO:0042589)
0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.2	GO:0000145	exocyst(GO:0000145)
0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.1	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.1	GO:0042629	mast cell granule(GO:0042629)
0.1	GO:0030904	retromer complex(GO:0030904)
0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1	GO:0005869	dynactin complex(GO:0005869)
0.1	GO:0043218	compact myelin(GO:0043218)
0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0000800	lateral element(GO:0000800)
0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.3	GO:0005720	nuclear heterochromatin(GO:0005720)
0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	GO:0033270	paranode region of axon(GO:0033270)
0.2	GO:0045495	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0	GO:0033185	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.1	GO:0000421	autophagosome membrane(GO:0000421)
0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	GO:0030008	TRAPP complex(GO:0030008)
0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	GO:0002142	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.3	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.1	0.2	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.2	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.2	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.2	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.2	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.2	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.2	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.3	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.0	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.2	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.0	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.3	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.0	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.1	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.2	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.1	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0004000	adenosine deaminase activity(GO:0004000)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.0	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.0	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.2	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.2	GO:0010181	FMN binding(GO:0010181)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.0	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.0	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.0	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.0	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.3	GO:0003823	antigen binding(GO:0003823)
0.0	0.0	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.2	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.0	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.2	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.0	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.3	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0008035	high-density lipoprotein particle binding(GO:0008035)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.4	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.0	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.3	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	0.1	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.1	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	0.5	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.1	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.2	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.2	PID S1P S1P3 PATHWAY	S1P3 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	REACTOME PI3K CASCADE	Genes involved in PI3K Cascade
0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.4	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.7	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling
0.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.3	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	REACTOME PLATELET HOMEOSTASIS	Genes involved in Platelet homeostasis
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1	REACTOME SHC RELATED EVENTS	Genes involved in SHC-related events
0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.7	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.0	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.3	REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS	Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events
0.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR