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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TFAP2E

Z-value: 0.50

Motif logo

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
ENSG00000116819.6 TFAP2E

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
TFAP2Echr1_36038362_360385135340.574435-0.206.1e-01Click!
TFAP2Echr1_36038675_36039393630.797400-0.206.1e-01Click!

Activity of the TFAP2E motif across conditions

Conditions sorted by the z-value of the TFAP2E motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr2_153406166_153406317 0.23 FMNL2
formin-like 2
69851
0.13
chr8_57594130_57594603 0.16 RP11-17A4.2

192709
0.03
chr9_35489468_35490886 0.15 RUSC2
RUN and SH3 domain containing 2
53
0.97
chr3_192549660_192549811 0.14 FGF12
fibroblast growth factor 12
64182
0.13
chr11_119189616_119189883 0.14 MCAM
melanoma cell adhesion molecule
1923
0.17
chr5_34710476_34710647 0.14 RAI14
retinoic acid induced 14
22897
0.22
chr1_201436884_201437966 0.14 PHLDA3
pleckstrin homology-like domain, family A, member 3
887
0.55
chr14_61123462_61124719 0.14 SIX1
SIX homeobox 1
887
0.64
chr1_118644330_118644506 0.13 SPAG17
sperm associated antigen 17
83428
0.1
chr17_19769997_19771171 0.13 ULK2
unc-51 like autophagy activating kinase 2
646
0.74
chr22_46474882_46475506 0.13 FLJ27365
hsa-mir-4763
998
0.36
chr3_49169788_49170138 0.12 LAMB2
laminin, beta 2 (laminin S)
490
0.65
chr9_78589244_78589395 0.12 ENSG00000238826
.
61950
0.14
chr6_133067698_133067849 0.12 RP1-55C23.7

6041
0.13
chr22_22011512_22012681 0.12 KB-1440D3.13

4127
0.1
chrX_39964334_39965624 0.12 BCOR
BCL6 corepressor
8323
0.32
chr9_140500205_140501463 0.11 ARRDC1
arrestin domain containing 1
679
0.56
chr3_50630246_50630397 0.10 HEMK1
HemK methyltransferase family member 1
15766
0.13
chr19_45995836_45996758 0.10 RTN2
reticulon 2
228
0.87
chr8_114450160_114450568 0.10 CSMD3
CUB and Sushi multiple domains 3
1036
0.64
chr3_197044241_197044392 0.09 DLG1
discs, large homolog 1 (Drosophila)
18145
0.15
chr7_116312458_116312799 0.09 MET
met proto-oncogene
169
0.97
chr10_95136415_95136839 0.09 MYOF
myoferlin
105324
0.06
chr15_91285368_91285519 0.09 ENSG00000200677
.
13099
0.14
chr15_51633704_51634417 0.09 GLDN
gliomedin
234
0.91
chr15_91383749_91383900 0.09 CTD-3094K11.1

870
0.48
chr11_74352472_74352623 0.09 POLD3
polymerase (DNA-directed), delta 3, accessory subunit
2888
0.24
chr20_49137876_49138072 0.09 PTPN1
protein tyrosine phosphatase, non-receptor type 1
11054
0.16
chr1_46337821_46337972 0.09 MAST2
microtubule associated serine/threonine kinase 2
41364
0.17
chr2_12842465_12842741 0.09 TRIB2
tribbles pseudokinase 2
14412
0.26
chr13_67597561_67597712 0.08 PCDH9-AS4
PCDH9 antisense RNA 4
32618
0.21
chr7_44923937_44924872 0.08 RP4-673M15.1

148
0.83
chr14_53418107_53419061 0.08 FERMT2
fermitin family member 2
569
0.83
chr22_46067402_46068067 0.08 ATXN10
ataxin 10
55
0.98
chr8_53372834_53372985 0.08 ST18
suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
50544
0.17
chr3_134231000_134231151 0.08 CEP63
centrosomal protein 63kDa
19616
0.18
chr7_128171824_128173030 0.08 RP11-274B21.1

1279
0.43
chr7_152549258_152549409 0.08 ACTR3B
ARP3 actin-related protein 3 homolog B (yeast)
92419
0.08
chr13_51483605_51485004 0.08 RNASEH2B
ribonuclease H2, subunit B
412
0.48
chr6_109288525_109288676 0.08 RP11-787I22.3

31085
0.15
chr4_160127685_160127927 0.08 RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
60227
0.11
chr20_36536600_36536751 0.08 VSTM2L
V-set and transmembrane domain containing 2 like
5131
0.26
chr1_157964729_157965124 0.08 KIRREL
kin of IRRE like (Drosophila)
1491
0.45
chrX_38079311_38080259 0.08 SRPX
sushi-repeat containing protein, X-linked
367
0.75
chr19_11009923_11010074 0.08 CARM1
coactivator-associated arginine methyltransferase 1
20607
0.11
chr5_81701799_81702115 0.08 ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
100791
0.08
chr10_14287036_14287187 0.07 FRMD4A
FERM domain containing 4A
84990
0.09
chr9_33523659_33524999 0.07 ANKRD18B
ankyrin repeat domain 18B
63
0.97
chr1_210465594_210466382 0.07 HHAT
hedgehog acyltransferase
35608
0.17
chr3_12200321_12200529 0.07 TIMP4
TIMP metallopeptidase inhibitor 4
426
0.9
chr1_203254106_203254257 0.07 BTG2
BTG family, member 2
20483
0.15
chr3_11035286_11035437 0.07 SLC6A1
solute carrier family 6 (neurotransmitter transporter), member 1
947
0.65
chr11_111411049_111411648 0.07 LAYN
layilin
36
0.96
chr20_8381155_8381306 0.07 PLCB1-IT1
PLCB1 intronic transcript 1 (non-protein coding)
151858
0.04
chr6_76645073_76645368 0.07 IMPG1
interphotoreceptor matrix proteoglycan 1
454
0.81
chr16_57722748_57722899 0.07 CCDC135
coiled-coil domain containing 135
5882
0.14
chrX_35937822_35938310 0.07 CXorf22
chromosome X open reading frame 22
215
0.96
chr2_102908127_102908384 0.07 IL1RL1
interleukin 1 receptor-like 1
19707
0.18
chr6_140783973_140784124 0.07 ENSG00000221336
.
197802
0.03
chr8_97657180_97658239 0.07 CPQ
carboxypeptidase Q
106
0.98
chr20_49177863_49178105 0.07 ENSG00000201501
.
1562
0.28
chr1_205648469_205649627 0.07 SLC45A3
solute carrier family 45, member 3
539
0.74
chr1_234630809_234631231 0.07 TARBP1
TAR (HIV-1) RNA binding protein 1
16171
0.21
chr16_73098585_73098971 0.07 ZFHX3
zinc finger homeobox 3
5181
0.26
chr1_144708589_144708740 0.07 RP11-640M9.2

93533
0.07
chr14_63904706_63904968 0.06 ENSG00000264995
.
24887
0.16
chr12_114313370_114313521 0.06 RP11-780K2.1

56929
0.15
chr22_46933754_46934840 0.06 CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1
1230
0.46
chr11_131479044_131479195 0.06 NTM
neurotrimin
27214
0.2
chr2_54350719_54350886 0.06 ACYP2
acylphosphatase 2, muscle type
486
0.85
chr10_3598463_3598925 0.06 RP11-184A2.3

194565
0.03
chr12_52400775_52401965 0.06 GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
646
0.62
chr8_15646506_15646657 0.06 TUSC3
tumor suppressor candidate 3
165992
0.04
chr2_201560727_201560878 0.06 AOX1
aldehyde oxidase 1
33172
0.15
chr17_30438687_30438838 0.06 RP11-640N20.9

2382
0.21
chr3_15469035_15469832 0.06 EAF1
ELL associated factor 1
328
0.51
chr17_77019963_77021139 0.06 C1QTNF1
C1q and tumor necrosis factor related protein 1
208
0.91
chr7_45957495_45957807 0.06 IGFBP3
insulin-like growth factor binding protein 3
626
0.73
chr5_115298168_115298999 0.06 AQPEP
Aminopeptidase Q
392
0.86
chr2_45179595_45180280 0.06 SIX3-AS1
SIX3 antisense RNA 1
10925
0.22
chr10_73746466_73746617 0.06 CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
22418
0.22
chr6_5084934_5086227 0.06 PPP1R3G
protein phosphatase 1, regulatory subunit 3G
140
0.97
chrX_65058405_65058556 0.06 RP6-159A1.3

161113
0.04
chr8_77867156_77867509 0.06 ENSG00000266712
.
11754
0.26
chr2_228093116_228093390 0.06 AC097662.2

30661
0.17
chr9_91653559_91653931 0.06 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
3307
0.28
chr16_70470853_70471004 0.06 ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
2063
0.21
chr12_94242498_94242649 0.06 RP11-887P2.6

12630
0.2
chr7_5732198_5732421 0.06 RNF216-IT1
RNF216 intronic transcript 1 (non-protein coding)
12217
0.2
chr3_50328803_50329869 0.06 IFRD2
interferon-related developmental regulator 2
561
0.51
chr2_173420797_173421943 0.06 AC093818.1

46
0.53
chr4_187686525_187686676 0.06 FAT1
FAT atypical cadherin 1
38724
0.2
chr17_1388273_1389008 0.06 MYO1C
myosin IC
21
0.97
chr10_118896343_118896719 0.06 VAX1
ventral anterior homeobox 1
1036
0.51
chr17_60885608_60885921 0.06 MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
59
0.98
chr2_26981186_26981361 0.06 SLC35F6
solute carrier family 35, member F6
5883
0.19
chr3_129323468_129324020 0.06 PLXND1
plexin D1
1917
0.3
chr3_134092531_134092774 0.06 AMOTL2
angiomotin like 2
13
0.98
chr9_100697028_100697179 0.06 HEMGN
hemogen
10035
0.15
chr10_93174739_93174920 0.05 HECTD2
HECT domain containing E3 ubiquitin protein ligase 2
4727
0.35
chr3_64210682_64210890 0.05 PRICKLE2
prickle homolog 2 (Drosophila)
345
0.9
chr5_129353001_129353152 0.05 ENSG00000221562
.
42492
0.18
chrX_124337019_124337170 0.05 ENSG00000263886
.
84531
0.11
chr17_5412555_5412706 0.05 ENSG00000253071
.
4960
0.15
chr1_11072672_11073302 0.05 TARDBP
TAR DNA binding protein
246
0.86
chrX_69674453_69675874 0.05 DLG3
discs, large homolog 3 (Drosophila)
217
0.75
chr15_99434112_99434263 0.05 IGF1R
insulin-like growth factor 1 receptor
617
0.73
chr10_103734168_103734319 0.05 ENSG00000222430
.
21782
0.16
chr2_172266870_172267021 0.05 METTL8
methyltransferase like 8
23555
0.2
chr21_36256728_36257172 0.05 RUNX1
runt-related transcription factor 1
2530
0.42
chr10_15366222_15366373 0.05 FAM171A1
family with sequence similarity 171, member A1
46761
0.17
chr11_121288254_121288502 0.05 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
34534
0.19
chr3_157250943_157251353 0.05 VEPH1
ventricular zone expressed PH domain-containing 1
247
0.94
chr16_54970178_54971110 0.05 IRX5
iroquois homeobox 5
4660
0.36
chr12_122667358_122668232 0.05 LRRC43
leucine rich repeat containing 43
128
0.95
chr12_19018043_19018194 0.05 CAPZA3
capping protein (actin filament) muscle Z-line, alpha 3
127073
0.05
chr16_68676411_68677035 0.05 CDH3
cadherin 3, type 1, P-cadherin (placental)
2016
0.22
chrX_14087477_14087628 0.05 ENSG00000264331
.
6458
0.28
chr3_50120540_50120691 0.05 RBM5
RNA binding motif protein 5
5726
0.16
chr14_24836692_24836908 0.05 NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
92
0.93
chr14_101867418_101867569 0.05 ENSG00000258498
.
159266
0.02
chr5_40384613_40384764 0.05 ENSG00000265615
.
64268
0.14
chr13_99316705_99316856 0.05 ENSG00000243366
.
7454
0.25
chr1_159823893_159825316 0.05 C1orf204
chromosome 1 open reading frame 204
533
0.6
chr22_26930460_26930611 0.05 TPST2
tyrosylprotein sulfotransferase 2
6302
0.14
chr16_48202466_48202617 0.05 RP11-3M1.1

1392
0.45
chr1_92545604_92546569 0.05 BTBD8
BTB (POZ) domain containing 8
9
0.98
chr7_16991756_16991907 0.05 AGR3
anterior gradient 3
70220
0.12
chr17_60248884_60249035 0.05 ENSG00000207123
.
49278
0.14
chr2_121334219_121334381 0.05 ENSG00000201006
.
74549
0.11
chr11_7913917_7914068 0.05 ENSG00000252769
.
3166
0.19
chr14_70346080_70346697 0.05 SMOC1
SPARC related modular calcium binding 1
245
0.95
chr15_67178585_67178736 0.05 SMAD6
SMAD family member 6
174625
0.03
chr17_48278434_48278667 0.05 COL1A1
collagen, type I, alpha 1
443
0.73
chr7_115117728_115117911 0.05 ENSG00000202377
.
103677
0.08
chr1_144983817_144983968 0.05 AL590452.1
Uncharacterized protein
5417
0.16
chr18_72778905_72779056 0.05 ZADH2
zinc binding alcohol dehydrogenase domain containing 2
138488
0.05
chr1_198859885_198860036 0.05 ENSG00000207759
.
31678
0.2
chr15_48937037_48938293 0.05 FBN1
fibrillin 1
253
0.95
chr6_70576415_70577719 0.05 COL19A1
collagen, type XIX, alpha 1
604
0.84
chr20_34043043_34043765 0.05 CEP250
centrosomal protein 250kDa
141
0.87
chr5_179495144_179495436 0.04 RNF130
ring finger protein 130
3431
0.26
chr14_100204692_100204843 0.04 EML1
echinoderm microtubule associated protein like 1
681
0.73
chr16_81534708_81535083 0.04 CMIP
c-Maf inducing protein
5941
0.3
chr16_2077067_2078193 0.04 SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
701
0.35
chr1_206837249_206837437 0.04 ENSG00000252853
.
17965
0.12
chr19_1019836_1021109 0.04 TMEM259
transmembrane protein 259
373
0.62
chr10_123871979_123872182 0.04 TACC2
transforming, acidic coiled-coil containing protein 2
474
0.88
chr10_131506190_131506341 0.04 RP11-109A6.2

6444
0.31
chr1_161277026_161277213 0.04 MPZ
myelin protein zero
142
0.93
chr22_33104594_33104745 0.04 ENSG00000251890
.
73485
0.1
chr10_104536560_104536809 0.04 WBP1L
WW domain binding protein 1-like
678
0.63
chr7_66213885_66214036 0.04 RABGEF1
RAB guanine nucleotide exchange factor (GEF) 1
6916
0.16
chr16_68440843_68441106 0.04 SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
34813
0.11
chr14_101292536_101293492 0.04 AL117190.2

2523
0.08
chr6_16238952_16239854 0.04 GMPR
guanosine monophosphate reductase
592
0.74
chr16_85558280_85558649 0.04 ENSG00000264203
.
83366
0.08
chr3_192568317_192568648 0.04 MB21D2
Mab-21 domain containing 2
67468
0.12
chr14_60952017_60952553 0.04 C14orf39
chromosome 14 open reading frame 39
477
0.82
chr4_145568031_145568374 0.04 HHIP
hedgehog interacting protein
878
0.49
chr14_51835671_51835856 0.04 ENSG00000201820
.
115022
0.05
chr12_1628262_1628523 0.04 WNT5B
wingless-type MMTV integration site family, member 5B
10665
0.24
chr11_126286614_126287132 0.04 ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
10196
0.19
chr17_38336753_38336904 0.04 RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
663
0.6
chr10_15138786_15140121 0.04 RPP38
ribonuclease P/MRP 38kDa subunit
34
0.62
chr7_75830803_75830954 0.04 SRRM3
serine/arginine repetitive matrix 3
338
0.88
chr22_31433016_31433229 0.04 ENSG00000240186
.
22853
0.12
chr12_31868549_31868829 0.04 AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
804
0.56
chr8_146063147_146063298 0.04 ZNF7
zinc finger protein 7
8795
0.11
chr19_13906290_13907522 0.04 ZSWIM4
zinc finger, SWIM-type containing 4
632
0.39
chr15_78799410_78800691 0.04 HYKK
hydroxylysine kinase
91
0.95
chr7_121517277_121517428 0.04 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
3937
0.36
chr5_35852042_35852193 0.04 IL7R
interleukin 7 receptor
680
0.72
chr9_95788170_95788321 0.04 FGD3
FYVE, RhoGEF and PH domain containing 3
10903
0.19
chr1_115753084_115753235 0.04 RP4-663N10.1

72496
0.11
chr19_5036988_5037627 0.04 KDM4B
lysine (K)-specific demethylase 4B
20971
0.2
chr7_134893359_134893623 0.04 WDR91
WD repeat domain 91
2160
0.24
chr1_236958581_236959780 0.04 MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
198
0.96
chr2_9447040_9447191 0.04 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
100221
0.07
chr6_49378033_49378231 0.04 MUT
methylmalonyl CoA mutase
52772
0.12
chr21_44262526_44262677 0.04 WDR4
WD repeat domain 4
37040
0.15
chr9_93881355_93881669 0.04 AUH
AU RNA binding protein/enoyl-CoA hydratase
242665
0.02
chr17_46177753_46179071 0.04 CBX1
chromobox homolog 1
148
0.91
chr6_8433732_8434221 0.04 SLC35B3
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
1740
0.54
chr11_67807279_67808325 0.04 TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
1229
0.3
chr3_128267814_128268156 0.04 C3orf27
chromosome 3 open reading frame 27
26944
0.16
chr17_42071916_42072095 0.04 PYY
peptide YY
9832
0.1
chr19_18716434_18716597 0.04 CRLF1
cytokine receptor-like factor 1
1145
0.26
chr17_72738471_72738622 0.04 RAB37
RAB37, member RAS oncogene family
5175
0.11
chr9_38227227_38227501 0.04 ENSG00000238313
.
36960
0.19
chr19_4712831_4712982 0.04 DPP9
dipeptidyl-peptidase 9
1412
0.29
chr19_8747658_8747869 0.04 ACTL9
actin-like 9
61409
0.09
chr8_85095603_85095799 0.04 RALYL
RALY RNA binding protein-like
68
0.99
chr4_99830188_99830339 0.04 RP11-571L19.7

19785
0.15
chr14_101004037_101004188 0.04 BEGAIN
brain-enriched guanylate kinase-associated
10323
0.14
chr13_32623224_32623468 0.04 FRY
furry homolog (Drosophila)
11655
0.23
chr6_122931066_122932065 0.04 PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
188
0.97
chr5_159340244_159340395 0.04 ADRA1B
adrenoceptor alpha 1B
3471
0.33
chr1_212810509_212810859 0.04 RP11-338C15.5

10571
0.14
chr17_16190496_16190647 0.04 ENSG00000221355
.
5243
0.2

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of TFAP2E

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.0 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0090036 regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0050667 homocysteine metabolic process(GO:0050667)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.0 GO:0001940 male pronucleus(GO:0001940)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.0 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.0 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.0 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)