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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for TFAP4_MSC

Z-value: 1.43

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Transcription factors associated with TFAP4_MSC

Gene Symbol	Gene ID	Gene Info
TFAP4 Ensembl NCBI GeneCards UniProt	ENSG00000090447.7	transcription factor AP-4
MSC Ensembl NCBI GeneCards UniProt	ENSG00000178860.8	musculin

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr8_72757687_72757838	MSC	1059	0.450921	0.86	2.8e-03	Click!
chr8_72757427_72757578	MSC	799	0.549834	0.82	7.2e-03	Click!
chr8_72776934_72777085	MSC	20306	0.171093	0.79	1.1e-02	Click!
chr8_72766925_72767079	MSC	10299	0.179280	0.79	1.1e-02	Click!
chr8_72770231_72770526	MSC	13675	0.176411	0.78	1.2e-02	Click!
chr16_4313403_4313722	TFAP4	176	0.941979	0.83	6.0e-03	Click!
chr16_4322228_4322788	TFAP4	568	0.721584	-0.65	5.6e-02	Click!
chr16_4343783_4343934	TFAP4	20782	0.124144	0.61	7.8e-02	Click!
chr16_4321404_4321870	TFAP4	1439	0.368757	-0.59	9.2e-02	Click!
chr16_4325240_4325391	TFAP4	2239	0.256901	-0.50	1.7e-01	Click!

Activity of the TFAP4_MSC motif across conditions

Conditions sorted by the z-value of the TFAP4_MSC motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_58148368_58148782	1.29	ENSG00000212017	.	893645	0.0
chr14_102439091_102439415	0.94	DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	8388	0.21
chr15_56207748_56208171	0.90	NEDD4	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	107	0.98
chr2_200852906_200853092	0.89	C2orf47	chromosome 2 open reading frame 47	32455	0.17
chr2_164592268_164592669	0.81	FIGN	fidgetin	49	0.99
chr6_3797715_3797929	0.76	RP11-420L9.4		34345	0.15
chr13_102105024_102105412	0.74	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	200	0.96
chrX_90690422_90690847	0.73	PABPC5-AS1	PABPC5 antisense RNA 1	636	0.54
chr6_152701576_152701930	0.72	SYNE1-AS1	SYNE1 antisense RNA 1	72	0.97
chr13_24145710_24146057	0.72	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	1080	0.66
chr7_33972032_33972255	0.69	BMPER	BMP binding endothelial regulator	26998	0.26
chr3_100711576_100712203	0.68	ABI3BP	ABI family, member 3 (NESH) binding protein	408	0.89
chr5_15502450_15502663	0.68	FBXL7	F-box and leucine-rich repeat protein 7	1009	0.7
chr5_140723404_140723589	0.68	PCDHGA3	protocadherin gamma subfamily A, 3	105	0.89
chr15_73894518_73894871	0.68	NPTN	neuroplastin	30410	0.2
chr11_8830922_8831183	0.67	ST5	suppression of tumorigenicity 5	1144	0.43
chr9_89069552_89069742	0.67	ENSG00000222293	.	31604	0.23
chr3_43662392_43662551	0.65	ANO10	anoctamin 10	918	0.7
chr1_214723042_214723197	0.64	PTPN14	protein tyrosine phosphatase, non-receptor type 14	1447	0.54
chr5_156943785_156944084	0.63	ADAM19	ADAM metallopeptidase domain 19	14104	0.17
chr7_70158668_70158941	0.63	AUTS2	autism susceptibility candidate 2	35321	0.25
chr1_240553613_240553764	0.62	RP11-177F11.1		10735	0.23
chr6_26745930_26746188	0.62	ZNF322	zinc finger protein 322	86079	0.08
chr1_180881914_180882730	0.61	KIAA1614	KIAA1614	3	0.98
chr13_24133308_24133702	0.61	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	11004	0.29
chr8_72273809_72273991	0.61	EYA1	eyes absent homolog 1 (Drosophila)	195	0.97
chr1_214397865_214398571	0.60	SMYD2	SET and MYND domain containing 2	56358	0.16
chr7_101525780_101526170	0.60	CTA-339C12.1		57966	0.12
chr6_52529741_52529892	0.60	RP1-152L7.5		256	0.93
chr15_95847772_95847941	0.60	ENSG00000222076	.	441177	0.01
chr17_46127912_46128198	0.59	NFE2L1	nuclear factor, erythroid 2-like 1	1561	0.2
chr4_55096991_55097208	0.59	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	610	0.82
chr5_2750019_2750705	0.59	IRX2	iroquois homeobox 2	1407	0.43
chr10_125751436_125751814	0.59	CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	54616	0.13
chr12_117036919_117037510	0.59	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	23558	0.24
chr10_35028816_35029027	0.59	PARD3	par-3 family cell polarity regulator	75328	0.11
chr5_39422660_39422883	0.58	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	2199	0.42
chr8_94713195_94713677	0.58	FAM92A1	family with sequence similarity 92, member A1	326	0.7
chr12_95594214_95594457	0.57	FGD6	FYVE, RhoGEF and PH domain containing 6	16820	0.18
chr19_460012_460518	0.57	SHC2	SHC (Src homology 2 domain containing) transforming protein 2	731	0.5
chr1_153584096_153584410	0.56	S100A16	S100 calcium binding protein A16	1306	0.22
chr2_33359781_33360142	0.56	LTBP1	latent transforming growth factor beta binding protein 1	237	0.96
chr1_170631765_170631991	0.55	PRRX1	paired related homeobox 1	397	0.91
chr18_72509166_72509431	0.55	ZNF407	zinc finger protein 407	166322	0.04
chr9_108009139_108009290	0.55	SLC44A1	solute carrier family 44 (choline transporter), member 1	2311	0.44
chr1_152080538_152081099	0.55	TCHH	trichohyalin	5738	0.15
chr16_121633_122294	0.55	RHBDF1	rhomboid 5 homolog 1 (Drosophila)	666	0.51
chr5_54456050_54456451	0.54	GPX8	glutathione peroxidase 8 (putative)	252	0.86
chr4_110901886_110902148	0.54	ENSG00000207260	.	11464	0.24
chr14_23447268_23447766	0.54	AJUBA	ajuba LIM protein	571	0.5
chr10_29923748_29924013	0.54	SVIL	supervillin	21	0.98
chr7_3300185_3300383	0.54	SDK1	sidekick cell adhesion molecule 1	40796	0.16
chr7_147110177_147110568	0.53	ENSG00000221442	.	35159	0.24
chr11_61485680_61486023	0.53	MYRF	myelin regulatory factor	34270	0.11
chr3_185478386_185478623	0.53	ENSG00000265470	.	7188	0.23
chr1_33808111_33808540	0.52	ENSG00000222112	.	5860	0.13
chr12_59478573_59478971	0.52	RP11-150C16.1		164352	0.04
chr8_25903597_25904111	0.51	EBF2	early B-cell factor 2	941	0.71
chr2_218560010_218560412	0.51	DIRC3	disrupted in renal carcinoma 3	61067	0.14
chr8_99438878_99439083	0.51	KCNS2	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	270	0.92
chr7_23020264_23020554	0.50	FAM126A	family with sequence similarity 126, member A	33284	0.2
chr1_170663513_170663664	0.50	PRRX1	paired related homeobox 1	30510	0.23
chr6_72129322_72130506	0.50	ENSG00000207827	.	16590	0.22
chr6_16741612_16741995	0.50	RP1-151F17.1		19566	0.23
chr22_50744615_50744936	0.50	PLXNB2	plexin B2	1242	0.27
chr12_122667358_122668232	0.50	LRRC43	leucine rich repeat containing 43	128	0.95
chr1_64981979_64982130	0.50	CACHD1	cache domain containing 1	45579	0.17
chr14_59628458_59628668	0.50	DAAM1	dishevelled associated activator of morphogenesis 1	26835	0.26
chr16_83848003_83848154	0.49	HSBP1	heat shock factor binding protein 1	6484	0.17
chr18_59263038_59263245	0.49	CDH20	cadherin 20, type 2	46042	0.2
chr17_59286396_59286547	0.49	RP11-136H19.1		73146	0.1
chr6_53457738_53458227	0.49	GCLC	glutamate-cysteine ligase, catalytic subunit	23786	0.17
chr20_52703439_52703654	0.48	BCAS1	breast carcinoma amplified sequence 1	16242	0.21
chr2_223917307_223917567	0.48	KCNE4	potassium voltage-gated channel, Isk-related family, member 4	575	0.84
chr5_32506491_32506760	0.48	SUB1	SUB1 homolog (S. cerevisiae)	25114	0.21
chr18_74826167_74826436	0.48	MBP	myelin basic protein	9084	0.3
chr9_134278352_134278584	0.48	PRRC2B	proline-rich coiled-coil 2B	8988	0.21
chr22_43076389_43076666	0.48	A4GALT	alpha 1,4-galactosyltransferase	14465	0.14
chr17_76386300_76386478	0.48	ENSG00000200063	.	9627	0.13
chr4_126311427_126311944	0.47	FAT4	FAT atypical cadherin 4	3406	0.33
chr4_154048817_154049154	0.47	TRIM2	tripartite motif containing 2	24660	0.24
chr14_71488181_71488348	0.47	PCNX	pecanex homolog (Drosophila)	8516	0.31
chr4_80572253_80572434	0.47	OR7E94P	olfactory receptor, family 7, subfamily E, member 94 pseudogene	63059	0.15
chr17_59093245_59093641	0.47	RP11-264B14.1		54040	0.1
chr2_199000441_199000592	0.46	PLCL1	phospholipase C-like 1	51980	0.18
chr20_13010458_13010653	0.46	SPTLC3	serine palmitoyltransferase, long chain base subunit 3	20558	0.28
chr2_237654651_237654995	0.46	ACKR3	atypical chemokine receptor 3	176539	0.03
chr9_111034250_111034449	0.46	ENSG00000222512	.	86860	0.1
chr16_62068318_62068835	0.46	CDH8	cadherin 8, type 2	462	0.9
chr7_12729767_12729923	0.46	ARL4A	ADP-ribosylation factor-like 4A	2585	0.32
chr6_33557864_33558063	0.45	LINC00336	long intergenic non-protein coding RNA 336	3152	0.17
chr1_164614138_164614289	0.45	ENSG00000207082	.	5411	0.22
chr15_48786194_48786345	0.45	FBN1	fibrillin 1	151649	0.04
chr5_136478740_136479185	0.45	SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	170265	0.04
chr2_95817778_95817929	0.45	ZNF514	zinc finger protein 514	7229	0.18
chr19_41073613_41074217	0.45	SHKBP1	SH3KBP1 binding protein 1	8842	0.14
chr20_3787781_3788040	0.44	CDC25B	cell division cycle 25B	10832	0.11
chr15_41455302_41455599	0.44	ENSG00000240847	.	29013	0.14
chr11_13030522_13031165	0.44	ENSG00000266625	.	45656	0.16
chr12_78336292_78336638	0.44	NAV3	neuron navigator 3	23591	0.28
chr5_38844869_38845152	0.44	OSMR	oncostatin M receptor	950	0.68
chr3_147109765_147110149	0.43	ZIC1	Zic family member 1	1725	0.33
chr14_27245032_27245183	0.43	NOVA1-AS1	NOVA1 antisense RNA 1 (head to head)	6267	0.32
chr5_148121110_148121262	0.43	HTR4	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	75979	0.09
chr3_98609388_98609782	0.43	DCBLD2	discoidin, CUB and LCCL domain containing 2	10430	0.18
chr19_13107353_13108160	0.43	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	1104	0.3
chr8_144681294_144681621	0.43	EEF1D	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	254	0.75
chr8_13132829_13133895	0.42	DLC1	deleted in liver cancer 1	693	0.78
chr13_109895879_109896348	0.42	MYO16-AS1	MYO16 antisense RNA 1	42282	0.21
chr7_93551338_93552000	0.42	GNG11	guanine nucleotide binding protein (G protein), gamma 11	658	0.67
chr2_144281717_144281913	0.42	AC096558.1		43457	0.15
chr5_127980731_127980902	0.42	FBN2	fibrillin 2	14062	0.23
chr6_3912615_3912766	0.41	FAM50B	family with sequence similarity 50, member B	63068	0.1
chr14_52821800_52821992	0.41	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	40783	0.18
chr3_99593001_99593152	0.41	FILIP1L	filamin A interacting protein 1-like	1872	0.43
chr13_67795882_67796033	0.41	PCDH9	protocadherin 9	6615	0.34
chr5_132010802_132011068	0.41	IL4	interleukin 4	1192	0.34
chr6_158182224_158182417	0.41	SNX9	sorting nexin 9	61976	0.12
chr8_1704097_1704340	0.41	CTD-2336O2.1		7245	0.21
chr3_87034608_87034769	0.41	VGLL3	vestigial like 3 (Drosophila)	5164	0.35
chr2_75730443_75730594	0.41	ENSG00000238410	.	13816	0.14
chr7_41736651_41736834	0.41	INHBA-AS1	INHBA antisense RNA 1	3196	0.24
chr7_116312458_116312799	0.40	MET	met proto-oncogene	169	0.97
chrX_118534273_118534424	0.40	SLC25A43	solute carrier family 25, member 43	1005	0.41
chr15_40530958_40531718	0.40	PAK6	p21 protein (Cdc42/Rac)-activated kinase 6	46	0.96
chr16_54968513_54968925	0.40	IRX5	iroquois homeobox 5	2735	0.43
chr10_105610252_105610446	0.40	SH3PXD2A	SH3 and PX domains 2A	4815	0.22
chr8_23656283_23656639	0.40	ENSG00000207027	.	7429	0.2
chr7_139431631_139432085	0.40	HIPK2	homeodomain interacting protein kinase 2	10017	0.26
chr17_76210613_76211139	0.40	BIRC5	baculoviral IAP repeat containing 5	410	0.76
chr1_39598026_39598402	0.40	ENSG00000206654	.	11499	0.17
chr4_128553582_128553997	0.40	INTU	inturned planar cell polarity protein	298	0.94
chr7_27680791_27681081	0.40	HIBADH	3-hydroxyisobutyrate dehydrogenase	6439	0.28
chr17_66596046_66596347	0.39	FAM20A	family with sequence similarity 20, member A	1334	0.52
chr7_1127819_1128160	0.39	GPER1	G protein-coupled estrogen receptor 1	266	0.85
chr8_23711040_23711280	0.39	STC1	stanniocalcin 1	664	0.76
chr8_23260338_23260868	0.39	LOXL2	lysyl oxidase-like 2	986	0.56
chr18_34834231_34834654	0.39	CELF4	CUGBP, Elav-like family member 4	10275	0.2
chr21_38120336_38120723	0.39	SIM2	single-minded family bHLH transcription factor 2	35663	0.15
chr4_181748689_181748884	0.39	NA	NA	> 10⁶	NA
chr15_67228737_67228906	0.39	SMAD3	SMAD family member 3	127280	0.05
chr8_87051491_87051698	0.39	PSKH2	protein serine kinase H2	30332	0.19
chr4_77875681_77875959	0.39	SEPT11	septin 11	4805	0.27
chr4_48604581_48604852	0.39	FRYL	FRY-like	3147	0.3
chr2_9396815_9397226	0.39	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	50126	0.17
chr13_99629297_99629574	0.39	DOCK9	dedicator of cytokinesis 9	809	0.71
chr21_30502885_30503196	0.39	MAP3K7CL	MAP3K7 C-terminal like	81	0.96
chr9_16704821_16704987	0.39	BNC2	basonuclin 2	176	0.96
chr5_141700005_141700156	0.38	SPRY4	sprouty homolog 4 (Drosophila)	3667	0.27
chr6_151325488_151325868	0.38	MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	10338	0.2
chr10_114714851_114715858	0.38	RP11-57H14.2		3720	0.26
chr12_125249339_125249490	0.38	SCARB1	scavenger receptor class B, member 1	52839	0.16
chr5_72934664_72934914	0.38	ARHGEF28	Rho guanine nucleotide exchange factor (GEF) 28	12768	0.2
chr22_36232996_36233711	0.38	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	2912	0.37
chr20_43970794_43971114	0.38	SDC4	syndecan 4	6110	0.13
chr2_46361888_46362039	0.38	AC017006.3		33154	0.2
chr5_36607157_36607629	0.38	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	401	0.91
chr20_45946936_45948261	0.38	AL031666.2	HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852	352	0.82
chr10_104536223_104536534	0.38	WBP1L	WW domain binding protein 1-like	372	0.83
chr16_14595355_14595525	0.38	AC092291.2		30598	0.18
chr20_30300360_30300511	0.38	AL160175.1		8566	0.13
chr15_83952685_83952890	0.38	BNC1	basonuclin 1	679	0.76
chr2_133205944_133206146	0.37	GPR39	G protein-coupled receptor 39	31898	0.17
chr2_227623803_227624269	0.37	IRS1	insulin receptor substrate 1	40439	0.16
chr7_98970111_98970529	0.37	ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	1552	0.28
chr9_18493620_18493893	0.37	ADAMTSL1	ADAMTS-like 1	19525	0.26
chr8_132054499_132054781	0.37	ADCY8	adenylate cyclase 8 (brain)	32	0.99
chr8_97523748_97523899	0.37	SDC2	syndecan 2	17587	0.25
chrX_133681198_133681388	0.37	ENSG00000223749	.	552	0.51
chr3_141405997_141406148	0.37	RNF7	ring finger protein 7	50974	0.14
chr2_36790312_36790466	0.37	AC007401.2	Uncharacterized protein	10978	0.19
chr14_62013944_62014161	0.37	RP11-47I22.1		2047	0.33
chr6_152084748_152085135	0.36	ESR1	estrogen receptor 1	40625	0.17
chr11_63712800_63713200	0.36	NAA40	N(alpha)-acetyltransferase 40, NatD catalytic subunit	6280	0.12
chr12_14569748_14569899	0.36	ATF7IP	activating transcription factor 7 interacting protein	24	0.98
chr9_84764085_84764236	0.36	SPATA31D1	SPATA31 subfamily D, member 1	160473	0.04
chr12_13353569_13354032	0.36	EMP1	epithelial membrane protein 1	4080	0.3
chr5_141700452_141700811	0.36	SPRY4	sprouty homolog 4 (Drosophila)	3116	0.28
chr10_69866394_69866619	0.36	MYPN	myopalladin	594	0.76
chr11_19953228_19953514	0.36	NAV2-AS3	NAV2 antisense RNA 3	49512	0.16
chr6_53875762_53875944	0.36	MLIP	muscular LMNA-interacting protein	7861	0.2
chr6_12573623_12573848	0.36	PHACTR1	phosphatase and actin regulator 1	144158	0.05
chr19_11497917_11498212	0.36	EPOR	erythropoietin receptor	3076	0.1
chr7_41511992_41512216	0.36	INHBA-AS1	INHBA antisense RNA 1	221410	0.02
chr6_9520908_9521095	0.36	OFCC1	orofacial cleft 1 candidate 1	412499	0.01
chr7_42275396_42275690	0.36	GLI3	GLI family zinc finger 3	1069	0.7
chr11_31006065_31006277	0.36	DCDC1	doublecortin domain containing 1	8062	0.32
chr3_157047479_157047630	0.35	ENSG00000243176	.	43605	0.17
chr11_121337447_121337703	0.35	RP11-730K11.1		13853	0.23
chr14_101292536_101293492	0.35	AL117190.2		2523	0.08
chr2_196478039_196478245	0.35	SLC39A10	solute carrier family 39 (zinc transporter), member 10	37441	0.19
chr17_70587270_70588900	0.35	ENSG00000200783	.	72206	0.12
chr20_17850710_17851131	0.35	ENSG00000221220	.	27693	0.16
chr12_13348835_13349296	0.35	EMP1	epithelial membrane protein 1	585	0.82
chr1_46603624_46603795	0.35	RP4-533D7.5		3506	0.18
chr8_1703441_1703788	0.35	CTD-2336O2.1		7849	0.21
chr10_60535442_60535593	0.35	BICC1	bicaudal C homolog 1 (Drosophila)	17778	0.28
chr22_30096458_30096609	0.35	RP1-76B20.12		19170	0.12
chr9_130330127_130331202	0.35	FAM129B	family with sequence similarity 129, member B	703	0.67
chr17_19045376_19045568	0.35	CTC-457L16.2		1530	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP4_MSC

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.2	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.3	1.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.2	0.7	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.2	0.9	GO:0010996	response to auditory stimulus(GO:0010996)
0.1	0.4	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618) regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1	0.8	GO:0016264	gap junction assembly(GO:0016264)
0.1	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.4	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.5	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.1	0.3	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.1	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.1	0.3	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1	0.2	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.1	0.4	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.3	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.3	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1	0.3	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.1	0.3	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.1	0.6	GO:0001553	luteinization(GO:0001553)
0.1	0.2	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.5	GO:0031269	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.1	0.2	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.1	0.3	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.1	0.1	GO:0071288	cellular response to mercury ion(GO:0071288)
0.1	0.2	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.1	0.3	GO:0006533	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.1	0.3	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.2	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.1	0.2	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.1	0.1	GO:0061299	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.3	GO:0006910	phagocytosis, recognition(GO:0006910)
0.1	0.3	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1	0.3	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.1	0.2	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.1	0.2	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1	0.2	GO:0031659	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.1	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.1	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.1	0.3	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.1	0.2	GO:0070327	thyroid hormone transport(GO:0070327)
0.1	0.3	GO:0033630	positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.1	0.4	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.1	0.3	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.4	GO:0071320	cellular response to cAMP(GO:0071320)
0.1	0.1	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.1	0.2	GO:0034063	stress granule assembly(GO:0034063)
0.1	0.3	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1	0.2	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.1	0.2	GO:0007413	axonal fasciculation(GO:0007413)
0.1	0.7	GO:0048844	artery morphogenesis(GO:0048844)
0.1	0.2	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1	0.2	GO:0015801	aromatic amino acid transport(GO:0015801)
0.1	0.2	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.1	0.3	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.4	GO:0046321	positive regulation of fatty acid oxidation(GO:0046321)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.6	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.2	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.3	GO:0015871	choline transport(GO:0015871)
0.0	0.2	GO:0008218	bioluminescence(GO:0008218)
0.0	0.4	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.2	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.3	GO:0048841	regulation of axon extension involved in axon guidance(GO:0048841)
0.0	0.2	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0001743	optic placode formation(GO:0001743)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0060073	micturition(GO:0060073)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0021830	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.2	GO:0060754	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.0	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.2	GO:0042745	circadian sleep/wake cycle(GO:0042745)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.6	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0060068	vagina development(GO:0060068)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.2	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.1	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.0	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.2	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.3	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.1	GO:0021891	olfactory bulb interneuron development(GO:0021891)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.2	GO:0016246	RNA interference(GO:0016246)
0.0	0.0	GO:0090218	positive regulation of lipid kinase activity(GO:0090218)
0.0	0.2	GO:1903393	positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.1	GO:0010544	negative regulation of platelet activation(GO:0010544)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.0	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0055091	phospholipid homeostasis(GO:0055091)
0.0	0.1	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.6	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.3	GO:0030325	adrenal gland development(GO:0030325)
0.0	0.4	GO:0002675	positive regulation of acute inflammatory response(GO:0002675)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0032347	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.2	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.1	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0061047	foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.2	GO:0043537	negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.0	0.2	GO:0031000	response to caffeine(GO:0031000)
0.0	0.1	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.6	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0	0.1	GO:0048520	positive regulation of behavior(GO:0048520)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0051594	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.0	GO:0042663	endodermal cell fate commitment(GO:0001711) endodermal cell fate specification(GO:0001714) regulation of gastrulation(GO:0010470) endodermal cell differentiation(GO:0035987) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:1903519	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0060029	convergent extension involved in organogenesis(GO:0060029)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.2	GO:0001893	maternal placenta development(GO:0001893)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.4	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:1901881	positive regulation of protein depolymerization(GO:1901881)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	2.7	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	0.9	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
0.0	0.0	GO:0021984	adenohypophysis development(GO:0021984)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.0	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0042693	muscle cell fate commitment(GO:0042693)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0021895	cerebral cortex neuron differentiation(GO:0021895)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.0	GO:0001660	fever generation(GO:0001660)
0.0	0.2	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144)
0.0	0.1	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0036473	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.0	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0042090	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.1	GO:0021754	facial nucleus development(GO:0021754)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0006577	amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.0	GO:0071470	cellular response to osmotic stress(GO:0071470)
0.0	0.0	GO:0044321	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0031998	regulation of fatty acid beta-oxidation(GO:0031998)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.0	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0051966	regulation of synaptic transmission, glutamatergic(GO:0051966)
0.0	0.1	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.0	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.1	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.0	0.1	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.0	GO:0061140	lung secretory cell differentiation(GO:0061140)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.2	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.0	0.0	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0	0.2	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0055093	response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0	0.0	GO:0017000	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0008614	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.0	GO:0045988	negative regulation of striated muscle contraction(GO:0045988)
0.0	0.0	GO:0060027	convergent extension involved in gastrulation(GO:0060027)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.4	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.0	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0007635	chemosensory behavior(GO:0007635)
0.0	0.1	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.0	GO:0060412	ventricular septum morphogenesis(GO:0060412)
0.0	0.0	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.1	GO:0008038	neuron recognition(GO:0008038)
0.0	0.1	GO:0051788	response to misfolded protein(GO:0051788)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.0	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0071295	cellular response to vitamin(GO:0071295)
0.0	0.0	GO:0070527	platelet aggregation(GO:0070527)
0.0	0.2	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0042354	fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0	0.0	GO:0044319	wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505)
0.0	0.0	GO:0019731	antibacterial humoral response(GO:0019731)
0.0	0.2	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.0	0.0	GO:0045920	negative regulation of exocytosis(GO:0045920)
0.0	0.0	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0003407	neural retina development(GO:0003407)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.0	GO:0044557	relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0	0.1	GO:0048821	erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0	0.2	GO:0050432	catecholamine secretion(GO:0050432)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.2	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.1	GO:0006863	purine nucleobase transport(GO:0006863)
0.0	0.1	GO:0007263	nitric oxide mediated signal transduction(GO:0007263)
0.0	0.2	GO:0046329	negative regulation of JNK cascade(GO:0046329)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.1	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0043407	negative regulation of MAP kinase activity(GO:0043407)
0.0	0.0	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0043113	receptor clustering(GO:0043113)
0.0	0.0	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0090049	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) regulation of sprouting angiogenesis(GO:1903670) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0010155	regulation of proton transport(GO:0010155)
0.0	0.0	GO:0046337	phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.0	GO:0032823	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.0	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0097094	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.0	GO:0051280	negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion import(GO:0090281) negative regulation of calcium ion transmembrane transport(GO:1903170) negative regulation of cation transmembrane transport(GO:1904063)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0043551	regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0	0.0	GO:0045117	azole transport(GO:0045117)
0.0	0.1	GO:0034394	protein localization to cell surface(GO:0034394)
0.0	0.0	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.0	0.0	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.1	GO:0001974	blood vessel remodeling(GO:0001974)
0.0	0.0	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.0	GO:0007042	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.2	GO:0070374	positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.0	0.1	GO:0060438	trachea development(GO:0060438)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0048875	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:0008595	tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0	0.1	GO:0016075	rRNA catabolic process(GO:0016075)
0.0	0.0	GO:0046599	regulation of centriole replication(GO:0046599)
0.0	0.1	GO:0071624	positive regulation of granulocyte chemotaxis(GO:0071624)
0.0	0.1	GO:0048265	response to pain(GO:0048265)
0.0	0.0	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.0	GO:0051590	positive regulation of neurotransmitter transport(GO:0051590)
0.0	0.0	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.0	GO:0052305	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.3	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	0.4	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	0.6	GO:0071437	invadopodium(GO:0071437)
0.1	0.4	GO:0043259	laminin-10 complex(GO:0043259)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.8	GO:0005614	interstitial matrix(GO:0005614)
0.1	0.3	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	0.5	GO:0005915	zonula adherens(GO:0005915)
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.6	GO:0043205	fibril(GO:0043205)
0.1	0.4	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	0.2	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1	0.2	GO:0070852	cell body fiber(GO:0070852)
0.1	0.2	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.3	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.1	GO:0002139	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.2	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.3	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.2	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.9	GO:0098636	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0008091	spectrin(GO:0008091)
0.0	0.4	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.5	GO:0005922	connexon complex(GO:0005922)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.7	GO:0034704	calcium channel complex(GO:0034704)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.2	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.2	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.3	GO:0044447	axoneme part(GO:0044447)
0.0	0.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.2	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.1	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.7	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	0.2	GO:0005581	collagen trimer(GO:0005581)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0042581	specific granule(GO:0042581)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.1	GO:0031082	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.3	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.1	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.8	GO:0034707	chloride channel complex(GO:0034707)
0.0	0.1	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	1.3	GO:0005912	adherens junction(GO:0005912)
0.0	0.1	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	2.9	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	0.0	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.0	GO:0001940	male pronucleus(GO:0001940)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.1	GO:0030286	dynein complex(GO:0030286)
0.0	0.6	GO:0030426	growth cone(GO:0030426)
0.0	0.1	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.1	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.0	GO:0030427	site of polarized growth(GO:0030427)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.1	GO:0050815	phosphoserine binding(GO:0050815)
0.3	0.8	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.2	0.5	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.4	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.4	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.4	GO:0004995	tachykinin receptor activity(GO:0004995)
0.1	0.4	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.3	GO:0016151	nickel cation binding(GO:0016151)
0.1	0.3	GO:1901474	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.1	0.3	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1	0.5	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1	0.5	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.3	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.1	0.2	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	0.2	GO:0016362	activin receptor activity, type II(GO:0016362)
0.1	0.2	GO:0050897	cobalt ion binding(GO:0050897)
0.1	0.2	GO:0030343	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1	0.2	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.1	0.2	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.3	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.1	0.6	GO:0017166	vinculin binding(GO:0017166)
0.1	0.2	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.3	GO:0001515	opioid peptide activity(GO:0001515)
0.1	0.2	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.1	0.2	GO:0005534	galactose binding(GO:0005534)
0.1	0.2	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.1	0.2	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1	0.4	GO:0004630	phospholipase D activity(GO:0004630)
0.1	0.2	GO:0042805	actinin binding(GO:0042805)
0.1	0.3	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.1	0.2	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.3	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1	0.3	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.1	0.6	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.1	0.5	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1	0.6	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.3	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.3	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.2	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.5	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.3	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	1.5	GO:0005518	collagen binding(GO:0005518)
0.0	0.5	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.3	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.3	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.3	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.4	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.2	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.2	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
0.0	0.3	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.2	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.2	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0034595	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.3	GO:0030971	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.2	GO:0005112	Notch binding(GO:0005112)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.3	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.0	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.1	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.1	GO:0051378	serotonin binding(GO:0051378)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.2	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.0	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.0	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.0	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.0	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	1.2	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0016595	glutamate binding(GO:0016595)
0.0	0.0	GO:0099589	G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0	0.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.0	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.0	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.0	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.7	GO:0005254	chloride channel activity(GO:0005254)
0.0	0.1	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.0	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.1	GO:0000976	transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0	0.0	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.6	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.7	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.4	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.4	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.3	NABA COLLAGENS	Genes encoding collagen proteins
0.9	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.8	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.3	PID S1P S1P2 PATHWAY	S1P2 pathway
0.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.6	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.4	PID NECTIN PATHWAY	Nectin adhesion pathway
0.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	PID IL3 PATHWAY	IL3-mediated signaling events
0.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
2.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.2	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.1	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.1	0.5	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.6	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	1.1	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.5	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.2	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.4	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.3	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.5	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.2	REACTOME GAP JUNCTION TRAFFICKING	Genes involved in Gap junction trafficking
0.0	0.2	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.3	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.2	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.0	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.0	1.1	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.0	0.4	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.3	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.4	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.3	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.0	0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.2	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.0	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0	0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.1	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.1	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	0.0	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.1	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.0	0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.2	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.1	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.0	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.0	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.2	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1

Results for TFAP4_MSC

Z-value: 1.43

Motif logo

Transcription factors associated with TFAP4_MSC

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the TFAP4_MSC motif across conditions

Conditions sorted by the z-value of the TFAP4_MSC motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP4_MSC

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: