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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TFCP2

Z-value: 1.30

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Transcription factors associated with TFCP2

Gene Symbol	Gene ID	Gene Info
TFCP2 Ensembl NCBI GeneCards UniProt	ENSG00000135457.5	TFCP2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
TFCP2	chr12_51565743_51565945	732	0.557665	0.77	1.6e-02	Click!
TFCP2	chr12_51567069_51567255	236	0.890721	-0.32	4.0e-01	Click!
TFCP2	chr12_51566615_51566911	68	0.958729	-0.27	4.8e-01	Click!
TFCP2	chr12_51563573_51563724	2928	0.174409	-0.22	5.7e-01	Click!
TFCP2	chr12_51566002_51566548	301	0.850201	0.21	5.8e-01	Click!

Activity of the TFCP2 motif across conditions

Conditions sorted by the z-value of the TFCP2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_217929529_217929680	0.52	ENSG00000251849	.	111617	0.06
chr15_48936207_48936433	0.48	FBN1	fibrillin 1	1598	0.51
chr3_106954545_106954751	0.43	ENSG00000220989	.	129381	0.06
chr4_16899159_16899373	0.43	LDB2	LIM domain binding 2	919	0.75
chr22_40672488_40672756	0.42	TNRC6B	trinucleotide repeat containing 6B	11615	0.23
chr18_56245541_56245920	0.39	RP11-126O1.2		21428	0.14
chrX_34673275_34673426	0.36	TMEM47	transmembrane protein 47	2055	0.5
chr4_55096991_55097208	0.36	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	610	0.82
chr15_96870719_96871095	0.34	NR2F2-AS1	NR2F2 antisense RNA 1	317	0.84
chr7_15725092_15725754	0.33	MEOX2	mesenchyme homeobox 2	1014	0.63
chr17_67137803_67138011	0.33	ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6	108	0.97
chr7_19152487_19152712	0.33	AC003986.6		502	0.75
chr9_18297085_18297314	0.32	ADAMTSL1	ADAMTS-like 1	176693	0.03
chr1_26348142_26348482	0.32	EXTL1	exostosin-like glycosyltransferase 1	41	0.95
chr15_70994869_70995020	0.31	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	297	0.94
chr3_52737763_52738047	0.30	GLT8D1	glycosyltransferase 8 domain containing 1	270	0.75
chr11_119211431_119211655	0.30	C1QTNF5	C1q and tumor necrosis factor related protein 5	50	0.94
chr14_55707492_55707643	0.30	FBXO34	F-box protein 34	30454	0.18
chr5_158488269_158488591	0.30	EBF1	early B-cell factor 1	38271	0.17
chr6_3389887_3390179	0.29	SLC22A23	solute carrier family 22, member 23	49619	0.15
chr10_101767094_101767245	0.29	DNMBP	dynamin binding protein	2507	0.28
chr1_114522141_114522332	0.29	OLFML3	olfactomedin-like 3	171	0.95
chr5_129241672_129241829	0.28	CTC-575N7.1		140	0.95
chr15_48936731_48936882	0.28	FBN1	fibrillin 1	1112	0.63
chrX_34671991_34672311	0.28	TMEM47	transmembrane protein 47	3254	0.41
chr8_13355358_13355509	0.28	DLC1	deleted in liver cancer 1	1317	0.52
chr3_29321285_29321499	0.27	RBMS3	RNA binding motif, single stranded interacting protein 3	1081	0.59
chr12_76422291_76422442	0.27	RP11-290L1.3		1908	0.31
chr13_37492943_37493377	0.27	SMAD9	SMAD family member 9	1215	0.52
chr19_55972195_55972559	0.27	ISOC2	isochorismatase domain containing 2	559	0.55
chr17_15522812_15523031	0.27	CDRT1	CMT1A duplicated region transcript 1	95	0.95
chr12_48395504_48395664	0.26	COL2A1	collagen, type II, alpha 1	2520	0.21
chr2_102089965_102090218	0.26	RFX8	RFX family member 8, lacking RFX DNA binding domain	646	0.8
chr11_131780761_131781452	0.26	NTM	neurotrimin	209	0.95
chr13_76054815_76055003	0.26	TBC1D4	TBC1 domain family, member 4	1341	0.51
chr10_3666636_3666787	0.26	RP11-184A2.3		126548	0.06
chr2_66667990_66668184	0.26	MEIS1	Meis homeobox 1	277	0.68
chr16_11445129_11445310	0.26	RP11-485G7.6		2041	0.16
chr2_216297601_216297993	0.26	FN1	fibronectin 1	2993	0.27
chr11_118435857_118436109	0.25	IFT46	intraflagellar transport 46 homolog (Chlamydomonas)	378	0.76
chr3_119180886_119181037	0.25	TMEM39A	transmembrane protein 39A	1502	0.36
chr5_78760442_78760593	0.25	HOMER1	homer homolog 1 (Drosophila)	48100	0.16
chr7_46895478_46895629	0.25	AC011294.3	Uncharacterized protein	158833	0.04
chr14_61492437_61492630	0.25	SLC38A6	solute carrier family 38, member 6	17335	0.21
chr12_119617823_119618008	0.25	HSPB8	heat shock 22kDa protein 8	520	0.73
chr1_212734986_212735137	0.25	ATF3	activating transcription factor 3	3615	0.24
chr12_50614114_50614771	0.25	RP3-405J10.4		1055	0.35
chr15_60684258_60684446	0.25	ANXA2	annexin A2	856	0.71
chr16_11085461_11085694	0.25	CLEC16A	C-type lectin domain family 16, member A	47139	0.1
chr1_190447721_190448034	0.24	BRINP3	bone morphogenetic protein/retinoic acid inducible neural-specific 3	1118	0.69
chr5_137390877_137391028	0.24	FAM13B	family with sequence similarity 13, member B	3302	0.16
chr7_116035241_116035541	0.24	ENSG00000252672	.	37877	0.14
chr15_96883311_96883827	0.24	ENSG00000222651	.	7079	0.16
chr21_46629242_46629401	0.24	ADARB1	adenosine deaminase, RNA-specific, B1	37764	0.14
chr8_72460104_72460292	0.24	RP11-1102P16.1	Uncharacterized protein	306	0.94
chr5_14448576_14448727	0.24	TRIO	trio Rho guanine nucleotide exchange factor	39906	0.21
chr13_36049575_36050388	0.24	MAB21L1	mab-21-like 1 (C. elegans)	851	0.43
chr1_196622943_196623164	0.24	CFH	complement factor H	1867	0.41
chr15_34786644_34787173	0.24	ENSG00000221065	.	33664	0.14
chr20_53092813_53093232	0.24	DOK5	docking protein 5	765	0.8
chr6_85896028_85896266	0.24	NT5E	5'-nucleotidase, ecto (CD73)	263662	0.02
chr19_11563038_11563189	0.24	ENSG00000238349	.	13116	0.08
chr14_55117285_55117487	0.24	SAMD4A	sterile alpha motif domain containing 4A	82749	0.09
chr6_27516181_27516437	0.24	ENSG00000206671	.	47882	0.13
chr11_125929704_125929855	0.23	CDON	cell adhesion associated, oncogene regulated	2927	0.28
chr5_79421582_79421788	0.23	CTC-458I2.2		2499	0.32
chr1_164534283_164534434	0.23	PBX1	pre-B-cell leukemia homeobox 1	2316	0.4
chr17_32583150_32583439	0.23	AC005549.3	Uncharacterized protein	988	0.32
chr22_45898941_45899504	0.23	FBLN1	fibulin 1	296	0.92
chr5_82770538_82771175	0.23	VCAN	versican	3112	0.37
chr1_39733773_39734441	0.23	MACF1	microtubule-actin crosslinking factor 1	92	0.97
chr12_72665965_72666270	0.23	ENSG00000236333	.	189	0.69
chr10_128994049_128994367	0.23	FAM196A	family with sequence similarity 196, member A	214	0.97
chr18_56244732_56244930	0.23	RP11-126O1.2		20529	0.14
chr12_105727681_105727958	0.23	C12orf75	chromosome 12 open reading frame 75	3173	0.24
chr5_35129380_35129531	0.23	PRLR	prolactin receptor	991	0.64
chr4_67431234_67431385	0.23	ENSG00000221563	.	288767	0.01
chr14_50089328_50089479	0.23	RP11-649E7.5		795	0.35
chr18_55470424_55470575	0.23	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	172	0.96
chr1_23066485_23066803	0.23	ENSG00000216157	.	8760	0.17
chr2_119532290_119532494	0.22	EN1	engrailed homeobox 1	72862	0.12
chr4_26023554_26023967	0.22	SMIM20	small integral membrane protein 20	107829	0.07
chr1_98510769_98511355	0.22	ENSG00000225206	.	155	0.98
chr7_128471351_128471889	0.22	FLNC	filamin C, gamma	1140	0.39
chr1_240501387_240501653	0.22	ENSG00000252317	.	3165	0.32
chr4_19691164_19691362	0.22	ENSG00000251816	.	507784	0.0
chr12_110705323_110705474	0.22	ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	13163	0.23
chr11_133903795_133903999	0.22	JAM3	junctional adhesion molecule 3	34923	0.17
chr10_95518290_95518441	0.22	LGI1	leucine-rich, glioma inactivated 1	687	0.76
chr9_110811607_110811808	0.22	ENSG00000222459	.	130448	0.05
chr17_47210248_47210565	0.22	B4GALNT2	beta-1,4-N-acetyl-galactosaminyl transferase 2	77	0.97
chr12_40013401_40013886	0.22	ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	90	0.98
chr18_7460861_7461013	0.22	PTPRM	protein tyrosine phosphatase, receptor type, M	105843	0.07
chr1_86045223_86045434	0.22	CYR61	cysteine-rich, angiogenic inducer, 61	1116	0.4
chr15_102156310_102156522	0.22	ENSG00000252614	.	32099	0.15
chrX_45626308_45626459	0.21	ENSG00000207725	.	19853	0.22
chr6_37663843_37664045	0.21	MDGA1	MAM domain containing glycosylphosphatidylinositol anchor 1	643	0.8
chr12_125395024_125395175	0.21	UBC	ubiquitin C	3521	0.19
chr1_87670295_87670446	0.21	ENSG00000221222	.	53389	0.16
chrX_64255707_64255858	0.21	ZC4H2	zinc finger, C4H2 domain containing	1189	0.66
chr10_62174775_62175056	0.21	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	25427	0.28
chr1_215130950_215131319	0.21	KCNK2	potassium channel, subfamily K, member 2	48064	0.2
chr3_105555914_105556177	0.21	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	31842	0.26
chr10_92680601_92680752	0.21	ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	357	0.84
chr1_78474827_78475270	0.21	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	4510	0.17
chr3_187870695_187870846	0.21	LPP	LIM domain containing preferred translocation partner in lipoma	302	0.84
chr2_75792595_75792746	0.21	EVA1A	eva-1 homolog A (C. elegans)	4178	0.2
chr17_772969_773237	0.21	NXN	nucleoredoxin	5752	0.17
chr1_117028958_117029109	0.21	ENSG00000200547	.	33875	0.13
chr16_86549558_86549709	0.21	FOXF1	forkhead box F1	5500	0.21
chr14_77294740_77294891	0.21	C14orf166B	chromosome 14 open reading frame 166B	140	0.96
chr12_78684646_78684797	0.21	NAV3	neuron navigator 3	91865	0.1
chr10_31410381_31410532	0.21	ENSG00000263578	.	55480	0.15
chr14_42077252_42077403	0.21	LRFN5	leucine rich repeat and fibronectin type III domain containing 5	291	0.93
chr6_11230027_11230357	0.21	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	2699	0.33
chr3_114378409_114378560	0.21	ZBTB20	zinc finger and BTB domain containing 20	34692	0.22
chr19_16493261_16493427	0.20	ENSG00000243745	.	16426	0.13
chr20_53239107_53239289	0.20	DOK5	docking protein 5	146941	0.05
chr18_65662332_65662579	0.20	DSEL	dermatan sulfate epimerase-like	478238	0.01
chr15_56206090_56206310	0.20	NEDD4	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	1652	0.45
chr4_146052413_146052564	0.20	ENSG00000238713	.	18313	0.17
chrX_34673509_34673660	0.20	TMEM47	transmembrane protein 47	1821	0.53
chr11_27603199_27603543	0.20	BDNF-AS	BDNF antisense RNA	58065	0.11
chr6_151392043_151392194	0.20	RP1-292B18.3		14925	0.18
chr19_30941733_30942003	0.20	ZNF536	zinc finger protein 536	78549	0.12
chr4_177712658_177713139	0.20	VEGFC	vascular endothelial growth factor C	983	0.71
chr6_35286420_35286751	0.20	DEF6	differentially expressed in FDCP 6 homolog (mouse)	9070	0.18
chrX_51636554_51637686	0.20	MAGED1	melanoma antigen family D, 1	385	0.89
chr4_41615256_41615763	0.20	LIMCH1	LIM and calponin homology domains 1	16	0.99
chr5_92937754_92938000	0.20	ENSG00000237187	.	16523	0.18
chr4_39527980_39528193	0.20	UGDH	UDP-glucose 6-dehydrogenase	91	0.95
chr11_76380846_76381073	0.20	LRRC32	leucine rich repeat containing 32	85	0.97
chr1_60204181_60204332	0.20	ENSG00000266150	.	5288	0.28
chr19_36736141_36736420	0.20	ZNF565	zinc finger protein 565	879	0.5
chr6_169652381_169652976	0.20	THBS2	thrombospondin 2	432	0.89
chr15_37179413_37179956	0.20	ENSG00000212511	.	34843	0.22
chr9_102130860_102131451	0.20	ENSG00000222337	.	84851	0.09
chr8_129852489_129852640	0.20	ENSG00000221351	.	20524	0.29
chr9_119449393_119449768	0.20	TRIM32	tripartite motif containing 32	1	0.54
chr8_96734481_96734632	0.20	ENSG00000223297	.	43413	0.2
chr17_57449049_57449286	0.19	ENSG00000263857	.	5723	0.19
chrX_135771582_135771733	0.19	CD40LG	CD40 ligand	41271	0.12
chr9_1917275_1917426	0.19	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	97992	0.08
chr9_82301184_82301335	0.19	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	18439	0.31
chr5_33442964_33443296	0.19	TARS	threonyl-tRNA synthetase	1643	0.41
chr22_31092194_31092345	0.19	OSBP2	oxysterol binding protein 2	1393	0.36
chr10_63422698_63423173	0.19	C10orf107	chromosome 10 open reading frame 107	180	0.96
chr7_107886376_107886580	0.19	NRCAM	neuronal cell adhesion molecule	2794	0.37
chr7_18127374_18127525	0.19	HDAC9	histone deacetylase 9	877	0.66
chr13_53173841_53174134	0.19	HNRNPA1L2	heterogeneous nuclear ribonucleoprotein A1-like 2	17618	0.22
chr10_118547842_118547993	0.19	HSPA12A	heat shock 70kDa protein 12A	45832	0.13
chr15_59622460_59622641	0.19	ENSG00000199512	.	11066	0.14
chr4_15471787_15471987	0.19	CC2D2A	coiled-coil and C2 domain containing 2A	250	0.93
chr10_375832_375983	0.19	DIP2C	DIP2 disco-interacting protein 2 homolog C (Drosophila)	441	0.85
chr10_32153572_32153723	0.19	ARHGAP12	Rho GTPase activating protein 12	10539	0.28
chr6_113994297_113994452	0.19	ENSG00000221559	.	31661	0.2
chr11_71750979_71751491	0.19	NUMA1	nuclear mitotic apparatus protein 1	364	0.76
chr13_36491458_36491923	0.19	DCLK1	doublecortin-like kinase 1	61911	0.15
chr11_19092979_19093139	0.19	MRGPRX2	MAS-related GPR, member X2	10831	0.22
chr17_48797815_48798020	0.19	LUC7L3	LUC7-like 3 (S. cerevisiae)	909	0.47
chr16_79605167_79605329	0.19	MAF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog	28551	0.25
chr6_86159077_86159694	0.19	NT5E	5'-nucleotidase, ecto (CD73)	424	0.9
chr9_179160_179373	0.19	CBWD1	COBW domain containing 1	194	0.94
chrX_54947220_54948504	0.19	TRO	trophinin	41	0.97
chr20_42087598_42088018	0.19	SRSF6	serine/arginine-rich splicing factor 6	1240	0.39
chr11_79148234_79148400	0.19	TENM4	teneurin transmembrane protein 4	3378	0.27
chr10_4223311_4223462	0.19	ENSG00000207124	.	333758	0.01
chr1_117912075_117912374	0.18	MAN1A2	mannosidase, alpha, class 1A, member 2	2153	0.44
chr4_108539974_108540125	0.18	PAPSS1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	101559	0.08
chr19_14444112_14444508	0.18	CD97	CD97 molecule	47658	0.1
chr12_107352268_107352490	0.18	C12orf23	chromosome 12 open reading frame 23	1816	0.3
chr2_44404368_44404519	0.18	PPM1B	protein phosphatase, Mg2+/Mn2+ dependent, 1B	8394	0.18
chr15_49063488_49063639	0.18	RP11-485O10.2		11824	0.19
chr2_150505079_150505230	0.18	ENSG00000207270	.	37866	0.18
chr8_54797720_54797871	0.18	RGS20	regulator of G-protein signaling 20	4341	0.21
chr19_14605870_14606060	0.18	GIPC1	GIPC PDZ domain containing family, member 1	979	0.38
chr6_22881696_22881893	0.18	ENSG00000207394	.	243521	0.02
chr2_42159815_42159972	0.18	C2orf91	chromosome 2 open reading frame 91	21050	0.21
chr13_80707220_80707565	0.18	SPRY2	sprouty homolog 2 (Drosophila)	206402	0.03
chr9_91093036_91093232	0.18	NXNL2	nucleoredoxin-like 2	56882	0.14
chr20_3778661_3778819	0.18	CDC25B	cell division cycle 25B	1662	0.25
chr10_33410829_33411028	0.18	ENSG00000263576	.	23364	0.21
chr7_43605854_43606005	0.18	ENSG00000252308	.	12558	0.18
chr3_161633215_161633436	0.18	OTOL1	otolin 1	418729	0.01
chr3_139000860_139001011	0.18	MRPS22	mitochondrial ribosomal protein S22	61926	0.1
chr6_90695271_90695484	0.18	ENSG00000222078	.	15848	0.19
chr6_85836289_85836440	0.18	NT5E	5'-nucleotidase, ecto (CD73)	323445	0.01
chr6_99284839_99284990	0.18	POU3F2	POU class 3 homeobox 2	2334	0.45
chr8_80525611_80525912	0.18	STMN2	stathmin-like 2	1791	0.51
chr13_111862424_111862612	0.18	ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	4882	0.27
chr7_707964_708478	0.18	PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta	23210	0.18
chr7_94030181_94030408	0.18	COL1A2	collagen, type I, alpha 2	6421	0.29
chr22_40706773_40706982	0.18	ADSL	adenylosuccinate lyase	35630	0.14
chr1_214620651_214620839	0.18	PTPN14	protein tyrosine phosphatase, non-receptor type 14	17401	0.26
chr1_156677371_156677522	0.18	CRABP2	cellular retinoic acid binding protein 2	1838	0.18
chr3_183966275_183966684	0.18	ALG3	ALG3, alpha-1,3- mannosyltransferase	244	0.79
chr2_192110869_192111020	0.18	MYO1B	myosin IB	65	0.98
chr4_186064841_186065084	0.18	SLC25A4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	567	0.76
chr7_93925404_93925563	0.18	COL1A2	collagen, type I, alpha 2	98390	0.08
chr1_33645945_33646389	0.18	TRIM62	tripartite motif containing 62	1100	0.55

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFCP2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.6	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.4	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.3	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.2	GO:0048368	lateral mesoderm development(GO:0048368)
0.1	0.2	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.1	0.2	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.2	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.1	0.2	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.1	0.1	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.1	0.2	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.1	0.2	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.2	GO:0060242	contact inhibition(GO:0060242)
0.1	0.2	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.1	0.1	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1	0.2	GO:0001757	somite specification(GO:0001757)
0.1	0.2	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.1	0.2	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.2	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.2	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.1	0.2	GO:0051451	myoblast migration(GO:0051451)
0.1	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.2	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.1	0.4	GO:0001553	luteinization(GO:0001553)
0.1	0.2	GO:0060753	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.4	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.2	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0072070	loop of Henle development(GO:0072070)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.2	GO:0015853	adenine transport(GO:0015853)
0.0	0.1	GO:0060592	mammary gland formation(GO:0060592) mammary placode formation(GO:0060596)
0.0	0.2	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.1	GO:0060453	regulation of gastric acid secretion(GO:0060453)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.1	GO:2000053	Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.1	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:2000050	regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0006188	IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0	0.6	GO:0035136	forelimb morphogenesis(GO:0035136)
0.0	0.3	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.2	GO:0008347	glial cell migration(GO:0008347)
0.0	0.1	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.1	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.3	GO:0032400	melanosome localization(GO:0032400)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.0	GO:0061687	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.2	GO:0043949	regulation of cAMP-mediated signaling(GO:0043949)
0.0	0.0	GO:0021799	cerebral cortex radially oriented cell migration(GO:0021799)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.0	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:1901798	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0001779	natural killer cell differentiation(GO:0001779) regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.0	GO:0031223	auditory behavior(GO:0031223)
0.0	0.0	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.0	0.2	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.0	0.2	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.2	GO:0031290	retinal ganglion cell axon guidance(GO:0031290)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.2	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:1901890	positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.0	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.2	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.0	GO:0007619	courtship behavior(GO:0007619)
0.0	0.0	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.0	0.1	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0048520	positive regulation of behavior(GO:0048520)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.3	GO:0031111	negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0	0.1	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.1	GO:0014034	neural crest formation(GO:0014029) neural crest cell fate commitment(GO:0014034)
0.0	0.2	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0	0.1	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0021904	dorsal/ventral neural tube patterning(GO:0021904)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.0	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.0	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0046606	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.3	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.1	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0002887	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:0019348	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.0	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.0	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.0	GO:0021794	thalamus development(GO:0021794)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.1	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.2	GO:0002027	regulation of heart rate(GO:0002027)
0.0	0.0	GO:0032730	regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.1	GO:0042474	middle ear morphogenesis(GO:0042474)
0.0	0.0	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0	0.0	GO:0060297	regulation of sarcomere organization(GO:0060297)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.0	GO:0040023	establishment of nucleus localization(GO:0040023)
0.0	0.1	GO:0051963	regulation of synapse assembly(GO:0051963)
0.0	0.0	GO:0034244	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.0	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.0	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0000090	mitotic anaphase(GO:0000090)
0.0	0.1	GO:0010171	body morphogenesis(GO:0010171)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.0	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.0	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.0	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.0	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.0	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.2	GO:0008038	neuron recognition(GO:0008038)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0042745	circadian sleep/wake cycle(GO:0042745)
0.0	0.1	GO:0006777	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.0	GO:0002248	wound healing involved in inflammatory response(GO:0002246) connective tissue replacement involved in inflammatory response wound healing(GO:0002248) inflammatory response to wounding(GO:0090594) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0045773	positive regulation of axon extension(GO:0045773)
0.0	0.1	GO:0030325	adrenal gland development(GO:0030325)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.0	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.1	GO:0009437	amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.0	0.2	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.0	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0	0.1	GO:0032651	regulation of interleukin-1 beta production(GO:0032651)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0001527	microfibril(GO:0001527)
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.5	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.2	GO:0031430	M band(GO:0031430)
0.0	0.2	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.1	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.2	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0001741	XY body(GO:0001741)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0005655	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.7	GO:0044853	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0	0.0	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	0.0	GO:0031501	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.0	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0031941	filamentous actin(GO:0031941)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.0	GO:0032059	bleb(GO:0032059)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.3	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1	0.2	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.1	0.2	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.1	0.2	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.3	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.2	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.2	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.2	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.2	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.3	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.3	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.3	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.3	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.4	GO:0017022	myosin binding(GO:0017022)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.2	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	1.4	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0005237	inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.3	GO:0045296	cadherin binding(GO:0045296)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.1	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.4	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.0	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.1	GO:0016530	metallochaperone activity(GO:0016530)
0.0	0.0	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0019841	retinol binding(GO:0019841)
0.0	0.0	GO:0048156	tau protein binding(GO:0048156)
0.0	0.0	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.0	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.0	GO:0043176	amine binding(GO:0043176)
0.0	0.1	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.0	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.0	GO:0034711	inhibin binding(GO:0034711)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.0	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.0	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0016783	sulfurtransferase activity(GO:0016783)
0.0	0.1	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.7	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
1.0	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.5	PID ERBB4 PATHWAY	ErbB4 signaling events
0.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.3	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.3	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.2	PID ALK1 PATHWAY	ALK1 signaling events
0.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.4	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.5	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.3	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.6	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.1	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.3	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.1	REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	Genes involved in Activation of Chaperones by ATF6-alpha
0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.2	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.4	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4