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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TFCP2L1

Z-value: 0.61

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Transcription factors associated with TFCP2L1

Gene Symbol	Gene ID	Gene Info
TFCP2L1 Ensembl NCBI GeneCards UniProt	ENSG00000115112.7	TFCP2L1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
TFCP2L1	chr2_122030038_122030189	12670	0.291267	0.80	9.3e-03	Click!
TFCP2L1	chr2_121969092_121969243	73616	0.118802	0.78	1.3e-02	Click!
TFCP2L1	chr2_121943565_121943716	99143	0.078577	0.74	2.3e-02	Click!
TFCP2L1	chr2_122040725_122040876	1983	0.473434	0.68	4.3e-02	Click!
TFCP2L1	chr2_122030438_122030589	12270	0.292370	0.66	5.3e-02	Click!

Activity of the TFCP2L1 motif across conditions

Conditions sorted by the z-value of the TFCP2L1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_2143838_2144077	0.40	ENSG00000207805	.	11482	0.11
chr17_73718374_73718525	0.33	ITGB4	integrin, beta 4	872	0.43
chr1_172360185_172360576	0.32	DNM3	dynamin 3	12222	0.16
chr20_55204347_55205219	0.32	TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	425	0.81
chr21_44753087_44753381	0.31	SIK1	salt-inducible kinase 1	93774	0.08
chr2_227660537_227660688	0.29	IRS1	insulin receptor substrate 1	3863	0.25
chr14_105332811_105333071	0.28	CEP170B	centrosomal protein 170B	1287	0.43
chr11_131780111_131780399	0.27	NTM	neurotrimin	642	0.77
chr12_54391177_54391923	0.26	HOXC-AS2	HOXC cluster antisense RNA 2	981	0.22
chr5_2752991_2753357	0.26	C5orf38	chromosome 5 open reading frame 38	795	0.6
chr11_76495400_76495579	0.26	TSKU	tsukushi, small leucine rich proteoglycan	297	0.83
chr16_765872_766413	0.26	METRN	meteorin, glial cell differentiation regulator	432	0.55
chr21_46891372_46891858	0.25	COL18A1	collagen, type XVIII, alpha 1	16191	0.18
chr1_110693132_110693795	0.25	SLC6A17	solute carrier family 6 (neutral amino acid transporter), member 17	355	0.81
chr5_167646669_167646982	0.24	CTB-178M22.2		12537	0.22
chr1_27189686_27189837	0.24	SFN	stratifin	128	0.93
chr20_61467867_61468113	0.23	COL9A3	collagen, type IX, alpha 3	18827	0.11
chr2_227661089_227661317	0.23	IRS1	insulin receptor substrate 1	3272	0.26
chr12_6484544_6484695	0.23	LTBR	lymphotoxin beta receptor (TNFR superfamily, member 3)	24	0.57
chr11_1896066_1896383	0.22	LSP1	lymphocyte-specific protein 1	1483	0.24
chrX_48916544_48916695	0.22	CCDC120	coiled-coil domain containing 120	73	0.94
chr8_42356526_42357223	0.21	SLC20A2	solute carrier family 20 (phosphate transporter), member 2	1887	0.34
chr22_36461534_36461685	0.21	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	37136	0.19
chr12_113859774_113860410	0.21	SDSL	serine dehydratase-like	50	0.97
chr12_52540782_52540933	0.21	ENSG00000265804	.	33148	0.09
chr16_89630259_89630469	0.21	RPL13	ribosomal protein L13	1586	0.22
chr17_75282403_75282641	0.21	SEPT9	septin 9	1451	0.48
chr10_73758338_73758489	0.20	CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	34290	0.18
chr1_32045069_32045220	0.20	TINAGL1	tubulointerstitial nephritis antigen-like 1	3005	0.19
chr3_50193036_50193699	0.20	RP11-493K19.3		86	0.87
chr11_1858026_1858177	0.20	SYT8	synaptotagmin VIII	2067	0.16
chr11_122049732_122050124	0.20	ENSG00000207994	.	26912	0.16
chr3_46428014_46428165	0.20	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	13928	0.14
chr5_150968827_150968978	0.20	FAT2	FAT atypical cadherin 2	20397	0.17
chr18_11689181_11689508	0.20	GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	389	0.89
chr9_132429402_132429765	0.19	PRRX2	paired related homeobox 2	1663	0.28
chr5_135527631_135527866	0.19	TRPC7-AS1	TRPC7 antisense RNA 1	21988	0.18
chr5_131593477_131594185	0.19	PDLIM4	PDZ and LIM domain 4	431	0.81
chr20_33759810_33760395	0.19	PROCR	protein C receptor, endothelial	226	0.9
chr6_16056248_16056399	0.19	MYLIP	myosin regulatory light chain interacting protein	73033	0.1
chr18_77938309_77938600	0.19	AC139100.3		3109	0.25
chr8_144896706_144897508	0.19	SCRIB	scribbled planar cell polarity protein	31	0.94
chr17_878729_878960	0.18	NXN	nucleoredoxin	4166	0.16
chr2_219858277_219858732	0.18	CRYBA2	crystallin, beta A2	361	0.74
chr22_46980499_46980650	0.18	GRAMD4	GRAM domain containing 4	7548	0.22
chr2_238804740_238804891	0.18	ENSG00000263723	.	26268	0.17
chr7_150814571_150814722	0.18	AGAP3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	650	0.56
chr13_114524710_114524921	0.18	GAS6-AS1	GAS6 antisense RNA 1	6212	0.22
chr4_187491209_187491867	0.17	MTNR1A	melatonin receptor 1A	14817	0.17
chr16_75299159_75299651	0.17	BCAR1	breast cancer anti-estrogen resistance 1	292	0.87
chr11_34642741_34642892	0.17	EHF	ets homologous factor	134	0.98
chr10_64324269_64324457	0.17	ZNF365	zinc finger protein 365	44156	0.18
chr12_116563914_116564400	0.17	ENSG00000207967	.	22302	0.2
chr14_105436556_105437076	0.16	AHNAK2	AHNAK nucleoprotein 2	7878	0.16
chr2_150186573_150186784	0.16	LYPD6	LY6/PLAUR domain containing 6	179	0.97
chr2_86444196_86444456	0.16	MRPL35	mitochondrial ribosomal protein L35	17740	0.12
chr22_37823258_37823437	0.16	RP1-63G5.5		133	0.53
chr4_190731965_190732231	0.16	ENSG00000266024	.	7725	0.28
chr17_6459033_6459314	0.16	PITPNM3	PITPNM family member 3	607	0.7
chr19_17953136_17953665	0.16	JAK3	Janus kinase 3	1856	0.22
chr4_20256302_20256578	0.16	SLIT2	slit homolog 2 (Drosophila)	103	0.98
chr7_100876080_100876231	0.16	CLDN15	claudin 15	4886	0.11
chrX_11682905_11683408	0.16	ARHGAP6	Rho GTPase activating protein 6	208	0.97
chr15_37402857_37403086	0.16	MEIS2	Meis homeobox 2	9467	0.23
chr5_131561351_131561783	0.16	P4HA2	prolyl 4-hydroxylase, alpha polypeptide II	1368	0.4
chr5_61212914_61213065	0.16	RP11-2O17.2		218730	0.02
chr6_13761461_13761614	0.15	MCUR1	mitochondrial calcium uniporter regulator 1	40040	0.15
chr4_62067754_62067905	0.15	LPHN3	latrophilin 3	31	0.99
chr2_225905702_225906810	0.15	DOCK10	dedicator of cytokinesis 10	903	0.7
chr1_44030641_44030792	0.15	PTPRF	protein tyrosine phosphatase, receptor type, F	19969	0.18
chr1_149908531_149908774	0.15	MTMR11	myotubularin related protein 11	139	0.92
chr10_61469364_61469637	0.15	SLC16A9	solute carrier family 16, member 9	337	0.94
chr14_55151103_55151261	0.15	SAMD4A	sterile alpha motif domain containing 4A	70369	0.12
chr4_152462150_152462592	0.15	FAM160A1	family with sequence similarity 160, member A1	8207	0.21
chr1_206685419_206685570	0.15	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	4615	0.16
chr6_75911985_75912746	0.15	COL12A1	collagen, type XII, alpha 1	143	0.97
chr9_116356768_116357019	0.15	RGS3	regulator of G-protein signaling 3	1127	0.54
chr17_66596391_66596729	0.15	FAM20A	family with sequence similarity 20, member A	970	0.63
chr2_69238294_69238445	0.15	ANTXR1	anthrax toxin receptor 1	1941	0.36
chr8_145023500_145024036	0.15	PLEC	plectin	1276	0.29
chr1_38100032_38100233	0.15	RSPO1	R-spondin 1	156	0.94
chr1_3382753_3382904	0.15	ARHGEF16	Rho guanine nucleotide exchange factor (GEF) 16	259	0.93
chr1_192776419_192777001	0.15	RGS2	regulator of G-protein signaling 2, 24kDa	1461	0.52
chr4_77561461_77561612	0.15	AC107072.2		2760	0.3
chr11_7273101_7273359	0.14	SYT9	synaptotagmin IX	49	0.98
chr3_9745623_9746706	0.14	CPNE9	copine family member IX	654	0.62
chr5_98113748_98113899	0.14	RGMB	repulsive guidance molecule family member b	4484	0.25
chr4_2066511_2066662	0.14	NAT8L	N-acetyltransferase 8-like (GCN5-related, putative)	5047	0.17
chr1_220906357_220906642	0.14	MARC2	mitochondrial amidoxime reducing component 2	15112	0.19
chr11_66104634_66104935	0.14	RIN1	Ras and Rab interactor 1	473	0.54
chr19_12305803_12306072	0.14	ZNF136	zinc finger protein 136	32006	0.1
chr7_127911991_127912224	0.14	ENSG00000221429	.	17950	0.16
chr3_117715779_117716482	0.14	LSAMP	limbic system-associated membrane protein	35	0.99
chr2_241374262_241374834	0.14	GPC1	glypican 1	540	0.75
chr8_94713195_94713677	0.14	FAM92A1	family with sequence similarity 92, member A1	326	0.7
chr4_10097453_10097846	0.14	ENSG00000264931	.	17333	0.14
chr17_38334308_38334459	0.14	RAPGEFL1	Rap guanine nucleotide exchange factor (GEF)-like 1	118	0.95
chr9_35792725_35792965	0.14	NPR2	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	694	0.46
chr17_74023240_74023391	0.14	EVPL	envoplakin	3	0.96
chrX_118533808_118534027	0.14	SLC25A43	solute carrier family 25, member 43	574	0.64
chr3_184258855_184259006	0.14	EIF2B5-AS1	EIF2B5 antisense RNA 1	15776	0.17
chr17_55950685_55950914	0.14	CUEDC1	CUE domain containing 1	768	0.63
chr3_126725554_126725705	0.14	PLXNA1	plexin A1	18192	0.27
chr8_143869634_143869785	0.14	LY6D	lymphocyte antigen 6 complex, locus D	1701	0.2
chr20_61002159_61002310	0.14	RBBP8NL	RBBP8 N-terminal like	355	0.83
chr5_9544908_9545592	0.14	SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	937	0.56
chr6_3455960_3456202	0.14	SLC22A23	solute carrier family 22, member 23	196	0.97
chr17_15686261_15686502	0.14	ENSG00000251829	.	726	0.64
chr10_127942305_127942518	0.14	ENSG00000222740	.	108260	0.07
chr2_28659437_28659588	0.13	PLB1	phospholipase B1	20500	0.17
chr2_121943565_121943716	0.13	TFCP2L1	transcription factor CP2-like 1	99143	0.08
chr9_85927301_85927452	0.13	FRMD3	FERM domain containing 3	495	0.81
chr1_212415011_212415162	0.13	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	43793	0.13
chr15_91500342_91500803	0.13	RCCD1	RCC1 domain containing 1	1546	0.18
chr9_90812890_90813286	0.13	ENSG00000252299	.	176096	0.03
chr17_48133472_48134260	0.13	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	62	0.96
chr17_5025740_5025978	0.13	ZNF232	zinc finger protein 232	538	0.63
chr14_89506858_89507416	0.13	FOXN3	forkhead box N3	139951	0.05
chr16_87241382_87241645	0.13	RP11-899L11.3		8008	0.23
chr12_59309288_59309823	0.13	LRIG3	leucine-rich repeats and immunoglobulin-like domains 3	1191	0.55
chr20_30557048_30557199	0.13	XKR7	XK, Kell blood group complex subunit-related family, member 7	1318	0.34
chr17_37856067_37857084	0.13	ERBB2	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	242	0.86
chr11_392408_392559	0.13	PKP3	plakophilin 3	131	0.92
chr17_4902045_4902282	0.13	KIF1C	kinesin family member 1C	914	0.26
chr9_98980169_98980538	0.13	ENSG00000265367	.	17851	0.18
chr9_130330127_130331202	0.13	FAM129B	family with sequence similarity 129, member B	703	0.67
chr7_55120970_55121121	0.13	EGFR	epidermal growth factor receptor	34234	0.22
chr2_175206758_175207367	0.13	AC018470.1	Uncharacterized protein FLJ46347	4911	0.18
chr17_11143475_11144119	0.13	SHISA6	shisa family member 6	783	0.71
chr2_239776059_239776362	0.13	TWIST2	twist family bHLH transcription factor 2	19537	0.23
chr2_153399155_153399498	0.13	FMNL2	formin-like 2	76766	0.12
chr11_47561392_47561727	0.13	CELF1	CUGBP, Elav-like family member 1	13110	0.08
chr18_59666418_59666569	0.13	RNF152	ring finger protein 152	105029	0.07
chr2_151342010_151342200	0.12	RND3	Rho family GTPase 3	209	0.97
chr7_101796468_101796619	0.12	ENSG00000252824	.	40901	0.15
chr11_19585849_19586032	0.12	ENSG00000265210	.	10917	0.19
chr2_219081816_219081967	0.12	ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	27	0.96
chr17_72426935_72427098	0.12	GPRC5C	G protein-coupled receptor, family C, group 5, member C	36	0.97
chr21_37850808_37851450	0.12	CLDN14	claudin 14	1259	0.42
chr10_73060971_73061122	0.12	SLC29A3	solute carrier family 29 (equilibrative nucleoside transporter), member 3	17969	0.18
chr8_494094_494251	0.12	TDRP	testis development related protein	665	0.79
chrX_56829451_56830094	0.12	ENSG00000204272	.	74080	0.12
chr6_35360609_35360760	0.12	PPARD	peroxisome proliferator-activated receptor delta	50282	0.11
chr19_44284831_44285136	0.12	KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	426	0.76
chr10_60580536_60580825	0.12	BICC1	bicaudal C homolog 1 (Drosophila)	27385	0.23
chr13_102068554_102068730	0.12	NALCN	sodium leak channel, non-selective	64	0.98
chr5_374526_374728	0.12	AHRR	aryl-hydrocarbon receptor repressor	30984	0.14
chr1_110599711_110600002	0.12	RP4-773N10.4		1106	0.39
chr10_128595169_128595405	0.12	DOCK1	dedicator of cytokinesis 1	1309	0.52
chr1_210424867_210425148	0.12	SERTAD4-AS1	SERTAD4 antisense RNA 1	17615	0.21
chr15_74724718_74725429	0.12	SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	928	0.5
chr19_677691_677842	0.12	FSTL3	follistatin-like 3 (secreted glycoprotein)	176	0.9
chr1_152758757_152758908	0.12	LCE1E	late cornified envelope 1E	79	0.94
chr10_3806458_3806609	0.12	RP11-184A2.2		3574	0.26
chr1_159171046_159171197	0.12	CTA-134P22.2		1181	0.37
chr12_41286154_41286409	0.12	CNTN1	contactin 1	15875	0.3
chr1_156630677_156631393	0.12	RP11-284F21.7		181	0.89
chr15_65714510_65715080	0.12	IGDCC4	immunoglobulin superfamily, DCC subclass, member 4	615	0.71
chr11_63530349_63531105	0.12	ENSG00000264519	.	34816	0.12
chr6_15505544_15505788	0.12	DTNBP1	dystrobrevin binding protein 1	42927	0.19
chr5_37839467_37839691	0.12	GDNF	glial cell derived neurotrophic factor	203	0.96
chr3_62859805_62860096	0.12	CADPS	Ca++-dependent secretion activator	754	0.75
chr15_75953728_75953957	0.12	SNX33	sorting nexin 33	11745	0.09
chr17_79013898_79014087	0.12	BAIAP2	BAI1-associated protein 2	4189	0.15
chr20_36846491_36846985	0.12	KIAA1755	KIAA1755	8883	0.19
chr1_154786244_154786395	0.12	KCNN3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	46000	0.11
chr4_182470597_182470748	0.12	ENSG00000251742	.	285589	0.01
chr1_2141310_2141461	0.12	AL590822.1	Uncharacterized protein	4235	0.14
chr1_12675825_12676469	0.12	DHRS3	dehydrogenase/reductase (SDR family) member 3	1590	0.37
chr3_49577030_49577181	0.12	BSN	bassoon presynaptic cytomatrix protein	14817	0.15
chr4_55093927_55094291	0.11	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	1155	0.61
chr2_236574591_236575244	0.11	AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	3331	0.35
chr14_75077914_75078284	0.11	LTBP2	latent transforming growth factor beta binding protein 2	676	0.71
chr8_69242814_69243988	0.11	C8orf34	chromosome 8 open reading frame 34	56	0.82
chr8_124550438_124550806	0.11	FBXO32	F-box protein 32	2824	0.28
chr2_97636030_97636181	0.11	ENSG00000238760	.	11016	0.14
chr8_54794434_54794715	0.11	RGS20	regulator of G-protein signaling 20	1120	0.49
chr15_75092311_75092506	0.11	CSK	c-src tyrosine kinase	2153	0.19
chr20_60930372_60930523	0.11	RP11-157P1.5		2378	0.19
chr20_35170676_35170845	0.11	MYL9	myosin, light chain 9, regulatory	860	0.53
chr9_71939475_71940274	0.11	FAM189A2	family with sequence similarity 189, member A2	386	0.91
chr11_122071962_122072152	0.11	ENSG00000207994	.	49041	0.12
chr2_220139020_220139392	0.11	TUBA4A	tubulin, alpha 4a	3392	0.09
chr13_111040556_111041009	0.11	ENSG00000238629	.	25770	0.2
chr7_145093241_145093392	0.11	ENSG00000200673	.	546139	0.0
chr6_143995099_143995343	0.11	PHACTR2	phosphatase and actin regulator 2	3881	0.32
chr19_4374282_4374693	0.11	SH3GL1	SH3-domain GRB2-like 1	5802	0.08
chr1_16481335_16481929	0.11	RP11-276H7.2		74	0.93
chr17_18281005_18281222	0.11	EVPLL	envoplakin-like	137	0.93
chr3_40428700_40429091	0.11	ENTPD3	ectonucleoside triphosphate diphosphohydrolase 3	159	0.96
chr16_811279_811430	0.11	MSLN	mesothelin	256	0.77
chr1_16508264_16508425	0.11	ARHGEF19-AS1	ARHGEF19 antisense RNA 1	16005	0.1
chr22_43005089_43005553	0.11	POLDIP3	polymerase (DNA-directed), delta interacting protein 3	5542	0.12
chr19_20150080_20150295	0.11	ZNF682	zinc finger protein 682	65	0.97
chrX_68063428_68063579	0.11	EFNB1	ephrin-B1	14663	0.3
chr2_95742439_95743056	0.11	AC103563.9		23826	0.15
chr1_98518942_98519575	0.11	ENSG00000225206	.	7531	0.32
chr11_70962306_70962531	0.11	SHANK2	SH3 and multiple ankyrin repeat domains 2	1205	0.6
chr20_48989140_48989291	0.11	ENSG00000244376	.	56805	0.13
chr20_45141972_45142630	0.11	ZNF334	zinc finger protein 334	103	0.97

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFCP2L1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1	0.2	GO:0071504	cellular response to heparin(GO:0071504)
0.1	0.3	GO:1900078	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.1	0.3	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.1	0.2	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.2	GO:0070141	response to UV-A(GO:0070141)
0.0	0.2	GO:0033088	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.2	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.2	GO:1901889	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.0	GO:0072239	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0	0.1	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0045945	positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0	0.1	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.2	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.0	GO:0003148	outflow tract septum morphogenesis(GO:0003148)
0.0	0.0	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0071800	podosome assembly(GO:0071800)
0.0	0.3	GO:0043616	keratinocyte proliferation(GO:0043616)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0060753	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0045605	negative regulation of epidermal cell differentiation(GO:0045605)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0032224	positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.1	GO:0032801	receptor catabolic process(GO:0032801)
0.0	0.1	GO:0048799	organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.0	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0072179	mesonephric tubule formation(GO:0072172) nephric duct formation(GO:0072179)
0.0	0.0	GO:0061430	bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0	0.0	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.0	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.0	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0002090	regulation of receptor internalization(GO:0002090)
0.0	0.1	GO:0031529	ruffle organization(GO:0031529)
0.0	0.1	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.0	GO:0003283	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.0	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.0	GO:0046449	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.0	GO:0043276	anoikis(GO:0043276)
0.0	0.1	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.0	GO:0003181	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.1	GO:0046415	urate metabolic process(GO:0046415)
0.0	0.0	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.0	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.0	GO:0033024	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.0	GO:0022011	Schwann cell development(GO:0014044) myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0010324	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.0	GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.2	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:1901890	positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0	0.0	GO:0043301	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.0	GO:0048752	semicircular canal morphogenesis(GO:0048752)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0031045	dense core granule(GO:0031045)
0.0	0.0	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.3	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0031904	endosome lumen(GO:0031904)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.0	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.1	GO:0090568	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.2	GO:0034706	sodium channel complex(GO:0034706)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.2	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.3	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.2	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.2	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.2	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.1	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.2	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.2	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.2	GO:0048185	activin binding(GO:0048185)
0.0	0.2	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.0	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.0	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.2	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.3	GO:0005326	neurotransmitter transporter activity(GO:0005326)
0.0	0.1	GO:0015333	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.0	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0005497	androgen binding(GO:0005497)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.0	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.0	0.1	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.0	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.0	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.2	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.0	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.4	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.7	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.0	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.4	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.0	REACTOME FRS2 MEDIATED CASCADE	Genes involved in FRS2-mediated cascade
0.0	0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.2	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.2	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.0	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.1	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling