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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for TFCP2L1

Z-value: 0.61

Motif logo

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Transcription factors associated with TFCP2L1

Gene Symbol Gene ID Gene Info
TFCP2L1
ENSG00000115112.7 transcription factor CP2 like 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr2_122030038_122030189TFCP2L1126700.2912670.809.3e-03Click!
chr2_121969092_121969243TFCP2L1736160.1188020.781.3e-02Click!
chr2_121943565_121943716TFCP2L1991430.0785770.742.3e-02Click!
chr2_122040725_122040876TFCP2L119830.4734340.684.3e-02Click!
chr2_122030438_122030589TFCP2L1122700.2923700.665.3e-02Click!

Activity of the TFCP2L1 motif across conditions

Conditions sorted by the z-value of the TFCP2L1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_2143838_2144077 0.40 ENSG00000207805
 .
 11482
 0.11
chr17_73718374_73718525 0.33 ITGB4
 integrin, beta 4
 872
 0.43
chr1_172360185_172360576 0.32 DNM3
 dynamin 3
 12222
 0.16
chr20_55204347_55205219 0.32 TFAP2C
 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
 425
 0.81
chr21_44753087_44753381 0.31 SIK1
 salt-inducible kinase 1
 93774
 0.08
chr2_227660537_227660688 0.29 IRS1
 insulin receptor substrate 1
 3863
 0.25
chr14_105332811_105333071 0.28 CEP170B
 centrosomal protein 170B
 1287
 0.43
chr11_131780111_131780399 0.27 NTM
 neurotrimin
 642
 0.77
chr12_54391177_54391923 0.26 HOXC-AS2
 HOXC cluster antisense RNA 2
 981
 0.22
chr5_2752991_2753357 0.26 C5orf38
 chromosome 5 open reading frame 38
 795
 0.6
chr11_76495400_76495579 0.26 TSKU
 tsukushi, small leucine rich proteoglycan
 297
 0.83
chr16_765872_766413 0.26 METRN
 meteorin, glial cell differentiation regulator
 432
 0.55
chr21_46891372_46891858 0.25 COL18A1
 collagen, type XVIII, alpha 1
 16191
 0.18
chr1_110693132_110693795 0.25 SLC6A17
 solute carrier family 6 (neutral amino acid transporter), member 17
 355
 0.81
chr5_167646669_167646982 0.24 CTB-178M22.2
12537
 0.22
chr1_27189686_27189837 0.24 SFN
 stratifin
 128
 0.93
chr20_61467867_61468113 0.23 COL9A3
 collagen, type IX, alpha 3
 18827
 0.11
chr2_227661089_227661317 0.23 IRS1
 insulin receptor substrate 1
 3272
 0.26
chr12_6484544_6484695 0.23 LTBR
 lymphotoxin beta receptor (TNFR superfamily, member 3)
 24
 0.57
chr11_1896066_1896383 0.22 LSP1
 lymphocyte-specific protein 1
 1483
 0.24
chrX_48916544_48916695 0.22 CCDC120
 coiled-coil domain containing 120
 73
 0.94
chr8_42356526_42357223 0.21 SLC20A2
 solute carrier family 20 (phosphate transporter), member 2
 1887
 0.34
chr22_36461534_36461685 0.21 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 37136
 0.19
chr12_113859774_113860410 0.21 SDSL
 serine dehydratase-like
 50
 0.97
chr12_52540782_52540933 0.21 ENSG00000265804
 .
 33148
 0.09
chr16_89630259_89630469 0.21 RPL13
 ribosomal protein L13
 1586
 0.22
chr17_75282403_75282641 0.21 SEPT9
 septin 9
 1451
 0.48
chr10_73758338_73758489 0.20 CHST3
 carbohydrate (chondroitin 6) sulfotransferase 3
 34290
 0.18
chr1_32045069_32045220 0.20 TINAGL1
 tubulointerstitial nephritis antigen-like 1
 3005
 0.19
chr3_50193036_50193699 0.20 RP11-493K19.3
86
 0.87
chr11_1858026_1858177 0.20 SYT8
 synaptotagmin VIII
 2067
 0.16
chr11_122049732_122050124 0.20 ENSG00000207994
 .
 26912
 0.16
chr3_46428014_46428165 0.20 CCR5
 chemokine (C-C motif) receptor 5 (gene/pseudogene)
 13928
 0.14
chr5_150968827_150968978 0.20 FAT2
 FAT atypical cadherin 2
 20397
 0.17
chr18_11689181_11689508 0.20 GNAL
 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
 389
 0.89
chr9_132429402_132429765 0.19 PRRX2
 paired related homeobox 2
 1663
 0.28
chr5_135527631_135527866 0.19 TRPC7-AS1
 TRPC7 antisense RNA 1
 21988
 0.18
chr5_131593477_131594185 0.19 PDLIM4
 PDZ and LIM domain 4
 431
 0.81
chr20_33759810_33760395 0.19 PROCR
 protein C receptor, endothelial
 226
 0.9
chr6_16056248_16056399 0.19 MYLIP
 myosin regulatory light chain interacting protein
 73033
 0.1
chr18_77938309_77938600 0.19 AC139100.3
3109
 0.25
chr8_144896706_144897508 0.19 SCRIB
 scribbled planar cell polarity protein
 31
 0.94
chr17_878729_878960 0.18 NXN
 nucleoredoxin
 4166
 0.16
chr2_219858277_219858732 0.18 CRYBA2
 crystallin, beta A2
 361
 0.74
chr22_46980499_46980650 0.18 GRAMD4
 GRAM domain containing 4
 7548
 0.22
chr2_238804740_238804891 0.18 ENSG00000263723
 .
 26268
 0.17
chr7_150814571_150814722 0.18 AGAP3
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
 650
 0.56
chr13_114524710_114524921 0.18 GAS6-AS1
 GAS6 antisense RNA 1
 6212
 0.22
chr4_187491209_187491867 0.17 MTNR1A
 melatonin receptor 1A
 14817
 0.17
chr16_75299159_75299651 0.17 BCAR1
 breast cancer anti-estrogen resistance 1
 292
 0.87
chr11_34642741_34642892 0.17 EHF
 ets homologous factor
 134
 0.98
chr10_64324269_64324457 0.17 ZNF365
 zinc finger protein 365
 44156
 0.18
chr12_116563914_116564400 0.17 ENSG00000207967
 .
 22302
 0.2
chr14_105436556_105437076 0.16 AHNAK2
 AHNAK nucleoprotein 2
 7878
 0.16
chr2_150186573_150186784 0.16 LYPD6
 LY6/PLAUR domain containing 6
 179
 0.97
chr2_86444196_86444456 0.16 MRPL35
 mitochondrial ribosomal protein L35
 17740
 0.12
chr22_37823258_37823437 0.16 RP1-63G5.5
133
 0.53
chr4_190731965_190732231 0.16 ENSG00000266024
 .
 7725
 0.28
chr17_6459033_6459314 0.16 PITPNM3
 PITPNM family member 3
 607
 0.7
chr19_17953136_17953665 0.16 JAK3
 Janus kinase 3
 1856
 0.22
chr4_20256302_20256578 0.16 SLIT2
 slit homolog 2 (Drosophila)
 103
 0.98
chr7_100876080_100876231 0.16 CLDN15
 claudin 15
 4886
 0.11
chrX_11682905_11683408 0.16 ARHGAP6
 Rho GTPase activating protein 6
 208
 0.97
chr15_37402857_37403086 0.16 MEIS2
 Meis homeobox 2
 9467
 0.23
chr5_131561351_131561783 0.16 P4HA2
 prolyl 4-hydroxylase, alpha polypeptide II
 1368
 0.4
chr5_61212914_61213065 0.16 RP11-2O17.2
218730
 0.02
chr6_13761461_13761614 0.15 MCUR1
 mitochondrial calcium uniporter regulator 1
 40040
 0.15
chr4_62067754_62067905 0.15 LPHN3
 latrophilin 3
 31
 0.99
chr2_225905702_225906810 0.15 DOCK10
 dedicator of cytokinesis 10
 903
 0.7
chr1_44030641_44030792 0.15 PTPRF
 protein tyrosine phosphatase, receptor type, F
 19969
 0.18
chr1_149908531_149908774 0.15 MTMR11
 myotubularin related protein 11
 139
 0.92
chr10_61469364_61469637 0.15 SLC16A9
 solute carrier family 16, member 9
 337
 0.94
chr14_55151103_55151261 0.15 SAMD4A
 sterile alpha motif domain containing 4A
 70369
 0.12
chr4_152462150_152462592 0.15 FAM160A1
 family with sequence similarity 160, member A1
 8207
 0.21
chr1_206685419_206685570 0.15 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 4615
 0.16
chr6_75911985_75912746 0.15 COL12A1
 collagen, type XII, alpha 1
 143
 0.97
chr9_116356768_116357019 0.15 RGS3
 regulator of G-protein signaling 3
 1127
 0.54
chr17_66596391_66596729 0.15 FAM20A
 family with sequence similarity 20, member A
 970
 0.63
chr2_69238294_69238445 0.15 ANTXR1
 anthrax toxin receptor 1
 1941
 0.36
chr8_145023500_145024036 0.15 PLEC
 plectin
 1276
 0.29
chr1_38100032_38100233 0.15 RSPO1
 R-spondin 1
 156
 0.94
chr1_3382753_3382904 0.15 ARHGEF16
 Rho guanine nucleotide exchange factor (GEF) 16
 259
 0.93
chr1_192776419_192777001 0.15 RGS2
 regulator of G-protein signaling 2, 24kDa
 1461
 0.52
chr4_77561461_77561612 0.15 AC107072.2
2760
 0.3
chr11_7273101_7273359 0.14 SYT9
 synaptotagmin IX
 49
 0.98
chr3_9745623_9746706 0.14 CPNE9
 copine family member IX
 654
 0.62
chr5_98113748_98113899 0.14 RGMB
 repulsive guidance molecule family member b
 4484
 0.25
chr4_2066511_2066662 0.14 NAT8L
 N-acetyltransferase 8-like (GCN5-related, putative)
 5047
 0.17
chr1_220906357_220906642 0.14 MARC2
 mitochondrial amidoxime reducing component 2
 15112
 0.19
chr11_66104634_66104935 0.14 RIN1
 Ras and Rab interactor 1
 473
 0.54
chr19_12305803_12306072 0.14 ZNF136
 zinc finger protein 136
 32006
 0.1
chr7_127911991_127912224 0.14 ENSG00000221429
 .
 17950
 0.16
chr3_117715779_117716482 0.14 LSAMP
 limbic system-associated membrane protein
 35
 0.99
chr2_241374262_241374834 0.14 GPC1
 glypican 1
 540
 0.75
chr8_94713195_94713677 0.14 FAM92A1
 family with sequence similarity 92, member A1
 326
 0.7
chr4_10097453_10097846 0.14 ENSG00000264931
 .
 17333
 0.14
chr17_38334308_38334459 0.14 RAPGEFL1
 Rap guanine nucleotide exchange factor (GEF)-like 1
 118
 0.95
chr9_35792725_35792965 0.14 NPR2
 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
 694
 0.46
chr17_74023240_74023391 0.14 EVPL
 envoplakin
 3
 0.96
chrX_118533808_118534027 0.14 SLC25A43
 solute carrier family 25, member 43
 574
 0.64
chr3_184258855_184259006 0.14 EIF2B5-AS1
 EIF2B5 antisense RNA 1
 15776
 0.17
chr17_55950685_55950914 0.14 CUEDC1
 CUE domain containing 1
 768
 0.63
chr3_126725554_126725705 0.14 PLXNA1
 plexin A1
 18192
 0.27
chr8_143869634_143869785 0.14 LY6D
 lymphocyte antigen 6 complex, locus D
 1701
 0.2
chr20_61002159_61002310 0.14 RBBP8NL
 RBBP8 N-terminal like
 355
 0.83
chr5_9544908_9545592 0.14 SEMA5A
 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
 937
 0.56
chr6_3455960_3456202 0.14 SLC22A23
 solute carrier family 22, member 23
 196
 0.97
chr17_15686261_15686502 0.14 ENSG00000251829
 .
 726
 0.64
chr10_127942305_127942518 0.14 ENSG00000222740
 .
 108260
 0.07
chr2_28659437_28659588 0.13 PLB1
 phospholipase B1
 20500
 0.17
chr2_121943565_121943716 0.13 TFCP2L1
 transcription factor CP2-like 1
 99143
 0.08
chr9_85927301_85927452 0.13 FRMD3
 FERM domain containing 3
 495
 0.81
chr1_212415011_212415162 0.13 PPP2R5A
 protein phosphatase 2, regulatory subunit B', alpha
 43793
 0.13
chr15_91500342_91500803 0.13 RCCD1
 RCC1 domain containing 1
 1546
 0.18
chr9_90812890_90813286 0.13 ENSG00000252299
 .
 176096
 0.03
chr17_48133472_48134260 0.13 ITGA3
 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
 62
 0.96
chr17_5025740_5025978 0.13 ZNF232
 zinc finger protein 232
 538
 0.63
chr14_89506858_89507416 0.13 FOXN3
 forkhead box N3
 139951
 0.05
chr16_87241382_87241645 0.13 RP11-899L11.3
8008
 0.23
chr12_59309288_59309823 0.13 LRIG3
 leucine-rich repeats and immunoglobulin-like domains 3
 1191
 0.55
chr20_30557048_30557199 0.13 XKR7
 XK, Kell blood group complex subunit-related family, member 7
 1318
 0.34
chr17_37856067_37857084 0.13 ERBB2
 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
 242
 0.86
chr11_392408_392559 0.13 PKP3
 plakophilin 3
 131
 0.92
chr17_4902045_4902282 0.13 KIF1C
 kinesin family member 1C
 914
 0.26
chr9_98980169_98980538 0.13 ENSG00000265367
 .
 17851
 0.18
chr9_130330127_130331202 0.13 FAM129B
 family with sequence similarity 129, member B
 703
 0.67
chr7_55120970_55121121 0.13 EGFR
 epidermal growth factor receptor
 34234
 0.22
chr2_175206758_175207367 0.13 AC018470.1
 Uncharacterized protein FLJ46347
 4911
 0.18
chr17_11143475_11144119 0.13 SHISA6
 shisa family member 6
 783
 0.71
chr2_239776059_239776362 0.13 TWIST2
 twist family bHLH transcription factor 2
 19537
 0.23
chr2_153399155_153399498 0.13 FMNL2
 formin-like 2
 76766
 0.12
chr11_47561392_47561727 0.13 CELF1
 CUGBP, Elav-like family member 1
 13110
 0.08
chr18_59666418_59666569 0.13 RNF152
 ring finger protein 152
 105029
 0.07
chr2_151342010_151342200 0.12 RND3
 Rho family GTPase 3
 209
 0.97
chr7_101796468_101796619 0.12 ENSG00000252824
 .
 40901
 0.15
chr11_19585849_19586032 0.12 ENSG00000265210
 .
 10917
 0.19
chr2_219081816_219081967 0.12 ARPC2
 actin related protein 2/3 complex, subunit 2, 34kDa
 27
 0.96
chr17_72426935_72427098 0.12 GPRC5C
 G protein-coupled receptor, family C, group 5, member C
 36
 0.97
chr21_37850808_37851450 0.12 CLDN14
 claudin 14
 1259
 0.42
chr10_73060971_73061122 0.12 SLC29A3
 solute carrier family 29 (equilibrative nucleoside transporter), member 3
 17969
 0.18
chr8_494094_494251 0.12 TDRP
 testis development related protein
 665
 0.79
chrX_56829451_56830094 0.12 ENSG00000204272
 .
 74080
 0.12
chr6_35360609_35360760 0.12 PPARD
 peroxisome proliferator-activated receptor delta
 50282
 0.11
chr19_44284831_44285136 0.12 KCNN4
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
 426
 0.76
chr10_60580536_60580825 0.12 BICC1
 bicaudal C homolog 1 (Drosophila)
 27385
 0.23
chr13_102068554_102068730 0.12 NALCN
 sodium leak channel, non-selective
 64
 0.98
chr5_374526_374728 0.12 AHRR
 aryl-hydrocarbon receptor repressor
 30984
 0.14
chr1_110599711_110600002 0.12 RP4-773N10.4
1106
 0.39
chr10_128595169_128595405 0.12 DOCK1
 dedicator of cytokinesis 1
 1309
 0.52
chr1_210424867_210425148 0.12 SERTAD4-AS1
 SERTAD4 antisense RNA 1
 17615
 0.21
chr15_74724718_74725429 0.12 SEMA7A
 semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
 928
 0.5
chr19_677691_677842 0.12 FSTL3
 follistatin-like 3 (secreted glycoprotein)
 176
 0.9
chr1_152758757_152758908 0.12 LCE1E
 late cornified envelope 1E
 79
 0.94
chr10_3806458_3806609 0.12 RP11-184A2.2
3574
 0.26
chr1_159171046_159171197 0.12 CTA-134P22.2
1181
 0.37
chr12_41286154_41286409 0.12 CNTN1
 contactin 1
 15875
 0.3
chr1_156630677_156631393 0.12 RP11-284F21.7
181
 0.89
chr15_65714510_65715080 0.12 IGDCC4
 immunoglobulin superfamily, DCC subclass, member 4
 615
 0.71
chr11_63530349_63531105 0.12 ENSG00000264519
 .
 34816
 0.12
chr6_15505544_15505788 0.12 DTNBP1
 dystrobrevin binding protein 1
 42927
 0.19
chr5_37839467_37839691 0.12 GDNF
 glial cell derived neurotrophic factor
 203
 0.96
chr3_62859805_62860096 0.12 CADPS
 Ca++-dependent secretion activator
 754
 0.75
chr15_75953728_75953957 0.12 SNX33
 sorting nexin 33
 11745
 0.09
chr17_79013898_79014087 0.12 BAIAP2
 BAI1-associated protein 2
 4189
 0.15
chr20_36846491_36846985 0.12 KIAA1755
 KIAA1755
 8883
 0.19
chr1_154786244_154786395 0.12 KCNN3
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
 46000
 0.11
chr4_182470597_182470748 0.12 ENSG00000251742
 .
 285589
 0.01
chr1_2141310_2141461 0.12 AL590822.1
 Uncharacterized protein
 4235
 0.14
chr1_12675825_12676469 0.12 DHRS3
 dehydrogenase/reductase (SDR family) member 3
 1590
 0.37
chr3_49577030_49577181 0.12 BSN
 bassoon presynaptic cytomatrix protein
 14817
 0.15
chr4_55093927_55094291 0.11 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
 1155
 0.61
chr2_236574591_236575244 0.11 AGAP1
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
 3331
 0.35
chr14_75077914_75078284 0.11 LTBP2
 latent transforming growth factor beta binding protein 2
 676
 0.71
chr8_69242814_69243988 0.11 C8orf34
 chromosome 8 open reading frame 34
 56
 0.82
chr8_124550438_124550806 0.11 FBXO32
 F-box protein 32
 2824
 0.28
chr2_97636030_97636181 0.11 ENSG00000238760
 .
 11016
 0.14
chr8_54794434_54794715 0.11 RGS20
 regulator of G-protein signaling 20
 1120
 0.49
chr15_75092311_75092506 0.11 CSK
 c-src tyrosine kinase
 2153
 0.19
chr20_60930372_60930523 0.11 RP11-157P1.5
2378
 0.19
chr20_35170676_35170845 0.11 MYL9
 myosin, light chain 9, regulatory
 860
 0.53
chr9_71939475_71940274 0.11 FAM189A2
 family with sequence similarity 189, member A2
 386
 0.91
chr11_122071962_122072152 0.11 ENSG00000207994
 .
 49041
 0.12
chr2_220139020_220139392 0.11 TUBA4A
 tubulin, alpha 4a
 3392
 0.09
chr13_111040556_111041009 0.11 ENSG00000238629
 .
 25770
 0.2
chr7_145093241_145093392 0.11 ENSG00000200673
 .
 546139
 0.0
chr6_143995099_143995343 0.11 PHACTR2
 phosphatase and actin regulator 2
 3881
 0.32
chr19_4374282_4374693 0.11 SH3GL1
 SH3-domain GRB2-like 1
 5802
 0.08
chr1_16481335_16481929 0.11 RP11-276H7.2
74
 0.93
chr17_18281005_18281222 0.11 EVPLL
 envoplakin-like
 137
 0.93
chr3_40428700_40429091 0.11 ENTPD3
 ectonucleoside triphosphate diphosphohydrolase 3
 159
 0.96
chr16_811279_811430 0.11 MSLN
 mesothelin
 256
 0.77
chr1_16508264_16508425 0.11 ARHGEF19-AS1
 ARHGEF19 antisense RNA 1
 16005
 0.1
chr22_43005089_43005553 0.11 POLDIP3
 polymerase (DNA-directed), delta interacting protein 3
 5542
 0.12
chr19_20150080_20150295 0.11 ZNF682
 zinc finger protein 682
 65
 0.97
chrX_68063428_68063579 0.11 EFNB1
 ephrin-B1
 14663
 0.3
chr2_95742439_95743056 0.11 AC103563.9
23826
 0.15
chr1_98518942_98519575 0.11 ENSG00000225206
 .
 7531
 0.32
chr11_70962306_70962531 0.11 SHANK2
 SH3 and multiple ankyrin repeat domains 2
 1205
 0.6
chr20_48989140_48989291 0.11 ENSG00000244376
 .
 56805
 0.13
chr20_45141972_45142630 0.11 ZNF334
 zinc finger protein 334
 103
 0.97

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of TFCP2L1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 0.2 GO:0071504 cellular response to heparin(GO:0071504)
0.1 0.3 GO:1900078 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.1 0.3 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.1 0.2 GO:0060676 ureteric bud formation(GO:0060676)
0.0 0.2 GO:0070141 response to UV-A(GO:0070141)
0.0 0.2 GO:0033088 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.2 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.2 GO:1901889 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0 0.0 GO:0072239 metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0 0.1 GO:0043129 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.1 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.0 GO:0003148 outflow tract septum morphogenesis(GO:0003148)
0.0 0.0 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0071800 podosome assembly(GO:0071800)
0.0 0.3 GO:0043616 keratinocyte proliferation(GO:0043616)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.1 GO:0045605 negative regulation of epidermal cell differentiation(GO:0045605)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:2000178 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.1 GO:0032801 receptor catabolic process(GO:0032801)
0.0 0.1 GO:0048799 organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0 0.0 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.0 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.0 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.0 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0072179 mesonephric tubule formation(GO:0072172) nephric duct formation(GO:0072179)
0.0 0.0 GO:0061430 bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0 0.0 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.0 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.0 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.1 GO:0002090 regulation of receptor internalization(GO:0002090)
0.0 0.1 GO:0031529 ruffle organization(GO:0031529)
0.0 0.1 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.0 GO:0003283 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.0 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.0 GO:0046449 allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0 0.0 GO:0043276 anoikis(GO:0043276)
0.0 0.1 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.0 GO:0003181 atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0 0.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.0 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.0 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.1 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.1 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.0 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.0 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.0 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0 0.0 GO:0022011 Schwann cell development(GO:0014044) myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0010324 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.0 GO:0003321 positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.2 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:1901890 positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0 0.0 GO:0043301 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.0 GO:0048752 semicircular canal morphogenesis(GO:0048752)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0031045 dense core granule(GO:0031045)
0.0 0.0 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0002178 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0031904 endosome lumen(GO:0031904)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.0 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0090568 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0 0.2 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.2 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.3 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.2 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.2 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0048185 activin binding(GO:0048185)
0.0 0.2 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.0 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.0 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.3 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.1 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.0 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.0 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.1 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.0 0.1 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.0 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.0 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.0 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.0 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.0 GO:0008061 chitin binding(GO:0008061)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.0 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.0 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.1 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling