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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TFEC_MITF_ARNTL_BHLHE41

Z-value: 0.59

Motif logo

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Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41

Gene Symbol Gene ID Gene Info
TFEC
ENSG00000105967.11 TFEC
MITF
ENSG00000187098.10 MITF
ARNTL
ENSG00000133794.13 ARNTL
BHLHE41
ENSG00000123095.5 BHLHE41

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
ARNTLchr11_13299425_133000042820.9448680.835.9e-03Click!
ARNTLchr11_13326042_1332619354160.2848190.665.1e-02Click!
ARNTLchr11_13298200_132989923970.9082740.646.4e-02Click!
ARNTLchr11_13300075_133006379240.6995820.617.9e-02Click!
ARNTLchr11_13238316_13238540597710.1465910.618.3e-02Click!
BHLHE41chr12_26278317_262786974470.5023050.452.3e-01Click!
BHLHE41chr12_26276607_2627696912720.3494420.324.1e-01Click!
BHLHE41chr12_26277242_262780534130.7580930.215.9e-01Click!
MITFchr3_69887353_69887504279350.2202120.826.2e-03Click!
MITFchr3_69814122_6981427312350.533827-0.674.9e-02Click!
MITFchr3_69811560_698118071920.9589540.531.4e-01Click!
MITFchr3_69788021_697883883820.9040110.442.4e-01Click!
MITFchr3_69698932_69699083895790.089060-0.422.5e-01Click!
TFECchr7_115668295_11566844624250.430817-0.627.3e-02Click!
TFECchr7_115816578_115816729167030.2132790.561.2e-01Click!
TFECchr7_115806435_11580658665600.2554450.462.1e-01Click!
TFECchr7_115668575_11566872621450.458726-0.452.3e-01Click!
TFECchr7_115665548_11566569951720.3329380.442.4e-01Click!

Activity of the TFEC_MITF_ARNTL_BHLHE41 motif across conditions

Conditions sorted by the z-value of the TFEC_MITF_ARNTL_BHLHE41 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_202896403_202896578 0.30 KLHL12
 kelch-like family member 12
 100
 0.95
chr19_4402510_4402661 0.29 CHAF1A
 chromatin assembly factor 1, subunit A (p150)
 74
 0.93
chr3_19988451_19988692 0.27 RAB5A
 RAB5A, member RAS oncogene family
 0
 0.54
chr1_154531335_154531531 0.25 UBE2Q1
 ubiquitin-conjugating enzyme E2Q family member 1
 324
 0.81
chr20_61315156_61315307 0.21 SLCO4A1
 solute carrier organic anion transporter family, member 4A1
 16066
 0.11
chr6_15897253_15897404 0.21 MYLIP
 myosin regulatory light chain interacting protein
 232028
 0.02
chr17_46646430_46646725 0.21 HOXB3
 homeobox B3
 4808
 0.08
chr19_10764777_10764928 0.20 ILF3
 interleukin enhancer binding factor 3, 90kDa
 85
 0.95
chr2_6868388_6868539 0.19 AC017076.5
105199
 0.07
chr2_202987834_202988283 0.19 AC079354.3
6277
 0.17
chr9_96793015_96793166 0.19 PTPDC1
 protein tyrosine phosphatase domain containing 1
 14
 0.99
chr1_27855501_27855753 0.18 RP1-159A19.4
3311
 0.23
chr17_39472322_39472473 0.18 KRTAP17-1
 keratin associated protein 17-1
 450
 0.64
chr10_135073626_135073923 0.18 MIR202HG
 MIR202 host gene (non-protein coding)
 12379
 0.1
chr11_63706516_63706697 0.17 NAA40
 N(alpha)-acetyltransferase 40, NatD catalytic subunit
 114
 0.94
chr17_32906311_32906556 0.17 C17orf102
 chromosome 17 open reading frame 102
 45
 0.97
chr22_40406174_40406325 0.17 FAM83F
 family with sequence similarity 83, member F
 557
 0.75
chr13_49684124_49684410 0.17 FNDC3A
 fibronectin type III domain containing 3A
 182
 0.96
chr10_70480705_70480856 0.16 CCAR1
 cell division cycle and apoptosis regulator 1
 11
 0.97
chrX_102631036_102631748 0.16 NGFRAP1
 nerve growth factor receptor (TNFRSF16) associated protein 1
 57
 0.97
chr17_37271305_37271492 0.16 PLXDC1
 plexin domain containing 1
 7658
 0.16
chr9_126088906_126089175 0.15 CRB2
 crumbs homolog 2 (Drosophila)
 29409
 0.19
chr2_126229593_126229744 0.15 ENSG00000201853
 .
 343259
 0.01
chr7_644134_644285 0.15 AC147651.4
1387
 0.35
chr12_90103095_90103246 0.15 ATP2B1
 ATPase, Ca++ transporting, plasma membrane 1
 93
 0.97
chr8_28259515_28259714 0.15 ZNF395
 zinc finger protein 395
 604
 0.66
chr13_52377985_52378296 0.14 DHRS12
 dehydrogenase/reductase (SDR family) member 12
 94
 0.76
chr15_63322236_63322431 0.14 TPM1
 tropomyosin 1 (alpha)
 12498
 0.18
chr1_154193354_154193505 0.14 UBAP2L
 ubiquitin associated protein 2-like
 6
 0.81
chr14_62004309_62004586 0.14 RP11-47I22.1
7558
 0.2
chr3_184078420_184078571 0.14 CLCN2
 chloride channel, voltage-sensitive 2
 895
 0.31
chr7_150065813_150066064 0.14 REPIN1
 replication initiator 1
 22
 0.52
chr12_133262106_133262374 0.14 POLE
 polymerase (DNA directed), epsilon, catalytic subunit
 1674
 0.22
chr19_47200473_47200624 0.14 ENSG00000243560
 .
 8223
 0.09
chr19_5681089_5681249 0.14 HSD11B1L
 hydroxysteroid (11-beta) dehydrogenase 1-like
 1
 0.44
chr9_98075387_98075786 0.13 FANCC
 Fanconi anemia, complementation group C
 3590
 0.32
chr12_85305306_85305778 0.13 SLC6A15
 solute carrier family 6 (neutral amino acid transporter), member 15
 261
 0.96
chr10_22609853_22610108 0.13 BMI1
 BMI1 polycomb ring finger oncogene
 160
 0.94
chr17_79377761_79377965 0.13 ENSG00000266392
 .
 3285
 0.14
chr10_104223217_104223368 0.13 TMEM180
 transmembrane protein 180
 2122
 0.16
chr5_139782206_139782432 0.13 ANKHD1
 ankyrin repeat and KH domain containing 1
 813
 0.3
chr19_35939103_35939363 0.13 FFAR2
 free fatty acid receptor 2
 30
 0.96
chr10_3822916_3823697 0.13 KLF6
 Kruppel-like factor 6
 4079
 0.25
chr5_343263_343474 0.13 AHRR
 aryl-hydrocarbon receptor repressor
 275
 0.91
chr17_37910917_37911166 0.13 GRB7
 growth factor receptor-bound protein 7
 12536
 0.11
chr5_132759480_132759652 0.13 ENSG00000221287
 .
 3832
 0.29
chr9_98278987_98279233 0.13 PTCH1
 patched 1
 137
 0.95
chr13_102106282_102106433 0.13 ITGBL1
 integrin, beta-like 1 (with EGF-like repeat domains)
 1339
 0.56
chr1_40283034_40283198 0.13 RP1-118J21.25
28468
 0.11
chr10_14050350_14050950 0.13 FRMD4A
 FERM domain containing 4A
 118
 0.97
chr19_10835608_10835759 0.13 DNM2
 dynamin 2
 6446
 0.12
chr3_158519414_158519896 0.12 MFSD1
 major facilitator superfamily domain containing 1
 1
 0.54
chr1_11866221_11866477 0.12 CLCN6
 chloride channel, voltage-sensitive 6
 32
 0.74
chr4_148604275_148604426 0.12 PRMT10
 protein arginine methyltransferase 10 (putative)
 926
 0.6
chr10_711598_711749 0.12 RP11-809C18.5
2175
 0.26
chr17_21156722_21156881 0.12 C17orf103
 chromosome 17 open reading frame 103
 79
 0.97
chr17_39261264_39261415 0.12 KRTAP4-9
 keratin associated protein 4-9
 245
 0.77
chr7_36010887_36011084 0.12 ENSG00000200446
 .
 41111
 0.17
chr10_46090174_46090398 0.12 MARCH8
 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
 68
 0.98
chr17_66201588_66201894 0.12 AMZ2
 archaelysin family metallopeptidase 2
 41974
 0.12
chr1_56942848_56943117 0.12 ENSG00000223307
 .
 99892
 0.08
chrX_72783084_72783245 0.12 CHIC1
 cysteine-rich hydrophobic domain 1
 120
 0.98
chr11_63933058_63933366 0.12 MACROD1
 MACRO domain containing 1
 321
 0.79
chr19_42757596_42757805 0.12 ERF
 Ets2 repressor factor
 351
 0.71
chr16_84401582_84401733 0.12 ATP2C2
 ATPase, Ca++ transporting, type 2C, member 2
 476
 0.82
chr16_29126642_29126901 0.12 CTB-134H23.3
8005
 0.16
chrX_100740137_100740443 0.12 ARMCX4
 armadillo repeat containing, X-linked 4
 2741
 0.23
chr15_31684340_31684641 0.12 KLF13
 Kruppel-like factor 13
 26133
 0.26
chr13_33000514_33000892 0.11 N4BP2L1
 NEDD4 binding protein 2-like 1
 1448
 0.44
chr19_47523477_47523748 0.11 NPAS1
 neuronal PAS domain protein 1
 506
 0.76
chr6_13488651_13488802 0.11 GFOD1
 glucose-fructose oxidoreductase domain containing 1
 832
 0.5
chr9_100684535_100684760 0.11 C9orf156
 chromosome 9 open reading frame 156
 122
 0.95
chr2_160372253_160373306 0.11 ENSG00000207117
 .
 20078
 0.23
chr14_76446267_76446546 0.11 TGFB3
 transforming growth factor, beta 3
 930
 0.62
chr16_28306637_28306788 0.11 SBK1
 SH3 domain binding kinase 1
 2872
 0.28
chr14_72371815_72371966 0.11 RGS6
 regulator of G-protein signaling 6
 27266
 0.24
chr2_223916824_223917105 0.11 KCNE4
 potassium voltage-gated channel, Isk-related family, member 4
 102
 0.98
chr11_66083004_66083200 0.11 CD248
 CD248 molecule, endosialin
 1413
 0.16
chr17_21179296_21179691 0.11 MAP2K3
 mitogen-activated protein kinase kinase 3
 8491
 0.17
chr4_2819558_2819838 0.11 SH3BP2
 SH3-domain binding protein 2
 214
 0.94
chr3_194992441_194992740 0.11 XXYLT1
 xyloside xylosyltransferase 1
 694
 0.66
chr1_224804905_224805156 0.11 CNIH3
 cornichon family AMPA receptor auxiliary protein 3
 1035
 0.41
chr2_234176635_234176786 0.11 ENSG00000252010
 .
 7663
 0.14
chr16_23521764_23521915 0.11 GGA2
 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
 24
 0.97
chr1_154908770_154909108 0.11 PMVK
 phosphomevalonate kinase
 528
 0.6
chr8_145114785_145114936 0.11 OPLAH
 5-oxoprolinase (ATP-hydrolysing)
 724
 0.42
chr1_42921657_42922194 0.11 ZMYND12
 zinc finger, MYND-type containing 12
 13
 0.64
chr2_46131469_46131620 0.11 PRKCE
 protein kinase C, epsilon
 96497
 0.08
chr15_34610151_34611295 0.11 SLC12A6
 solute carrier family 12 (potassium/chloride transporter), member 6
 257
 0.87
chr1_145611013_145611189 0.10 RNF115
 ring finger protein 115
 65
 0.63
chr7_34736_34914 0.10 FAM20C
 family with sequence similarity 20, member C
 158144
 0.04
chr9_117137299_117137450 0.10 AKNA
 AT-hook transcription factor
 1870
 0.36
chr3_126398343_126398521 0.10 TXNRD3
 thioredoxin reductase 3
 24434
 0.17
chr20_61916082_61916233 0.10 ENSG00000266104
 .
 2003
 0.18
chr1_153508703_153508968 0.10 S100A6
 S100 calcium binding protein A6
 115
 0.91
chr1_182138463_182138614 0.10 ZNF648
 zinc finger protein 648
 107691
 0.07
chr6_43970266_43970484 0.10 RP5-1120P11.1
1011
 0.46
chr19_3367067_3367435 0.10 NFIC
 nuclear factor I/C (CCAAT-binding transcription factor)
 667
 0.7
chr11_27744105_27744362 0.10 BDNF
 brain-derived neurotrophic factor
 628
 0.81
chr14_20929873_20930024 0.10 TMEM55B
 transmembrane protein 55B
 177
 0.87
chr6_157469997_157470201 0.10 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 54
 0.98
chr1_6844402_6844649 0.10 RP11-312B8.1
378
 0.72
chr16_66914718_66914914 0.10 PDP2
 pyruvate dehyrogenase phosphatase catalytic subunit 2
 306
 0.82
chr15_72668375_72668880 0.10 HEXA-AS1
 HEXA antisense RNA 1
 173
 0.51
chr6_5026569_5027044 0.10 ENSG00000252419
 .
 19529
 0.19
chr6_13030886_13031149 0.10 PHACTR1
 phosphatase and actin regulator 1
 22672
 0.27
chr22_33096549_33096700 0.10 ENSG00000251890
 .
 65440
 0.11
chr17_58754842_58755035 0.10 BCAS3
 breast carcinoma amplified sequence 3
 124
 0.96
chr2_25149877_25150037 0.10 ADCY3
 adenylate cyclase 3
 7249
 0.18
chr13_80881448_80881599 0.10 SPRY2
 sprouty homolog 2 (Drosophila)
 32271
 0.23
chr18_74499301_74499473 0.10 ENSG00000252097
 .
 13343
 0.21
chr9_132816560_132816877 0.10 GPR107
 G protein-coupled receptor 107
 733
 0.67
chr19_15236279_15236535 0.10 ILVBL
 ilvB (bacterial acetolactate synthase)-like
 63
 0.94
chr6_7672816_7672976 0.10 BMP6
 bone morphogenetic protein 6
 54134
 0.14
chr15_96952055_96952206 0.10 AC087477.1
 Uncharacterized protein
 47643
 0.13
chr2_54862437_54862588 0.10 AC093110.3
27417
 0.18
chr19_42900496_42900647 0.10 LIPE-AS1
 LIPE antisense RNA 1
 709
 0.52
chr6_42017736_42017887 0.10 CCND3
 cyclin D3
 284
 0.63
chr15_75248625_75249054 0.10 RPP25
 ribonuclease P/MRP 25kDa subunit
 115
 0.94
chr16_73749020_73749171 0.10 C16orf47
 chromosome 16 open reading frame 47
 570749
 0.0
chr7_116593207_116593413 0.10 ST7
 suppression of tumorigenicity 7
 18
 0.9
chr22_38851841_38852002 0.10 KCNJ4
 potassium inwardly-rectifying channel, subfamily J, member 4
 716
 0.57
chr4_164471433_164471640 0.10 ENSG00000264535
 .
 27092
 0.19
chr2_172963991_172964212 0.10 DLX2
 distal-less homeobox 2
 3527
 0.26
chr16_66914092_66914355 0.10 PDP2
 pyruvate dehyrogenase phosphatase catalytic subunit 2
 41
 0.95
chr1_7741272_7741423 0.10 CAMTA1
 calmodulin binding transcription activator 1
 55121
 0.13
chr1_8064348_8064644 0.09 ERRFI1
 ERBB receptor feedback inhibitor 1
 11197
 0.18
chr17_47841796_47842381 0.09 FAM117A
 family with sequence similarity 117, member A
 559
 0.72
chr10_50969933_50970461 0.09 OGDHL
 oxoglutarate dehydrogenase-like
 172
 0.97
chr13_38230604_38230755 0.09 POSTN
 periostin, osteoblast specific factor
 57698
 0.16
chr17_68183563_68183714 0.09 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
 17962
 0.2
chr15_44083848_44084237 0.09 SERF2
 small EDRK-rich factor 2
 2
 0.94
chr21_34401153_34401452 0.09 OLIG2
 oligodendrocyte lineage transcription factor 2
 3059
 0.26
chr15_34788505_34788693 0.09 ENSG00000221065
 .
 31973
 0.15
chr17_79455160_79455369 0.09 ENSG00000266077
 .
 22871
 0.08
chr4_120222114_120222265 0.09 C4orf3
 chromosome 4 open reading frame 3
 113
 0.97
chr17_59018713_59018864 0.09 ENSG00000238799
 .
 20466
 0.18
chr17_38708496_38708766 0.09 CCR7
 chemokine (C-C motif) receptor 7
 8634
 0.17
chr9_110495286_110496024 0.09 AL162389.1
 Uncharacterized protein
 44764
 0.15
chr12_80083063_80083495 0.09 PAWR
 PRKC, apoptosis, WT1, regulator
 581
 0.82
chr9_131084429_131084680 0.09 TRUB2
 TruB pseudouridine (psi) synthase family member 2
 57
 0.74
chr2_119981485_119981702 0.09 STEAP3
 STEAP family member 3, metalloreductase
 164
 0.96
chr12_123849561_123849862 0.09 SBNO1
 strawberry notch homolog 1 (Drosophila)
 321
 0.85
chr7_148637539_148638019 0.09 ENSG00000252310
 .
 801
 0.56
chr11_33037172_33037593 0.09 DEPDC7
 DEP domain containing 7
 28
 0.98
chr14_104185073_104185224 0.09 ZFYVE21
 zinc finger, FYVE domain containing 21
 3003
 0.11
chr3_97003394_97003545 0.09 EPHA6
 EPH receptor A6
 155005
 0.04
chr19_35615719_35615873 0.09 FXYD3
 FXYD domain containing ion transport regulator 3
 5529
 0.1
chr12_2185524_2185819 0.09 CACNA1C
 calcium channel, voltage-dependent, L type, alpha 1C subunit
 22942
 0.16
chr15_81316371_81316635 0.09 C15orf26
 chromosome 15 open reading frame 26
 17129
 0.15
chr12_52596811_52596962 0.09 KRT80
 keratin 80
 11102
 0.12
chr17_79031323_79031474 0.09 BAIAP2
 BAI1-associated protein 2
 17
 0.97
chr22_40742852_40743038 0.09 ADSL
 adenylosuccinate lyase
 409
 0.84
chr7_21985259_21985518 0.09 CDCA7L
 cell division cycle associated 7-like
 108
 0.98
chr19_6233769_6234001 0.09 CTC-503J8.4
25283
 0.13
chr11_280052_280224 0.09 NLRP6
 NLR family, pyrin domain containing 6
 1568
 0.17
chr10_29010987_29011704 0.09 ENSG00000201001
 .
 38387
 0.14
chr13_30969133_30970071 0.09 HMGB1
 high mobility group box 1
 68782
 0.12
chr6_35744217_35744431 0.09 CLPSL2
 colipase-like 2
 68
 0.96
chr9_137437911_137438062 0.09 COL5A1
 collagen, type V, alpha 1
 95634
 0.07
chr12_66275134_66275285 0.08 RP11-366L20.2
 Uncharacterized protein
 149
 0.96
chr9_102130860_102131451 0.08 ENSG00000222337
 .
 84851
 0.09
chr4_164253766_164254020 0.08 NPY1R
 neuropeptide Y receptor Y1
 121
 0.97
chr18_60384328_60384953 0.08 PHLPP1
 PH domain and leucine rich repeat protein phosphatase 1
 1957
 0.36
chr4_174451067_174451315 0.08 HAND2
 heart and neural crest derivatives expressed 2
 189
 0.67
chr17_62038790_62038941 0.08 SCN4A
 sodium channel, voltage-gated, type IV, alpha subunit
 11413
 0.12
chr11_106889276_106889822 0.08 GUCY1A2
 guanylate cyclase 1, soluble, alpha 2
 299
 0.95
chr19_15218875_15219085 0.08 SYDE1
 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
 664
 0.57
chr7_100808865_100809016 0.08 VGF
 VGF nerve growth factor inducible
 66
 0.94
chr14_21852235_21852445 0.08 SUPT16H
 suppressor of Ty 16 homolog (S. cerevisiae)
 85
 0.52
chr19_36247080_36247289 0.08 HSPB6
 heat shock protein, alpha-crystallin-related, B6
 726
 0.32
chr17_65821514_65821703 0.08 BPTF
 bromodomain PHD finger transcription factor
 32
 0.97
chr9_33263612_33264186 0.08 BAG1
 BCL2-associated athanogene
 658
 0.51
chr11_68607958_68608409 0.08 CPT1A
 carnitine palmitoyltransferase 1A (liver)
 1031
 0.56
chr19_890673_890824 0.08 MED16
 mediator complex subunit 16
 383
 0.68
chr6_133134294_133134903 0.08 RPS12
 ribosomal protein S12
 982
 0.36
chr15_96952221_96952372 0.08 AC087477.1
 Uncharacterized protein
 47809
 0.13
chr20_23028362_23028696 0.08 THBD
 thrombomodulin
 1849
 0.28
chr7_2352113_2352318 0.08 SNX8
 sorting nexin 8
 1884
 0.35
chr20_48553017_48553241 0.08 RNF114
 ring finger protein 114
 181
 0.92
chr1_222885954_222886552 0.08 AIDA
 axin interactor, dorsalization associated
 273
 0.56
chr17_48450293_48450521 0.08 MRPL27
 mitochondrial ribosomal protein L27
 86
 0.61
chr8_143859070_143859321 0.08 LYNX1
 Ly6/neurotoxin 1
 31
 0.95
chr1_52831486_52831937 0.08 CC2D1B
 coiled-coil and C2 domain containing 1B
 140
 0.95
chr3_25825194_25825429 0.08 NGLY1
 N-glycanase 1
 269
 0.8
chr4_3529804_3529955 0.08 LRPAP1
 low density lipoprotein receptor-related protein associated protein 1
 4407
 0.19
chr12_72148572_72148842 0.08 RAB21
 RAB21, member RAS oncogene family
 53
 0.98
chr20_3661411_3661562 0.08 ADAM33
 ADAM metallopeptidase domain 33
 1264
 0.38
chr19_50379553_50379899 0.08 AKT1S1
 AKT1 substrate 1 (proline-rich)
 220
 0.74
chr8_42434678_42434829 0.08 SMIM19
 small integral membrane protein 19
 33182
 0.14
chr12_69007685_69008546 0.08 RAP1B
 RAP1B, member of RAS oncogene family
 3310
 0.27
chr17_6915641_6915886 0.08 RNASEK
 ribonuclease, RNase K
 27
 0.55
chr17_80339190_80339423 0.08 UTS2R
 urotensin 2 receptor
 7153
 0.1
chr6_34499951_34500102 0.08 PACSIN1
 protein kinase C and casein kinase substrate in neurons 1
 17362
 0.17
chr3_148709208_148709359 0.08 GYG1
 glycogenin 1
 16
 0.98
chr16_71879481_71879729 0.08 ATXN1L
 ataxin 1-like
 289
 0.47
chr2_133427812_133428020 0.08 LYPD1
 LY6/PLAUR domain containing 1
 138
 0.97
chr20_13202499_13202944 0.08 ISM1
 isthmin 1, angiogenesis inhibitor
 303
 0.91
chr16_54971124_54971492 0.08 IRX5
 iroquois homeobox 5
 5324
 0.35
chr1_1015177_1015464 0.08 RNF223
 ring finger protein 223
 5633
 0.1

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of TFEC_MITF_ARNTL_BHLHE41

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.1 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.2 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.0 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.0 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0 0.1 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.1 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.0 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.2 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0 0.0 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.0 GO:0014889 muscle atrophy(GO:0014889)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.0 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.0 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.0 GO:0071504 cellular response to heparin(GO:0071504)
0.0 0.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0 0.1 GO:0021903 rostrocaudal neural tube patterning(GO:0021903)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.0 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.0 GO:0090267 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.0 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.0 GO:0071816 protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.0 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.0 GO:0072081 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.0 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0009103 lipopolysaccharide biosynthetic process(GO:0009103)
0.0 0.0 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.1 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.0 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.1 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.0 0.0 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.0 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.0 GO:0048293 isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.0 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.0 GO:0000255 allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.2 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.0 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.0 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.0 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.1 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.3 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.2 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.0 0.1 GO:0005536 glucose binding(GO:0005536)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.0 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.0 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.0 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.0 GO:0043559 insulin binding(GO:0043559)
0.0 0.0 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.0 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.0 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.0 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway