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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for TGIF1

Z-value: 0.52

Motif logo

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Transcription factors associated with TGIF1

Gene Symbol Gene ID Gene Info
TGIF1
ENSG00000177426.16 TGFB induced factor homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr18_3462893_3463044TGIF175560.219731-0.627.5e-02Click!
chr18_3449680_3449975TGIF1530.9788360.581.0e-01Click!
chr18_3466935_3467086TGIF1115980.208355-0.561.2e-01Click!
chr18_3451670_3451935TGIF1800.9760290.531.4e-01Click!
chr18_3448296_3449430TGIF13660.8848200.531.4e-01Click!

Activity of the TGIF1 motif across conditions

Conditions sorted by the z-value of the TGIF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr22_17587813_17587964 0.35 CECR6
 cat eye syndrome chromosome region, candidate 6
 14255
 0.14
chr2_233925207_233925694 0.23 INPP5D
 inositol polyphosphate-5-phosphatase, 145kDa
 261
 0.92
chr2_143886988_143887259 0.22 ARHGAP15
 Rho GTPase activating protein 15
 240
 0.95
chr1_198608305_198608501 0.21 PTPRC
 protein tyrosine phosphatase, receptor type, C
 111
 0.98
chr15_93573821_93574103 0.21 CHD2
 chromodomain helicase DNA binding protein 2
 21866
 0.22
chr11_63273553_63274069 0.20 LGALS12
 lectin, galactoside-binding, soluble, 12
 24
 0.97
chr1_160681036_160681588 0.20 CD48
 CD48 molecule
 281
 0.89
chr17_4615541_4615774 0.19 ARRB2
 arrestin, beta 2
 1663
 0.18
chr1_47068584_47068735 0.19 MKNK1
 MAP kinase interacting serine/threonine kinase 1
 1227
 0.39
chr8_1953776_1953973 0.17 KBTBD11
 kelch repeat and BTB (POZ) domain containing 11
 31830
 0.2
chr10_73532392_73533248 0.17 C10orf54
 chromosome 10 open reading frame 54
 435
 0.83
chr17_56410837_56411117 0.16 MIR142
 microRNA 142
 1108
 0.32
chr7_157647247_157647398 0.16 AC011899.9
22
 0.98
chr6_133075391_133075542 0.16 RP1-55C23.7
1652
 0.26
chr15_58434934_58435085 0.16 ALDH1A2
 aldehyde dehydrogenase 1 family, member A2
 3985
 0.26
chr12_25206187_25206540 0.16 LRMP
 lymphoid-restricted membrane protein
 689
 0.71
chr11_2322790_2323148 0.15 C11orf21
 chromosome 11 open reading frame 21
 174
 0.62
chr17_8316817_8316968 0.15 NDEL1
 nudE neurodevelopment protein 1-like 1
 443
 0.73
chr15_94406450_94406737 0.15 ENSG00000222409
 .
 33663
 0.25
chr17_62709857_62710178 0.15 RP13-104F24.1
44704
 0.12
chr12_94545481_94545632 0.14 PLXNC1
 plexin C1
 3057
 0.29
chrX_47488390_47488605 0.14 CFP
 complement factor properdin
 797
 0.5
chr1_169677205_169677356 0.14 SELL
 selectin L
 3559
 0.24
chr6_11382170_11382539 0.14 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 178
 0.97
chr3_14274334_14274485 0.14 XPC
 xeroderma pigmentosum, complementation group C
 54126
 0.12
chr11_128589269_128589524 0.14 SENCR
 smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA
 23478
 0.17
chr12_93988367_93988869 0.14 SOCS2
 suppressor of cytokine signaling 2
 19784
 0.17
chr22_50523972_50524150 0.14 MLC1
 megalencephalic leukoencephalopathy with subcortical cysts 1
 207
 0.91
chr7_37714542_37714738 0.14 GPR141
 G protein-coupled receptor 141
 8760
 0.24
chr16_57926919_57927200 0.13 CNGB1
 cyclic nucleotide gated channel beta 1
 8218
 0.15
chr6_35568962_35570321 0.13 ENSG00000212579
 .
 49954
 0.1
chr10_94605706_94605908 0.13 EXOC6
 exocyst complex component 6
 2435
 0.4
chrX_71322682_71322935 0.13 RGAG4
 retrotransposon gag domain containing 4
 28870
 0.14
chr19_39826702_39826853 0.13 GMFG
 glia maturation factor, gamma
 48
 0.94
chr5_74964815_74965486 0.13 ENSG00000207333
 .
 40274
 0.14
chr19_1068869_1069054 0.13 HMHA1
 histocompatibility (minor) HA-1
 1464
 0.22
chr12_25205029_25205380 0.13 LRMP
 lymphoid-restricted membrane protein
 1
 0.98
chr11_71854965_71855116 0.13 FOLR3
 folate receptor 3 (gamma)
 8146
 0.09
chr7_130916444_130916595 0.13 MKLN1
 muskelin 1, intracellular mediator containing kelch motifs
 53302
 0.15
chr2_170684384_170685373 0.12 UBR3
 ubiquitin protein ligase E3 component n-recognin 3 (putative)
 860
 0.53
chr17_76259158_76259368 0.12 TMEM235
 transmembrane protein 235
 31141
 0.11
chr7_141646471_141646694 0.12 CLEC5A
 C-type lectin domain family 5, member A
 151
 0.94
chr9_75204897_75205048 0.12 TMC1
 transmembrane channel-like 1
 24644
 0.24
chr15_99499935_99500086 0.12 IGF1R
 insulin-like growth factor 1 receptor
 32181
 0.16
chr5_137449279_137449579 0.12 ENSG00000238605
 .
 1564
 0.23
chr11_44588275_44588433 0.12 CD82
 CD82 molecule
 1081
 0.58
chr2_158296405_158296556 0.12 CYTIP
 cytohesin 1 interacting protein
 554
 0.73
chr5_53886312_53886463 0.12 SNX18
 sorting nexin 18
 72794
 0.12
chr22_37639373_37639682 0.12 RAC2
 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
 761
 0.58
chr1_236028992_236029750 0.12 LYST
 lysosomal trafficking regulator
 849
 0.53
chr19_13211050_13211262 0.12 LYL1
 lymphoblastic leukemia derived sequence 1
 2525
 0.16
chr3_172240144_172241280 0.12 TNFSF10
 tumor necrosis factor (ligand) superfamily, member 10
 553
 0.83
chr8_134094409_134094685 0.12 SLA
 Src-like-adaptor
 20174
 0.21
chr4_37866428_37866579 0.12 TBC1D1
 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
 26205
 0.2
chr6_140241181_140241350 0.12 ENSG00000252107
 .
 238566
 0.02
chr1_40530106_40530257 0.12 PPT1
 palmitoyl-protein thioesterase 1
 17812
 0.17
chr13_108918883_108919034 0.12 TNFSF13B
 tumor necrosis factor (ligand) superfamily, member 13b
 3019
 0.28
chr3_16883275_16883542 0.11 PLCL2
 phospholipase C-like 2
 43044
 0.19
chr1_192128557_192128890 0.11 RGS18
 regulator of G-protein signaling 18
 1136
 0.67
chr17_43486558_43486834 0.11 ARHGAP27
 Rho GTPase activating protein 27
 1056
 0.39
chr6_6687519_6687926 0.11 LY86-AS1
 LY86 antisense RNA 1
 64718
 0.14
chr2_113599211_113599362 0.11 ENSG00000221541
 .
 2602
 0.24
chr5_81074467_81075538 0.11 SSBP2
 single-stranded DNA binding protein 2
 27930
 0.25
chr9_7653385_7653536 0.11 TMEM261
 transmembrane protein 261
 146607
 0.05
chr1_40804569_40804738 0.11 SMAP2
 small ArfGAP2
 5869
 0.18
chr15_58432158_58432309 0.11 ALDH1A2
 aldehyde dehydrogenase 1 family, member A2
 1209
 0.44
chr6_160374740_160374891 0.11 IGF2R
 insulin-like growth factor 2 receptor
 15316
 0.2
chr21_36398861_36399526 0.11 RUNX1
 runt-related transcription factor 1
 22269
 0.28
chr3_67452818_67452969 0.11 SUCLG2
 succinate-CoA ligase, GDP-forming, beta subunit
 125753
 0.06
chr12_105064873_105065024 0.11 ENSG00000264295
 .
 79537
 0.1
chr9_134131290_134131650 0.11 FAM78A
 family with sequence similarity 78, member A
 14410
 0.16
chr19_2083107_2083981 0.11 MOB3A
 MOB kinase activator 3A
 1847
 0.21
chr15_93383088_93383239 0.11 ENSG00000264123
 .
 16570
 0.15
chr1_207670300_207670451 0.11 CR1
 complement component (3b/4b) receptor 1 (Knops blood group)
 689
 0.7
chr15_31558250_31558401 0.11 KLF13
 Kruppel-like factor 13
 60733
 0.14
chr13_108921982_108923111 0.11 TNFSF13B
 tumor necrosis factor (ligand) superfamily, member 13b
 302
 0.91
chr10_129846734_129847253 0.11 PTPRE
 protein tyrosine phosphatase, receptor type, E
 1159
 0.62
chr1_192485875_192486153 0.11 ENSG00000221145
 .
 25664
 0.2
chr5_139594597_139594748 0.11 CTB-131B5.2
14924
 0.14
chr3_183272411_183272703 0.11 KLHL6
 kelch-like family member 6
 920
 0.55
chr14_65511670_65511821 0.11 ENSG00000266531
 .
 339
 0.84
chrX_9309324_9309596 0.11 TBL1X
 transducin (beta)-like 1X-linked
 121875
 0.06
chr2_68917176_68917327 0.10 ARHGAP25
 Rho GTPase activating protein 25
 20383
 0.22
chr10_106079197_106079348 0.10 RP11-127L20.5
7373
 0.13
chr1_149754304_149754780 0.10 FCGR1A
 Fc fragment of IgG, high affinity Ia, receptor (CD64)
 296
 0.78
chr14_51394671_51394858 0.10 RP11-218E20.5
15820
 0.16
chr7_134836109_134836260 0.10 AC083862.1
 Uncharacterized protein
 3268
 0.17
chr13_105792322_105792542 0.10 DAOA
 D-amino acid oxidase activator
 326160
 0.01
chr1_9690042_9690512 0.10 PIK3CD
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
 21513
 0.15
chr4_84406493_84406893 0.10 FAM175A
 family with sequence similarity 175, member A
 15
 0.98
chr2_60561577_60561728 0.10 ENSG00000200807
 .
 50088
 0.15
chr9_92111480_92111784 0.10 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 715
 0.59
chr2_87834277_87834469 0.10 RP11-1399P15.1
56820
 0.15
chr16_2390604_2390763 0.10 ABCA3
 ATP-binding cassette, sub-family A (ABC1), member 3
 53
 0.95
chr1_12235343_12235565 0.10 TNFRSF1B
 tumor necrosis factor receptor superfamily, member 1B
 8394
 0.16
chr1_150976139_150976311 0.10 FAM63A
 family with sequence similarity 63, member A
 2736
 0.12
chr6_133068019_133068170 0.10 RP1-55C23.7
5720
 0.13
chr6_7255590_7255764 0.10 RP11-69L16.4
20587
 0.18
chr6_2222017_2222664 0.10 GMDS
 GDP-mannose 4,6-dehydratase
 23586
 0.28
chr4_15255941_15256092 0.10 RP11-665G4.1
26432
 0.23
chrX_128914480_128914899 0.10 SASH3
 SAM and SH3 domain containing 3
 729
 0.68
chr20_52239578_52240391 0.10 ZNF217
 zinc finger protein 217
 14553
 0.2
chr8_126517925_126518109 0.10 ENSG00000266452
 .
 61210
 0.13
chr10_35776313_35776464 0.10 GJD4
 gap junction protein, delta 4, 40.1kDa
 117950
 0.05
chr9_126959092_126959243 0.10 NEK6
 NIMA-related kinase 6
 60718
 0.11
chr17_4617667_4617818 0.10 ARRB2
 arrestin, beta 2
 1142
 0.27
chr9_101899616_101899767 0.10 ENSG00000252942
 .
 8557
 0.19
chr4_7061545_7061696 0.10 TADA2B
 transcriptional adaptor 2B
 6540
 0.13
chr17_4618141_4618477 0.10 ARRB2
 arrestin, beta 2
 575
 0.53
chr11_10622266_10622417 0.10 MRVI1-AS1
 MRVI1 antisense RNA 1
 7597
 0.18
chr6_167142579_167142730 0.10 RPS6KA2
 ribosomal protein S6 kinase, 90kDa, polypeptide 2
 28745
 0.23
chr1_36912199_36912350 0.10 OSCP1
 organic solute carrier partner 1
 3606
 0.17
chr7_36231064_36231268 0.10 EEPD1
 endonuclease/exonuclease/phosphatase family domain containing 1
 38289
 0.15
chr1_54871768_54871919 0.10 SSBP3
 single stranded DNA binding protein 3
 53
 0.98
chr2_238889883_238890034 0.10 UBE2F
 ubiquitin-conjugating enzyme E2F (putative)
 8221
 0.21
chr11_65407442_65407916 0.10 SIPA1
 signal-induced proliferation-associated 1
 87
 0.92
chr8_38663476_38663627 0.10 TACC1
 transforming, acidic coiled-coil containing protein 1
 583
 0.73
chr19_1856469_1856846 0.10 CTB-31O20.8
3592
 0.1
chr10_28822829_28823308 0.10 WAC
 WW domain containing adaptor with coiled-coil
 16
 0.97
chr4_40199803_40200006 0.10 RHOH
 ras homolog family member H
 1377
 0.47
chr11_1909549_1909755 0.10 C11orf89
 chromosome 11 open reading frame 89
 2432
 0.16
chr10_30831582_30831733 0.10 ENSG00000239744
 .
 13176
 0.24
chr17_38374834_38374985 0.10 WIPF2
 WAS/WASL interacting protein family, member 2
 647
 0.63
chr6_108145054_108145346 0.09 SCML4
 sex comb on midleg-like 4 (Drosophila)
 316
 0.93
chr2_121096009_121096160 0.09 INHBB
 inhibin, beta B
 7635
 0.26
chr1_26453661_26453812 0.09 PDIK1L
 PDLIM1 interacting kinase 1 like
 15396
 0.1
chr14_68283462_68283835 0.09 ZFYVE26
 zinc finger, FYVE domain containing 26
 342
 0.86
chr3_186631546_186631697 0.09 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 16653
 0.16
chr7_102072016_102072236 0.09 ORAI2
 ORAI calcium release-activated calcium modulator 2
 1427
 0.22
chr6_11519933_11520084 0.09 ENSG00000202313
 .
 16104
 0.22
chr16_81037806_81038351 0.09 CENPN
 centromere protein N
 2025
 0.2
chr19_14896102_14896264 0.09 EMR2
 egf-like module containing, mucin-like, hormone receptor-like 2
 6830
 0.15
chr19_49139505_49139656 0.09 DBP
 D site of albumin promoter (albumin D-box) binding protein
 1040
 0.28
chr20_58630648_58631293 0.09 C20orf197
 chromosome 20 open reading frame 197
 10
 0.98
chr1_90278526_90278677 0.09 LRRC8D
 leucine rich repeat containing 8 family, member D
 7972
 0.21
chr19_36398415_36398818 0.09 TYROBP
 TYRO protein tyrosine kinase binding protein
 533
 0.58
chr1_151170363_151170514 0.09 PIP5K1A
 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
 13
 0.95
chr11_129697989_129698558 0.09 TMEM45B
 transmembrane protein 45B
 12559
 0.26
chr12_51722623_51722774 0.09 BIN2
 bridging integrator 2
 4246
 0.18
chr6_106233724_106233875 0.09 ENSG00000200198
 .
 118449
 0.06
chr10_129333006_129333157 0.09 NPS
 neuropeptide S
 14532
 0.3
chr9_101899309_101899497 0.09 ENSG00000252942
 .
 8845
 0.19
chr11_77762153_77762304 0.09 KCTD14
 potassium channel tetramerization domain containing 14
 4991
 0.13
chr3_169672312_169672463 0.09 RP11-379K17.4
11515
 0.14
chr4_185729074_185729225 0.09 ACSL1
 acyl-CoA synthetase long-chain family member 1
 456
 0.81
chr1_120935748_120935992 0.09 FCGR1B
 Fc fragment of IgG, high affinity Ib, receptor (CD64)
 24
 0.97
chr22_17082347_17082639 0.09 ENSG00000221084
 .
 2799
 0.23
chr19_13960913_13961064 0.09 ENSG00000207980
 .
 13515
 0.07
chr6_29933308_29933483 0.09 HLA-A
 major histocompatibility complex, class I, A
 23069
 0.14
chr8_21754477_21754628 0.09 DOK2
 docking protein 2, 56kDa
 16622
 0.18
chr17_29646389_29646953 0.09 CTD-2370N5.3
822
 0.44
chr3_35722538_35722689 0.09 ARPP21
 cAMP-regulated phosphoprotein, 21kDa
 121
 0.97
chr6_166667247_166667511 0.09 ENSG00000201292
 .
 44488
 0.14
chr3_101405604_101405866 0.09 RPL24
 ribosomal protein L24
 109
 0.94
chr14_95927410_95927561 0.09 SYNE3
 spectrin repeat containing, nuclear envelope family member 3
 4959
 0.23
chr1_89591826_89592005 0.09 GBP2
 guanylate binding protein 2, interferon-inducible
 118
 0.97
chr13_41884953_41885353 0.09 NAA16
 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
 188
 0.95
chrX_48793999_48794379 0.09 PIM2
 pim-2 oncogene
 17888
 0.08
chr20_58676178_58676329 0.09 C20orf197
 chromosome 20 open reading frame 197
 45273
 0.17
chr16_23864221_23864482 0.09 PRKCB
 protein kinase C, beta
 15807
 0.23
chr5_142985423_142985638 0.09 CTB-57H20.1
337
 0.92
chr6_119634479_119634630 0.09 ENSG00000200732
 .
 13892
 0.25
chr8_142219697_142219848 0.09 DENND3
 DENN/MADD domain containing 3
 17342
 0.15
chr2_68477764_68478263 0.09 PPP3R1
 protein phosphatase 3, regulatory subunit B, alpha
 267
 0.87
chr11_10626007_10626277 0.09 MRVI1-AS1
 MRVI1 antisense RNA 1
 11398
 0.17
chr11_2324787_2325062 0.09 TSPAN32
 tetraspanin 32
 826
 0.45
chr12_108909076_108909295 0.09 FICD
 FIC domain containing
 92
 0.96
chr8_53851786_53851937 0.09 NPBWR1
 neuropeptides B/W receptor 1
 870
 0.7
chr19_54713150_54713301 0.09 RPS9
 ribosomal protein S9
 8197
 0.07
chr6_42013197_42013548 0.09 CCND3
 cyclin D3
 3052
 0.21
chr12_117073537_117073765 0.08 MAP1LC3B2
 microtubule-associated protein 1 light chain 3 beta 2
 59995
 0.13
chr1_36621953_36622250 0.08 MAP7D1
 MAP7 domain containing 1
 298
 0.87
chr17_29640754_29641122 0.08 EVI2B
 ecotropic viral integration site 2B
 164
 0.93
chr5_10445338_10445751 0.08 ROPN1L
 rhophilin associated tail protein 1-like
 3556
 0.18
chr8_48515171_48515322 0.08 SPIDR
 scaffolding protein involved in DNA repair
 56980
 0.12
chr8_126446403_126446861 0.08 TRIB1
 tribbles pseudokinase 1
 844
 0.67
chr12_4312868_4313019 0.08 CCND2
 cyclin D2
 69995
 0.1
chr4_129732983_129734245 0.08 JADE1
 jade family PHD finger 1
 615
 0.83
chr5_55884070_55884221 0.08 AC022431.2
 Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.
 17914
 0.22
chr10_134385473_134385624 0.08 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 33905
 0.18
chr7_37389906_37390077 0.08 ENSG00000222869
 .
 756
 0.67
chr17_73682901_73683052 0.08 RP11-474I11.7
2097
 0.17
chr13_50202297_50202533 0.08 ARL11
 ADP-ribosylation factor-like 11
 20
 0.98
chr11_2468512_2468676 0.08 KCNQ1
 potassium voltage-gated channel, KQT-like subfamily, member 1
 2373
 0.23
chr14_73932367_73932610 0.08 ENSG00000251393
 .
 3359
 0.19
chr8_95956511_95956662 0.08 TP53INP1
 tumor protein p53 inducible nuclear protein 1
 3385
 0.17
chr2_54657230_54657381 0.08 SPTBN1
 spectrin, beta, non-erythrocytic 1
 26117
 0.21
chr1_116293768_116293919 0.08 CASQ2
 calsequestrin 2 (cardiac muscle)
 17492
 0.24
chr9_132830835_132830986 0.08 GPR107
 G protein-coupled receptor 107
 14925
 0.18
chr4_6918537_6918793 0.08 TBC1D14
 TBC1 domain family, member 14
 6690
 0.19
chr11_77167116_77167267 0.08 DKFZP434E1119
17225
 0.19
chr15_43531850_43532099 0.08 ENSG00000202211
 .
 7904
 0.13
chr17_8076861_8077643 0.08 ENSG00000200463
 .
 347
 0.7
chr20_48962765_48962916 0.08 ENSG00000244376
 .
 83180
 0.09
chr12_54693479_54693635 0.08 NFE2
 nuclear factor, erythroid 2
 1242
 0.21
chr5_10635367_10635573 0.08 ANKRD33B-AS1
 ANKRD33B antisense RNA 1
 7133
 0.25
chr5_163147994_163148145 0.08 ENSG00000251998
 .
 75102
 0.12
chr16_85793045_85793254 0.08 C16orf74
 chromosome 16 open reading frame 74
 8414
 0.11
chr12_15113710_15114247 0.08 ARHGDIB
 Rho GDP dissociation inhibitor (GDI) beta
 222
 0.92
chr19_50269466_50269673 0.08 AP2A1
 adaptor-related protein complex 2, alpha 1 subunit
 656
 0.43

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of TGIF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.2 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0002540 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.2 GO:0010310 regulation of hydrogen peroxide metabolic process(GO:0010310)
0.0 0.0 GO:0034113 heterotypic cell-cell adhesion(GO:0034113) regulation of heterotypic cell-cell adhesion(GO:0034114)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.0 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0090267 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.0 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.0 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.3 GO:0045576 mast cell activation(GO:0045576)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.0 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0006265 DNA topological change(GO:0006265)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.1 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.0 GO:0014805 smooth muscle adaptation(GO:0014805)
0.0 0.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0006388 RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.0 GO:1903312 negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0 0.0 GO:0006007 glucose catabolic process(GO:0006007)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.0 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0032747 interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0 0.1 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.1 GO:0002467 germinal center formation(GO:0002467)
0.0 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.0 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.0 GO:0008215 spermine metabolic process(GO:0008215)
0.0 0.1 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 0.0 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0 0.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.0 GO:0001865 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.0 GO:0002448 mast cell mediated immunity(GO:0002448)
0.0 0.0 GO:1903960 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.1 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.0 GO:0032717 negative regulation of interleukin-8 production(GO:0032717)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.0 GO:0031297 replication fork processing(GO:0031297)
0.0 0.0 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.0 GO:0032490 detection of molecule of bacterial origin(GO:0032490)
0.0 0.0 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.1 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.0 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.0 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.1 0.3 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.0 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.0 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.1 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0005536 glucose binding(GO:0005536)
0.0 0.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.0 0.0 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.0 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.0 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.0 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.0 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.0 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0001848 complement binding(GO:0001848)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.0 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi