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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TGIF1

Z-value: 0.52

Motif logo

Transcription factors associated with TGIF1

Gene Symbol	Gene ID	Gene Info
TGIF1 Ensembl NCBI GeneCards UniProt	ENSG00000177426.16	TGIF1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
TGIF1	chr18_3462893_3463044	7556	0.219731	-0.62	7.5e-02	Click!
TGIF1	chr18_3449680_3449975	53	0.978836	0.58	1.0e-01	Click!
TGIF1	chr18_3466935_3467086	11598	0.208355	-0.56	1.2e-01	Click!
TGIF1	chr18_3451670_3451935	80	0.976029	0.53	1.4e-01	Click!
TGIF1	chr18_3448296_3449430	366	0.884820	0.53	1.4e-01	Click!

Activity of the TGIF1 motif across conditions

Conditions sorted by the z-value of the TGIF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr22_17587813_17587964	0.35	CECR6	cat eye syndrome chromosome region, candidate 6	14255	0.14
chr2_233925207_233925694	0.23	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	261	0.92
chr2_143886988_143887259	0.22	ARHGAP15	Rho GTPase activating protein 15	240	0.95
chr1_198608305_198608501	0.21	PTPRC	protein tyrosine phosphatase, receptor type, C	111	0.98
chr15_93573821_93574103	0.21	CHD2	chromodomain helicase DNA binding protein 2	21866	0.22
chr11_63273553_63274069	0.20	LGALS12	lectin, galactoside-binding, soluble, 12	24	0.97
chr1_160681036_160681588	0.20	CD48	CD48 molecule	281	0.89
chr17_4615541_4615774	0.19	ARRB2	arrestin, beta 2	1663	0.18
chr1_47068584_47068735	0.19	MKNK1	MAP kinase interacting serine/threonine kinase 1	1227	0.39
chr8_1953776_1953973	0.17	KBTBD11	kelch repeat and BTB (POZ) domain containing 11	31830	0.2
chr10_73532392_73533248	0.17	C10orf54	chromosome 10 open reading frame 54	435	0.83
chr17_56410837_56411117	0.16	MIR142	microRNA 142	1108	0.32
chr7_157647247_157647398	0.16	AC011899.9		22	0.98
chr6_133075391_133075542	0.16	RP1-55C23.7		1652	0.26
chr15_58434934_58435085	0.16	ALDH1A2	aldehyde dehydrogenase 1 family, member A2	3985	0.26
chr12_25206187_25206540	0.16	LRMP	lymphoid-restricted membrane protein	689	0.71
chr11_2322790_2323148	0.15	C11orf21	chromosome 11 open reading frame 21	174	0.62
chr17_8316817_8316968	0.15	NDEL1	nudE neurodevelopment protein 1-like 1	443	0.73
chr15_94406450_94406737	0.15	ENSG00000222409	.	33663	0.25
chr17_62709857_62710178	0.15	RP13-104F24.1		44704	0.12
chr12_94545481_94545632	0.14	PLXNC1	plexin C1	3057	0.29
chrX_47488390_47488605	0.14	CFP	complement factor properdin	797	0.5
chr1_169677205_169677356	0.14	SELL	selectin L	3559	0.24
chr6_11382170_11382539	0.14	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	178	0.97
chr3_14274334_14274485	0.14	XPC	xeroderma pigmentosum, complementation group C	54126	0.12
chr11_128589269_128589524	0.14	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	23478	0.17
chr12_93988367_93988869	0.14	SOCS2	suppressor of cytokine signaling 2	19784	0.17
chr22_50523972_50524150	0.14	MLC1	megalencephalic leukoencephalopathy with subcortical cysts 1	207	0.91
chr7_37714542_37714738	0.14	GPR141	G protein-coupled receptor 141	8760	0.24
chr16_57926919_57927200	0.13	CNGB1	cyclic nucleotide gated channel beta 1	8218	0.15
chr6_35568962_35570321	0.13	ENSG00000212579	.	49954	0.1
chr10_94605706_94605908	0.13	EXOC6	exocyst complex component 6	2435	0.4
chrX_71322682_71322935	0.13	RGAG4	retrotransposon gag domain containing 4	28870	0.14
chr19_39826702_39826853	0.13	GMFG	glia maturation factor, gamma	48	0.94
chr5_74964815_74965486	0.13	ENSG00000207333	.	40274	0.14
chr19_1068869_1069054	0.13	HMHA1	histocompatibility (minor) HA-1	1464	0.22
chr12_25205029_25205380	0.13	LRMP	lymphoid-restricted membrane protein	1	0.98
chr11_71854965_71855116	0.13	FOLR3	folate receptor 3 (gamma)	8146	0.09
chr7_130916444_130916595	0.13	MKLN1	muskelin 1, intracellular mediator containing kelch motifs	53302	0.15
chr2_170684384_170685373	0.12	UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	860	0.53
chr17_76259158_76259368	0.12	TMEM235	transmembrane protein 235	31141	0.11
chr7_141646471_141646694	0.12	CLEC5A	C-type lectin domain family 5, member A	151	0.94
chr9_75204897_75205048	0.12	TMC1	transmembrane channel-like 1	24644	0.24
chr15_99499935_99500086	0.12	IGF1R	insulin-like growth factor 1 receptor	32181	0.16
chr5_137449279_137449579	0.12	ENSG00000238605	.	1564	0.23
chr11_44588275_44588433	0.12	CD82	CD82 molecule	1081	0.58
chr2_158296405_158296556	0.12	CYTIP	cytohesin 1 interacting protein	554	0.73
chr5_53886312_53886463	0.12	SNX18	sorting nexin 18	72794	0.12
chr22_37639373_37639682	0.12	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	761	0.58
chr1_236028992_236029750	0.12	LYST	lysosomal trafficking regulator	849	0.53
chr19_13211050_13211262	0.12	LYL1	lymphoblastic leukemia derived sequence 1	2525	0.16
chr3_172240144_172241280	0.12	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	553	0.83
chr8_134094409_134094685	0.12	SLA	Src-like-adaptor	20174	0.21
chr4_37866428_37866579	0.12	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	26205	0.2
chr6_140241181_140241350	0.12	ENSG00000252107	.	238566	0.02
chr1_40530106_40530257	0.12	PPT1	palmitoyl-protein thioesterase 1	17812	0.17
chr13_108918883_108919034	0.12	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	3019	0.28
chr3_16883275_16883542	0.11	PLCL2	phospholipase C-like 2	43044	0.19
chr1_192128557_192128890	0.11	RGS18	regulator of G-protein signaling 18	1136	0.67
chr17_43486558_43486834	0.11	ARHGAP27	Rho GTPase activating protein 27	1056	0.39
chr6_6687519_6687926	0.11	LY86-AS1	LY86 antisense RNA 1	64718	0.14
chr2_113599211_113599362	0.11	ENSG00000221541	.	2602	0.24
chr5_81074467_81075538	0.11	SSBP2	single-stranded DNA binding protein 2	27930	0.25
chr9_7653385_7653536	0.11	TMEM261	transmembrane protein 261	146607	0.05
chr1_40804569_40804738	0.11	SMAP2	small ArfGAP2	5869	0.18
chr15_58432158_58432309	0.11	ALDH1A2	aldehyde dehydrogenase 1 family, member A2	1209	0.44
chr6_160374740_160374891	0.11	IGF2R	insulin-like growth factor 2 receptor	15316	0.2
chr21_36398861_36399526	0.11	RUNX1	runt-related transcription factor 1	22269	0.28
chr3_67452818_67452969	0.11	SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	125753	0.06
chr12_105064873_105065024	0.11	ENSG00000264295	.	79537	0.1
chr9_134131290_134131650	0.11	FAM78A	family with sequence similarity 78, member A	14410	0.16
chr19_2083107_2083981	0.11	MOB3A	MOB kinase activator 3A	1847	0.21
chr15_93383088_93383239	0.11	ENSG00000264123	.	16570	0.15
chr1_207670300_207670451	0.11	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	689	0.7
chr15_31558250_31558401	0.11	KLF13	Kruppel-like factor 13	60733	0.14
chr13_108921982_108923111	0.11	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	302	0.91
chr10_129846734_129847253	0.11	PTPRE	protein tyrosine phosphatase, receptor type, E	1159	0.62
chr1_192485875_192486153	0.11	ENSG00000221145	.	25664	0.2
chr5_139594597_139594748	0.11	CTB-131B5.2		14924	0.14
chr3_183272411_183272703	0.11	KLHL6	kelch-like family member 6	920	0.55
chr14_65511670_65511821	0.11	ENSG00000266531	.	339	0.84
chrX_9309324_9309596	0.11	TBL1X	transducin (beta)-like 1X-linked	121875	0.06
chr2_68917176_68917327	0.10	ARHGAP25	Rho GTPase activating protein 25	20383	0.22
chr10_106079197_106079348	0.10	RP11-127L20.5		7373	0.13
chr1_149754304_149754780	0.10	FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)	296	0.78
chr14_51394671_51394858	0.10	RP11-218E20.5		15820	0.16
chr7_134836109_134836260	0.10	AC083862.1	Uncharacterized protein	3268	0.17
chr13_105792322_105792542	0.10	DAOA	D-amino acid oxidase activator	326160	0.01
chr1_9690042_9690512	0.10	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	21513	0.15
chr4_84406493_84406893	0.10	FAM175A	family with sequence similarity 175, member A	15	0.98
chr2_60561577_60561728	0.10	ENSG00000200807	.	50088	0.15
chr9_92111480_92111784	0.10	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	715	0.59
chr2_87834277_87834469	0.10	RP11-1399P15.1		56820	0.15
chr16_2390604_2390763	0.10	ABCA3	ATP-binding cassette, sub-family A (ABC1), member 3	53	0.95
chr1_12235343_12235565	0.10	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	8394	0.16
chr1_150976139_150976311	0.10	FAM63A	family with sequence similarity 63, member A	2736	0.12
chr6_133068019_133068170	0.10	RP1-55C23.7		5720	0.13
chr6_7255590_7255764	0.10	RP11-69L16.4		20587	0.18
chr6_2222017_2222664	0.10	GMDS	GDP-mannose 4,6-dehydratase	23586	0.28
chr4_15255941_15256092	0.10	RP11-665G4.1		26432	0.23
chrX_128914480_128914899	0.10	SASH3	SAM and SH3 domain containing 3	729	0.68
chr20_52239578_52240391	0.10	ZNF217	zinc finger protein 217	14553	0.2
chr8_126517925_126518109	0.10	ENSG00000266452	.	61210	0.13
chr10_35776313_35776464	0.10	GJD4	gap junction protein, delta 4, 40.1kDa	117950	0.05
chr9_126959092_126959243	0.10	NEK6	NIMA-related kinase 6	60718	0.11
chr17_4617667_4617818	0.10	ARRB2	arrestin, beta 2	1142	0.27
chr9_101899616_101899767	0.10	ENSG00000252942	.	8557	0.19
chr4_7061545_7061696	0.10	TADA2B	transcriptional adaptor 2B	6540	0.13
chr17_4618141_4618477	0.10	ARRB2	arrestin, beta 2	575	0.53
chr11_10622266_10622417	0.10	MRVI1-AS1	MRVI1 antisense RNA 1	7597	0.18
chr6_167142579_167142730	0.10	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	28745	0.23
chr1_36912199_36912350	0.10	OSCP1	organic solute carrier partner 1	3606	0.17
chr7_36231064_36231268	0.10	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	38289	0.15
chr1_54871768_54871919	0.10	SSBP3	single stranded DNA binding protein 3	53	0.98
chr2_238889883_238890034	0.10	UBE2F	ubiquitin-conjugating enzyme E2F (putative)	8221	0.21
chr11_65407442_65407916	0.10	SIPA1	signal-induced proliferation-associated 1	87	0.92
chr8_38663476_38663627	0.10	TACC1	transforming, acidic coiled-coil containing protein 1	583	0.73
chr19_1856469_1856846	0.10	CTB-31O20.8		3592	0.1
chr10_28822829_28823308	0.10	WAC	WW domain containing adaptor with coiled-coil	16	0.97
chr4_40199803_40200006	0.10	RHOH	ras homolog family member H	1377	0.47
chr11_1909549_1909755	0.10	C11orf89	chromosome 11 open reading frame 89	2432	0.16
chr10_30831582_30831733	0.10	ENSG00000239744	.	13176	0.24
chr17_38374834_38374985	0.10	WIPF2	WAS/WASL interacting protein family, member 2	647	0.63
chr6_108145054_108145346	0.09	SCML4	sex comb on midleg-like 4 (Drosophila)	316	0.93
chr2_121096009_121096160	0.09	INHBB	inhibin, beta B	7635	0.26
chr1_26453661_26453812	0.09	PDIK1L	PDLIM1 interacting kinase 1 like	15396	0.1
chr14_68283462_68283835	0.09	ZFYVE26	zinc finger, FYVE domain containing 26	342	0.86
chr3_186631546_186631697	0.09	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	16653	0.16
chr7_102072016_102072236	0.09	ORAI2	ORAI calcium release-activated calcium modulator 2	1427	0.22
chr6_11519933_11520084	0.09	ENSG00000202313	.	16104	0.22
chr16_81037806_81038351	0.09	CENPN	centromere protein N	2025	0.2
chr19_14896102_14896264	0.09	EMR2	egf-like module containing, mucin-like, hormone receptor-like 2	6830	0.15
chr19_49139505_49139656	0.09	DBP	D site of albumin promoter (albumin D-box) binding protein	1040	0.28
chr20_58630648_58631293	0.09	C20orf197	chromosome 20 open reading frame 197	10	0.98
chr1_90278526_90278677	0.09	LRRC8D	leucine rich repeat containing 8 family, member D	7972	0.21
chr19_36398415_36398818	0.09	TYROBP	TYRO protein tyrosine kinase binding protein	533	0.58
chr1_151170363_151170514	0.09	PIP5K1A	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	13	0.95
chr11_129697989_129698558	0.09	TMEM45B	transmembrane protein 45B	12559	0.26
chr12_51722623_51722774	0.09	BIN2	bridging integrator 2	4246	0.18
chr6_106233724_106233875	0.09	ENSG00000200198	.	118449	0.06
chr10_129333006_129333157	0.09	NPS	neuropeptide S	14532	0.3
chr9_101899309_101899497	0.09	ENSG00000252942	.	8845	0.19
chr11_77762153_77762304	0.09	KCTD14	potassium channel tetramerization domain containing 14	4991	0.13
chr3_169672312_169672463	0.09	RP11-379K17.4		11515	0.14
chr4_185729074_185729225	0.09	ACSL1	acyl-CoA synthetase long-chain family member 1	456	0.81
chr1_120935748_120935992	0.09	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	24	0.97
chr22_17082347_17082639	0.09	ENSG00000221084	.	2799	0.23
chr19_13960913_13961064	0.09	ENSG00000207980	.	13515	0.07
chr6_29933308_29933483	0.09	HLA-A	major histocompatibility complex, class I, A	23069	0.14
chr8_21754477_21754628	0.09	DOK2	docking protein 2, 56kDa	16622	0.18
chr17_29646389_29646953	0.09	CTD-2370N5.3		822	0.44
chr3_35722538_35722689	0.09	ARPP21	cAMP-regulated phosphoprotein, 21kDa	121	0.97
chr6_166667247_166667511	0.09	ENSG00000201292	.	44488	0.14
chr3_101405604_101405866	0.09	RPL24	ribosomal protein L24	109	0.94
chr14_95927410_95927561	0.09	SYNE3	spectrin repeat containing, nuclear envelope family member 3	4959	0.23
chr1_89591826_89592005	0.09	GBP2	guanylate binding protein 2, interferon-inducible	118	0.97
chr13_41884953_41885353	0.09	NAA16	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	188	0.95
chrX_48793999_48794379	0.09	PIM2	pim-2 oncogene	17888	0.08
chr20_58676178_58676329	0.09	C20orf197	chromosome 20 open reading frame 197	45273	0.17
chr16_23864221_23864482	0.09	PRKCB	protein kinase C, beta	15807	0.23
chr5_142985423_142985638	0.09	CTB-57H20.1		337	0.92
chr6_119634479_119634630	0.09	ENSG00000200732	.	13892	0.25
chr8_142219697_142219848	0.09	DENND3	DENN/MADD domain containing 3	17342	0.15
chr2_68477764_68478263	0.09	PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	267	0.87
chr11_10626007_10626277	0.09	MRVI1-AS1	MRVI1 antisense RNA 1	11398	0.17
chr11_2324787_2325062	0.09	TSPAN32	tetraspanin 32	826	0.45
chr12_108909076_108909295	0.09	FICD	FIC domain containing	92	0.96
chr8_53851786_53851937	0.09	NPBWR1	neuropeptides B/W receptor 1	870	0.7
chr19_54713150_54713301	0.09	RPS9	ribosomal protein S9	8197	0.07
chr6_42013197_42013548	0.09	CCND3	cyclin D3	3052	0.21
chr12_117073537_117073765	0.08	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	59995	0.13
chr1_36621953_36622250	0.08	MAP7D1	MAP7 domain containing 1	298	0.87
chr17_29640754_29641122	0.08	EVI2B	ecotropic viral integration site 2B	164	0.93
chr5_10445338_10445751	0.08	ROPN1L	rhophilin associated tail protein 1-like	3556	0.18
chr8_48515171_48515322	0.08	SPIDR	scaffolding protein involved in DNA repair	56980	0.12
chr8_126446403_126446861	0.08	TRIB1	tribbles pseudokinase 1	844	0.67
chr12_4312868_4313019	0.08	CCND2	cyclin D2	69995	0.1
chr4_129732983_129734245	0.08	JADE1	jade family PHD finger 1	615	0.83
chr5_55884070_55884221	0.08	AC022431.2	Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.	17914	0.22
chr10_134385473_134385624	0.08	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	33905	0.18
chr7_37389906_37390077	0.08	ENSG00000222869	.	756	0.67
chr17_73682901_73683052	0.08	RP11-474I11.7		2097	0.17
chr13_50202297_50202533	0.08	ARL11	ADP-ribosylation factor-like 11	20	0.98
chr11_2468512_2468676	0.08	KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	2373	0.23
chr14_73932367_73932610	0.08	ENSG00000251393	.	3359	0.19
chr8_95956511_95956662	0.08	TP53INP1	tumor protein p53 inducible nuclear protein 1	3385	0.17
chr2_54657230_54657381	0.08	SPTBN1	spectrin, beta, non-erythrocytic 1	26117	0.21
chr1_116293768_116293919	0.08	CASQ2	calsequestrin 2 (cardiac muscle)	17492	0.24
chr9_132830835_132830986	0.08	GPR107	G protein-coupled receptor 107	14925	0.18
chr4_6918537_6918793	0.08	TBC1D14	TBC1 domain family, member 14	6690	0.19
chr11_77167116_77167267	0.08	DKFZP434E1119		17225	0.19
chr15_43531850_43532099	0.08	ENSG00000202211	.	7904	0.13
chr17_8076861_8077643	0.08	ENSG00000200463	.	347	0.7
chr20_48962765_48962916	0.08	ENSG00000244376	.	83180	0.09
chr12_54693479_54693635	0.08	NFE2	nuclear factor, erythroid 2	1242	0.21
chr5_10635367_10635573	0.08	ANKRD33B-AS1	ANKRD33B antisense RNA 1	7133	0.25
chr5_163147994_163148145	0.08	ENSG00000251998	.	75102	0.12
chr16_85793045_85793254	0.08	C16orf74	chromosome 16 open reading frame 74	8414	0.11
chr12_15113710_15114247	0.08	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	222	0.92
chr19_50269466_50269673	0.08	AP2A1	adaptor-related protein complex 2, alpha 1 subunit	656	0.43

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TGIF1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.2	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.2	GO:0010310	regulation of hydrogen peroxide metabolic process(GO:0010310)
0.0	0.0	GO:0034113	heterotypic cell-cell adhesion(GO:0034113) regulation of heterotypic cell-cell adhesion(GO:0034114)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.1	GO:0032070	regulation of deoxyribonuclease activity(GO:0032070)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.3	GO:0006906	vesicle fusion(GO:0006906)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0090267	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.2	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.0	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.3	GO:0045576	mast cell activation(GO:0045576)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0016102	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.0	GO:0014805	smooth muscle adaptation(GO:0014805)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0006388	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.0	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.0	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0032747	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0	0.1	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0031017	exocrine pancreas development(GO:0031017)
0.0	0.1	GO:0002467	germinal center formation(GO:0002467)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.0	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.0	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.0	GO:0001865	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.0	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.0	GO:1903960	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.0	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:0031297	replication fork processing(GO:0031297)
0.0	0.0	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.0	GO:0032490	detection of molecule of bacterial origin(GO:0032490)
0.0	0.0	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.1	GO:0072487	MSL complex(GO:0072487)
0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	GO:0071942	XPC complex(GO:0071942)
0.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.1	GO:0042599	lamellar body(GO:0042599)
0.1	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.1	GO:0070695	FHF complex(GO:0070695)
0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	GO:0044462	external encapsulating structure part(GO:0044462)
0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.1	0.3	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.1	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.0	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.0	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.0	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.2	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.0	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.0	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.0	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.2	GO:0000030	mannosyltransferase activity(GO:0000030)
0.0	0.1	GO:0001848	complement binding(GO:0001848)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.0	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.3	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.6	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi