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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for THRA_RXRB

Z-value: 0.80

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Transcription factors associated with THRA_RXRB

Gene Symbol Gene ID Gene Info
THRA
ENSG00000126351.8 thyroid hormone receptor alpha
RXRB
ENSG00000204231.6 retinoid X receptor beta

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr17_38214670_38214853THRA2180.876638-0.771.5e-02Click!
chr17_38215195_38215346THRA7270.511622-0.665.1e-02Click!
chr17_38224700_38225305THRA1540.9258720.665.4e-02Click!
chr17_38228617_38228812THRA3700.788671-0.637.1e-02Click!
chr17_38221376_38221734THRA24030.180628-0.627.7e-02Click!

Activity of the THRA_RXRB motif across conditions

Conditions sorted by the z-value of the THRA_RXRB motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr8_134086172_134086360 0.61 SLA
 Src-like-adaptor
 13663
 0.23
chr13_114428625_114429103 0.61 TMEM255B
 transmembrane protein 255B
 33352
 0.18
chr16_28306637_28306788 0.61 SBK1
 SH3 domain binding kinase 1
 2872
 0.28
chr1_206732914_206733127 0.60 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 2527
 0.25
chr6_154566868_154567140 0.54 IPCEF1
 interaction protein for cytohesin exchange factors 1
 986
 0.71
chr3_50646296_50646682 0.51 CISH
 cytokine inducible SH2-containing protein
 2714
 0.2
chr17_8867884_8868296 0.49 PIK3R5
 phosphoinositide-3-kinase, regulatory subunit 5
 934
 0.65
chr3_183273082_183273407 0.49 KLHL6
 kelch-like family member 6
 233
 0.92
chr18_43267753_43268033 0.46 SLC14A2
 solute carrier family 14 (urea transporter), member 2
 21786
 0.17
chr5_81074467_81075538 0.45 SSBP2
 single-stranded DNA binding protein 2
 27930
 0.25
chr5_150593652_150593827 0.44 GM2A
 GM2 ganglioside activator
 2028
 0.31
chr6_128221812_128222507 0.44 THEMIS
 thymocyte selection associated
 56
 0.99
chr14_22964891_22965136 0.43 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 8842
 0.1
chr11_104904746_104905919 0.43 CASP1
 caspase 1, apoptosis-related cysteine peptidase
 508
 0.77
chr2_68963054_68963510 0.40 ARHGAP25
 Rho GTPase activating protein 25
 1268
 0.56
chr20_827167_827339 0.40 FAM110A
 family with sequence similarity 110, member A
 1486
 0.47
chr2_74433191_74433522 0.40 MTHFD2
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
 7613
 0.14
chr1_154984608_154984759 0.40 ZBTB7B
 zinc finger and BTB domain containing 7B
 2241
 0.12
chr8_134084504_134084857 0.39 SLA
 Src-like-adaptor
 12077
 0.24
chr22_50631230_50631436 0.39 TRABD
 TraB domain containing
 110
 0.82
chr14_22987545_22987798 0.39 TRAJ15
 T cell receptor alpha joining 15
 10909
 0.1
chr17_56410108_56410593 0.38 MIR142
 microRNA 142
 481
 0.66
chr1_40849833_40850457 0.38 SMAP2
 small ArfGAP2
 9825
 0.18
chr11_95420136_95420287 0.37 FAM76B
 family with sequence similarity 76, member B
 99758
 0.08
chr13_114428270_114428568 0.36 TMEM255B
 transmembrane protein 255B
 33797
 0.18
chr2_127422219_127422370 0.36 GYPC
 glycophorin C (Gerbich blood group)
 8534
 0.27
chr2_231588412_231588687 0.36 CAB39
 calcium binding protein 39
 10286
 0.21
chr1_39680841_39681106 0.35 RP11-416A14.1
8789
 0.18
chrY_14775150_14775569 0.35 USP9Y
 ubiquitin specific peptidase 9, Y-linked
 37801
 0.23
chr16_28305279_28305430 0.35 SBK1
 SH3 domain binding kinase 1
 1514
 0.42
chr17_40439817_40440043 0.34 STAT5A
 signal transducer and activator of transcription 5A
 45
 0.96
chr22_47070453_47070681 0.34 GRAMD4
 GRAM domain containing 4
 62
 0.98
chr7_142495656_142495944 0.34 PRSS3P2
 protease, serine, 3 pseudogene 2
 14669
 0.17
chr12_55377683_55377834 0.33 TESPA1
 thymocyte expressed, positive selection associated 1
 698
 0.74
chr17_56413846_56414087 0.33 ENSG00000264399
 .
 583
 0.4
chr1_1830918_1831069 0.33 RP1-140A9.1
8083
 0.13
chr18_21581201_21581352 0.33 TTC39C
 tetratricopeptide repeat domain 39C
 8539
 0.18
chr16_3627016_3627406 0.33 NLRC3
 NLR family, CARD domain containing 3
 181
 0.93
chr12_15113209_15113383 0.33 ARHGDIB
 Rho GDP dissociation inhibitor (GDI) beta
 904
 0.55
chr2_86088659_86088948 0.32 ST3GAL5
 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
 5974
 0.2
chr15_65185686_65185837 0.32 ENSG00000264929
 .
 6677
 0.16
chrX_118825837_118826063 0.32 SEPT6
 septin 6
 842
 0.6
chr2_70321532_70321889 0.31 PCBP1-AS1
 PCBP1 antisense RNA 1
 5732
 0.17
chr12_122230087_122230336 0.31 RHOF
 ras homolog family member F (in filopodia)
 1055
 0.48
chr9_132650530_132650755 0.30 FNBP1
 formin binding protein 1
 30947
 0.13
chr6_53209040_53209191 0.30 ELOVL5
 ELOVL fatty acid elongase 5
 4472
 0.24
chr13_31309265_31309542 0.30 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 242
 0.96
chr8_22976794_22976945 0.30 TNFRSF10C
 tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
 16435
 0.13
chr11_3969184_3969451 0.29 STIM1
 stromal interaction molecule 1
 744
 0.65
chr19_48760988_48761397 0.29 CARD8
 caspase recruitment domain family, member 8
 1989
 0.2
chr1_208040719_208040870 0.29 CD34
 CD34 molecule
 23043
 0.23
chr4_109082592_109082835 0.29 LEF1
 lymphoid enhancer-binding factor 1
 4744
 0.25
chr11_18267936_18268087 0.29 SAA2
 serum amyloid A2
 1555
 0.21
chr11_118210860_118211247 0.28 CD3D
 CD3d molecule, delta (CD3-TCR complex)
 599
 0.61
chr6_10529624_10529892 0.28 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
 1169
 0.49
chr1_74475780_74475968 0.28 LRRIQ3
 leucine-rich repeats and IQ motif containing 3
 64600
 0.13
chr19_10842481_10842632 0.28 DNM2
 dynamin 2
 13319
 0.11
chr17_73840046_73840332 0.28 UNC13D
 unc-13 homolog D (C. elegans)
 226
 0.84
chr18_2981073_2981432 0.28 LPIN2
 lipin 2
 1619
 0.33
chr17_45811642_45811793 0.28 TBX21
 T-box 21
 1107
 0.44
chrX_48793999_48794379 0.28 PIM2
 pim-2 oncogene
 17888
 0.08
chr11_104915569_104916017 0.28 CARD16
 caspase recruitment domain family, member 16
 241
 0.92
chr10_15296464_15296906 0.28 RP11-25G10.2
17194
 0.24
chr2_162929797_162930173 0.27 AC008063.2
219
 0.89
chr11_67186305_67186456 0.27 PPP1CA
 protein phosphatase 1, catalytic subunit, alpha isozyme
 2272
 0.11
chr12_51716594_51716774 0.27 BIN2
 bridging integrator 2
 1215
 0.42
chr8_27236010_27236326 0.27 PTK2B
 protein tyrosine kinase 2 beta
 2000
 0.39
chr1_117306495_117306758 0.27 CD2
 CD2 molecule
 9537
 0.22
chrY_7140936_7141087 0.27 PRKY
 protein kinase, Y-linked, pseudogene
 1325
 0.53
chr20_56202934_56203085 0.27 ZBP1
 Z-DNA binding protein 1
 7377
 0.24
chr14_91854852_91855042 0.27 CCDC88C
 coiled-coil domain containing 88C
 28743
 0.19
chr11_76794049_76794313 0.27 CAPN5
 calpain 5
 16141
 0.16
chr5_176859853_176860004 0.27 GRK6
 G protein-coupled receptor kinase 6
 6073
 0.1
chr13_41187779_41187930 0.26 FOXO1
 forkhead box O1
 52880
 0.14
chr5_79487674_79487825 0.26 ENSG00000239159
 .
 47659
 0.12
chr12_25204773_25204947 0.26 LRMP
 lymphoid-restricted membrane protein
 345
 0.89
chr8_144107989_144108192 0.26 LY6E
 lymphocyte antigen 6 complex, locus E
 8116
 0.17
chr16_85979656_85979807 0.26 IRF8
 interferon regulatory factor 8
 31812
 0.2
chr5_95171463_95171720 0.26 GLRX
 glutaredoxin (thioltransferase)
 12882
 0.13
chr5_159713959_159714110 0.26 ENSG00000243654
 .
 4761
 0.2
chrX_105621857_105622008 0.25 ENSG00000202407
 .
 47866
 0.19
chr7_26704596_26704975 0.25 C7orf71
 chromosome 7 open reading frame 71
 27295
 0.23
chr9_123688442_123688941 0.25 TRAF1
 TNF receptor-associated factor 1
 2356
 0.33
chr6_29911310_29911740 0.25 HLA-A
 major histocompatibility complex, class I, A
 1199
 0.47
chr16_84641211_84641362 0.25 COTL1
 coactosin-like 1 (Dictyostelium)
 10379
 0.17
chr15_64984890_64985206 0.25 AC100830.4
2192
 0.18
chr6_117870110_117870478 0.25 GOPC
 golgi-associated PDZ and coiled-coil motif containing
 53233
 0.12
chr16_85768972_85769153 0.24 ENSG00000222190
 .
 6244
 0.13
chr8_8777943_8778119 0.24 ENSG00000200713
 .
 24708
 0.16
chr17_2717574_2718059 0.24 RAP1GAP2
 RAP1 GTPase activating protein 2
 18040
 0.17
chr5_133458466_133458617 0.24 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 768
 0.69
chr17_76123369_76123520 0.24 TMC6
 transmembrane channel-like 6
 343
 0.8
chr13_100072035_100072186 0.24 ENSG00000266207
 .
 33613
 0.16
chr10_45874852_45875003 0.24 ALOX5
 arachidonate 5-lipoxygenase
 5252
 0.27
chr2_238166258_238166409 0.24 AC112715.2
 Uncharacterized protein
 599
 0.83
chr2_198167316_198167467 0.24 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 148
 0.95
chr13_46745397_46745548 0.24 ENSG00000240767
 .
 1589
 0.32
chr11_104970539_104970718 0.24 CASP1
 caspase 1, apoptosis-related cysteine peptidase
 1530
 0.24
chr14_22997122_22997273 0.24 TRAJ15
 T cell receptor alpha joining 15
 1383
 0.28
chr12_50561431_50561798 0.24 CERS5
 ceramide synthase 5
 409
 0.77
chr14_52818673_52818824 0.23 PTGER2
 prostaglandin E receptor 2 (subtype EP2), 53kDa
 37635
 0.19
chr11_104940583_104940734 0.23 CARD16
 caspase recruitment domain family, member 16
 24555
 0.15
chr7_26332543_26332766 0.23 SNX10
 sorting nexin 10
 20
 0.98
chr19_14496223_14496374 0.23 CD97
 CD97 molecule
 4042
 0.17
chr7_5183321_5183472 0.23 ZNF890P
 zinc finger protein 890, pseudogene
 15970
 0.17
chr7_37393476_37393702 0.23 ELMO1
 engulfment and cell motility 1
 317
 0.89
chr17_79259389_79259896 0.23 SLC38A10
 solute carrier family 38, member 10
 3578
 0.16
chr3_53205926_53206171 0.23 PRKCD
 protein kinase C, delta
 6903
 0.18
chr2_202125315_202125762 0.23 CASP8
 caspase 8, apoptosis-related cysteine peptidase
 315
 0.9
chr5_176857238_176857389 0.23 GRK6
 G protein-coupled receptor kinase 6
 3458
 0.12
chr22_50752772_50753385 0.22 XX-C283C717.1
18
 0.95
chr1_234749993_234750144 0.22 IRF2BP2
 interferon regulatory factor 2 binding protein 2
 4797
 0.21
chr19_10714199_10714545 0.22 SLC44A2
 solute carrier family 44 (choline transporter), member 2
 1186
 0.31
chr12_9912992_9913534 0.22 CD69
 CD69 molecule
 234
 0.92
chr22_47131590_47131741 0.22 CERK
 ceramide kinase
 2439
 0.28
chr17_47816551_47816978 0.22 FAM117A
 family with sequence similarity 117, member A
 14875
 0.14
chr7_38313129_38313494 0.22 STARD3NL
 STARD3 N-terminal like
 95314
 0.09
chr1_236101843_236102121 0.21 ENSG00000206803
 .
 23267
 0.18
chr14_94437286_94437966 0.21 ASB2
 ankyrin repeat and SOCS box containing 2
 2803
 0.22
chr12_54718303_54718481 0.21 COPZ1
 coatomer protein complex, subunit zeta 1
 519
 0.57
chr6_30460368_30460519 0.21 HLA-E
 major histocompatibility complex, class I, E
 3199
 0.18
chr19_18388821_18388972 0.21 JUND
 jun D proto-oncogene
 2843
 0.13
chr18_77163060_77163265 0.21 NFATC1
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
 2770
 0.33
chr19_49838375_49839003 0.21 CD37
 CD37 molecule
 5
 0.95
chr8_23075544_23076103 0.21 ENSG00000246582
 .
 6161
 0.12
chr14_24640773_24641022 0.21 REC8
 REC8 meiotic recombination protein
 165
 0.84
chr1_9486725_9486876 0.21 ENSG00000252956
 .
 11037
 0.24
chr12_12223823_12224258 0.21 BCL2L14
 BCL2-like 14 (apoptosis facilitator)
 167
 0.97
chr17_72459969_72460120 0.21 CD300A
 CD300a molecule
 2511
 0.22
chr5_133467374_133467525 0.21 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 8140
 0.21
chr10_107262399_107262550 0.21 ENSG00000207068
 .
 31943
 0.26
chr17_33672914_33673171 0.21 SLFN11
 schlafen family member 11
 7108
 0.2
chr1_46153318_46153689 0.21 TMEM69
 transmembrane protein 69
 617
 0.57
chr1_111162215_111162656 0.20 KCNA2
 potassium voltage-gated channel, shaker-related subfamily, member 2
 11661
 0.19
chr1_160709134_160709343 0.20 SLAMF7
 SLAM family member 7
 144
 0.95
chr21_46347092_46347406 0.20 ITGB2
 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
 1384
 0.25
chr21_40176782_40176933 0.20 ETS2
 v-ets avian erythroblastosis virus E26 oncogene homolog 2
 374
 0.92
chr20_49548700_49548918 0.20 ADNP
 activity-dependent neuroprotector homeobox
 851
 0.42
chr12_54610003_54610573 0.20 ENSG00000265371
 .
 14972
 0.1
chr16_30196259_30196584 0.20 RP11-455F5.5
143
 0.71
chr19_57100792_57100943 0.20 ZNF71
 zinc finger protein 71
 5765
 0.14
chr2_149285721_149285937 0.20 MBD5
 methyl-CpG binding domain protein 5
 59535
 0.15
chr5_156693510_156694312 0.20 CTC-248O19.1
276
 0.76
chr17_41445494_41445820 0.20 ENSG00000188825
 .
 19128
 0.11
chr16_1014386_1014626 0.20 LMF1
 lipase maturation factor 1
 384
 0.78
chr10_75716254_75716492 0.20 C10orf55
 chromosome 10 open reading frame 55
 33838
 0.11
chr2_26635298_26635481 0.19 DRC1
 dynein regulatory complex subunit 1 homolog (Chlamydomonas)
 10605
 0.21
chr11_64631996_64632371 0.19 EHD1
 EH-domain containing 1
 10955
 0.1
chrX_152200996_152201209 0.19 PNMA3
 paraneoplastic Ma antigen 3
 23664
 0.12
chr1_34542680_34542831 0.19 ENSG00000201148
 .
 35795
 0.19
chr9_138999016_138999167 0.19 C9orf69
 chromosome 9 open reading frame 69
 11029
 0.19
chr19_17516551_17516849 0.19 MVB12A
 multivesicular body subunit 12A
 150
 0.6
chr9_134273565_134273749 0.19 PRRC2B
 proline-rich coiled-coil 2B
 4177
 0.25
chr1_160489868_160490211 0.19 SLAMF6
 SLAM family member 6
 2993
 0.18
chr6_13274566_13274804 0.19 RP1-257A7.4
394
 0.82
chr12_9800952_9801457 0.19 RP11-705C15.4
599
 0.62
chr8_82022969_82023806 0.19 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 916
 0.72
chr1_29253197_29253478 0.19 EPB41
 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
 12246
 0.18
chr20_61407912_61408071 0.18 LINC00659
 long intergenic non-protein coding RNA 659
 1227
 0.34
chr3_71115551_71115702 0.18 FOXP1
 forkhead box P1
 708
 0.81
chr6_37141288_37141439 0.18 PIM1
 pim-1 oncogene
 3384
 0.23
chr14_90866152_90866669 0.18 CALM1
 calmodulin 1 (phosphorylase kinase, delta)
 1804
 0.32
chr19_54875923_54876565 0.18 LAIR1
 leukocyte-associated immunoglobulin-like receptor 1
 170
 0.91
chrX_123481870_123482040 0.18 SH2D1A
 SH2 domain containing 1A
 1516
 0.57
chr11_14995196_14995439 0.18 CALCA
 calcitonin-related polypeptide alpha
 1417
 0.53
chr17_76642017_76642260 0.18 ENSG00000252391
 .
 50741
 0.12
chr3_194871620_194871771 0.18 XXYLT1-AS2
 XXYLT1 antisense RNA 2
 3075
 0.19
chr13_30510013_30510639 0.18 LINC00572
 long intergenic non-protein coding RNA 572
 9538
 0.3
chr19_16477276_16478284 0.18 EPS15L1
 epidermal growth factor receptor pathway substrate 15-like 1
 5016
 0.17
chr9_130731987_130732222 0.18 FAM102A
 family with sequence similarity 102, member A
 10688
 0.11
chr8_103898951_103899102 0.18 KB-1507C5.3
5078
 0.18
chr20_33680803_33681037 0.18 TRPC4AP
 transient receptor potential cation channel, subfamily C, member 4 associated protein
 246
 0.9
chr1_111745814_111746254 0.18 DENND2D
 DENN/MADD domain containing 2D
 997
 0.41
chr6_144665292_144666004 0.18 UTRN
 utrophin
 411
 0.88
chr17_38018344_38018495 0.18 IKZF3
 IKAROS family zinc finger 3 (Aiolos)
 1960
 0.26
chr17_18161547_18161698 0.18 FLII
 flightless I homolog (Drosophila)
 248
 0.85
chr15_38853827_38853978 0.18 RASGRP1
 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
 1422
 0.42
chr17_36859477_36859845 0.18 ENSG00000265930
 .
 1077
 0.24
chr14_25142934_25143265 0.18 GZMB
 granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
 39626
 0.14
chr17_33567122_33567465 0.18 RP11-799D4.4
2293
 0.22
chr1_117343275_117343583 0.17 CD2
 CD2 molecule
 46340
 0.14
chr10_14606149_14606418 0.17 FAM107B
 family with sequence similarity 107, member B
 7746
 0.26
chr5_180633345_180633855 0.17 CTC-338M12.1
480
 0.54
chr20_35203812_35203967 0.17 TGIF2
 TGFB-induced factor homeobox 2
 814
 0.36
chr14_22963495_22963646 0.17 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 7399
 0.11
chr16_81503920_81504132 0.17 CMIP
 c-Maf inducing protein
 24928
 0.22
chr7_50357605_50357756 0.17 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 9362
 0.29
chr2_45169165_45169332 0.17 SIX3-AS1
 SIX3 antisense RNA 1
 236
 0.62
chr1_29254208_29254684 0.17 EPB41
 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
 13355
 0.18
chr17_44269690_44270135 0.17 KANSL1
 KAT8 regulatory NSL complex subunit 1
 254
 0.85
chr3_69247967_69248118 0.17 FRMD4B
 FERM domain containing 4B
 379
 0.9
chr7_99765104_99765382 0.17 GAL3ST4
 galactose-3-O-sulfotransferase 4
 336
 0.69
chr20_47382876_47383027 0.17 ENSG00000251876
 .
 26966
 0.22
chr8_33371053_33371277 0.17 TTI2
 TELO2 interacting protein 2
 46
 0.66
chr4_143741757_143741908 0.17 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 25611
 0.28
chr2_143934931_143935154 0.17 RP11-190J23.1
5301
 0.3
chr8_134079225_134079805 0.17 SLA
 Src-like-adaptor
 6912
 0.26
chr19_6802455_6802606 0.17 VAV1
 vav 1 guanine nucleotide exchange factor
 18401
 0.13
chr6_168501309_168501460 0.17 FRMD1
 FERM domain containing 1
 19147
 0.25
chr14_22963855_22964006 0.17 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 7759
 0.1

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1 0.3 GO:0033023 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 0.3 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.2 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1 0.2 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.8 GO:0043368 positive T cell selection(GO:0043368)
0.1 0.4 GO:0070670 response to interleukin-4(GO:0070670)
0.1 0.2 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.2 GO:0045056 transcytosis(GO:0045056)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.4 GO:0002467 germinal center formation(GO:0002467)
0.0 0.2 GO:0046719 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.1 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.1 GO:0001845 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0 0.2 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.2 GO:0006863 purine nucleobase transport(GO:0006863)
0.0 0.0 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.2 GO:0032814 regulation of natural killer cell activation(GO:0032814)
0.0 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0015840 urea transport(GO:0015840)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.1 GO:0019322 pentose biosynthetic process(GO:0019322)
0.0 0.1 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0 0.1 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.0 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.2 GO:0010324 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.2 GO:0007141 male meiosis I(GO:0007141)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0 0.1 GO:0046471 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0 0.1 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.0 GO:0001866 NK T cell proliferation(GO:0001866) NK T cell activation(GO:0051132)
0.0 0.1 GO:0017000 antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0 0.1 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.2 GO:0002639 positive regulation of immunoglobulin production(GO:0002639)
0.0 0.0 GO:0048305 immunoglobulin secretion(GO:0048305) regulation of immunoglobulin secretion(GO:0051023)
0.0 0.1 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.7 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.0 GO:0032527 protein exit from endoplasmic reticulum(GO:0032527)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.1 GO:0051383 kinetochore organization(GO:0051383)
0.0 0.1 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781)
0.0 0.2 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.0 0.0 GO:0070266 necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0 0.1 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.0 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.2 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0040023 establishment of nucleus localization(GO:0040023)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.1 GO:0019054 modulation by virus of host process(GO:0019054) modulation by symbiont of host cellular process(GO:0044068)
0.0 0.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.1 GO:0045885 obsolete positive regulation of survival gene product expression(GO:0045885)
0.0 0.0 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.0 0.0 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 0.1 GO:0045954 positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0000303 response to superoxide(GO:0000303)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.0 0.1 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.1 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0 0.0 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.0 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.0 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0 1.2 GO:0050851 antigen receptor-mediated signaling pathway(GO:0050851)
0.0 0.1 GO:0031529 ruffle organization(GO:0031529)
0.0 0.0 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.0 GO:2000300 regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.0 GO:0042663 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.1 GO:0042559 pteridine-containing compound biosynthetic process(GO:0042559)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.0 GO:0006922 obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0 0.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0 0.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.0 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0090116 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.0 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0 0.0 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.0 GO:0002874 chronic inflammatory response to antigenic stimulus(GO:0002439) regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.0 GO:0031062 positive regulation of histone methylation(GO:0031062)
0.0 0.0 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.0 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.0 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.0 GO:0032097 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0 0.0 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.2 GO:0007032 endosome organization(GO:0007032)
0.0 0.1 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.0 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.0 GO:0097502 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0 0.1 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0044065 regulation of respiratory system process(GO:0044065)
0.0 0.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.0 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.0 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.0 GO:0035610 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.0 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.1 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.0 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.2 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.2 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.3 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.0 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0033011 perinuclear theca(GO:0033011)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.1 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.2 GO:0032156 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.2 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.1 GO:0030312 external encapsulating structure(GO:0030312)
0.0 0.1 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.0 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.0 GO:0031501 mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.0 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.3 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.8 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.2 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.3 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.0 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.0 GO:0019959 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.0 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.0 0.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.0 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.0 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.0 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0008159 obsolete positive transcription elongation factor activity(GO:0008159)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0008494 translation activator activity(GO:0008494)
0.0 0.0 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.0 GO:0004476 mannose-6-phosphate isomerase activity(GO:0004476)
0.0 0.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.0 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.0 GO:0004803 transposase activity(GO:0004803)
0.0 0.0 GO:0005131 growth hormone receptor binding(GO:0005131)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.6 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.5 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.5 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.3 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.2 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.0 ST ADRENERGIC Adrenergic Pathway
0.0 0.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.6 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.1 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.1 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC