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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for THRA_RXRB

Z-value: 0.80

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Transcription factors associated with THRA_RXRB

Gene Symbol	Gene ID	Gene Info
THRA Ensembl NCBI GeneCards UniProt	ENSG00000126351.8	THRA
RXRB Ensembl NCBI GeneCards UniProt	ENSG00000204231.6	RXRB

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
THRA	chr17_38214670_38214853	218	0.876638	-0.77	1.5e-02	Click!
THRA	chr17_38215195_38215346	727	0.511622	-0.66	5.1e-02	Click!
THRA	chr17_38224700_38225305	154	0.925872	0.66	5.4e-02	Click!
THRA	chr17_38228617_38228812	370	0.788671	-0.63	7.1e-02	Click!
THRA	chr17_38221376_38221734	2403	0.180628	-0.62	7.7e-02	Click!

Activity of the THRA_RXRB motif across conditions

Conditions sorted by the z-value of the THRA_RXRB motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_134086172_134086360	0.61	SLA	Src-like-adaptor	13663	0.23
chr13_114428625_114429103	0.61	TMEM255B	transmembrane protein 255B	33352	0.18
chr16_28306637_28306788	0.61	SBK1	SH3 domain binding kinase 1	2872	0.28
chr1_206732914_206733127	0.60	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	2527	0.25
chr6_154566868_154567140	0.54	IPCEF1	interaction protein for cytohesin exchange factors 1	986	0.71
chr3_50646296_50646682	0.51	CISH	cytokine inducible SH2-containing protein	2714	0.2
chr17_8867884_8868296	0.49	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	934	0.65
chr3_183273082_183273407	0.49	KLHL6	kelch-like family member 6	233	0.92
chr18_43267753_43268033	0.46	SLC14A2	solute carrier family 14 (urea transporter), member 2	21786	0.17
chr5_81074467_81075538	0.45	SSBP2	single-stranded DNA binding protein 2	27930	0.25
chr5_150593652_150593827	0.44	GM2A	GM2 ganglioside activator	2028	0.31
chr6_128221812_128222507	0.44	THEMIS	thymocyte selection associated	56	0.99
chr14_22964891_22965136	0.43	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	8842	0.1
chr11_104904746_104905919	0.43	CASP1	caspase 1, apoptosis-related cysteine peptidase	508	0.77
chr2_68963054_68963510	0.40	ARHGAP25	Rho GTPase activating protein 25	1268	0.56
chr20_827167_827339	0.40	FAM110A	family with sequence similarity 110, member A	1486	0.47
chr2_74433191_74433522	0.40	MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	7613	0.14
chr1_154984608_154984759	0.40	ZBTB7B	zinc finger and BTB domain containing 7B	2241	0.12
chr8_134084504_134084857	0.39	SLA	Src-like-adaptor	12077	0.24
chr22_50631230_50631436	0.39	TRABD	TraB domain containing	110	0.82
chr14_22987545_22987798	0.39	TRAJ15	T cell receptor alpha joining 15	10909	0.1
chr17_56410108_56410593	0.38	MIR142	microRNA 142	481	0.66
chr1_40849833_40850457	0.38	SMAP2	small ArfGAP2	9825	0.18
chr11_95420136_95420287	0.37	FAM76B	family with sequence similarity 76, member B	99758	0.08
chr13_114428270_114428568	0.36	TMEM255B	transmembrane protein 255B	33797	0.18
chr2_127422219_127422370	0.36	GYPC	glycophorin C (Gerbich blood group)	8534	0.27
chr2_231588412_231588687	0.36	CAB39	calcium binding protein 39	10286	0.21
chr1_39680841_39681106	0.35	RP11-416A14.1		8789	0.18
chrY_14775150_14775569	0.35	USP9Y	ubiquitin specific peptidase 9, Y-linked	37801	0.23
chr16_28305279_28305430	0.35	SBK1	SH3 domain binding kinase 1	1514	0.42
chr17_40439817_40440043	0.34	STAT5A	signal transducer and activator of transcription 5A	45	0.96
chr22_47070453_47070681	0.34	GRAMD4	GRAM domain containing 4	62	0.98
chr7_142495656_142495944	0.34	PRSS3P2	protease, serine, 3 pseudogene 2	14669	0.17
chr12_55377683_55377834	0.33	TESPA1	thymocyte expressed, positive selection associated 1	698	0.74
chr17_56413846_56414087	0.33	ENSG00000264399	.	583	0.4
chr1_1830918_1831069	0.33	RP1-140A9.1		8083	0.13
chr18_21581201_21581352	0.33	TTC39C	tetratricopeptide repeat domain 39C	8539	0.18
chr16_3627016_3627406	0.33	NLRC3	NLR family, CARD domain containing 3	181	0.93
chr12_15113209_15113383	0.33	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	904	0.55
chr2_86088659_86088948	0.32	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	5974	0.2
chr15_65185686_65185837	0.32	ENSG00000264929	.	6677	0.16
chrX_118825837_118826063	0.32	SEPT6	septin 6	842	0.6
chr2_70321532_70321889	0.31	PCBP1-AS1	PCBP1 antisense RNA 1	5732	0.17
chr12_122230087_122230336	0.31	RHOF	ras homolog family member F (in filopodia)	1055	0.48
chr9_132650530_132650755	0.30	FNBP1	formin binding protein 1	30947	0.13
chr6_53209040_53209191	0.30	ELOVL5	ELOVL fatty acid elongase 5	4472	0.24
chr13_31309265_31309542	0.30	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	242	0.96
chr8_22976794_22976945	0.30	TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	16435	0.13
chr11_3969184_3969451	0.29	STIM1	stromal interaction molecule 1	744	0.65
chr19_48760988_48761397	0.29	CARD8	caspase recruitment domain family, member 8	1989	0.2
chr1_208040719_208040870	0.29	CD34	CD34 molecule	23043	0.23
chr4_109082592_109082835	0.29	LEF1	lymphoid enhancer-binding factor 1	4744	0.25
chr11_18267936_18268087	0.29	SAA2	serum amyloid A2	1555	0.21
chr11_118210860_118211247	0.28	CD3D	CD3d molecule, delta (CD3-TCR complex)	599	0.61
chr6_10529624_10529892	0.28	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	1169	0.49
chr1_74475780_74475968	0.28	LRRIQ3	leucine-rich repeats and IQ motif containing 3	64600	0.13
chr19_10842481_10842632	0.28	DNM2	dynamin 2	13319	0.11
chr17_73840046_73840332	0.28	UNC13D	unc-13 homolog D (C. elegans)	226	0.84
chr18_2981073_2981432	0.28	LPIN2	lipin 2	1619	0.33
chr17_45811642_45811793	0.28	TBX21	T-box 21	1107	0.44
chrX_48793999_48794379	0.28	PIM2	pim-2 oncogene	17888	0.08
chr11_104915569_104916017	0.28	CARD16	caspase recruitment domain family, member 16	241	0.92
chr10_15296464_15296906	0.28	RP11-25G10.2		17194	0.24
chr2_162929797_162930173	0.27	AC008063.2		219	0.89
chr11_67186305_67186456	0.27	PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	2272	0.11
chr12_51716594_51716774	0.27	BIN2	bridging integrator 2	1215	0.42
chr8_27236010_27236326	0.27	PTK2B	protein tyrosine kinase 2 beta	2000	0.39
chr1_117306495_117306758	0.27	CD2	CD2 molecule	9537	0.22
chrY_7140936_7141087	0.27	PRKY	protein kinase, Y-linked, pseudogene	1325	0.53
chr20_56202934_56203085	0.27	ZBP1	Z-DNA binding protein 1	7377	0.24
chr14_91854852_91855042	0.27	CCDC88C	coiled-coil domain containing 88C	28743	0.19
chr11_76794049_76794313	0.27	CAPN5	calpain 5	16141	0.16
chr5_176859853_176860004	0.27	GRK6	G protein-coupled receptor kinase 6	6073	0.1
chr13_41187779_41187930	0.26	FOXO1	forkhead box O1	52880	0.14
chr5_79487674_79487825	0.26	ENSG00000239159	.	47659	0.12
chr12_25204773_25204947	0.26	LRMP	lymphoid-restricted membrane protein	345	0.89
chr8_144107989_144108192	0.26	LY6E	lymphocyte antigen 6 complex, locus E	8116	0.17
chr16_85979656_85979807	0.26	IRF8	interferon regulatory factor 8	31812	0.2
chr5_95171463_95171720	0.26	GLRX	glutaredoxin (thioltransferase)	12882	0.13
chr5_159713959_159714110	0.26	ENSG00000243654	.	4761	0.2
chrX_105621857_105622008	0.25	ENSG00000202407	.	47866	0.19
chr7_26704596_26704975	0.25	C7orf71	chromosome 7 open reading frame 71	27295	0.23
chr9_123688442_123688941	0.25	TRAF1	TNF receptor-associated factor 1	2356	0.33
chr6_29911310_29911740	0.25	HLA-A	major histocompatibility complex, class I, A	1199	0.47
chr16_84641211_84641362	0.25	COTL1	coactosin-like 1 (Dictyostelium)	10379	0.17
chr15_64984890_64985206	0.25	AC100830.4		2192	0.18
chr6_117870110_117870478	0.25	GOPC	golgi-associated PDZ and coiled-coil motif containing	53233	0.12
chr16_85768972_85769153	0.24	ENSG00000222190	.	6244	0.13
chr8_8777943_8778119	0.24	ENSG00000200713	.	24708	0.16
chr17_2717574_2718059	0.24	RAP1GAP2	RAP1 GTPase activating protein 2	18040	0.17
chr5_133458466_133458617	0.24	TCF7	transcription factor 7 (T-cell specific, HMG-box)	768	0.69
chr17_76123369_76123520	0.24	TMC6	transmembrane channel-like 6	343	0.8
chr13_100072035_100072186	0.24	ENSG00000266207	.	33613	0.16
chr10_45874852_45875003	0.24	ALOX5	arachidonate 5-lipoxygenase	5252	0.27
chr2_238166258_238166409	0.24	AC112715.2	Uncharacterized protein	599	0.83
chr2_198167316_198167467	0.24	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	148	0.95
chr13_46745397_46745548	0.24	ENSG00000240767	.	1589	0.32
chr11_104970539_104970718	0.24	CASP1	caspase 1, apoptosis-related cysteine peptidase	1530	0.24
chr14_22997122_22997273	0.24	TRAJ15	T cell receptor alpha joining 15	1383	0.28
chr12_50561431_50561798	0.24	CERS5	ceramide synthase 5	409	0.77
chr14_52818673_52818824	0.23	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	37635	0.19
chr11_104940583_104940734	0.23	CARD16	caspase recruitment domain family, member 16	24555	0.15
chr7_26332543_26332766	0.23	SNX10	sorting nexin 10	20	0.98
chr19_14496223_14496374	0.23	CD97	CD97 molecule	4042	0.17
chr7_5183321_5183472	0.23	ZNF890P	zinc finger protein 890, pseudogene	15970	0.17
chr7_37393476_37393702	0.23	ELMO1	engulfment and cell motility 1	317	0.89
chr17_79259389_79259896	0.23	SLC38A10	solute carrier family 38, member 10	3578	0.16
chr3_53205926_53206171	0.23	PRKCD	protein kinase C, delta	6903	0.18
chr2_202125315_202125762	0.23	CASP8	caspase 8, apoptosis-related cysteine peptidase	315	0.9
chr5_176857238_176857389	0.23	GRK6	G protein-coupled receptor kinase 6	3458	0.12
chr22_50752772_50753385	0.22	XX-C283C717.1		18	0.95
chr1_234749993_234750144	0.22	IRF2BP2	interferon regulatory factor 2 binding protein 2	4797	0.21
chr19_10714199_10714545	0.22	SLC44A2	solute carrier family 44 (choline transporter), member 2	1186	0.31
chr12_9912992_9913534	0.22	CD69	CD69 molecule	234	0.92
chr22_47131590_47131741	0.22	CERK	ceramide kinase	2439	0.28
chr17_47816551_47816978	0.22	FAM117A	family with sequence similarity 117, member A	14875	0.14
chr7_38313129_38313494	0.22	STARD3NL	STARD3 N-terminal like	95314	0.09
chr1_236101843_236102121	0.21	ENSG00000206803	.	23267	0.18
chr14_94437286_94437966	0.21	ASB2	ankyrin repeat and SOCS box containing 2	2803	0.22
chr12_54718303_54718481	0.21	COPZ1	coatomer protein complex, subunit zeta 1	519	0.57
chr6_30460368_30460519	0.21	HLA-E	major histocompatibility complex, class I, E	3199	0.18
chr19_18388821_18388972	0.21	JUND	jun D proto-oncogene	2843	0.13
chr18_77163060_77163265	0.21	NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	2770	0.33
chr19_49838375_49839003	0.21	CD37	CD37 molecule	5	0.95
chr8_23075544_23076103	0.21	ENSG00000246582	.	6161	0.12
chr14_24640773_24641022	0.21	REC8	REC8 meiotic recombination protein	165	0.84
chr1_9486725_9486876	0.21	ENSG00000252956	.	11037	0.24
chr12_12223823_12224258	0.21	BCL2L14	BCL2-like 14 (apoptosis facilitator)	167	0.97
chr17_72459969_72460120	0.21	CD300A	CD300a molecule	2511	0.22
chr5_133467374_133467525	0.21	TCF7	transcription factor 7 (T-cell specific, HMG-box)	8140	0.21
chr10_107262399_107262550	0.21	ENSG00000207068	.	31943	0.26
chr17_33672914_33673171	0.21	SLFN11	schlafen family member 11	7108	0.2
chr1_46153318_46153689	0.21	TMEM69	transmembrane protein 69	617	0.57
chr1_111162215_111162656	0.20	KCNA2	potassium voltage-gated channel, shaker-related subfamily, member 2	11661	0.19
chr1_160709134_160709343	0.20	SLAMF7	SLAM family member 7	144	0.95
chr21_46347092_46347406	0.20	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	1384	0.25
chr21_40176782_40176933	0.20	ETS2	v-ets avian erythroblastosis virus E26 oncogene homolog 2	374	0.92
chr20_49548700_49548918	0.20	ADNP	activity-dependent neuroprotector homeobox	851	0.42
chr12_54610003_54610573	0.20	ENSG00000265371	.	14972	0.1
chr16_30196259_30196584	0.20	RP11-455F5.5		143	0.71
chr19_57100792_57100943	0.20	ZNF71	zinc finger protein 71	5765	0.14
chr2_149285721_149285937	0.20	MBD5	methyl-CpG binding domain protein 5	59535	0.15
chr5_156693510_156694312	0.20	CTC-248O19.1		276	0.76
chr17_41445494_41445820	0.20	ENSG00000188825	.	19128	0.11
chr16_1014386_1014626	0.20	LMF1	lipase maturation factor 1	384	0.78
chr10_75716254_75716492	0.20	C10orf55	chromosome 10 open reading frame 55	33838	0.11
chr2_26635298_26635481	0.19	DRC1	dynein regulatory complex subunit 1 homolog (Chlamydomonas)	10605	0.21
chr11_64631996_64632371	0.19	EHD1	EH-domain containing 1	10955	0.1
chrX_152200996_152201209	0.19	PNMA3	paraneoplastic Ma antigen 3	23664	0.12
chr1_34542680_34542831	0.19	ENSG00000201148	.	35795	0.19
chr9_138999016_138999167	0.19	C9orf69	chromosome 9 open reading frame 69	11029	0.19
chr19_17516551_17516849	0.19	MVB12A	multivesicular body subunit 12A	150	0.6
chr9_134273565_134273749	0.19	PRRC2B	proline-rich coiled-coil 2B	4177	0.25
chr1_160489868_160490211	0.19	SLAMF6	SLAM family member 6	2993	0.18
chr6_13274566_13274804	0.19	RP1-257A7.4		394	0.82
chr12_9800952_9801457	0.19	RP11-705C15.4		599	0.62
chr8_82022969_82023806	0.19	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	916	0.72
chr1_29253197_29253478	0.19	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12246	0.18
chr20_61407912_61408071	0.18	LINC00659	long intergenic non-protein coding RNA 659	1227	0.34
chr3_71115551_71115702	0.18	FOXP1	forkhead box P1	708	0.81
chr6_37141288_37141439	0.18	PIM1	pim-1 oncogene	3384	0.23
chr14_90866152_90866669	0.18	CALM1	calmodulin 1 (phosphorylase kinase, delta)	1804	0.32
chr19_54875923_54876565	0.18	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	170	0.91
chrX_123481870_123482040	0.18	SH2D1A	SH2 domain containing 1A	1516	0.57
chr11_14995196_14995439	0.18	CALCA	calcitonin-related polypeptide alpha	1417	0.53
chr17_76642017_76642260	0.18	ENSG00000252391	.	50741	0.12
chr3_194871620_194871771	0.18	XXYLT1-AS2	XXYLT1 antisense RNA 2	3075	0.19
chr13_30510013_30510639	0.18	LINC00572	long intergenic non-protein coding RNA 572	9538	0.3
chr19_16477276_16478284	0.18	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	5016	0.17
chr9_130731987_130732222	0.18	FAM102A	family with sequence similarity 102, member A	10688	0.11
chr8_103898951_103899102	0.18	KB-1507C5.3		5078	0.18
chr20_33680803_33681037	0.18	TRPC4AP	transient receptor potential cation channel, subfamily C, member 4 associated protein	246	0.9
chr1_111745814_111746254	0.18	DENND2D	DENN/MADD domain containing 2D	997	0.41
chr6_144665292_144666004	0.18	UTRN	utrophin	411	0.88
chr17_38018344_38018495	0.18	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1960	0.26
chr17_18161547_18161698	0.18	FLII	flightless I homolog (Drosophila)	248	0.85
chr15_38853827_38853978	0.18	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	1422	0.42
chr17_36859477_36859845	0.18	ENSG00000265930	.	1077	0.24
chr14_25142934_25143265	0.18	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	39626	0.14
chr17_33567122_33567465	0.18	RP11-799D4.4		2293	0.22
chr1_117343275_117343583	0.17	CD2	CD2 molecule	46340	0.14
chr10_14606149_14606418	0.17	FAM107B	family with sequence similarity 107, member B	7746	0.26
chr5_180633345_180633855	0.17	CTC-338M12.1		480	0.54
chr20_35203812_35203967	0.17	TGIF2	TGFB-induced factor homeobox 2	814	0.36
chr14_22963495_22963646	0.17	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	7399	0.11
chr16_81503920_81504132	0.17	CMIP	c-Maf inducing protein	24928	0.22
chr7_50357605_50357756	0.17	IKZF1	IKAROS family zinc finger 1 (Ikaros)	9362	0.29
chr2_45169165_45169332	0.17	SIX3-AS1	SIX3 antisense RNA 1	236	0.62
chr1_29254208_29254684	0.17	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	13355	0.18
chr17_44269690_44270135	0.17	KANSL1	KAT8 regulatory NSL complex subunit 1	254	0.85
chr3_69247967_69248118	0.17	FRMD4B	FERM domain containing 4B	379	0.9
chr7_99765104_99765382	0.17	GAL3ST4	galactose-3-O-sulfotransferase 4	336	0.69
chr20_47382876_47383027	0.17	ENSG00000251876	.	26966	0.22
chr8_33371053_33371277	0.17	TTI2	TELO2 interacting protein 2	46	0.66
chr4_143741757_143741908	0.17	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	25611	0.28
chr2_143934931_143935154	0.17	RP11-190J23.1		5301	0.3
chr8_134079225_134079805	0.17	SLA	Src-like-adaptor	6912	0.26
chr19_6802455_6802606	0.17	VAV1	vav 1 guanine nucleotide exchange factor	18401	0.13
chr6_168501309_168501460	0.17	FRMD1	FERM domain containing 1	19147	0.25
chr14_22963855_22964006	0.17	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	7759	0.1

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.3	GO:0033023	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1	0.3	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.2	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.2	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.8	GO:0043368	positive T cell selection(GO:0043368)
0.1	0.4	GO:0070670	response to interleukin-4(GO:0070670)
0.1	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:0045056	transcytosis(GO:0045056)
0.0	0.4	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.2	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.4	GO:0002467	germinal center formation(GO:0002467)
0.0	0.2	GO:0046719	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.0	0.1	GO:0001845	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.2	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.2	GO:0006863	purine nucleobase transport(GO:0006863)
0.0	0.0	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.0	0.1	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.2	GO:0032814	regulation of natural killer cell activation(GO:0032814)
0.0	0.1	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.2	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0019322	pentose biosynthetic process(GO:0019322)
0.0	0.1	GO:0032650	regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.1	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.0	GO:0032785	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.2	GO:0010324	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.1	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.1	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.2	GO:0007141	male meiosis I(GO:0007141)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0046902	regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0	0.1	GO:0046471	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0	0.1	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.0	GO:0001866	NK T cell proliferation(GO:0001866) NK T cell activation(GO:0051132)
0.0	0.1	GO:0017000	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.1	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.2	GO:0002639	positive regulation of immunoglobulin production(GO:0002639)
0.0	0.0	GO:0048305	immunoglobulin secretion(GO:0048305) regulation of immunoglobulin secretion(GO:0051023)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.2	GO:0006265	DNA topological change(GO:0006265)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.7	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.0	0.0	GO:0032527	protein exit from endoplasmic reticulum(GO:0032527)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0051383	kinetochore organization(GO:0051383)
0.0	0.1	GO:0015781	pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.2	GO:0050716	positive regulation of interleukin-1 secretion(GO:0050716)
0.0	0.0	GO:0070266	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.0	GO:0046549	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.2	GO:0006906	vesicle fusion(GO:0006906)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0040023	establishment of nucleus localization(GO:0040023)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0019054	modulation by virus of host process(GO:0019054) modulation by symbiont of host cellular process(GO:0044068)
0.0	0.1	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.1	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.0	GO:0071218	cellular response to misfolded protein(GO:0071218)
0.0	0.0	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
0.0	0.1	GO:0045954	positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.2	GO:0000303	response to superoxide(GO:0000303)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0010755	regulation of plasminogen activation(GO:0010755)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.2	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.0	GO:0045836	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	1.2	GO:0050851	antigen receptor-mediated signaling pathway(GO:0050851)
0.0	0.1	GO:0031529	ruffle organization(GO:0031529)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.1	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:2000300	regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0	0.0	GO:0042663	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:0042559	pteridine-containing compound biosynthetic process(GO:0042559)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.0	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0014052	regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0	0.0	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.0	GO:0002874	chronic inflammatory response to antigenic stimulus(GO:0002439) regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.2	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.0	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.0	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.0	GO:0032097	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0048205	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.1	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.2	GO:0007032	endosome organization(GO:0007032)
0.0	0.1	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.0	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0097502	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.1	GO:0006086	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0044065	regulation of respiratory system process(GO:0044065)
0.0	0.1	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.0	GO:0035610	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.0	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0	0.1	GO:0018065	protein-cofactor linkage(GO:0018065)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.2	GO:0000800	lateral element(GO:0000800)
0.0	0.1	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.2	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0071817	MMXD complex(GO:0071817)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.0	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0033011	perinuclear theca(GO:0033011)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.2	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.2	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
0.0	0.1	GO:0030312	external encapsulating structure(GO:0030312)
0.0	0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.1	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.0	GO:0031501	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.2	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.3	GO:0098636	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.2	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.8	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.2	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.2	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.4	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.2	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.3	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.8	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.8	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.3	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.0	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.0	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.0	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.0	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.0	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.1	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.0	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.2	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.0	GO:0004803	transposase activity(GO:0004803)
0.0	0.0	GO:0005131	growth hormone receptor binding(GO:0005131)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.6	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.5	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	1.5	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.7	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.5	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.3	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.2	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.2	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.0	0.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.0	ST ADRENERGIC	Adrenergic Pathway
0.0	0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.3	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.3	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.6	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.5	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.3	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.1	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.3	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.3	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.1	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC