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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for TLX1_NFIC

Z-value: 1.68

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Transcription factors associated with TLX1_NFIC

Gene Symbol	Gene ID	Gene Info
TLX1 Ensembl NCBI GeneCards UniProt	ENSG00000107807.8	TLX1
NFIC Ensembl NCBI GeneCards UniProt	ENSG00000141905.13	NFIC

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NFIC	chr19_3346811_3347036	12638	0.174757	0.85	3.4e-03	Click!
NFIC	chr19_3358174_3358371	1289	0.448410	-0.81	7.5e-03	Click!
NFIC	chr19_3363597_3363748	2875	0.254994	0.78	1.3e-02	Click!
NFIC	chr19_3397384_3397535	30875	0.133097	0.77	1.6e-02	Click!
NFIC	chr19_3368308_3368459	1799	0.345534	0.70	3.6e-02	Click!
TLX1	chr10_102894531_102894816	3612	0.145047	0.51	1.6e-01	Click!
TLX1	chr10_102894012_102894163	3026	0.156812	0.39	3.1e-01	Click!
TLX1	chr10_102895075_102895226	4089	0.138354	-0.36	3.4e-01	Click!
TLX1	chr10_102894867_102895065	3905	0.140720	0.20	6.0e-01	Click!
TLX1	chr10_102891889_102892040	903	0.360024	0.12	7.7e-01	Click!

Activity of the TLX1_NFIC motif across conditions

Conditions sorted by the z-value of the TLX1_NFIC motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_16389894_16390114	1.54	FAM211A	family with sequence similarity 211, member A	5328	0.18
chr4_158143046_158143598	1.33	GRIA2	glutamate receptor, ionotropic, AMPA 2	504	0.84
chr16_4366907_4367444	1.27	GLIS2	GLIS family zinc finger 2	2413	0.21
chr9_140506939_140507169	1.09	C9orf37	chromosome 9 open reading frame 37	6211	0.12
chr14_75421223_75421487	1.03	PGF	placental growth factor	590	0.68
chr20_45989388_45989864	1.02	ZMYND8	zinc finger, MYND-type containing 8	4059	0.17
chr5_115697275_115697566	0.99	CTB-118N6.3		85823	0.09
chr8_55294582_55295235	0.99	ENSG00000244107	.	38120	0.17
chr8_65488422_65488732	0.99	RP11-21C4.1		1243	0.52
chr1_212810031_212810274	0.98	RP11-338C15.5		10039	0.14
chr9_109459969_109460612	0.97	ENSG00000200131	.	18032	0.28
chr19_1154555_1155129	0.97	SBNO2	strawberry notch homolog 2 (Drosophila)	293	0.85
chr9_25678314_25678778	0.90	TUSC1	tumor suppressor candidate 1	310	0.95
chr10_17390339_17390851	0.87	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	21487	0.18
chr5_54734053_54734276	0.83	SKIV2L2	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	22280	0.2
chr11_63530349_63531105	0.81	ENSG00000264519	.	34816	0.12
chr7_95401616_95402462	0.80	DYNC1I1	dynein, cytoplasmic 1, intermediate chain 1	123	0.98
chr19_17953136_17953665	0.80	JAK3	Janus kinase 3	1856	0.22
chr1_113243148_113243677	0.79	RHOC	ras homolog family member C	4131	0.12
chr11_106295016_106295231	0.79	RP11-680E19.1		160081	0.04
chr2_175743189_175743666	0.78	CHN1	chimerin 1	30948	0.19
chr18_9417287_9417498	0.76	RALBP1	ralA binding protein 1	57615	0.1
chr12_104194005_104194257	0.75	RP11-650K20.2		19257	0.13
chr3_11610290_11610777	0.75	VGLL4	vestigial like 4 (Drosophila)	135	0.97
chr5_131560990_131561267	0.75	P4HA2	prolyl 4-hydroxylase, alpha polypeptide II	1807	0.32
chr2_241519242_241519542	0.75	RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1	4473	0.13
chr7_101579659_101580126	0.75	CTB-181H17.1		23504	0.22
chr19_41108244_41108427	0.75	LTBP4	latent transforming growth factor beta binding protein 4	1058	0.42
chr2_60757710_60758018	0.73	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	22676	0.2
chr20_50721484_50721986	0.73	ZFP64	ZFP64 zinc finger protein	273	0.95
chr12_10874089_10875353	0.73	YBX3	Y box binding protein 3	1185	0.46
chr11_69925187_69925338	0.73	ANO1	anoctamin 1, calcium activated chloride channel	583	0.69
chr15_44486029_44486998	0.70	FRMD5	FERM domain containing 5	131	0.98
chr9_130860266_130860759	0.70	SLC25A25	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	71	0.93
chr17_80482487_80482690	0.68	FOXK2	forkhead box K2	4997	0.12
chr12_113860437_113860657	0.68	SDSL	serine dehydratase-like	289	0.88
chr5_45163259_45163410	0.68	MRPS30	mitochondrial ribosomal protein S30	354307	0.01
chr1_203449915_203450277	0.67	PRELP	proline/arginine-rich end leucine-rich repeat protein	5140	0.23
chr7_137680969_137681574	0.66	CREB3L2	cAMP responsive element binding protein 3-like 2	5522	0.22
chr16_88837427_88837668	0.65	PIEZO1	piezo-type mechanosensitive ion channel component 1	14072	0.08
chr3_55520023_55520469	0.65	WNT5A	wingless-type MMTV integration site family, member 5A	1085	0.48
chr4_25031967_25032301	0.65	LGI2	leucine-rich repeat LGI family, member 2	153	0.97
chr1_33207592_33208218	0.64	KIAA1522	KIAA1522	419	0.8
chr1_2144612_2144924	0.64	AL590822.1	Uncharacterized protein	852	0.47
chr1_220101375_220102142	0.64	SLC30A10	solute carrier family 30, member 10	186	0.95
chr13_99714734_99715210	0.63	DOCK9	dedicator of cytokinesis 9	23688	0.17
chr1_59043462_59043613	0.63	TACSTD2	tumor-associated calcium signal transducer 2	371	0.88
chr1_205450827_205450978	0.62	CDK18	cyclin-dependent kinase 18	22821	0.14
chr14_58797643_58798017	0.62	ARID4A	AT rich interactive domain 4A (RBP1-like)	175	0.93
chr5_158521759_158522243	0.62	EBF1	early B-cell factor 1	4700	0.29
chr13_74784971_74785134	0.62	KLF12	Kruppel-like factor 12	76658	0.11
chr8_145022099_145022649	0.62	PLEC	plectin	1659	0.22
chrX_139846886_139847110	0.62	CDR1	cerebellar degeneration-related protein 1, 34kDa	19725	0.22
chr4_8317573_8317791	0.61	HTRA3	HtrA serine peptidase 3	46178	0.14
chr20_59829000_59829235	0.61	CDH4	cadherin 4, type 1, R-cadherin (retinal)	1635	0.56
chr8_141728080_141728633	0.61	PTK2	protein tyrosine kinase 2	98	0.98
chr14_55119300_55119828	0.60	SAMD4A	sterile alpha motif domain containing 4A	84927	0.09
chr7_42275396_42275690	0.60	GLI3	GLI family zinc finger 3	1069	0.7
chr16_72882732_72883241	0.60	ENSG00000251868	.	27095	0.17
chr2_228683015_228683311	0.60	CCL20	chemokine (C-C motif) ligand 20	4593	0.24
chr7_38670068_38671048	0.59	AMPH	amphiphysin	462	0.87
chr3_126006504_126006736	0.59	KLF15	Kruppel-like factor 15	69665	0.08
chr15_65176516_65176787	0.59	ENSG00000264929	.	15787	0.13
chr17_79012089_79012389	0.59	BAIAP2	BAI1-associated protein 2	2436	0.2
chr4_154064335_154064653	0.59	TRIM2	tripartite motif containing 2	9151	0.28
chr2_36660395_36660628	0.58	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	76897	0.1
chr5_98396547_98396924	0.58	ENSG00000200351	.	124284	0.06
chr11_64918203_64918661	0.58	ENSG00000222477	.	3377	0.09
chr11_57089258_57089534	0.58	TNKS1BP1	tankyrase 1 binding protein 1, 182kDa	275	0.83
chr11_95888990_95889540	0.57	ENSG00000266192	.	185337	0.03
chr16_74775111_74775280	0.57	FA2H	fatty acid 2-hydroxylase	28	0.98
chr9_124262101_124262557	0.57	ENSG00000240299	.	5532	0.22
chr14_94602985_94603148	0.57	IFI27L2	interferon, alpha-inducible protein 27-like 2	6476	0.16
chr5_176830840_176831699	0.57	GRK6	G protein-coupled receptor kinase 6	138	0.91
chr15_70818827_70819034	0.57	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	175690	0.03
chr19_40871912_40872253	0.56	PLD3	phospholipase D family, member 3	181	0.9
chr11_126010955_126011106	0.56	RP11-50B3.4		67892	0.07
chr19_4866504_4867667	0.55	PLIN3	perilipin 3	39	0.96
chrX_128789131_128789414	0.55	APLN	apelin	339	0.92
chr13_24624586_24624810	0.54	SPATA13	spermatogenesis associated 13	70754	0.1
chr19_34972059_34972243	0.54	WTIP	Wilms tumor 1 interacting protein	277	0.89
chr4_74809740_74810515	0.54	PF4	platelet factor 4	37714	0.11
chr17_20491916_20492779	0.54	CDRT15L2	CMT1A duplicated region transcript 15-like 2	9310	0.21
chr1_159915484_159915973	0.54	IGSF9	immunoglobulin superfamily, member 9	342	0.79
chr2_185463143_185463634	0.54	ZNF804A	zinc finger protein 804A	295	0.95
chr21_28338343_28338505	0.53	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	408	0.88
chr8_80872484_80872635	0.53	RP11-26J3.3		2943	0.33
chr7_47610970_47611742	0.53	TNS3	tensin 3	9873	0.29
chr8_89842231_89842382	0.53	RP11-586K2.1		129786	0.06
chr22_46402821_46403014	0.52	WNT7B	wingless-type MMTV integration site family, member 7B	29908	0.1
chr13_97960259_97960523	0.52	MBNL2	muscleblind-like splicing regulator 2	31933	0.21
chr3_56817720_56817916	0.52	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	8133	0.29
chr8_19266488_19266919	0.52	SH2D4A	SH2 domain containing 4A	89602	0.1
chr9_130284212_130284363	0.52	FAM129B	family with sequence similarity 129, member B	47080	0.09
chr5_66564565_66564999	0.51	CD180	CD180 molecule	72155	0.13
chr22_25372381_25372554	0.51	KIAA1671	KIAA1671	23770	0.18
chr10_33620140_33620362	0.51	NRP1	neuropilin 1	3059	0.34
chr17_25707386_25707582	0.51	TBC1D3P5	TBC1 domain family, member 3 pseudogene 5	39080	0.16
chr11_1897889_1898478	0.50	LSP1	lymphocyte-specific protein 1	476	0.66
chr4_170235942_170236479	0.50	SH3RF1	SH3 domain containing ring finger 1	43954	0.19
chr20_50312898_50313325	0.50	ATP9A	ATPase, class II, type 9A	71756	0.11
chr17_12887644_12888019	0.50	ARHGAP44	Rho GTPase activating protein 44	4406	0.18
chr11_86262739_86262907	0.50	ME3	malic enzyme 3, NADP(+)-dependent, mitochondrial	8039	0.29
chr13_50194281_50194827	0.49	ARL11	ADP-ribosylation factor-like 11	7881	0.21
chr8_42063953_42065062	0.49	PLAT	plasminogen activator, tissue	576	0.71
chr21_33784461_33785454	0.49	EVA1C	eva-1 homolog C (C. elegans)	36	0.97
chr3_146613212_146613363	0.49	ENSG00000251800	.	58578	0.15
chr14_69419495_69419882	0.49	ACTN1	actinin, alpha 1	5423	0.25
chr7_115993814_115993965	0.48	ENSG00000216076	.	7891	0.21
chr17_15689649_15690074	0.48	ENSG00000251829	.	4206	0.19
chr17_37036468_37036913	0.48	LASP1	LIM and SH3 protein 1	6547	0.1
chr2_218843405_218844030	0.47	TNS1	tensin 1	60	0.79
chr4_159969552_159969736	0.47	C4orf45	chromosome 4 open reading frame 45	13311	0.17
chr16_4000635_4001034	0.47	RP11-462G12.1		389	0.84
chr11_66363136_66363287	0.47	CCS	copper chaperone for superoxide dismutase	2499	0.13
chr16_74778068_74778306	0.47	ENSG00000263661	.	2922	0.23
chr12_13346530_13346681	0.46	EMP1	epithelial membrane protein 1	3045	0.33
chr17_38228617_38228812	0.46	THRA	thyroid hormone receptor, alpha	370	0.79
chr8_69242814_69243988	0.46	C8orf34	chromosome 8 open reading frame 34	56	0.82
chr10_126337337_126337630	0.46	FAM53B-AS1	FAM53B antisense RNA 1	54711	0.13
chr12_53624282_53624433	0.45	RARG	retinoic acid receptor, gamma	1601	0.24
chr9_130639317_130639975	0.45	AK1	adenylate kinase 1	376	0.71
chr2_230135388_230135942	0.45	PID1	phosphotyrosine interaction domain containing 1	316	0.93
chr7_92324656_92325109	0.45	ENSG00000206763	.	6246	0.27
chr9_4933355_4933539	0.45	ENSG00000238362	.	34650	0.14
chr4_40665217_40665497	0.45	RBM47	RNA binding motif protein 47	32465	0.19
chr22_46482810_46483184	0.45	FLJ27365	hsa-mir-4763	1114	0.31
chr16_2085937_2086157	0.45	SLC9A3R2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2	2775	0.08
chr13_110521954_110522217	0.44	ENSG00000201161	.	45358	0.18
chr17_45982661_45983102	0.44	SP2	Sp2 transcription factor	9365	0.1
chr1_223919032_223919392	0.44	CAPN2	calpain 2, (m/II) large subunit	19178	0.2
chr15_100583304_100583570	0.44	ENSG00000252957	.	30958	0.16
chr1_156659849_156660107	0.44	NES	nestin	12789	0.08
chr9_35908111_35908318	0.44	HRCT1	histidine rich carboxyl terminus 1	2025	0.23
chr4_26374521_26374672	0.44	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	10444	0.3
chr12_13351879_13352395	0.43	EMP1	epithelial membrane protein 1	2417	0.37
chr10_11203169_11203338	0.43	CELF2	CUGBP, Elav-like family member 2	3740	0.26
chr5_176919974_176920125	0.43	RP11-1334A24.6		1947	0.17
chr2_33361191_33361342	0.43	LTBP1	latent transforming growth factor beta binding protein 1	1542	0.54
chr2_110872063_110872214	0.42	MALL	mal, T-cell differentiation protein-like	1461	0.36
chr9_132514262_132514453	0.42	PTGES	prostaglandin E synthase	969	0.51
chr3_99356620_99357126	0.42	COL8A1	collagen, type VIII, alpha 1	446	0.89
chr2_241265147_241265298	0.42	ENSG00000221412	.	63945	0.11
chr3_174158021_174158288	0.42	NAALADL2	N-acetylated alpha-linked acidic dipeptidase-like 2	623	0.85
chr6_158080653_158080804	0.42	ZDHHC14	zinc finger, DHHC-type containing 14	66687	0.12
chr4_111507244_111507551	0.42	PITX2	paired-like homeodomain 2	36810	0.19
chr12_6644018_6645022	0.42	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	52	0.92
chr11_46708891_46709042	0.42	ARHGAP1	Rho GTPase activating protein 1	8683	0.13
chr9_66486862_66487013	0.42	ENSG00000202474	.	28675	0.27
chr10_79686888_79687096	0.42	DLG5-AS1	DLG5 antisense RNA 1	138	0.87
chr5_32193714_32193865	0.41	GOLPH3	golgi phosphoprotein 3 (coat-protein)	19333	0.18
chr3_10057070_10057667	0.41	EMC3	ER membrane protein complex subunit 3	4568	0.11
chr11_59523287_59523695	0.41	STX3	syntaxin 3	566	0.57
chr12_32050718_32050938	0.41	ENSG00000252584	.	17813	0.2
chr16_10688359_10688510	0.41	EMP2	epithelial membrane protein 2	13879	0.17
chr10_86068772_86068923	0.41	CCSER2	coiled-coil serine-rich protein 2	19495	0.2
chr15_41055526_41056933	0.41	GCHFR	GTP cyclohydrolase I feedback regulator	11	0.96
chr5_106878314_106878602	0.40	EFNA5	ephrin-A5	127870	0.06
chr1_56943511_56943702	0.40	ENSG00000223307	.	100516	0.08
chr2_159825200_159826543	0.40	TANC1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	688	0.73
chr19_16936008_16936179	0.40	SIN3B	SIN3 transcription regulator family member B	4118	0.16
chr1_212420607_212420921	0.40	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	38115	0.14
chr7_143078673_143079796	0.40	ZYX	zyxin	234	0.85
chr17_1014745_1015083	0.40	ABR	active BCR-related	2574	0.31
chr12_106531293_106531501	0.40	NUAK1	NUAK family, SNF1-like kinase, 1	2414	0.35
chr14_51338929_51339207	0.40	ABHD12B	abhydrolase domain containing 12B	190	0.93
chr8_8749576_8750657	0.40	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	1039	0.53
chr2_161151049_161151328	0.39	ITGB6	integrin, beta 6	94373	0.08
chr4_175344307_175344635	0.39	ENSG00000265846	.	475	0.88
chr8_120428169_120429285	0.39	NOV	nephroblastoma overexpressed	181	0.96
chr2_167230570_167230946	0.39	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	1739	0.43
chr19_2578858_2579047	0.39	CTC-265F19.2		32908	0.12
chr1_17519453_17519604	0.39	PADI1	peptidyl arginine deiminase, type I	12093	0.17
chr7_149193458_149193685	0.39	ZNF746	zinc finger protein 746	1253	0.51
chr7_2439740_2440019	0.39	CHST12	carbohydrate (chondroitin 4) sulfotransferase 12	3344	0.25
chr2_237086905_237087412	0.39	GBX2	gastrulation brain homeobox 2	10146	0.15
chr7_55087156_55087307	0.38	EGFR	epidermal growth factor receptor	420	0.91
chr7_130013324_130013755	0.38	CPA1	carboxypeptidase A1 (pancreatic)	6641	0.14
chr14_102094993_102095193	0.38	DIO3	deiodinase, iodothyronine, type III	67405	0.09
chr1_99729766_99730318	0.38	LPPR4	Lipid phosphate phosphatase-related protein type 4	194	0.97
chr5_146796712_146796863	0.38	CTB-108O6.2		15464	0.22
chrX_53309975_53310241	0.38	IQSEC2	IQ motif and Sec7 domain 2	688	0.69
chr7_28527889_28528184	0.38	CREB5	cAMP responsive element binding protein 5	2712	0.43
chr18_9647997_9648175	0.38	ENSG00000212572	.	30016	0.14
chr3_13060724_13060906	0.38	IQSEC1	IQ motif and Sec7 domain 1	32279	0.22
chr2_14775112_14775752	0.38	AC011897.1	Uncharacterized protein	217	0.95
chr17_25886913_25887375	0.37	KSR1	kinase suppressor of ras 1	22803	0.19
chr9_32741891_32742042	0.37	ENSG00000221696	.	22328	0.18
chr9_21964953_21966022	0.37	C9orf53	chromosome 9 open reading frame 53	1650	0.31
chr8_77316107_77316384	0.37	ENSG00000222231	.	138278	0.05
chr4_41259507_41259760	0.37	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	671	0.51
chr2_171822769_171822920	0.37	GORASP2	golgi reassembly stacking protein 2, 55kDa	37013	0.16
chr2_11508334_11508566	0.37	ROCK2	Rho-associated, coiled-coil containing protein kinase 2	23739	0.2
chr22_46330885_46331075	0.36	WNT7B	wingless-type MMTV integration site family, member 7B	37615	0.13
chr1_956379_957022	0.36	AGRN	agrin	1197	0.27
chr2_61407466_61407663	0.36	AHSA2	AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)	2900	0.22
chr17_78044749_78045392	0.36	CCDC40	coiled-coil domain containing 40	12346	0.15
chr3_196133770_196133921	0.36	ENSG00000243339	.	7063	0.11
chr20_30429794_30429945	0.36	FOXS1	forkhead box S1	3551	0.16
chr3_45052751_45053653	0.36	CLEC3B	C-type lectin domain family 3, member B	14473	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.2	1.1	GO:0061525	hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.1	0.4	GO:0018119	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.1	0.4	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.1	0.4	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.1	0.8	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.1	0.3	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1	0.5	GO:0036465	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.1	0.4	GO:0070141	response to UV-A(GO:0070141)
0.1	0.2	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1	0.3	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1	0.4	GO:0001946	lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.1	0.2	GO:2001280	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1	0.3	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.1	0.3	GO:0060214	endocardium formation(GO:0060214)
0.1	0.2	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.2	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.1	0.7	GO:0099518	vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518)
0.1	0.6	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.7	GO:0060438	trachea development(GO:0060438)
0.1	0.2	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.1	0.3	GO:0071680	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.1	0.2	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1	0.2	GO:0030091	protein repair(GO:0030091)
0.1	0.2	GO:0007412	axon target recognition(GO:0007412)
0.1	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.4	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.1	0.4	GO:0046655	folic acid metabolic process(GO:0046655)
0.1	0.2	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1	0.3	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.1	0.2	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0071688	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.2	GO:1901538	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.2	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.3	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.2	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.2	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.2	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.2	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.4	GO:0001516	prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0008614	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:1903521	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.4	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.1	GO:0021571	rhombomere 5 development(GO:0021571)
0.0	0.0	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:1902170	cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.0	0.2	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.2	GO:0031268	pseudopodium organization(GO:0031268)
0.0	0.1	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.7	GO:0048010	vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0	0.6	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.3	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.4	GO:0035195	gene silencing by miRNA(GO:0035195)
0.0	0.1	GO:0021877	forebrain neuron fate commitment(GO:0021877)
0.0	0.0	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0043587	tongue morphogenesis(GO:0043587)
0.0	0.6	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.1	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.4	GO:0042730	fibrinolysis(GO:0042730)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.0	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0	0.1	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.1	GO:0030432	peristalsis(GO:0030432)
0.0	0.1	GO:0021546	rhombomere development(GO:0021546)
0.0	0.0	GO:0045945	positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0	0.3	GO:0007004	telomere maintenance via telomerase(GO:0007004)
0.0	0.1	GO:0045836	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.1	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.0	GO:1901881	positive regulation of protein depolymerization(GO:1901881)
0.0	0.0	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.2	GO:0030252	growth hormone secretion(GO:0030252)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0046084	adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.1	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0034653	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.2	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0048617	foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617)
0.0	0.1	GO:0000959	mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.0	0.1	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.3	GO:0007530	sex determination(GO:0007530)
0.0	0.0	GO:0032328	alanine transport(GO:0032328)
0.0	0.1	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.0	0.0	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.0	GO:0010613	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.0	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.2	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.1	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.3	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0006188	IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0	0.5	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.0	GO:0060592	mammary gland formation(GO:0060592)
0.0	0.1	GO:0098876	Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0	0.1	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.0	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.1	GO:0060009	Sertoli cell differentiation(GO:0060008) Sertoli cell development(GO:0060009)
0.0	0.0	GO:0008354	germ cell migration(GO:0008354)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0072698	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.2	GO:0007176	regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0	0.2	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.1	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	0.7	GO:0016358	dendrite development(GO:0016358)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.2	GO:0009309	amine biosynthetic process(GO:0009309)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0097094	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.0	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.3	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.0	0.0	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.1	GO:0048286	lung alveolus development(GO:0048286)
0.0	0.3	GO:0006493	protein O-linked glycosylation(GO:0006493)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.0	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.1	GO:0098743	cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.0	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.0	GO:0009136	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.0	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.1	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.0	GO:0051974	negative regulation of telomerase activity(GO:0051974)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.0	GO:0030573	bile acid catabolic process(GO:0030573)
0.0	0.0	GO:0046005	positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.0	0.0	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.2	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.0	0.0	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.0	GO:0015824	proline transport(GO:0015824)
0.0	0.0	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0034643	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0031933	telomeric heterochromatin(GO:0031933)
0.1	0.3	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.8	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.1	0.5	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1	0.4	GO:0001950	obsolete plasma membrane enriched fraction(GO:0001950)
0.1	0.3	GO:0002080	acrosomal membrane(GO:0002080)
0.1	0.2	GO:0043083	synaptic cleft(GO:0043083)
0.1	0.4	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.4	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.3	GO:0005915	zonula adherens(GO:0005915)
0.0	0.2	GO:0042599	lamellar body(GO:0042599)
0.0	0.2	GO:0010369	chromocenter(GO:0010369)
0.0	0.2	GO:0031332	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	1.0	GO:0030666	endocytic vesicle membrane(GO:0030666)
0.0	0.2	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.2	GO:0043256	laminin complex(GO:0043256)
0.0	0.0	GO:0060199	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0	0.2	GO:0008091	spectrin(GO:0008091)
0.0	0.4	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.7	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	1.6	GO:0005925	focal adhesion(GO:0005925)
0.0	0.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.6	GO:0043679	axon terminus(GO:0043679)
0.0	0.1	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.3	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.3	GO:0005581	collagen trimer(GO:0005581)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	3.8	GO:0031012	extracellular matrix(GO:0031012)
0.0	0.2	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.1	GO:0031083	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.0	0.0	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.0	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.2	1.3	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.2	0.5	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.2	0.6	GO:0008518	reduced folate carrier activity(GO:0008518)
0.2	0.5	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.1	0.4	GO:0042577	lipid phosphatase activity(GO:0042577)
0.1	0.4	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	0.4	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.5	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1	0.3	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.3	GO:0008517	folic acid transporter activity(GO:0008517)
0.1	0.3	GO:0032190	acrosin binding(GO:0032190)
0.1	0.3	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	0.6	GO:0030506	ankyrin binding(GO:0030506)
0.1	0.2	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1	0.2	GO:0035197	siRNA binding(GO:0035197)
0.1	0.2	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1	0.2	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1	0.5	GO:0017166	vinculin binding(GO:0017166)
0.1	0.2	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.1	0.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.4	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.1	0.2	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1	0.2	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.2	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.5	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.8	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.4	GO:0003840	gamma-glutamyltransferase activity(GO:0003840)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.2	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.2	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.2	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.2	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.2	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.2	GO:0009374	biotin binding(GO:0009374)
0.0	0.2	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.6	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.3	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.3	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.2	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.4	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.1	GO:0019238	cyclohydrolase activity(GO:0019238)
0.0	0.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.2	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.2	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.0	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.2	GO:0015250	water channel activity(GO:0015250)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.4	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.0	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	1.6	GO:0008201	heparin binding(GO:0008201)
0.0	0.1	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.1	GO:0001077	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.1	GO:0042605	peptide antigen binding(GO:0042605)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.2	GO:0005109	frizzled binding(GO:0005109)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0043139	5'-3' DNA helicase activity(GO:0043139)
0.0	0.0	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.2	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.5	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.0	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.0	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.0	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.0	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.3	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.0	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.0	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.0	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.0	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0047617	acyl-CoA hydrolase activity(GO:0047617)
0.0	0.1	GO:0005355	glucose transmembrane transporter activity(GO:0005355)
0.0	0.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0005123	death receptor binding(GO:0005123)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.7	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.7	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.2	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	1.2	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	0.1	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.7	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	1.0	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.7	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	0.2	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	3.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	0.4	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.4	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.3	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	0.1	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.1	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	0.1	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	2.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.1	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	0.8	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	0.1	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.6	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.1	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.9	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.3	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.4	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	1.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.9	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.1	REACTOME LATE PHASE OF HIV LIFE CYCLE	Genes involved in Late Phase of HIV Life Cycle
0.0	0.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.0	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	0.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.3	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.3	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.3	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.1	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.1	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.1	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.1	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions