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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for TLX1_NFIC

Z-value: 1.68

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Transcription factors associated with TLX1_NFIC

Gene Symbol Gene ID Gene Info
TLX1
ENSG00000107807.8 T cell leukemia homeobox 1
NFIC
ENSG00000141905.13 nuclear factor I C

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_3346811_3347036NFIC126380.1747570.853.4e-03Click!
chr19_3358174_3358371NFIC12890.448410-0.817.5e-03Click!
chr19_3363597_3363748NFIC28750.2549940.781.3e-02Click!
chr19_3397384_3397535NFIC308750.1330970.771.6e-02Click!
chr19_3368308_3368459NFIC17990.3455340.703.6e-02Click!
chr10_102894531_102894816TLX136120.1450470.511.6e-01Click!
chr10_102894012_102894163TLX130260.1568120.393.1e-01Click!
chr10_102895075_102895226TLX140890.138354-0.363.4e-01Click!
chr10_102894867_102895065TLX139050.1407200.206.0e-01Click!
chr10_102891889_102892040TLX19030.3600240.127.7e-01Click!

Activity of the TLX1_NFIC motif across conditions

Conditions sorted by the z-value of the TLX1_NFIC motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr17_16389894_16390114 1.54 FAM211A
 family with sequence similarity 211, member A
 5328
 0.18
chr4_158143046_158143598 1.33 GRIA2
 glutamate receptor, ionotropic, AMPA 2
 504
 0.84
chr16_4366907_4367444 1.27 GLIS2
 GLIS family zinc finger 2
 2413
 0.21
chr9_140506939_140507169 1.09 C9orf37
 chromosome 9 open reading frame 37
 6211
 0.12
chr14_75421223_75421487 1.03 PGF
 placental growth factor
 590
 0.68
chr20_45989388_45989864 1.02 ZMYND8
 zinc finger, MYND-type containing 8
 4059
 0.17
chr5_115697275_115697566 0.99 CTB-118N6.3
85823
 0.09
chr8_55294582_55295235 0.99 ENSG00000244107
 .
 38120
 0.17
chr8_65488422_65488732 0.99 RP11-21C4.1
1243
 0.52
chr1_212810031_212810274 0.98 RP11-338C15.5
10039
 0.14
chr9_109459969_109460612 0.97 ENSG00000200131
 .
 18032
 0.28
chr19_1154555_1155129 0.97 SBNO2
 strawberry notch homolog 2 (Drosophila)
 293
 0.85
chr9_25678314_25678778 0.90 TUSC1
 tumor suppressor candidate 1
 310
 0.95
chr10_17390339_17390851 0.87 ST8SIA6
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
 21487
 0.18
chr5_54734053_54734276 0.83 SKIV2L2
 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
 22280
 0.2
chr11_63530349_63531105 0.81 ENSG00000264519
 .
 34816
 0.12
chr7_95401616_95402462 0.80 DYNC1I1
 dynein, cytoplasmic 1, intermediate chain 1
 123
 0.98
chr19_17953136_17953665 0.80 JAK3
 Janus kinase 3
 1856
 0.22
chr1_113243148_113243677 0.79 RHOC
 ras homolog family member C
 4131
 0.12
chr11_106295016_106295231 0.79 RP11-680E19.1
160081
 0.04
chr2_175743189_175743666 0.78 CHN1
 chimerin 1
 30948
 0.19
chr18_9417287_9417498 0.76 RALBP1
 ralA binding protein 1
 57615
 0.1
chr12_104194005_104194257 0.75 RP11-650K20.2
19257
 0.13
chr3_11610290_11610777 0.75 VGLL4
 vestigial like 4 (Drosophila)
 135
 0.97
chr5_131560990_131561267 0.75 P4HA2
 prolyl 4-hydroxylase, alpha polypeptide II
 1807
 0.32
chr2_241519242_241519542 0.75 RNPEPL1
 arginyl aminopeptidase (aminopeptidase B)-like 1
 4473
 0.13
chr7_101579659_101580126 0.75 CTB-181H17.1
23504
 0.22
chr19_41108244_41108427 0.75 LTBP4
 latent transforming growth factor beta binding protein 4
 1058
 0.42
chr2_60757710_60758018 0.73 BCL11A
 B-cell CLL/lymphoma 11A (zinc finger protein)
 22676
 0.2
chr20_50721484_50721986 0.73 ZFP64
 ZFP64 zinc finger protein
 273
 0.95
chr12_10874089_10875353 0.73 YBX3
 Y box binding protein 3
 1185
 0.46
chr11_69925187_69925338 0.73 ANO1
 anoctamin 1, calcium activated chloride channel
 583
 0.69
chr15_44486029_44486998 0.70 FRMD5
 FERM domain containing 5
 131
 0.98
chr9_130860266_130860759 0.70 SLC25A25
 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
 71
 0.93
chr17_80482487_80482690 0.68 FOXK2
 forkhead box K2
 4997
 0.12
chr12_113860437_113860657 0.68 SDSL
 serine dehydratase-like
 289
 0.88
chr5_45163259_45163410 0.68 MRPS30
 mitochondrial ribosomal protein S30
 354307
 0.01
chr1_203449915_203450277 0.67 PRELP
 proline/arginine-rich end leucine-rich repeat protein
 5140
 0.23
chr7_137680969_137681574 0.66 CREB3L2
 cAMP responsive element binding protein 3-like 2
 5522
 0.22
chr16_88837427_88837668 0.65 PIEZO1
 piezo-type mechanosensitive ion channel component 1
 14072
 0.08
chr3_55520023_55520469 0.65 WNT5A
 wingless-type MMTV integration site family, member 5A
 1085
 0.48
chr4_25031967_25032301 0.65 LGI2
 leucine-rich repeat LGI family, member 2
 153
 0.97
chr1_33207592_33208218 0.64 KIAA1522
 KIAA1522
 419
 0.8
chr1_2144612_2144924 0.64 AL590822.1
 Uncharacterized protein
 852
 0.47
chr1_220101375_220102142 0.64 SLC30A10
 solute carrier family 30, member 10
 186
 0.95
chr13_99714734_99715210 0.63 DOCK9
 dedicator of cytokinesis 9
 23688
 0.17
chr1_59043462_59043613 0.63 TACSTD2
 tumor-associated calcium signal transducer 2
 371
 0.88
chr1_205450827_205450978 0.62 CDK18
 cyclin-dependent kinase 18
 22821
 0.14
chr14_58797643_58798017 0.62 ARID4A
 AT rich interactive domain 4A (RBP1-like)
 175
 0.93
chr5_158521759_158522243 0.62 EBF1
 early B-cell factor 1
 4700
 0.29
chr13_74784971_74785134 0.62 KLF12
 Kruppel-like factor 12
 76658
 0.11
chr8_145022099_145022649 0.62 PLEC
 plectin
 1659
 0.22
chrX_139846886_139847110 0.62 CDR1
 cerebellar degeneration-related protein 1, 34kDa
 19725
 0.22
chr4_8317573_8317791 0.61 HTRA3
 HtrA serine peptidase 3
 46178
 0.14
chr20_59829000_59829235 0.61 CDH4
 cadherin 4, type 1, R-cadherin (retinal)
 1635
 0.56
chr8_141728080_141728633 0.61 PTK2
 protein tyrosine kinase 2
 98
 0.98
chr14_55119300_55119828 0.60 SAMD4A
 sterile alpha motif domain containing 4A
 84927
 0.09
chr7_42275396_42275690 0.60 GLI3
 GLI family zinc finger 3
 1069
 0.7
chr16_72882732_72883241 0.60 ENSG00000251868
 .
 27095
 0.17
chr2_228683015_228683311 0.60 CCL20
 chemokine (C-C motif) ligand 20
 4593
 0.24
chr7_38670068_38671048 0.59 AMPH
 amphiphysin
 462
 0.87
chr3_126006504_126006736 0.59 KLF15
 Kruppel-like factor 15
 69665
 0.08
chr15_65176516_65176787 0.59 ENSG00000264929
 .
 15787
 0.13
chr17_79012089_79012389 0.59 BAIAP2
 BAI1-associated protein 2
 2436
 0.2
chr4_154064335_154064653 0.59 TRIM2
 tripartite motif containing 2
 9151
 0.28
chr2_36660395_36660628 0.58 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 76897
 0.1
chr5_98396547_98396924 0.58 ENSG00000200351
 .
 124284
 0.06
chr11_64918203_64918661 0.58 ENSG00000222477
 .
 3377
 0.09
chr11_57089258_57089534 0.58 TNKS1BP1
 tankyrase 1 binding protein 1, 182kDa
 275
 0.83
chr11_95888990_95889540 0.57 ENSG00000266192
 .
 185337
 0.03
chr16_74775111_74775280 0.57 FA2H
 fatty acid 2-hydroxylase
 28
 0.98
chr9_124262101_124262557 0.57 ENSG00000240299
 .
 5532
 0.22
chr14_94602985_94603148 0.57 IFI27L2
 interferon, alpha-inducible protein 27-like 2
 6476
 0.16
chr5_176830840_176831699 0.57 GRK6
 G protein-coupled receptor kinase 6
 138
 0.91
chr15_70818827_70819034 0.57 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 175690
 0.03
chr19_40871912_40872253 0.56 PLD3
 phospholipase D family, member 3
 181
 0.9
chr11_126010955_126011106 0.56 RP11-50B3.4
67892
 0.07
chr19_4866504_4867667 0.55 PLIN3
 perilipin 3
 39
 0.96
chrX_128789131_128789414 0.55 APLN
 apelin
 339
 0.92
chr13_24624586_24624810 0.54 SPATA13
 spermatogenesis associated 13
 70754
 0.1
chr19_34972059_34972243 0.54 WTIP
 Wilms tumor 1 interacting protein
 277
 0.89
chr4_74809740_74810515 0.54 PF4
 platelet factor 4
 37714
 0.11
chr17_20491916_20492779 0.54 CDRT15L2
 CMT1A duplicated region transcript 15-like 2
 9310
 0.21
chr1_159915484_159915973 0.54 IGSF9
 immunoglobulin superfamily, member 9
 342
 0.79
chr2_185463143_185463634 0.54 ZNF804A
 zinc finger protein 804A
 295
 0.95
chr21_28338343_28338505 0.53 ADAMTS5
 ADAM metallopeptidase with thrombospondin type 1 motif, 5
 408
 0.88
chr8_80872484_80872635 0.53 RP11-26J3.3
2943
 0.33
chr7_47610970_47611742 0.53 TNS3
 tensin 3
 9873
 0.29
chr8_89842231_89842382 0.53 RP11-586K2.1
129786
 0.06
chr22_46402821_46403014 0.52 WNT7B
 wingless-type MMTV integration site family, member 7B
 29908
 0.1
chr13_97960259_97960523 0.52 MBNL2
 muscleblind-like splicing regulator 2
 31933
 0.21
chr3_56817720_56817916 0.52 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 8133
 0.29
chr8_19266488_19266919 0.52 SH2D4A
 SH2 domain containing 4A
 89602
 0.1
chr9_130284212_130284363 0.52 FAM129B
 family with sequence similarity 129, member B
 47080
 0.09
chr5_66564565_66564999 0.51 CD180
 CD180 molecule
 72155
 0.13
chr22_25372381_25372554 0.51 KIAA1671
 KIAA1671
 23770
 0.18
chr10_33620140_33620362 0.51 NRP1
 neuropilin 1
 3059
 0.34
chr17_25707386_25707582 0.51 TBC1D3P5
 TBC1 domain family, member 3 pseudogene 5
 39080
 0.16
chr11_1897889_1898478 0.50 LSP1
 lymphocyte-specific protein 1
 476
 0.66
chr4_170235942_170236479 0.50 SH3RF1
 SH3 domain containing ring finger 1
 43954
 0.19
chr20_50312898_50313325 0.50 ATP9A
 ATPase, class II, type 9A
 71756
 0.11
chr17_12887644_12888019 0.50 ARHGAP44
 Rho GTPase activating protein 44
 4406
 0.18
chr11_86262739_86262907 0.50 ME3
 malic enzyme 3, NADP(+)-dependent, mitochondrial
 8039
 0.29
chr13_50194281_50194827 0.49 ARL11
 ADP-ribosylation factor-like 11
 7881
 0.21
chr8_42063953_42065062 0.49 PLAT
 plasminogen activator, tissue
 576
 0.71
chr21_33784461_33785454 0.49 EVA1C
 eva-1 homolog C (C. elegans)
 36
 0.97
chr3_146613212_146613363 0.49 ENSG00000251800
 .
 58578
 0.15
chr14_69419495_69419882 0.49 ACTN1
 actinin, alpha 1
 5423
 0.25
chr7_115993814_115993965 0.48 ENSG00000216076
 .
 7891
 0.21
chr17_15689649_15690074 0.48 ENSG00000251829
 .
 4206
 0.19
chr17_37036468_37036913 0.48 LASP1
 LIM and SH3 protein 1
 6547
 0.1
chr2_218843405_218844030 0.47 TNS1
 tensin 1
 60
 0.79
chr4_159969552_159969736 0.47 C4orf45
 chromosome 4 open reading frame 45
 13311
 0.17
chr16_4000635_4001034 0.47 RP11-462G12.1
389
 0.84
chr11_66363136_66363287 0.47 CCS
 copper chaperone for superoxide dismutase
 2499
 0.13
chr16_74778068_74778306 0.47 ENSG00000263661
 .
 2922
 0.23
chr12_13346530_13346681 0.46 EMP1
 epithelial membrane protein 1
 3045
 0.33
chr17_38228617_38228812 0.46 THRA
 thyroid hormone receptor, alpha
 370
 0.79
chr8_69242814_69243988 0.46 C8orf34
 chromosome 8 open reading frame 34
 56
 0.82
chr10_126337337_126337630 0.46 FAM53B-AS1
 FAM53B antisense RNA 1
 54711
 0.13
chr12_53624282_53624433 0.45 RARG
 retinoic acid receptor, gamma
 1601
 0.24
chr9_130639317_130639975 0.45 AK1
 adenylate kinase 1
 376
 0.71
chr2_230135388_230135942 0.45 PID1
 phosphotyrosine interaction domain containing 1
 316
 0.93
chr7_92324656_92325109 0.45 ENSG00000206763
 .
 6246
 0.27
chr9_4933355_4933539 0.45 ENSG00000238362
 .
 34650
 0.14
chr4_40665217_40665497 0.45 RBM47
 RNA binding motif protein 47
 32465
 0.19
chr22_46482810_46483184 0.45 FLJ27365
 hsa-mir-4763
 1114
 0.31
chr16_2085937_2086157 0.45 SLC9A3R2
 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
 2775
 0.08
chr13_110521954_110522217 0.44 ENSG00000201161
 .
 45358
 0.18
chr17_45982661_45983102 0.44 SP2
 Sp2 transcription factor
 9365
 0.1
chr1_223919032_223919392 0.44 CAPN2
 calpain 2, (m/II) large subunit
 19178
 0.2
chr15_100583304_100583570 0.44 ENSG00000252957
 .
 30958
 0.16
chr1_156659849_156660107 0.44 NES
 nestin
 12789
 0.08
chr9_35908111_35908318 0.44 HRCT1
 histidine rich carboxyl terminus 1
 2025
 0.23
chr4_26374521_26374672 0.44 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 10444
 0.3
chr12_13351879_13352395 0.43 EMP1
 epithelial membrane protein 1
 2417
 0.37
chr10_11203169_11203338 0.43 CELF2
 CUGBP, Elav-like family member 2
 3740
 0.26
chr5_176919974_176920125 0.43 RP11-1334A24.6
1947
 0.17
chr2_33361191_33361342 0.43 LTBP1
 latent transforming growth factor beta binding protein 1
 1542
 0.54
chr2_110872063_110872214 0.42 MALL
 mal, T-cell differentiation protein-like
 1461
 0.36
chr9_132514262_132514453 0.42 PTGES
 prostaglandin E synthase
 969
 0.51
chr3_99356620_99357126 0.42 COL8A1
 collagen, type VIII, alpha 1
 446
 0.89
chr2_241265147_241265298 0.42 ENSG00000221412
 .
 63945
 0.11
chr3_174158021_174158288 0.42 NAALADL2
 N-acetylated alpha-linked acidic dipeptidase-like 2
 623
 0.85
chr6_158080653_158080804 0.42 ZDHHC14
 zinc finger, DHHC-type containing 14
 66687
 0.12
chr4_111507244_111507551 0.42 PITX2
 paired-like homeodomain 2
 36810
 0.19
chr12_6644018_6645022 0.42 GAPDH
 glyceraldehyde-3-phosphate dehydrogenase
 52
 0.92
chr11_46708891_46709042 0.42 ARHGAP1
 Rho GTPase activating protein 1
 8683
 0.13
chr9_66486862_66487013 0.42 ENSG00000202474
 .
 28675
 0.27
chr10_79686888_79687096 0.42 DLG5-AS1
 DLG5 antisense RNA 1
 138
 0.87
chr5_32193714_32193865 0.41 GOLPH3
 golgi phosphoprotein 3 (coat-protein)
 19333
 0.18
chr3_10057070_10057667 0.41 EMC3
 ER membrane protein complex subunit 3
 4568
 0.11
chr11_59523287_59523695 0.41 STX3
 syntaxin 3
 566
 0.57
chr12_32050718_32050938 0.41 ENSG00000252584
 .
 17813
 0.2
chr16_10688359_10688510 0.41 EMP2
 epithelial membrane protein 2
 13879
 0.17
chr10_86068772_86068923 0.41 CCSER2
 coiled-coil serine-rich protein 2
 19495
 0.2
chr15_41055526_41056933 0.41 GCHFR
 GTP cyclohydrolase I feedback regulator
 11
 0.96
chr5_106878314_106878602 0.40 EFNA5
 ephrin-A5
 127870
 0.06
chr1_56943511_56943702 0.40 ENSG00000223307
 .
 100516
 0.08
chr2_159825200_159826543 0.40 TANC1
 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
 688
 0.73
chr19_16936008_16936179 0.40 SIN3B
 SIN3 transcription regulator family member B
 4118
 0.16
chr1_212420607_212420921 0.40 PPP2R5A
 protein phosphatase 2, regulatory subunit B', alpha
 38115
 0.14
chr7_143078673_143079796 0.40 ZYX
 zyxin
 234
 0.85
chr17_1014745_1015083 0.40 ABR
 active BCR-related
 2574
 0.31
chr12_106531293_106531501 0.40 NUAK1
 NUAK family, SNF1-like kinase, 1
 2414
 0.35
chr14_51338929_51339207 0.40 ABHD12B
 abhydrolase domain containing 12B
 190
 0.93
chr8_8749576_8750657 0.40 MFHAS1
 malignant fibrous histiocytoma amplified sequence 1
 1039
 0.53
chr2_161151049_161151328 0.39 ITGB6
 integrin, beta 6
 94373
 0.08
chr4_175344307_175344635 0.39 ENSG00000265846
 .
 475
 0.88
chr8_120428169_120429285 0.39 NOV
 nephroblastoma overexpressed
 181
 0.96
chr2_167230570_167230946 0.39 SCN9A
 sodium channel, voltage-gated, type IX, alpha subunit
 1739
 0.43
chr19_2578858_2579047 0.39 CTC-265F19.2
32908
 0.12
chr1_17519453_17519604 0.39 PADI1
 peptidyl arginine deiminase, type I
 12093
 0.17
chr7_149193458_149193685 0.39 ZNF746
 zinc finger protein 746
 1253
 0.51
chr7_2439740_2440019 0.39 CHST12
 carbohydrate (chondroitin 4) sulfotransferase 12
 3344
 0.25
chr2_237086905_237087412 0.39 GBX2
 gastrulation brain homeobox 2
 10146
 0.15
chr7_55087156_55087307 0.38 EGFR
 epidermal growth factor receptor
 420
 0.91
chr7_130013324_130013755 0.38 CPA1
 carboxypeptidase A1 (pancreatic)
 6641
 0.14
chr14_102094993_102095193 0.38 DIO3
 deiodinase, iodothyronine, type III
 67405
 0.09
chr1_99729766_99730318 0.38 LPPR4
 Lipid phosphate phosphatase-related protein type 4
 194
 0.97
chr5_146796712_146796863 0.38 CTB-108O6.2
15464
 0.22
chrX_53309975_53310241 0.38 IQSEC2
 IQ motif and Sec7 domain 2
 688
 0.69
chr7_28527889_28528184 0.38 CREB5
 cAMP responsive element binding protein 5
 2712
 0.43
chr18_9647997_9648175 0.38 ENSG00000212572
 .
 30016
 0.14
chr3_13060724_13060906 0.38 IQSEC1
 IQ motif and Sec7 domain 1
 32279
 0.22
chr2_14775112_14775752 0.38 AC011897.1
 Uncharacterized protein
 217
 0.95
chr17_25886913_25887375 0.37 KSR1
 kinase suppressor of ras 1
 22803
 0.19
chr9_32741891_32742042 0.37 ENSG00000221696
 .
 22328
 0.18
chr9_21964953_21966022 0.37 C9orf53
 chromosome 9 open reading frame 53
 1650
 0.31
chr8_77316107_77316384 0.37 ENSG00000222231
 .
 138278
 0.05
chr4_41259507_41259760 0.37 UCHL1
 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
 671
 0.51
chr2_171822769_171822920 0.37 GORASP2
 golgi reassembly stacking protein 2, 55kDa
 37013
 0.16
chr2_11508334_11508566 0.37 ROCK2
 Rho-associated, coiled-coil containing protein kinase 2
 23739
 0.2
chr22_46330885_46331075 0.36 WNT7B
 wingless-type MMTV integration site family, member 7B
 37615
 0.13
chr1_956379_957022 0.36 AGRN
 agrin
 1197
 0.27
chr2_61407466_61407663 0.36 AHSA2
 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
 2900
 0.22
chr17_78044749_78045392 0.36 CCDC40
 coiled-coil domain containing 40
 12346
 0.15
chr3_196133770_196133921 0.36 ENSG00000243339
 .
 7063
 0.11
chr20_30429794_30429945 0.36 FOXS1
 forkhead box S1
 3551
 0.16
chr3_45052751_45053653 0.36 CLEC3B
 C-type lectin domain family 3, member B
 14473
 0.15

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.2 1.1 GO:0061525 hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.1 0.4 GO:0018119 protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.1 0.4 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.1 0.4 GO:2000143 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.1 0.8 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.1 0.3 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1 0.5 GO:0036465 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.1 0.4 GO:0070141 response to UV-A(GO:0070141)
0.1 0.2 GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1 0.3 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1 0.4 GO:0001946 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.1 0.2 GO:2001280 regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.3 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.1 0.3 GO:0060214 endocardium formation(GO:0060214)
0.1 0.2 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 0.7 GO:0099518 vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518)
0.1 0.6 GO:0007172 signal complex assembly(GO:0007172)
0.1 0.7 GO:0060438 trachea development(GO:0060438)
0.1 0.2 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.1 0.3 GO:0071680 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.1 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1 0.2 GO:0030091 protein repair(GO:0030091)
0.1 0.2 GO:0007412 axon target recognition(GO:0007412)
0.1 0.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.4 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 0.4 GO:0046655 folic acid metabolic process(GO:0046655)
0.1 0.2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 0.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0071688 skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.2 GO:1901538 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.2 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.3 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.2 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.2 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.4 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.1 GO:1903521 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.4 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.1 GO:0000101 sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0 0.1 GO:0021571 rhombomere 5 development(GO:0021571)
0.0 0.0 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:1902170 cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.0 0.2 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.2 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.1 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.7 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.6 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0032288 myelin assembly(GO:0032288)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.4 GO:0035195 gene silencing by miRNA(GO:0035195)
0.0 0.1 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.0 0.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 0.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.4 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.0 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 0.1 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0044320 cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.1 GO:0030432 peristalsis(GO:0030432)
0.0 0.1 GO:0021546 rhombomere development(GO:0021546)
0.0 0.0 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0 0.3 GO:0007004 telomere maintenance via telomerase(GO:0007004)
0.0 0.1 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0 0.1 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.0 GO:1901881 positive regulation of protein depolymerization(GO:1901881)
0.0 0.0 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.2 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0046084 adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0 0.1 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.1 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0034653 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.2 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0048617 foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617)
0.0 0.1 GO:0000959 mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.0 0.1 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.3 GO:0007530 sex determination(GO:0007530)
0.0 0.0 GO:0032328 alanine transport(GO:0032328)
0.0 0.1 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.0 GO:0010613 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0 0.0 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.2 GO:0046718 viral entry into host cell(GO:0046718)
0.0 0.1 GO:0006896 Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0 0.3 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.0 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.1 GO:0006188 IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0 0.5 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.1 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.0 GO:0060592 mammary gland formation(GO:0060592)
0.0 0.1 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0 0.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.0 GO:0044803 multi-organism membrane organization(GO:0044803)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.0 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.1 GO:0060009 Sertoli cell differentiation(GO:0060008) Sertoli cell development(GO:0060009)
0.0 0.0 GO:0008354 germ cell migration(GO:0008354)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:0045007 depurination(GO:0045007)
0.0 0.0 GO:0072698 protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.2 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0 0.2 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.7 GO:0016358 dendrite development(GO:0016358)
0.0 0.0 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0009309 amine biosynthetic process(GO:0009309)
0.0 0.0 GO:0071436 sodium ion export(GO:0071436)
0.0 0.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0097094 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.0 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.0 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:0007494 midgut development(GO:0007494)
0.0 0.0 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.0 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.0 GO:0010159 specification of organ position(GO:0010159)
0.0 0.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.0 GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.1 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.3 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.1 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.0 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.0 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.1 GO:0098743 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0 0.0 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.0 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.0 GO:0032632 interleukin-3 production(GO:0032632)
0.0 0.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.0 GO:0051974 negative regulation of telomerase activity(GO:0051974)
0.0 0.0 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.0 GO:0030573 bile acid catabolic process(GO:0030573)
0.0 0.0 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.0 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.0 0.0 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.2 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.0 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0 0.0 GO:0015824 proline transport(GO:0015824)
0.0 0.0 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.3 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.5 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1 0.4 GO:0001950 obsolete plasma membrane enriched fraction(GO:0001950)
0.1 0.3 GO:0002080 acrosomal membrane(GO:0002080)
0.1 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.4 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.4 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0042599 lamellar body(GO:0042599)
0.0 0.2 GO:0010369 chromocenter(GO:0010369)
0.0 0.2 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.0 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0043256 laminin complex(GO:0043256)
0.0 0.0 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 1.6 GO:0005925 focal adhesion(GO:0005925)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.6 GO:0043679 axon terminus(GO:0043679)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.3 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 3.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0031083 BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0 0.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.2 1.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 0.5 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 0.6 GO:0008518 reduced folate carrier activity(GO:0008518)
0.2 0.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.4 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 0.3 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.3 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 0.3 GO:0032190 acrosin binding(GO:0032190)
0.1 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.6 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.2 GO:0035197 siRNA binding(GO:0035197)
0.1 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.5 GO:0017166 vinculin binding(GO:0017166)
0.1 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.4 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 0.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 0.2 GO:0031545 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.2 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.4 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.2 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.1 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0009374 biotin binding(GO:0009374)
0.0 0.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.0 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.3 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.4 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.2 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0051636 obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.0 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.4 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.0 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 1.6 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.1 GO:0001077 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.0 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0005109 frizzled binding(GO:0005109)
0.0 0.0 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.0 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.0 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.0 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.0 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.0 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.3 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.0 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.0 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.0 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.0 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.0 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.1 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0005123 death receptor binding(GO:0005123)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.7 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.7 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.1 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.7 ST GA13 PATHWAY G alpha 13 Pathway
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.1 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 3.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.1 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.1 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 0.8 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.1 REACTOME KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.1 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.0 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions